Ishikawa Kei-ichi 石川景一

Researcher Number	90733973
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 准教授 2019 – 2020: 順天堂大学, 医学(系)研究科(研究院), 助教 2016 – 2020: 順天堂大学, 医学部, 非常勤助教 2014 – 2015: 順天堂大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields / Complex Systems Disease Theory / Biological Sciences / Neurology
Keywords	Principal Investigator iPS細胞 / パーキンソン病 / アルファシヌクレイン / αシヌクレイン / 老化 / ドパミン神経 / オートファジー / 交感神経 / 自律神経 / アストロサイト … More / ドーパミン神経細胞 / 細胞老化 / 薬剤スクリーニング / マイトファジー / ドーパミン神経 … More Except Principal Investigator パーキンソン病 / オートファジー / 神経変性疾患 / iPS細胞 / ポリアミン / 神経内科学 / 遠隔効果 / miRNA / ケミカルバイオロジー / 脳・神経 / 内科 / リソソーム / 高速3Dフローイメージャー / 高速イメージャー / 深層学習 / 機械学習 / 神経分化 / 層別化 / 細胞分化誘導 / ヒト人工多能性幹細胞 / ペリサイト / 内皮細胞 / 血液脳関門 / 臓器連関 / 脂肪酸代謝 / 臓器円環 / 肝臓 / 甲状腺 / 骨格筋 / ポリアミン代謝 / カフェイン代謝 / 脂肪酸β酸化 / 代謝産物 / メタボローム解析 / ES細胞 / 代謝 / ミトコンドリア / スペルミジン / スペルミン / ジアセチルスペルミジン / バイオマーカー / 小分子化合物 / 蛋白分解 / 創薬シーズ / マイトファジー / 神経変性 Less

パーキンソン病iPS細胞を用いたαシヌクレインによる自律神経病態の解明Principal Investigator
- Principal Investigator
  
  石川景一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Classification of sporadic Parkinson's disease from patient iPS cell phenotypes
- Principal Investigator
  
  AKAMATSU WADO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
神経変性疾患由来iPS細胞を用いたin vitro血液脳関門モデル構築と病態解析
- Principal Investigator
  
  野中里紗
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
Generation of an aged Parkinson's disease brain model and elucidation of its pathophysiology using iPS cellsPrincipal Investigator
- Principal Investigator
  
  Ishikawa Kei-ichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Research on PD pathogenesis based on polyamine metabolism using multiomics analysis
- Principal Investigator
  
  Saiki Shinji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Juntendo University
Elucidation of the mechanism of Parkinson's disease iPS cell-derived dopaminergic nerurons due to agingPrincipal Investigator
- Principal Investigator
  
  Ishikawa Kei-ichi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Identification of Parkinson disease-specific mitochondrial pathogenesis for disease-modifying therapy
- Principal Investigator
  
  Saiki Shinji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Juntendo University
Identification of Parkinson's disease progression markers based on skeletal muscle-brain axis
- Principal Investigator
  
  Saiki Shinji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Establishment of dopamine neuron specific disease model using iPS cells derived from hereditary Parkinson's diseasesPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA KEI-ICHI
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Development of anti-PD chemicals modulating autophagic activity based on lysosomal function
- Principal Investigator
  
  Shinji Saiki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Analysis of autophagic impairment in neurons derived from familial parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  Ishikawa Kei-ichi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Development of autophagy enhancing chemicals based on Parkinson's disease pathogenesis.
- Principal Investigator
  
  SAIKI Shinji
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Generation of one induced pluripotent stem cell line JUCGRMi004-A from a Charcot-Marie-Tooth disease type 1A (CMT1A) patient with PMP22 duplication2024
- Author(s)
  Liu Xing、Ishikawa Kei-ichi、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Research
  
  Volume: 77 Pages: 103401-103401
- DOI
  10.1016/j.scr.2024.103401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02814
[Journal Article] Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation2024
- Author(s)
  Ishikawa Kei-ichi、Okuzumi Ayami、Yoshino Hiroyo、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Research
  
  Volume: 76 Pages: 103323-103323
- DOI
  10.1016/j.scr.2024.103323
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06934, KAKENHI-PROJECT-21H02814
[Journal Article] Generation of a control iPS cell line (JUCGRMi005-A) with no abnormalities in Parkinson's disease-related genes2024
- Author(s)
  Ishikawa Kei-ichi、Shiga Takahiro、Funayama Manabu、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Research
  
  Volume: 74 Pages: 103271-103271
- DOI
  10.1016/j.scr.2023.103271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06934, KAKENHI-PROJECT-21H02814
[Journal Article] Generation of three clones (JUCGRMi002-A, B, C) of induced pluripotent stem cells from a Parkinson’s disease patient with SNCA duplication2024
- Author(s)
  Ishikawa Kei-ichi、Shiga Takahiro、Yoshino Hiroyo、Nishioka Kenya、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Research
  
  Volume: 74 Pages: 103296-103296
- DOI
  10.1016/j.scr.2023.103296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06934, KAKENHI-PROJECT-21H02814
[Journal Article] Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes2024
- Author(s)
  Ishikawa Kei-ichi、Shiga Takahiro、Funayama Manabu、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Research
  
  Volume: 74 Pages: 103270-103270
- DOI
  10.1016/j.scr.2023.103270
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06934, KAKENHI-PROJECT-21H02814
[Journal Article] Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by <scp>CHCHD2</scp>2023
- Author(s)
  Torii Satoru、Arakawa Satoko、Sato Shigeto、Ishikawa Kei‐ichi、Taniguchi Daisuke、Sakurai Hajime Tajima、Honda Shinya、Hiraoka Yuuichi、Ono Masaya、Akamatsu Wado、Hattori Nobutaka、Shimizu Shigeomi
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 15 Issue: 9
- DOI
  10.15252/emmm.202317451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05748, KAKENHI-PUBLICLY-22H04639, KAKENHI-PROJECT-21H02814
[Journal Article] Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines.2023
- Author(s)
  Yokota M, Yoshino Y, Hosoi M, Hashimoto R, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M.
- Journal Title
  
  Front Cell Dev Biol.
  
  Volume: 11
- DOI
  10.3389/fcell.2023.1171440
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07523, KAKENHI-PROJECT-23K06323, KAKENHI-PROJECT-21H02814
[Journal Article] A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson’s disease2023
- Author(s)
  Nakamura Ryota、Nonaka Risa、Oyama Genko、Jo Takayuki、Kamo Hikaru、Nuermaimaiti Maierdanjiang、Akamatsu Wado、Ishikawa Kei-ichi、Hattori Nobutaka
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 17
- DOI
  10.3389/fnins.2023.1202027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19409, KAKENHI-PROJECT-21H02814
[Journal Article] Generation of three hiPSC clones from a Parkinson's disease patient with a heterozygous variant of VPS35 p.D620N2022
- Author(s)
  Kei-Ichi Ishikawa, Mayu Ishiguro, Yuanzhe Li , Kenya Nishioka, Nobutaka Hattori, Wado Akamatsu
- Journal Title
  
  Stem Cell Research
  
  Volume: 60 Pages: 102739-102739
- DOI
  10.1016/j.scr.2022.102739
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-21K07283, KAKENHI-PROJECT-20K07873
[Journal Article] Autophagy promotes cell survival by maintaining NAD levels2022
- Author(s)
  Kataura Tetsushi、et al、Imoto Masaya、et al & Korolchuk Viktor I.
- Journal Title
  
  Developmental Cell
  
  Volume: 57 Issue: 22 Pages: 2584-2598
- DOI
  10.1016/j.devcel.2022.10.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02072, KAKENHI-PROJECT-20K07873
[Journal Article] Methods to Induce Small-Scale Differentiation of iPS Cells into Dopaminergic Neurons and to Detect Disease Phenotypes2021
- Author(s)
  Yamaguchi Akihiro、Ishikawa Kei-ichi、Akamatsu Wado
- Journal Title
  
  Methods in Molecular Biology.
  
  Volume: - Pages: 1-9
- DOI
  10.1007/7651_2021_376
- ISBN
  9781071625842, 9781071625859
- Data Source
  KAKENHI-PROJECT-20K07873
[Journal Article] Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons2021
- Author(s)
  Yokota Mutsumi、Kakuta Soichiro、Shiga Takahiro、Ishikawa Kei-ichi、Okano Hideyuki、Hattori Nobutaka、Akamatsu Wado、Koike Masato
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Issue: 1 Pages: 58-58
- DOI
  10.1186/s13041-021-00771-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07743, KAKENHI-PROJECT-18K15466, KAKENHI-PROJECT-19K16930, KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-21K07301
[Journal Article] Differentiation of Midbrain from Human iPS Cells2021
- Author(s)
  Ishikawa Kei-Ichi、Nonaka Risa、Akamatsu Wado
- Journal Title
  
  Experimental Models of Parkinson’s Disease. Methods in Molecular Biology
  
  Volume: - Pages: 73-80
- DOI
  10.1007/978-1-0716-1495-2_8
- ISBN
  9781071614945, 9781071614952
- Data Source
  KAKENHI-PROJECT-20K07873
[Journal Article] A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling2020
- Author(s)
  Shiba-Fukushima Kahori、Inoshita Tsuyoshi、Sano Osamu、Iwata Hidehisa、Ishikawa Kei-ichi、Okano Hideyuki、Akamatsu Wado、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 5 Pages: 101048-101048
- DOI
  10.1016/j.isci.2020.101048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-17K09765
[Journal Article] Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease2020
- Author(s)
  Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, et al.
- Journal Title
  
  Brain
  
  Volume: 143 Issue: 4 Pages: 1190-1205
- DOI
  10.1093/brain/awaa064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-19K17019, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K15463, KAKENHI-PROJECT-19K08288, KAKENHI-PROJECT-18K07510, KAKENHI-PROJECT-19K23782
[Journal Article] A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers2020
- Author(s)
  Kataura Tetsushi、Tashiro Etsu、Nishikawa Shota、Shibahara Kensuke、Muraoka Yoshihito、Miura Masahiro、Sakai Shun、Katoh Naohiro、Totsuka Misato、Onodera Masafumi、Shin-Ya Kazuo、Miyamoto Kengo、Sasazawa Yukiko、Hattori Nobutaka、Saiki Shinji、Imoto Masaya
- Journal Title
  
  Autophagy
  
  Volume: Aug 7 Issue: 8 Pages: 1-17
- DOI
  10.1080/15548627.2020.1794590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05732, KAKENHI-PROJECT-18KK0242, KAKENHI-PLANNED-17H06401, KAKENHI-PUBLICLY-20H05340, KAKENHI-PROJECT-18H02099, KAKENHI-PROJECT-16H06276
[Journal Article] BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson’s disease model.2020
- Author(s)
  Kataura, T., Saiki, S., Ishikawa, K., Akamatsu, W., Sasazawa, Y., Hattori, N., Imoto, M.
- Journal Title
  
  J. Neurochemstry
  
  Volume: - Issue: 1 Pages: 81-97
- DOI
  10.1111/jnc.14997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-19J12969, KAKENHI-PROJECT-18K15463, KAKENHI-PROJECT-18K15464, KAKENHI-PROJECT-16H06276, KAKENHI-PUBLICLY-20H05340, KAKENHI-PROJECT-18H02099
[Journal Article] Shared Metabolic Profile of Caffeine in Parkinsonian Disorders2020
- Author(s)
  Takeshige‐Amano Haruka、Saiki Shinji、Fujimaki Motoki、Ueno Shin‐Ichi、Li Yuanzhe、Hatano Taku、Ishikawa Kei‐Ichi、Oji Yutaka、Mori Akio、Okuzumi Ayami、Tsunemi Taiji、Daida Kensuke、Ishiguro Yuta、Imamichi Yoko、Nanmo Hisayoshi、Nojiri Shuko、Funayama Manabu、Hattori Nobutaka
- Journal Title
  
  Movement Disorders
  
  Volume: 35 Issue: 8 Pages: 1438-1447
- DOI
  10.1002/mds.28068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-18K07510, KAKENHI-PROJECT-18KT0027
[Journal Article] Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations2020
- Author(s)
  Kano Masayoshi、Takanashi Masashi、Oyama Genko、Yoritaka Asako、Hatano Taku、Shiba-Fukushima Kahori、Nagai Makiko、Nishiyama Kazutoshi、Hasegawa Kazuko、Inoshita Tsuyoshi、Ishikawa Kei-ichi、Akamatsu Wado、Imai Yuzuru、Bolognin Silvia、Schwamborn Jens Christian、Hattori Nobutaka
- Journal Title
  
  npj Parkinson's Disease
  
  Volume: 6 Issue: 1 Pages: 33-33
- DOI
  10.1038/s41531-020-00137-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09765
[Journal Article] Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation2020
- Author(s)
  Tsunemi Taiji、Ishiguro Yuta、Yoroisaka Asako、Valdez Clarissa、Miyamoto Kengo、Ishikawa Keiichi、Saiki Shinji、Akamatsu Wado、Hattori Nobutaka、Krainc Dimitri
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 40 Issue: 45 Pages: 8618-8628
- DOI
  10.1523/jneurosci.0954-20.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K07510
[Journal Article] Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease2020
- Author(s)
  Yamaguchi Akihiro、Ishikawa Kei-ichi、Inoshita Tsuyoshi、Shiba-Fukushima Kahori、Saiki Shinji、Hatano Taku、Mori Akio、Oji Yutaka、Okuzumi Ayami、Li Yuanzhe、Funayama Manabu、Imai Yuzuru、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Reports
  
  Volume: 14 Issue: 6 Pages: 1060-1075
- DOI
  10.1016/j.stemcr.2020.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09765
[Journal Article] Mutations in CHCHD2 cause α-synuclein aggregation2019
- Author(s)
  Ikeda A., Nishioka K., Meng H., Takanashi M., Hasegawa I., Inoshita T., Shiba-Fukushima K., Li Y., Yoshino H., Mori A., Okuzumi A., Yamaguchi A., Nonaka R., Izawa N., Ishikawa K.I., Saiki H., Morita M., Hasegawa M., Hasegawa K., Elahi M., et al.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 28 Issue: 23 Pages: 3895-3911
- DOI
  10.1093/hmg/ddz241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K15463, KAKENHI-PROJECT-18K15465
[Journal Article] p150glued deficiency impairs effective fusion between autophagosomes and lysosomes due to their redistribution to the cell periphery.2019
- Author(s)
  Ishikawa-KI, Saiki S, Furuya N, Imamichi Y, Tsuboi Y, Hattori N
- Journal Title
  
  Neuroscience Letters
  
  Volume: 690 Pages: 181-187
- DOI
  10.1016/j.neulet.2018.10.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K15463, KAKENHI-PROJECT-18H02744
[Journal Article] Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy2019
- Author(s)
  Mori Akio、Ishikawa Kei-Ichi、Saiki Shinji、Hatano Taku、Oji Yutaka、Okuzumi Ayami、Fujimaki Motoki、Koinuma Takahiro、Ueno Shin-Ichi、Imamichi Yoko、Hattori Nobutaka
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 9 Pages: e0223113-e0223113
- DOI
  10.1371/journal.pone.0223113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18K15376, KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-18K15463
[Journal Article] Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson's Disease.2019
- Author(s)
  Valentine MNZ, Hashimoto K, Fukuhara T, Saiki S, Ishikawa KI, Hattori N, Carninci P.
- Journal Title
  
  Sci Data
  
  Volume: 6 Issue: 1 Pages: 1-7
- DOI
  10.1038/s41597-019-0022-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07831, KAKENHI-PROJECT-18K15463
[Journal Article] Neuroprotective effects of memantine via enhancement of autophagy2019
- Author(s)
  Hirano Kazuoki、Fujimaki Motoki、Sasazawa Yukiko、Yamaguchi Akihiro、Ishikawa Kei-Ichi、Miyamoto Kengo、Souma Sanae、Furuya Norihiko、Imamichi Yoko、Yamada Daisuke、Saya Hideyuki、Akamatsu Wado、Saiki Shinji、Hattori Nobutaka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 518 Issue: 1 Pages: 161-170
- DOI
  10.1016/j.bbrc.2019.08.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-18K15463, KAKENHI-PROJECT-18K15464
[Journal Article] Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease2018
- Author(s)
  Motoki Fujimaki, Shinji Saiki, Yuanzhe Li, Naoko Kaga, Taku Hatano, Kei-Ichi Ishikawa, Yutaka Oji, Akio Mori, Ayami Okuzumi, Takahiro Koinuma, Shin-Ichi Ueno, Yoko Imamichi, Takashi Ueno, Yoshiki Miura, Manabu Funayama
- Journal Title
  
  Neurology
  
  Volume: 90
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25111007
[Journal Article] Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease2018
- Author(s)
  Ren Qian、Ma Min、Yang Jun、Nonaka Risa、Yamaguchi Akihiro、Ishikawa Kei-ichi、Kobayashi Kenta、Murayama Shigeo、Hwang Sung Hee、Saiki Shinji、Akamatsu Wado、Hattori Nobutaka、Hammock Bruce D.、Hashimoto Kenji
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 25
- DOI
  10.1073/pnas.1802179115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K06535, KAKENHI-PROJECT-18K15463, KAKENHI-PUBLICLY-17H05706, KAKENHI-PROJECT-17H04243, KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-18K15439
[Journal Article] Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease.2018
- Author(s)
  Ueno SI, Saiki S, Fujimaki M, Takeshige-Amano H, Hatano T, Oyama G, Ishikawa KI, Yamguchi A, Nojiri S, Akamatsu W, Hattori N.
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 1 Pages: 14-14
- DOI
  10.3390/cells8010014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K15463, KAKENHI-PUBLICLY-17H05706, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09677
[Journal Article] Serum caffeine and metabolites are reliable biomarkers of early Parkinson’s disease.2018
- Author(s)
  3.Fujimaki M, Saiki S*, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N
- Journal Title
  
  Neurology
  
  Volume: 9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04843
[Journal Article] Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.2017
- Author(s)
  Saiki S, Hatano T, Fujimaki M, Ishikawa K, Mori A, Oji Y, Okuzumi A, Fukuhara T, Koinuma T, Nagumo M, Furuya N, Nojiri S, Amo T, Yamashiro K, Hattori N.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 7328-7328
- DOI
  10.1038/s41598-017-06767-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-17K09769, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-15H04843, KAKENHI-PROJECT-15K09325
[Journal Article] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease2017
- Author(s)
  Shiba-Fukushima Kahori、Ishikawa Kei-Ichi、Inoshita Tsuyoshi、Izawa Nana、Takanashi Masashi、Sato Shigeto、Onodera Osamu、Akamatsu Wado、Okano Hideyuki、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 3172-3185
- DOI
  10.1093/hmg/ddx201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-17K09765, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-16K15484, KAKENHI-PROJECT-16K19524, KAKENHI-PUBLICLY-17H05706
[Journal Article] Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons.2017
- Author(s)
  Suzuki S, Akamatsu W, Kisa F, Sone T, Ishikawa KI, Kuzumaki N, Katayama H, Miyawaki A, Hattori N, Okano H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 489 Issue: 1 Pages: 88-93
- DOI
  10.1016/j.bbrc.2016.12.188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-15K06924, KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-16K19524, KAKENHI-PROJECT-16K08280
[Journal Article] Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation.2015
- Author(s)
  Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 471 Issue: 1 Pages: 109-116
- DOI
  10.1016/j.bbrc.2016.01.171
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09325, KAKENHI-PUBLICLY-15H01388, KAKENHI-PLANNED-23111003, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-15H04843, KAKENHI-PROJECT-26893263, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-26660086, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-15H04842
[Journal Article] 疾患モデル細胞, iPS細胞を用いた毒性評価と創薬研究, iPS細胞を用いたパーキンソン病の態解析2015
- Author(s)
  石川景一、服部信孝、赤松和土
- Journal Title
  
  日本臨床増刊号
  
  Volume: 1080 Pages: 391-395
- Data Source
  KAKENHI-PROJECT-26893263
[Journal Article] P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway.2014
- Author(s)
  Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 4 Pages: e94645-e94645
- DOI
  10.1371/journal.pone.0094645
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-ORGANIZER-25111001, KAKENHI-PLANNED-25111007, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-25860725, KAKENHI-PUBLICLY-26111519
[Presentation] 中脳特異的ニューロスフェアを介した神経分化誘導法における長期継代・増幅の検討2024
- Author(s)
  野中里紗、石川景一、志賀孝宏、美濃部俊輝、服部信孝、赤松和土
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K06934
[Presentation] 疾患特異的iPS細胞と遺伝子情報を含む血液データとの融合による孤発性パーキンソン病の層別化2024
- Author(s)
  山口昂大、石川景一、斉木臣二、服部信孝、赤松和土
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K06934
[Presentation] 孤発性パーキンソン病iPS細胞由来神経細胞の表現型と相関する臨床バイオマーカーの探索2024
- Author(s)
  石川景一、山口昂大、斉木臣二、服部信孝、赤松和土
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K06934
[Presentation] フィーダーフリー iPS 細胞由来中脳特異ニューロスフェアを介するドーパミン作動性神経分化誘導法の特性評価2023
- Author(s)
  野中里紗、石川景一、志賀孝宏、美濃部俊輝、服部信孝、赤松和土
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] Phenotype-based classification of idiopathic Parkinson’s disease derived iPSCs and its application2023
- Author(s)
  山口昂大、石川景一、斉木臣二、服部信孝、赤松和土
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06934
[Presentation] 孤発性パーキンソン病iPS細胞の表現型に基づく層別化とその応用2023
- Author(s)
  山口昂大、石川景一、斉木臣二、服部信孝、赤松和土
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] Establishment of midbrain organoid induction method and phenotypic analysis for Parkinson’s disease.2022
- Author(s)
  Akihiro Yamaguchi, Mizuki Inage, Kei-ichi Ishikawa, Jens Schwamborn, Nobutaka Hattori, Wado Akamatsu.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] iPSC-based drug screening for PARK9, a familial Parkinson’s disease with impaired autophagy.2022
- Author(s)
  Kei-ichi Tsukiboshi, Kei-ichi Ishikawa, Akihiro Yamaguchi, Kimihito Arai, Kazuaki Kanai, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] Parkinson’s disease-linked prosaposin gene mutation affects intracellular trafficking and secretion of prosaposin.2022
- Author(s)
  Ryo Wakamori, Yutaka Oji, Taku Hatano, Kentaro Gejima, Ayami Okuzumi, Shin-ichi Ueno, Risa Nonaka, Kei-Ichi Ishikawa, Wado Akamatsu, Nobutaka Hattori
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] Rapid and efficient region-specific astrocyte induction from iPSCs without transcription factors2022
- Author(s)
  Takahiro Suzuki, Takahiro Shiga, Kei-ichi Ishikawa, Wado Akamatsu
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] Properties of midbrain-specific dopaminergic progenitors obtained with a neurosphere culture system2022
- Author(s)
  Risa Nonaka, Kei-ichi Ishikawa, Takahiro Shiga, Ryota Nakamura, Genko Oyama, Nobutaka Hattori, Wado Akamatsu
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] Investigation of clinical biomarkers correlating with the phenotype of dopaminergic neurons derived from iPS cells of patients with idiopathic Parkinson's disease.2022
- Author(s)
  Kei-ichi Ishikawa, Akihiro Yamaguchi, Shinji Saiki, Nobutaka Hattori, Wado Akamatsu.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] COMT is increased in iPSC-dopaminergic neurons with Parkinson's disease-linked prosaposin variant2022
- Author(s)
  Kentaro Gejima, Yutaka Oji, Ryo Wakamori, Risa Nonaka, Kei-Ichi Ishikawa, Shinichi-Ueno, Ayami Okuzumi, Taku Hatano, Wado Akamatsu, Nobutaka Hattori.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] Establishment of the in vitro disease model of Charcot-Marie-Tooth disease using hiPSCs.2022
- Author(s)
  Xing Liu, Kei-ichi Ishikawa, Nobutaka Hattori, Wado Akamatsu.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] iPSC-based disease modeling for late onset neurodegenerative diseases using a chemical compound accelerating senescence.2021
- Author(s)
  Takahiro Shiga, Sakura Miyoshi, Hidetaka Tamune, Avijite KumerSarkar, Kento Nakai, Naoko Kuzumaki, Ke-ichi Ishikawa, Kazuyoshi Baba, Shigeo Okabe, Nobutaka Hattori, Hideyuki Okano, Wado Akamatsu.
- Organizer
  ISSCR/JSRM 2021 Tokyo International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] Assessment of iPS cell-derived dopaminergic progenitor cells properties with long-term passaging and amplification.2021
- Author(s)
  Toshiki Minobe, Risa Nonaka, Takahiro Shiga, Kei-ichi Ishikawa, Nobutaka Hattori, Wado Akamatsu.
- Organizer
  ISSCR/JSRM 2021 Tokyo International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] RAPID AND EFFICIENT REGION SPECIFIC ASTROCYTE INDUCTION FROM HUMAN PLURIPOTENT STEM CELLS WITHOUT EXOGENOUS TRANSCRIPTION FACTORS.2021
- Author(s)
  Takahiro Suzuki, Takahiro Shiga, Kei-ichi Ishikawa, Wado Akamatsu.
- Organizer
  ISSCR/JSRM 2021 Tokyo International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07873
[Presentation] iPSC-based drug screening for PARK9, a familial Parkinson’s disease with impaired autophagy2019
- Author(s)
  Kei-ichi Tsukiboshi, Akihiro Yamaguchi, Kei-ichi Ishikawa, Kazuaki Kanai, Hideyuki Okano, Nobutala Hattori, Wado Akamatsu
- Organizer
  International Society for Stem Cell Research (ISSCR) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] 老化を加速する低分子化合物を用いた神経変性疾患iPS解析システムの構築2019
- Author(s)
  志賀孝宏, 三好さくら, 葛巻直子, 石川景一, 服部信孝, 岡野栄之, 赤松和土
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] パーキンソン病iPS細胞を用いた病態解明・創薬スクリーニング2019
- Author(s)
  山口昂大, 石川景一, 斉木臣二, 船山学, 金井数明, 岡野栄之, 服部信孝, 赤松和土
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] ゾニサミドはパーキンソン病患者において脂肪酸β酸化を改善する2019
- Author(s)
  上野真一, 斉木臣二, 藤巻基紀, 竹重遥香, 波田野琢, 大山彦光, 石川景一, 山口昂大, 野尻宗子, 赤松和土, 服部信孝
- Organizer
  第13回日本パーキンソン病・運動障害疾患学会
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] Identification of potential therapeutic agents for impaired mitophagy in Parkinson’s disease2019
- Author(s)
  Akihiro Yamaguchi, Kei-ichi Ishikawa, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Yuzuru Imai, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu
- Organizer
  International Society for Stem Cell Research (ISSCR) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] iPSC-based disease modeling for late onset neurodegenerative diseases using a chemical compound accelerating senescence.2019
- Author(s)
  Takahiro Shiga, Sakura Miyoshi, Naoko Kuzumaki, Ke-ichi Ishikawa, Nobutaka Hattori, Hideyuki Okano, Wado Akamatsu
- Organizer
  International Society for Stem Cell Research (ISSCR) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] フィーダーフリー培養系iPS細胞を用いた中脳特異ドパミン作動性ニューロンの分化誘導法の検討2019
- Author(s)
  野中里紗、石川景一、志賀孝宏、中村亮太、城崇之、大山彦光、服部信孝、赤松和土
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] フィーダーフリー培養系iPS細胞を用いた中脳特異的ドーパミン神経の分化誘導法の検討2018
- Author(s)
  野中里紗、石川景一、志賀孝宏、城崇之、中村亮太、大山彦光、斉木臣二、岡野栄之、服部信孝、赤松和土
- Organizer
  第17回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] ATM阻害はヒトiPS細胞由来神経細胞の老化を加速させる2018
- Author(s)
  志賀孝宏, 三好さくら, 葛巻直子, 石川景一, 服部信孝, 岡野栄之, 赤松和土
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] フィーダーフリー培養系iPS細胞を用いた中脳特異ドパミン作動性ニューロンの分化誘導法の検討2018
- Author(s)
  野中里紗、石川景一、志賀孝宏、城崇之、中村亮太、大山彦光、斉木臣二、岡野栄之、服部信孝、赤松和土
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] iPS細胞を用いた遺伝性パーキンソン病PARK9のAutophagy異常を改善する薬剤の探索2018
- Author(s)
  月星慶一、山口昂大、石川景一、金井数明、岡野栄之、服部信孝、赤松和土
- Organizer
  第17回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] iPS細胞を用いた遺伝性パーキンソン病PARK14, PARK22の病態解析2018
- Author(s)
  津川直輝、山口昂大、石川景一、志賀孝宏、舩山学、波田野琢、木村活生、岡野栄之、服部信孝、赤松和土
- Organizer
  第17回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] 家族性パーキンソン病iPS細胞由来神経細胞における細胞特異的表現型のハイスループット解析法の確立と病態解明2018
- Author(s)
  山口昂大、石川景一、藤森康希、斉木臣二、金井和明、舩山学、岡野栄之、服部信孝、赤松和土
- Organizer
  第17回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] 老化を加速する低分子化合物を用いた神経変性疾患iPS解析システムの構築2018
- Author(s)
  志賀孝宏, 三好さくら, 葛巻直子, 石川景一, 服部信孝, 岡野栄之, 赤松和土
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K15463
[Presentation] フィーダーフリー培養系iPS細胞を用いた中脳特異的神経細胞分化誘導法の検討2017
- Author(s)
  野中里沙、石川景一、志賀孝宏、斉木臣二、岡野栄之、服部信孝、赤松和土
- Organizer
  第16回日本再生医療学会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] 神経変性疾患iPS細胞モデルの表現型の発現を加速する低分子化合物の探索と評価2017
- Author(s)
  志賀孝宏、三好さくら、葛巻直子、石川景一、服部信孝、岡野栄之、赤松和土
- Organizer
  第16回日本再生医療学会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] A high-throughput disease-specific phenotype detection system of Parkinson’s disease for drug screening2017
- Author(s)
  Kei-ichi Ishikawa, Akihiro Yamaguchi, Koki Fujimori, Hideyuki Okano, Nobutaka Hattori, Wado Akamastu
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] パーキンソン病患者iPS由来ドパミン神経細胞を用いた神経保護化合物の薬効評価2017
- Author(s)
  寺尾梢、志賀孝宏、山口昂大、田代悦、石川景一、斉木臣二、岡野栄之、服部信孝、井本正哉、赤松和土
- Organizer
  第16回日本再生医療学会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] パーキンソン病iPS細胞由来神経細胞を用いた創薬スクリーニング：アッセイ系の構築とその利用2017
- Author(s)
  山口昂大、石川景一、藤森康希、岡野栄之、服部信孝、赤松和土
- Organizer
  第16回日本再生医療学会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] A high throughput assay system to detect mitophagy in iPSC-derived neurons from Parkinson’s disease.2016
- Author(s)
  Kei-ichi Ishikawa, Akihiro Yamaguchi, Koki Fujimori, Keiko Sakai, Hideyuki Okano, Nobutaka Hattori, Wado Akamastu.
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K19524
[Presentation] オートファジー調節作用を持つ薬剤の探索 -既存薬ライブラリーを用いて-2014
- Author(s)
  平野一興、斉木臣二、古屋徳彦、山田大介、石川景一、佐谷秀行、服部信孝
- Organizer
  厚生労働科学研究委託事業　難治性疾患等克服研究事業　「パーキンソン病患者由来iPS細胞を中心とする多面的疾患モデルに立脚した革新的医薬品の開発」　第2回班会議
- Place of Presentation
  順天堂大学10号館1階会議室、東京
- Year and Date
  2014-12-18
- Data Source
  KAKENHI-PLANNED-25111007
[Presentation] ペリー症候群の分子病態とアポトーシスの関係2014
- Author(s)
  石川景一, 斉木臣二, 古屋徳彦, 山田大介, 今道洋子, 李元哲, 河尻澄宏, 佐々木寛典, 小池正人, 坪井義夫，服部信孝
- Organizer
  カテコールアミンと神経疾患研究会 2014
- Place of Presentation
  品川プリンスホテル
- Year and Date
  2014-04-19
- Data Source
  KAKENHI-PLANNED-25111007
[Presentation] 抗結核薬エタンブトールのオートファジー阻害作用
- Author(s)
  山田大介, 斉木臣二, 古屋徳彦, 石川景一, 今道洋子, 神戸大朋, 藤村務, 上野隆, 小池正人, 服部信孝
- Organizer
  第8回オートファジー研究会・第2回新学術「オートファジー」班会議
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26893263
[Presentation] 抗結核薬エタンブトールのオートファジー阻害作用
- Author(s)
  山田大介, 斉木臣二, 古屋徳彦, 石川景一, 今道洋子, 神戸大朋, 藤村務, 上野隆, 小池正人, 服部信孝
- Organizer
  第8回オートファジー研究会
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ北海道、札幌
- Year and Date
  2014-11-09 – 2014-11-12
- Data Source
  KAKENHI-PLANNED-25111007
[Presentation] ペリー症候群の原因遺伝子DCTN1欠損によるオートファジー障害の検討
- Author(s)
  石川景一
- Organizer
  第8回オートファジー研究会・第2回新学術「オートファジー」班会議
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26893263

1. Shinji Saiki (00339996)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. SASAZAWA Yukiko (20594922)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
3. AKAMATSU WADO (60338184)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
4. IMOTO Masaya (60213253)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. FURUYA Norihiko (50401188)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. FUNAYAMA Manabu (70468578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. YAMADA Daisuke (30757539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 住吉克彦 (10445471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 福原武志 (20359673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 佐藤栄人 (00445537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 天羽拓 (40453922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 野中里紗 (90614248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 志賀孝宏 (50784378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 清田純 (40793790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 太田禎生 (70731214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TORII Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. HATANO Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 西岡健弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 田代悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 横田睦美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 加茂晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 岡野栄之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishikawa Kei-ichi 石川 景一

Research Projects

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Co-Researchers

パーキンソン病iPS細胞を用いたαシヌクレインによる自律神経病態の解明Principal Investigator

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Classification of sporadic Parkinson's disease from patient iPS cell phenotypes

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神経変性疾患由来iPS細胞を用いたin vitro血液脳関門モデル構築と病態解析

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Generation of an aged Parkinson's disease brain model and elucidation of its pathophysiology using iPS cellsPrincipal Investigator

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Research on PD pathogenesis based on polyamine metabolism using multiomics analysis

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Elucidation of the mechanism of Parkinson's disease iPS cell-derived dopaminergic nerurons due to agingPrincipal Investigator

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Identification of Parkinson disease-specific mitochondrial pathogenesis for disease-modifying therapy

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Identification of Parkinson's disease progression markers based on skeletal muscle-brain axis

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Establishment of dopamine neuron specific disease model using iPS cells derived from hereditary Parkinson's diseasesPrincipal Investigator

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Development of anti-PD chemicals modulating autophagic activity based on lysosomal function

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Analysis of autophagic impairment in neurons derived from familial parkinson's diseasePrincipal Investigator

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Development of autophagy enhancing chemicals based on Parkinson's disease pathogenesis.

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[Journal Article] Generation of one induced pluripotent stem cell line JUCGRMi004-A from a Charcot-Marie-Tooth disease type 1A (CMT1A) patient with PMP22 duplication2024

Author(s)

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DOI

Ishikawa Kei-ichi 石川景一