Itoh-Nakadai Ari 伊藤亜里

Researcher Number	90749772
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 日本医科大学, 医学部, 助教 2022 – 2023: 日本医科大学, 医学部, 助教 2021: 国立研究開発法人理化学研究所, 生命医科学研究センター, 客員研究員 2018 – 2020: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2015 – 2017: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / General medical chemistry / Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Medium-sized Section 48:Biomedical structure and function and related fields / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords	Principal Investigator CXCR4 / 急性骨髄性白血病 / 骨髄 / 免疫学 / メタロチオネイン / 形質細胞 / 抗体産生 / 獲得免疫 / Bach2 / 転写因子 … More / 血球分化 / 低酸素 / がん細胞治療 / キメラ抗原受容体T細胞（CAR-T) / 急性骨髄性白血病（AML) / 免疫疲弊 / 急性骨髄性白血病(AML) / キメラ抗原受容体-T(CAR-T) / 予後不良 / CD25 / AML治療 / CAR-T療法 / 腫瘍免疫 / キメラ抗原受容体T細胞 / 白血病 / T細胞 / BACH2 / C/EBPa / AML / 遺伝子発現 / 細胞寿命 / 抗体アイソタイプ / １細胞網羅的遺伝子発現解析 / 骨髄ニッチ / 組織特異的 / MT / 長寿命形質細胞 / 脾臓形質細胞 / 骨髄形質細胞 / 長期生存形質細胞 / 単一細胞解析 / 長寿命 / RNA-Seq / 単一細胞遺伝子解析 / 細胞長期生存 / １細胞RNA-Seq / 長期生存細胞 / 亜鉛 / 免疫記憶 / 前駆細胞 / 造血幹細胞 / 造血多能性前駆細胞 / コミットメント / 遺伝子発現制御 … More Except Principal Investigator オミックス / B細胞 / 抗体 / 鉄 / 転写因子 / NRF2 / 酸化ストレス/抗酸化ストレス / 微小粒子物質 / 血管内皮細胞 Less

Elucidating the role of iron metabolism in humoral immunity regulation
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
Analysis of CXCR4-Expressing Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Acute Myeloid LeukemiaPrincipal Investigator
- Principal Investigator
  
  伊藤亜里
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nippon Medical School
NRF2欠損内皮細胞を用いたPM2.5の血管障害の分子メカニズムの解明
- Principal Investigator
  
  李英姫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Nippon Medical School
急性骨髄性白血病治療に特化したCXCR4発現CD25標的キメラT細胞の解析Principal Investigator
- Principal Investigator
  
  伊藤亜里
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nippon Medical School
Functional elucidation of transcription factor Bach2 in the development and maintenance of acute myeloid leukemiaPrincipal Investigator
- Principal Investigator
  
  Itoh-Nakadai Ari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of the acquisition mechanism of a long life in plasma cellsPrincipal Investigator
- Principal Investigator
  
  Itoh-Nakadai Ari
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Institute of Physical and Chemical Research
  Tohoku University
A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitorsPrincipal Investigator
- Principal Investigator
  
  Itoh-Nakadai Ari
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Regulation of lineage fate in hematopoietic stem cells by Bach2(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  Ari Itoh-Nakadai
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 遺伝子治療開発研究ハンドブック　第２版2023
- Author(s)
  伊藤亜里、石川文彦
- Total Pages
  772
- Publisher
  NTS
- ISBN
  9784860438401
- Data Source
  KAKENHI-PROJECT-22K07243
[Journal Article] Bone marrow PDGFRa+Sca-1+ enriched mesenchymal stem cells support survival of and antibody production by plasma cells in vitro through IL-6.2018
- Author(s)
  Atsuko Kayaba, Ari Itoh-Nakadai, Kunimichi Niibe, Matsuyuki Shirota, Ryo Funayama, Akiko Sugahara-Tobinai, Yi Li Wong, Masanori Inui, Keiko Nakayama, and Toshiyuki Takai.
- Journal Title
  
  Int Immu
  
  Volume: in press Issue: 6 Pages: 241-253
- DOI
  10.1093/intimm/dxy018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19539, KAKENHI-PROJECT-17K15714, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-15KK0328, KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-16K20480
[Journal Article] A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitors.2017
- Author(s)
  Itoh-Nakadai, A., Matsumoto, M., Kato, H., Sasaki, J., Uehara, Y., Sato, Y., Ebina-Shibuya, R., Morooka, M., Funayama, R., Nakayama, K., Ochiai, K., Muto, A. and Igarashi, K.
- Journal Title
  
  Cell Reports
  
  Volume: 18 Issue: 10 Pages: 2401-2414
- DOI
  10.1016/j.celrep.2017.02.029
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-16K14664, KAKENHI-PROJECT-15K18998, KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-16K07108, KAKENHI-PROJECT-15KK0328
[Journal Article] Orchestration of B lymphoid cells and their inner myeloid by Bach2016
- Author(s)
  Kazuhiko Igarashi, Ari Itoh-Nakadai
- Journal Title
  
  Current Opinion Immunology
  
  Volume: 39 Pages: 136-142
- DOI
  10.1016/j.coi.2016.01.012
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18998
[Presentation] キメラ抗原受容体T細胞治療時の組織依存的な代謝機構の解明2023
- Author(s)
  伊藤亜里、富澤麻利子、梶田博志、鈴木那穂子、反町優理子、小林麻衣子、清水孝子、松本武久、白水美香子、田久保圭誉、齊藤頼子、石川文彦
- Organizer
  第96会日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K07243
[Presentation] Elucidating Tissue-Specific Metabolisms in Chimeric Antigen Receptor T-Cell Therapy2023
- Author(s)
  Ari Itoh-Nakadai, Mariko Murasawa-Tomizawa, Matsuda Masashi, Koseki Haruhiko, Fumihiko Ishikawa
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07243
[Presentation] Targeting poor prognosis leukemia with CD25-targeted chemokine receptor expressing CAR T cell therapy2022
- Author(s)
  Ari Itoh-Nakadai, Mariko Murasawa-Tomizawa, Masashi Matsuda, Haruhiko Koseki, Fumihiko Ishikawa
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07243
[Presentation] 動物モデルによるAMLの病態および治療法の解明2022
- Author(s)
  伊藤亜里
- Organizer
  第84回日本血液学会学術集会　教育講演
- Invited
- Data Source
  KAKENHI-PROJECT-22K07243
[Presentation] Targeting poor prognosis leukemia with CD25-targeted chemokine receptor expressing CAR-T cell therapy2022
- Author(s)
  Ari Itoh-Nakadai, Yoriko Saito, Mariko Murasawa-Tomizawa, Hiroshi Kajita, Ikuko Ogahara, Saera Fujiki, Nahoko Suzuki, Takehisa Matsumoto, Masashi Matsuda, Yuriko Sorimachi, Shinsuke Takagi, Mikako Shirouzu, Uchida Naoyuki, Keiyo Takubo, Haruhiko Koseki, Shultz Leonard, Shuichi Taniguchi, Fumihiko Ishikawa
- Organizer
  第84回日本血液学会学術集会　一般講演
- Data Source
  KAKENHI-PROJECT-22K07243
[Presentation] 急性骨髄性白血病の予後不良因子CD25を標的としたケモカイン受容体発現CAR-T細胞の開発2021
- Author(s)
  伊藤亜里
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07630
[Presentation] The examination of chemokine receptor for targeting poor prognosis leukemia with CD25-targeted CAR T cell therapy2021
- Author(s)
  Ari Itoh-Nakadai, Yoriko Saito, Fumihiko Ishikawa
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07630
[Presentation] CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo2020
- Author(s)
  Ari Itoh-Nakadai, Yoriko Saito, Mariko Murasawa-Tomizawa, Hiroshi Kajita, Takehisa Matsumoto, Masashi Matsuda, Takashi Watanabe, Mikako Shirouzu Osamu Ohara, Haruhiko Koseki, Leonard Shultz and Fumihiko Ishikawa
- Organizer
  62nd ASH annual meeting and exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07630
[Presentation] Creation of HLA class I and class II Tg NOD/SCID/Il2rgKO (NSG) mice for studying interaction between human immunity and leukemia2019
- Author(s)
  Ari Itoh-Nakadai, Yuho Najima, Rintaro Ono, Masashi Mastuda, Kaori Sato1, Mariko Murasawa-Tomizawa, Osamu Ohara, Haruhiko Koseki, Fumihiko Ishikawa
- Organizer
  第48回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07630
[Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017
- Author(s)
  Itoh-Nakadai A, Kayaba A and Takai T
- Organizer
  5th Annual meeting of the international cytokine & interferon society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0328
[Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017
- Author(s)
  Ari Itoh-Nakadai, Toshiyuki Takai
- Organizer
  The Inaugural Chiba University - UC San Diego Symposium on Mucosal Immunology, Allergy and Vaccines: Impact on Mucosal Diseases and Global Health
- Place of Presentation
  San Diego, USA
- Year and Date
  2017-02-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0328
[Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017
- Author(s)
  Itoh-Nakadai A, Kayaba A and Takai T
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0328
[Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017
- Author(s)
  Itoh-Nakadai A, Kayaba A and Takai T
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15KK0328
[Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017
- Author(s)
  Itoh-Nakadai A, Kayaba A and Takai T
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15714
[Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017
- Author(s)
  Ari Itoh-Nakadai, Toshiyuki Takai
- Organizer
  Keystone Symposia: B Cells and T Follicular Helper Cells -Controlling Long-Lived Immunity (D2)
- Place of Presentation
  British Columbia, Canada
- Year and Date
  2017-04-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0328
[Presentation] 長寿命形質細胞の免疫記憶維持の解明2017
- Author(s)
  伊藤亜里、萱場敦子、高井俊行
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-17K15714
[Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017
- Author(s)
  Itoh-Nakadai A, Kayaba A and Takai T
- Organizer
  5th Annual meeting of the international cytokine & interferon society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15714
[Presentation] 長寿命形質細胞の免疫記憶維持の解明2017
- Author(s)
  伊藤亜里、萱場敦子、高井俊行
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-15KK0328
[Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017
- Author(s)
  Itoh-Nakadai A, Kayaba A and Takai T
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15714
[Presentation] Bach2 represses myeloid programs to promote lymphoid progenitor development under both the steady state and infection2015
- Author(s)
  Ari Itoh-Nakadai, Kazuhiko Igarashi
- Organizer
  第44回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K18998
[Presentation] Bach2 represses myeloid programs to promote lymphoid progenitor development under both the steady state and infection2015
- Author(s)
  Ari Itoh-Nakadai
- Organizer
  The 3rd Symposium of International Immunological Memory and Vaccine Forum
- Place of Presentation
  ベルリン日独センター（ドイツ・ベルリン）
- Year and Date
  2015-10-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18998

1. 李英姫 (60350039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 川田智之 (00224791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 平田幸代 (40322515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 加藤活人 (40409157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 稲垣弘文 (50213111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 五十嵐和彦 (00250738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. McHeyzer-Williams Michael

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高井俊行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Itoh-Nakadai Ari 伊藤 亜里

Research Projects

Research Products

Co-Researchers

Elucidating the role of iron metabolism in humoral immunity regulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of CXCR4-Expressing Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Acute Myeloid LeukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NRF2欠損内皮細胞を用いたPM2.5の血管障害の分子メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

急性骨髄性白血病治療に特化したCXCR4発現CD25標的キメラT細胞の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional elucidation of transcription factor Bach2 in the development and maintenance of acute myeloid leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the acquisition mechanism of a long life in plasma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of lineage fate in hematopoietic stem cells by Bach2(Fostering Joint International Research)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 遺伝子治療開発研究ハンドブック 第２版2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Bone marrow PDGFRa+Sca-1+ enriched mesenchymal stem cells support survival of and antibody production by plasma cells in vitro through IL-6.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitors.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Orchestration of B lymphoid cells and their inner myeloid by Bach2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] キメラ抗原受容体T細胞治療時の組織依存的な代謝機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] Elucidating Tissue-Specific Metabolisms in Chimeric Antigen Receptor T-Cell Therapy2023

Author(s)

Organizer

Itoh-Nakadai Ari 伊藤亜里

[Book] 遺伝子治療開発研究ハンドブック　第２版2023