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Itoh-Nakadai Ari  伊藤 亜里

ORCIDConnect your ORCID iD *help
Researcher Number 90749772
Other IDs
Affiliation (Current) 2025: 日本医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2025: 日本医科大学, 医学部, 助教
2022 – 2023: 日本医科大学, 医学部, 助教
2021: 国立研究開発法人理化学研究所, 生命医科学研究センター, 客員研究員
2018 – 2020: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
2015 – 2017: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / General medical chemistry / Basic Section 49070:Immunology-related / Immunology
Except Principal Investigator
Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords
Principal Investigator
急性骨髄性白血病 / 骨髄 / 免疫学 / メタロチオネイン / 形質細胞 / 抗体産生 / 獲得免疫 / Bach2 / 転写因子 / 血球分化 … More / 免疫疲弊 / 急性骨髄性白血病(AML) / キメラ抗原受容体-T(CAR-T) / 予後不良 / CD25 / AML治療 / CAR-T療法 / 腫瘍免疫 / CXCR4 / キメラ抗原受容体T細胞 / 白血病 / T細胞 / BACH2 / C/EBPa / AML / 遺伝子発現 / 細胞寿命 / 抗体アイソタイプ / 1細胞網羅的遺伝子発現解析 / 骨髄ニッチ / 組織特異的 / MT / 長寿命形質細胞 / 脾臓形質細胞 / 骨髄形質細胞 / 長期生存形質細胞 / 単一細胞解析 / 長寿命 / RNA-Seq / 単一細胞遺伝子解析 / 細胞長期生存 / 1細胞RNA-Seq / 長期生存細胞 / 亜鉛 / 免疫記憶 / 前駆細胞 / 造血幹細胞 / 造血多能性前駆細胞 / コミットメント / 遺伝子発現制御 … More
Except Principal Investigator
NRF2 / 酸化ストレス/抗酸化ストレス / 微小粒子物質 / 血管内皮細胞 Less
  • Research Projects

    (7 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (8 People)
  •  急性骨髄性白血病治療に特化したCXCR4発現キメラ抗原受容体(CAR)T細胞の解析Principal Investigator

    • Principal Investigator
      伊藤 亜里
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nippon Medical School
  •  NRF2欠損内皮細胞を用いたPM2.5の血管障害の分子メカニズムの解明

    • Principal Investigator
      李 英姫
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58020:Hygiene and public health-related: including laboratory approach
    • Research Institution
      Nippon Medical School
  •  急性骨髄性白血病治療に特化したCXCR4発現CD25標的キメラT細胞の解析Principal Investigator

    • Principal Investigator
      伊藤 亜里
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nippon Medical School
  •  Functional elucidation of transcription factor Bach2 in the development and maintenance of acute myeloid leukemiaPrincipal Investigator

    • Principal Investigator
      Itoh-Nakadai Ari
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Elucidation of the acquisition mechanism of a long life in plasma cellsPrincipal Investigator

    • Principal Investigator
      Itoh-Nakadai Ari
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Institute of Physical and Chemical Research
      Tohoku University
  •  A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitorsPrincipal Investigator

    • Principal Investigator
      Itoh-Nakadai Ari
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tohoku University
  •  Regulation of lineage fate in hematopoietic stem cells by Bach2(Fostering Joint International Research)Principal Investigator

    • Principal Investigator
      Ari Itoh-Nakadai
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • Research Field
      General medical chemistry
    • Research Institution
      Tohoku University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 遺伝子治療開発研究ハンドブック 第2版2023

    • Author(s)
      伊藤亜里、石川文彦
    • Total Pages
      772
    • Publisher
      NTS
    • ISBN
      9784860438401
    • Data Source
      KAKENHI-PROJECT-22K07243
  • [Journal Article] Bone marrow PDGFRa+Sca-1+ enriched mesenchymal stem cells support survival of and antibody production by plasma cells in vitro through IL-6.2018

    • Author(s)
      Atsuko Kayaba, Ari Itoh-Nakadai, Kunimichi Niibe, Matsuyuki Shirota, Ryo Funayama, Akiko Sugahara-Tobinai, Yi Li Wong, Masanori Inui, Keiko Nakayama, and Toshiyuki Takai.
    • Journal Title

      Int Immu

      Volume: in press Issue: 6 Pages: 241-253

    • DOI

      10.1093/intimm/dxy018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19539, KAKENHI-PROJECT-17K15714, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-15KK0328, KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-16K20480
  • [Journal Article] A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitors.2017

    • Author(s)
      Itoh-Nakadai, A., Matsumoto, M., Kato, H., Sasaki, J., Uehara, Y., Sato, Y., Ebina-Shibuya, R., Morooka, M., Funayama, R., Nakayama, K., Ochiai, K., Muto, A. and Igarashi, K.
    • Journal Title

      Cell Reports

      Volume: 18 Issue: 10 Pages: 2401-2414

    • DOI

      10.1016/j.celrep.2017.02.029

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-16K14664, KAKENHI-PROJECT-15K18998, KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-16K07108, KAKENHI-PROJECT-15KK0328
  • [Journal Article] Orchestration of B lymphoid cells and their inner myeloid by Bach2016

    • Author(s)
      Kazuhiko Igarashi, Ari Itoh-Nakadai
    • Journal Title

      Current Opinion Immunology

      Volume: 39 Pages: 136-142

    • DOI

      10.1016/j.coi.2016.01.012

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K18998
  • [Presentation] キメラ抗原受容体T細胞治療時の組織依存的な代謝機構の解明2023

    • Author(s)
      伊藤亜里、富澤麻利子、梶田博志、鈴木那穂子、反町優理子、小林麻衣子、清水孝子、松本 武久、白水美香子、田久保圭誉、齊藤 頼子、石川 文彦
    • Organizer
      第96会日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-22K07243
  • [Presentation] Elucidating Tissue-Specific Metabolisms in Chimeric Antigen Receptor T-Cell Therapy2023

    • Author(s)
      Ari Itoh-Nakadai, Mariko Murasawa-Tomizawa, Matsuda Masashi, Koseki Haruhiko, Fumihiko Ishikawa
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K07243
  • [Presentation] Targeting poor prognosis leukemia with CD25-targeted chemokine receptor expressing CAR T cell therapy2022

    • Author(s)
      Ari Itoh-Nakadai, Mariko Murasawa-Tomizawa, Masashi Matsuda, Haruhiko Koseki, Fumihiko Ishikawa
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K07243
  • [Presentation] 動物モデルによるAMLの病態および治療法の解明2022

    • Author(s)
      伊藤亜里
    • Organizer
      第84回 日本血液学会学術集会 教育講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K07243
  • [Presentation] Targeting poor prognosis leukemia with CD25-targeted chemokine receptor expressing CAR-T cell therapy2022

    • Author(s)
      Ari Itoh-Nakadai, Yoriko Saito, Mariko Murasawa-Tomizawa, Hiroshi Kajita, Ikuko Ogahara, Saera Fujiki, Nahoko Suzuki, Takehisa Matsumoto, Masashi Matsuda, Yuriko Sorimachi, Shinsuke Takagi, Mikako Shirouzu, Uchida Naoyuki, Keiyo Takubo, Haruhiko Koseki, Shultz Leonard, Shuichi Taniguchi, Fumihiko Ishikawa
    • Organizer
      第84回 日本血液学会学術集会 一般講演
    • Data Source
      KAKENHI-PROJECT-22K07243
  • [Presentation] 急性骨髄性白血病の予後不良因子CD25を標的としたケモカイン受容体発現CAR-T細胞の開発2021

    • Author(s)
      伊藤亜里
    • Organizer
      第94回 日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07630
  • [Presentation] The examination of chemokine receptor for targeting poor prognosis leukemia with CD25-targeted CAR T cell therapy2021

    • Author(s)
      Ari Itoh-Nakadai, Yoriko Saito, Fumihiko Ishikawa
    • Organizer
      第80回 日本癌学会
    • Data Source
      KAKENHI-PROJECT-19K07630
  • [Presentation] CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo2020

    • Author(s)
      Ari Itoh-Nakadai, Yoriko Saito, Mariko Murasawa-Tomizawa, Hiroshi Kajita, Takehisa Matsumoto, Masashi Matsuda, Takashi Watanabe, Mikako Shirouzu Osamu Ohara, Haruhiko Koseki, Leonard Shultz and Fumihiko Ishikawa
    • Organizer
      62nd ASH annual meeting and exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07630
  • [Presentation] Creation of HLA class I and class II Tg NOD/SCID/Il2rgKO (NSG) mice for studying interaction between human immunity and leukemia2019

    • Author(s)
      Ari Itoh-Nakadai, Yuho Najima, Rintaro Ono, Masashi Mastuda, Kaori Sato1, Mariko Murasawa-Tomizawa, Osamu Ohara, Haruhiko Koseki, Fumihiko Ishikawa
    • Organizer
      第48回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07630
  • [Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017

    • Author(s)
      Itoh-Nakadai A, Kayaba A and Takai T
    • Organizer
      5th Annual meeting of the international cytokine & interferon society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KK0328
  • [Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017

    • Author(s)
      Ari Itoh-Nakadai, Toshiyuki Takai
    • Organizer
      The Inaugural Chiba University - UC San Diego Symposium on Mucosal Immunology, Allergy and Vaccines: Impact on Mucosal Diseases and Global Health
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2017-02-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KK0328
  • [Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017

    • Author(s)
      Itoh-Nakadai A, Kayaba A and Takai T
    • Organizer
      Keystone symposia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KK0328
  • [Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017

    • Author(s)
      Itoh-Nakadai A, Kayaba A and Takai T
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15KK0328
  • [Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017

    • Author(s)
      Itoh-Nakadai A, Kayaba A and Takai T
    • Organizer
      Keystone symposia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15714
  • [Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017

    • Author(s)
      Ari Itoh-Nakadai, Toshiyuki Takai
    • Organizer
      Keystone Symposia: B Cells and T Follicular Helper Cells -Controlling Long-Lived Immunity (D2)
    • Place of Presentation
      British Columbia, Canada
    • Year and Date
      2017-04-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KK0328
  • [Presentation] 長寿命形質細胞の免疫記憶維持の解明2017

    • Author(s)
      伊藤亜里、萱場敦子、高井俊行
    • Organizer
      第3回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-17K15714
  • [Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017

    • Author(s)
      Itoh-Nakadai A, Kayaba A and Takai T
    • Organizer
      5th Annual meeting of the international cytokine & interferon society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15714
  • [Presentation] 長寿命形質細胞の免疫記憶維持の解明2017

    • Author(s)
      伊藤亜里、萱場敦子、高井俊行
    • Organizer
      第3回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-15KK0328
  • [Presentation] Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells2017

    • Author(s)
      Itoh-Nakadai A, Kayaba A and Takai T
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K15714
  • [Presentation] Bach2 represses myeloid programs to promote lymphoid progenitor development under both the steady state and infection2015

    • Author(s)
      Ari Itoh-Nakadai, Kazuhiko Igarashi
    • Organizer
      第44回日本免疫学会総会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15K18998
  • [Presentation] Bach2 represses myeloid programs to promote lymphoid progenitor development under both the steady state and infection2015

    • Author(s)
      Ari Itoh-Nakadai
    • Organizer
      The 3rd Symposium of International Immunological Memory and Vaccine Forum
    • Place of Presentation
      ベルリン日独センター(ドイツ・ベルリン)
    • Year and Date
      2015-10-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18998
  • 1.  李 英姫 (60350039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  川田 智之 (00224791)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  平田 幸代 (40322515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  加藤 活人 (40409157)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  稲垣 弘文 (50213111)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  McHeyzer-Williams Michael
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  五十嵐 和彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  高井 俊行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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