Ishiguro Kazuya 石黒一也

… Alternative Names

石黒一也イシグロカズヤ

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Researcher Number	90784439
Affiliation (Current)	2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 札幌医科大学, 医学部, 助教 2019 – 2021: 札幌医科大学, 医学部, 訪問研究員 2016 – 2017: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related / Hematology
Keywords	Principal Investigator 多発性骨髄腫 / ヒストンメチル化 / DOT1L Except Principal Investigator 腫瘍免疫 / 細胞外マトリックス / がん線維芽細胞 / 腫瘍微小環境 / ゲノム / エピジェネッティック / メチル化 / ヒストンメチル化 / エピジェネティクス / 多発性骨髄腫

大腸癌微小環境における癌線維芽細胞の活性化とCD8陽性T細胞浸潤抑制の病態解明
- Principal Investigator
  
  山本英一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Sapporo Medical University
自然免疫応答に着目した多発性骨髄腫の新規エピジェネティック治療の開発Principal Investigator
- Principal Investigator
  
  石黒一也
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Sapporo Medical University
Development of a new myeloma therapy targeting DOT1LPrincipal Investigator
- Principal Investigator
  
  Ishiguro Kazuya
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Sapporo Medical University
Genome methylation approach to search mechanisms of malignancy and new therapeutic targets in multiple myeloma
- Principal Investigator
  
  ISHIDA Tadao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Sapporo Medical University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis.2021
- Author(s)
  Ishiguro K, Kitajima H, Niinuma T, Maruyama R, Nishiyama N, Ohtani H, Sudo G, Toyota M, Sasaki H, Yamamoto E, Kai M, Nakase H, Suzuki H.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 7-7
- DOI
  10.1038/s41420-020-00400-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17836, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-20K17057, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-21K15556
[Journal Article] Decrease of B-type natriuretic peptide to less than 200 pg/mL predicts longer survival in cardiac immunoglobulin light chain amyloidosis.2015
- Author(s)
  Ishiguro K, Hayashi T, Igarashi T, Maruyama Y, Ikeda H, Ishida T, Shinomura Y.
- Journal Title
  
  Int J Hematol.
  
  Volume: 102 Issue: 2 Pages: 200-204
- DOI
  10.1007/s12185-015-1814-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09456
[Journal Article] Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing.2015
- Author(s)
  Ikeda H, Ishiguro K, Igarashi T, Aoki Y, Hayashi T, Ishida T, Sasaki Y, Tokino T, Shinomura Y.
- Journal Title
  
  Onco Targets Ther.
  
  Volume: 8 Pages: 2805-2815
- DOI
  10.2147/ott.s86515
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09456, KAKENHI-PROJECT-26460944
[Presentation] 多発性骨髄腫においてDOT1L阻害は免疫シグナルを活性化する2022
- Author(s)
  石黒　一也
- Organizer
  第125回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] DOT1L inhibition activates immunologic signatures in multiple myeloma2022
- Author(s)
  石黒　一也
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Development of a new epigenetic immunotherapy for multiple myeloma2021
- Author(s)
  石黒一也
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Dual inhibition of EZH2 and G9a suppresses multiple myeloma cell proliferation by affecting interferon signaling2021
- Author(s)
  石黒一也
- Organizer
  第46回日本骨髄腫学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Dual inhibition of EZH2 and G9a suppresses multiple myeloma cell proliferation by affecting interferon signaling2021
- Author(s)
  石黒一也
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] The anti-myeloma effect of dual EZH2 and G9a inhibition2021
- Author(s)
  石黒一也
- Organizer
  第83回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] EZH2とG9aの共阻害はインターフェロンシグナルの活性化とIRF-4-MYC axisの抑制により多発性骨髄腫細胞の増殖を抑制する2020
- Author(s)
  石黒一也
- Organizer
  第121回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Development of a new combinational epigenetic treatment for multiple myeloma2020
- Author(s)
  石黒一也
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] 多発性骨髄腫における新規エピジェネティック併用療法の開発2019
- Author(s)
  石黒一也
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] Development of a new combinational epigenetic therapy of multiple myeloma2019
- Author(s)
  Kazuya Ishiguro
- Organizer
  第38回札幌国際がんシンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] 多発性骨髄腫に対するDOT1L阻害の抗腫瘍効果の解析2019
- Author(s)
  石黒一也
- Organizer
  第120回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] 多発性骨髄腫に対するDOT1L阻害の抗腫瘍効果の検討2019
- Author(s)
  石黒一也
- Organizer
  第5回がんゲノム・エピゲノム研究会
- Data Source
  KAKENHI-PROJECT-19K17836
[Presentation] The histone methyltransferase DOT1L is a potential therapeutic target in multiple myeloma2018
- Author(s)
  Kazuya Ishiguro, Hiroshi Kitajima, Takeshi Niinuma, Tadao Ishida, Reo Maruyama, Hiroshi Ikeda, Toshiaki Hayashi, Hajime Sasaki, Hideki Wakasugi, Koyo Nishiyama, Tetsuya Shindo, Eiichiro Yamamoto, Masahiro Kai, Yasushi Sasaki, Takashi Tokino, Hiroshi Nakase and Hiromu Suzuki
- Organizer
  Targeting DNA Methylation and Chromatin for Cancer Therapy
- Data Source
  KAKENHI-PROJECT-15K09456
[Presentation] ヒストンメチル化酵素DOT1Lは多発性骨髄腫の治療標的となりうる2017
- Author(s)
  石黒一也、佐々木基、若杉英樹、北嶋洋志、新沼猛、丸山玲緒、甲斐正広、池田博、石田禎夫、佐々木泰史、時野隆至、仲瀬裕志、鈴木拓
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09456
[Presentation] 多発性骨髄腫に有効なヒストンメチル化阻害薬の探索2016
- Author(s)
  石黒一也，北嶋洋志，新沼　猛，丸山玲緒，甲斐正広，西山廣陽，進藤哲哉，池田　博，石田禎夫，佐々木泰史，時野隆至，仲瀬裕志，鈴木　拓
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市、パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K09456

1. ISHIDA Tadao (20305220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 池田博 (60570132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 丸山玲緒 (60607985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 山本英一郎 (60567915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鈴木拓 (20381254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ishiguro Kazuya 石黒 一也

石黒 一也 イシグロ カズヤ

Research Projects

Research Products

Co-Researchers

大腸癌微小環境における癌線維芽細胞の活性化とCD8陽性T細胞浸潤抑制の病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自然免疫応答に着目した多発性骨髄腫の新規エピジェネティック治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new myeloma therapy targeting DOT1LPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome methylation approach to search mechanisms of malignancy and new therapeutic targets in multiple myeloma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decrease of B-type natriuretic peptide to less than 200 pg/mL predicts longer survival in cardiac immunoglobulin light chain amyloidosis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 多発性骨髄腫においてDOT1L阻害は免疫シグナルを活性化する2022

Author(s)

Organizer

Data Source

[Presentation] DOT1L inhibition activates immunologic signatures in multiple myeloma2022

Author(s)

Organizer

Data Source

[Presentation] Development of a new epigenetic immunotherapy for multiple myeloma2021

Author(s)

Organizer

Data Source

[Presentation] Dual inhibition of EZH2 and G9a suppresses multiple myeloma cell proliferation by affecting interferon signaling2021

Author(s)

Organizer

Data Source

[Presentation] Dual inhibition of EZH2 and G9a suppresses multiple myeloma cell proliferation by affecting interferon signaling2021

Author(s)

Organizer

Data Source

[Presentation] The anti-myeloma effect of dual EZH2 and G9a inhibition2021

Author(s)

Organizer

Data Source

[Presentation] EZH2とG9aの共阻害はインターフェロンシグナルの活性化とIRF-4-MYC axisの抑制により多発性骨髄腫細胞の増殖を抑制する2020

Author(s)

Organizer

Data Source

[Presentation] Development of a new combinational epigenetic treatment for multiple myeloma2020

Author(s)

Organizer

Data Source

[Presentation] 多発性骨髄腫における新規エピジェネティック併用療法の開発2019

Author(s)

Organizer

Data Source

Ishiguro Kazuya 石黒一也

石黒一也イシグロカズヤ