Nii Masafumi 二井理文

Researcher Number	90790832
Other IDs
Affiliation (Current)	2025: 三重大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2023: 三重大学, 医学部附属病院, 講師 2019 – 2022: 三重大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 52040:Radiological sciences-related Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator MRI / タダラフィル / FGR / 脳の発達変容 / 神経学的長期予後 / 脳MRI / 胎児発育不全 / 神経発達指標 / 脳部位別容積 / 子宮動脈血流 … More / 胎盤の酸素化 / 酸素濃度変動 / 胎盤 / 子宮内胎児発育不全 / 2D-Phase contrast法 / 胎盤の酸素濃度変動 / fMRI / 子宮動脈血流量 / 胎盤酸素化 / 2D PC-MRI / BOLD … More Except Principal Investigator 神経損傷 / 胎児心拍モニタリング / 分娩監視 / 胎児心拍細変動 / 胎児発育不全 / 炎症 / 胎児子宮内感染 / 胎児心拍変動 / 自律神経 / 胎児生理学 / 胎児well being / 胎児心拍数モニタリング / 胎児心拍数変動 Less

胎児の脳損傷を予防するための心拍細変動解析による分娩監視指標の開発
- Principal Investigator
  
  真川祥一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Mie University
タダラフィル母体投与が胎児発育不全児の神経学的予後を改善するメカニズムの解明Principal Investigator
- Principal Investigator
  
  二井理文
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Mie University
Evaluation of placental and fetal oxygen concentration in fetal growth restriction by MRI and effect of tadalafil treatmentPrincipal Investigator
- Principal Investigator
  
  Nii Masafumi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Mie University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] CTGエボリューション2021
- Author(s)
  池田智明、山口恭平、二井理文、山口瑞希、田中博明、真川祥一、村林奈緒、真木晋太郎、前田佳紀、三好剛一、桂木真司、古橋芙美、中尾真大、榎本尚助
- Total Pages
  224
- Publisher
  中外医学社
- ISBN
  9784498160187
- Data Source
  KAKENHI-PROJECT-19K17134
[Journal Article] Evaluation of fetal acidemia during delivery using the conventional 5-tier classification and Rainbow systems2024
- Author(s)
  Magawa S, Maki S, Nii M, Yamaguchi M, Tamaishi Y, Enomoto N, Takakura S, Toriyabe K, Kondo E, Ikeda T.
- Journal Title
  
  PLoS ONE
  
  Volume: 18 Issue: 6 Pages: e0287535-e0287535
- DOI
  10.1371/journal.pone.0287535
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09545
[Journal Article] Two-dimensional phase-contrast MRI reveals changes in uterine arterial blood flow in pregnant women administered tadalafil for fetal growth restriction2024
- Author(s)
  Nii Masafumi、Enomoto Naosuke、Ishida Masaki、Magawa Shoichi、Takakura Sho、Maki Shintaro、Tanaka Kayo、Toriyabe Kuniaki、Tanaka Hiroaki、Kondo Eiji、Sakuma Hajime、Ikeda Tomoaki
- Journal Title
  
  Placenta
  
  Volume: 146 Pages: 1-8
- DOI
  10.1016/j.placenta.2023.12.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15896, KAKENHI-PROJECT-22K16877
[Journal Article] Fetal Biometric Assessment and Infant Developmental Prognosis of the Tadalafil Treatment for Fetal Growth Restriction2023
- Author(s)
  Tsuji Makoto、Maki Shintaro、Enomoto Naosuke、Okamoto Kota、Kitamura Asa、Magawa Shoichi、Takakura Sho、Nii Masafumi、Tanaka Kayo、Yodoya Noriko、Tanaka Hiroaki、Sawada Hirofumi、Kondo Eiji、Hirayama Masahiro、Ikeda Tomoaki
- Journal Title
  
  Medicina
  
  Volume: 59 Issue: 5 Pages: 900-900
- DOI
  10.3390/medicina59050900
- Data Source
  KAKENHI-PROJECT-22K16877
[Journal Article] Evaluation of placental oxygenation in fetal growth restriction using blood oxygen level-dependent magnetic resonance imaging.2022
- Author(s)
  Magawa S, Nii M, Enomoto N, Takakura S, Maki S, Tanaka H, Ishida M, Kondo E, Sakuma H, Ikeda T.
- Journal Title
  
  Placenta.
  
  Volume: 126 Pages: 40-45
- DOI
  10.1016/j.placenta.2022.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17134
[Journal Article] Evaluation of placental oxygenation index using blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) during normal late pregnancy.2021
- Author(s)
  Magawa S, Nii M, Ishida M, Takase S, Nakayama R, Enomoto N, Tanaka H, Kondo E, Sakuma H, Ikeda T.
- Journal Title
  
  J Matern Fetal Neonatal Med.
  
  Volume: Jan Issue: 25 Pages: 1-13
- DOI
  10.1080/14767058.2021.1878140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17134
[Journal Article] Tadalafil Treatment Ameliorates Hypoxia and Alters Placental Expression of Proteins Downstream of mTOR Signaling in Fetal Growth Restriction.2020
- Author(s)
  Tsuchiya K, Tanaka K, Tanaka H, Maki S, Enomoto N, Takakura S, Nii M, Toriyabe K, Katsuragi S, Ikeda T.
- Journal Title
  
  Medicina (Kaunas).
  
  Volume: 56(12) Issue: 12 Pages: 722-722
- DOI
  10.3390/medicina56120722
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17134, KAKENHI-PROJECT-19K18638, KAKENHI-PROJECT-19K18694
[Journal Article] Developmental Evaluation of Infants Who Have Received Tadalafil in Utero for Fetal Growth Restriction2020
- Author(s)
  Maki Shintaro、Kato Ineko、Enomoto Naosuke、Takakura Sho、Nii Masafumi、Tanaka Kayo、Tanaka Hiroaki、Hori Shinsuke、Matsuda Kana、Ueda Yukito、Sawada Hirofumi、Hirayama Masahiro、Sudo Akihiro、Ikeda Tomoaki
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 9 Issue: 5 Pages: 1448-1448
- DOI
  10.3390/jcm9051448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09800, KAKENHI-PROJECT-19K17134
[Journal Article] Phase-1 clinical study of tadalafil administered for selective fetal growth restriction in twin pregnancy.2019
- Author(s)
  Magawa S, Nii M, Tanaka H, Furuhashi F, Maki S, Kubo M, Tanaka K, Kondo E, Ikeda T.
- Journal Title
  
  J Matern Fetal Neonatal Med.
  
  Volume: Jun Issue: 7 Pages: 1-8
- DOI
  10.1080/14767058.2019.1624717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17134
[Journal Article] Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy.2019
- Author(s)
  Tanaka H, Maki S, Magawa S, Nii M, Tanaka K, Ikemura K, Toriyabe K, Ikeda T.
- Journal Title
  
  Medicina (Kaunas)
  
  Volume: 55（10） Issue: 10 Pages: 708-708
- DOI
  10.3390/medicina55100708
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17134, KAKENHI-PROJECT-19K18638, KAKENHI-PROJECT-17K08411
[Journal Article] Management of fetal growth restriction using the contraction stress test: a case-control study.2019
- Author(s)
  Tanaka H, Furuhashi FH, Toriyabe K, Matsumoto T, Magawa S, Nii M, Watanabe J, Tanaka K, Umekawa T, Kamimoto Y, Ikeda T.
- Journal Title
  
  J Matern Fetal Neonatal Med.
  
  Volume: 32(19) Issue: 19 Pages: 3221-3225
- DOI
  10.1080/14767058.2018.1461313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17134
[Journal Article] Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial2019
- Author(s)
  Maki Shintaro、Tanaka Hiroaki、Tsuji Makoto、Furuhashi Fumi、Magawa Shoichi、Kaneda Michiko K.、Nii Masafumi、Tanaka Kayo、Kondo Eiji、Tamaru Satoshi、Ogura Toru、Nishimura Yuki、Endoh Masayuki、Kimura Tadashi、Kotani Tomomi、Sekizawa Akihiko、Ikeda Tomoaki
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 8 Issue: 6 Pages: 856-856
- DOI
  10.3390/jcm8060856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09800, KAKENHI-PROJECT-19K17134
[Journal Article] Intrapartum cardiotocogram monitoring between obstetricians and computer analysis.2019
- Author(s)
  Magawa S, Tanaka H, Furuhashi F, Maki S, Nii M, Toriyabe K, Kondo E, Ikeda T.
- Journal Title
  
  J Matern Fetal Neonatal Med
  
  Volume: May Issue: 5 Pages: 1-7
- DOI
  10.1080/14767058.2019.1617688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17134
[Journal Article] Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions.2019
- Author(s)
  Tachibana Ryota, Umekawa Takashi, Yoshikawa Kento, Owa Takao, Magawa Shoichi, Furuhashi Fumi, Tsuji Makoto, Maki Shintaro, Shimada Kyoko, Kaneda K. Michiko, Nii Masafumi, Tanaka Hiroaki, Tanaka Kayo, Kamimoto Yuki, Kondo Eiji, Kato Ineko, Ikemura Kenji, Okuda Masahiro, et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 234-234
- DOI
  10.1038/s41598-018-36084-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08411, KAKENHI-PROJECT-17K08412, KAKENHI-PROJECT-17K09168, KAKENHI-PROJECT-17H04654, KAKENHI-PROJECT-19K08343, KAKENHI-PROJECT-19K09800, KAKENHI-PROJECT-19K17134, KAKENHI-PROJECT-17K16316
[Journal Article] T, Nishimura Y, Endoh M, Kimura T, Kotani T, Sekizawa A, Ikeda T; MIE Study Group. Tadalafil treatment for preeclampsia (medication in preeclampsia; MIE): a multicenter phase II clinical trial.2019
- Author(s)
  Furuhashi F, Tanaka H, Maki S, Tsuji M, Magawa S, Kaneda MK, Nii M, Tanaka K, Ogura T, Nishimura Y, Endoh M, Kimura T, Kotani T, Sekizawa A, Ikeda T
- Journal Title
  
  J Matern Fetal Neonatal Med.
  
  Volume: Nov Issue: 22 Pages: 1-7
- DOI
  10.1080/14767058.2019.1690447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17134
[Journal Article] Cardiac function and tadalafil used for treating fetal growth restriction in pregnant women without cardiovascular disease2018
- Author(s)
  Tanaka Kayo、Tanaka Hiroaki、Maki Shintaro、Kubo Michiko、Nii Masafumi、Magawa Shoichi、Hatano Fumi、Tsuji Makoto、Osato Kazuhiro、Kamimoto Yuki、Umekawa Takashi、Ikeda Tomoaki
- Journal Title
  
  J Matern Fetal Neonatal Med
  
  Volume: 31 Issue: 15 Pages: 1-3
- DOI
  10.1080/14767058.2018.1438401
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16846, KAKENHI-PROJECT-19K17134
[Journal Article] Placental growth factor as a predictor of the efficacy of tadalafil treatment for fetal growth restriction2018
- Author(s)
  Kubo-Kaneda Michiko、Tanaka Hiroaki、Maki Shintaro、Nii Masafumi、Umekawa Takashi、Osato Kazuhiro、Kamimoto Yuki、Kondo Eiji、Ikeda Tomoaki
- Journal Title
  
  The Journal of Maternal-Fetal & Neonatal Medicine
  
  Volume: 26 Issue: 17 Pages: 1-4
- DOI
  10.1080/14767058.2018.1450863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16846, KAKENHI-PROJECT-19K17134
[Presentation] 正常妊娠における分娩時の胎児心拍変動挙動2023
- Author(s)
  真川祥一　真木晋太郎　玉石雄也　榎本尚助　高倉翔　二井理文　鳥谷部邦明　田中博明　近藤英司　池田智明
- Organizer
  母体胎児学会
- Data Source
  KAKENHI-PROJECT-22K09545
[Presentation] 胎児発育不全に対するタダラフィル経母体投与における新生児循環動態の検討2023
- Author(s)
  高倉翔, 真木晋太郎, 加藤麻耶, 玉石雄也, 真川祥一, 二井理文, 田中佳世, 鳥谷部邦明, 田中博明, 池田智明
- Organizer
  第43回日本妊娠高血圧学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16877
[Presentation] タダラフィル投与母体より出生した児の長期予後評価2022
- Author(s)
  真木晋太郎, 高倉翔, 真川祥一, 玉石雄也, 萩元美希, 榎本尚助, 二井理文, 田中佳世, 田中博明, 池田智明
- Organizer
  第58回日本周産期・新生児医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16877
[Presentation] BOLD MRIを用いた,胎児発育不全に対する胎盤酸素化評価2022
- Author(s)
  真川祥一, 二井理文, 榎本尚助, 高倉翔, 真木晋太郎, 田中博明, 池田智昭
- Organizer
  第58回日本周産期・新生児医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16877
[Presentation] タダラフィル投与母体より出生した児の新版K式発達検査を用いた長期発達予後評価2022
- Author(s)
  真木晋太郎, 高倉翔, 玉石雄也, 山口瑞希, 萩元美季, 榎本尚助, 二井理文, 田中佳世, 田中博明, 池田智明
- Organizer
  第74回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K16877
[Presentation] BOLD MRIを用いた,胎児発育不全に対する胎盤酸素化評価2022
- Author(s)
  真川祥一, 二井理文, 榎本尚助, 高倉翔, 真木晋太郎, 田中博明, 池田智昭
- Organizer
  第58回日本周産期・新生児医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] dimensional phase contrast MRIによる子宮動脈血流量評価2021
- Author(s)
  二井理文, 榎本尚助, 真川祥一, 高倉翔, 真木晋太郎, 田中佳世, 鳥谷部邦明, 田中博明, 池田智明
- Organizer
  第57回日本周産期・新生児医学会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] 胎児発育不全に対するタダラフィル経母体投与における、胎児超音波計測値の検2021
- Author(s)
  辻誠, 真木晋太郎, 岡本幸太, 北村亜沙, 高倉翔, 真川祥一, 二井理文, 田中佳世, 田中博明, 桂木真司, 池田智明
- Organizer
  第57回日本周産期・新生児医学会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] FGRに対するタダラフィルの経母体投与における胎児胎盤循環動態の評価2021
- Author(s)
  真木晋太郎, 田中博明, 高倉翔, 榎本尚助, 二井理文, 金城忠嗣, 安藤大史, 菅幸恵, 小谷友美, 遠藤誠之, 関沢明彦, 池田智明
- Organizer
  第57回日本周産期・新生児医学会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] 胎児発育不全に対するタダラフィル治療が胎盤に与える影響　低酸素とmTORシグナリング2021
- Author(s)
  田中佳世, 田中博明, 高倉翔, 真木晋太郎, 二井理文, 池田智明
- Organizer
  第57回日本周産期・新生児医学会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] ヒト胎盤におけるタダラフィルとmTORシグナリングについての検討2021
- Author(s)
  高倉翔, 田中佳世, 榎本尚助, 真木晋太郎, 二井理文, 田中博明, 池田智明
- Organizer
  第41回日本妊娠高血圧学会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] 胎児発育不全に対する胎内でのタダラフィル投与と出生仔の将来の生活習慣病の発症に関する研究2020
- Author(s)
  高倉翔、田中佳世、真木晋太郎、二井理文、鳥谷部邦明、田中博明、池田智明
- Organizer
  第72回日本産科婦人科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] MRIを用いた子宮動脈血流測定の有用性に関する検討2020
- Author(s)
  榎本尚助、二井理文、古橋芙美、高倉翔、真川祥一、真木晋太郎、田中佳世、鳥谷部邦明、田中博明、池田智明
- Organizer
  第72回日本産科婦人科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] タダラフィル内服により子宮動脈血流量は増加する　MRIを用いた検討2020
- Author(s)
  二井理文、榎本尚助、真川祥一、古橋芙美、真木晋太郎、田中佳世、鳥谷部邦明、田中博明、池田智明
- Organizer
  第72回日本産科婦人科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] 子宮内胎児発育不全に対するタダラフィル投与母体から出生した児の発達予後2020
- Author(s)
  真木晋太郎、田中博明、高倉翔、辻誠、古橋芙美、真川祥一、二井理文、鳥谷部邦明、田中佳世、池田智明
- Organizer
  第72回日本産科婦人科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] MRIを用いた胎盤機能および子宮動脈血流評価2019
- Author(s)
  真川祥一, 二井理文, 榎本尚助,石田正樹,中山良平,高瀬伸一,古橋芙美, 真木晋太郎, 田中博明, 佐久間肇, 池田智明
- Organizer
  第7回　新胎児学研究会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] 子宮内胎児発育不全に対するタダラフィル投与母体から出生した児の発達予後2019
- Author(s)
  真木晋太郎, 田中博明, 高倉翔, 古橋芙美, 二井理文, 前田佳紀, 田中佳世, 鳥谷部邦明, 加藤稲子, 池田智明
- Organizer
  第40回　日本妊娠高血圧学会
- Data Source
  KAKENHI-PROJECT-19K17134
[Presentation] 周産期心筋症における心臓MRIを用いた解析2019
- Author(s)
  二井理文, 石田正樹, 高倉翔, 古橋芙美, 真木晋太郎, 前田佳紀, 田中佳世, 鳥谷部邦明, 田中博明, 池田智明
- Organizer
  第40回　日本妊娠高血圧学会
- Data Source
  KAKENHI-PROJECT-19K17134

1. 真川祥一 (40812300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 松田直 (50361100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 池田智明 (80202894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 真木晋太郎 (90794371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. UMEKAWA TAKASHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. TANAKA HIROAKI

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. TANAKA KAYO

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
8. IKEMURA Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 奥田真弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 久保倫子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nii Masafumi 二井 理文

Research Projects

Research Products

Co-Researchers

胎児の脳損傷を予防するための心拍細変動解析による分娩監視指標の開発

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Project Period (FY)

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タダラフィル母体投与が胎児発育不全児の神経学的予後を改善するメカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of placental and fetal oxygen concentration in fetal growth restriction by MRI and effect of tadalafil treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] CTGエボリューション2021

Author(s)

Total Pages

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Data Source

[Journal Article] Evaluation of fetal acidemia during delivery using the conventional 5-tier classification and Rainbow systems2024

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[Journal Article] Two-dimensional phase-contrast MRI reveals changes in uterine arterial blood flow in pregnant women administered tadalafil for fetal growth restriction2024

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[Journal Article] Fetal Biometric Assessment and Infant Developmental Prognosis of the Tadalafil Treatment for Fetal Growth Restriction2023

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[Journal Article] Evaluation of placental oxygenation in fetal growth restriction using blood oxygen level-dependent magnetic resonance imaging.2022

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[Journal Article] Evaluation of placental oxygenation index using blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) during normal late pregnancy.2021

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[Journal Article] Tadalafil Treatment Ameliorates Hypoxia and Alters Placental Expression of Proteins Downstream of mTOR Signaling in Fetal Growth Restriction.2020

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[Journal Article] Developmental Evaluation of Infants Who Have Received Tadalafil in Utero for Fetal Growth Restriction2020

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[Journal Article] Phase-1 clinical study of tadalafil administered for selective fetal growth restriction in twin pregnancy.2019

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[Journal Article] Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy.2019

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[Journal Article] Management of fetal growth restriction using the contraction stress test: a case-control study.2019

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[Journal Article] Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial2019

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Nii Masafumi 二井理文

[Presentation] 胎児発育不全に対するタダラフィル治療が胎盤に与える影響　低酸素とmTORシグナリング2021