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Kawaguchi Yoshimasa  川口 祥正

ORCIDConnect your ORCID iD *help
Researcher Number 90936808
Affiliation (Current) 2025: 京都大学, 化学研究所, 助教
Affiliation (based on the past Project Information) *help 2022 – 2025: 京都大学, 化学研究所, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Transformative Research Areas, Section (II)
Except Principal Investigator
Broad Section E / Transformative Research Areas, Section (II)
Keywords
Principal Investigator
ペプチド / 細胞内送達 / ターゲティング / 細胞質送達ペプチド / in vivo / 細胞内取込み / タンパク質 / 高分子送達 / 細胞内導入ペプチド / エンドソーム脱出 … More / エンドサイトーシス / コンジュゲート / 膜傷害性ペプチド / 細胞質 / 抗体 / 脂質パッキング / 細胞膜 / 膜透過 / 核酸 … More
Except Principal Investigator
ペプチド / 細胞膜透過 / 細胞機能制御 / 細胞膜透過性 / 液滴 / 細胞内送達 / 抗体 / 核酸医薬 / 分子マシン / 中分子医薬 / オリゴ核酸 / 膜モジュレータ Less
  • Research Projects

    (4 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (6 People)
  •  細胞膜をゆらす核酸医薬の膜透過機構の総合理解と膜透過学の創成

    • Principal Investigator
      大澤 昂志
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      The University of Osaka
  •  Direct Membrane Penetration of Nucleic Acid Pharmaceuticals Utilizing Membrane Modulator and Elucidation of its MechanismPrincipal Investigator

    • Principal Investigator
      川口 祥正
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Kyoto University
  •  Understanding the molecular and cellular basis and controlling cellular phenomena: A New Concept for Intracellular Delivery of Antibodies

    • Principal Investigator
      二木 史朗
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section E
    • Research Institution
      Kyoto University
  •  Novel innovations in cytoplasmic delivery peptides directed at intracellular delivery of antibodiesPrincipal Investigator

    • Principal Investigator
      Kawaguchi Yoshimasa
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Kyoto University

All 2024 2023 2022

All Journal Article Presentation Patent

  • [Journal Article] E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery2024

    • Author(s)
      Kawaguchi Yoshimasa、Kawamura Yuki、Hirose Hisaaki、Kiyokawa Megumi、Hirate Momo、Hirata Tsuyoshi、Higuchi Yuriko、Futaki Shiroh
    • Journal Title

      Journal of Controlled Release

      Volume: 367 Pages: 877-891

    • DOI

      10.1016/j.jconrel.2024.01.067

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Journal Article] Liquid Droplet-Mediated Formulation of Lipid Nanoparticles Encapsulating Immunoglobulin G for Cytosolic Delivery2024

    • Author(s)
      Hirai Yusuke、Kawaguchi Yoshimasa、Kasahara Chisato、Hirose Hisaaki、Futaki Shiroh
    • Journal Title

      Molecular Pharmaceutics

      Volume: 21 Issue: 4 Pages: 1653-1661

    • DOI

      10.1021/acs.molpharmaceut.3c00868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Patent] 脂質ナノ粒子、医薬組成物、および脂質ナノ粒子の製造方法2024

    • Inventor(s)
      二木史朗 、平井勇祐 、川口祥正、広瀬久昭、笠原千聖
    • Industrial Property Rights Holder
      二木史朗 、平井勇祐 、川口祥正、広瀬久昭、笠原千聖
    • Industrial Property Rights Type
      特許
    • Filing Date
      2024
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Patent] 薬物送達組成物2023

    • Inventor(s)
      二木史朗、平井勇祐、広瀬久昭、川口祥正
    • Industrial Property Rights Holder
      二木史朗、平井勇祐、広瀬久昭、川口祥正
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-031510
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Patent] 細胞質送達ペプチド2023

    • Inventor(s)
      川口祥正、二木史朗
    • Industrial Property Rights Holder
      川口祥正、二木史朗
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-174558
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] 低毒性かつ高効率な新規高分子細胞質送達ペプチドの創製2024

    • Author(s)
      川口 祥正、川村 優貴、清川 めぐみ、広瀬 久昭、樋口 ゆり子、二木 史朗
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] 抗体の細胞質送達に向けた抗体ーL17ER4コンジュゲートの創製2024

    • Author(s)
      寺田 旺之、川口 祥正、二木 史朗
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] Development of an Efficient Endosomolytic Peptide for Intracellular Protein Delivery2023

    • Author(s)
      Yoshimasa Kawaguchi, Shiroh Futaki
    • Organizer
      13th Austrian Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] Development of cytosolic delivery peptides by attenuated membrane lytic activity2023

    • Author(s)
      Yoshimasa Kawaguchi, Shiroh Futaki
    • Organizer
      第61回日本生物物理学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] Development of a Novel Endosomolytic Peptide for Cytosolic Delivery of Proteins2023

    • Author(s)
      Yoshimasa Kawaguchi
    • Organizer
      Satellite Symposium of the 60th Japanese Peptide Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] Elucidation of the Cellular Delivery Mechanism of Melittin Derivatives2023

    • Author(s)
      Yusuke Uehata, Yoshimasa Kawaguchi, Naoki Tamemoto, Shiroh Futaki
    • Organizer
      The 60th Japanese Peptide Symposium
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] Development of a Novel Cytosolic Delivery Peptide with Attenuated Cytotoxicity and Enhanced Endosomal Uptake2023

    • Author(s)
      Yoshimasa Kawaguchi, Shiroh Futaki
    • Organizer
      13th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] DEVELOPMENT OF MELITTIN DELIVATIVES FOR INTRACELLULAR DELIVERY OF BIOMACROMOLECULES2022

    • Author(s)
      Yoshimasa Kawaguchi, Naoki Tamemoto, Masataka Fumoto, Shiroh Futaki
    • Organizer
      第59回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-22K15250
  • [Presentation] 生理活性物質の細胞内送達に向けたMelittin誘導体の創製2022

    • Author(s)
      川口祥正、為本尚樹、麓昌高、二木史朗
    • Organizer
      第43回生体膜と薬物の相互作用シンポジウム
    • Data Source
      KAKENHI-PROJECT-22K15250
  • 1.  大澤 昂志 (00783226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  三木 康嗣 (60422979)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  篠田 渉 (70357193)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  二木 史朗 (50199402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  伊藤 貴浩 (00323452)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  樋口 ゆり子 (40402797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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