OGUMA Keiji 小熊恵二

… Alternative Names

小熊惠ニオグマケイジ

小熊恵二オグマケイジ

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Researcher Number	00002262
Other IDs
Affiliation (based on the past Project Information) *help	2012 – 2013: 岡山大学, 大学院・医歯薬学総合研究科, 教授 2011 – 2012: 岡山大学, 医歯(薬)学総合研究科, 教授 2005 – 2010: 岡山大学, 大学院・医歯薬学総合研究科, 教授 2009: 岡山大, 医歯(薬)学総合研究科, 教授 2006 – 2007: 岡山大学, 大学院・医歯薬総合研究科, 教授 … More 2006: Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 2001 – 2003: Graduate School of Medicine and Dentistry, Okayama University, Professor, 大学院・医歯学総合研究科, 教授 2002: Okayama University Graduate School of Dentistry and Medicine, Department of Bacteriology, Professor, 大学院・歯学総合研究科, 教授 2001: Okayama University, Graduate School of Medicine and Dentistry, Professor, 医歯学総合研究科, 教授 1993 – 2000: 岡山大学, 医学部, 教授 1989: 札幌医科大学, 医学部, 教授 1986: Sapporo Medical College, Chief Professor, 医学部, 教授 Less
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / 細菌学 Except Principal Investigator Bacteriology (including Mycology) / Prosthetic dentistry / Bacteriology (including Mycology) / Pathological medical chemistry / 補綴理工系歯学
Keywords	Principal Investigator ボツリヌス毒素 / ボツリヌス菌 / Hemagglutinin / Botulinum toxin / 赤血球凝集素 / Receptor / Clostridium botulinum / 毒素遺伝子 / Neurotoxin / Siglec family … More / β-trefoil domain / Binding / Progenitor toxin / シアル酸 / レセプター / Botulism / ELISA / ボツリヌス中毒 / 食品 / 医療・福祉 / 蛋白質 / 感染症 / 細菌 / Phage / 遺伝子 / プラスミド / ファージ / ボッリヌス菌 / food / medicine, welfare / protein / infectious disease / bacteria / Botulinum Toxin / Sialic acid / Lactose / Hemaggultinin / Hemag glutinin / Neuro toxin / Monoclonal antibody / Ga1β1-4 G1cNac / Sialy lactose / Salic acid / Haemagglutinin / ムチン蛋白質 / モノクローナル抗体 / Galβ1-4GlcNAc / シアリルラクトース / sialic acid / receptor / nontoxic component / botulinum toxin / C.botulinum / ポツリヌス毒素 / ポツリヌス菌 / 無毒成分 / Toxin gene / Serum therapy / Vaccine / 血清療法 / ワクチン / 構造・生理 / 診断 / 分類 / 遺伝 / 疫学 / 感染免疫 / 病原性 / スーパー抗原 / 内毒素 / 外毒素 / 細菌感染 / 細菌毒素 / ケミカルメディエーター / ATP / 初代神経細胞 / NG-108細胞 / C_3酵素 / 神経伝達物質 / 乳児ボツリヌス症 / ブチリカム菌 / クロ-ニング … More Except Principal Investigator Helicobacter pylori / ボツリヌス毒素 / HSP60 / DEC205 / TLR / MAPK / 動脈硬化 / Heat shock protein / マクロファージ / 神経細胞 / 神経内走行 / 改良A型ボツリヌス毒素 / 遊離 / 神経節細胞 / macrophage / Atherosclerosis-prone mouse / Immune response / Atherosclerosis / 高脂血症モデルマウス / H.pylori / 動脈硬化好発モデルマウス / 免疫応答 / H. pylori / Mucosal immunit / DNA microarray / T helper 1 and 2 (Th-1 and -2) / Mucosa-associated lympho tissue (MALT) / Helicobacter phlori / CD40L / Th-1 and Th-2 / IgGサブクラス / ヘリコバクターピロリ / MALTリンパ腫 / 粘膜免疫 / DNAチップ / heat shock protein / T helper 1 and 2 / neutralization / perfusion culture / hybridoma / tetanus anti-toxin / human monoclonal antibody / 抗毒素 / ジフテリア / ボツリヌス中毒症 / ハイブリドーマ / 連続培養 / ヒト型モノクローナル抗体 / 破傷風 / PHICTX phage / virulence plasmid / Vibrio genome / Ipa protein / hemolysin / motility / collagenase / Two component regulatory system / ヘリコバクター・ピロリ / B.fragilis / 腸炎ビブリオ / P.gingivalis / 赤痢菌Ipa蛋白 / 緑膿菌 / 病原細菌 / φCTXファージ / ビルレンスプラスミド / ビブリオゲノム / Ipaタンパク / 溶血毒 / 運動性 / コラゲナーゼ / 2成分制御系 / Treatment / Diagnosis / Pathogenesis / Epidemiology / EHEC O157 / Escherichia coli / 迅速診断 / 治療・予防 / 病原性 / 疫学調査 / O157 / 腸管出血性大腸菌 / 三叉神経 / 海馬 / トレハロース / 長寿命化 / 活性 / 神経筋細胞 / Ａ型ボツリヌス毒素 / A型ボツリヌス毒素 / 知覚神経節 / 疼痛行動 / 三叉神経障害性疼痛モデル / CagA / HSP / Macrophage / Helicobacter / 冠動脈疾患 / 2 / Th1 / 胃ガン / 神経ペプチド / 小胞 / 神経痛 / 取り込み / 改良型ボツリヌス毒素 / 神経小胞 / 神経伝達物質 / 三叉神経痛 Less

Development of neuro-regeneration with Botulinum toxin
- Principal Investigator
  
  MATSUKA Yoshizo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthetic dentistry
- Research Institution
  The University of Tokushima
  Okayama University
Development of a new treatment for trigeminal neuron sensitization
- Principal Investigator
  
  MATSUKA Yoshizo
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  The University of Tokushima
  Okayama University
各種ボツリヌス毒素の腸管よりの吸収機構の解明とその応用Principal Investigator
- Principal Investigator
  
  小熊惠二
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Role of macrophage in Helicobacter pylori infection
- Principal Investigator
  
  YOKOTA Kenji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Establishment of new procedure for botulism including bioterrorism, and application of botulinum toxin to the treatmentPrincipal Investigator
- Principal Investigator
  
  OGUMA Keiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Basic mechanisms of nociceptive sensitization of first order sensory neuron in trigeminal neuralgia and treatment development
- Principal Investigator
  
  MATSUKA Yoshizo (MATUKA Yoshizo)
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Okayama University
Pathobiochemical and immunological study on infection-accelerated atherosclerosis and its regulation.
- Principal Investigator
  
  MATSUURA Eiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Okayama University
Roles of Monocytes/Macrophage for Acquired Immunity in Helicobacter pylori Infection
- Principal Investigator
  
  YOKOTA Kenji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Establishment of new procedures for botulism including bio-terrorism and for the treatment of patients with dystonia.Principal Investigator
- Principal Investigator
  
  OGUMA Keiji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  OKAYAMA UNIVERSITY
Analysis of tertial structure and function of non-toxic components associating with Clostridium botulinum neurotoxins.Principal Investigator
- Principal Investigator
  
  OGUMA Keiji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  OKAYAMA UNIVERSITY
Analysis of absorption of Clostridium botulinum toxins from the small infestinePrincipal Investigator
- Principal Investigator
  
  OGUMA Keiji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Roles of HSP60 in Helicobacter pylori infection
- Principal Investigator
  
  YOKOTA Kenji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Establishment of a mass production system of human monoclonal anti-toxin antibodies
- Principal Investigator
  
  SUGIMOTO Nakaba
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
細菌感染症発症機構の分子生物学的手法による解析とその治療への応用Principal Investigator
- Principal Investigator
  
  小熊惠二
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Analysis of absorption of Clostridium botulinum neurotoxin-nontoxic component complex from the small intestine.Principal Investigator
- Principal Investigator
  
  OGUMA Keiji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Research on enterohaemorrhagic E.coli (EHEC) including its epidemiology, pathogenesis, and development of diagnosis and treatment..
- Principal Investigator
  
  HONDA Takeshi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Institution
  Osaka University
Studies on molecular genetics of bacterial pathogenesis
- Principal Investigator
  
  NAKAZAWA Teruko
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Yamaguchi University
Structure and function of the nontoxic components of Clostridium botulinum progenitor toxins.Principal Investigator
- Principal Investigator
  
  OGUMA Keiji
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
ボツリヌス毒素の作用機構の解明Principal Investigator
- Principal Investigator
  
  小熊惠二
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Prevention of cattle-botulism in AustraliaPrincipal Investigator
- Principal Investigator
  
  OGUMA Keiji, 小熊恵二
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Okayama University, Medical School
ボツリヌス毒素の構造と機能の分子生物学的解析Principal Investigator
- Principal Investigator
  
  小熊恵二
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
ボツリヌス毒素産生遺伝子に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  小熊恵二
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Sapporo Medical University
Studies on phage nucleic acid relating to toxin production of Clostridium botulinum types C and D.Principal Investigator
- Principal Investigator
  
  OGUMA Keiji
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Sapporo Medical College

All 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

[Book] 臨床と微生物(Vol.135 No.4)2008
- Author(s)
  小熊惠二
- Publisher
  近代出版
- Data Source
  KAKENHI-PROJECT-19390126
[Book] 臨床と微生物Vol. 135 No. 42008
- Author(s)
  小熊恵二
- Publisher
  近代出版
- Data Source
  KAKENHI-PROJECT-19390126
[Book] 構造生物学-ポストゲノム時代のタンパク質研究- 2.7 各種不随意運動の治療に用いられている最強の毒素 ; ボツリヌス毒素2007
- Author(s)
  小熊惠二
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-19390126
[Book] 構造生物学-ポストゲノム時代のタンパク質研究-2.7各種不随意運動の治療に用いられている最強の毒素;ボツリヌス毒素.2007
- Author(s)
  小熊惠二
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-19390126
[Book] 遺伝(別冊)科学は食のリスクをどこまで減らせるか第5章「病原細菌-毒素と食中毒」2006
- Author(s)
  小熊恵二, 他
- Publisher
  NTS
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390127
[Book] 医学のあゆみ「ボツリヌス神経毒素製剤の臨床応用」2006
- Author(s)
  小熊恵二, 他
- Publisher
  医歯薬出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390127
[Book] ハリソン内科学第2版(破傷風,ボツリヌス中毒,ガス壊疽,その他のClostridium感染症)2006
- Author(s)
  小熊惠二
- Publisher
  メディカル・サイエンス・インターナショナル
- Data Source
  KAKENHI-PROJECT-17390127
[Book] 直伝(別冊)「科学は食のリスクをどこまで減らせるか」第5章「病原細菌」-毒素と食中毒2006
- Author(s)
  小熊恵二, 武士甲一, 中野宏幸
- Publisher
  NTS
- Data Source
  KAKENHI-PROJECT-17390127
[Book] 日本医事新報No.4212.「ボツリヌス菌感染症と免疫」2005
- Author(s)
  小熊恵二
- Publisher
  日本医事新報社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390127
[Journal Article] Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay2012
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Maruhama K, Yamamoto Y, Neubert JK, Noland TA, Watanabe K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- Journal Title
  
  Journal of Oral Rehabilitation
  
  Volume: 39 Issue: 1 Pages: 63-72
- DOI
  10.1111/j.1365-2842.2011.02236.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390365, KAKENHI-PROJECT-22500427, KAKENHI-PROJECT-23659897
[Journal Article] Application of purified botulinum type A neurotoxin to treat experimental trigeminal neuropathy in rats and patients with urinary incontinence and prostatic hyperplasia2012
- Author(s)
  Matsuka Y, Yokoyama T, Yamamoto Y, Suzuki T, Nishikawa A, Ohyama T, Watanabe T, Kuboki T, Nagai A, Oguma K.
- Journal Title
  
  Journal of Toxicology
  
  Volume: (online journal) Pages: 648384-648384
- DOI
  10.1155/2012/648384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390365, KAKENHI-PROJECT-22500427, KAKENHI-PROJECT-23659897
[Journal Article] Peripheral administration of botulinum toxin type A neurotoxin reverses trigeminal neuropathic pain symptoms2011
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Kuboki T, Oguma K.
- URL
  http://posters.f1000.com/PosterList?posterID=763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390365
[Journal Article] The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori.2011
- Author(s)
  Take S, Mizuno M, Ishiki K, Yoshida T, Ohara N, Yokota K, Oguma K, Okada H, Yamamoto K
- Journal Title
  
  J Gastroenterol.
  
  Volume: 46 Pages: 318-324
- NAID
  10029027739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Peripheral administration of botulinum toxin type A neurotoxin reverses trigeminal neuropathic pain symptoms2011
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Kuboki T, Oguma K
- Journal Title
  
  http://posters.f1000.com/PosterList?posterID=763
- Data Source
  KAKENHI-PROJECT-22390365
[Journal Article] Induction of antibacterial activity in larvae of the blowfly Lucilia sericata by an infected environment.2010
- Author(s)
  Kawabata T, Mitsui H, Yokota K, Ishino K, Oguma K, Sano S.
- Journal Title
  
  Med Vet Entomol.
  
  Volume: 24 Pages: 375-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Induction of antibacterial activity in larvae of the blowfly Lucilia sericata by an infected environment.2010
- Author(s)
  Kawabata T, Mitsui H, Yokota K, Ishino K, Oguma K, Sano S.
- Journal Title
  
  Med Vet Entomol. 24(4)
  
  Pages: 375-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Peripheral administration of Botulinum toxin type A decreases exaggerated neurotransmitter release and reverses neuropathy-induced gene expression changes in trigeminal ganglia2010
- Author(s)
  Kumada A, Matsuka Y, Kitamura Y, Spigelman I, Ishihara Y, Yamamoto Y, Hikasa T, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Journal Title
  
  http://posters.f1000.com/Conferences?confID=3&sect ID=null&posterID=266.12
- Data Source
  KAKENHI-PROJECT-22390365
[Journal Article] Passive oral immunization by egg yolk immunoglobulin (IgY) to Vibrio cholerae effectively prevents cholera.2010
- Author(s)
  Hirai K, Arimitsu H, Umeda K, Yokota K, Shen L, Ayada K, Kodama Y, Tsuji T, Hirai Y, Oguma K.
- Journal Title
  
  Acta Med Okayama. 64(3)
  
  Pages: 163-170
- NAID
  120002311046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Peripheral administration of Botulinum toxin type A decreases exaggerated neurotransmitter release and reverses neuropathy-induced gene expression changes in trigeminal ganglia2010
- Author(s)
  Kumada A, Matsuka Y, Kitamura Y, Spigelman I, Ishihara Y, Yamamoto Y, Hikasa T, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- URL
  http://posters.f1000.com/Conferences?confID=3&sectID=null&posterID=266.12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390365
[Journal Article] Behcet's disease (Adamantiades-Behcet's disease).2010
- Author(s)
  Kaneko F, Togashi A, Saito S, Sakuma H, Oyama N, Nakamura K, Yokota K, Oguma K.
- Journal Title
  
  Clin Dev Immunol. 2011 Review.
  
  Pages: 681956-681956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Passive oral immunization by egg yolk immunoglobulin (IgY) to Vibrio cholerae effectively prevents cholera.2010
- Author(s)
  Hirai K, Arimitsu H, Umeda K, Yokota K, Shen L, Ayada K, Kodama Y, Tsuji T, Hirai Y, Oguma K.
- Journal Title
  
  Acta Med Okayama.
  
  Volume: 64 Pages: 163-170
- NAID
  120002311046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori.2010
- Author(s)
  Take S, Mizuno M, Ishiki K, Yoshida T, Ohara N, Yokota K, Oguma K, Okada H, Yamamoto K.
- Journal Title
  
  J Gastroenterol. 46(3)
  
  Pages: 318-324
- NAID
  10029027739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Crystal structure of the HA3 subcomponent of Clostridium botulinum type C progenitor toxin2009
- Author(s)
  Nakamura T, Kotani M, Tonozuka T, Ide A, Oguma K, Nishikawa A
- Journal Title
  
  J Mol Biol. 385
  
  Pages: 1193-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Botulinum toxin type A (150 kDa) decreases exaggerated neurotransmitter release from trigerminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction2009
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama W, Kuboki T, and Oguma K
- Journal Title
  
  Neuroscience 159
  
  Pages: 1422-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Helicobacter pylori heat shock protein 60 antibodies are associated with gastric cancer.2009
- Author(s)
  Tanaka A, Kamada T, Yokota K, Shiotani A, Hata J, Oguma K, Haruma K.
- Journal Title
  
  Pathol Res Pract. 205(10)
  
  Pages: 690-694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Helicobacter pylori heat shock protein 60 antibodies are associated with gastric cancer.2009
- Author(s)
  Tanaka A, Kamada T, Yokota K, Shiotani A, Hata J, Oguma K, Haruma K.
- Journal Title
  
  Pathol Res Pract 205
  
  Pages: 609-614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Anabolic utilization of steroid hormones in Helicobacter pylori.2009
- Author(s)
  Hosoda K, Shimomura H, Hayashi S, Yokota K, Oguma K, Hirai Y.
- Journal Title
  
  FEMS Microbiol Lett. 297(2)
  
  Pages: 173-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori.2009
- Author(s)
  Shimomura H, Hosoda K, Hayashi S, Yokota K, Oguma K, Hirai Y
- Journal Title
  
  FEMS Microbiol Lett 301
  
  Pages: 84-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Helicobacter pylori eradication may induce de novo, but transient and mild, reflux esophagitis : Prospective endoscopic evaluation.2009
- Author(s)
  Take S, Mizuno M, Ishiki K, Nagahara Y, Yoshida T, Yokota K, Oguma K, Okada H, Yamamoto K.
- Journal Title
  
  J Gastroenterol Hepatol 24
  
  Pages: 107-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] 三叉神経痛治療のための薬物治療法の開発2009
- Author(s)
  松香芳三, 北村洋一, 山本由弥子, 園山亘, I.Spigelman, 小熊恵二, 窪木拓男
- Journal Title
  
  日本歯科医学会誌 28
  
  Pages: 49-53
- NAID
  10025692891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease.2009
- Author(s)
  Hamada T, Yokota K, Ayada K, Hirai K, Kamada T, Haruma K, Chayama K, Oguma K.
- Journal Title
  
  Helicobacter. 14(6)
  
  Pages: 545-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis.2009
- Author(s)
  Ayada K, Yokota K, Hirai K, Fujimoto K, Kobayashi K, Ogawa H, Hatanaka K, Hirohata S, Yoshino T, Shoenfeld Y, Matsuura E, Oguma K.
- Journal Title
  
  Lupus. 18(13)
  
  Pages: 1154-1168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Helicobacter pylori eradication may induce de novo, but transient and mild, reflux esophagitis : Prospective endoscopic evaluation.2009
- Author(s)
  Take S, Mizuno M, Ishiki K, Nagahara Y, Yoshida T, Yokota K, Oguma K, Okada H, Yamamoto K.
- Journal Title
  
  J Gastroenterol Hepatol. 24(1)
  
  Pages: 107-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori.2009
- Author(s)
  Shimomura H, Hosoda K, Hayashi S, Yokota K, Oguma K, Hirai Y.
- Journal Title
  
  FEMS Microbiol Lett. 301(1)
  
  Pages: 84-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Botulinum toxin type A (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction2009
- Author(s)
  Kitamura Y、Matsuka Y、Spigelman I、Ishihara Y、Yamamoto Y、Sonoyama W、Kamioka H、Yamashiro T、Kuboki T、Oguma K
- Journal Title
  
  Neurosceince Vol.159
  
  Pages: 1422-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Chronic infections and atherosclerosis.2009
- Author(s)
  Ayada K, Yokota K, Kobayashi K, Shoenfeld Y, Matsuura E, Oguma K.
- Journal Title
  
  Clin Rev Allergy Immunol. 37(1) Review.
  
  Pages: 44-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Immune reactions against elongation factor 2 kinase : specific pathogenesis of gastric ulcer from Helicobacter pylori infection.2009
- Author(s)
  Ayada K, Yokota K, Kawahara Y, Yamamoto Y, Hirai K, Inaba T, Kita M, Okada H, Yamamoto K, Oguma K.
- Journal Title
  
  Clin Dev Immunol 2009
  
  Pages: 623-633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Botulinum toxin type A(150 kDa)decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction2009
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Journal Title
  
  Neuroscience 259
  
  Pages: 1422-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Chronic infections and atherosclerosis.2009
- Author(s)
  Ayada K, Yokota K, Kobayashi K, Shoenfeld Y, Matsuura E, Oguma K.
- Journal Title
  
  Clin Rev Allergy Immunol 37
  
  Pages: 44-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] 三叉神経痛治療のための薬物治療法の開発2009
- Author(s)
  松香芳三、北村洋一、山本由弥子、園山亘、Spigelman Y、小熊恵二、窪木拓男
- Journal Title
  
  日本歯科医学会誌 28巻
  
  Pages: 49-53
- NAID
  10025692891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Immune reactions against elongation factor 2 kinase : specific pathogenesis of gastric ulcer from Helicobacter pylori infection.2009
- Author(s)
  Ayada K, Yokota K, Kawahara Y, Yamamoto Y, Hirai K, Inaba T, Kita M, Okada H, Yamamoto K, Oguma K.
- Journal Title
  
  Clin Dev Immunol. 2009
  
  Pages: 850623-850623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Anabolic utilization of steroid hormones in Helicobacter pylori.2009
- Author(s)
  Hosoda K, Shimomura H, Hayashi S, Yokota K, Oguma K, Hirai Y.
- Journal Title
  
  FEMS Microbiol Lett. 297
  
  Pages: 179-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease.2009
- Author(s)
  Hamada T, Yokota K, Ayada K, Hirai K, Kamada T, Haruma K, Chayama K, Oguma K.
- Journal Title
  
  Helicobacter 14
  
  Pages: 545-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Botulinum toxin type A (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction.2009
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- Journal Title
  
  Neurosceince 159
  
  Pages: 1422-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] 三叉神経痛治療のための薬物治療法の開発2008
- Author(s)
  松香芳三, 北村洋一, 山本由弥子, 園山亘, I. Spigelman, 小熊恵二, 窪木拓男
- Journal Title
  
  日本歯科医学会誌 28
  
  Pages: 49-53
- NAID
  10025692891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] The effect of peripheral administration of botulinum toxin type A in neuropathic pain rats2008
- Author(s)
  Matsuka Y、Kitamura Y、Spigelman I、Akther R、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Journal Title
  
  Toxicon Vol.51
  
  Pages: 7-7
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Molecular properties of each subcomponent in Clostridium botulinum type B haemagglutinin complex2008
- Author(s)
  Arimitsu H, Sakaguchi Y, Lee JC, Ochi S, Tsukamoto K, Yamamoto Y, Ma S, Tsuji T, and Oguma K
- Journal Title
  
  Microb Pathog. 45
  
  Pages: 142-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] The role of streptococcal hypersensitivity in the pathogenesis of Behcet's Disease.2008
- Author(s)
  Kaneko F, Oyama N, Yanagihori H, Isogai E, Yokota K, Oguma K.
- Journal Title
  
  Eur J Dermatol. 18(5)
  
  Pages: 489-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590445
[Journal Article] Botulinum toxin blocks neurotransmitter release from somata of rat neuropathic trigeminal ganglion neurons2008
- Author(s)
  itamura Y、Matsuka Y、Ishihara Y、Spigelman I、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Journal Title
  
  Toxicon Vol.51
  
  Pages: 6-6
- Data Source
  KAKENHI-PROJECT-18390512
[Journal Article] Sugar-binding sites of the HA1 subcomponent of Clostridium botulinum type C progenitor toxin2008
- Author(s)
  Nakamura T, Tonozuka T, Idea A, Yuzawa T, Oguma K and Nishikawa A
- Journal Title
  
  J. Mol Biol. 376
  
  Pages: 854-867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption2008
- Author(s)
  Matsumura T, Jin Y, Kabumoto Y, Takegahara Y, Oguma K, Lencer WI, and Fujinaga Y
- Journal Title
  
  Cell Microbiol. 10
  
  Pages: 355-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Cterminal half fragment (50 kDa) of heavy chain components of Clostridium botulinum type C and D neurotoxins can be used as an effective vaccine2007
- Author(s)
  Lee JC, Hwang HJ, Sakaguchi Y, Yamamoto Y, Arimitsu H, Tsuji T, Watanabe T, Ohyama T, Tsuchiya T, and Oguma K
- Journal Title
  
  Microbiol. Immunol 51
  
  Pages: 445-455
- NAID
  10020280881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Identification of structural genes for Clostridium botulinum type C neurotoxin-converting phage particles2007
- Author(s)
  Hwang HJ, Lee JC, Yamamoto Y, Sarker MR, Tsuchiya T, Oguma K
- Journal Title
  
  FEMS Microbiol. Lett. 270
  
  Pages: 82-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Conversion of flavodoxin from holoenzyme to apoprotein during growth phase changes in Helicobacter pylori2007
- Author(s)
  Shimomura, H., Hayashi, S., Yokota, K., Oguma, K., Hirai, Y
- Journal Title
  
  J Bacteriol 189
  
  Pages: 4960-4963
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Baseline gastric mucosal atrophy is a risk factor associated with the development of gastric cancer after Helicobacter pylori eradication therapy in patients with peptic ulcer diseases.2007
- Author(s)
  Take S, Mizuno M, Ishiki K, Nagahara Y, Yoshida T, Yokota K, Oguma K.
- Journal Title
  
  J Gastroenterol. 42
  
  Pages: 21-27
- NAID
  10018539759
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Human milk SIgA binds to botulinum type B 16S toxin and limits toxin adherence on T84 cells2007
- Author(s)
  Matsumura T, Fujinaga Y, Jin Y, Kabumoto Y, Oguma K
- Journal Title
  
  Biochem. Biophysic Res. Communi. 352
  
  Pages: 867-872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes2007
- Author(s)
  Zhao Y, Yokota K, Ayada K, Yamamoto Y, Okada T, Shen L, Oguma K.
- Journal Title
  
  J Med Microbiol. 56
  
  Pages: 154-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Chronic infections and atherosclerosis2007
- Author(s)
  Ayada, K., Yokota, K., Kobayashi, K., Shoenfeld, Y., Matsuura, E., Oguma, K
- Journal Title
  
  Ann N Y Acad Sof 1108
  
  Pages: 594-602
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Baseline gastric mucosal atrophy is a risk factor associated with the development of gastric cancer after Helicobacter pylori eradication therapy in patients with peptic ulcer diseases2007
- Author(s)
  Take S, Mizuno M, Ishiki K, Nagahara Y, Yoshida T, Yokota K, Oguma K
- Journal Title
  
  J Gastroebterol. 42
  
  Pages: 21-27
- NAID
  10018539759
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Antibodies against heat shock protein 60 derived from Helicobacter pylori diagnostic implications in cardiovascular disease2007
- Author(s)
  Okada, T., Ayada, K., Usui, S., Yokota, K., Cui, J., Kawahara, Y., Inaba, T., Hirohata, S., Mizuno, M., Yamamoto, D., Kusachi, S., Matsuura, E., Oguma, K
- Journal Title
  
  J Autoimmun 29
  
  Pages: 106-115
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Effect of nicking the C-terminal region of the Clostridium botulinum serotype D neurotoxin heavy chain on its toxicity and molecular properties2007
- Author(s)
  Suzuki T, Kouguchi H, Watanabe T, Hasegawa K, Yoneyama T, Niwa K, Nishikawa A, Lee JC, Oguma K, Ohyama T
- Journal Title
  
  Protein J. 26
  
  Pages: 173-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Conversion of flavodoxin from holoenzyme to apoprotein during growth phase changes in Helicobacter pylori2007
- Author(s)
  Shimomura H, Hayashi S, Yokota K, Oguma K, Hirai Y.
- Journal Title
  
  J Bacteriol. 189
  
  Pages: 4960-4963
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Baseline gastric mucosal atrophy is a risk factor associated with the development of gastric Cancer after Helicobacter pylori eradication therapy in patients with peptic ulcer diseases2007
- Author(s)
  Take, S., Mizuno, M., Ishiki, K., Nagahara, Y., Yoshida, T., Yokota, K., Oguma, K
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 21-27
- NAID
  10018539759
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Chronic infections and atherosclerosis2007
- Author(s)
  Ayada K, Yokota K, Kobayashi K, Shoenfeld Y, Matsuura E, Oguma K.
- Journal Title
  
  Ann N Y Acad Sci. 1108
  
  Pages: 594-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Clinical application of Clostridium botulinum type A neurotoxin purified by a simple procedure for patients with urinary incontinence caused by refractory detrusor overactivity2007
- Author(s)
  Lee JC, Yokoyama T, Hwang HJ, Arimitsu H, Yamamoto Y, Kawasaki M, Takigawa T, Takeshi K, Nishikawa A, Kumon H, and Oguma K
- Journal Title
  
  FEMS Immunol. Med. Microbiol. 51
  
  Pages: 201-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Antibodies against heat shock protein 60 derived from Helicobacter pylori: diagnostic implications hl cardiovascular disease.2007
- Author(s)
  Okada T, Ayada K, Usui S, Yokota K, Cui J, Kawahara Y, Inaba T, Hirohata S, Mizuno M, Yamamoto D, Kusachi S, Matsuura E, Oguma K.
- Journal Title
  
  J Autoimmun 29
  
  Pages: 106-115
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Helicobacter pylori heat-shock protein 60 induces interleokin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes2007
- Author(s)
  Zhao, Y., Yokota, K., Ayada, K., Yamamoto, Y., Okada, T., Shen, L., Oguma, K
- Journal Title
  
  J Med Microbiol 56
  
  Pages: 154-164
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Binding properties of Clostridium botulinum type C progenitor toxin to mucins. Biochim2007
- Author(s)
  Nakamura T, Takada N, Tonozuka T, Sakano Y, Oguma K, and Nishikawa A
- Journal Title
  
  Biophys. Acta. 1770
  
  Pages: 551-555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Crystallization and preliminary X-ray analysis of the HA3 component of Clostridium botulinum type C progenitor toxin2007
- Author(s)
  Nakamura T, Tonozuka T, Kotani M, Kanae Obata K, Oguma K and Nishikawa A
- Journal Title
  
  Acta Cryst. F63
  
  Pages: 1038-1040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Chronic infections and atherosclerosis2007
- Author(s)
  Ayada K, Yokota K, Kobayashi K, Okada T, Yoshino T, Shoenfeld Y, Matsuura E, Oguma K
- Journal Title
  
  Annals of New York Academy of Sciences (In press)
- Data Source
  KAKENHI-PROJECT-18590296
[Journal Article] Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR) 2 and mitogen-activated protein (MAP) kinase pathway in human monocytes2007
- Author(s)
  Zhao Y, Yokota K, Ayada K, Yamamoto Y, Okada T, Shen L, Oguma K.
- Journal Title
  
  J Med. Microbiol. 56
  
  Pages: 154-164
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes2007
- Author(s)
  Zhao Y, Yokota K, Ayada K, Yamamoto Y, Okada T, Shen L, Oguma K
- Journal Title
  
  J Med Microbiol. 56
  
  Pages: 154-164
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Chronic infections and atherosclerosis2007
- Author(s)
  Ayada K, Yokota K, Kobayashi K, Shoenfeld Y, Matsuura E, Oguma K.
- Journal Title
  
  Ann N YAcad Sci. 1108
  
  Pages: 594-602
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Antibodies against heat shock protein 60 derived from Helicobacter pylori: diagnostic implications in cardiovascular disease.2007
- Author(s)
  Okada T, Ayada K, Usui S, Yokota K, Cui J, Kawahara Y, Inaba T, Hirohata S, Mizuno M, Yamamoto D, Kusachi S, Matsuura E, Oguma K.
- Journal Title
  
  J Autoimmun. 29
  
  Pages: 106-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Conversion of Flavodoxin from holoenayme to apoprotein during growth phase changes in Helicobacter pylori2007
- Author(s)
  Shimomura H, Hayashi S, Yokota K, Oguma K, Hirai Y.
- Journal Title
  
  J Bacteriol 189
  
  Pages: 4960-4963
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590425
[Journal Article] Application of botulinum neurotoxin to medical treatment.2006
- Author(s)
  Oguma K, et al.
- Journal Title
  
  Igaku no Ayumi. Ishiyaku Shuppann. 216
  
  Pages: 251-252
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390127
[Journal Article] Bacterial toxin and food born poisoning.2006
- Author(s)
  Oguma K, et al.
- Journal Title
  
  IDEN. NTS.
  
  Pages: 143-153
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390127
[Journal Article] Botulinum diseases and Immunity.2005
- Author(s)
  Oguma K.
- Journal Title
  
  Nihon Iji Shinpo. No. 4212
  
  Pages: 95-97
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390127
[Journal Article] ボツリヌス毒素の遺伝子および構造と機能に関する研究(浅川賞受賞論文)2005
- Author(s)
  小熊惠二
- Journal Title
  
  日本細菌学雑誌 60
  
  Pages: 521-531
- Data Source
  KAKENHI-PROJECT-17390127
[Journal Article] The effects of purified newly developed botulinum neurotoxin type A in rat prostate
- Author(s)
  Nishiyama Y, Yokoyama T, Tomizawa K, Okamura K, Lee L. C, Matsui H, Oguma K, Nagai A, Kumon H
- Journal Title
  
  Urology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Journal Article] Molecular analysis of an extrachromosomal element encoding the C2 toxin gene discovered in Clostridium botulinum type C
- Author(s)
  Sakaguchi Y, Hayashi T, Yamamoto Y, Nakayama K, Zhang K, Ma S, Arimitsu H, and Oguma K
- Journal Title
  
  J Bacteriol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390126
[Patent] ボツリヌス毒素由来のポリペプチド及びボツリヌス毒素の検出方法2008
- Inventor(s)
  小熊恵二
- Industrial Property Rights Holder
  小熊恵二
- Industrial Property Number
  2008-272678
- Filing Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-19390126
[Patent] ボツリヌス毒素由来のポリペプチドを有効成分として含む鎮痛作用を有する医薬組成物2008
- Inventor(s)
  窪木拓男、松香芳三、小熊恵二、北村洋一
- Industrial Property Rights Holder
  岡山大学
- Industrial Property Number
  2008-182218
- Filing Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-18390512
[Patent] ボツリヌス毒素由来のポリペプチドを有効成分として含む鎮痛作用を有する医薬組成物2008
- Inventor(s)
  窪木拓男, 松香芳三, 小熊恵二, 北村洋
- Industrial Property Rights Holder
  岡山大学
- Industrial Property Number
  2008-182218
- Filing Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-18390512
[Patent] ボツリヌス毒素由来のポリペプチドを有効成分として含む鎮痛作用を有する医薬組成物2008
- Inventor(s)
  窪木拓男小熊恵二
- Industrial Property Rights Holder
  窪木拓男小熊恵二
- Industrial Property Number
  2008-182218
- Filing Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-19390126
[Patent] ボツリヌス毒素由来のポリペプチドを有効成分として含む鎮痛作用を有する医薬組成物2008
- Inventor(s)
  窪木拓男・小熊惠二
- Industrial Property Rights Holder
  窪木拓男・小熊惠二
- Industrial Property Number
  2008-182218
- Filing Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-19390126
[Patent] ボツリヌス毒素由来のポリペプチド及びボツリヌス毒素の検出方法2008
- Inventor(s)
  小熊惠二
- Industrial Property Rights Holder
  小熊惠二
- Industrial Property Number
  2008-272678
- Filing Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-19390126
[Patent] ボツリヌス毒素由来のポリペプチドを有効成分として含む鎮痛作用を有する医薬組成物2008
- Inventor(s)
  窪木拓男, 松香芳三, 小熊恵二, 北村洋一
- Industrial Property Rights Holder
  基礎
- Industrial Property Number
  2008-182218
- Filing Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-18390512
[Patent] ボツリヌス毒素由来のポリペプチドを有効成分として含む鎮痛作用を有する医薬組成物2007
- Inventor(s)
  窪木拓男, 松香芳三, 小熊恵二, 北村洋一
- Industrial Property Number
  2007-283274
- Filing Date
  2007
- Data Source
  KAKENHI-PROJECT-18390512
[Patent] 動脈硬化の検査法2007
- Inventor(s)
  綾田潔, 横田憲治, 小熊惠二
- Industrial Property Rights Holder
  綾田潔, 横田憲治, 小熊惠二
- Industrial Property Number
  2006-330367
- Acquisition Date
  2007-04-20
- Data Source
  KAKENHI-PROJECT-18590425
[Patent] 糖結合性ポリペプチド、複合材料、及び薬剤送達システム2007
- Inventor(s)
  小熊恵二, 西河淳
- Industrial Property Rights Holder
  国享大学法人岡山大学, 国立大学法人東京農工大学
- Industrial Property Number
  2007-005265
- Filing Date
  2007-01-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390127
[Patent] ボツリヌス毒素成分HAを核酸の細胞内導入キャリアーとして利用する方法2007
- Inventor(s)
  (財)科学及血清療法研究所・小熊惠二
- Industrial Property Rights Holder
  (財)科学及血清療法研究所・小熊惠二
- Industrial Property Number
  2007-251502
- Filing Date
  2007-09-27
- Data Source
  KAKENHI-PROJECT-19390126
[Patent] 動脈硬化の検査法2006
- Inventor(s)
  綾田潔, 横田憲治, 小熊恵二
- Industrial Property Rights Holder
  国立大学法人岡山大学
- Industrial Property Number
  2006-330367
- Filing Date
  2006-12-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Patent] 動脈硬化の検査方法2006
- Inventor(s)
  綾田潔, 横田憲治, 小熊恵二
- Industrial Property Rights Holder
  綾田潔, 横田憲治, 小熊恵二
- Industrial Property Number
  2006-330367
- Filing Date
  2006-12-07
- Data Source
  KAKENHI-PROJECT-18590425
[Presentation] 神経障害性疼痛へのポツリヌス毒素の効果2012
- Author(s)
  松香芳三,丸〓功太郎,三宅愛,山本由弥子,前川賢治,古味桂子,園山亘,小熊惠二,窪木拓男
- Organizer
  日本歯科医学会総会
- Place of Presentation
  インテックス大阪(大阪府)
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] 神経毒素成分を精製した A 型ボツリヌス毒素の三叉神経への取り込みと輸送2012
- Author(s)
  丸〓功太郎, 松香芳三, 山本由弥子, 寺山隆司, 古味佳子, 大野充昭, 前川賢治, 上岡寛, 山城隆, 杉本朋貞, 松下治, 小熊恵二, 窪木拓男
- Organizer
  日本口腔顔面痛学会
- Place of Presentation
  慶応大学(東京都)
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] 神経障害性疼痛へのポツリヌス毒素の効果2012
- Author(s)
  松香芳三, 丸濵功太郎, 三宅愛, 山本由弥子, 前川賢治, 古味桂子, 園山亘, 小熊惠二, 窪木拓男
- Organizer
  日本歯科医学会総会
- Place of Presentation
  (大阪府)インテックス大阪
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] 神経毒素成分を精製したA型ボツリヌス毒素の三叉神経への取り込みと輸送2012
- Author(s)
  丸濵功太郎, 松香芳三, 山本由弥子, 寺山隆司, 古味佳子, 大野充昭, 前川賢治, 上岡寛, 山城隆, 杉本朋貞, 松下治, 小熊恵二, 窪木拓男
- Organizer
  日本口腔顔面痛学会
- Place of Presentation
  (東京都)慶應義塾大学
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
- Author(s)
  Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
- Author(s)
  Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- Organizer
  Society for Neuroscience
- Place of Presentation
  (アメリカ)ワシントン州コンベンションセンター
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
- Author(s)
  Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Medical application of clostridal toxins; 1) Clostridium botulinum neurotoxin2011
- Author(s)
  Oguma K, Yamamoto Y, Suzuki T, Yokoyama T, Matsuka Y, Arimitsu H, Kuboki T
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo Convention Center (北海道)
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Medical application of clostridal toxins ; 1) Clostridium botulinum neurotoxin2011
- Author(s)
  Oguma K
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Hokkaido
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
- Author(s)
  Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  Sapporo Convention Center (北海道)
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Medical application of clostridal toxins; 1) Clostridium botulinum neurotoxin2011
- Author(s)
  Oguma K, Yamamoto Y, Suzuki T, Yokoyama T, Matsuka Y, Arimitsu H, Kuboki T
- Organizer
  International Union of Microbiological Societies 2011 Congress(招待講演)
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Medical application of clostridal toxins; 1) Clostridium botulinum neurotoxin2011
- Author(s)
  Oguma K, Yamamoto Y, Suzuki T, Yokoyama T, Matsuka Y, Arimitsu H, Kuboki T.
- Organizer
  International Union of Microbiological Societies 2011 Congress, Sapporo
- Place of Presentation
  (北海道)札幌コンベンションセンター
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
- Author(s)
  Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC Convention Center (Washington DC, USA)
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-23659897
[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
- Author(s)
  Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  (北海道)札幌コンベンションセンター
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Pepripehral administration of Botlinum toxin type A neurotoxin reverses trigeminal thermal hyperalgesia2010
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Yamamoto K, Murakami K, Kuboki T, Oguma K.
- Organizer
  Asian Academy of Craniomandibular Disorders
- Place of Presentation
  (福岡県)九州大学
- Year and Date
  2010-10-03
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] ベーチェット病患者由来熱ショックタンパクHSP60由来ペプチドの免疫活性の研究2010
- Author(s)
  大野佑子、横田憲治、申蓮花、山本由弥子、小熊惠二
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Peripheral administration of Botulinum toxin type A neurotoxin reverses trigeminal neuropathic pain symptoms2010
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Satoh K, Watanabe K, Kuboki T, Oguma K
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Peripheral administration of Botulinum toxin type A neurotoxin reverses trigeminal neuropathic pain symptoms2010
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Satoh K, Watanabe K, Kuboki T, Oguma K.
- Organizer
  Society for Neuroscience
- Place of Presentation
  (アメリカ)サンディエゴコンベンションセンター
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] Peripheral administration of botulinum toxin type A decreases exaggerated neurotransmitter release from somata of trigeminal ganglion neurons and reverses neuropathy symptoms2010
- Author(s)
  Kumada A, Matsuka Y, Kitamura Y, Spigelman I, Yamamoto Y, Nolan TA, Neubert JK, Ishihara Y, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K
- Organizer
  International Symposium for Future Technology Creating Better Human Health and Society. Molecular Targets for the Development of Therapeutic Agents against Cancer and Infectious Diseases in vitro, in vivo and in silico
- Place of Presentation
  Okayama
- Year and Date
  2010-02-03
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] H.pylori除菌後の再感染についての検討2010
- Author(s)
  武進、水野元夫、石木邦治、喜多雅英、横田憲治、小熊惠二
- Organizer
  第16回日本ヘリコバクター学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] H.pylori感染と冠動脈疾患の関係2010
- Author(s)
  横田憲治、山本由弥子、鈴木智典、長町栄子、小熊惠二
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] ステロイド吸収によって惹起されるピロリ菌のフォスファチジールコリン耐性の発現2010
- Author(s)
  下村裕史、細田浩一、林俊治、横田憲治、小熊惠二、平井義一
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Pepripehral administration of Botlinum toxin type A neurotoxin reverses trigeminal thermal hyperalgesia2010
- Author(s)
  Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Yamamoto K, Murakami K, Kuboki T, Oguma K
- Organizer
  Asian Academy of Craniomandibular Disorders
- Place of Presentation
  Hakata
- Year and Date
  2010-10-03
- Data Source
  KAKENHI-PROJECT-22390365
[Presentation] ピロリ菌におけるステロイドホルモンの同化的利用2010
- Author(s)
  細田浩一、下村裕史、林俊治、横田憲治、小熊惠二、平井義一
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] 三叉神経障害性疼痛モデルに対する改良A型ボツリヌス毒素の鎮痛効果2010
- Author(s)
  熊田愛, 松香芳三, 北村洋一, Igor Spigelman, 山本由弥子, Todd A.Nolan, John K.Neubert, 石原嘉人, 園山亘, 上岡寛, 山城隆, 小熊恵二, 窪木拓男
- Organizer
  神経行動薬理若手研究者の集い
- Place of Presentation
  岡山
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] H.pylori感染と冠動脈疾患の関係2010
- Author(s)
  横田憲治、山本由弥子、鈴木智典、長町栄子、小熊惠二
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] ベーチェット病患者由来熱ショックタンパクHSP60由来ペプチドの免疫活性の研究2010
- Author(s)
  大野佑子、横田憲治、申蓮花、山本由弥子、小熊惠二
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Helicobacter pyloriの除菌後再感染菌の検討2010
- Author(s)
  西田奈々、大野佑子、横田憲治、山本由弥子、鈴木智典、小熊惠二
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Helicobacter pyloriの除菌後再感染菌の検討2010
- Author(s)
  西田奈々、大野佑子、横田憲治、山本由弥子、鈴木智典、小熊惠二
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] H.pylori除菌後の再感染についての検討2010
- Author(s)
  武進、水野元夫、石木邦治、喜多雅英、横田憲治、小熊惠二
- Organizer
  第16回日ヘリコバクター学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] H.pylori感染と冠動脈疾患の関係2010
- Author(s)
  横田憲治、喜多雅英、綾田潔、林俊治、平井義一、小熊惠二
- Organizer
  第16回日本ヘリコバクター学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] ステロイドの抗ピロリ菌活性2010
- Author(s)
  細田浩一、下村裕史、林俊治、横田憲治、小熊惠二、平井義一
- Organizer
  第16回日本ヘリコバクター学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Helicobacter pyloriの病原遺伝子の多様性と胃粘膜萎縮の関係についての検討2010
- Author(s)
  横田憲治、大野佑子、林俊治、平井義一、長町英子、小熊惠二
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Anabolic utilization of steroid hormones in Helicobacter pylori.2009
- Author(s)
  Kouichi Hosoda, Hirofumi Shimomura, Shunji Hayashi, Kenji Yokota, Keiji Oguma, Yoshikazu Hirai.
- Organizer
  International Workshop on Campylobacter, Helicobacter, and Related Organisms(CHRO).
- Place of Presentation
  Niigata
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Helicobacter pylori infection may cause the atherosclerosis via Thl-dominant reactions induced mainly by both bacterial- and host- HSP60s.2009
- Author(s)
  Keiji Oguma, Kiyoshi Ayada, Kenji Yokota, Masahide Kita, Dwi Fatmawati, Eiji Matsuura, Shouzou Kusachi
- Organizer
  International Workshop on Campylobacter, Helicobacter, and Related Organisms (CHRO).
- Place of Presentation
  Niigata
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] 三叉神経領域における実験的神経因性疼痛に対する改良A型ボツリヌス毒素(150kDa)の鎮痛効果2009
- Author(s)
  北村洋一, 松香芳三, 園山亘, 暈貴行, 熊田愛, 小熊恵二, 窪木拓男
- Organizer
  日本補綴歯科学会
- Place of Presentation
  京都
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Peripheral administration of botulinum toxin type A decreases exaggerated neurotransmitter release and reverses neuropathy-induced gene expression changes in trigeminal ganglia2009
- Author(s)
  Kumada A、Matsuka Y、Kitamura Y、Spigelman I、Ishihara Y、Yamamoto Y、Hikasa T、Sonoyama W、Kamioka H、Yamashiro T、Kuboki T、Oguma K
- Organizer
  Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] C 型とD型ボツリヌスC2毒素遺伝子をコードするプラスミドの解析2009
- Author(s)
  阪口義彦、林哲也、中山恵介、山本由弥子、馬少博、橋本夕佳、張凱、小熊惠二
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] Helicobacter pylori感染動脈硬化モデルマウスにおけるT細胞の関与2009
- Author(s)
  綾田潔、横田憲治、平井一行、喜多雅英、小熊惠二
- Organizer
  第15回日本ヘリコバクター学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] H.pylori抗原刺激による胃ガン患者の末梢血マクロファージレセプターDEC205の発現解析2009
- Author(s)
  横田憲治、綾田潔、喜多雅英、岡田裕之、山本和秀、小熊惠二
- Organizer
  第15回日本ヘリコバクター学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Helicobacter pylori infection may cause the atherosclerosis via Thl-dominant reactions induced mainly by both bacterial-and host-HSP60s.2009
- Author(s)
  Keiji Oguma, Kiyoshi Ayada, Kenji Yokota, Masahide Kita, Dwi Fatmawati, Eiji Matsuura, Shouzou Kusachi,
- Organizer
  International Workshop on Campylobacter, Helicobacter, and Related Organisms(CHRO).
- Place of Presentation
  Niigata
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Helicobacter pylori infection may cause the atherosclerosis via Thl-dominant reactions induced HSP60.2009
- Author(s)
  Keiji Oguma, Dwi Fatmawati, Kiyoshi Ayada, Kenji Yokota, Kazuyuki Hirai, Masahide Kita, Eiji Matsuura, Shouzou Kusachi.
- Organizer
  Cell Stress Society International, The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo, Japan.
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Botulinum toxin blocks neurotransmitter release and alleviates neuropathy symptoms2009
- Author(s)
  Kumada A, Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Hikasa T, Kamioka H, Yamashiro T, Sonoyama W, Kuboki T, Oguma K
- Organizer
  The Second International Symposium of Medial and Dental Education in Okayama
- Place of Presentation
  Okayama
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Helicobacter pylori菌の病原遺伝子の多様性と疾患についての検討2009
- Author(s)
  喜多雅英、横田憲治、岡田裕之、武進、綾田潔、竹中龍太、河原祥朗、山本和秀、小熊惠二
- Organizer
  第15回日本ヘリコバクター学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] H. pylori抗原刺激による胃ガン患者の末梢血マクロファージレセプターDEC205の発現解析2009
- Author(s)
  横田憲治、綾田潔、喜多雅英、岡田裕之、山本和秀、小熊恵二
- Organizer
  第15回日本ヘリコバクター学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Anabolic utilization of steroid hormones in Helicobacter pylori.2009
- Author(s)
  Kouichi Hosoda, Hirofumi Shimomura, Shunji Hayashi, Kenji Yokota, Keiji Oguma, Yoshikazu Hirai
- Organizer
  International Workshop on Campylobacter, Helicobacter, and Related Organisms (CHRO).
- Place of Presentation
  Niigata
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease.2009
- Author(s)
  Kenji Yokota, Kiyoshi Ayada, Toshihide Hamada, Kazuyuki Hirai, Tomoari Kamada, Ken Haruma, Keiji Oguma
- Organizer
  International Workshop on Campylobacter, Helicobacter, and Related Organisms (CHRO).
- Place of Presentation
  Niigata
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Helicobacter pyloriによる培養細胞からのサイトカイン誘導性の検討2009
- Author(s)
  横田憲治、綾田潔、武進、水野元夫、小熊惠二
- Organizer
  第15回日本ヘリコバクター学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] Helicobacter pylori infection may cause the atherosclerosis via Thl-dominant reactions induced HSP60. Cell Stress Society International2009
- Author(s)
  Keiji Oguma, Dwi Fatmawati, Kiyoshi Ayada, Kenji Yokota, Kazuyuki Hirai, Masahide Kita, Eiji Matsuura, Shouzou Kusachi.
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo, Japan.
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] 三叉神経領域における実験的神経因性疼痛に対する改良A型ボツリヌス毒素(150 kDa)の鎮痛効果2009
- Author(s)
  北村洋一、松香芳三、園山亘、暈貴行、熊田愛、小熊惠二、窪木拓男
- Organizer
  日本補綴歯科学会
- Place of Presentation
  京都
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease.2009
- Author(s)
  Kenji Yokota, Kiyoshi Ayada, Toshihide Hamada, Kazuyuki Hirai, Tomoari Kamada, Ken Haruma, Keiji Oguma.
- Organizer
  International Workshop on Campylobacter, Helicobacter, and Related Organisms(CHRO).
- Place of Presentation
  Niigata
- Data Source
  KAKENHI-PROJECT-20590445
[Presentation] H. pylori-感染におけるマンノーズレセプターファミリーDEC205の役割2008
- Author(s)
  藤本聖人、横田憲治、綾田潔、平井一行、林俊治、平井義一、小熊恵二
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  京都
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Presentation] Botulinum toxin blocks neurotransmitter release from somata of rat neuropi2008
- Author(s)
  Kitamura Y, Matsuka Y, Ishihara Y, Spigelman I, Yamamoto Y, Sonoyama w, Oguma K, Kuboki
- Organizer
  Botulinum and Tetanus Toxins 2008
- Place of Presentation
  Baveno
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] 三叉神経因性疼痛モデルラツトにおける神経伝達物質遊離に対する改良A型ボツリヌス毒素の効果 -神経因性疼痛に対する新規治療法の開発-2008
- Author(s)
  北村洋一, 松香芳三, 山本由弥子, 小熊恵二, 窪木拓男
- Organizer
  先端歯学スクール2008
- Place of Presentation
  三浦
- Year and Date
  2008-10-20
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Role of DEC205 in H. pylori Infection2008
- Author(s)
  Fujimoto, K., Yokota, K., Ayada, K., Hirai, K., Hyashi, K., Hirai, K., Oguma, K
- Organizer
  80th Nippon Saikin Gakkai
- Place of Presentation
  KYOTO
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Presentation] Botulinum toxin blocks neurotransmitter release from somata of rat neuropathic trigeminal ganglion neurons2008
- Author(s)
  Yoichi, Kitamura, Yoshizo, Matsuka, Yoshihiro, Ishihara, Igor, Spigelman, Yumiko, Yamamoto, Wataru, Sonoyama, Horoshi, Kamioka, Takashi, Yamashiro, Keiji, Oguma and Takuro, Kuboki
- Organizer
  The 6^<th> International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] The effect of peripheral administration of botulinum toxin type A in neuropa2008
- Author(s)
  Matsuka Y, Kitamura Y, Spigelman I, Akther R, Yamamoto Y, Sonoyama W, Oguma K and
- Organizer
  Botulinum and Tetanus Toxins 2008
- Place of Presentation
  Baveno
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Peripheral administration of Botulinum toxin type A blocks neurotransmitter release from somata of trigeminal ganglion neurons and alleviates neuropathy symptoms2008
- Author(s)
  Kitamura Y、Matsuka Y、Spigelman I、Ishihara Y、Akther R、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] 三叉神経因性疼痛モデルラットにおける改良A型ボツリヌス毒素の効果2008
- Author(s)
  北村洋一、松香芳三、石原嘉人、園山亘、山本由弥子、小熊恵二、窪木拓男
- Organizer
  口腔顔面痛学会
- Place of Presentation
  福岡
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Peripheral administration of Botulinum toxin type A blocks neurotransmitter release from somata of trigeminal ganglion neurons and alleviates neuropathy symptoms2008
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Akther R, Yamamoto Y, Sonoyama W, Oguma K, Kuboki T.
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC.
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] H. pylori-感染におけるマンノースレセプターファミリーDEC205の役割2008
- Author(s)
  藤本聖人、横田憲治、綾田潔、平井一行、林俊治、平井義一、小熊惠二
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  京都
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-18590425
[Presentation] Botulinum toxin blocks neurotransmitter release from somata of rat neuropathic trigeminal ganglion neurons2008
- Author(s)
  Kitamura Y、Matsuka Y、Ishihara Y、Spigelman I、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Organizer
  Botulinum and Tetanus Toxins 2008
- Place of Presentation
  Baveno
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] The effect of peripheral administration of botulinum toxin type A in neuropathic pain rats2008
- Author(s)
  Matsuka Y、Kitamura Y、Spigelman I、Akther R、Yamamoto Y、Sonoyama W、Oguma K、Kuboki T
- Organizer
  Botulinum and Tetanus Toxins 2008
- Place of Presentation
  Baveno
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] ボツリヌス毒素および抗体の検出方法の開発2008
- Author(s)
  小熊恵二
- Organizer
  第82回日本感染症学会総会
- Place of Presentation
  島根,日本
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] ボツリヌス毒素および抗体の検出方法の開発2008
- Author(s)
  小熊惠二, 横田憲治, 綾田潔
- Organizer
  第82 回日本感染症学会総会
- Place of Presentation
  島根
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] Clinical application of Clostridium botulinum type A neurotoxin purified by asimple procedure for patients with urinary incontinence caused by refractory detrusor overactivity.2008
- Author(s)
  Oguma K
- Organizer
  The 6th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] The effect of peripheral administration of botulinum toxin type A in ratswith neuropathic pain2008
- Author(s)
  Yoshizo Matsuka, Yoichi Kitamura, Igor Spigelman, Rahena Akther, Yumiko Yamamoto, Wataru Sonoyama, Keiji Oguma and Takuo Kuboki
- Organizer
  The 6^<th> International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins
- Place of Presentation
  Italy
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] 三叉神経因性疼痛モデルラツトにおける改良A型ボツジヌス毒素の効果2008
- Author(s)
  北村洋一, 松香芳三, 石原嘉人, 園山亘, 山本由弥子, 小熊恵二, 窪木拓男
- Organizer
  口腔顔面痛学会
- Place of Presentation
  福岡
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] 三叉神経節細胞の神経伝達物質遊離・取り込みに及ぼす改良A型ボツリヌス毒素の影響2007
- Author(s)
  北村洋一、松香芳三、福田朋樹、小熊惠二、窪木拓男
- Organizer
  日本補綴歯科学会
- Place of Presentation
  神戸
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Botulinum toxin blocks neurotransmitter release from somata of trigeminal ganglion neurons.2007
- Author(s)
  Kitamura Y, Matsuka Y, Spigelman I, Schweizer FE, Oguma K and Kuboki T.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] ボツリヌス症2007
- Author(s)
  小熊惠二
- Organizer
  衛生微生物技術協議会第28回研究会
- Place of Presentation
  岡山,日本
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] Botulinum toxin blocks neurotransmitter release from somata of trigeminal ganglion neurons2007
- Author(s)
  Kitamura Y、Matsuka Y、Spigelman I、Schweizer FE、Oguma K、Kuboki T
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18390512
[Presentation] Expression of endocytoric receptor DEC205 in macrophagei Helicobacter pylori infection2007
- Author(s)
  Yokota K, Zhao Y, Fujimoto K, Ayada K, Hirai K, Oguma K
- Organizer
  107th American Society for Microbiology General Meeting
- Place of Presentation
  Tronto
- Year and Date
  2007-05-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590425
[Presentation] Helicobacter pylori infection and atherosclerosis2007
- Author(s)
  Oguma, K., et. al.
- Organizer
  Japan-China-Korea Joint Conference on Helicobacter pylori Infection
- Place of Presentation
  Pusan, Korea
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590296
[Presentation] ボツリヌスC型HA1の三次構造と糖鎖への結合様式;DDSへの応用2007
- Author(s)
  小熊惠二
- Organizer
  19年度中四国乳酸菌研究会
- Place of Presentation
  岡山,日本
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] Expression of endocytoric receptor DEC205 in macrophagei Helicobacter pylori infection.2007
- Author(s)
  Yokota K, Zhao Y, Fujimoto K, Ayada K, Hirai K, Oguma K
- Organizer
  107th American Society for Microbiology General Meeting
- Place of Presentation
  Tronto
- Year and Date
  2007-05-24
- Data Source
  KAKENHI-PROJECT-18590425
[Presentation] Helicobacter pylori infection and atherosclerosis2007
- Author(s)
  Oguma K
- Organizer
  Japan-China-Korea Joint Conference on Helicobacter Infection
- Place of Presentation
  Pusan, Korea
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590296
[Presentation] Clostridium botulinum Structure of Progenitor toxin ; struc ture and function of hemagglutinin (HA)2007
- Author(s)
  Keiji Oguma
- Organizer
  1^<st> U. S. - Japan Medical Biodef ense Research & Bioterrorism Symposi um USA
- Place of Presentation
  Arlington, USA
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] Clostridium botulinum. Structure of Progenitor toxin; structure and function of hemagglutinin (HA).2007
- Author(s)
  Keiji Oguma.
- Organizer
  1st U.S.-Japan Medical Biodefense Research & Bioterrorism Symposium USA.
- Place of Presentation
  Arlington, USA.
- Data Source
  KAKENHI-PROJECT-19390126
[Presentation] Expression of DEC205 stimulated with H. pylori antigens2006
- Author(s)
  Fujimoto, K., Yokota, K., Ayada, K., Hirai, K., Hyashi, S., Hirai, K., Oguma, K
- Organizer
  81thNippon Saikin Gakkai
- Place of Presentation
  OSAKA
- Year and Date
  2006-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590425

1. YOKOTA Kenji (00243460)

# of Collaborated Projects: 7 results

# of Collaborated Products: 72 results
2. INOUE Kaoru (40260103)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. FUJINAGA Yukako (60252954)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. AYADA Kiyoshi (00379835)

# of Collaborated Projects: 5 results

# of Collaborated Products: 39 results
5. YAMAMOTO Yomiko (20403496)

# of Collaborated Projects: 4 results

# of Collaborated Products: 53 results
6. MATSUKA Yoshizo (90243477)

# of Collaborated Projects: 3 results

# of Collaborated Products: 49 results
7. KUBOKI Takuo (00225195)

# of Collaborated Projects: 3 results

# of Collaborated Products: 48 results
8. KUMADA Ai (40610895)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
9. YOKOSAWA Noriko (50167722)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. FUJII Nobuhiro (90133719)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. HONDA Takeshi (60029808)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SASAKAWA Chihiro (70114494)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. ARIMITSU Hideyuki (40367701)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
14. MAEKAWA Kenji (20304313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
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# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
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# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKEI Koji (40322226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ONO Tsuyoshi (80457225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
19. SAKAGUCHI Yoshihiko (70403491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. MATSUO Ryuji (30157268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YAMAZAKI Shinji (70221653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YOSHIDA Shin-ichi (60128113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. IGARASHI Takashi (70151256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. NAKAZAWA Teruko (40053053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. HAYASHI Hideo (40033203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. DANBARA Hirofumi (40114558)

# of Collaborated Projects: 1 results

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27. TERAWAKI Yoshiro (10014333)

# of Collaborated Projects: 1 results

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28. SUGIMOTO Nakaba (20142317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. TAKAHASHI Motohide (00216764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KOZAKI Shunji (10109895)

# of Collaborated Projects: 1 results

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31. NISHIKAWA Jun (30218127)

# of Collaborated Projects: 1 results

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32. KOUICHI Takeshi (50396339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
33. MATSUURA Eiji (20181688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
34. MAEKAWA Shizue (30045322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 平井義一 (00127581)

# of Collaborated Projects: 1 results

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36. 内山竹彦 (00050550)

# of Collaborated Projects: 1 results

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37. 光山正雄 (10117260)

# of Collaborated Projects: 1 results

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38. 中村信一 (90019620)

# of Collaborated Projects: 1 results

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39. KITAMURA Yoichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
40. TAKEDA Tae

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. LYNN Hughes

# of Collaborated Projects: 1 results

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42. SPIGELMAN Igor

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
43. NEUBERT John k.

# of Collaborated Projects: 1 results

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44. JANET Holden

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45. ROBERT Hirst

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46. HIRST Robert

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48. 竹田多恵

# of Collaborated Projects: 1 results

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OGUMA Keiji 小熊 恵二

小熊 惠ニ オグマ ケイジ

小熊 恵二 オグマ ケイジ

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各種ボツリヌス毒素の腸管よりの吸収機構の解明とその応用Principal Investigator

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Establishment of new procedure for botulism including bioterrorism, and application of botulinum toxin to the treatmentPrincipal Investigator

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Establishment of new procedures for botulism including bio-terrorism and for the treatment of patients with dystonia.Principal Investigator

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Analysis of tertial structure and function of non-toxic components associating with Clostridium botulinum neurotoxins.Principal Investigator

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Analysis of absorption of Clostridium botulinum toxins from the small infestinePrincipal Investigator

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細菌感染症発症機構の分子生物学的手法による解析とその治療への応用Principal Investigator

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OGUMA Keiji 小熊恵二

小熊惠ニオグマケイジ

小熊恵二オグマケイジ