UCHIYAMA Takehiko 内山タケヒコ

Researcher Number	00050550
Affiliation (based on the past Project Information) *help	1991 – 2006 : Tokyo Women's Medical College, School of Medicine, Professor, 医学部, 教授 1996 : Tokyo Wemen's Medical College, Immunology, Professor, 教授
Review Section/Research Field	Principal Investigator 細菌学 / Bacteriology (including Mycology) / Bacteriology (including Mycology) Except Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / Immunology / Immunology / Pediatrics / Embryonic/Neonatal medicine
Keywords	Principal Investigator TSS / superantigen / スーパー抗原 / TCR / T細胞 / TSST-1 / NTED / 外毒素 / T cells / Vβエレメント … More Except Principal Investigator スーパー抗原 / MRSA / T細胞 / superantigen / NTED / CD45 / T cells / IL-4 / IL-2 / 臍帯血 / infectious diseases / signal transduction / 感染症 / 細菌性スーパー抗原 / 胸腺外成熟 / T cell receptor / T細胞サブセット / FOXP3 / ICOS / CD45 isoform / TSST-1 / Lck / 細胞内シグナル伝達機構 / ヒトT細胞 / 新生児TSS様発疹症 / γδT細胞 / post-thymi c maturation / Heat shock protein / renal cell carcinoma / 活性化 / differentiation / TNF-alpha / 補助刺激シグナル / toxic shock syndrome / 胸腺内でのT細胞の分化、選択 / helper T cell differentiation / NKT細胞 / maturation / 抗菌薬 / 細菌感染 / 細胞内シグナル伝達 / Neonatal TSS-like Exanthematous Disease / neonatal toxic shock syndrome-like exanthematous disease / T細胞活性化マーカー / T cell activation / activation / CD26 / ヒト臍帯血 / NKT cells / 細菌 / bacterial super-antigen / NK T細胞 / 主体異常反応 / 川崎病 / LAT / 制御 / co-stimulation / Th cell differentiation / human cord blood / T-cell / abnormal reaction / 制御性細胞 / 腎細胞癌 / differentiation and selection of T cells in the thymus / super antigen / Superantigen / アナジー / 新生児 / 共刺激 / ヘルパーT細胞分化 / 細菌外毒素 / TNF-α / Super Antigen / costimulatory signal / HLA / 免疫寛容 / 外毒素 / TCRVβ2 / STAT5 / SET / human T-cell / アポトーシス / human thymic cells / HHV-6 / human T cells / 内毒素 / T cell activation marker / STATS / 胸腺細胞 / Th2 / T-cell subsets / 制御性T細胞 / 毒素性ショック症候群 / post-thymic muturation / Toxic shock syndrome / ヒト細胞T細胞 / 補助刺激シグナル受容体 / 分化 / TCR Vβ / 標的細胞 / Th1 / 胸腺 / 生体異常反応 / T細胞活性化 / 感染免疫 / regulatory T cells / 病原因子 / TSST- 1 / 成熟 / Kawasaki disease / Bacterial super-antigen / Vβレパトア / neonates / ヒト胸腺細胞 / receptor for costimulatory signal / Co-stimulation / γδT cells / 細菌毒素 / Exotoxin Less

Study on T cell changes in response to infections and its applications
- Principal Investigator
  
  IMANISHI Kenichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical University
Investigation of causative bacteria and host factors involved in the serious infectious diseases caused by Staphylococcus aureusPrincipal Investigator
- Principal Investigator
  
  UCHIYAMA Takehiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical University
The differences of immunological responses of human T cells among thymocytes, cord blood and adult peripheral blood
- Principal Investigator
  
  FUJIMAKI Wakae
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical University
Analysis of the mechanism underlying the induction of type 2 Th cell differentiation by IL-2, IL-4 and ICOS
- Principal Investigator
  
  YAGI Junji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Women's Medical University
Fundamental researches to establish a therapy of neonatal TSS-like exanthematous disease
- Principal Investigator
  
  KATO Hidehito
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical University
新しい感染症、新生児TSS様発疹症の発症機序の基礎的研究
- Principal Investigator
  
  加藤秀人
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical University
Pathopysiology and treatment in emerging infectious disease, Neonatal TSS-like exanthematous disease, induced by exotoxin from MRSA
- Principal Investigator
  
  TAKAHASHI Naoto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Jichi Medical School
  Tokyo Women's Medical University
Multiple analysis of the pathogenic mechanism of an re-emerging infectious disease, neonatal TSS-like exanthematous disease and related diseasesPrincipal Investigator
- Principal Investigator
  
  UCHIYAMA Takehiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Woman's Medical University
Study on human T cell changes in response to infections and applications
- Principal Investigator
  
  IMANISHI Ken-ichi
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical University School of Medicine
Intracellular signal transduction of activated T cells and anergic T cells
- Principal Investigator
  
  FUJIMAKI Wakae
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Woman's Medical University
細菌感染症発症機構の分子生物学的手法による解析とその治療への応用
- Principal Investigator
  
  小熊惠二
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
Studies on differentiation, maturation and activation of human T cells
- Principal Investigator
  
  IMANISHI Ken'ichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical University School of Medicine
Role of a new T cell marker, H4, on the differentiation and selection of T cells in the thymus
- Principal Investigator
  
  YAGI Junji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Women's Medical University
細菌由来病原因子による標的細胞機能変換作用の解析
- Principal Investigator
  
  本田武司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
Intracellular signal transduction of Tcell activated with bacterial super-antigen
- Principal Investigator
  
  FUJIMAKI Wakae
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical University
Study on Etiology and Pathogenesis of Kawasaki Disease
- Principal Investigator
  
  KATO Hirohisa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
スーパー抗原性細菌外毒素によるトレランス誘導・異常反応誘導における役割Principal Investigator
- Principal Investigator
  
  内山竹彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Women's Medical University
Analysis of mechanisms of T cell activation by exotoxins bearing superantigenic properties and induction of abnormal changes by them.Principal Investigator
- Principal Investigator
  
  UCHIYAMA Takehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical College
T cell activation by the exotoxins having superantigenic properties and abonormal reactions observed in patients with the toxin-associated illness.
- Principal Investigator
  
  IMANISHI Ken'ichi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo Women's Medical College
MHCクラスII結合性と超抗原特性をもつ細菌外毒素によるT細胞活性化機序の解析Principal Investigator
- Principal Investigator
  
  内山竹彦
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Tokyo Women's Medical University
Analysis of T cell activation by bacterial extoxins bearing MHC class II-binding activityPrincipal Investigator
- Principal Investigator
  
  UCHIYAMA Takehiko
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Tokyo Women's Medical College

All 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book

[Book] In the comprehensive sourcebook of bacterial protein toxins (3^<rd>edition)2006
- Author(s)
  T.Uchiyama, et al.
- Total Pages
  1072
- Publisher
  Elsevier
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Book] The comprehensive sourcebook of bacterial protein toxins (3^<rd> edition)
- Author(s)
  T.Uchiyama, et al.
- Publisher
  Elsevier(In press)
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] Staphylococcal superantigens and the diseases they cause2006
- Author(s)
  T.Uchiyama et al.
- Journal Title
  
  The comprehensive sourcebook of bacterial protein toxins
  
  Pages : 830-830
- Data Source
  KAKENHI-PROJECT-18590439
[Journal Article] A severe case of neonatal toxic shock syndrome-like exanthematous disease with superantigen-induced high T cell response.2006
- Author(s)
  Miki M, Uchiyama T, et al.
- Journal Title
  
  Pediatr Infect Dis 25・10
  
  Pages : 950-952
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] A severe case of neonatal TSS-like exanthematous disease with superantigen-induced high T cell response.2006
- Author(s)
  M.Miki, T.Uchiyama, et al.
- Journal Title
  
  Pedjatr. Inf. Dis. J. 25
  
  Pages : 950-950
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] A severe case of neonatal toxic shock syndrome-like exanthematous disease with superantigen-induced high T cell response.2006
- Author(s)
  Miki M, Uchiyama T, et al.
- Journal Title
  
  Pediatr Infect Dis J. 25(10)
  
  Pages : 950-2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells.2006
- Author(s)
  Yagi J, Uchiyama T, et al.
- Journal Title
  
  Int Immunol 18(12)
  
  Pages : 1681-90
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells2006
- Author(s)
  Yagi J, Uchiyama T, et al.
- Journal Title
  
  Int Immunol 18・12
  
  Pages : 1681-1690
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Use of DNA arrays to identify a mutation in the negative regulator, csrR, responsible for the high virulence of a naturally occurring type M3 group A streptococcus clinical isolate.2006
- Author(s)
  Miyoshi-Akiyama T, Uchiyama T, et al.
- Journal Title
  
  J Infect Dis. 193(12)
  
  Pages : 1677-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma : a pilot study.2006
- Author(s)
  Kobayashi H, Uchiyama T, et al.
- Journal Title
  
  Cancer Immunol Immunother. (in print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Expression, purification and crystallizaion of Streptococcus dysgalactiae-derived mitogen.2006
- Author(s)
  Papageorgiou AC, Uchiyama T, et al.
- Journal Title
  
  Acta Crystallograph Sect F Struct Biol Cryst Commun 62・Pt3
  
  Pages : 242-244
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Staphylococcal superantigens and diseases caused by them.2006
- Author(s)
  T.Uchiyama, K Imanishi, T.Miyoshi-Akiyama, H.Kato
- Journal Title
  
  In the comprehensive sourcebook of bacterial protein toxins (3^<rd> edition).(Edited by J.E. Alouf and M.R. Popoff. Elsevier.) 830
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] Expression, purification and crystallization of Streptocuccus dysgalactiae-derived mitogen.2006
- Author(s)
  C.Papageorgiou, S.Saarinen, R.Ramirez-Bartuis, H.Kato, T.Uchiyama, T.Kirikae, T.Miyoshi-Akiyama.
- Journal Title
  
  Acta Cryst. 62
  
  Pages : 242-242
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] Staphylococcal superantigens and the diseases they cause2006
- Author(s)
  T., Uchiyama
- Journal Title
  
  The comprehensive sourcebook of bacterial protein toxins
  
  Pages : 830-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590439
[Journal Article] Staphylococcal superantigens and the diseases they cause2006
- Author(s)
  T. Uchiyama, et. al.
- Journal Title
  
  The comprehensive sourcebook of bacterial protein toxins
  
  Pages : 830-843
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590439
[Journal Article] A severe case of neonatal TSS-like exanthematous disease with superantigen-induced high T cell response.2006
- Author(s)
  M.Miki, T.Uchiyama, H.Kato, H.Nishida, N.Takahashi.
- Journal Title
  
  Pediatr.Inf.Dis.J. 25
  
  Pages : 950-950
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] Use of DNA arrays to identify a mutation in the negative regulator, csrR, responsible for the high virulence of a naturally occurringtype M3 group Astreptococcus clinical isolate.2006
- Author(s)
  Miyoshi-Akidyama, T Uchiyama T, et al.
- Journal Title
  
  J Infect Dis 193・12
  
  Pages : 1677-1684
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis.2006
- Author(s)
  Haruta I, Uchiyama T, et al.
- Journal Title
  
  Autoimmunity 39・2
  
  Pages : 129-135
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Expression, purification and crystallization of Streptococcus dysgalactiae-derived mitogen.2006
- Author(s)
  Papageorgiou AC, Uchiyama T, et al.
- Journal Title
  
  Acta Crystallograph Sect F Struct Biol Cryst Commun 62(Pt3)
  
  Pages : 242-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced I-L4 production by naive CD4+ T cells.2006
- Author(s)
  Yagi J, Uchiyama T, et al.
- Journal Title
  
  Int Immunol 18・12
  
  Pages : 1681-1690
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis.2006
- Author(s)
  Haruta I, Uchiyama T, et al.
- Journal Title
  
  Autoimmunity. 39(2)
  
  Pages : 129-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1(TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.2005
- Author(s)
  Nakagawa S, Uchiyama T, et al.
- Journal Title
  
  Clin Diagn Lab Immunol 12・3
  
  Pages : 399-408
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Cytocidal effect of Streptococcus pyogenes on mouse neutrophils in vivo and the critical role of streptolysin S.2005
- Author(s)
  Miyoshi-Akiyama T, Uchiyama T.et al.
- Journal Title
  
  The Journal of Infectious Disease 192
  
  Pages : 107-116
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Prospective surveillance of community-onset and healthcare-associated meticillin-resistant Staphylococcus aureus isolated from a university-affiliated hospital in Japan.2005
- Author(s)
  C-P.Piao, T.Karasawa, K.Totsuka, T.Uchiyama, K.Kikuchi.
- Journal Title
  
  Microbiol.Immunol. 49
  
  Pages : 959-959
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin (TSST)-1, leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.2005
- Author(s)
  S.Nakagawa, K.Kushiya, I.Taneike, K.Imanishi, Uchiyama, T.Yamamoto.
- Journal Title
  
  Clin.Diag.Lab.Immunol.2005 12
  
  Pages : 399-399
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] Characterization of novel staphylococcal enterotoxin-like toxin type P.2005
- Author(s)
  K.Omoe, K.Imanishi, D-L.Hu, H.Kato, Y.Fugane, Y.Abe, S.Hamaoka, Y.Watanabe, A.Nakane, T.Uchiyama, K.Shinagawa.
- Journal Title
  
  Infect.Immune. 73
  
  Pages : 5540-5540
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] CD28 is required for induction and maintenance of immuological memory in toxin-reactive CD4+ T cells in vivo.2005
- Author(s)
  K.Fukada, M.Koyanagi, Y.Arimura, H.Ogiuchi, T.Uchiyama, J.Yagi.
- Journal Title
  
  Cell.Immunol. 238
  
  Pages : 103-103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] Detection of heat shock proteins but not superantigen by isolated oral bacteria from patients with Behcet's disease.2005
- Author(s)
  T.Miura, K.Ishihara, T.Kato, R.Kimizuka, H.Miyabe, T.Ando, T.Uchiyama, K.Okuda.
- Journal Title
  
  Oral Microbiology and Immunology. 20
  
  Pages : 167-167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Journal Article] Specific inhibitory action of anisodamine against a staphylococcal superantigenic toxin, toxic shock syndrome toxin 1 (TSST-1), leading to down-regulation of cytokine production and blocking of TSST-1 toxicity in mice.2005
- Author(s)
  Nakagawa S, Uchiyama T, et al.
- Journal Title
  
  Clin Diagn Lab Immunol. 12(3)
  
  Pages : 399-408
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Cytocidal effect of Streptococcus pyogenes on mouse neutrophils in vivo and the critical role of streptolysin S.2005
- Author(s)
  Miyoshi-Akiyama T, Uchiyama T, et al.
- Journal Title
  
  J Infect Dis. 192(1)
  
  Pages : 107-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo.2005
- Author(s)
  Fukada K, Uchiyama T, et al.
- Journal Title
  
  Cell Immunol 238・2
  
  Pages : 103-112
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Cytocidal effect of Streptococcus pyogenes on mouse neutrophils in vivo and the critical role of streptolysin S.2005
- Author(s)
  Miyoshi-Akiyama T, Uchiyama T, et al.
- Journal Title
  
  J Infect Dis 192・1
  
  Pages : 107-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo.2005
- Author(s)
  Fukada K, Uchiyama T, et al.
- Journal Title
  
  Cell Immunol. 238(2)
  
  Pages : 103-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymicCD4 single-positive T cells in the last stage of maturation2004
- Author(s)
  M.Koyanagi K.Imanishi Y.Arimura H.Kato J.Yagi, T.Uchiyama
- Journal Title
  
  Journal of Infection and Chemotherapy 222
  
  Pages : 315-326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Akt is a neutral amplifier for Th cell differentation.2004
- Author(s)
  Arimura Y, Uchiyama T, et al.
- Journal Title
  
  J Biol Chem 279・12
  
  Pages : 11408-11416
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation.2004
- Author(s)
  Koyanagi M, Uchiyama T, et al.
- Journal Title
  
  Int Immunol 16・2
  
  Pages : 315-326
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Polarization of human CD4+ T cells to T-helper type 1 and type 2 cells by superantigen stimulation.2004
- Author(s)
  Ohnishi A, Fujimaki W, Uchiyama T, et al.
- Journal Title
  
  Journal of Tokyo Women's Medical University 174・3
  
  Pages : 147-156
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] The effects of fluorescent lamp coated with a photocatalyst film on the number of floating microorganisms or smell molecules in a room installed with the lamp.2004
- Author(s)
  Fujimaki W, Uchiyama T, et al.
- Journal Title
  
  Kansenshogaku Zasshi 78・7
  
  Pages : 588-596
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Immunologic immaturity, but high IL-4 productivity, of marine neonatal thymic CD4 single-positive T cells in the last stage f maturation2004
- Author(s)
  Madoka Koyanagi, Takehiko Uchiyama et al.
- Journal Title
  
  Internal Immunology Vol.16, No.2
  
  Pages : 315-326
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] The effects of fluorescent lamp coated with a photocatalyst film on the number of floating microorganisms or smell molecules in a room installed with the lamp.2004
- Author(s)
  Fujimaki W, Uchiyama T, et al.
- Journal Title
  
  Kansenshogaku Zasshi. 78(7)
  
  Pages : 588-96
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Polarization of human CD4+ T cells to T-helper type 1 and type 2 cells by superantigen stimulation.2004
- Author(s)
  Ohnishi A, Fujimaki W, Uchiyama T, et al.
- Journal Title
  
  Journal of Tokyo Women's Medical University 174
  
  Pages : 147-156
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation.2004
- Author(s)
  Koyanagi M, Uchiyama T, et al.
- Journal Title
  
  Int Immunol. 16(2)
  
  Pages : 315-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Akt is a neutral amplifier for Th cell differentiation.2004
- Author(s)
  Arimura Y, Uchiyama T, et al.
- Journal Title
  
  J Biol Chem. 279(12)
  
  Pages : 11408-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Superantigenic Stimulation of Bovine T Cells by Streptococcus dysgalactiae- Derived Mitogen2003
- Author(s)
  MonzeMwaka, H.Kato, T.Hayashi, Y.Abe, T.Akiyama, T.Uchiyama
- Journal Title
  
  東京女子医科大学雑誌 73
  
  Pages : 24-34
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Maturation of adult peripheral blood CD38(+)CD4(+) T cells demonstrated by cytokine production in response to a superantigen, TSST-1.2003
- Author(s)
  K.Imanishi, H.Kato, H.Fujii, T.Uchiyama
- Journal Title
  
  Cellular Immunology 222
  
  Pages : 89-96
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Maturation of adult peripheral blood CD38+CD4+ T cells demonstrated by cytokine production in response to a superantigen, TSST-1.2003
- Author(s)
  Imanishi Ken'ichi, Kato Hidehito, Fujii Hisaichi, Uchiyama Takehiko
- Journal Title
  
  Cell Immunol 222(2)
  
  Pages : 89-96
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Superantigenic Stimulation of Bovine T Cells by Streptococcus dys-galactiae-derived mitogen (SDM).2003
- Author(s)
  Monze Mwaka, H.Kato, T.Hayashi, Y.Abe, T.Akiyama, T.Uchiyama K.Imanishi
- Journal Title
  
  東京女子医科大学雑誌 73
  
  Pages : 24-34
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Early and definitive diagnosis of toxic shock syndrome by detection of marked expansion of T-cell-receptor VBeta2-positive T cells.2003
- Author(s)
  Matsuda Yoshio, Kato Hidehito, Yamada Ritsuko, Okano Hiroya, Ohta Hiroaki, Imanishi Ken'ichi, Kikuchi Ken, Totsuka Kyoichi, Uchiyama Takehiko
- Journal Title
  
  Emerg Infect Dis 9(3)
  
  Pages : 387-389
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Streptococcus dysgalactiae-derived mitogen(SDM), a novel bacterial superantigen : characterization of its biological activity and predicted tertiary structure.2003
- Author(s)
  Miyoshi-Akiyama Toru, Zhao Jizi, Kato Hidehito, Kikuchi Ken, Totsuka Kyoichi, Kataoka Yasushi, Katsumi Masamichi, Uchiyama Takehiko
- Journal Title
  
  Mol Microbiol 47(6)
  
  Pages : 1589-1599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Quantitative and qualitative comparison of virulence traits, including murine lethality, among different M types of group A streptococci.2003
- Author(s)
  Miyoshi-Akiyama Toru, Zhao Jizi, Kikuchi Ken, Kato Hidehito, Suzuki Rieko, Endo Miyoko, Uchiyama Takehiko
- Journal Title
  
  J Infect Dis 187(12)
  
  Pages : 1876-1887
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Superantigenic stimulation of bovine T cells by Streptococcus dysgalactiae-derived mitogen(SDM).2003
- Author(s)
  Monze Mwaka, H.Kato, T.Hayashi, R.Abe, T.Akiyama, T.Uchiyama, K.imanishi
- Journal Title
  
  J Tokyo Women's Med Univ 73(3・4)
  
  Pages : 88-98
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in Th cells and regulates their responses.2002
- Author(s)
  Arimura Yutaka, Kato Hidehito, Dianzani Umberto, Okamoto Toshihiro, Kamekura Soichiro, Buonfiglio Donatella, Miyoshi-Akiyama Toru, Uchiyama Takehiko, Yagi Junji
- Journal Title
  
  Int Immunol 14(6)
  
  Pages : 555-566
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] The percentage of superantigen-reactive T cells in peripheral blood significantly decreasas before massively increasing in early acute phase patients with neonatal TSS-like exanthematous disease.2002
- Author(s)
  H.Kato, N.Takahashi, Y.Arimura, K.Imanishi, H.Nishida, T.Uchiyama
- Journal Title
  
  Journal of Infection and Chemotherapy 8
  
  Pages : 111-114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Superantigen-reactive Vb2+ T cells exhibit a significant reduction before their massive increase in some acute phase patients with TSS-like exanthematous disease.2002
- Author(s)
  Kato Hidehito, Takahashi Naoto, Arimura Yutaka, Imanishi Ken'ichi, Nishida Hiroshi, Uchiyama Takehiko
- Journal Title
  
  J Infect Chemother 8
  
  Pages : 111-114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] The percentage of superantigen-reactive T cells in peripheral blood significantly decreases before massively increasing in early acute phase patients with neonatal TSS-like exanthematous disease.2002
- Author(s)
  H.Kato, N.Takahashi, Y.Arimura, K.Imanishi, H.Nishida, T.Uchiyama
- Journal Title
  
  Journal of Infection and Chemotherapy 8
  
  Pages : 111-114
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Continuous exposure of mice to superantigenic toxins induces a high-level protracted expansion and an immunological memory in the toxin-reactive CD4+ T cells2002
- Author(s)
  Chen Luqiu, Koyanagi Madoka, Fukada Kenji, Imanishi Ken'ichi, Yagi Junji, Kato Hidehito, Miyoshi-Akiyama Toru, Miwa Keishi, Zhang Ruihua, Uchiyama Takehiko
- Journal Title
  
  J Immunol 168
  
  Pages : 3817-3824
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570246
[Journal Article] Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma : a pilot study.
- Author(s)
  Kobayashi H, Uchiyama T, et al.
- Journal Title
  
  Cancer Immunol Immunother (in print)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590372
[Journal Article] Cloning, expression and characterization of the superantigen streptococcal pyrogenic exotoxin-G from Streptococcus dysgalactiae.
- Author(s)
  J.Zhao, T.Hayashi, S.Saarinen, A.C.Papageorgiou, H.Kato, K.Imanishi, T.Kirikae 1, R.Abe, T.Uchiyama, T.Miyoshi-Akiyama.
- Journal Title
  
  Infect.Immun. (In print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390130
[Presentation] 新生児と成人のトキシックショック症候群の診断と発症の現状2006
- Author(s)
  内山竹彦, ほか
- Organizer
  第51回日本ブドウ球菌概究会
- Place of Presentation
  盛岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590439

1. YAGI Junji (70182300)

# of Collaborated Projects : 13results

# of Collaborated Products : 1results
2. IMANISHI Ken'ichi (20132920)

# of Collaborated Projects : 12results

# of Collaborated Products : 14results
3. KATO Hidehito (00241084)

# of Collaborated Projects : 12results

# of Collaborated Products : 20results
4. FUJIMAKI Wakae (90256496)

# of Collaborated Projects : 8results

# of Collaborated Products : 4results
5. IMANISHI Ken'ichi (80124527)

# of Collaborated Projects : 5results

# of Collaborated Products : 0results
6. YAN Xiao-Jie (80195627)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
7. AKIYAMA Toru (20246466)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
8. TANAKA Yoshimasa (90280700)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. KIKUCHI Ken (60214748)

# of Collaborated Projects : 2results

# of Collaborated Products : 1results
10. 本田武司 (60029808)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. 笹川千尋 (70114494)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
12. 中村信一 (90019620)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
13. KATO Hirohisa (30080724)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. YAMANISHI Kouichi (10029811)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. OKUMURA Yasushi (50009700)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. FURUKAWA Susumu (30095830)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. YANAGISAWA Nasayoshi (90049031)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. TAKAHASHI Naoto (50197159)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. NISHIDA Hiroshi (80104553)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. HONMA Youko (10238826)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. ARIMURA Yutaka (10281677)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. MATSUDA Yoshio (10339020)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. 櫻井純 (80029800)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. 篠田純男 (50029782)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. 小熊惠二 (00002262)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. 光山正雄 (10117260)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. 荒明美奈子 (20075427)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

UCHIYAMA Takehiko 内山 タケヒコ

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Investigation of causative bacteria and host factors involved in the serious infectious diseases caused by Staphylococcus aureusPrincipal Investigator

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Multiple analysis of the pathogenic mechanism of an re-emerging infectious disease, neonatal TSS-like exanthematous disease and related diseasesPrincipal Investigator

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UCHIYAMA Takehiko 内山タケヒコ