SAKURAI Jun 櫻井純

… Alternative Names

桜井純サクライジュン

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Researcher Number	80029800
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011: 徳島文理大学, 薬学部, 教授 1992 – 2008: 徳島文理大学, 薬学部, 教授 1987 – 1990: 徳島文理大学, 薬学部, 教授 1986: 徳島文理大, 薬学部, 教授
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / 細菌学 / Bacteriology (including Mycology) Except Principal Investigator Structural biochemistry / Bacteriology (including Mycology) / 細菌学 / General medical chemistry
Keywords	Principal Investigator ウエルシュ菌 / α毒素 / ホスファチジン酸 / Clostridium perfringens / 結晶解析 / リン脂質代謝 / ウェルシュ菌 / ホスフォリパーゼD / Bacillus cereus / 溶血 … More / アラキドン酸 / 溶血作用 / ホスフォリパーゼC / GTP-結合タンパク質 / ガス壊疽 / プロテインキナーゼC / Phospholipase C / Site-directed-mutagenesis / Hemolysis / Rho / Rho-GDI / イオタ毒素 / アミノ酸残基 / アミノ酸置換 / ADPリボシル化酵素 / セレウス菌 / スフィンゴミエリナーゼ / 二価金属イオン / スフィンゴミエリン / ホスホリパ-ゼC / 血小板 / GTP結合タンパク質 / 遺伝子 / 亜鉛 / ヒスチジン残基 / 特異的部位変異法 / 亜鉛タンパク質 / 溶血機構 / ウェルシュ菌α毒素 / 血管収縮 / 血小板凝集 / 【Ca^(2+)】 / アラキドン酸カスケード / 部位特異変異法 / ヒスチジン / alpha毒素 / ホスファチジル4,5-二リン酸 / alpha Toxin / Phospholipase D / Phospholipid metabolism / Histidine / 細胞内情報伝達系 / 低分子量Gタンパク値 / ミオグロビン / 低分子量Gタンパク質 / ガス壊疸 / ガス破疽 / 細菌内情報伝達系 / ARF / Alpha-toxin / phospholipase D / i_a成分 / X線結晶解析 / ADP-リボシル化 / NAD^+ / 毒素ファミリー / ADPリボシル化毒素 / カイネティク解析 / NADディハイドロゲナーゼ活性 / ADPリボシル転移活性 / アクチン / iotaa component / ADP-Ribosylation / NAD / crystallogaraphy / site-directed mutagenesis / ADP-ribosylatiing toxin / Sn1 type reaction / 二成分毒素 / ADPリボシル化 / オリゴマー / リピッドラフト / エンドサイトーシス / エンドソーム / 部位特異的変異法 / ドメイン / Clostrdium perfringens / Iota-toxin / binary toxin / ADP ribosylation / oligomer / lipid raft / endocytosis / endosome / リン脂質 / スフィンゴシン1-リン酸 / Clostridium perfrngens / alpha-toxin / sphinogmyelinase / crystal analysis / hemolysis / divalent metal cation / phospholipid / 溶血活性 / 三次元構造 / 中性SMaseファミリー / クレフト / sphingomyelinase / hemolytic activity / structural analysis / divalent cation / cleft / 3D structure / neutral SMase / 腸管 / 回腸 / 収縮 / Caチャンネル / プロテインキナーゼC / ホスファチジルイノシトール / トロンボキサンA_2 / Alpha toxin / Ileum / Contraction / Ca channel / Protein kinase C … More Except Principal Investigator スフィンゴミエリナーゼ / 結晶構造解析 / X線結晶構造解析 / Pseudomonas cepatia / 細菌 / 病原因子 / 標的細胞 / 制御 / 抗菌薬 / 構造生物学 / スフィンゴミエリン代謝酵素 / スフィンゴシンキナーゼ / スフィンゴミエリン代謝系酵素 / スフィンゴシン1リン酸 / 巻き戻し / 結晶化 / 局在化 / C3 / RhoA / Ia / アクチン / モノADPリボシル化 / 特異性 / 複合体結晶構造解析 / ADPリボシルトランスフェラーゼ / 細菌毒素 / 複合体解析 / C3毒素 / 溶血毒素 / 細胞溶解毒 / 赤血球 / 腸炎ビブリオ / 黄色ブドウ球菌 / ウェルシュ菌 / Vibrio vulnificus / Hemolysin / Cytolysin / Erythrocytes / Vibrio parahaemolyticus / ibrio vulnificus / Staphylococcus aureus / Clostridium perfringens / リン脂質 / スフィンゴミエリン / セラミド / 金属結合 / 膜結合 / アポトーシス / 脂質ラフト / 酵素 / 阻害剤 / sphingomyelinase / ceramide / apotosis / metal-binding Less

Structural and functional basis of the complex of mono-ADP-ribosylating toxin and substrate protein
- Principal Investigator
  
  TSUGE Hideaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto Sangyo University
  Tokushima Bunri University
Structural and cell biological study of sphingolipid metabolic enzyme
- Principal Investigator
  
  TSUGE Hideaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokushima Bunri University
Structural analysis for enzymatic activity of sphingomyelinase from Bacillus cereusPrincipal Investigator
- Principal Investigator
  
  SAKURAI J.
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokushima Bunri University
Structural basis of the neutral sphingomyelinase to understand the lipid raft
- Principal Investigator
  
  TSUGE Hideaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokushima Bunri University
Molecular biological and structural analysis of toxic and enzymatic activities in Clostridium perfringens alpha-toxinPrincipal Investigator
- Principal Investigator
  
  SAKURAI J.
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokushima Bunri University
Molecular biological and crystallographycal anaylsis of Clostridium perfringens iota-toxinPrincipal Investigator
- Principal Investigator
  
  SAKURAI J.
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokushima Bunri University
Crystallographical and molecular biological analysis of ia component of C. perfringens iota-toxinPrincipal Investigator
- Principal Investigator
  
  SAKURAI J
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokushima Bunri University
Mechanism of membrane damage induced by Clostridium perfringens α toxinPrincipal Investigator
- Principal Investigator
  
  SAKURAI Jun
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokushima Bunri University
細菌由来病原因子による標的細胞機能変換作用の解析
- Principal Investigator
  
  HONDA Takesh
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
ウエルシュ菌α毒素の溶血作用と関連する細胞内情報伝達系の解析Principal Investigator
- Principal Investigator
  
  櫻井純
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokushima Bunri University
Biochemical studies on the relationship between Clostridium perfringens alpha toxin and CTP-binding protein in rabbit erythrocytes.Principal Investigator
- Principal Investigator
  
  SAKURAI Jun
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokushima Bunri University
生化学的アプローチ、および、遺伝子操作によるウェルシュ菌α毒素の作用機構の解析Principal Investigator
- Principal Investigator
  
  櫻井純
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Tokushima Bunri University
ウェルシュ菌α毒素の動物細胞に対する作用機構Principal Investigator
- Principal Investigator
  
  櫻井純
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Tokushima Bunri University
Molecular Genetic Analysis and Mechanism of Action of Bacterial Cytolysins
- Principal Investigator
  
  SHINODA Sumio
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  細菌学
- Research Institution
  Okayama University
Biochemical and pharmacological studies on Clostridium perfringens alpha toxinPrincipal Investigator
- Principal Investigator
  
  SAKURAI Jun
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Tokushima Bunri University
ウェルシュ菌α毒素の生化学的並びに薬理学的研究Principal Investigator
- Principal Investigator
  
  桜井純
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Tokushima Bunri University

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] スタンダード薬学シリーズ5感染症の現状とその予防2007
- Author(s)
  櫻井純
- Total Pages
  457
- Publisher
  東京化学同人
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Book] スタンダード薬学シリーズ4 生物系薬学 I.生命体の成り立ち2005
- Author(s)
  櫻井純
- Publisher
  東京化学同人
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Clostridium perfringens Iota-Toxin : Structure and Function2009
- Author(s)
  Sakurai J., Tsuge H., 等
- Journal Title
  
  Toxins. 1
  
  Pages: 208-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570121
[Journal Article] Involvement of tumour necrosis factor-a in Closttidium perfringens β-toxin-induced plasma extravasation in mice2008
- Author(s)
  M.Nagahama, A.Kihara, H.Kintoh, M.Oda and J.Sakurai
- Journal Title
  
  British Journal of Pharmacology 153
  
  Pages: 1296-1302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] The relationship between the metabolism of sphingomyelin species and hemolysis of-sheep erythrocytes induced by Clostridium pelfringens alpha-toxin.2008
- Author(s)
  M. Oda, T. Matsuno, R. Shiihara, S. Ochi, R. Yamauchi, Y. Saito, H. Imagawa, M. Nagahama, M. Nishizawa, J. Sakurai.
- Journal Title
  
  J. Lipid Res. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] The relationship between the metabolism of sphingomyelin species and hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin2008
- Author(s)
  M.Oda, T.Matsuno, R.Shiihara, S.Ochi, R.Yamauchi, Y.Saito, H.Imagawa, M.Nagahama, M.Nishizawa and J.Sakurai
- Journal Title
  
  J.Lipid Res. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens iota-toxin2008
- Author(s)
  Tsuge H., Nagahama M., Oda M., Sakurai J. et al.
- Journal Title
  
  Proc Natl Acad Sci U.S.A. 105-21
  
  Pages: 7399-7404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570113
[Journal Article] Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidyl-choline on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes2007
- Author(s)
  M.Nagahama, A.Otsuka, M.Oda, R.K.Singh, Z.M.Zyta, H.Imagawa, M.Nishizawa, and J.Sakurai
- Journal Title
  
  Biochim.Biophys.Acta-Biomembrane 1768
  
  Pages: 2940-2945
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane damaging action of Clostridium perfringens alpha-toxin toward liposomes2007
- Author(s)
  M.Nagahama, A.Otsuka, M.Oda, R.K.S., Ziora M.Zyta, H.I., M.Nishizawa, J.Sakurai
- Journal Title
  
  Biochim.Biophys.Acta-Biomembrane 1768
  
  Pages: 2940-2945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes.2007
- Author(s)
  M. Nagahama, A. Otsuka, M. Oda, R. K. Singh, Z. M. Zyta, H. Imagawa, M. Nishizawa, J. Sakurai
- Journal Title
  
  Biochim. Biophys. Acta 1768
  
  Pages: 2940-2945
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] The signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils2006
- Author(s)
  M.Oda, S.Ikari, T.Matsuno, Y.Morimune, M.Nagahama, J.Sakurai
- Journal Title
  
  Infect. Immun. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Oligomerization of Clostridium perfringens E -toxin is dependent upon membrane fluidity in liposomes. M. Nagahama2006
- Author(s)
  H. Hara, M. Fernandez-Miyakawa, Y. Itohayashi, J. Sakurai
- Journal Title
  
  Biochemistry 45
  
  Pages: 296-302
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Oligomerization of Clostridium perfringens ε-toxin is dependent upon membrane fluidity in liposomes2006
- Author(s)
  M.Nagahama, H.Hara, M.Fernandez-Miyakawa, Y.Itohayashi, J.Sakurai
- Journal Title
  
  Biochemistry 45
  
  Pages: 296-302
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Structural basis of the sphingomyelin phosphodiesterase activity in natural Sphingomyelase frm Bacillus cereus2006
- Author(s)
  H. Ago, M. Oda, M. Takahashi, H. Tsuge, S. Ochi, N. Katunuma, M. Miyano, J. Sakurai.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 16157-1616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Signal transductio mechanism involved in Clostridium perfringens alpha-toxin-indued superoxide anion generation in rabbit neutrophilus2006
- Author(s)
  M.Oda, S.Ikari, T.Matsuno, Y.Morimune, M.Nagahama, J.Sakurai
- Journal Title
  
  Infection and Immunity 74
  
  Pages: 2876-2886
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Clostridium perfringens beta-toxin; characterization and action2006
- Author(s)
  J.Sakurai, M.Nagahama
- Journal Title
  
  J.Toxicol.Toxin Rev. 25
  
  Pages: 89-108
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Structural basis of the sphingomyelin phosphodiesterase activity in Neutral sphingomyelinase from Bacillus cereus2006
- Author(s)
  H.Ago, M.Oda, M.Takahashi, H.Tshge, S Ochi, N.Katunuma, N.Miyano, J.Sakurai
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 16157-16167
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] The signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils2006
- Author(s)
  M.Oda, S.Ikari, T.Matsuno, Y, Morimune, M.Nagahama, J.Sakurai
- Journal Title
  
  Infect.Immun. (In press)
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Structural basis of the sphingomyelin phosphodiesterase activity in natural sphingomyelase from Bacillus cereus2006
- Author(s)
  H.Ago, M.Oda, M.Takahashi, H.Tsuge, S.Ochi, N.Katunuma, M.Miyano and J.Sakurai
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 16157-16167
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] ウエルシュ菌主要毒素の構造と機能及び活性発現機構に関する研究2006
- Author(s)
  櫻井純
- Journal Title
  
  日本細菌学雑誌 61
  
  Pages: 367-379
- NAID
  10018643349
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Clostridium perfringens beta-toxin : characterization and action2006
- Author(s)
  M.Nagahama, J.Sakurai
- Journal Title
  
  Toxin Rev. 25
  
  Pages: 89-108
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Oligomerization of Clostridium perfringens ε-toxin isdependent upon membrane fluidity in liposomes2006
- Author(s)
  M.Nagahama, H.Hara, M.F-Miyakawa, Y.Itohayashi, J.Sakurai
- Journal Title
  
  Biochemistry 45
  
  Pages: 296-302
- Data Source
  KAKENHI-PROJECT-18590441
[Journal Article] Oligomerization of Clostridium perfringens a-toxin is dependent upon membrane fluidity in liposomes2006
- Author(s)
  M.Nagahama, H.Ham, M.Femandez- Miyakawa, Y.Itohayashi, J.Sakurai
- Journal Title
  
  Biochemistry 45
  
  Pages: 296-302
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Clostridium perfringens beta-toxin : characterization and action.2006
- Author(s)
  M.Nagahama, J.Sakurai
- Journal Title
  
  Toxin Rev. 25
  
  Pages: 89-108
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Clostridium perfringens- epsilon-toxin increases permeability single perfused micovessels of rat mesentery2005
- Author(s)
  RH.Adamson, J.C.Ly, M.Femandez Miyakawa, S.Ochi, J.Sakurai, F.Uzal, F.E Curry
- Journal Title
  
  Infect. Immun. 73
  
  Pages: 4879-4887
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Clostridium perfringens epsilon-toxin increases permeability single perfused micovessels of rat mesentery2005
- Author(s)
  R.H.Adamson, J.C.Ly, M.Fernandez Miyakawa, S.Ochi, J.Sakurai, F.Uzal, F.E.Curry
- Journal Title
  
  Infect.Immun. 73
  
  Pages: 4879-4887
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2)2005
- Author(s)
  H.Zhai, K.Nakade, Y.Oda, M.Mitsumoto, M.Akagi, J.Sakurai, Y.Fukuyama
- Journal Title
  
  Eur.J.Pharmacol. 516
  
  Pages: 112-117
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Role of tyrosine-57 and -65 in membrane-damaging and sphingomyelinase activities of Clostridium perfringens alpha-toxin2005
- Author(s)
  M.Nagahama, A.Otsuka, J.Sakurai
- Journal Title
  
  Biochim.Biophys.Acta 1762
  
  Pages: 110-114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).2005
- Author(s)
  H.Zhai, K.Nakade, Y.Oda, M.Mitsumoto, M.Akagi, J.Sakurai, Y.Fukuyama
- Journal Title
  
  Eur.J.Pharmacol. 516
  
  Pages: 112-117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Role of tyrosine-57 and -65 in membrane-damaging and sphingomyelinase activities of Clostridium perfringens alpha-toxin2005
- Author(s)
  M.Nagahama, A.Otsuka, J.Sakurai.
- Journal Title
  
  Biochim. Biophys. Acta 1762
  
  Pages: 110-114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Clostridium perfringens epsilon-toxin increases permeability single perfused micovessels of rat mesentery.2005
- Author(s)
  R.H.Adamson, J.C.Ly, M.Fernandez Miyakawa, S.Ochi, J.Sakurai, F Uzal, F.E.Curry
- Journal Title
  
  Infect.Immun. 73
  
  Pages: 4879-4887
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal- regulated kinases (ERK1/2)2005
- Author(s)
  H.Zhai, K.Nakade, Y.Oda, M.Mitsumo o, M.Akagi, J.Sakurai, Y.Fukuyama
- Journal Title
  
  Eur. J. Pharmacol. 516
  
  Pages: 112-117
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Binding and internalization of Clostridium perfringens Iota-toxin in lipid rafts2004
- Author(s)
  M.Nagahama, A.Yamaguchi, T.Hagiyama, N.Ohkubo, K.Kobayashi, J.Sakurai
- Journal Title
  
  Infect.Immun. 72
  
  Pages: 3267-3275
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Clostridium perfringens α-toxin activates the sphingomyelin metabolism system in sheep erythrocytes2004
- Author(s)
  S.Ochi, M.Oda, H.Matsuda, S.Ikari, J.Sakurai
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 12181-12189
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] Clostridium perfringens alpha-toxin : characterization and mode of action2004
- Author(s)
  J.Sakurai, M.Nagahama, M.Oda
- Journal Title
  
  J.Biochem. 136
  
  Pages: 569-574
- NAID
  10016203261
- Data Source
  KAKENHI-PROJECT-16590376
[Journal Article] The signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils.
- Author(s)
  M.Oda, S.Ikari, T.Matsuno, Y.Morimune, M.Nagahama, J.Sakurai
- Journal Title
  
  Infect.Immun. (In Press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590376
[Presentation] セレウス菌スフィンゴミエリナーゼの細胞膜結合領域の解析2007
- Author(s)
  橋本学, 小田真隆, 津下英明, 勝沼信彦, 永浜政博, 櫻井純
- Organizer
  第60回日本細菌学会中国・四国支部総会
- Place of Presentation
  岡山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Presentation] セレウス菌スフィンゴミエリナーゼの細胞膜結合領域の解析2007
- Author(s)
  橋本学, 小田真隆, 津下英明, 勝沼信彦, 永浜政博, 櫻井純
- Organizer
  第60回日本細菌学会中国・四国支部総会
- Place of Presentation
  第60回日本細菌学会中国・四国支部総会
- Data Source
  KAKENHI-PROJECT-18590441
[Presentation] アルギニンADPリボシル化の毒素のアクチン認識分子機構2007
- Author(s)
  津下英明、小田真隆、櫻井純, 等
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  パシフィコ横浜会議センター(横浜市)
- Data Source
  KAKENHI-PROJECT-19570113
[Presentation] アルギニンADPリボシル化の毒素のアクチン認識分子機構2007
- Author(s)
  津下英明, 小田真隆, 櫻井純等
- Organizer
  第45 回日本生物物理学会年会
- Place of Presentation
  パシフィコ横浜会議センター(横浜市)
- Data Source
  KAKENHI-PROJECT-19570113
[Presentation] Role of Tyrosin-57 and-65 in biological and sphingomyelinase activities of Clostridium perfringens alpha-toxin.2006
- Author(s)
  OM. Nagahama, A. Otsuka, K. Kobayashi, J. Sakurai
- Organizer
  The 8th Japan-Korea International Symposium on Microbiology
- Place of Presentation
  Kanazawa, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Presentation] Clostridium perfringens alpha-toxin induces superoxide anion generation in rabbit neutrophils.2006
- Author(s)
  OM. Oda, J. Sakurai
- Organizer
  The 8th Japan-Korea International Symposium on Microbiology
- Place of Presentation
  Kanazawa, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Presentation] Oligomerization of Clostridium perfringens epsilon-toxin is dependent on membrane fluidity in liposomes.2006
- Author(s)
  OM. Nagahama, K. Kobayashi, H. Hara, M. Fernandes Miyakawa, J. Sakurai
- Organizer
  Clostpath
- Place of Presentation
  Nottingham, UK
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590441
[Presentation] Clostridium perfringens alpha-toxin induces superoxide anion generation in rabbit neutrophils.2006
- Author(s)
  OM. Oda, S. Ikari, T. Matsuno, Y. Morimune, J. Sakurai
- Organizer
  Clostpath
- Place of Presentation
  Nottingham, UK
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590441

1. KOBAYASHI Keiko (90170315)

# of Collaborated Projects: 11 results

# of Collaborated Products: 3 results
2. NAGAHAMA Masahiro (40164462)

# of Collaborated Projects: 10 results

# of Collaborated Products: 11 results
3. TSUGE Hideaki (40299342)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
4. ODA Masataka (00412403)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
5. FUJII Yoshio (60122587)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. OCHI Sadayuki (80268705)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. HONDA Takesh (60029808)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SHINODA Sumio (50029782)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KATUNUMA Nobuhiko (50035375)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TSURUMURA Toshiharu (50450250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAZAWA Teruko (40053053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIZUGUCHI Yasuo (10072919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NODA Masatoshi (60164703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIYANO Masashi (80332287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. AGO Hideo (70360477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 笹川千尋 (70114494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 内山竹彦 (00050550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中村信一 (90019620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 加藤巌 (40012702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKURAI Jun 櫻井 純

桜井 純 サクライ ジュン

Research Projects

Research Products

Co-Researchers

Structural and functional basis of the complex of mono-ADP-ribosylating toxin and substrate protein

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Structural and cell biological study of sphingolipid metabolic enzyme

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Structural analysis for enzymatic activity of sphingomyelinase from Bacillus cereusPrincipal Investigator

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Structural basis of the neutral sphingomyelinase to understand the lipid raft

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Molecular biological and structural analysis of toxic and enzymatic activities in Clostridium perfringens alpha-toxinPrincipal Investigator

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Molecular biological and crystallographycal anaylsis of Clostridium perfringens iota-toxinPrincipal Investigator

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Crystallographical and molecular biological analysis of ia component of C. perfringens iota-toxinPrincipal Investigator

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Mechanism of membrane damage induced by Clostridium perfringens α toxinPrincipal Investigator

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細菌由来病原因子による標的細胞機能変換作用の解析

Principal Investigator

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ウエルシュ菌α毒素の溶血作用と関連する細胞内情報伝達系の解析Principal Investigator

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Biochemical studies on the relationship between Clostridium perfringens alpha toxin and CTP-binding protein in rabbit erythrocytes.Principal Investigator

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生化学的アプローチ、および、遺伝子操作によるウェルシュ菌α毒素の作用機構の解析Principal Investigator

Principal Investigator

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ウェルシュ菌α毒素の動物細胞に対する作用機構Principal Investigator

Principal Investigator

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SAKURAI Jun 櫻井純

桜井純サクライジュン