HAYASHI Norio 林典夫

Researcher Number	00004606
Affiliation (based on the past Project Information) *help	1999: Tohoku University, Graduate School of Medicine, Professor 1999: 東北大学, 大学院・医学系研究科, 教授 1995 – 1999: 東北大学, 医学部, 教授 1991 – 1993: 東北大学, 医学部, 教授 1987 – 1989: Tohoku University School of Medicine, 医学部, 教授 1986: Tohoku University School of Medicine, 医学部, 教授 1985: 東北大学, 医, 教授
Review Section/Research Field	Principal Investigator Pathological medical chemistry / General medical chemistry / Functional biochemistry Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator 転写因子 / Bach1 / δ-アミノレブリン酸合成酵素 / GATA-2 / NF-E2 / 5-アミノレブリン酸合成酵素 / 鉄芽球性貧血 / MafK / cDNA / アイソザイム … More / 転写調節 / 造血細胞 / プロモーター / 遺伝子 / Heme / ヘム / コプロポルフィリノーゲンオキシダーゼ / ヘム調節モチーフ / Bach2 / GATA-1 / M-TAT細胞 / ヘム生合成 / δーアミノレブリン酸合成酵素 / 酵素精製 / 遺伝子導入マウス / 白血病細胞 / 選択的プロモーター / 造血細胞特異的エンハンサー / GATA-2因子 / 造血前駆細胞 / 白血病 / GATA因子 / 血球分化 / 骨髄性プロトポルフィリン症 / フェロキラターゼ / regeneration of pancreatic <beta>-cells / aromatic acid amides / oxygen radicals / insulin-dependent diabetes / streptozotocin / alloxan / 90 % depancreatized rats / DNA複製 / ラジカルスカベンジャー / 芳香族酸アミド / 膵切除ラット / 糖尿病治療薬 / reg(regenerating gene) / 再生膵B細胞 / 膵ランゲルハンス島 / アロキサン、ストレプトゾトシン / 糖尿病治療藥 / 膵ランゲルハンス島β細胞再生 / 芳香族酸アミド化合物 / 活性酸素 / インスリン依存性糖尿病 / ストレプトゾトシン / アロキサン / 90%膵切除ラット / Isozyme / Purification / <delta> -Aminolevulinate Synthase / Transgenic mice / Knockout mice / Erythroid cells / モデル動物 / 赤血球分化 / 環状鉄芽球 / 鉄代謝 / 遺伝子改変マウス / トランスジェニックマウス / ノックアウトマウス / 赤血球系細胞 / Heme-oxygenase 1 / Transcription / ヘムオキシゲナーゼ / Nrf3 / ヘム生合成調節 / ヘムオキシゲナーゼ1 / 転写 / coproporphyrinogen oxidase / 5-aminolevulinate synthase / heme regulatory motif / メロンボポエチン / Bach因子 / p45 / transgenic mouse / hematopoiesis / leukemia cells / promoter / enhancer / transcription factor / 病型診断 / MLP / トロンボポエチン / GATA-1因子 / regulatory region / rat / gene / heme biosynthesis / delta-aminolevulinate synthase / フィードバック調節 / 調節領域 / ラット / δアミノレブリン酸合成酵素 / 赤芽球 / エンハンサー / Maf / 5-アミルブルン酸合成酵素 / 遺伝子解析 / 骨髓性プロトポルフィリン症 / フェロキタラ-ゼ / 5‐アミノレブリン酸合成酵素 … More Except Principal Investigator NF-E2p45 / GATA-1 / GATA-2 / 造血幹細胞 / thrombopoetin / erythropoietin / hematopoietic stem cell / erythrocyte / megakaryoyte / ETSファミリー / NF-E2 / 転写因子 / MPL / トロンボポエチン / エリスロポエチン / 増血幹細胞 / 赤血球 / 巨核球 / NF-E2 p45 / 緑色蛍光タンパク質(GFP) / トランスジェニックマウス / 転写調節機構 / 白血病 / 遺伝子解析 / 転写制御 / T細胞受容体 / GATA転写因子 Less

転写因子GATA-2の造血幹細胞と白血病細胞における発見と機能
- Principal Investigator
  
  峯岸直子
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  University of Tsukuba
白血病細胞における転写因子GATA-2の転写調節機構の解析Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Roles of heme in the regulation of gene expression and cell differentiation of erythroid cellsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
Gene manipulation of heme synthetic pathway enzymesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
白血病細胞における転写因子GATA-2発現の役割とインターフェロンの効果Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
血球分化に関与する転写因子群の解析とその造血細胞腫瘍診断への応用Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Regulation of erythroid differentiation by trnscription factors and hemePrincipal Investigator
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
Transcription factors regulating the erytnroid and megakaryocytic cell differentiation.
- Principal Investigator
  
  MINEGISHI Naoko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Tsukuba
  Tohoku University
血球分化に関与する転写因子群の解析とその造血細胞腫瘍診断への応用Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Analysis of the expression profile of lineage-specific transcription factors in leukemia cellsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髄性プロトポルフィリン症Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髄性プロトポルフィリン症Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Structure and function of the regulatory region of the gene encoding non-specific form delta-aminolevulinate synthasePrincipal Investigator
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
転写因子GATA(NF‐EI)群をコ-ドする遺伝子の構造と発現調節機序の解析
- Principal Investigator
  
  YAMAMOTO Masayuki
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髓性プロトポルフィリン症Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
赤芽球でのヘム生合成調節とその病態の研究-δ-アミノレブリン酸合成酵素の役割Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
実験的ポルフィリン症の発症機構とヘム生合成系酵素の組織差に関する研究Principal Investigator
- Principal Investigator
  
  林典夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tohoku University
Heme Regulation of Synthesis and Intracellular Localization of <delta> -Aminolevulinate Synthase IsozymesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  TOHOKU UNIVERSITY
Establishment of experimental models for insulin-dependent diabetes and exploitation of novel drugs for the treatment of diabetesPrincipal Investigator
- Principal Investigator
  
  HYAHI Norio
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  TOHOKU UNIVERSITY

All 1999 1998

All Journal Article

[Journal Article] Molecular cloning and functional characterization of a new CNC family transcription factor Nrf3.1999
- Author(s)
  Kobayashi, A., Itoh, E., Toki, T., Takahashi, S-i, Igarashi, K., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J. Biol. Chem. 274
  
  Pages: 6443-6452
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Molecular cloning and functional characterization of a new CNC family transcription factor Nrf3.1999
- Author(s)
  Kobayashi, A., Itoh, E., Toki, T., Takahashi, S-i, Igarashi, K., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J. Biol. Chem. 274
  
  Pages: 6443-6452
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10557015
[Journal Article] Molecular cloning and functional characterization of a new CNC family transcription factor Nrf31999
- Author(s)
  Kobayashi, A., Itoh, E., Toki, T., Takahashi, S-i, Igarashi, K., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 6443-6452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557015
[Journal Article] Molecular cloning and functional characterization of a new CNC family transcription factor Nrf31999
- Author(s)
  Kobayashi, A., Itoh, E., Toki, T., Takahashi, S-i, Igarashi, K., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 6443-6452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Regulation of NF-E2 activity in erythroleukemia cell differentiation1998
- Author(s)
  Nagai, T., Igarashi, K., Akasaka, J., Furuyama, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S.
- Journal Title
  
  J.Biol.Chem. 273
  
  Pages: 5358-5365
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Differential regulation of mouse coproporphyrinogen oxidase gene expression in erythroid and non-erythroid cells1998
- Author(s)
  Takahashi, S-i., Taketani, S., Akasaka, J-e., Kobayashi, A., Hayashi, N., Yamamoto, M., Nagai, T.
- Journal Title
  
  Blood 92
  
  Pages: 3436-3444
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Alternative promoters regulate transcription of the mouse GATA-2 gene.1998
- Author(s)
  Minegishi, N., Ohta, J., Suwabe, N., Nakauchi, H., Ishihara, H., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J. Biol. Chem. 273
  
  Pages: 3625-3634
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10557015
[Journal Article] Differential regulation of mouse coproporphyrinogen oxidase geneexpression in erythroid and non-erythroid cells.1998
- Author(s)
  Takahashi, S-i., Taketani, S., Akasaka, J-e., Kobayashi, A., Hayashi, N., Yamamoto, M., Nagai, T.
- Journal Title
  
  Blood 92
  
  Pages: 3436-3444
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10557015
[Journal Article] Regulation of NF-E2 activity in erythroleukemia cell differentiation1998
- Author(s)
  Nagai, T., Igarashi, K., Akasaka, J., Furuyama, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S.
- Journal Title
  
  J.Biol.Chem. 273
  
  Pages: 5358-5365
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557015
[Journal Article] Differential regulation of mouse coproporphyrinogen oxidase gene expression in erythroid and non-erythroid cells1998
- Author(s)
  Takahashi, S-i., Taketani, S., Akasaka, J-e., Kobayashi, A., Hayashi, N., Yamamoto, M., Nagai, T.
- Journal Title
  
  Blood 92
  
  Pages: 3436-3444
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557015
[Journal Article] Differential regulation of mouse coproporphyrinogen oxidase geneexpression in erythroid and non-erythroid cells.1998
- Author(s)
  Takahashi, S-i., Taketani, S., Akasaka, J-e., Kobayashi, A., Hayashi, N., Yamamoto, M., Nagai, T.
- Journal Title
  
  Blood 92
  
  Pages: 3436-3444
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Alternative promoters regulate transcription of the mouse GATA-2 gene.1998
- Author(s)
  Minegishi, N., Ohta, J., Suwabe, N., Nakauchi, H., Ishihara, H., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J. Biol. Chem. 273
  
  Pages: 3625-3634
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Alternative promoters regulate transcription of the mouse GATA-2 gene1998
- Author(s)
  Minegishi, N., Ohta, J., Suwabe, N., Nakauchi, H., Ishihara, H., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J.Biol.Chem. 273
  
  Pages: 3625-3634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10480163
[Journal Article] Regulation of NF-E2 activity in erythroleukemia cell differentiation.1998
- Author(s)
  Nagai, T., Igarashi, K., Akasaka, J., Furuyama, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S.
- Journal Title
  
  J. Biol. Chem. 273
  
  Pages: 5358-5365
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10557015
[Journal Article] Alternative promoters regulate transcription of the mouse GATA-2 gene1998
- Author(s)
  Minegishi, N., Ohta, J., Suwabe, N., Nakauchi, H., Ishihara, H., Hayashi, N., Yamamoto, M.
- Journal Title
  
  J.Biol.Chem. 273
  
  Pages: 3625-3634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10557015
[Journal Article] Regulation of NF-E2 activity in erythroleukemia cell differentiation.1998
- Author(s)
  Nagai, T., Igarashi, K., Akasaka, J., Furuyama, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S.
- Journal Title
  
  J. Biol. Chem. 273
  
  Pages: 5358-5365
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10480163

1. MINEGISHI Naoko (40271895)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. YAMAMOTO Masayuki (50166823)

# of Collaborated Projects: 7 results

# of Collaborated Products: 8 results
3. MUNAKATA Hiroshi (90111294)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. TAKETANI Shigeru (20121949)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. KOBAYASHI Akira (50292214)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
6. NAGAI Tadashi (40237483)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. FURUYAMA Kazumichi (80280874)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 小堺正史 (20004624)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. IGARASHI Kazuhiko (00250738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. YONEMURA Yutaka (20167042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Hiroshi (00115198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OKAMOT Hiroshi (60025632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAYASHI Norio 林 典夫

Research Projects

Research Products

Co-Researchers

転写因子GATA-2の造血幹細胞と白血病細胞における発見と機能

Principal Investigator

Project Period (FY)

Research Category

Research Institution

白血病細胞における転写因子GATA-2の転写調節機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Roles of heme in the regulation of gene expression and cell differentiation of erythroid cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene manipulation of heme synthetic pathway enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

白血病細胞における転写因子GATA-2発現の役割とインターフェロンの効果Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

血球分化に関与する転写因子群の解析とその造血細胞腫瘍診断への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Regulation of erythroid differentiation by trnscription factors and hemePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcription factors regulating the erytnroid and megakaryocytic cell differentiation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血球分化に関与する転写因子群の解析とその造血細胞腫瘍診断への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis of the expression profile of lineage-specific transcription factors in leukemia cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髄性プロトポルフィリン症Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髄性プロトポルフィリン症Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Structure and function of the regulatory region of the gene encoding non-specific form delta-aminolevulinate synthasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

転写因子GATA(NF‐EI)群をコ-ドする遺伝子の構造と発現調節機序の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

HAYASHI Norio 林典夫