KONNO Tasuke 今野多助

Researcher Number	00004846
Affiliation *help	1998 : Institute of Development, Aging and Cancer, Department of Pediatric Oncology Toh, 加齢医学研究所・発達病態研究分野, 前教授 1993 – 1997 : 東北大学, 加齢医学研究所, 教授 1996 : 東北大学, 加齢医学研究所, 助手 1987 – 1992 : Research Institute for Tuberculosis and Cancer, Tohoku University, 抗酸菌病研究所, 教授 1989 : 東北大学, 抗酸菌病研所, 教授 1988 : 東北大学, 抗酸菌病研究所, 教授 1986 : 東北大, 抗酸菌病研究所, 教授
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator Pediatrics / Immunology / 内科学一般
Keywords	Principal Investigator HLA不適合 / 骨髄移植 / LFA-1 / T-ALL / HLA-mismatch / 同権骨髄移植 / allogeneic BMT / NK activity / フローサイトメトリー / Bone marrow transplantation … More Except Principal Investigator HEMATOPOIETIC STEM CELLS / IgD / GM-CSF / BCR / アポトーシス / 造血幹細胞 / gp91-phox / シグナル伝達 / XSCID / レトロウイルスベクター / WASP / p47-phox / ABL / Precursor B cell line / IL-2セレプターγ鎖 / FEEDER CELL DEPENDENCY / IL-2 / acute GVHD / インテグリン / 単クローン抗体 / Integrins / X linked agammaglobulinemia / 白血球 / NK cell / JAK1,3 / K+λ産生細胞クローン / インターロイキン15 / IL-2受容体 / β-アクチン / superoxide / ワクチン / Wiskott-Aldrich症候群 / 慢性肉芽腫症 / CD34 / IgD産生細胞株 / エレクトロポレーション / シトクロム / インターロイキン2(IL-2) / エプスタイン・バ-ウィルス / knockout mice / tyrosine kinase / 末熟骨髄性白血病細胞株 / congenital agammaglobulinemia / 抗イディオ-イディオタイプ抗体 / 遺伝子診断 / 細胞内アクチン異常症 / 未熟B細胞株 / beta-actin / IMMATURE MYELOYD LEUKEMIA CELL LINE / 遺伝子導入 / Wiskott-aldrich症候群 / NK細胞 / X連鎖重症複合免疫不全症 / 神経芽細胞腫 / Neuroblastoma / GMーCSF / Signal Transduction / abl / クロ-ナル・トランスフォ-メ-ション / ロタウィルス / γc鎖 / 表面マーカー / T cell differntiation and growth / ELECTROPORATION / プレBリンパ芽球様細胞株 / 活性酸素 / 抗イディオタイプ抗体 / 好中球 / interleukin 2 (IL-2) / Epstein-Barr virus / eosinophil / ケミルミネセンス / neutrophil / gene diagnosis / C-KIT / c-kit / 保因者診断 / 無ガンマグロブリン血症 / IgD producer / CD11 / 赤血球凝集素 / Adhesion molecule / CD18 / kappa-lambda double producer / Clonal transformation / IL-2レセプターγ鎖 / チロシンキナーゼ / Bリンパ芽球様細胞株 / CGD / IL-2 RECEPTOR gamma CHAIN / βアクチン / 細胞株 / リーダー配列 / SOLUBLE FACTOR / T細胞分化増殖 / 細胞クローニング / マウス抗WASP単クローン抗体 / 免疫磁気ビーズ / 支持細胞依存性 / B cell growth factor / EBウイルス / Chronic granulomatous disease / K+入鎖産生細胞クローン / Cell line / インターロイキン2 (IL-2) / 白血球粘着不全症 / c-Kit / 先天性無ガンマグロブリン血症 / retrovirus vector / エプスタイル・バンウイルス / carrier detection / K-λダブルプロデュ-サ- / phagocyte / 伴性無ガンマグロブリン血症 / 液性因子 / interleukin-15 / 未熟骨髄性白血病細胞株 / 細胞接着分子 / gammac chain / サイトカイン / GENE TRANSFECTION / B細胞関連抗原 / サイイトカイン / IL-2 receptor / インターフェロンα / 粘着蛋白質 / 遺伝性疾患 / 好酸球 / エプスタイン-・バ-ウィルス / mouse anti-WASP monoclonal antibody / γ鎖ノックアウトマウス / 急性移植片対宿主病 / B細胞増殖因子 / cytokine / γ鎖 / κーλ鎖2重産生株 / Wiskott-Aldrich syndrome / 食細胞 / 高IgE症候群 / 白血病細胞株 / モノクローナル抗体 / ノックアウトマウス / Fcレセプタ- / bcr Less

Research Projects
(15results)
Co-Researchers
(23People)

Development of a tumor vaccine using a membrane attached form of interleukin-15Principal Investigator
- Principal Investigator
  
  MINEGISHI Masayoshi, 今野多助
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Analysis of molecular mechanism of inherited phagocyte disorders.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Function of the gene of Wiskott-Aldrich syndrome
- Principal Investigator
  
  TSUCHIYA Shigeru
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Regulatory Factors for Growth or Apoptosis of Neuroblastoma Cells and Its Therapeutic Application
- Principal Investigator
  
  MINEGISHI Masayoshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Study of mechanism of X-licombined immunodeficiency caused by mutations of the IL-2 receptor gamma chain
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
PURIFICATION OF HEMATOPOIETIC STEM CELLS BY A CD117 MONOCLONAL ANTIBODY,MTK1, IN ORDER TO TRANSFECT HUMAN GENES-A PRELIMINARY STUDY
- Principal Investigator
  
  TSUCHIYA Shigeru
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  INSTITUTE FOR DEVELOPMENT,AGING AND CANCER (IDAC) Tohoku University
小児白血病細胞におけるGATA転写因子郡の発現に関する研究Principal Investigator
- Principal Investigator
  
  今野多助
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
ESTABLISHMENT AND CHARACTERIZATION OF AN IMMATURE MYELOID CELL LINE, M-MOK, GROWN IN THE PRESENCE OF FIBROBLAST-FEEDER CELLS
- Principal Investigator
  
  TSUCHIYA Shigeru
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  RESEARCH INSTITUTE FOR TUBERCULOSIS AND CANCER, TOHOKU UNIVERSITY (RITC,TU)
In vivo infusion of anti-CD11a/LFA-1 antibody for prevention and treatment of severe GVHD in HLA-nonidentical bone marrow transplantation : Its serum concentrations and biological effects.Principal Investigator
- Principal Investigator
  
  KONNO Tasuke
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
CD11/CD18欠損白血球の1gGFcレセプタ-の発現異常とその病態との関連
- Principal Investigator
  
  SATO Tetsuo
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Abnormal Immunoglobulin in a Patient with X-Linked Agammaglobulinemia
- Principal Investigator
  
  TSUCHIYA shigeru
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
抗イデイオタイプ抗体を用いたヒトロタウィルス感染成立機序の解析
- Principal Investigator
  
  佐藤徹雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Anti-human LFA-1 monoclonal antibodies for prevention of graft failure in HLA-mismatched bone marrow transplantation.Principal Investigator
- Principal Investigator
  
  KONNO Tasuke
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Etiology of congenital agammaglobulinemia: Growth defect of precursor B lymphoblastoid cell lines and immunoglobulin gene rearrangements.
- Principal Investigator
  
  TSUCHIYA Shigeru
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  TOHOKU UNIVERSITY
Studies on Immunologic Reconstitution after HLA-haplotype Mismatched parental Marrow TransplantationPrincipal Investigator
- Principal Investigator
  
  KONNO Tasuke
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  TOHOKU UNIVERSITY

1. MASAYOSHI Minegishi (20211592)

# of Collaborated Projects : 11results

# of Collaborated Products : 0results
2. TSUCHIYA shigeru (30124605)

# of Collaborated Projects : 10results

# of Collaborated Products : 0results
3. SATO Tetsuo (90170761)

# of Collaborated Projects : 8results

# of Collaborated Products : 0results
4. MASAHIKO Terasawa (80192201)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
5. FUJIE Hiromi (60282000)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. MINEGISHI Naoko

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. SUGAMURA Kazuo (20117360)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. KASAI Noriyuki (60001947)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. ASAO Hironobu (80250744)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. OHASHI Yoshiyuki (60250825)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. KANEGASAKI Shiro (10012767)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. NUNOI Hiroyuki (50218260)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. KOMIYAMA Jun (50020798)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. KITAGAWA Seiichi (50133278)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. SENDO Fujiro (80091833)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. KOBAYASHI Kunihiko (60091451)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. 大保和之 (70250744)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 竹重公一朗 (10037450)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. 小林陽之助 (50034062)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. 洲崎健 (90134048)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. KUMAKI Satoru

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. YAMAGUTI Yosiko

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. TERASAWA Masahiko

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

KONNO Tasuke 今野 多助

Research Projects

Co-Researchers

Development of a tumor vaccine using a membrane attached form of interleukin-15Principal Investigator

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小児白血病細胞におけるGATA転写因子郡の発現に関する研究Principal Investigator

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In vivo infusion of anti-CD11a/LFA-1 antibody for prevention and treatment of severe GVHD in HLA-nonidentical bone marrow transplantation : Its serum concentrations and biological effects.Principal Investigator

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Anti-human LFA-1 monoclonal antibodies for prevention of graft failure in HLA-mismatched bone marrow transplantation.Principal Investigator

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Studies on Immunologic Reconstitution after HLA-haplotype Mismatched parental Marrow TransplantationPrincipal Investigator

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KONNO Tasuke 今野多助