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KOBAYASHI Kunihiko  小林 邦彦

ORCIDConnect your ORCID iD *help
Researcher Number 60091451
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2008: 北海道大学, その他部局, 名誉教授
2007: 北海道大学, 名誉教授
2005: 北海道大学, 大学院・医学研究科・ 酪農学園大学・酪農学部, 名誉教授, 客員教授
2005: Hokkaido University Graduate School, School of Medicine, Professor Emeritus, 大学院・医学研究科・酪農学園大学・酪農学部, 名誉教授・客員教授
2004: 北海道大学, 大学院・医学研究科, 名誉教授 … More
2000 – 2003: Hokkaido Univ.Grad.School of Med., Pro., 大学院・医学研究科, 教授
1994 – 1999: Department of Pediatrics, Hokkaido University School of Medicine, 医学部, 教授
1997: Hokkaido Univ.Fac.of Med., Pro., 歯学部, 教授
1991 – 1992: 北海道大学, 医学部, 教授
1987 – 1988: 山口大学, 医学部, 助教授
1986: 山口大, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Laboratory medicine
Except Principal Investigator
Pediatrics / Pediatrics / 内科学一般 / Laboratory medicine / General surgery
Keywords
Principal Investigator
MBP / AIE-75 / マンノース結合蛋白 / レクチン / 補体 / lectin / MASP / オステオポンチン / 母乳 / Ca結合蛋白 … More / 自己免疫 / 難治性下痢 / アッシャー症候群 / 自己抗原 / Usher症候群 / IPEX / 小児H.pylori胃炎 / 消化管免疫 / 自己抗体 / IgG抗体 / IgA_1抗体 / IgA_2抗体 / アポトーシス / Toll-like receptor / 小児H. pylori胃炎 / 急性蛋白 / α2-マクログロブリン / MBP(mannose bincling pnotein) / 急性反応性蛋白 / マンノ-ス結合蛋白 / MBP(mannose binding protein) / α_2ーmacroglbulin / mannose-binding protein / acute phase protein / complement / alpha_2-macroglobulin / α2マクログロブリン / レクチン経路 / 生体防御 / α2マクログロフリン / 補体活性化 / 感染防御 / COMPLEMENT / alpha2-MACROGLOBULIN / LECTINPATHWAY / HOST DEFENCE / カルシウム結合蛋白 / 骨粗鬆症 / リン蛋白 / Ca-結合蛋白 / Eta-1 / ELISA / SSP / リン酸蛋白 / OSTEOPONTIN / CALCIUM BINDING PROTEIN / HUMAN MILK / OSTEOMALACIA / PHOSPHOPROTEIN / Ca-結合性 / 人母乳 / 人血清 / 分子不安定性 / 血清 / osteopontin / Ca-binding / human milk / human serum / molecular fragility / 自己免疫性腸症 / 難治性下痢症 / autoimume enteropathy / intractable diarrhea / Usher syndrome / autoantigen / プロモーター / 自己免疫性 / AIE-75遺伝子 / 遺伝子発現制御 / ALE-75 / 転写因子 / Usher's syndrome / promotor / jacalin / 分泌型IgA / 免疫複合体 / 凝集IgG / γグロブリン製剤 / 凝集体IgG / gammaglobulin / affinity chromatography / IgAサブクラス / Jacalin / secretory IgA … More
Except Principal Investigator
補体活性化 / レクチン経路 / MBP / MASP / ELISA / マンノース結合レクチン / C1 / lectin pathway / complement activation / 糖鎖 / 活性酸素 / IgG / 補体 / complement / Ra-reactive factor (RaRF) / gp91-phox / p47-phox / アルギナーゼ / 抗肝アルギナーゼ自己抗体 / arginase / anti-liver arginase autoantibody / 免疫不全 / 免疫グロブリンA / IgA腎症 / immunoglobulin A / ヒトメタニューモウイルス / ウイルス分離 / 蛍光抗体間接法 / 中和抗体 / Baculovirus / F蛋白 / coronavirus NL63 / 抗体価測定 / RT-PCR / ウエスタンブロット法 / 活性酵素 / 虚血再潅流障害 / フィコリン / 塩基性蛋白 / 糖蛋白 / リウマチ / Reuhmatoid arthritis / CI / 虚弱体質 / 易感染性体質 / 遺伝子解析 / Mannan binding lectin(MBL) / Ra-reactive factor(RaRF) / 遺伝子診断 / Mannan binding protein (MBP) / Maunose binding protein (MBP) / infirmative constitution / recurrent infectious / gene analysis / mannan binding lectin (MBL) / gene diagnosis / 慢性肉芽腫症 / 好中球 / 好酸球 / βアクチン / 食細胞 / シトクロム / レトロウイルスベクター / β-アクチン / アポトーシス / 高IgE症候群 / CGD / 白血球粘着不全症 / 細胞内アクチン異常症 / 遺伝性疾患 / Chronic granulomatous disease / neutrophil / superoxide / eosinophil / beta-actin / phagocyte / 慢性肝疾患 / 自己免疫性疾患 / 自己免疫疾患 / chronic liver disease / autoimmune disease / 成人生体部分肝移植 / 肝アルギナーゼ / 自己抗体 / 生体部分肝移植 / 自己免疫性肝炎 / adult living related liver transplantation / 酸化ストレス / 動物レクチン / レクチン / mannose binding lectin / Immunodeficiency / oxidative stress / mannose-binding lectin / immunodeficiency / IgA nephropathy Less
  • Research Projects

    (18 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (36 People)
  •  Contribution of intravital functional molecules through sugar chains to the lectin pathway, and its influence to diseases

    • Principal Investigator
      TERAI Itaru
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Rakuno Gakuen University
  •  Search for factors which affect the activation of complement ; relation to inflammation and susceptibility to infection

    • Principal Investigator
      TERAI Itaru
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Health Sciences University of Hokkaido
  •  新しく発見された呼吸器感染ウイルス(ヒトメタニューモウイルス)に関する臨床的研究

    • Principal Investigator
      石黒 信久, 菊田 英明
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Hokkaido University
  •  AIE-75 gene : with special reference to the differentiation of mucosal epithelial cells and the regulation of gene expressionPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Kunihiko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Research on the correlation of mannose binding lectin (MBL) with diabetes MBLlitus and arteriosclerosis

    • Principal Investigator
      TERAI Itaru
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Health Sciences University of Hokkaido
  •  自己免疫疾患としての小児 H.pylori胃炎の解析Principal Investigator

    • Principal Investigator
      小林 邦彦
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Hokkaido University
  •  Study of a novel autoantigen related to autoimmune enteropathy with renal tubular dysfunctionPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Kunihiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Hokkaido University
  •  Assessment of adult living related liver transplantation utilizing serum anti-liver arginase autoantibody assay : a possible novel strategy prospecting its prognosis.

    • Principal Investigator
      MAFUNE Naoki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Hokkaido University
  •  Studies on human osteopontin : isolation and characterization of osteopontin in milk and serum.Principal Investigator

    • Principal Investigator
      KOBAYASHI Kunihiko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Analysis of molecular mechanism of inherited phagocyte disorders.

    • Principal Investigator
      KANEGASAKI Shiro
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Anti-Liver Arginase Autoantibody in Human Serum : A New Tool for Diagnosis of Silent Chronic Liver Disease

    • Principal Investigator
      MAFUNE Naoki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Hokkaido University
  •  A novel lectin-dependent activation pathway of complement

    • Principal Investigator
      FUJITA Teizo
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Fukushima Medical College
  •  STUDIES ON MANNOSE-BINDING-PROTEIN (MBP) ; WITH SPECIAL REFERENCE TO COMPLEMENT ACTIVATION AND REGULATION,AND ITS DEPOSITION IN RENAL TISSUESPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Kunihiko
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  STUDIES ON CALCIUM BINDING PROTEIN,OSTEOPONTIN,ITS DIAGNOSTIC AND THERAPEUTIC APPLICATION FOR BONE DISORDERS.Principal Investigator

    • Principal Investigator
      KOBAYASHI Kunihiko
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Development of a rapid diagnosis system for the recurrent infectious constitutions.

    • Principal Investigator
      MATUURA Nobuo
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      Kitasato University
  •  A novel lectin-dependent activation pathway of complement

    • Principal Investigator
      FUJITA Teizo
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Fukushima Medical College
  •  Human serum mannose-binding protein: its function and a possible application to the clinical use.Principal Investigator

    • Principal Investigator
      KOBAYASHI Kunihiko
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Hokkaido University
  •  Development of a simple procedure for the isolation of secretory IgA by lectin affinity chromatography and its clinical application.Principal Investigator

    • Principal Investigator
      KOBAYASHI Kunihiko
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Yamaguchi University School of Medicine

All 2006

All Journal Article

  • [Journal Article] Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectin (MBL)2006

    • Author(s)
      Itaru Terai, Kunihiko Kobayashi, Jean-Pierre Vaerman, Naoki Mafune
    • Journal Title

      J Immunol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591048
  • [Journal Article] Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectin(MBL)2006

    • Author(s)
      Itaru Terai, Kunihiko Kobayashi, Jean-Pierre Vaerman, Naoki Mafune
    • Journal Title

      J Immunol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591048
  • 1.  MAFUNE Naoki (70241304)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 2 results
  • 2.  TERAI Itaru (40337043)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  FUJITA Teizo (20134223)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  MIZUOCHI Tsuguo (90133149)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  MATSUSHITA Misao (00165812)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  石黒 信久 (40168216)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  EZEKOWITZ Alan
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KOBAYASHI Ichiro
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  KUBOTA Mitsuru
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  リード ケネス
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  REID Kenneth b m
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  CHIBA Hitoshi (70197622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MATUURA Nobuo (50002332)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TAKAYAMA Yoshinaga (90245407)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TAKAGAKI Yotaro (50281324)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TAKADA Fumio (90206764)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  OGUCHI Kouki (30133292)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KANEGASAKI Shiro (10012767)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NUNOI Hiroyuki (50218260)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KOMIYAMA Jun (50020798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KITAGAWA Seiichi (50133278)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SENDO Fujiro (80091833)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  TODO Satoru (60136463)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  SASAKI Satoshi (70312345)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  OKANO Motohiko (50261300)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  KAWAMURA Nobuaki (90301879)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  KONDOH Hozumi (70195907)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  菊田 英明 (30271654)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  海老原 敬 (20374407)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  今野 多助 (00004846)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  竹重 公一朗 (10037450)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  小林 陽之助 (50034062)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  内田 正志 (40168703)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  ターナー マルコム
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  TURNER Malcolm w
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  エゼユビッツ アラン
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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