KOBAYASHI Kunihiko 小林邦彦

Researcher Number	60091451
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Affiliation (based on the past Project Information) *help	2008 : 北海道大学, その他部局, 名誉教授 2007 : 北海道大学, 名誉教授 2005 : 北海道大学, 大学院・医学研究科・酪農学園大学・酪農学部, 名誉教授, 客員教授 2005 : Hokkaido University Graduate School, School of Medicine, Professor Emeritus, 大学院・医学研究科・酪農学園大学・酪農学部, 名誉教授・客員教授 2004 : 北海道大学, 大学院・医学研究科, 名誉教授 … More
Review Section/Research Field	Principal Investigator Pediatrics / Laboratory medicine Except Principal Investigator Pediatrics / Pediatrics / General surgery / 内科学一般 / Laboratory medicine
Keywords	Principal Investigator AIE-75 / MBP / Usher症候群 / 難治性下痢 / 母乳 / IPEX / 補体 / 自己抗原 / MASP / オステオポンチン … More Except Principal Investigator レクチン経路 / MASP / ELISA / MBP / 補体活性化 / lectin pathway / complement activation / C1 / マンノース結合レクチン / アルギナーゼ / complement / 糖鎖 / IgG / 補体 / 活性酸素 / 免疫不全 / gp91-phox / immunoglobulin A / 免疫グロブリンA / 抗肝アルギナーゼ自己抗体 / arginase / anti-liver arginase autoantibody / IgA腎症 / p47-phox / Ra-reactive factor (RaRF) / 活性酵素 / リウマチ / 塩基性蛋白 / adult living related liver transplantation / Reuhmatoid arthritis / Mannan binding protein (MBP) / RT-PCR / ヒトメタニューモウイルス / β-アクチン / superoxide / 自己免疫性疾患 / 慢性肉芽腫症 / 生体部分肝移植 / Ra-reactive factor(RaRF) / 虚弱体質 / infirmative constitution / 易感染性体質 / IgA nephropathy / 動物レクチン / ウエスタンブロット法 / Baculovirus / 遺伝子診断 / Immunodeficiency / 細胞内アクチン異常症 / beta-actin / coronavirus NL63 / F蛋白 / 好中球 / eosinophil / neutrophil / gene diagnosis / 抗体価測定 / 白血球粘着不全症 / 自己免疫疾患 / 遺伝子解析 / chronic liver disease / 食細胞 / ウイルス分離 / アポトーシス / CGD / immunodeficiency / 酸化ストレス / mannose-binding lectin / gene analysis / βアクチン / mannose binding lectin / CI / recurrent infectious / Chronic granulomatous disease / oxidative stress / Maunose binding protein (MBP) / 虚血再潅流障害 / 蛍光抗体間接法 / 肝アルギナーゼ / レトロウイルスベクター / phagocyte / 自己免疫性肝炎 / 遺伝性疾患 / 好酸球 / レクチン / Mannan binding lectin(MBL) / シトクロム / 成人生体部分肝移植 / 高IgE症候群 / 糖蛋白 / フィコリン / mannan binding lectin (MBL) / 中和抗体 / 慢性肝疾患 / 自己抗体 / autoimmune disease Less

Contribution of intravital functional molecules through sugar chains to the lectin pathway, and its influence to diseases
- Principal Investigator
  
  TERAI Itaru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Rakuno Gakuen University
Search for factors which affect the activation of complement ; relation to inflammation and susceptibility to infection
- Principal Investigator
  
  TERAI Itaru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Health Sciences University of Hokkaido
新しく発見された呼吸器感染ウイルス(ヒトメタニューモウイルス)に関する臨床的研究
- Principal Investigator
  
  石黒信久, 菊田英明
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Hokkaido University
AIE-75 gene : with special reference to the differentiation of mucosal epithelial cells and the regulation of gene expressionPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kunihiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  HOKKAIDO UNIVERSITY
Research on the correlation of mannose binding lectin (MBL) with diabetes MBLlitus and arteriosclerosis
- Principal Investigator
  
  TERAI Itaru
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Health Sciences University of Hokkaido
自己免疫疾患としての小児 H.pylori胃炎の解析Principal Investigator
- Principal Investigator
  
  小林邦彦
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Hokkaido University
Study of a novel autoantigen related to autoimmune enteropathy with renal tubular dysfunctionPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kunihiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Hokkaido University
Assessment of adult living related liver transplantation utilizing serum anti-liver arginase autoantibody assay : a possible novel strategy prospecting its prognosis.
- Principal Investigator
  
  MAFUNE Naoki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Hokkaido University
Studies on human osteopontin : isolation and characterization of osteopontin in milk and serum.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kunihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  HOKKAIDO UNIVERSITY
Analysis of molecular mechanism of inherited phagocyte disorders.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Anti-Liver Arginase Autoantibody in Human Serum : A New Tool for Diagnosis of Silent Chronic Liver Disease
- Principal Investigator
  
  MAFUNE Naoki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hokkaido University
A novel lectin-dependent activation pathway of complement
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Fukushima Medical College
STUDIES ON MANNOSE-BINDING-PROTEIN (MBP) ; WITH SPECIAL REFERENCE TO COMPLEMENT ACTIVATION AND REGULATION,AND ITS DEPOSITION IN RENAL TISSUESPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kunihiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  HOKKAIDO UNIVERSITY
STUDIES ON CALCIUM BINDING PROTEIN,OSTEOPONTIN,ITS DIAGNOSTIC AND THERAPEUTIC APPLICATION FOR BONE DISORDERS.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kunihiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  HOKKAIDO UNIVERSITY
Development of a rapid diagnosis system for the recurrent infectious constitutions.
- Principal Investigator
  
  MATUURA Nobuo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kitasato University
A novel lectin-dependent activation pathway of complement
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Fukushima Medical College
Human serum mannose-binding protein: its function and a possible application to the clinical use.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kunihiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hokkaido University
Development of a simple procedure for the isolation of secretory IgA by lectin affinity chromatography and its clinical application.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kunihiko
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Yamaguchi University School of Medicine

All 2006

All Journal Article

[Journal Article] Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectin (MBL)2006
- Author(s)
  Itaru Terai, Kunihiko Kobayashi, Jean-Pierre Vaerman, Naoki Mafune
- Journal Title
  
  J Immunol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591048
[Journal Article] Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectin(MBL)2006
- Author(s)
  Itaru Terai, Kunihiko Kobayashi, Jean-Pierre Vaerman, Naoki Mafune
- Journal Title
  
  J Immunol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591048

1. MAFUNE Naoki (70241304)

# of Collaborated Projects : 8results

# of Collaborated Products : 2results
2. TERAI Itaru (40337043)

# of Collaborated Projects : 3results

# of Collaborated Products : 2results
3. FUJITA Teizo (20134223)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. MIZUOCHI Tsuguo (90133149)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
5. MATSUSHITA Misao (00165812)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. 石黒信久 (40168216)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. EZEKOWITZ Alan

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. KOBAYASHI Ichiro

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. KUBOTA Mitsuru

# of Collaborated Projects : 2results

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10. リードケネス

# of Collaborated Projects : 2results

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11. REID Kenneth b m

# of Collaborated Projects : 2results

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12. CHIBA Hitoshi (70197622)

# of Collaborated Projects : 1results

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13. MATUURA Nobuo (50002332)

# of Collaborated Projects : 1results

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14. TAKAYAMA Yoshinaga (90245407)

# of Collaborated Projects : 1results

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15. TAKAGAKI Yotaro (50281324)

# of Collaborated Projects : 1results

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16. TAKADA Fumio (90206764)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. OGUCHI Kouki (30133292)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. KANEGASAKI Shiro (10012767)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. NUNOI Hiroyuki (50218260)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. KOMIYAMA Jun (50020798)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. KITAGAWA Seiichi (50133278)

# of Collaborated Projects : 1results

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22. SENDO Fujiro (80091833)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. TODO Satoru (60136463)

# of Collaborated Projects : 1results

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24. SASAKI Satoshi (70312345)

# of Collaborated Projects : 1results

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25. OKANO Motohiko (50261300)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. KAWAMURA Nobuaki (90301879)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. KONDOH Hozumi (70195907)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
28. 菊田英明 (30271654)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
29. 海老原敬 (20374407)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
30. 今野多助 (00004846)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
31. 竹重公一朗 (10037450)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
32. 小林陽之助 (50034062)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
33. 内田正志 (40168703)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
34. ターナーマルコム

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
35. TURNER Malcolm w

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
36. エゼユビッツアラン

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

KOBAYASHI Kunihiko 小林 邦彦

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AIE-75 gene : with special reference to the differentiation of mucosal epithelial cells and the regulation of gene expressionPrincipal Investigator

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自己免疫疾患としての小児 H.pylori胃炎の解析Principal Investigator

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Study of a novel autoantigen related to autoimmune enteropathy with renal tubular dysfunctionPrincipal Investigator

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Studies on human osteopontin : isolation and characterization of osteopontin in milk and serum.Principal Investigator

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STUDIES ON MANNOSE-BINDING-PROTEIN (MBP) ; WITH SPECIAL REFERENCE TO COMPLEMENT ACTIVATION AND REGULATION,AND ITS DEPOSITION IN RENAL TISSUESPrincipal Investigator

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STUDIES ON CALCIUM BINDING PROTEIN,OSTEOPONTIN,ITS DIAGNOSTIC AND THERAPEUTIC APPLICATION FOR BONE DISORDERS.Principal Investigator

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KOBAYASHI Kunihiko 小林邦彦