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KOBAYASHI Kunihiko
小林 邦彦
Connect your ORCID iD
*help
Researcher Number
60091451
Other IDs
External Links
Affiliation (based on the past Project Information)
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2008: 北海道大学, その他部局, 名誉教授
2007: 北海道大学, 名誉教授
2005: 北海道大学, 大学院・医学研究科・ 酪農学園大学・酪農学部, 名誉教授, 客員教授
2005: Hokkaido University Graduate School, School of Medicine, Professor Emeritus, 大学院・医学研究科・酪農学園大学・酪農学部, 名誉教授・客員教授
2004: 北海道大学, 大学院・医学研究科, 名誉教授
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2000 – 2003: Hokkaido Univ.Grad.School of Med., Pro., 大学院・医学研究科, 教授
1994 – 1999: Department of Pediatrics, Hokkaido University School of Medicine, 医学部, 教授
1997: Hokkaido Univ.Fac.of Med., Pro., 歯学部, 教授
1991 – 1992: 北海道大学, 医学部, 教授
1987 – 1988: 山口大学, 医学部, 助教授
1986: 山口大, 医学部, 助教授
Less
Review Section/Research Field
Principal Investigator
Pediatrics
/
Laboratory medicine
Except Principal Investigator
Pediatrics
/
Pediatrics
/
内科学一般
/
Laboratory medicine
/
General surgery
Keywords
Principal Investigator
MBP / AIE-75 / マンノース結合蛋白 / レクチン / 補体 / lectin / MASP / オステオポンチン / 母乳 / Ca結合蛋白
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/ 自己免疫 / 難治性下痢 / アッシャー症候群 / 自己抗原 / Usher症候群 / IPEX / 小児H.pylori胃炎 / 消化管免疫 / 自己抗体 / IgG抗体 / IgA_1抗体 / IgA_2抗体 / アポトーシス / Toll-like receptor / 小児H. pylori胃炎 / 急性蛋白 / α2-マクログロブリン / MBP(mannose bincling pnotein) / 急性反応性蛋白 / マンノ-ス結合蛋白 / MBP(mannose binding protein) / α_2ーmacroglbulin / mannose-binding protein / acute phase protein / complement / alpha_2-macroglobulin / α2マクログロブリン / レクチン経路 / 生体防御 / α2マクログロフリン / 補体活性化 / 感染防御 / COMPLEMENT / alpha2-MACROGLOBULIN / LECTINPATHWAY / HOST DEFENCE / カルシウム結合蛋白 / 骨粗鬆症 / リン蛋白 / Ca-結合蛋白 / Eta-1 / ELISA / SSP / リン酸蛋白 / OSTEOPONTIN / CALCIUM BINDING PROTEIN / HUMAN MILK / OSTEOMALACIA / PHOSPHOPROTEIN / Ca-結合性 / 人母乳 / 人血清 / 分子不安定性 / 血清 / osteopontin / Ca-binding / human milk / human serum / molecular fragility / 自己免疫性腸症 / 難治性下痢症 / autoimume enteropathy / intractable diarrhea / Usher syndrome / autoantigen / プロモーター / 自己免疫性 / AIE-75遺伝子 / 遺伝子発現制御 / ALE-75 / 転写因子 / Usher's syndrome / promotor / jacalin / 分泌型IgA / 免疫複合体 / 凝集IgG / γグロブリン製剤 / 凝集体IgG / gammaglobulin / affinity chromatography / IgAサブクラス / Jacalin / secretory IgA
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More
Except Principal Investigator
補体活性化 / レクチン経路 / MBP / MASP / ELISA / マンノース結合レクチン / C1 / lectin pathway / complement activation / 糖鎖 / 活性酸素 / IgG / 補体 / complement / Ra-reactive factor (RaRF) / gp91-phox / p47-phox / アルギナーゼ / 抗肝アルギナーゼ自己抗体 / arginase / anti-liver arginase autoantibody / 免疫不全 / 免疫グロブリンA / IgA腎症 / immunoglobulin A / ヒトメタニューモウイルス / ウイルス分離 / 蛍光抗体間接法 / 中和抗体 / Baculovirus / F蛋白 / coronavirus NL63 / 抗体価測定 / RT-PCR / ウエスタンブロット法 / 活性酵素 / 虚血再潅流障害 / フィコリン / 塩基性蛋白 / 糖蛋白 / リウマチ / Reuhmatoid arthritis / CI / 虚弱体質 / 易感染性体質 / 遺伝子解析 / Mannan binding lectin(MBL) / Ra-reactive factor(RaRF) / 遺伝子診断 / Mannan binding protein (MBP) / Maunose binding protein (MBP) / infirmative constitution / recurrent infectious / gene analysis / mannan binding lectin (MBL) / gene diagnosis / 慢性肉芽腫症 / 好中球 / 好酸球 / βアクチン / 食細胞 / シトクロム / レトロウイルスベクター / β-アクチン / アポトーシス / 高IgE症候群 / CGD / 白血球粘着不全症 / 細胞内アクチン異常症 / 遺伝性疾患 / Chronic granulomatous disease / neutrophil / superoxide / eosinophil / beta-actin / phagocyte / 慢性肝疾患 / 自己免疫性疾患 / 自己免疫疾患 / chronic liver disease / autoimmune disease / 成人生体部分肝移植 / 肝アルギナーゼ / 自己抗体 / 生体部分肝移植 / 自己免疫性肝炎 / adult living related liver transplantation / 酸化ストレス / 動物レクチン / レクチン / mannose binding lectin / Immunodeficiency / oxidative stress / mannose-binding lectin / immunodeficiency / IgA nephropathy
Less
Research Projects
(
18
results)
Research Products
(
2
results)
Co-Researchers
(
36
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Contribution of intravital functional molecules through sugar chains to the lectin pathway, and its influence to diseases
Principal Investigator
TERAI Itaru
Project Period (FY)
2007 – 2008
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Pediatrics
Research Institution
Rakuno Gakuen University
Search for factors which affect the activation of complement ; relation to inflammation and susceptibility to infection
Principal Investigator
TERAI Itaru
Project Period (FY)
2004 – 2005
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Pediatrics
Research Institution
Health Sciences University of Hokkaido
新しく発見された呼吸器感染ウイルス(ヒトメタニューモウイルス)に関する臨床的研究
Principal Investigator
石黒 信久
,
菊田 英明
Project Period (FY)
2002 – 2004
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Pediatrics
Research Institution
Hokkaido University
AIE-75 gene : with special reference to the differentiation of mucosal epithelial cells and the regulation of gene expression
Principal Investigator
Principal Investigator
KOBAYASHI Kunihiko
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Pediatrics
Research Institution
HOKKAIDO UNIVERSITY
Research on the correlation of mannose binding lectin (MBL) with diabetes MBLlitus and arteriosclerosis
Principal Investigator
TERAI Itaru
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Pediatrics
Research Institution
Health Sciences University of Hokkaido
自己免疫疾患としての小児 H.pylori胃炎の解析
Principal Investigator
Principal Investigator
小林 邦彦
Project Period (FY)
2001 – 2003
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Pediatrics
Research Institution
Hokkaido University
Study of a novel autoantigen related to autoimmune enteropathy with renal tubular dysfunction
Principal Investigator
Principal Investigator
KOBAYASHI Kunihiko
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Pediatrics
Research Institution
Hokkaido University
Assessment of adult living related liver transplantation utilizing serum anti-liver arginase autoantibody assay : a possible novel strategy prospecting its prognosis.
Principal Investigator
MAFUNE Naoki
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General surgery
Research Institution
Hokkaido University
Studies on human osteopontin : isolation and characterization of osteopontin in milk and serum.
Principal Investigator
Principal Investigator
KOBAYASHI Kunihiko
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Pediatrics
Research Institution
HOKKAIDO UNIVERSITY
Analysis of molecular mechanism of inherited phagocyte disorders.
Principal Investigator
KANEGASAKI Shiro
Project Period (FY)
1996 – 1998
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
内科学一般
Research Institution
The University of Tokyo
Anti-Liver Arginase Autoantibody in Human Serum : A New Tool for Diagnosis of Silent Chronic Liver Disease
Principal Investigator
MAFUNE Naoki
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Laboratory medicine
Research Institution
Hokkaido University
A novel lectin-dependent activation pathway of complement
Principal Investigator
FUJITA Teizo
Project Period (FY)
1995
Research Category
Grant-in-Aid for international Scientific Research
Research Institution
Fukushima Medical College
STUDIES ON MANNOSE-BINDING-PROTEIN (MBP) ; WITH SPECIAL REFERENCE TO COMPLEMENT ACTIVATION AND REGULATION,AND ITS DEPOSITION IN RENAL TISSUES
Principal Investigator
Principal Investigator
KOBAYASHI Kunihiko
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Pediatrics
Research Institution
HOKKAIDO UNIVERSITY
STUDIES ON CALCIUM BINDING PROTEIN,OSTEOPONTIN,ITS DIAGNOSTIC AND THERAPEUTIC APPLICATION FOR BONE DISORDERS.
Principal Investigator
Principal Investigator
KOBAYASHI Kunihiko
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Pediatrics
Research Institution
HOKKAIDO UNIVERSITY
Development of a rapid diagnosis system for the recurrent infectious constitutions.
Principal Investigator
MATUURA Nobuo
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Pediatrics
Research Institution
Kitasato University
A novel lectin-dependent activation pathway of complement
Principal Investigator
FUJITA Teizo
Project Period (FY)
1994
Research Category
Grant-in-Aid for international Scientific Research
Research Institution
Fukushima Medical College
Human serum mannose-binding protein: its function and a possible application to the clinical use.
Principal Investigator
Principal Investigator
KOBAYASHI Kunihiko
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Laboratory medicine
Research Institution
Hokkaido University
Development of a simple procedure for the isolation of secretory IgA by lectin affinity chromatography and its clinical application.
Principal Investigator
Principal Investigator
KOBAYASHI Kunihiko
Project Period (FY)
1986 – 1988
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Pediatrics
Research Institution
Yamaguchi University School of Medicine
All
2006
All
Journal Article
[Journal Article] Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectin (MBL)
2006
Author(s)
Itaru Terai, Kunihiko Kobayashi, Jean-Pierre Vaerman, Naoki Mafune
Journal Title
J Immunol (in press)
Description
「研究成果報告書概要(欧文)」より
Data Source
KAKENHI-PROJECT-16591048
[Journal Article] Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectin(MBL)
2006
Author(s)
Itaru Terai, Kunihiko Kobayashi, Jean-Pierre Vaerman, Naoki Mafune
Journal Title
J Immunol (in press)
Description
「研究成果報告書概要(和文)」より
Data Source
KAKENHI-PROJECT-16591048
# of Projects (Dsc)
# of Projects (Asc)
1.
MAFUNE Naoki
(70241304)
# of Collaborated Projects:
8 results
# of Collaborated Products:
2 results
2.
TERAI Itaru
(40337043)
# of Collaborated Projects:
3 results
# of Collaborated Products:
2 results
3.
FUJITA Teizo
(20134223)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
4.
MIZUOCHI Tsuguo
(90133149)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
5.
MATSUSHITA Misao
(00165812)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
6.
石黒 信久
(40168216)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
EZEKOWITZ Alan
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
KOBAYASHI Ichiro
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
KUBOTA Mitsuru
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
リード ケネス
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
REID Kenneth b m
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
CHIBA Hitoshi
(70197622)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
MATUURA Nobuo
(50002332)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
TAKAYAMA Yoshinaga
(90245407)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
TAKAGAKI Yotaro
(50281324)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
TAKADA Fumio
(90206764)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
OGUCHI Kouki
(30133292)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
KANEGASAKI Shiro
(10012767)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
NUNOI Hiroyuki
(50218260)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
KOMIYAMA Jun
(50020798)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
KITAGAWA Seiichi
(50133278)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
SENDO Fujiro
(80091833)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
TODO Satoru
(60136463)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
SASAKI Satoshi
(70312345)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
OKANO Motohiko
(50261300)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
KAWAMURA Nobuaki
(90301879)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
KONDOH Hozumi
(70195907)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
菊田 英明
(30271654)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
海老原 敬
(20374407)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
今野 多助
(00004846)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
竹重 公一朗
(10037450)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
小林 陽之助
(50034062)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
内田 正志
(40168703)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
ターナー マルコム
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
TURNER Malcolm w
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
エゼユビッツ アラン
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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