MATSUSHITA Misao 松下操

Researcher Number	00165812
Affiliation *help	2014 – 2015 : 東海大学, 工学部, 教授 2011 – 2012 : 東海大学, 工学部, 教授 2003 – 2006 : 東海大, 工学部, 教授 2002 – 2006 : 東海大学, 工学部, 教授 1999 – 2002 : 福島県立医大, 医学部, 講師 … More
Research Field	Principal Investigator Immunology / Immunology Except Principal Investigator Immunology / Laboratory medicine / 神経・脳内生理学 / Integrative animal science
Keywords	Principal Investigator MASP / レクチン経路 / 補体 / MBL / sMAP / complement / lectin pathway / セリンプロテアーゼ / ficolin / C1q … More Except Principal Investigator MASP / 補体 / MBP / 自然免疫 / レクチン / レクチン経路 / C1 / complement / 分子進化 / セリンプロテアーゼ / MBL / Lectin pathway / Ficolin / IgG / ジーンターゲッティング / Lectin Pathway / フィコリン / Complement / デンマーク / PIアンカー / コレクチン / collectin / リウマチ / PCR / アミノ酸配列 / キメラ遺伝子 / MASP (MASP1, MASP2) / 免疫複合体病 / Reuhmatoid arthritis / 微生物 / mannose-binding protein / 内科 / ficolin / single channel currents / 精製 / DAF / 国際研究者交流 / Molecular Evolution / 単一イオンチャネル / イオンチャネル / 遺伝子改変マウス / 生体防御 / 小胞体 / PI-anchor / 心筋 / CI / chimeric protein / ionic channels / 単一イオンチャネル電流 / Gene targeting / スカベンジャー受容体 / lectin pathway molecular development / 損傷 / CR1 / MBP (MBL) / lectin pathway / Lectin / chimeric gene / アンノース結合蛋白 / DIC / 補体レセプター / ニワトリ血清タンパク質 / cardiac muscle / 血管 / immune complex / serine protease / PIアンカ- / complement receptor / MBP(MBL) / sarcoplasmic reticulum / 補体レセプタ- / 免疫複合体 / キメラ蛋白 / ノックアウトマウス / MASP(MASP1,MASP2) / 形態形成 / Host defeuse Less

多機能性コレクチンCL-K1はDICにおいてどのような役割を担うのかOngoing
- Principal Investigator
  
  若宮伸隆
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Asahikawa Medical College
ニワトリ血清中の新規タンパク質の構造と機能の解明Principal InvestigatorOngoing
- Principal Investigator
  
  松下操
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Tokai University
Basic study of evaluation system in vascular diseases
- Principal Investigator
  
  WAKAMIYA Nobutaka
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Asahikawa Medical College
Clarification of the origin of the classical complement pathwayPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Misao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
A novel host defense mechanism mediated by a cornplex of host defense lectin and serine protease in innate immunityPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Misao
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokai University
補体レクチン経路の自然免疫における役割と活性化機構Principal Investigator
- Principal Investigator
  
  松下操
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
補体レクチン経路の自然免疫における役割と活性化機構Principal Investigator
- Principal Investigator
  
  松下操
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Research Institution
  Fukushima Medical University
Roles of host defense lectin.s in innate immunity
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  UNIVERCTTY
Studies on a nocal sevine protease and the activation mechanism of the lectin complement pathwayPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Misao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  TOKAI UNIVERSITY
  Fukushima Medical University
Molecular basis of complement activation by ficolins throu the lectin pathsay
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Fukushima Medical University School of Medicine
Studies on the functions of serine proteases and a novel-protein with low molecular size which are involved in the lectin complete pathwayPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Misao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Fukushima Medical University
Elucidation of activation mechanism of the lectin complement pathwayPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Misao
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Fukushima Medical University
A novel lectin-dependent activation pathway of complement
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Fukushima Medical College
マンノース結合蛋白による補体活性化における制御機構Principal Investigator
- Principal Investigator
  
  松下操
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Fukushima Medical University
A novel lectin-dependent activation pathway of complement
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Fukushima Medical College
A NOVEL LECTIN-DEPENDENT ACTIVATION PATHWAY OF COMPLEMENT
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  FUKUSHIMA MEDICAL COLLEGE
Mechanism of comploment activation by MBPPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Misao
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Fukushima Medical College
Modification mechanisms of single ionic channel currents from cardiac sarcoplasmic reticulum and mitochondria by physiologically active substances.
- Principal Investigator
  
  UEHARA Akira
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Fukuoka University
Production of chimeric protein to scavenge immune complexes
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Fukushima Medical College

All 2015 2014 2012 2007 2006 2004 2002

All Journal Article Presentation Book

[Book] The ficolin family : an overview In "Collagen-related lectins in innate immunity"2007
- Author(s)
  Matsushita M.
- Publisher
  Research Signpost(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590442
[Journal Article] CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis2015
- Author(s)
  Murayama A.M, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi H-H, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y
- Journal Title
  
  Nature Communications
  
  Volume : 6 Pages : 8483
- Publisher
  Nature Publishing Group
- Year and Date
  2015-09-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26450448, KAKENHI-PROJECT-26293094
[Journal Article] New insights into the role of ficolins in the lectin pathway of innate immunity.2015
- Author(s)
  Endo Y, Matsushita M, Fujita T
- Journal Title
  
  International Review of Cell and Molecular Biology
  
  Volume : 316 Pages : 49-110
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26450448, KAKENHI-PROJECT-25460596
[Journal Article] No Strong Relationship Between Components of the Lectin Pathway of Complement and Susceptibility to Pulmonary Tuberculosis.2015
- Author(s)
  Chalmers JD, Matsushita M, Kilpatrick DC, Hill AT
- Journal Title
  
  Inflammation
  
  Volume : 38 Pages : 1731-1737
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450448
[Journal Article] CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis2015
- Author(s)
  Murayama A.M, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi H-H, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y
- Journal Title
  
  Nature Communications
  
  Volume : 6 Pages : 8483
- Publisher
  Nature Publishing Group
- Year and Date
  2015-09-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26450448, KAKENHI-PROJECT-26293094
[Journal Article] New insights into the role of ficolins in the lectin pathway of innate immunity.2015
- Author(s)
  Endo Y, Matsushita M, Fujita T
- Journal Title
  
  International Review of Cell and Molecular Biology
  
  Volume : 316 Pages : 49-110
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26450448, KAKENHI-PROJECT-25460596
[Journal Article] No Strong Relationship Between Components of the Lectin Pathway of Complement and Susceptibility to Pulmonary Tuberculosis.2015
- Author(s)
  Chalmers JD, Matsushita M, Kilpatrick DC, Hill AT
- Journal Title
  
  Inflammation
  
  Volume : 38 Pages : 1731-1737
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450448
[Journal Article] Serum ficolin-2 in hospitalised patients with community-acquired pneumonia.2014
- Author(s)
  Chalmers JD, Fleming GB, Rutherford J, Matsushita M, Kilpatrick DC, Hill AT
- Journal Title
  
  Inflammation
  
  Volume : 37 Pages : 1635-1641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26450448
[Journal Article] Serum ficolin-2 in hospitalised patients with community-acquired pneumonia.2014
- Author(s)
  Chalmers JD, Fleming GB, Rutherford J, Matsushita M, Kilpatrick DC, Hill AT
- Journal Title
  
  Inflammation
  
  Volume : 37 Pages : 1635-1641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26450448
[Journal Article] Guideline forHereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication2012
- Author(s)
  Horiuchi T, Ohi H, Ohsawa I, Fujita T,Matsushita M, Okada N, Seya T,Yamamoto T, Endo Y, Hatanaka M,Wakamiya N, Mizuno M, Nakao M, OkadaH, Tsukamoto H, Matsumoto M, Inoue N,Nonaka M, Kinoshita T.
- Journal Title
  
  Allergol Int
  
  Volume : 61(4) Pages : 559-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390113, KAKENHI-PROJECT-22570144, KAKENHI-PROJECT-22659081, KAKENHI-PROJECT-24370094
[Journal Article] Soluble Host-Defense Lectins2012
- Author(s)
  Matsushita M, Kilpatrick D. C., Lee B. L, and Wakamiya N.
- Journal Title
  
  Journal of Biomedicine and Biotechnology
- Data Source
  KAKENHI-PROJECT-22390113
[Journal Article] The ficolin family : an overview.2007
- Author(s)
  Matsushita, M.
- Journal Title
  
  Collagen-related lectins in innate immunity Research Signpost (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590442
[Journal Article] Significance of MBL in infectious diseases (in Japanese)2006
- Author(s)
  Matsushita, M.
- Journal Title
  
  Kansensyo 36
  
  Pages : 27-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590442
[Journal Article] Lectin complement pathway in innate immunity (in Japanese)2006
- Author(s)
  Matsushita, M.
- Journal Title
  
  Kaiyo 45
  
  Pages : 177-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590442
[Journal Article] 自然免疫における補体レクチン経路2006
- Author(s)
  松下操
- Journal Title
  
  海洋 45
  
  Pages : 177-184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590442
[Journal Article] 感染症におけるMBLの意義2006
- Author(s)
  松下操
- Journal Title
  
  感染症 36
  
  Pages : 27-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590442
[Journal Article] Origin of the classical complement pathway lamprey orthologue of mammalian Clq acts as a lectin2004
- Author(s)
  Matsushita, M.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 101
  
  Pages : 10127-10131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590441
[Journal Article] Origin of the classical complement pathway : Lamprey orthologue of mammalian C1q acts as a lectin.2004
- Author(s)
  Matsushita, M. et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101
  
  Pages : 10127-10131
- Data Source
  KAKENHI-PROJECT-13143204
[Journal Article] Origin of the classical complement pathway : lamprey orthologue of mammalian C1q acts as a lectin2004
- Author(s)
  Matsushita M.
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 101
  
  Pages : 10127-10131
- Data Source
  KAKENHI-PROJECT-15590441
[Journal Article] Origin of the classical complement pathway : Lamprey orthologue of mammalian Clq acts as a lectin.2004
- Author(s)
  Matsushita, M. et al.
- Journal Title
  
  Pro. Nat. Acad. Sci. USA. 101
  
  Pages : 10127-10131
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13143204
[Journal Article] Activation of the lectin complement pathway by H-ficolin. (Hakata antigen).2002
- Author(s)
  Matsushita, M. et al.
- Journal Title
  
  J. Immunol. 168
  
  Pages : 3502-3506
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13143204
[Journal Article] Activation of the lectin complement pathway by H-ficolin (Hakata antigen).2002
- Author(s)
  Matsushita, M. et al.
- Journal Title
  
  J. Immunol. 168
  
  Pages : 3502-3506
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13143204
[Journal Article] The role of ficolins in innate immunity.2002
- Author(s)
  Matsushita, M. et al.
- Journal Title
  
  Immunobiology. 205
  
  Pages : 490-497
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13143204
[Presentation] EW135, a chicken egg white protein with group B scavenger cycteine-rich domains, binds to Staphylococcus aureus and Protein A2015
- Author(s)
  Yoo W, Tateishi K, Matsushita M
- Organizer
  5th European Veterinary Immunology Workshop
- Place of Presentation
  ウイーン（オーストリア）
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450448
[Presentation] EW135, a chicken egg white protein with group B scavenger cycteine-rich domains, binds to Staphylococcus aureus and Protein A2015
- Author(s)
  Yoo W, Tateishi K, Matsushita M
- Organizer
  5th European Veterinary Immunology Workshop
- Place of Presentation
  ウイーン（オーストリア）
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450448

1. FUJITA Teizo (20134223)

# of Collaborated Projects : 6results

# of Collaborated Products : 1results
2. TAKAHASHI Minoru (00285024)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
3. ENDO Yuichi (20117427)

# of Collaborated Projects : 3results

# of Collaborated Products : 3results
4. MIZUOCHI Tsuguo (90133149)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
5. SATOH Tetsuo (00235368)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. KOBAYASHI Kunihiko (60091451)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. WAKAMIYA Nobutaka (20210867)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
8. OHTANI Katsuki (90396367)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. SUZUKI Ysuhiko (90206540)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. MORI Kenichiro (70610236)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. MATSUDA Yasuyuki (10532252)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
12. EZEKOWITZ Alan

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
13. リードケネス

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
14. REID Kenneth b m

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
15. YOSHIDA Itsuro (20041816)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. KURAYA Mikio (60234548)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. NAKAUCHI Hiromitsu (40175485)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. UEHARA Akira (60140745)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. OGAWA Kouichi (60078780)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. OGATA Shigenori (30131816)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. IMANAGA Ittusei (40078613)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. FUJITA Takashi (80254001)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. IWAKI Daisuke (10315492)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. NAKATA Munehiro (00266371)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. NAAKMURA Takanori (70183887)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. AZUMI Kaoru (90221720)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. 本村亘 (70374791)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
28. 浅沼秀樹 (40333570)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
29. ターナーマルコム

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
30. TURNER Malcolm w

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
31. エゼユビッツアラン

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
32. 西城忍

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
33. 岩倉洋一郎

# of Collaborated Projects : 0results

# of Collaborated Products : 2results

MATSUSHITA Misao 松下 操

Research Projects

Research Products

Co-Researchers

多機能性コレクチンCL-K1はDICにおいてどのような役割を担うのかOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ニワトリ血清中の新規タンパク質の構造と機能の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the origin of the classical complement pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel host defense mechanism mediated by a cornplex of host defense lectin and serine protease in innate immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

補体レクチン経路の自然免疫における役割と活性化機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

補体レクチン経路の自然免疫における役割と活性化機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Studies on a nocal sevine protease and the activation mechanism of the lectin complement pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the functions of serine proteases and a novel-protein with low molecular size which are involved in the lectin complete pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of activation mechanism of the lectin complement pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

マンノース結合蛋白による補体活性化における制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MATSUSHITA Misao 松下操