YAMASHITA Hiroshi 山下博

Researcher Number	00030841
Affiliation *help	2016 – 2018 : 産業医科大学, 名誉教授、学長等, 名誉教授 2002 : Kyushu Nutrition Welfare University, Professor, 食物栄養学部, 教授 2000 – 2001 : 産業医科大学, 医学部, 名誉教授 1986 – 2000 : University of Occupational and Environmental Health, School of Medicine Prof., 医学部, 教授 1987 – 1989 : 産業医科大学, 教授
Review Section/Research Field	Principal Investigator Environmental physiology (including Physical medicine and Nutritional physiology) / 環境生理学(含体力医学･栄養生理学) Except Principal Investigator General physiology / Biological Sciences / Neurophysiology and muscle physiology / 環境生理学(含体力医学･栄養生理学) / Environmental physiology (including Physical medicine and Nutritional physiology) / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator バゾプレッシン / 視床下部 / オキシトシン / 視索上核 / 遺伝性多飲マウス / 室傍核 / カルシウム画像解析 / バゾプレシン / vasopressin / PACAP … More Except Principal Investigator 神経内分泌 / PACAP / 体温調節 / CCK-8 / 視床下部 / adrenomedullin / アドレノメデュリン / バゾプレッシン / 自律神経 / PAMP / 視索上核 / blood-brain barrier / direction-related neuron / 内在性生理活性物質 / Caffeine / 室傍核 / AM遺伝子 / タイトジャンクション / プロポフォール / グルカゴン / 脳神経 / パッチクランプ / チトクローム / 脳内移殖 / Non-spiking neurone / 水代謝の比較生理学 / 神経移植 / Food Intake / グリア細胞 / biologically active peptide / 水分代謝の比較生理学 / ILー1 / FGF / 病態生理 / autonomic nerve / non-selective cation channels / Interferon / コルチコステロン / アドレノメデュリン遺伝子 / 認知関連ニュ-ロン / 水分代謝と体温 / GABA_B receptors / pathophysiology / ペプチド / 視床下部温度感受性ニュ-ロン / Comparative physiology / 分泌 / 飲水 / Ryanodine Ca^<2+> stores / 情報伝達 / 化学感受性ニューロン / カルシウム画像解析 / C末端アミド化 / 静脈麻酔薬 / VIP / 滲透圧調節 / 摂食代謝調節 / 受容認識 / Water metabolism / 水分代謝と循環 / 脳脊髄液 / 循環器疾患 / endothelial cells / tight junction / ニューロランシン / 血液脳関門 / circulation control / acidic fibroblast growth factor / ラジオイムノアッセイ / central nervous system / CCKー8 / Drinking / 免疫サイトカイン / transgenic animal / 神経的制御 / ノックアウト動物 / RT-PCR怯 / 降圧ペプチド / Ca^<2+> imaging / Environmental adaptation / mRNA / 松果体 / GABA_B受容体 / 酸性線維芽細胞成長因子 / 不斉合成 / 循環調節機構 / Fos蛋白 / Endogenous Neurosubstances / 飲水行動 / Ca^<2+>電流 / CCK-octapeptide / ANP / アドレノメデユリン / 循環調節 / GABA / 循環調節因子 / 進化 / インターフェロン / オキシトシン / Thermoregulation / Redox state / Prostaglandin E_2 / 化学的制御 / 脳腸ペプチド / receptor / Water balance and circulation / IL-1 / 酸化還元位 / 受容体 / Ca^<2+>画像解析 / Ryanodine感受性Ca^<2+>ストア / 非選択性陽イオンチャネル / ストレス / 情報行動 / Osmoregulation / knockout mouse / 生合成機構 / 扁桃体内側核 / 病態 / 動脈硬化 / 脳Na利尿ホルモン / Ryanodin感受性Ca^<2+>ストア / 中枢性体液調節 / アンギオテンシン / 予測制御 / AMシンポジウム / 水分代謝 / ノンスパイキングニューロン / hypothalamic neuronal histamine / cerebrospinal fluid / Fibroblast Growth Factor / neural transplantation / 脳移植 / 血管内皮細胞 / RAMP-1,-2,-3 / サイアミラル / ニューロテンシン / feedforward control / 生体内制御機構 / hypothalamic thermosensitive neuron / 生理活性ペプチド / Cytochromes / 視床下部温度ニュ-ロン / サイトカイン / Interleukins / 嗅細胞 / 本能行動 / 視床下部神経分泌ヒスタミン / ボンベシン / 脳腸ホルモン / 海馬学習関連ニュ-ロン / 視床下部視索上核 / Oxytocin / Central control of water balance / グルカブン / 蝸牛有毛細胞 / Substance P / Patch clamp / 有機酸 / Triphosphoinositide (TPI) / olfactory receptor neuron / TNF / 血管作動性ペプチド / 肝門脈IL-1βセンサ- / セロトニンEC細胞 / 視視策上核 / stress / 探索医療 / プロスタグランディンE_2 / 血圧 / 心不全 / 環境適応 / chemosensitive neuron / 化学感受性ニュ-ロン / モノクローナル抗体 / supraoptic nucleus / プロスタグランディン / 海馬方向選択ニューロン / トランスジェニック動物 / Water balance and body temperature Less

Research Projects
(17results)
Co-Researchers
(54People)

The localization and physiological role of adrenomedullin and related-peptides in the central nervous systemPrincipal Investigator
- Principal Investigator
  
  UETA Yoichi, 山下博
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Occupational and Environmental Health, Japan
Role of Cardiovascular-related Peptides in the Brain : Genetic, Molecular Biological, Morphological and Physiological Aspects.Principal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  University of Occupational and Environmental Health
The study of physiological and pathophysiological roles of adrenomedullin and related peptides.
- Principal Investigator
  
  ETO Tanenao
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Miyazaki Medical College
Molecular and Cellular Biology in Mechanism of Body Fluid Homeostasis (Analysis of Inter- and Intra-Cellular Signalling in the Neurosecretory Cells)Principal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  University of Occupational and Environmental Health
免疫サイトカイン・神経ペプチド麻酔関連薬の視床下部神経内分泌細胞への影響
- Principal Investigator
  
  井上義崇
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
Analysis of the mechanism of immune signal transduction to hypothalamic neuroendocrine cellsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  University of Occupational and Environmental Health
バゾプレッシン・オキシトシンによる生体調節機序の解明-分子生物学・形態学・薬理学及び生理学的アプローチ-Principal Investigator
- Principal Investigator
  
  山下博
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Occupational and Environmental Health, Japan
The role of water metabolism on the environmental adaptation
- Principal Investigator
  
  MORIMOTO Taketoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Kyoto Prefectural University of Medicine
Neuroendocrine and immune system in genetically polydipsic mice and development of animal model in response to environmental stressPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  University of Occupational and Environmental Health
Analysis with Ca2+ imaging and membrane potential measurement in neuroendocrine cells
- Principal Investigator
  
  SHIBUYA Izumi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  University of Occupational and Environmental Health
Role of immunocytokine on the neuroendocrine sysytemPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  University of Occupational and Environmental Health
Central mechanisms of drinking behavior in inbred polydipsic mice : molecular and physiological analysisPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Occupational and Environmental Health
Roles of Neuropeptides on Central Regulation of Water Balance and Autonomic Nervous SystemPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  University of Occupational and Environmental Health, Japan
生体調節系における脳腸ペプチドの役割
- Principal Investigator
  
  KANNO Tomio
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  General physiology
- Research Institution
  Hokkaido University
Neuronal and chemical control of emotical behavior
- Principal Investigator
  
  OOMURA Yutaka
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyushu University
New Endogenous Substances Controlling Different Homeostatic Functions.
- Principal Investigator
  
  HORI Tetsuro
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  Saga Medical School
Paracrine secretion; its function, morphology and concept
- Principal Investigator
  
  KANNO Tomio
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  General physiology
- Research Institution
  Hokkaido University

1. UETA Yoichi (10232745)

# of Collaborated Projects : 10results

# of Collaborated Products : 0results
2. SHIBUYA Izumi (50162649)

# of Collaborated Projects : 7results

# of Collaborated Products : 0results
3. INENAGA Kiyotoshi (90131903)

# of Collaborated Projects : 6results

# of Collaborated Products : 0results
4. KANNAN Hiroshi (00049058)

# of Collaborated Projects : 5results

# of Collaborated Products : 0results
5. KAWATA Mitsuhiro (60112512)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
6. HORI Tetsuro (00022814)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
7. KANNO Tomio (50009982)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. OTSUKA Masanori (60013801)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. HISADA Mituhiko (70000768)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. YANAIHARA Noboru (80046250)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. KABASHIMA Narutoshi (80279322)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
12. KANGAWA Kenji (00112417)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
13. OOMURA Yutaka (30019517)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
14. DREIFUSS J.J

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
15. KOIZUMI Kiyo

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
16. NAGATOMO Toshihisa (50258604)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. MORIMOTO Taketoshi (30079694)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. TAKEI Yoshio (10129249)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. SHIRAKI Keizo (00035453)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. YAMASHITA Uki (00028680)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. ETO Tanenao (10038854)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. MINAMINO Naoto (50124839)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. NAKAO Kazuwa (00172263)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. FUJITA Toshiro (10114125)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. KITAMURA Kazuo (50204912)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. NOGUCHI Jun (00330978)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. SERINO Ryota (00309957)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
28. YANAGISAWA Keiji (20064363)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
29. ONODA Norihiko (60106903)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
30. ONO Taketoshi (50019577)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
31. NIIJIMA Akira (20018287)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
32. NAGASAKA Tetsuo (80023646)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
33. NAKAYAMA Teruo (80022763)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
34. SANO Yutaka (00079683)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
35. OSAKA Toshimasa (30152101)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
36. 井上義崇 (60279346)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
37. 重松昭生 (30037428)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
38. 小林繁 (00018342)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
39. 細見弘 (70030864)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
40. 根来英雄 (90018903)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
41. 大磯ユタカ (40203707)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
42. TRIBOLLET E.

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
43. KOIZUMI K.

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
44. PFAFF D.W.

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
45. KOIZUMI K

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
46. PFAFF D.W

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
47. MASSAKO KADE

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
48. KIYOMI KOIZU

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
49. KOIZUMI Kiyomi

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
50. KADEKARO Masako

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
51. KADEKARO Mas

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
52. TRIBOLLET El

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
53. KOW Lee Ming

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
54. VALE Wylie

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

YAMASHITA Hiroshi 山下 博

Research Projects

Co-Researchers

The localization and physiological role of adrenomedullin and related-peptides in the central nervous systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Cardiovascular-related Peptides in the Brain : Genetic, Molecular Biological, Morphological and Physiological Aspects.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular and Cellular Biology in Mechanism of Body Fluid Homeostasis (Analysis of Inter- and Intra-Cellular Signalling in the Neurosecretory Cells)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanism of immune signal transduction to hypothalamic neuroendocrine cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

バゾプレッシン・オキシトシンによる生体調節機序の解明-分子生物学・形態学・薬理学及び生理学的アプローチ-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Neuroendocrine and immune system in genetically polydipsic mice and development of animal model in response to environmental stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of immunocytokine on the neuroendocrine sysytemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Central mechanisms of drinking behavior in inbred polydipsic mice : molecular and physiological analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Roles of Neuropeptides on Central Regulation of Water Balance and Autonomic Nervous SystemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

YAMASHITA Hiroshi 山下博