Dohi Toshihiro 土肥敏博

… Alternative Names

Researcher Number	00034182
Other IDs
Affiliation (Current)	2021: 広島文化学園大学, 看護学部, 教授 2021: 広島大学, 医系科学研究科(歯), 名誉教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 広島文化学園大学, 看護学部, 教授 2015: 日本薬科大学, 薬学部, 教授 2011 – 2012: 日本薬科大学, 薬学部, 教授 2008: Hiroshima University, 大学院・医歯薬学総合研究科, 名誉教授 2007 – 2008: 広島大学, 医歯薬学総合研究科, 教授 … More
Review Section/Research Field	Principal Investigator Functional basic dentistry / Functional basic dentistry Except Principal Investigator Functional basic dentistry / Functional basic dentistry / Conservative dentistry / Neurochemistry/Neuropharmacology / Pain science / Orthodontic/Pediatric dentistry / Conservative dentistry / Surgical dentistry … More
Keywords	Principal Investigator PAF / 血小板活性化因子 / カルシウム / 顎下腺 / アセチルコリン / Calcium / Platelet-activating factor / Acetylcholine / Acetyltransferase / Submandibular gland … More Except Principal Investigator 血小板活性化因子(PAF) / 神経伝達物質 / トランスポーター / FK506 / 好中球 / 難治性疼痛 / 神経障害性疼痛 / 鎮痛 / アロディニア / cyclic ADP-ribose / cyclic AMP / 副腎クロマフィン細胞 / がん性疼痛 / ドパミン / ドパミントランスポーター / リアノジン受容体チャネル / FK506-binding protein(FKBP) / FK506-binding protein (FKBP) / NMDA / 正向反射 / GABA / 顎下腺細胞 / がん細胞培養上清 / 新規鎮痛薬 / 薬理学 / 鎮痛作用 / ニコチン / 転写 / ADHD / モルヒネ / 疼痛 / Chemotaxis / PACAP / オピオイド / アセチルコリン / ADP-ribosyl cyclase / ryanodine receptor channel / 全身麻酔 / GABA神経 / suramin / nociceptin / allodynia / Ca^<2+>-induced Ca^<2+> release / anti-FKBP12 / 12.6 antibody / Ca^<2+>動員作用 / Gabaculine / NO-711 / 全身麻酔作用 / Behavioral pharmacology / ノルエピネフリン / Neurotransmitter / Dopamine / Cyclic ADP-ribose (cADPR) / CD38 / 歯学 / LPCAT2 / 高齢者 / 血小板活性化因子（PAF） / 細胞内カルシウム / シナプス伝達 / コリン作動性神経 / 合成局所麻酔薬 / 取込み阻害 / COS細胞遺伝子導入発現系 / コカイン / ドーパミントランスポーター / GABAトランスポーター / 歯肉溝滲出液 / 歯周病 / protein kinase C / 細胞外カルシウム流入 / 受容体Ca^<2+>チャンネル(ROC)機構 / Ca^<2+>流入促進物質(CIF) / ROC機構阻害薬 / 活性調節機構 / インターロイキン-1 / Ca^<2+>チャンネル / Ca^<2+>流入阻害タンパク質 / 細胞死 / 細胞内情報伝達系 / 新規内因性鎮痛物質 / オピオイド受容体 / 内因性鎮痛ペプチド / がん細胞 / がん性疼痛治療薬 / nicotine / dopamine / transpoter / transcription / pain / ノルアドレナリン / 内分泌撹乱物質 / 発達 / ドパミン神経 / 保存修復学 / 歯痛 / 歯髄 / 癌性疼痛 / PAF 阻害薬 / 下降性疼痛抑制系 / PAF阻害薬 / がん生存率 / モルヒネ作用増強 / 副作用軽減 / グリシントランスポーター / グリシントランスポ一ター阻害薬 / 血小板性化因子(PAF) / PAF受容体拮抗薬 / グリシン受容体 / 下降性痛覚抑制系 / グリシントランスポーター阻害薬 / 歯科薬理学 / 新規内因性鎮痛関連物質 / 12ーhydroxyeicosatetraenoic acid / 白血球遊走 / 12-hydroxyeicosatetraenoic acid / 12-Hydroxyeicosatetraenoic acid / 副腎髄質 / オピオイドペプチド / 受容体 / クロマフィン細胞 / メチオニン・エンケファリン / カテコールアミン / ダイノルフィン / ストレス / ardenal medulla / opioid / receptor / chromaffin cell / methionin-enkephalin / catecholamine / dynorphin / Ca^<2+>動員 / Ca^<2+>-induced Ca^<2+>release / リアノジン受容体チャンネル / Ca^<2+>ーinduced Ca^<2+>release / ADPーribosyl cyclase / FK506ーbinding protein(FKBP) / CaィイD12+ィエD1 mobilization / CaィイD12+ィエD1 -induced CaィイD12+ィエD1 release / GABA_A受容体 / 興奮性アミノ酸受容体 / ムシモール / ビククリン / L-アリルグリシン / カイニン酸 / 全身麻酔薬 / プロポフォール / マイクロダイアリシス / GABAィイD2AィエD2 receptors / Excitatory amino acid receptors / Muscimol / Bicuculline / L-Allyglycine / N-methyl-D-aspartate / Kainic aci / General anesthetics / プロスタグランジン / ATP受容体 / α,β-methylene ATP / α,β-methyleneATP / 痛覚過敏 / マウス / P2プリン受容体 / prostaglandin / ATP receptor / α, β-methylene ATP / morphine / cyclic ADP-ribose(cADPE) / 細胞内Ca^<2+>動員作用 / cADPR阻害薬,8BR-cADPR / FK506結合タンパク質(FKBP) / リアノジン受容体 / 唾液腺細胞 / 容量性Ca^<2+>流入 / cyclic ADP-ribose (cADPR) / Ca^<2+> mobilization / cADPR antagonist, 8Br-cADPR / 行動薬理学 / 脳マイクロダイアリシス法 / グルタミン酸 / ケタミン / GABAculine / 脳内GABA濃度 / 内因性GABA / General anesthesia / microdialysis / Glutamate / Ketamine / 選択的スプライシング / 抗うつ薬 / norepinephrine / transporter / neurotransmitter / alternative splicing / antidipressant / 注意欠陥多動性障害 / 神経伝達物質トランスポーター / 3'非翻訳領域 / VNTR多型 / DAT3'UTR / DAT3'-UTR / VNTR / Dopamine Transporter / Attention Deficit Hyperactivity Disorder (ADHD) / Neurotransmitter Transporter / 3'-untranslated region (UTR) / VNTR polymorphism / ヒト好中球 / FK506-結合蛋白質(FKBP) / ヌクレオシドトランスポーター / 好中球遊走 / Cyclic ADP-ribose(cADPR) / 細胞内Ca^<2+>濃度([Ca^<2+>]i) / human neutrophils / Ca^<2+>-mobilization / FK5O6-binding protein (FKBP) / Ryanodine receptor channel / Neucleotide transpoter / 遺伝子 / 環境 / 脳・神経 / 注意欠陥多動性障害(ADHD) / 内分泌攪乱物質 / 環境ホルモン / プロモーター / Gene / Environment / Dentistry / Brain / Neuron / Pharmacology / Transporter / 神経因性疼痛 / ヌクレオシドトランスポーター(NT) / NT阻害薬 / 抗侵害作用 / 抗炎症作用 / 炎症性疼痛 / 環状ADPリボース / 痛覚伝達制御 / 抗アロディニア作用 / 鎮痛薬 / 抗炎症薬 / 環状ADP-リポース / neuropathic pain / cyclic ADP-ribase (cADPR) / descending inhibitory neuron / glycine receptor α3 (GlyRα3) / spinal pain sensation / neucleoside transpoter (NT) / NT inhibitor / 不動化 / α_2-アドレナリン受容体作動薬 / オピオイド受容体作動薬 / グリシン取り込み阻害薬 / α2-アドレナリン受容体作動薬 / 全身麻痺作用 / General Anesthesia / μ-Opioid receptor agonist / α_2-Adrenergic receptor agonist / Glycine transporter inhibitor / Unconsciousness / Immobility / Analgesia / ムチン / 顎下腺 / カルシウム / イヌ / ムチン分泌 / 単離腺房細胞 / α受容体 / β受容体 / カルシウムcAMP / 腺房細胞 / Mucin / Submandibular gland / Ca^<2+> / Acetylcholine / Norepinephirne / Dog / マイクロRNA / Let-7b-5p / TLR7 / miRNA / 誘導型PAF合成酵素（LPCAT2) / 疼痛緩和 / Let-7b / TLR－７ / 介護予防 / BDNF / IGF-1 / エクササイズ / 唾液 / 運動 / BDNF（脳由来神経栄養因子） / IGF-1（インスリン様成長因子） / 老年看護学 / PAF合成酵素（LPCAT2） / 疼痛の発症と維持 / LPCAT2阻害薬 / 鎮痛薬開発 / PAF合成酵素 / PAF / 難治性皮膚潰瘍 / 褥瘡 / TRPV3 / 褥瘡治療薬 / 予防法 / 難治性創傷 / 誘導型PAF合成酵素 (LPCAT2) / LPCAT2阻害 Less

難治性疼痛治療薬，血小板活性化因子合成酵素阻害薬の疼痛治療戦略と歯科領域への応用Ongoing
- Principal Investigator
  
  本山直世
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
高齢者における皮膚潰瘍・褥瘡に対する効果的治療法・予防法の開発Ongoing
- Principal Investigator
  
  讃井真理
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Hiroshima Bunka Gakuen University
Novel pain treatment strategy-Identification of novel analgesic peptide produced by cancer cells and elucidation of analgesic mechanism
- Principal Investigator
  
  MORITA KATSUYA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pain science
- Research Institution
  Hiroshima Bunka Gakuen University
Care prevention: Evaluation of motor function and effective intervention strategy based on salivary neurotrophic factor
- Principal Investigator
  
  Sanai Mari
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gerontological nursing
- Research Institution
  Hiroshima Bunka Gakuen University
Role of spinal LPCAT2, an inducible PAF synthesis enzyme on development and maintenance of painful peripheral neuropathy models in mice
- Principal Investigator
  
  MOTOYAMA NAOYO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Hiroshima University
Extracellular miRNA causes neuropathic pain via spinal TLR7 in peripheral nerve injury.
- Principal Investigator
  
  Morita Kastuya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pain science
- Research Institution
  Hiroshima Bunka Gakuen University
Development of mechanism-based novel medicaments to pain in advanced cancer
- Principal Investigator
  
  MORITA Katsuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Identification of tumor-cell producing novel endogenous analgesic substance
- Principal Investigator
  
  MORITA Katsuya
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Potential pain-releasing action of PAF antagonists in neuropathic pain animal models and the mechanisms of action
- Principal Investigator
  
  MOTOYAMA Naoyo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Hiroshima University
Nicotinic regulation of the neurotransmitter transpoters and its relevance to analgesia
- Principal Investigator
  
  OOYAMA Kazumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Effects of endocrine disorders on developing dopaminergic system in brain
- Principal Investigator
  
  MITSUHATA Chieko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Hiroshima University
アロディニア発症の分子機構とその治療薬の開発に関する研究Principal Investigator
- Principal Investigator
  
  土肥敏博
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Evidence of a role for cyclic ADP-ribose in pain transduction in spinal cord
- Principal Investigator
  
  MORITA Katsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Clarification of mechanisms of analgesia and immobility induced by general anesthesia, and exploration of new anesthetic methods
- Principal Investigator
  
  IRIFUNE Masahiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
機械的刺激に対する細胞応答を利用した口腔組織の健康法に関する研究Principal Investigator
- Principal Investigator
  
  土肥敏博
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Influence of environment on the dopamine transporter gene expression during development
- Principal Investigator
  
  KITAYAMA Shigeo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  OKAYAMA UNIVERSITY
The role of Platelet-Activating Factor (PAF) on the mechanisms of development of neuropathic pain. And its regulationPrincipal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Evidence of a role for cyclic ADP-ribose in calcium signaling and migration in human neutrophils
- Principal Investigator
  
  MORITA Katsuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Regulation of the expression of dopamine transporter through 3'-untranslated region of mRNA
- Principal Investigator
  
  MITSUHAHA Chieko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  HIROSHIMA UNIVERSITY
Regulation of dopamine transporter function and its role in neuronal diseases - Regulation by arachidonic acid.Principal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Mechanisms of cyclic ADP-ribose-induced Ca^<2+> mobilization and its physiological role
- Principal Investigator
  
  MORITA Katsuya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
The Role of GABA and Glutamate Neurons in General Anesthetic Action
- Principal Investigator
  
  KAWAHARA Michio, 入船正浩
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Regulated expression and functional modulation of norepinephrine transporter by isoform interaction
- Principal Investigator
  
  KITAYAMA Shigeo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  OKAYAMA UNIVERSITY
  Hiroshima University
Development of the inhibitor for store-operated Ca^<2+> channel and its apply for treatment of diseases.Principal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Mechanisms of receptor-operated Ca^<2+> entry-Molecular structures and the function of store-operated Ca^<2+>entry and its blockers.Principal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
The Mechanism of Allodynia and the Role of Opioids as Regulating Factors
- Principal Investigator
  
  IMAI Yasuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  University of Tokushima
  Hiroshima University
口腔内機能不全と脳の老化-脳内オピオイドの役割-Principal Investigator
- Principal Investigator
  
  土肥敏博
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Physiological role of cyclic ADP-ribose a novel endogenous agonist of ryanodine receptors
- Principal Investigator
  
  MORITA Katsuya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
The role of GABA neurons in general anesthesia: an in vivo microdialysis study
- Principal Investigator
  
  IRIFUNE Masahiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Refulation of PAF biosynthesis and its role in salivary secretionPrincipal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
The Function of Opioid Peptides Derived from Adrenal Medulla - Relationship to Stress and Immune System -
- Principal Investigator
  
  IMAI Yasuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
唾液腺における新しい細胞内情報伝達系としての血小板活性化因子(PAF)の役割Principal Investigator
- Principal Investigator
  
  土肥敏博
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
サイトカインの誘導するカルシウムチャンネル阻害タンパク質の検索
- Principal Investigator
  
  森田克也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
唾液線における血小板活性化因子(PAF)受容体発現とその機能Principal Investigator
- Principal Investigator
  
  土肥敏博
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Ca流入促進物質(CIF)の同定並びにその受容体Caチャンネルの構造と機能の解析
- Principal Investigator
  
  森田克也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
局所麻酔薬による神経伝達物質トランスポーター阻害の機序とその意義
- Principal Investigator
  
  北山滋雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
歯周病発症機序におけるリン脂質代謝産物の役割とその臨床評価法への応用
- Principal Investigator
  
  岡本莫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Hiroshima University
神経伝達物質トランスポーター遺伝子の多様性と神経疾患
- Principal Investigator
  
  KITAYAMA Shigeo
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Hiroshima University
A study on the mechanism and reconstruction of secretory process in salivary glands.Principal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
歯周病発症機構における血小板活性化因子(PAF)の役割
- Principal Investigator
  
  OKAMOTO Hiroshi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Hiroshima University
Regulation of signal transduction and GTP binding proteins for mucin release from submandibular glandsPrincipal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Studies on the neural functions of platelet-activating factorPrincipal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Effects of lipoxygenase on primary periodontitis
- Principal Investigator
  
  OKAMOTO Hiroshi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Hiroshima University
The Mucosecretion in the Submandibular Gland and the Role of Platelet-Activating Factor.Principal Investigator
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Pharmacological Studies on the Mechanism of Mucin Secretion from the Salivary Glands.
- Principal Investigator
  
  TSUJIMOTO Akira
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University

[Book] International Proceeding Division, 3rd International Congress on Neuropathic Pain NeuPSIG, Athens (Greece), 2010. International Association for the Study of Pain (1ASP) Working together for pain relief.2010
- Author(s)
  Morita K, Motoyama N, Kitayama T, Kanemastu T, Dohi T
- Total Pages
  252
- Publisher
  Editografica-Bologna (Italy)
- Data Source
  KAKENHI-PROJECT-22390349
[Book] 実験薬理学実践行動薬理学第3章「グリシントランスポーターを標的とした難治性疼痛治療薬の創薬戦略」2010
- Author(s)
  森田克也・本山直世・北山友也・兼松隆・土肥敏博
- Publisher
  株式会社金芳堂
- Data Source
  KAKENHI-PROJECT-22390349
[Book] 慢性疼痛治療における薬剤選定と治療薬開発第3部治療臨床を意識したこれからの疼痛治療薬開発動向-第1章有望な鎮痛カスケードの開発動向「グリシントランスポーター」2010
- Author(s)
  森田克也・土肥敏博
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-22390349
[Book] Mechanisms of phase-dependent pain-relief activity of glycine transp orter inhibitors after nerve injury; in MEDIMOND-Monduzzi Editore Internationa l Proceeding Division, 3rd Internationa l Congress on Neuropathic Pain NeuPSIG, Athens (Greece), 2010. International A ssociation for the Study of Pain (IASP) working together for pain relief (Chri stopher D Wells, Editors)2010
- Author(s)
  Morita K, Motoyama N, Kitayama T, Kanemastu T, Dohi T
- Publisher
  Editografica・Bologna (Italy)
- Data Source
  KAKENHI-PROJECT-21592421
[Book] Mechanisms of phase-dependent painrelief activity of glycine transporter inhibitors after nerve injury; in International Proceeding Division, 3rd International Congress on Neuropathic Pain NeuPSIG, Athens (Greece), 2010. International Association for the Study of Pain (IASP) working together for pain relief (Christopher D Wells, Editors)2010
- Author(s)
  Morita K, Motoyama N, Kitayama T, Kanematsu T, Dohi T
- Publisher
  Editografica・Bologna (Italy)
- Data Source
  KAKENHI-PROJECT-22390349
[Book] 実験薬理学実践行動薬理学第3章「グリシントランスポーターを標的とした難治性疼痛治療薬の創薬戦略」2010
- Author(s)
  森田克也・本山直世・北山友也・兼松隆・土肥敏博
- Publisher
  株式会社金芳堂
- Data Source
  KAKENHI-PROJECT-21592421
[Book] 慢性疼痛治療における薬剤選定と治療薬開発2010
- Author(s)
  森田克也, 土肥敏博
- Total Pages
  417
- Publisher
  技術情報協会(東京)
- Data Source
  KAKENHI-PROJECT-22390349
[Journal Article] 山間地域在住の高齢者との交流における看護学生の世代性及び対人援助力への影響2019
- Author(s)
  讃井真理，今坂鈴江，風間栄子，岡田京子，前信由美，新川雅子，空本恵美，加藤重子，石川孝則，田村和恵，岩本由美，平岡正史，平光　修，森田克也，土肥敏博，佐々木秀美
- Journal Title
  
  看護学統合研究
  
  Volume: 22 Pages: 10-24
- NAID
  120006595074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05603
[Journal Article] 看護師さんも知っておきたい話題の薬－高齢者の睡眠障害と睡眠薬－2019
- Author(s)
  土肥敏博，讃井真理，加藤重子，森田克也，今田真理子，加藤愛子，川本雪江　永石喜代子
- Journal Title
  
  看護学統合研究
  
  Volume: 20 Pages: 44-57
- Open Access
- Data Source
  KAKENHI-PROJECT-16H05603
[Journal Article] 平成28年度対人援助研究ブランディング看護・医療福祉部門超高齢社会における高齢者・認知症者の健康及び世代継承性・社会貢献活動に関する看護カフェモデルの構築第I編 - 高齢者カフェの実態調査報告 -2018
- Author(s)
  河野保子, 土肥敏博, 加藤重子, 讃井真理, 森田克也, 大塚文, 前信由美, 岩本由美, 田村和恵, 佐藤敦子, 今坂鈴江, 風間栄子, 岡田京子
- Journal Title
  
  看護学統合研究
  
  Volume: 19 Pages: 1-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05603
[Journal Article] 9：Down-regulation of zinc transporter-1 in astrocytes induces neuropathic pain via the brain-derived neurotrophic factor - K+-Cl- co-transporter-2 signaling pathway in the mouse spinal cord2016
- Author(s)
  Kitayama T, Morita K, Motoyama N, Dohi T.
- Journal Title
  
  Neurochem. Int.
  
  Volume: 101 Pages: 120-131
- DOI
  10.1016/j.neuint.2016.11.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462812, KAKENHI-PROJECT-15K15206, KAKENHI-PROJECT-16K11550
[Journal Article] Pain-releasing action of Platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action2013
- Author(s)
  Motoyama N, Morita K, Kitayama T, Shiraishi S, Uezono Y, Nishimura F, Kanematsu T, Dohi T
- Journal Title
  
  Eur J Pain
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390349
[Journal Article] Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action.2013
- Author(s)
  Motoyama N, Morita K, Kitayama T, Shiraishi S, Uezono Y, Nishimura F, Kanematsu T, Dohi T.
- Journal Title
  
  Eur J Pain
  
  Volume: (Epub ahead of print)(in press)
- DOI
  10.1002/j.1532-2149.2013.00289.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390349, KAKENHI-PROJECT-22590510, KAKENHI-PROJECT-24590740
[Journal Article] Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain.2009
- Author(s)
  Toshihiro Dohi, et al.
- Journal Title
  
  Pharmacology & Therapeutics (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390491
[Journal Article] Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca^<2+> rise and migration of human neutrophils.2008
- Author(s)
  Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi
- Journal Title
  
  Journal of Pharmacological Sciences 106-3
  
  Pages: 492-504
- NAID
  10024319493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592036
[Journal Article] MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility2007
- Author(s)
  Irifune, M., Katayama, S., Takarada, T., Shimizu, Y., Endo, C., Takata, T., Morita, K., Dohi, T., Sato, T., Kawahara, M
- Journal Title
  
  Can J Anaesth 54(12)
  
  Pages: 998-1005
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592037
[Journal Article] Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice2007
- Author(s)
  Irifune, M., Kikuchi, N., Saida, T., Takarada, T., Shimizu, Y., Endo, C., Morita, K., Dohi, T., Sato, T., Kawahara, M
- Journal Title
  
  Anesth Analg 104(6)
  
  Pages: 1415-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592037
[Journal Article] Mechanisms of pain sensitization and the treatments2006
- Author(s)
  T.Dohi, K.Morita, N.Morioka, J.Abdin, T.Kitayama, N.Motoyama, F.Zohn
- Journal Title
  
  Hiroshima Conference on Education and Science in Dentistry, 2006
  
  Pages: 87-95
- NAID
  120006665073
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Mechanisms of pain sensitization and the treatments2006
- Author(s)
  T.Dohi, K.Morita, N.Morioka, J.Abdln, T.Kitayama, N.Motoyama, R.Zohn
- Journal Title
  
  Hiroshima Conference on Education and Science in Dentistry, 2006
  
  Pages: 87-95
- NAID
  120006665073
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Cyclic ADP-ribose requires FK506-binding protein to regulate intracellular Ca^<2+> dynamics and catecholamine release in acetylcholine-stimulated bovine adrenal chromaffin cells.2006
- Author(s)
  Katsuya Morita, Tomoya Kitayama, Shigeo Kitayama, Toshihiro Dohi
- Journal Title
  
  Journal of Pharmacological Sciences 101-1
  
  Pages: 40-51
- NAID
  130000073091
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592036
[Journal Article] Mechanisms of pain sensitization and the treatments2006
- Author(s)
  T.Dohi
- Journal Title
  
  Hiroshima Conference on Education and Science in Dentistry
  
  Pages: 87-95
- NAID
  120006665073
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] 脊髄の痛覚伝導における血小板活性化因子(PAF)の役割2006
- Author(s)
  土肥敏博, 森田克也, 森岡徳光, Md.Joynal Abdin, 北山友也, 北山滋雄, 仲田義啓
- Journal Title
  
  日本薬理学雑誌 127
  
  Pages: 18-24
- NAID
  10017495004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] 脊髄の痛覚伝導における血小板活性化因子(PAF)の役割2006
- Author(s)
  土肥敏博, 森田克也, 森岡徳光, Md.JoynalAbdin, 北山友也, 北山滋雄, 仲田義啓
- Journal Title
  
  日本薬理学雑誌 127
  
  Pages: 18-24
- NAID
  10017495004
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Role of platelet-activating factor (PAF) in pain signal transduction in spinal cord of mice.2005
- Author(s)
  T.Dohi
- Journal Title
  
  Folia Pharmacological Japonica 127
  
  Pages: 18-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Nonsteroidal anti-inflammatory drugs potentiate 1-methyl-4-phenyl-pyridinium (MPP^<+>)-induced cell death by promoting the intracellular accumulation of MPP^+ in PC12 cells.2004
- Author(s)
  N.Morioka, K.Kumagai, K.Morita, S.Kitayama, T.Dohi
- Journal Title
  
  The Journal of Pharmacology and Experimental Therapeutics 310
  
  Pages: 800-807
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice.2004
- Author(s)
  K.Morita, N.Morioka, J.Abdin, S.Kitayama, Y.Nakata, T.Dohi
- Journal Title
  
  Pain 111
  
  Pages: 351-359
- NAID
  120000881206
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Interleukin-1 inhibits voltage-dependent P/Q-type Ca^<2+> channel associated with the inhibition of the rise of intracellular Ca^<2+> concentration and catecholamine release in adrenal chromaffin cells.2004
- Author(s)
  K.Morita, T.Miyasako, S.Kitayama, T.Dohi
- Journal Title
  
  Biochimica Biophysica Acta 1673
  
  Pages: 160-169
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice2004
- Author(s)
  K.Morita, N.Morioka, J.Abdin, S.Kitayama, Y.Nakata, T.Dohi
- Journal Title
  
  Pain 111
  
  Pages: 351-359
- NAID
  120000881206
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Interleukin-1 inhibits voltage-dependent P/Q-type Ca^<2+> channel associated with the inhibition of the rise of intracellular Ca^<2+> concentration and catecholamine release in adrenal chromaffin cells.2004
- Author(s)
  K.Morita, T.Miyasako, S.Kitayama, T.Dohi
- Journal Title
  
  Biochimica Biophysiea Acta 1673
  
  Pages: 160-169
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Nonsteroidal ant-inflammatory drugs potentiate 1-methyl-4-phenyl-pyridinium (MPP^+)-induced cell death by promoting the intracellularaccumulation of MPP^+ in PC12 cells.2004
- Author(s)
  N.Morioka, K.Kumagai, K.Morita, S.Kitayama, T.Dohi
- Journal Title
  
  The Journal of Pharmacology and Experimental Therapeutics 310
  
  Pages: 800-807
- Data Source
  KAKENHI-PROJECT-15390562
[Patent] 癌性疼痛を処理するための組成物およびその利用2011
- Inventor(s)
  森田克也,土肥敏博,本山直世,北山友也,兼松隆,白石成二
- Industrial Property Rights Holder
  国立大学法人広島大学,独立行政法人国立がん研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2011-12-09
- Overseas
- Data Source
  KAKENHI-PROJECT-22390349
[Patent] 疼痛を処理するための組成物およびその利用2011
- Inventor(s)
  森田克也,土肥敏博,本山直世,北山友也,兼松隆,白石成二
- Industrial Property Rights Holder
  国立大学法人広島大学,独立行政法人国立がん研究センター
- Filing Date
  2011-12-09
- Overseas
- Data Source
  KAKENHI-PROJECT-21592421
[Patent] 疼痛を処理するための組成物およびその利用2011
- Inventor(s)
  森田克也, 土肥敏博, 本山直世, 北山友也, 兼松隆, 白石成二
- Industrial Property Rights Holder
  国立大学法人広島大学独立行政法人国立がん研究センター
- Filing Date
  2011-12-09
- Overseas
- Data Source
  KAKENHI-PROJECT-21592421
[Patent] 癌性痛痛を処理するための組成物およびその利用2011
- Inventor(s)
  森田克也, 土肥敏博, 本山直世, 北山友也, 兼松隆, 白石成二
- Industrial Property Rights Holder
  国立大学法人広島大学 ; 独立行政法人国立がん研究センター
- Filing Date
  2011-12-09
- Overseas
- Data Source
  KAKENHI-PROJECT-22390349
[Patent] 疼痛を処理するための組成物およびその利用2010
- Inventor(s)
  森田克也,土肥敏博,本山直世,北山友也,兼松隆,白石成二
- Industrial Property Rights Holder
  国立大学法人広島大学,独立行政法人国立がん研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2010-274581
- Filing Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22390349
[Patent] 疼痛を処理するための組成物およびその利用2010
- Inventor(s)
  森田克也,土肥敏博,本山直世,北山友也,兼松隆,白石成二
- Industrial Property Rights Holder
  国立大学法人広島大学,独立行政法人国立がん研究センター
- Industrial Property Number
  2010-274581
- Filing Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21592421
[Patent] 痛痛を処理するための組成物およびその利用2010
- Inventor(s)
  森田克也, 土肥敏博, 本山直世, 北山友也, 兼松隆, 白石成二
- Industrial Property Rights Holder
  国立大学法人広島大学 ; 独立行政法人国立がん研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22390349
[Patent] 疼痛を処理するための組成物およびその利用2010
- Inventor(s)
  森田克也, 土肥敏博, 本山直世, 北山友也, 兼松隆, 白石成二
- Industrial Property Rights Holder
  国立大学法人広島大学独立行政法人国立がん研究センター
- Industrial Property Number
  2010-274581
- Filing Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] Health Status of Elderly People Who Participated in the Self-Health Monitoring Cafe Conducted in the Super Aging Areas in Japan (2)2019
- Author(s)
  M. Sanai, M. Shinkawa, T. Ishikawa, M. Hiraoka, K. Morita and T. Dohi
- Organizer
  International Council of Nurses Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05603
[Presentation] Role of spinal LPCAT2, an inducible PAF synthesis enzyme on development and maintenance of painful peripheral neuropathy models in mice.2018
- Author(s)
  Morita K, Motoyama N, Kitayama T, Sanai M, Hashimoto M, Tsuchii A, Kato K, Kawai Y and Dohi T.
- Organizer
  18th World congress of basic and clinical pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11550
[Presentation] Seretedd extracellular miRNA, let-7b-5p causes neuropathic pain via TLR7 inperipheral nerve injury.2018
- Author(s)
  Motoyama N, Morita K, Asano S, Jodo Y, Shigaki M, Sanai M and Dohi T
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology；WCP2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05603
[Presentation] Secreted extracellular miRNA, Let-7b-5p causes neuropathic pain via TLR7 in peripheral nerve injury.2018
- Author(s)
  Motoyama N, Morita K, Asano S, Jodo Y, Shigaki M, Sanai M and Dohi T.
- Organizer
  18th World congress of basic and clinical pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11550
[Presentation] Role of spinal LPCAT2, an inducible PAF synthesis enzyme on development and maintenance of painful peripheral neuropathy models in mice.2018
- Author(s)
  Morita K, Motoyama N, Kitayama T, Sanai M, Hashimoto M, Tauchii A Kato K, Kawai Y and Dohi T
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology；WCP2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05603
[Presentation] 血小板活性化因子(PAF)合成酵素LPCAT2阻害薬の難治性疼痛の発症と維持における役割2018
- Author(s)
  本山直世，森田克也，永安慎太郎，平田-土屋志津，進藤　智，西藤法子，柴　秀樹，土肥敏博
- Organizer
  第149回日本歯科保存学会2018年度秋季学術大会
- Data Source
  KAKENHI-PROJECT-16K11550
[Presentation] 介護予防：運動器機能の評価と唾液中神経栄養因子を指標とした効果的な介入の検討2018
- Author(s)
  讃井真理，新川雅子，石川孝則，山田晃子，上林聡子，岩本由美，平岡正史，田村和恵，前信由美，平光修，森田克也，土肥敏博
- Organizer
  第8回日本認知症予防学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05603
[Presentation] Extracellular miRNA causes neuropathic pain via spinal TLR7 in peripheral nerve injury.「神経障害性疼痛の発症における脊髄miRNA/TLR7系の役割」2017
- Author(s)
  森田克也，本山直世，土肥敏博
- Organizer
  第90回日本薬理学年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K15206
[Presentation] Role of spinal LPCAT2, an inducible PAF synthesis enzyme on development and maintenance of painful peripheral neuropathy models in mice 「神経障害性疼痛の発症と維持機構における誘導型血小板活性化因子(PAF)合成酵素LPCAT2の役割」2016
- Author(s)
  Morita K, Motoyama N, Kitayama T, Kanematsu T and Dohi T
- Organizer
  第89回日本薬理学年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K15206
[Presentation] 11：Anti-allodynic effect of spinal LPCAT2, an inducible PAF synthesis enzyme in neuropathic pain models in mice2016
- Author(s)
  Motoyama N., Morita K., Kitayama T., Shiba H., Dohi T.
- Organizer
  第49回広島大学歯学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-16K11550
[Presentation] 10：血小板活性化因子(PAF)合成酵素LPCAT2の難治性疼痛における鎮痛作用2016
- Author(s)
  本山直世，森田克也，柴　秀樹，土肥敏博
- Organizer
  第36回日本歯科薬物療法学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-16K11550
[Presentation] 血小板活性化因子(PAF)合成酵素LPCAT2の難治性疼痛における役割2016
- Author(s)
  本山直世，森田克也，土肥敏博
- Organizer
  第36回日本歯科薬物療法学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-15K15206
[Presentation] 難治性疼痛の発症と維持における血小板活性化因子(PAF)合成酵素LPCAT2の役割「Role of the novel Platelet-Activating factor (PAF) synthetase LPCAT2 on chronic pain in mouse models」2015
- Author(s)
  本山直世，森田克也，北山友也，柴　秀樹，土肥敏博
- Organizer
  第142回日本歯科保存学会 2015年度春季学術大会
- Place of Presentation
  北九州
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-15K15206
[Presentation] 難治性疼痛の発症における新規エストロゲン受容体GPR30の役割2012
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  第54回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  郡山市
- Year and Date
  2012-09-15
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 細胞膜エストロゲン受容体GPR30を介した疼痛制御機構に関する研究2012
- Author(s)
  本山直世・森田克也・西村英紀・兼松隆・土肥敏博
- Organizer
  第32回日本歯科薬物療法学会
- Place of Presentation
  大阪市
- Year and Date
  2012-06-30
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 顎顔面領域の慢性疼痛の発症と維持におけるグリシン神経の役割と新規治療薬の開発2012
- Author(s)
  本山直世・森田克也・西村英紀・兼松隆・土肥敏博
- Organizer
  第22回日本歯科医学会総会
- Place of Presentation
  大阪市
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 難治性疼痛の発症における血小板活性化因子(PAF)の関与2011
- Author(s)
  本山直世・森田克也・西村英紀・兼松隆・土肥敏博本山直世・森田克也・西村英紀・兼松隆・土肥敏博
- Organizer
  第31回日本歯科薬物療法学会
- Place of Presentation
  千葉市
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] グリシントランスポーター(GlyTs)の抗侵害作用発現機序に関する研究2011
- Author(s)
  本山直世, 森田克也, 北山友也, 西村英紀, 兼松隆, 土肥敏博
- Organizer
  日本歯科保存学会2011年度春季学術大会(第134回)
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 慢性難治性疼痛の発症と維持機構における血小板活性化因子(PAF)の役割2011
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  第53回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  岐阜市
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] グリシントランスポーター(GlyTs)の抗侵害作用発現機序に関する研究2011
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  日本歯科保存学会2011年度春季学術大会(第134回)
- Place of Presentation
  浦安市
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 難治性疼痛の発症における血小板活性化因子(PAF)の関与2011
- Author(s)
  本山直世・森田克也・西村英紀・兼松隆・土肥敏博
- Organizer
  第31回日本歯科薬物療法学会
- Place of Presentation
  千葉市
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] グリシントランスポーター(GlyTs)の抗侵害作用発現機序に関する研究2011
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  日本歯科保存学会2011年度春季学術大会(第134回)
- Place of Presentation
  浦安市
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 難治性疼痛の発症における血小板活性化因子(PAF)の関与2011
- Author(s)
  本山直世, 森田克也, 西村英紀, 兼松隆, 土肥敏博
- Organizer
  第31回日本歯科薬物療法学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 慢性難治性疼痛の発症と維持機構における血小板活性化因子(PAF)の役割2011
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  第53回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  岐阜市
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 慢性難治性疼痛の発症と維持機構における血小板活性化因子(PAF)の役割2011
- Author(s)
  本山直世, 森田克也, 北山友也, 西村英紀, 兼松隆, 土肥敏博
- Organizer
  第53回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] グリシントランスポーターと神経障害性疼痛2010
- Author(s)
  本山直世, 森田克也, 北山友也, 兼松隆, 土肥敏博
- Organizer
  第5回トランスポーター研究会年会(JTRA2010)「トランスポーター研究の魅力を探る」「シンポジウム : 神経伝達物質トランスポーターと神経疾患」
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 疼痛治療ターゲットとしてのグリシントランスポーター「シンポジウム:疼痛治療の新しいターゲット」2010
- Author(s)
  森田克也・本山直世・北山友也・兼松隆・土肥敏博
- Organizer
  社団法人日本麻酔科学会第57回学術集会,第13回アジア・オーストラレーシア麻酔科学会
- Place of Presentation
  福岡市
- Year and Date
  2010-06-03
- Invited
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 疼痛治療ターゲットとしてのグリシントランスポーター「シンポジウム:疼痛治療の新しいターゲット」2010
- Author(s)
  森田克也, 本山直世, 北山友也, 兼松隆, 土肥敏博
- Organizer
  社団法人日本麻酔科学会第57回学術集会,第13回アジア・オーストラレーシア麻酔科学会
- Place of Presentation
  福岡市(招待講演)
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] グリシントランスポーターと神経障害性疼痛「トランスポーター研究の魅力を探る」「シンポジウム:神経伝達物質トランスポーターと神経疾患」2010
- Author(s)
  本山直世, 森田克也, 北山友也, 兼松隆, 土肥敏博
- Organizer
  第5回トランスポーター研究会年会(JTRA2010)
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 神経因性疼痛発症時に認められるグリシンシグナルの変調機構2010
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  第49回広島県歯科医学会・第94回広島大学歯学会
- Place of Presentation
  広島市
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 疼痛治療ターゲットとしてのグリシントランスポーター2010
- Author(s)
  森田克也, 本山直世, 北山友也, 兼松隆, 土肥敏博
- Organizer
  社団法人日本麻酔科学会第57回学術集会, 第13回アジア・オーストラレーシア麻酔科学会「シンポジウム : 疼痛治療の新しいターゲット」
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] Glycine transpoter inhibitors as a novel drug discovery strategy for neuropathic pain2010
- Author(s)
  Dohi T, Morita K, Motoyama N, Kitayama T, Kanemastu T
- Organizer
  Third International Congress on Neuropathic Pain (NeuPSIG)
- Place of Presentation
  Athens (Greece)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] Anti-allodynia effects of glycine transporter inhibitors in neuropathic pain models2010
- Author(s)
  Motoyama N, Morita K, Kitayama T, Nishimura F, Kanematsu T, Dohi T
- Organizer
  58th Annual Meeting of Japanese Association for Dental Research
- Place of Presentation
  Kitakyushu
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] Antiallodynia effects of glycine transporter inhibittors in neuropathic pain models2010
- Author(s)
  Motoyama N, Morita K, Kitayama T, Nishimura F, Kanematsu T, Dohi T
- Organizer
  58th Annual Meeting of Japanese Association for Dental Research
- Place of Presentation
  Kitakyushu
- Year and Date
  2010-11-21
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 神経障害性疼痛発症における抑制性グリシンシグナルの変調機講に関する研究2010
- Author(s)
  本山直世・北山友也・西村英紀・兼松隆・森田克也・土肥敏博
- Organizer
  第52回日本歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  東京
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 神経因性疼痛初期疼痛におけるクロライドイオン輸送体発現制御機構に関する研究2010
- Author(s)
  北山友也・本山直世・森田克也・西村英紀・兼松隆・土肥敏博
- Organizer
  第19回神経行動薬理若手研究者の集い
- Place of Presentation
  岡山市
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 神経障害性疼痛発症における抑制性グリシンシグナルの変調機講に関する研究2010
- Author(s)
  本山直世・北山友也・西村英紀・兼松隆・森田克也・土肥敏博
- Organizer
  第52回日本歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  東京
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] Mechanisms of phase-dependent pain-relief activity of glycine transporter inhibitors after nerve injury2010
- Author(s)
  Morita K, Motoyama N, Kitayama T, Jinnin Y, Nishimura F, Kanematsu T, Dohi T
- Organizer
  Third International Congress on Neuropathic Pain (NeuPSIG)
- Place of Presentation
  Athens (Greece)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] Mechanisms of phase-dependent pain-relief activity of glycine transporter inhibitors after nerve injury.2010
- Author(s)
  Morita K, Motoyama N, Kitayama T, Jinnin Y, Nishimura F, Kanemastu T, Dohi T
- Organizer
  Third International Congress on Neuropathic Pain (NeuPSIG)
- Place of Presentation
  Athens (Greece)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] グリシントランスポーターと神経障害性疼痛「トランスポーター研究の魅力を探る」2010
- Author(s)
  本山直世・森田克也・北山友也・兼松隆・土肥敏博
- Organizer
  シンポジウム:神経伝達物質トランスポーターと神経疾患,第5回トランスポーター研究会年会(JTRA 2010)
- Place of Presentation
  東京 (招待講演)
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain.2010
- Author(s)
  Dohi T, Morita K, Motoyama N, Kitayama T, Kanemastu T
- Organizer
  Third International Congress on Neuropathic Pain (NeuPSIG)
- Place of Presentation
  Athens (Greece)
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 慢性難治性疼痛の発症と維持におけるグリシン神経の役割2010
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  第19回神経行動薬理若手研究者の集いシンポジウム発表
- Place of Presentation
  岡山市
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] グリシントランスポーターと神経障害性疼痛「トランスポーター研究の魅力を探る」「シンポジウム:神経伝達物質トランスポーターと神経疾患」2010
- Author(s)
  本山直世・森田克也・北山友也・兼松隆・土肥敏博
- Organizer
  第5回トランスポーター研究会年会 (JTRA 2010)
- Place of Presentation
  東京
- Year and Date
  2010-07-10
- Invited
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] Mechanisms of phase-dependent pain-relief activity of glycine transporter inhibitors after nerve injury2010
- Author(s)
  Morita K, Motoyama N, Kitayama T, Jinnin Y, Nishimura F, Kanemastu T, Dohi T
- Organizer
  Third International Congress on Neuropathic Pain (NeuPSIG)
- Place of Presentation
  Athens (Greece)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] Mechanisms of phase-dependent pain-relief activity of glycine transporter inhibitors after nerve injury.2010
- Author(s)
  Morita K, Motoyama N, Kitayama T, Jinnin Y, Nishimura F, Kanemastu T, Dohi T
- Organizer
  Third International Congress on Neuropathic Pain (NeuPSIG)
- Place of Presentation
  Athens (Greece)
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 神経因性疼痛発症時に認められるグリシンシグナルの変調機構2010
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  第49回広島県歯科医学会・第94回広島大学歯学会
- Place of Presentation
  広島市
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 神経障害性疼痛発症とグリシンシグナルの変調2010
- Author(s)
  森田克也・本山直世・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪市
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain2010
- Author(s)
  Dohi T, Morita K, Motoyama N, Kitayama T, Kanematsu T
- Organizer
  Third International Congress on Neuropathic Pain (NeuPSIG)
- Place of Presentation
  Athens (Greece)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22390349
[Presentation] 三環系抗うつ薬の抗アロディニア作用におけるグリシン神経の関与2010
- Author(s)
  神人友樹・森田克也・本山直世・北山友也・北山滋雄・西村英紀・兼松隆・土肥敏博
- Organizer
  第19回神経行動薬理若手研究者の集い
- Place of Presentation
  岡山市
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] Anti-allodynia Effects of Glycine Transporter inhibitors in Neuropathic Pain Models2010
- Author(s)
  Motoyama N , Morita K, Kitayama T, Nishimura F, Kanemastu T, Dohi T
- Organizer
  58th Annual Meeting of Japanese Association for Dental Research
- Place of Presentation
  Kitakyushu
- Year and Date
  2010-11-21
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 慢性難治性疼痛の発症と維持におけるグリシン神経の役割2010
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・兼松隆・土肥敏博
- Organizer
  第19回神経行動薬理若手研究者の集い
- Place of Presentation
  岡山市 (シンポジウム発表)
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 疼痛治療ターゲットとしてのグリシントランスポーター2010
- Author(s)
  森田克也・本山直世・北山友也・兼松隆・土肥敏博
- Organizer
  シンポジウム:疼痛治療の新しいターゲット,社団法人日本麻酔科学会第57回学術集会,第13回アジア・オーストラレーシア麻酔科学会
- Place of Presentation
  福岡市 (招待講演)
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 血小板活性化因子(PAF)の脊髄腔内投与によるアロディニア発症へのグリシン受容体α3の関与2009
- Author(s)
  本山直世・森田克也・北山友也・西村英紀・土肥敏博
- Organizer
  第130回日本歯科保存学会2009年度春季学術大会
- Place of Presentation
  札幌市
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 慢性・難治性疼痛管理における血小板活性化因子(PAF)受容体阻害薬の有用性について2009
- Author(s)
  貴船幸基・本山直世・北山友也・西村英紀・兼松隆・森田克也・土肥敏博
- Organizer
  第51回歯科基礎医学会学術大会・総会
- Place of Presentation
  新潟市
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] ストレプトゾトシン誘発有痛性糖尿病モデルに対するグリシントランスポーター(GlyT)阻害薬の寛解作用2009
- Author(s)
  北山友也・本山直世・西村英紀・兼松隆・森田克也・土肥敏博
- Organizer
  第115回日本薬理学会近畿部会
- Place of Presentation
  金沢市
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] ニコチンによるヒトドパミントランスポーター遺伝子転写活性の促進作用2009
- Author(s)
  十川紀夫, 大山和美, 十川千春, 平井幹士, 森田克也, 土肥敏博, 北山滋雄
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-19592146
[Presentation] 痛み発症における血小板活性化因子(PAF)受容体の関与2009
- Author(s)
  本山直世・貴船幸基・森田克也・北山友也・神人友樹・西村英紀・兼松隆・土肥敏博
- Organizer
  第131回日本歯科保存学会 2009年度秋季学術大会
- Place of Presentation
  仙台市
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 痛み発症における血小板活性化因子(PAF)受容体の関与2009
- Author(s)
  本山直世・貴船幸基・森田克也・北山友也・神人友樹・西村英紀・兼松隆・土肥敏博
- Organizer
  第131回日本歯科保存学会2009年度秋季学術大会
- Place of Presentation
  仙台市
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] 糖尿病性疼痛モデルにおけるグリシントランスポーター阻害薬の抗アロディニア作用2009
- Author(s)
  本山直世・北山友也・神人友樹・西村英紀・兼松隆・森田克也・土肥敏博
- Organizer
  第51回歯科基礎医学会学術大会・総会
- Place of Presentation
  新潟市
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-21592421
[Presentation] ニコチンによるヒトドパミントランスポーター遺伝子転写活性の調節2008
- Author(s)
  大山和美, 十川千春, 十川紀夫, 平井幹士, 小谷洋平, 松岡礼子, 森田克也, 土肥敏博, 北山滋雄
- Organizer
  第113回日本薬理学会近畿部会
- Place of Presentation
  岡山市
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-19592146
[Presentation] ヒトドパミントランスポーター遺伝子転写活性に対するニコチンの調節作用について2008
- Author(s)
  十川紀夫, 大山和美, 十川千春, 平井幹士, 森田克也, 土肥敏博, 北山滋雄
- Organizer
  第50回歯科基礎医学会学術大会
- Place of Presentation
  東京都
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-19592146
[Presentation] Intrathecal injection of cyclic ADP-ribose induces hyperalgesia and allodynia2006
- Author(s)
  Naoyo Motoyama, Katsuya Morita, Koki Kifune, Norimitsu Morioka, Tomoya Kitayama, Toshihiro Dohi
- Organizer
  The 48th Annual Meeting of Japanese Association for Oral Biology
- Place of Presentation
  Tsurumi
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592036

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Dohi Toshihiro 土肥 敏博

土肥 敏博 ドヒ トシヒロ

DOHI Toshihiro 土肥 敏博

土肥 博敏 ドヒ ヒロトシ

土肥 俊博 ドヒ トシヒロ

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難治性疼痛治療薬，血小板活性化因子合成酵素阻害薬の疼痛治療戦略と歯科領域への応用Ongoing

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高齢者における皮膚潰瘍・褥瘡に対する効果的治療法・予防法の開発Ongoing

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アロディニア発症の分子機構とその治療薬の開発に関する研究Principal Investigator

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Dohi Toshihiro 土肥敏博

土肥敏博ドヒトシヒロ

DOHI Toshihiro 土肥敏博

土肥博敏ドヒヒロトシ

土肥俊博ドヒトシヒロ