NISHIYAMA Mariko 西山眞理子

Researcher Number	00092081
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2014: 千葉大学, 医学(系)研究科(研究院), 助教 2013: 千葉大学, 大学院医学研究院, 助教 2008 – 2010: 千葉大学, 大学院・医学研究院, 助教 2006: Chiba University, Graduate School of Medicine, Research Associate, 大学院医学研究院, 助手 2005 – 2006: 千葉大学, 大学院・医学研究院, 助手 … More 2002 – 2003: 千葉大学, 大学院・医学研究院, 助手 1998 – 2000: Chiba University Graduate School of Medicine, Department of Biochemistry and Mol, 大学院・医学研究科, 助手 1997 – 1998: 千葉大学, 医学部, 助手 1995: 千葉大学, 医科部, 助手 1994 – 1995: 千葉大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / 血管生物学 Except Principal Investigator General pharmacology / General pharmacology / Functional biochemistry / 体育学 / Nerve anatomy/Neuropathology
Keywords	Principal Investigator アンジオテンシンII / ウロテンシンII / RGSタンパク質 / 薬理学 / エンドセリン受容体 / エンドセリン / 収縮 / 平滑筋 / 血管 Except Principal Investigator GPCR … More / 脱感作 / エンドセリン受容体 / エンドセリン / RGS / オーファン受容体 / ゲノム構造 / 生理活性ペプチド / JNK / PPAR-α / G蛋白質共役受容体キナーゼ / Endothelin / アンジオテンシン受容体 / アンジオテンシン / バイオインフォーマティクス / Gタンパク質共役受容体 / bioinformatics / genome structure / bioactive peptide / orphan GPCR / MAP kinases / aortic banding model / rat cardiomyocytes / Endothelin(ET)-1 / Fenofibrate / cardiac hypertrophy / MAPキナーゼ / 冠動脈結紮モデルラット / ラット心筋細胞 / エンドセリン(ET)-1 / fenofibrate / 心肥大 / endothelin / angiotensin / G protein / G蛋白質αサブユニット / G蛋白質 / REVERSE TORERANCE / DESENSITIZATION (TORERANCE) / INTRACELLULAR CA2+TRANSIENT / ANGIOTENSIN RECEPTOR / ENDOTHELIN RECEPTOR / G-PROTEIN COUPLED RECEPTOR / REGULATOR OF G-PROTEIN SIGNALING (RGS) / 耐性 / 細胞内Ca+移動 / 細胞内Ca^+移動 / G蛋白質シグナル調節蛋白質(RGS) / 逆耐性 / 脱感作(耐性) / 細胞内Ca2+移動 / G蛋白質情報伝達系 / G蛋白質シグナル調箇蛋白質(RGS) / superior cervical ganglion / electron microscopy / synaptic spinule / perforated synapse / synapse remodeling / long-term potentiation / synaptic plasticity / パーフォレイテッド・シナプス / 刺激後増強 / 上頚神経節 / 上頸神経節 / 電子顕微鏡 / シナプス小棘 / 解離性シナプス / シナプス再構築 / 長期増強 / シナプス可塑性 / Regulators of G protein signaling / Binding experiment / Desensitization / Endothelin receptor antagonists / Endothelin receptors / 結合実験 / G蛋白質シグナル調節因子(RGS) / エンドセリン拮抗薬 / Hirschsprung disease / Endothelin receptor / 平滑筋 / 血管 / Hirshsprung病 / エンドセリンレセプター / 国際情報交流 / 「国際情報交換」 / スピノフィリン / 閉経後高血圧 / バイオインフオーマティクス / G蛋白質共役受容 / G蛋白質共役受容体 / in silico / G蛋白質共役型受容体 / 生合成経路 / ボンベシン受容体 / リガンド予測 / リガンド Less

A study on inhibitory regulation of urotensin II receptor signaling by RGS proteins: an attempt to find potential novel anti-arteriosclerotic agentsPrincipal Investigator
- Principal Investigator
  
  NISHIYAMA Mariko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Chiba University
Analysis of a novel mechanism responsible for postmenopausal hypertension
- Principal Investigator
  
  KIMURA Sadao
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Chiba University
In silico searching for biologically active peptides with a C-terminal amide based on h uman genome DNA structure
- Principal Investigator
  
  KIMURA Sadao
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Chiba University
An exhaustive search of new bioactive peptides based on prediction by bioinformatics using human genome structures
- Principal Investigator
  
  KIMURA Sadao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Chiba University
オーファン受容体リガンドの新しい高感度アッセイ法による探索
- Principal Investigator
  
  木村定雄
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Chiba University
The role of energy metabolic abnormality in cardiac hypertrophy.
- Principal Investigator
  
  KASUYA Yoshitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  Chiba University
ANALYSIS OF REGURATORY MECHANISM OF RGS ON DESENSITIZATION AND TORERANCE.
- Principal Investigator
  
  MORIO Kayoko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  CHIBA UNIVERSITY
Regulation of G protein-signaling by RGS proteins in cardiovascular system
- Principal Investigator
  
  KIMURA Sadao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  CHIBA UNIVERSITY
Functional morphology on the synaptic plasticity : Rapid remodeling of the synapse during long-term potentiation.
- Principal Investigator
  
  KADOTA Tomoko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Chiba University
Analysis of the mechanism by nobel regulators of endothelin receptor signaling
- Principal Investigator
  
  KIMURA Sadao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Chiba University Graduate School of Medicine
血管収縮に関与する新しいエンドセリンB受容体サブタイプの特性と生理的意義Principal Investigator
- Principal Investigator
  
  西山真理子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Chiba University
Cloning of new endothelin B receptor and its physiological significance
- Principal Investigator
  
  KIMURA Sadao
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Chiba University

All 2014 2013 2012 2011 2010 2006 2005

All Journal Article Presentation Book

[Book] In silico search for biologically active peptides. in "Handbook of the Biologically Active Peptides", 2nd edition(edited by Kastin AJ)2013
- Author(s)
  Nishiyama M, Ishii M, Hirose S, Yamasaki H, Kimura S
- Publisher
  Academic Press(Chapter 239)
- Data Source
  KAKENHI-PROJECT-23590296
[Book] Handbook of the Biologically Active Peptides2013
- Author(s)
  Nishiyama M, Ishii M, Hirose S, Yamasaki H, Kimura S
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-23590296
[Journal Article] Potent and selective inhibition of angiotensin AT1 receptor signalling by RGS2: roles of its N-terminal domain2011
- Author(s)
  Matsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S
- Journal Title
  
  Cellular Signalling
  
  Volume: Vol.23、No.6 Issue: 6 Pages: 1041-1049
- DOI
  10.1016/j.cellsig.2011.01.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590296
[Journal Article] Potent and selective inhibition of angiotensin AT1 receptor signalling by RGS2 : Roles of its N-terminal domain.2011
- Author(s)
  Matsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S
- Journal Title
  
  Cellular Signalling 23(6)
  
  Pages: 1041-1049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590248
[Journal Article] Potent and selective inhibition of angiotensin AT1 receptor signaling by RGS2 : Roles of its N-terminal dolnain.2011
- Author(s)
  atsuzaki N, Nishiyama M, Song D, Moroi K, Kimura S
- Journal Title
  
  Cellular Signalling
  
  Volume: 23 Pages: 1041-1049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590248
[Journal Article] Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells.2006
- Author(s)
  Matsuo Y, Amano S, Furuya M, Namiki K, Sakurai K, Nishiyama M, Sudo T, Tatsumi K, Kuriyama T, Kimura S, Kasuya Y.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 36767-36775
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590214
[Journal Article] Involvement of p38alpha mitgen-activayed protein kinase in lung metastasis of tumor cells.2006
- Author(s)
  Matsuo Y, Amano S, Furuya M, Namiki K, Sakurai K, Nishiyama M, Sudo T, Tatsumi K, Kuriyama T, Kimura S, Kasuya Y
- Journal Title
  
  J. Biol. Chem. 281・48
  
  Pages: 36767-36775
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590214
[Journal Article] Pathophysiology of Tumor Neovascularization.2005
- Author(s)
  Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ishikura H
- Journal Title
  
  Vasc.Health Risk Management 1・4
  
  Pages: 277-290
- Data Source
  KAKENHI-PROJECT-17590214
[Journal Article] Pathophysiology of Tumor Neovascularization.2005
- Author(s)
  Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ishikura H
- Journal Title
  
  Vasc. Health Risk Management I(4)
  
  Pages: 277-290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590214
[Journal Article] Pathophysiology of Tumor Neovascularization.2005
- Author(s)
  Furuya M, Nishiyama M, Kasuya Y, Kimura S, Ishikura H
- Journal Title
  
  Vasc. Health Risk Management 1・4
  
  Pages: 277-290
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590214
[Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS8の強力な抑制効果：　RGSドメインのC末端部分の重要性2014
- Author(s)
  西山眞理子、住宮菜弥香、木村定雄
- Organizer
  日本薬理学会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23590296
[Presentation] Potent inhibitory effects of RGS8 on intracellular calcium responses to vasoactive peptides: importance of the C-terminal part of its RGS domain2014
- Author(s)
  Mariko Nishiyama, Sayaka Sumimiya, Sadao Kimura
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-25670125
[Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS8の強力な抑制効果:RGSドメインのC末端部分の需要性2014
- Author(s)
  西山眞理子, 住宮菜弥香, 木村定雄
- Organizer
  第87回日本薬理学会総会
- Place of Presentation
  仙台
- Year and Date
  2014-03-20
- Data Source
  KAKENHI-PROJECT-23590296
[Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS2、RGS3及びRGS8の強力な抑制効果2012
- Author(s)
  宋丹、西山眞理子、木村定雄
- Organizer
  日本薬理学会年会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-23590296
[Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS2, RGS3, RGS8の強力な抑制効果2012
- Author(s)
  宋丹, 西山眞理子, 木村定雄
- Organizer
  第85回日本薬理学会総会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-23590296
[Presentation] RGS2の選択的なアンジオテンシンAT1受容体シグナリング抑制効果におけるN末端部サブドメインの役割2011
- Author(s)
  松崎直子・西山眞理子・宋丹・諸井佳代子・木村定雄
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-20590248
[Presentation] RGS2の選択的なアンジオテンシンATI受容体シグナリング抑制効果におけるN末端サブドメインの役割2011
- Author(s)
  松崎直子, 西山真理子, 諸井佳代子, 木村定雄
- Organizer
  日本薬理学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-20590248
[Presentation] RGS2の選択的なAT1a受容体シグナリング抑制効果-RGS2のN末端部の役割-2010
- Author(s)
  松崎直子、西山真理子、諸井佳代子、木村定雄
- Organizer
  日本薬理学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-20590248
[Presentation] RGS2の選択的なAT1受容体シグナリング抑制効果-RGS2のN末端ドメインの役割-2010
- Author(s)
  松崎直子・西山眞理子・諸井佳代子・木村定雄
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-20590248

1. KIMURA Sadao (40134225)

# of Collaborated Projects: 11 results

# of Collaborated Products: 19 results
2. MOROI Kayoko (80110352)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. KASUYA Yoshitoshi (70221877)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. KADOTA Tomoko (00089864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. USUI Hirokazu (90375634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIYAUCHI Takashi (60222329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MATUDA Mituo (20110702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAIDO Takaomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NISHIYAMA Mariko 西山 眞理子

Research Projects

Research Products

Co-Researchers

A study on inhibitory regulation of urotensin II receptor signaling by RGS proteins: an attempt to find potential novel anti-arteriosclerotic agentsPrincipal Investigator

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血管収縮に関与する新しいエンドセリンB受容体サブタイプの特性と生理的意義Principal Investigator

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[Book] In silico search for biologically active peptides. in "Handbook of the Biologically Active Peptides", 2nd edition(edited by Kastin AJ)2013

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[Book] Handbook of the Biologically Active Peptides2013

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[Journal Article] Potent and selective inhibition of angiotensin AT1 receptor signalling by RGS2: roles of its N-terminal domain2011

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[Journal Article] Potent and selective inhibition of angiotensin AT1 receptor signalling by RGS2 : Roles of its N-terminal domain.2011

NISHIYAMA Mariko 西山眞理子

[Presentation] 血管作動性ペプチド受容体のカルシウム応答に対するRGS8の強力な抑制効果：　RGSドメインのC末端部分の重要性2014