TOMITA Toshio 冨田敏夫

… Alternative Names

富田敏夫トミタトシオ

Less

Researcher Number	00126129
Affiliation (based on the past Project Information) *help	2005: 東北大, (連合)農学研究科(研究院), 助教授 1998 – 2004: TOHOKU UNIV/GRADUATE SCHOOL OF AGRI.ASSIST.PROFESSOR, 大学院・農学研究科, 助教授 1995 – 1998: 東北大学, 農学部, 助教授 1992 – 1994: 東京大学, 医科学研究所, 講師 1987 – 1991: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / 細菌学 / Applied microbiology Except Principal Investigator 応用微生物学・応用生物化学 / 細菌学 / Digestive surgery / Applied microbiology
Keywords	Principal Investigator Staphylococcus aureus / 黄色ブドウ球菌 / γヘモリジン / ロイコシジン / リポソーム / 超分子 / 膜チャンネル / staphylococcal leukocidin / staphylococcal gamma-hemolysin / 膜孔 … More / 生体膜 / 担子菌 / subunit arrangement / electron microscopy / 3-dimensional structure / molecular architecture / transmembrane pore / two-component haemolysin / gamma-hemolysin / 二成分性溶血毒素 / 分子配列 / 電子顕微鏡 / 立体構造 / 分子構築 / 2成分性溶血毒素 / extracellular matrix / vitornectin / serum inhibitor / bi-component cytolysins / 細胞外マトリックス / ビトロネクチン / 阻害物質 / 2成分毒素 / neutrophil / erythrocyte / ring structure / complex formation / pore-forming toxin / bi-component cytolysin / リング状構造 / 膜孔複合体 / 膜孔形成 / 細胞崩壊毒素 / 二成分性毒素 / 複合体形成 / Liposome / Assembly / Binding / Pore-forming toxin / Alpha-toxin / チャンネル形成タンパク質 / ブドウ球菌 / タンパク質毒素 / 細胞膜 / 黄色ブドウ球菌α毒素 / オリゴマー / α毒素 / monoclonal antibody / membrane fluidity / transmembrane channel / liposome / membrane damage / alpha-toxin / 毒素六量体形成 / 膜障害機構 / モノクロ-ン抗体 / 溶血反応 / 膜の流動性 / 膜障害 / リポソ-ム / ブドウ球菌α毒素 / Pore形成 / 二成分細胞崩壊毒素 / ヒラタケ / 溶血毒素 / 膜チャネル / ヘモリジン / 溶血素 / タンパク質複合体 / 緑膿菌 / 溶血性タンパク質 … More Except Principal Investigator Staphylococcus aureus / γ-hemolysin / leukocidin / 黄色ブドウ球菌 / pore-forming toxin / 膜孔形成毒素 / ガンマヘモリジン / ロイコシジン / 膜孔形成 / phage conversion / staphylococcal gemone / 三次元構造 / 3次元構造 / digestive tract / feed supplement / bacterial infection / domestic animals / Stevia rebaudiana Bertoni / 予防 / 治療 / 細菌感染 / 病原菌 / 家畜 / 殺菌物質 / ステビア / Streptococcus mutans / AhpC / Immunoliposome / Thermal neutron / 中性子捕捉療法 / 熱中性子照射 / 硼素化合物 / 腸炎ビブリオ菌耐熱性溶血毒素 / 腸炎ビフリオ耐熱性溶血毒素 / ASO価測定法 / ストレプトリジンO / 腸炎ビブリオ耐熱性溶血毒素 / ブドウ球菌α毒素 / 膜障害 / リポソーム / 溶血毒素 / 細菌外毒素 / Recognition of target cells / Pore-foming mechanism / two-component hemolytic toxin / 一分子技術 / 標的細胞認識 / 膜孔形成機構 / 2成分性溶血毒素 / γ-ヘモリジン / Assembly of toxin components / Single-molecule imaging / staphylococcal toxin / gamma-hemolysin / 毒素成分集合 / 1分子イメージング / ブドウ球菌毒素 / growth promotion / fermehted extract / bactercidal substances / 増体促進 / 植物成分 / 3-dimensional structure / X線回折 / 2成分性毒素 / Hlg2 / LukF / g-hemolysin / LukS / LukF成分 / x線回折 / ビトロネクチン / ファージ変換 / fermentes extract / bactericidal substances / 殺菌感染 / 植物 / X-ray crystallography / Pore-forming toxin / Tow-component toxin / Staphylococcal gamma-hemolysine / Staphylococcal leukocidin / プロテインキナーゼA / ブドウ球菌 / 結晶解析 / 膜孔 / 二成分毒素 / X線結晶解析 / 血球崩壊毒素 / knockout mutants / oxidative stress / alkyl hydroperoxide reductase / ahpC gene / nox gene / NADH oxidase / NADH酸化 / 酸素ストレス / アルキルヒドロパーオキシドレダクターゼ / streptococcus mutans / 遺伝子破壊株 / AhpC遺伝子 / NADHオキシダーゼ遺伝子 / NADHオキシダーゼ / Anti-CEA monoclonal antibody / ^<10>B-compound / Boron neutron capture therapy (BNCT) / イムノリポソーム / 抗CEA単クローン抗体 / 熱中性子 / REGULATION / INVASION / PATHOGENICITY / SHIGELLA / 下痢 / プラスミド / VirB / 温度調節 / ビルレンス / 遺伝子発現 / 細胞侵入 / 細菌病原性 / 赤痢菌 / Anti CEA monoclonal antibody / Liposome / ^<10>B compound / Boron neutron capture therapy / 抗CEAモノクロナ-ル抗体 / 抗CEA単クロ-ン抗体 / リポソ-ム / 中性子捕促療法 Less

キノコに存在する膜孔形成タンパク質(ヘモリジン)の生理的意義に関する研究Principal Investigator
- Principal Investigator
  
  冨田敏夫
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  Tohoku University
Bacterial Two-component and Hetero-heptameric Pore-forming Cytolytic Toxins : Structures, Pore-forming Mechanism
- Principal Investigator
  
  KAMIO Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Tohoku University
Structural analysis of heteroheptamer transmembrane pore supramolecule of staphylococcal gamma-hemolysinPrincipal Investigator
- Principal Investigator
  
  TOMITA Toshio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tohoku University
Staphylococcal pore-forming toxins: Mechanism of pore-forming and recognition of the target cells
- Principal Investigator
  
  KAMIO Yoshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tohoku University
Bactericidal principle of the fermented aqueous extract of Stevia rebaudiana Bertoni and a possible use of the Stevia extract as a feed supplemen for prevention of the digestive tract infections.
- Principal Investigator
  
  KAMIO Yoshiyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tohoku University
A study on the inhibitory action of vitronnectin on staphylococcal leukocidin and gamma-hemolysinPrincipal Investigator
- Principal Investigator
  
  TOMITA Toshio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Graduate School of Agricultural Science, Tohoku University
Staphylococcal pore-forming toxins, g-hemolysin and leukocidin : Mechanism of pore-forming and expression of the toxins activities on the target cells
- Principal Investigator
  
  KAMIO Yoshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tohoku University
3-Dimensional structure of staphylococcal leukocidin and γ-hemolysin
- Principal Investigator
  
  KAMIO Yoshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tohoku University
Bactericidal principle of the fermented aqueous extract of Stevia rebaudiana Bertoni and a possible use of the Stevia extract as a feed supplement for prevention of the digestive tract infections
- Principal Investigator
  
  KAMIO Yoshiyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  TOHOKU UNIVERSITY
OXYGEN REGULATION OF NADH OXIDASE EXPRESSION IN STREPTOCOCCI
- Principal Investigator
  
  KAMIO Yoshiyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  TOHOKU UNIVERSITY
The mechanism of leukocytolysis and hemolysis of the Staphylococcal leukocidin and gamma-hemolysin
- Principal Investigator
  
  KAMIO Yoshiyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tohoku University
MODE OF ACTION OF STAPHYLOCOCCAL LEUKOCIDIN AND gamma-HEMOLYSINPrincipal Investigator
- Principal Investigator
  
  TOMITA Toshio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  FACULTY OF AGRICULTURE,TOHOKU UNIVERSITY
モデル膜を使用した溶血性タンパク質の膜チャンネル(超分子)形成機構の研究Principal Investigator
- Principal Investigator
  
  冨田敏夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
ブドウ球菌ロイコシジン及びγヘモリジンの血球識別機構の解析Principal Investigator
- Principal Investigator
  
  冨田敏夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tohoku University
モデル膜を使用した溶血性タンパク質の膜チャンネル(超分子)形成機構の研究Principal Investigator
- Principal Investigator
  
  冨田敏夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
モデル膜を使用した溶血性タンパク質の膜チャンネル(超分子)形成機構の研究Principal Investigator
- Principal Investigator
  
  冨田敏夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Assembly of Staphy lococcus aureus alpha-toxin on target membranesPrincipal Investigator
- Principal Investigator
  
  TOMITA Toshio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  The University of Tokyo
Analysis of molecular mechanisms of invasion of epithelial cells by Shigella
- Principal Investigator
  
  SASAKAWA Chihiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  The University of Tokyo
Application of monoclonal antibody against solid tumor to boron neutron capture therapy model
- Principal Investigator
  
  FUJII Yuzo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokyo
Study on the Membrane-damaging Action of Staphylococcal Alpha-toxin by use of Multilamellar Liposomes.Principal Investigator
- Principal Investigator
  
  TOMITA Toshio
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  The Institute of Medical Science, The University of Tokyo.
Application of Anti CEA-Immunoliposome to boron neutron capture therapy
- Principal Investigator
  
  FUJII Yuzo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The Institute of medical Science, University of Tokyo
モデル膜(リポソーム)を用いた蛋白質性溶血毒素の膜障害機構の解析
- Principal Investigator
  
  保田立二
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Okayama University
  The University of Tokyo

All 2004

All Journal Article

[Journal Article] Protein sequence analysis, cloning and expression of flammutoxin, a pore-forming cytolysin from Flammulina velutipes : Maturation of dimeric precursor to monomeric active form by carboxyl-terminal truncation.2004
- Author(s)
  Tomita, T., Mizumachi, Y., Chong, K, Ogawa, Konishi, Sugawara, Tomita, N, Dohmae, N, Hashimoto Y, Takio, K.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 54161-54172
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Protein sequence analysis, cloning an expression of flammutoxin a pore-forming cytolysin from Flammulina velutipes : Maturation of dimeric precursor to monomeric2004
- Author(s)
  Tomita, T., Mizumachi, Y, Chong, K, Ogawa, Konishi, Sugawara Tomita, N., Dohmae, N, Hashimoto Y, Takio
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 54161-54172
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex.2004
- Author(s)
  Tomita, T., Noguchi, K., Mimuro, H., Ukaji, F., Ito, K., Sugawara-Tomita, N., Hashimoto, Y.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 26975-26982
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Cloning, expression, and pore-forming properties of mature and precursor forms of pleurotolysin, a sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus.2004
- Author(s)
  Sakurai, N., Kaneko, J., Kamio., Y., Tomita, T.
- Journal Title
  
  Biochim.Biophys.Acta 1679
  
  Pages: 65-73
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Cloning, expression, and pore-forming properties of mature and precursor forms of pleurotolysin, a sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus.2004
- Author(s)
  Sakurai, N., Kaneko, J., Kamio., Y., Tomita, T.
- Journal Title
  
  Biochim.Biophys.Acta, 1679
  
  Pages: 65-73
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Protein sequence analysis, cloning and expression of flammutoxin, a pore-forming cytolysin from Flammulina velutipes : Maturation of dimeric precursor to monomeric active form by carboxyl-terminal truncation.2004
- Author(s)
  Tomita, T., Mizumachi, Y, Chong, K, Ogawa., Konishi, Sugawara Tomita, N., Dohmae, N, Hashimoto, Y., Takio, K.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 54161-54172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Cloning expression, and pore-forming properties of mature and precursor forms of pleurotolysin, a sphingomyelin-specific two-component cytolysin from the edible2004
- Author(s)
  Sakurai, N., Kaneko, J., Kamio, Y., Tomita, T.
- Journal Title
  
  Biochim.Biophys.Acta 1679
  
  Pages: 65-73
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Effect of a pore-forming protein derived from Flammulina velutipes on the Caco-2 intestinal epithelial cell monolayer.2004
- Author(s)
  Narai, A., Watanabe, H., Iwanaga, T., Tomita, T., Shimizu, M.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 68
  
  Pages: 2230-2238
- NAID
  130000030909
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembled into a transmembrane pore complex.2004
- Author(s)
  Tomita, T., Noguchi, K., Mimuro, H., Ukaji, F., Ito, K., Sugawara-Tomita, N., Hashimoto, Y.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 26975-26982
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590380
[Journal Article] Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex.2004
- Author(s)
  Tomita, T., Noguchi, K.Mimuro, H.Ukaji, F.Ito, K., Sugawara-Tomita, N., Hashimoto, Y.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 26975-26982
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590380

1. KAMIO Yoshiyuki (00109175)

# of Collaborated Projects: 12 results

# of Collaborated Products: 3 results
2. KANEKO Jun (30221188)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. FUJII Yuzo (40143515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOBAYASHI Hisao (10062605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NARIUCHI Hideo (10012741)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ABE Naoki (90202671)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HIGUCHI Hideo (90165093)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SHIRAISHI Hiroyuki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SEKIGUCHI Morimasa (60012712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SASAKAWA Chihiro (70114494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TOBE Toru (70207596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YANAGIE Hironobu (30212278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 高橋司 (90143510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 福田一郎 (10242108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 森茂郎 (30010424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 保田立二 (30092357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 平山壽哉 (50050696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SAEGUSA Yoshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. POOLE Leslie B.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. CLAIBORNE Al

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SATO Naohiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. UGA Toshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 成谷宏文

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOMITA Toshio 冨田 敏夫

富田 敏夫 トミタ トシオ

Research Projects

Research Products

Co-Researchers

キノコに存在する膜孔形成タンパク質(ヘモリジン)の生理的意義に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural analysis of heteroheptamer transmembrane pore supramolecule of staphylococcal gamma-hemolysinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the inhibitory action of vitronnectin on staphylococcal leukocidin and gamma-hemolysinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MODE OF ACTION OF STAPHYLOCOCCAL LEUKOCIDIN AND gamma-HEMOLYSINPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モデル膜を使用した溶血性タンパク質の膜チャンネル(超分子)形成機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ブドウ球菌ロイコシジン及びγヘモリジンの血球識別機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TOMITA Toshio 冨田敏夫

富田敏夫トミタトシオ