HIRAYAMA Toshiya 平山壽哉

Researcher Number	50050696
Other IDs
External Links
Affiliation *help	1993 – 2014 : 長崎大学, 熱帯医学研究所, 教授 1992 : 東京大学, 医科学研究所, 助教授 1986 – 1990 : Thi Institute of Medical Science, The University of Tokyo, 医科学研究所, 助教授 1986 : 東大, 医科学研究所, 助教授
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / 細菌学 / Biological Sciences Except Principal Investigator 細菌学 / Bacteriology (including Mycology) / Bacteriology (including Mycology) / Environmental physiology (including Physical medicine and Nutritional physiology) / Gastroenterology
Keywords	Principal Investigator 細菌毒素 / VacA / ヘリコバクター・ピロリ / 毒性発現 / 毒素受容体 / 空胞化毒素 / ヘリコバクター / 下痢毒素 / VacA毒素 / レセプター … More Except Principal Investigator Helicobacter pylori / VIP / bead-ELISA / Ionto-phrosis / nude-SCID Mouse / VT1 / VT2 / 腸管出血性大腸菌 / VT2vh / Salmonella oranienburg / アドレナリン / 志賀毒素様毒素 / 0139 / RNA Nーグリコシダーゼ / 腸管感染症 / VT2 variant / キャンピロバクタ・ジェシュニ / New cholera Vibrio / 腸炎ビブリオ耐熱性溶血毒素 / レセプター / 小児 / ワクチン / ASO価測定法 / 志賀毒素 / H. pylori / カテコールアミン / Human skin transplantation / Vero毒素 / Vero toxin / 抗原タンパク質 / 腸炎ビブリオ菌耐熱性溶血毒素 / 細菌 / ブドウ球菌α毒素 / RPTP β / 膜障害 / 東南アジア / コレラ毒素 / アセチール・コリン / Virulence factor / QSART(Quantative Sudo-Motor Axon Reflex) / 病原性 / cloning / CagA / 抗H. pylori抗体 / 発汗研究法 / Salmonella Oranienburg / Method on research for sweating / 血清抗体 / 高感度ELISA法 / 血清 / 抗原解析 / インド / 細菌外毒素 / コレラ菌0139ベンガル型 / O139ベンガル型 / 生菌ワクチン / 代射調節 / 新型コレラ菌 / 溶血毒素 / 下痢原因毒素 / エンテロトキシン / ピロカルピン / 腸炎ビフリオ耐熱性溶血毒素 / カルシウムイオン / 疫学 / コバルト60照射 / Epidemiology / ricin / ヘリコバクター・ピロリ / QSART (Quantative Sudo-Motor Axon Reflex) / タイ王国 / Catecholamine / Salmonella enteritidis / 抗原変換 / ヒト皮膚移植 / RPTPβ / 抗体 / モルヒネ / プロテオミクス / 腸管感染 / リポソーム / RNAーNーglycosidase / Intestinal Infection / 弱免疫マウス / STEC / パルスフィールドゲル電気泳動 / O139ベンガル / 蛋白合成阻害 / アジュバンド / 大腸菌エンテロトキシン / 病原因子 / O139 Bengal / 死菌ワクチン / 耐熱性エンテロトキシン(ST) / Cholera-like toxin / 経口コレラワクチン / Week immune mouse / 細胞致死毒素 / Vaccine / RFLP / VIP(vaso-active intestinal polypeptide) / Co60 irradiation / morphine / ストレプトリジンO / クローニング / Campylobacter Jejuni / Southeast Asia / 粘膜免疫 / Bacteria / Pathogenicity Less

Anti-Helicobacter pylori antibody succession during gastric carcinogenesis monitored with proteomics and antigen-chip analysis
- Principal Investigator
  
  AKADA Junko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamaguchi University
Analysis of gene expression of Helicobacter pylori VacAPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Analysis on multifunctional receptors for Helicobacter pylori VacAPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
ヘリコバクター・ピロリVacA毒素の毒性発現機序Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
ヘリコバクター・ピロリVacA毒素の毒性発現機序Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Toxicity of Helicobacter pylori VacA and its mutual effect with CagAPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Comparison of virulence factors produced by Helicobacter pylori between Philippine and ThailandPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Study on the function of receptor for Helicobacter pylori VacA and the mechanism of its intoxicationPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Mechanism of Helicobacter pylonVacAintoxicationPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Surveillance of Bacterial Intestinal diseases in Southeast Asian countries
- Principal Investigator
  
  KURAZONO Hisao
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka Prefecture University
  Okayama University
ピロリ菌空胞化毒素を阻害する血清成分に関する研究Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
ヘリコバクター・ピロリVacA毒素の空胞致死活性機序Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Research for comparison of VacA in H. pylori infectious diseasesPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
ヘリコバクター・ピロリVacA毒素の空胞致死活性機序Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Basic research for H. pylori component vaccinePrincipal Investigator
- Principal Investigator
  
  HITAYAMA Toshiya
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Analysis of bacterial infectious-pathogens in Japan and Asian countries.
- Principal Investigator
  
  KURAZONO Hisao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  OKAYAMA UNIVERSITY
TOXICITY OF HELICOBACTER PYLORI VACA TOXIN THROUGH ITS CELLULAR RECEPTORPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  NAGASAKI UNIVERSITY
RECEPTOR OF HELICOBACTER PYLORI VACA TOXIN AND ITS SIGNAL FOR TOXIXITYPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  NAGASAKI UNIVERSITY
ADP-RIBOSYLTRANSFERASE OF HELIOBACTER PYLORIPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
ENTEROTOXICITY OF HEAT-STABLE ENTEROTOXIN PRODUCED FROM ENTEROTOXIGENIC ESCHERICHIA COLIPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  NAGASAKI UNIVERSITY
Study on sweating from xenotransplanted human skin
- Principal Investigator
  
  KOSAKA Mitsuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Nagasaki University
毒素原性大腸菌の耐熱性エンテロトキシンの受容体活性化Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Deparment of vaccine for new type of Vibrio cholerae O139 Bengal
- Principal Investigator
  
  TAKEDA Yoshifumi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Research Institute, International Medical Center of Japan
毒素原性大腸菌の耐熱性下痢毒素の受容体活性化Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
毒素原性大腸菌の耐熱性下痢毒素のグアニル酸シクラーゼ活性化機構Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  1993 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
毒素原性大腸菌耐熱性下痢毒素の受容体の毒素結合部位Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  The University of Tokyo
毒素原性大腸菌耐熱性下剤毒素の受容体の構造と機能Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  The University of Tokyo
毒素原性大腸菌耐熱性下痢毒素の受容体とグアニレ-トシクラ-ゼ活性化機構Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  The University of Tokyo
Study on Structure and function of enterotoxins
- Principal Investigator
  
  TAKEDA Yoshifumi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  細菌学
- Research Institution
  Institute of Medical Science, University of Tokyo
モデル膜(リポソーム)を用いた蛋白質性溶血毒素の膜障害機構の解析
- Principal Investigator
  
  保田立二
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Okayama University
  The University of Tokyo
Bacterial enterotoxin receptor and its signal transductionPrincipal Investigator
- Principal Investigator
  
  TOSHIYA Hirayama
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  The University of Tokyo
コレラ毒素及び大腸菌エンテロトキシンによる下痢活性のカルシウムイオンによる調節
- Principal Investigator
  
  TAKEDA Yoshifumi
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
病原性大腸菌が産生する新しいVero細胞毒素およびCHO細胞毒素の研究Principal Investigator
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  The University of Tokyo
Studies of Pathogenicity of Campylobacter jejuni.
- Principal Investigator
  
  TAKEDA Yoshifumi
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  The Institute of Medical Science, The University of Tokyo
  Osaka University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] 生物資源としての細菌毒素2009
- Author(s)
  平山壽哉, 中山真彰, 久恒順三
- Publisher
  微生物資源国際戦略ガイドブック
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets.2015
- Author(s)
  Kazama F, Nakamura J, Osada M, Inoue O, Oosawa M, Tamura S, Tsukiji N, Aida K, Kawaguchi A, Takizawa S, Kaneshige M, Tanaka S, Suzuki-Inoue K (corresponding author), Yukio Ozaki.
- Journal Title
  
  Thromb J.
  
  Volume : in press Pages : 23-30
- DOI
  10.1186/1477-9560-11-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461399, KAKENHI-PROJECT-23591378, KAKENHI-PROJECT-24659199
[Journal Article] Helicobacter pyloriの病原因子2013
- Author(s)
  中野政之，八尋錦之助　平山壽哉
- Journal Title
  
  臨床と微生物
  
  Volume : 40 Pages : 178-181
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] 連載・私達の研究: ピロリ菌感染における vacuolating cytotoxin (VacA)の役割に関する研究2013
- Author(s)
  平山壽哉、中野政之
- Journal Title
  
  化学療法の領域
  
  Volume : 29 Pages : 117-123
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-induced Apoptosis2013
- Author(s)
  Akazawa Y, Isomoto H, Matsushima K, Kanda T, Minami H, Yamaghchi N, Taura N, Shiozawa K, Ohnita K, Takeshima F, Nakano M, Moss J, Hirayama T, Nakao K.
- Journal Title
  
  PLoS One
  
  Volume : 8(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] 連載・私達の研究ピロリ菌感染におけるvacuolating cytotoxin(VacA)の役割に関する研究2013
- Author(s)
  平山壽哉、中野政之
- Journal Title
  
  化学療法の領域
  
  Volume : vol.29(12) Pages : 117-123
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis.2013
- Author(s)
  Akazawa Y, Isomoto H, Matsushima K, Kanda T, Minami H, Yamaghchi N, Taura N, Shiozawa K, Ohnita K, Takeshima F, Nakano M, Moss J, Hirayama T, Nakao K.
- Journal Title
  
  PLoS One.
  
  Volume : 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] ピロリ菌の空胞化毒素VacAの病原性に関する新たな洞察2013
- Author(s)
  中野政之、平山壽哉
- Journal Title
  
  日本ヘリコバクター学会誌
  
  Volume : vol.15 Pages : 12-21
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] Helicobacter pyloriの病原因子2013
- Author(s)
  中野政之,八尋錦之助平山壽哉
- Journal Title
  
  臨床と微生物
  
  Volume : vol.40 Pages : 178-181
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets2013
- Author(s)
  Satoh K, Hirayama T, Takano K, Suzuki-Inoue K, Sato T, Ohta M, Nakagomi J, Ozaki Y.
- Journal Title
  
  Thromb J
  
  Volume : 11 Pages : 23-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection2012
- Author(s)
  Isomoto H, Matsushima K, Inoue N, Hayashi T, Nakayama T, Kunizaki M, Hidaka S, Nakayama M, Hisatsune J, Nakashima M, Nagayasu T, Nakao K, Hirayama T.
- Journal Title
  
  J Clin Immunol
  
  Volume : 32 Pages : 290-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] Salmonella enterotoxin (Stn) regulates membrane composition and integrity2012
- Author(s)
  Nakano M, Yamasaki E, Ichinose A, Shimohata T, Takahashi A, Akada JK, Nakamura K, Moss J, Hirayama T, Kurazono H.
- Journal Title
  
  Dis Model Mech
  
  Volume : 5 Pages : 515-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] Low-densityLipoprotein Receptor-related Protein-1 (LRP1) Mediates Autophagy and ApoptosisCaused by Helicobacter pylori VacA2012
- Author(s)
  Yahiro K, Satoh M, Nakano M, Hisatsune J, Isomoto H, Sap J, Suzuki H, Nomura F, Noda M, Moss J, Hirayama T.
- Journal Title
  
  J Biol Chem
  
  Volume : 287 Pages : 3104-3115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells2012
- Author(s)
  Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, Nagano O, Matsuzaki J, Hibi T.
- Journal Title
  
  Cell Host Microbe
  
  Volume : 12 Pages : 764-777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659199
[Journal Article] Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pyloriCagA Is Specifically Suppressed in Cancer Stem-like Cells.2012
- Author(s)
  Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, Nagano O, Matsuzaki J, Hibi T
- Journal Title
  
  Cell Host Microbe
  
  Volume : 12 Pages : 764-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Low-density Lipoprotein Receptor-related Protein-1 (LRP1) Mediates Autophagy and Apoptosis Caused by Helicobacter pyloriVacA2012
- Author(s)
  Yahiro K, Satoh M, Nakano M, Hisatsune J, Isomoto H, Sap J, Suzuki H, Nomura F, Noda M, Moss J, Hirayama T.
- Journal Title
  
  J Biol Chem.
  
  Volume : 287 Pages : 3104-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Salmonella enterotoxin (Stn) regulates membrane composition and integrity2012
- Author(s)
  Nakano M, Yamasaki E, Ichinose A, Shimohata T, Takahashi A, Akada JK, Nakamura K, Moss J, Hirayama T, Kurazono H.
- Journal Title
  
  Dis Model Mech
  
  Volume : 5 Pages : 515-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection.2012
- Author(s)
  Isomoto H, Matsushima K, Inoue N, Hayashi T, Nakayama T, Kunizaki M, Hidaka S, Nakayama M, Hisatsune J, Nakashima M, Nagayasu T, Nakao K, Hirayama T.
- Journal Title
  
  J Clin Immunol
  
  Volume : 32 Pages : 290-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] MicroRNA signatures in Helicobacter pylori-infected gastric mucosa2011
- Author(s)
  Matsushima K, Isomoto H, Inoue N, Nakayama T, Hayashi T, Nakayama M, Nakao K, Hirayama T, Kohno S.
- Journal Title
  
  Int .J. Cancer
  
  Volume : 128 Pages : 361-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Enhanced Expression of CXCL13 in Human Helicobacter pylori-Associated Gastritis2011
- Author(s)
  Nakashima Y, Isomoto H, Matsushima K, Yoshida A, Nakayama T, Nakayama M, Hisatsune J, Ichikawa T, Takeshima F, Hayashi T, Nakao K, Hirayama T, Kohno S
- Journal Title
  
  Dig Dis Sci
  
  Volume : 56 Pages : 2887-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Helicobacter pylori VacA reduces cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells.2011
- Author(s)
  Matsumoto A, Isomoto H, Nakayama M, Hisatsune J, Nishi Y, Nakashima Y, Matsushima K, Kurazono H, Nakao K, Hirayama T, and Kohno S
- Journal Title
  
  Dig. Dis. Sci.
  
  Volume : 56 Pages : 999-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.2010
- Author(s)
  Isomoto H, Moss J, Hirayama T.
- Journal Title
  
  Tohoku J Exp Med. 220
  
  Pages : 3-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] MicroRNA signatures in Helicobacter pylori-infected gastric mucosa.2010
- Author(s)
  Matsushima K, Isomoto H, Inoue N, Nakayama T, Hayashi T, Nakayama M, Nakao K, Hirayama T, Kohno S.
- Journal Title
  
  Int J Cancer (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin,VacA.2010
- Author(s)
  Isomoto H, Moss J, Hirayama T.
- Journal Title
  
  Tohoku J. Exp. Med
  
  Volume : 220 Pages : 3-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells.2010
- Author(s)
  Akada JK, Aoki H, Torigoe Y, Kitagawa T, Kurazono H, Hoshida H, Nishikawa J, Terai S, Matsuzaki M, Hirayama T, Nakazawa T, Akada R, Nakamura K.
- Journal Title
  
  Dis. Model. Mech
  
  Volume : 3 Pages : 605-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p212010
- Author(s)
  Saito Y, Murata-Kamiya N, Hirayama T,Ohba Y, Hatakeyama M
- Journal Title
  
  J. Exp. Med
  
  Volume : 207 Pages : 2157-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390084
[Journal Article] Helicobacter pylori-Induced Interleukin-12 p40 Expression.2009
- Author(s)
  Takeshima E, Tomimori K, Teruya H, Ishikawa C, Senba M, D'Ambrosio D, Kinjo F, Mimuro H, Sasakawa C, Hirayama T, Fujita J, Mori N.
- Journal Title
  
  Infect. Immun. 77
  
  Pages : 1337-1348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Helicobacter pylori VacA activates NF-kappaB in T cells via the classical but not alternative pathway.2009
- Author(s)
  Takeshima E, Tomimori K, Takamatsu R, Ishikawa C, Kinjo F, Hirayama T, Fujita J, Mori N.
- Journal Title
  
  Helicobacter 14
  
  Pages : 271-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis.2009
- Author(s)
  Yoshida A, Isomoto H, Hisatsune J, Nakayama M, Nakashima Y, Matsushima K, Mizuta Y, Hayashi T, Yamaoka Y, Azuma T, Moss J, Hirayama T, Kohno S.
- Journal Title
  
  Clin Immunol 130
  
  Pages : 290-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.2009
- Author(s)
  Nakayama M, Hisatsune J, Yamasaki E, Isomoto H, Kurazono H, Hatakeyama M, Azuma T, Yamaoka Y, Yahiro K, Moss J, Hirayama T.
- Journal Title
  
  J Biol Chem. 284
  
  Pages : 1612-1619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] ピロリ菌空胞化毒素の多機能性-感染における役割-2009
- Author(s)
  山崎栄樹, 磯本一, 平山壽哉
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages : 607-613
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Molecular characterization of Helicobacter pylori VacA-induction of IL-8 in U937 cells reveals a prominent role for p38MAP kinase in ATF-2, CREB and NF-kB activation.2008
- Author(s)
  Hisatsune J, Nakayama M, Isomoto H. Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yahiro K, Moss J, Hirayama T.
- Journal Title
  
  J. Immunol 180
  
  Pages : 5017-5027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Helicobacter pyloriVacAに関する最近の研究動向とわれわれの取り組み2008
- Author(s)
  平山壽哉, 久恒順三, 中山真彰, 山崎栄樹
- Journal Title
  
  Helicobacter Research 12
  
  Pages : 266-271
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Involvement of VAMP7 in human gastric epithelial cell vacuolation induced by Helicobacter pylori-produced VacA.2008
- Author(s)
  Mashima H, Suzuki J, Hirayama T, Yoshikumi Y, Ohno H, Ohnishi H, Yasuda H, Fujita T, Omata M
- Journal Title
  
  Infect. Immun 76
  
  Pages : 2296-2303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] Helicobacter pylori Infection(in Japanses)2007
- Author(s)
  Hirayama, T
- Journal Title
  
  Igakuno Ayumi 223
  
  Pages : 623-627
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18406015
[Journal Article] 変貌する細菌感染症:Helicobacter pylori感染症2007
- Author(s)
  平山壽哉
- Journal Title
  
  医学のあゆみ 223
  
  Pages : 623-627
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18406015
[Journal Article] Helicobacter pylori VacA enhances PGE2 production through induction of COX-2 expression via a p38 MAP kinase/ATF-2 cascade in AZ-521 cells.2007
- Author(s)
  Hisatsune J, Yamasaki E, Nakayama M, Shirasaka D, Kurazono H, Katagata Y, Inoue H, Han J, Sap J, Yahiro K, Moss J, Hirayama T
- Journal Title
  
  nfect. Immun. 75
  
  Pages : 4472-4481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] 変貌する細菌感染症:Helicobacter pylori感染症2007
- Author(s)
  平山壽哉
- Journal Title
  
  医学のあゆみ 223
  
  Pages : 623-627
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article]2007
- Author(s)
  平山壽哉
- Journal Title
  
  医学のあゆみ 223
  
  Pages : 623-627
- Data Source
  KAKENHI-PROJECT-18406015
[Journal Article] 変貌する細菌感染症: Helicobacter pylori 感染症2007
- Author(s)
  平山壽哉
- Journal Title
  
  医学のあゆみ 223
  
  Pages : 623-627
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] ヘリコバクター・ピロリのVacA毒素受容体と毒性発現に関する研究2007
- Author(s)
  平山壽哉
- Journal Title
  
  日本細菌学雑誌 62
  
  Pages : 387-396
- Data Source
  KAKENHI-PROJECT-19209014
[Journal Article] 変貌する細菌感染症: Helicobacter pylori感染症2007
- Author(s)
  平山壽哉
- Journal Title
  
  医学のあゆみ 223
  
  Pages : 623-627
- Data Source
  KAKENHI-PROJECT-19041060
[Journal Article] Helicobacter pylori VacA clustering in lipid rafts, mediated by receptor, RPTP β, is required for intoxication in AZ-521 cells.2006
- Author(s)
  Nakayama M, Hisatsune J, Yamasaki E, Nishi Y, Wada A, Kurazono H, Sap J, Yahiro K, Moss J, Hirayama T
- Journal Title
  
  Infect Immun 74
  
  Pages : 6571-6580
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209015
[Journal Article] Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic protein Bax, leading to cytochrome c release and cell death, independent of vacuolation2006
- Author(s)
  Yamasaki E., Wada A., Kumatori A., Nakagawa I., Funao J., Nakayama M., Hisatsune J., Kimura M., Moss J., Hirayama T.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages : 11250-11259
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209015
[Journal Article] Endoscope disinfection using chlorine dioxide in an automated washer-disinfector.2006
- Author(s)
  Isomoto H., Urata M, Kawazoe K, Matsuda J, Nishi Y, Wada A, Ohnita K, Hirakata Y, Matsuo N, Inoue K, Hirayama T, Kamihira S, Kohno S.
- Journal Title
  
  J. Hosp. Infect 63
  
  Pages : 298-305
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209015
[Journal Article] Helicobacter pylori vacuolating cytotoxin induces activation of the proapototic protein Bax, leading to cytochrome c release and cell death, independent of vacuolation.2006
- Author(s)
  Yamasaki, E., Hirayama, T.et al.
- Journal Title
  
  J.Biol.Chem. (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Vacuolating cytotoxin A is associated with increased thrombin generation in gastric mucosa.2006
- Author(s)
  Suzuki, Y., Hirayama, T.et al.
- Journal Title
  
  Helicobacter (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Helicobacter pylori vacuolating cytotoxin induces activation of the proapototic protein Bax, leading to cytochrome c release and cell death, independent of vacuolation.2006
- Author(s)
  Yamasaki, E., Hirayama, T.et al.
- Journal Title
  
  J.Biol.Chem. 印刷中
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic protein Bax, leading to cytochrome C release and cell death, independent of vacuolation.2006
- Author(s)
  Yamasaki, E., Hirayama, T.et al.
- Journal Title
  
  J.Biol.Chem. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic protein Bax, leading to cytochrome c release and cell death, independent of vacuolation2006
- Author(s)
  Yamasaki E., Wada A., Kumatori A., Nakagawa I., Funao J., Nakayama M., Hisatsune J., Kimura M., Moss J., Hirayama T.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages : 11250-11259
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16017280
[Journal Article] Functional antagonism between Helicobacter pylori CagA and VacA in control of the NFAT signaling pathway in gastric epitherial cells.2005
- Author(s)
  Yokoyama, K., Hirayama, T.et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 102
  
  Pages : 9661-9666
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] High concentrations of human beta-defensin 2 in gastric juice of patients with Helicobacter pylori infection.2005
- Author(s)
  Isomoto, H., Hirayama, T.et al.
- Journal Title
  
  World J.Gastroenterol. 11
  
  Pages : 4782-4787
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxin.2005
- Author(s)
  Yahiro, K., Hirayama, T.et al.
- Journal Title
  
  Helicobacter 11
  
  Pages : 4782-4787
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Functional antagonism between Helicobacter pylori CagA and VacA in control of the NFAT signaling pathway in gastric epithelial cells.2005
- Author(s)
  Yokoyama, K., Hirayama, T.et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 102
  
  Pages : 9661-9666
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPa and RPTPb, by Helicobacter pylori m2 VacA.2005
- Author(s)
  De Guzman, B.B., Hirayama, T.et al.
- Journal Title
  
  Cell Microbiol. 7
  
  Pages : 1285-1293
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPa and RPTPb, Helicobacter pylori m2 VacA.2005
- Author(s)
  De Guzman, B.B., Hirayama, T.et al.
- Journal Title
  
  Cell Microbiol. 7
  
  Pages : 1285-1293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxin.2005
- Author(s)
  Yahiro, K., Hirayama, T.et al.
- Journal Title
  
  Helicobacter 10
  
  Pages : 231-239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] High concentration of human beta-defensin 2 in gastric juice of patients with Helicobacter pylori infection.2005
- Author(s)
  Isomoto, H., Hirayama T.et al.
- Journal Title
  
  World J.Gastroenterol. 11
  
  Pages : 4782-4787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Vacuolating cytotoxin A is associated with increased thrombin generation in gastric mucosa.2005
- Author(s)
  Suzuki, Y., Hirayama, T.et al.
- Journal Title
  
  Helicobacter 10
  
  Pages : 323-331
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPa and RPTPO, by Helicobacter pylori m2VacA.2005
- Author(s)
  De Guzman, B.B., Hisatsune, J., Nakayama, M., Yahiro, K., Wada, A., Yamasaki, E., Nishi, Y., Yamazaki, S., Azuma, T., Ito, Y., Ohtani, M., van der Wijk, T., den Hertog, J., Moss, M., Hirayama T.
- Journal Title
  
  Cell Microbiol 7
  
  Pages : 1285-293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16017280
[Journal Article] Functional antagonism between Helicobacter pylori CagA and VacA in control of the NFAT signaling pathway in gastric epithelial cells2005
- Author(s)
  Yokoyama, K., Higashi, H., Ishikawa, S., Fujii, Y., Kondo, S., Kato, H., Azuma, T., Wada, A., Hirayama, T., Aburatani, H., Hatakeyama, M.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA. 102
  
  Pages : 9661-9666
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16017280
[Journal Article] Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxin.2005
- Author(s)
  Yahiro K, Shirasaka D, Tagashira M, Wada A, Morinaga N, Kuroda F, Choi 0, Inoue M, Aoyama N, Ikeda M, Hirayama T, Moss J, Noda M.
- Journal Title
  
  Helicobacter. 10
  
  Pages : 231-239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16017280
[Journal Article] Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.2005
- Author(s)
  Wada, A., Hirayama, T.et al.
- Journal Title
  
  Int.J.Med.Microbiol. 294
  
  Pages : 427-435
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Concentration of alpha- and beta-defensins in gastric juice of patients with various gastroduodenal diseases.2005
- Author(s)
  Nishi, Y., Hirayama, T.et al.
- Journal Title
  
  World J.Gastroenterol. 11
  
  Pages : 99-103
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406013
[Journal Article] Helicobacter pylori VacA activates the p38/ATF-2-mediated signal pathway in AZ-521 cells.2004
- Author(s)
  Nakayama, M., Kimura, M., Wada, A., Yahiro, K., Ogushi, 'K., Niidome, T., Fujikawa, A., Shirasaka, D., Aoyama, N., Kurazono, H., Noda, M., Moss, J., Hirayama, T.
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages : 7024-7028
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16017280
[Journal Article] Essential domain of receptor tyrosine phosphatase 3, RPTP0, for interaction with Helicobacter pylori vacuolating cytotoxin.2004
- Author(s)
  Yahiro, K., Wada, A., Yamasaki, E., Nakayama, M., Nishi, Y., Hisatsune, J., Morinaga, N., Sap, J., Noda, M., Moss, J., Hirayama, T.
- Journal Title
  
  J. Biol. Chem. 299
  
  Pages : 51013-51021
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16017280
[Presentation] ピロリ菌が産生するVacAはRPTPαを介してc-Srcを活性化する2014
- Author(s)
  中野政之、八尋錦之助、久恒順三、赤田純子、野田公俊、平山壽哉
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] ピロリ菌がん蛋白質CagAを分解するオートファージを誘導するLRP1シグナル2014
- Author(s)
  津川仁、鈴木秀和、佐藤聡、三好佐和子、森英毅、正岡建洋、金井隆典、水島徹、井本正哉、平山壽哉
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] LRP-1 mediates autophagy and apoptosis caused by Helicobacter pylori vacuolating cytotoxin, VacA2013
- Author(s)
  Hirayama T, Nakano M, Noda M, Yahiro K
- Organizer
  XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  Facultad de Medicina de la Universidad Autonoma de Madrid,Madrid, スペイン
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] AUTOPHAGY CAUSING CAGA DEGRADATION IS TRIGGERED BY CYTOPLASMIC ACCUMULATION OF LOW-DENSITY LIPOPROTEIN RESEPTOR-RELATED PROTEIN-1(LRP1)IN GASTRIC EPITHELIAL CELLS INFECTED WITH H.PYLORI.2013
- Author(s)
  Tugawa H., Matsuzaki J., Okada S., Fukuhara S., Mori H., Masaoka T., Sato A., Saya H., Hatakeyama M., Hirayama T., Suzuki H.
- Organizer
  Unites European Gastoroenterogy Week Berin 2013
- Place of Presentation
  Internationales Congress Centrum Berlin,Belrin, ドイツ
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Low-density lipoprotein receptor-related protein-1 (LRP-1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA.2013
- Author(s)
  Hirayama T., Yahiro K., Nakano M., Noda M., Moss J.
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  MiCo - Milano Congressi, Milan, イタリア
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Identification of helicobacter pylori VacA in human lung and its effects on airway epitelial cells2013
- Author(s)
  Nakashima S., Kakugawa T., Harada T., Hara S., Sakamoto N., Nakano M., Ishimatsu Y., Isomoto H., Mukae H., Kurazono H., Hirayama T., Kohno S.
- Organizer
  ERS Annual Congress2013
- Place of Presentation
  FIRA BARCELONA, Barcelona, スペイン
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Helicobacter pylori VacA cause autophagy and apoptosis Low-density lipoprotein receptor-related protein-1(LRP-1)2013
- Author(s)
  Hirayama T.
- Organizer
  The 5th Congress of European Microbiologists　(FEMS 2013)
- Place of Presentation
  Leipziger Messe GmbH, Leipzig, ドイツ
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] H.pylori感染胃粘膜の背景 : miRNA発現変動と炎症2013
- Author(s)
  松島加代子、磯本一、赤澤祐子、大仁田賢、平山壽哉
- Organizer
  第19回日本ヘリコバクター学会学術集会
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] 細胞内CagA安定性を規定する細胞表層LRP1のautophagy制御機構2013
- Author(s)
  津川仁、鈴木秀和、佐谷秀行、松崎潤太郎、平田賢郎、福原誠一郎、岡田佐和子、正岡建洋、畠山昌則、平山壽哉、日比紀文
- Organizer
  第19回日本ヘリコバクター学会学術集会
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Identification of Helicobacter pylori VacA in human lung and its effects on airway epitelial cells2013
- Author(s)
  Nakashima S., Kakugawa T., Harada T., Hara S., Sakamoto N., Nakano M., Ishimatsu Y., Isomoto H., Mukae H., Kurazono H., Hirayama T., Kohno S.
- Organizer
  ERS Annual Congress 2013
- Place of Presentation
  Barcelona
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Low-density lipoprotein receptor-related protein-1 (LRP-1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA2013
- Author(s)
  Hirayama T., Yahiro K., Nakano M., Noda M., Moss J.
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Hellcobacter pylori VacA cause autophagy and apoptosis Low-densitylipoprotein receptor-related protein-1 (LRP-1)2013
- Author(s)
  Hirayama T.
- Organizer
  5th Congress of European Microbiologists (FEMS 2013)
- Place of Presentation
  Leipzig
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] VacAは小胞体ストレスの活性化により胃上皮細胞にアポトーシスを誘導する2013
- Author(s)
  赤澤祐子、磯本一、松島加代子、南ひとみ、山口直之、塩澤健、大仁田賢、竹島史直、平山壽哉、中尾一彦
- Organizer
  第19回日本ヘリコバクター学会学術集会
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] ヘリコバクター・ピロリVacAのLRP1を介したオートファジーとアポトーシス誘導2013
- Author(s)
  八尋錦之助、中野政之、野田公俊、平山壽哉
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張市
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] LRP-1 mediates autophagy and apoptosis caused by Helicobacter pylori vacuolating cytotoxin2013
- Author(s)
  Hirayama T, Nakano M, Noda M, Yahiro K.
- Organizer
  XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer, VacA
- Place of Presentation
  Madrid
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] 胃MALTリンパ腫における拡大内視鏡所見の検討2013
- Author(s)
  松島加代子、磯本一、赤澤祐子、大仁田賢、中尾一彦、平山壽哉
- Organizer
  第19回日本ヘリコバクター学会学術集会
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] ヘリコバクター・ピロリ感染症と毒素病態学的研究アプローチ2012
- Author(s)
  平山壽哉
- Organizer
  第86回日本感染症学会総会
- Place of Presentation
  長崎市
- Year and Date
  2012-04-26
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Salmonella Stn regulates membrane composition and integrity2012
- Author(s)
  Masayuki Nakano, Toshiya Hirayama
- Organizer
  The 6th Nagasaki Symposium on Tropical and Emerging Infectious Diseases & The 11thNagasaki-Singapore Medical Symposium
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] A new insight into the function of of Stn roduced by Salmonella2012
- Author(s)
  Nakano M., Yamasaki E., Shimohata T., Takahashi A., Moss J., Kurazono, H., Hirayama T.
- Organizer
  ASM2012 112th General Meeting
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Salmonella Stn regulates membrane composition and integrity2012
- Author(s)
  Toshiya Hirayama and Masayuki Nakano
- Organizer
  14th International Symposium on Microbial Ecology
- Place of Presentation
  Copenhagen
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] ER stress contributes to VacA induced gastric epithelial cell death2012
- Author(s)
  Akazawa Y., Isomoto H., Matsushima K., Shiozawa K., Yamaguchi N., Ohnita K., Takeshima F., Hirayama T., Nakao K.
- Organizer
  UEGW 2012
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Low-densitylipoprotein receptor-related protein-1 (LRP-1) mediates autophagy and apoptosis caused by Helicobacterpylori VacA2012
- Author(s)
  Toshiya Hirayama and Masayuki Nakano
- Organizer
  The 6th Nagasaki Symposium on Tropical and Emerging Infectious Diseases & The 11th Nagasaki-Singapore Medical Symposium
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Low-density lipoprotein receptor-related protein-1 (LRP-l) mediates autophagy and apoptosis caused by Helicobacter pylori VacA2012
- Author(s)
  Kinnosuke Yahiro, Masayuki Nakano, Masatoshi Noda, Jan Sap, Joel Moss, Toshiya Hirayama
- Organizer
  EMBO 2012 meeting
- Place of Presentation
  Nice
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Helicobacter pylori vacuolating toxin, VacA, and its receptors2012
- Author(s)
  Toshiya Hirayama
- Organizer
  Helicobacter pylori infection and gastric cancer prevention
- Place of Presentation
  Shinryoku Hall, Kobe, Japan
- Year and Date
  2012-02-24
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Evalution of the Function of Stn produced by salmonella2012
- Author(s)
  Masayuki Nakano,Eiki Yamasaki,Takaaki Shimamoto, Akira Takahashi, Hisao Kurazono, Toshiya Hirayama
- Organizer
  The 11th Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路市
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Pleiotropic action of VacA toxin of Helicobacter pylori2012
- Author(s)
  Toshiya Hirayama
- Organizer
  2nd INTERNATIONAL SYMPOSIUM INFECTION-ASSOCIATED CANCERS
- Place of Presentation
  Sapporo, Japan.
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Evalution of the Function of Stn produced by salmonella.2012
- Author(s)
  Masayuki Nakano,Eiki Yamasaki,Takaaki Shimamoto,Akira Takahashi,Hisao Kurazono,Toshiya Hirayama
- Organizer
  The 11th Awaji International Forum on Infection and Immunity
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Low-density lipoprotein receptor-related protein-1 (LRP-1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA.2012
- Author(s)
  Kinnosuke Yahiro, Masayuki Nakano, Masatoshi Noda, Jan Sap, Joel Moss, Toshiya Hirayama
- Organizer
  EMBO 2012 meeting
- Place of Presentation
  Nice, France.
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] ER STRESS CONTRIBUTES TO VAC A INDUCED GASTRIC EPITHERIAL CELL DEATH2012
- Author(s)
  Akazawa Y, H. Isomoto, K. Matsushima, K. Shiozawa, N. Yamaguchi, K. Ohnita, F. Takeshima, T. Hirayama, K. Nakao
- Organizer
  UEGW 2012
- Place of Presentation
  Amsterdam, Netherland.
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Low-density lipoprotein receptor-related protein-1 (LRP-1)mediates autophagy and apoptosis caused by Helicobacter pylori VacA..2012
- Author(s)
  Toshiya Hirayama and Masayuki Nakano
- Organizer
  The 6th Nagasaki Symposium on Tropical and Emerging Infectious Diseases & The 11th Nagasaki-Singapore Medical Symposium.
- Place of Presentation
  Nagasaki, Japan.
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] ヘリコバクター・ピロリ感染症と毒素病態学的研究アプローチ2012
- Author(s)
  平山壽哉
- Organizer
  第86回日本感染症学会総会
- Place of Presentation
  長崎市
- Year and Date
  2012-04-26
- Data Source
  KAKENHI-PROJECT-24659199
[Presentation] Mechanisms of H. pylori vacuolating cytotoxin-induced apoptosis in gastric epithelial cells2011
- Author(s)
  Hajime Isomoto, Kazuhiko Nakao,Kayoko Matsushima, Yuko Akazawa, Ayako Matsumoto,Toshiya Hirayama
- Organizer
  The 8th Japan-Korea Joint Symposium on Helicobacter Infection
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Clinical significance of microRNAs in H.pylori-associated gastritis.2011
- Author(s)
  Kayoko Matsushima, Hajime Isomoto, Shigeru Kohno ,Yuko Akazawa ,Naoyuki Yamaguchi, Ken Ohnita, Tatsuki Ichikawa ,Fuminao Takeshima, Kazuhiko Nakano, Toshiya Hirayama
- Organizer
  The 8th Japan-Korea Joint Symposium on Helicobacter Infection
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Enhanced expression of CCL20 and CXCL13 in Helicobacter pylori-associated gastritis in humans2010
- Author(s)
  Hajime Isomoto, Nakashima Y, Nakao K., Hirayama T
- Organizer
  XXIII International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  Rottterdam, The Netherland
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Toshiya Hirayama2010
- Author(s)
  Toshiya Hirayama
- Organizer
  The 10thJapan-Korea International Symposium on Microbiology
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Helicobacter pylori CagA Inhibits Endocytosis of Cytotoxin VacA in Host Cells2010
- Author(s)
  Junko K. Akada, Hiroki Aoki, Toshiya Hirayama, Teruko Nakazawa, Rinji Akada, Kazuyuki Nakamura
- Organizer
  The American Society for Cell Biology 50th Annual Meeting
- Place of Presentation
  Austin, USA
- Data Source
  KAKENHI-PROJECT-22390084
[Presentation] Helicobacter pylori VacA induces GSK3 inhibition through the PI3K/Akt signaling pathway2009
- Author(s)
  Hirayama T, et al.
- Organizer
  XXII International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  ポルト,ポルトガル
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PUBLICLY-21022039
[Presentation] Pleiotropic action of VacA toxin of Helicobacter pylori: VacA induces GSK3 inhibition trough the PI3K/Akt signaling pathway.2009
- Author(s)
  Toshiya Hirayama
- Organizer
  Internationa Sympojium on TGF-βSignaling, Inflammation and Cancer Prevention.
- Place of Presentation
  Incheon, Korea
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA induces GSK3 inhibition through the PI3K/Akt signaling pathway.2009
- Author(s)
  Toshiya Hirayama, Masaaki Nakayama, Hajime Isomoto, Masanori Hatakeyama, Takeshi Azuma, Yoshio Yamaoka, Joel Moss
- Organizer
  XXII International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  Porto, Portugal
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.2009
- Author(s)
  Toshiya Hirayama, Masaaki Nakayama, Hajime Isomoto, Junzo Hisatsune, Shigeru Kohno, Eiki Yamasaki, Hisao Kurazono, Joel Moss
- Organizer
  109th General Meeting of American Society for Microbiology
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA induces GSK3 inhibition through the PI3K/Akt signaling pathway2009
- Author(s)
  Hirayama T, et al.
- Organizer
  XXII International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
- Place of Presentation
  ポルト, ポルトガル
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA increases IL-8 production by p38 MAPK activation via intracellular Ca^<2+>release, leading to ATF-2, CREB and NF-kB activation2008
- Author(s)
  Hirayama T, et al.
- Organizer
  12th International Congress of Bacteriology and Applied Microbiology
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA increases IL-8 production by p38 MAPK activation via intracellular Ca 2+-release, leading to ATF-2, CREB and NF-kB activation2008
- Author(s)
  Toshiya Hirayama, Junzo Hisatsune, Hisao Kurazono, Hajime Isomoto, Joel Moss
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Molecular Characterization of Helicobacter pylori VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38 MAPK in ATF-2, CREB Protein, and NF-kB Activation.2008
- Author(s)
  Hajime Isomoto, Toshiya Hirayama
- Organizer
  The 9th Korea-Japan International Symposium on Microbiology
- Place of Presentation
  Soul, Korea
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] HELICOBACTER PYROLI VACA ENHANCES PGE2 PRODUCTION THROUGH INDUCTION OF COX-2 EXPRESSION VIA p38 MAP KINASE/ATF-2 CASCADE IN AZ-521 CELLS.2008
- Author(s)
  Hajime Isomoto, Joel Moss, Toshiya Hirayama
- Organizer
  7th China-Korea-Japan Joint Conference on Helicobacter Infection
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA-induced IL-8 production in U937 cells is mediated by an increase in intracellular Ca2+ Junzou Hisatsune, Masaaki Nakayama, , followed by activation of ATF-2, CREB and NF-kB.2008
- Author(s)
  Toshiya Hirayama, Junzo Hisatsune, Kayo Matsushima, Hajime Isomoto, Shigeru Kohno, Hisao Kurazono, Joel Moss
- Organizer
  108th General Meeting of American Society for Microbiology
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA increases IL-8 production by p38 MAPK activation via intracellular Ca^<2+>-release, leading to ATF-2, CREB and NF-kB activation2008
- Author(s)
  Hirayama T, et.al.
- Organizer
  12th International Congress of Bacteriology and Applied Micro biology
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-19041060
[Presentation] Vacuolating Cytotoxin of Helicobacter pylori Enhances PGE2 Production Through Induction of COX-2 Expression via a p38 MAP Kinase/ATF-2 Cascade in AZ-521 Cells.2007
- Author(s)
  Toshiya Hirayam
- Organizer
  107th General Meeting of American Society for Microbiology
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA induces COX-2 expression via p38 MAP Kinase/ATF-2 cascade.2007
- Author(s)
  Toshiya Hirayama
- Organizer
  14th International Workshop on Campylobacter, Helicobacter and Related Organisms
- Place of Presentation
  Rotterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-19209014
[Presentation] Helicobacter pylori VacA Enhances PGE2 Production Trough Induction of COX-2 Expression via p38 MAP Kinase/ATF-2 Cascade in AZ-521 Cells.2007
- Author(s)
  Toshiya Hirayama
- Organizer
  42nd Annual Joint Meeting of Cholera and Other Bacterial Enteric Infections
- Place of Presentation
  Austin, USA
- Data Source
  KAKENHI-PROJECT-19209014

1. WADA Akihiro (70253698)

# of Collaborated Projects : 9results

# of Collaborated Products : 3results
2. KURAZONO Hisao (90186487)

# of Collaborated Projects : 5results

# of Collaborated Products : 0results
3. ISOMOTO Hajime (90322304)

# of Collaborated Projects : 4results

# of Collaborated Products : 22results
4. TAKEDA Yoshifumi (30029772)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
5. MAKINO Souichi (30181621)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
6. 大西洋平 (00313023)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. AOYAMA Nobuo (30243299)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. YAHIRO Kinnosuke (80345024)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. AKADA Junko (30346548)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. NISHIKAWA Jun (00379950)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. OKUDA Masumi (40531091)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. NAKAMURA Kazuyuki (90107748)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. NAKAMURA Mikiko (20457310)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. NAKANO Masayuki (60398005)

# of Collaborated Projects : 1results

# of Collaborated Products : 23results
15. YAMASAKI Shinji (70221653)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. KOSAKA Mitsuo (30079983)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. NAGATAKE Tsuyoshi (30164445)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. NAKAMURA Michio (30091276)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. KANBARA Hiroji (20029789)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. OHWATARI Nobu (80128165)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. NODA Masatoshi (60164703)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. MASHIMA Hirosato (10261869)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. HOSHI Hidenobu (30301188)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. YUTSUDO Takashi (80182674)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. 山崎栄樹 (40514708)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. 山本達男 (80095843)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. 土屋勝彦 (90073006)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
28. 木村美幸 (60346418)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
29. 保田立二 (30092357)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
30. 冨田敏夫 (00126129)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
31. 松田二美 (40114649)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
32. MOSS Joel

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
33. SHIRASAKA Daisuke

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
34. 井上克枝

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
35. 佐藤金夫

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
36. 尾崎由基男

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
37. 高野勝弘

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

HIRAYAMA Toshiya 平山 壽哉

Research Projects

Research Products

Co-Researchers

Anti-Helicobacter pylori antibody succession during gastric carcinogenesis monitored with proteomics and antigen-chip analysis

Principal Investigator

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Analysis of gene expression of Helicobacter pylori VacAPrincipal Investigator

Principal Investigator

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Analysis on multifunctional receptors for Helicobacter pylori VacAPrincipal Investigator

Principal Investigator

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ヘリコバクター・ピロリVacA毒素の毒性発現機序Principal Investigator

Principal Investigator

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Review Section

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ヘリコバクター・ピロリVacA毒素の毒性発現機序Principal Investigator

Principal Investigator

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Review Section

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Toxicity of Helicobacter pylori VacA and its mutual effect with CagAPrincipal Investigator

Principal Investigator

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Comparison of virulence factors produced by Helicobacter pylori between Philippine and ThailandPrincipal Investigator

Principal Investigator

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Study on the function of receptor for Helicobacter pylori VacA and the mechanism of its intoxicationPrincipal Investigator

Principal Investigator

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Mechanism of Helicobacter pylonVacAintoxicationPrincipal Investigator

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Surveillance of Bacterial Intestinal diseases in Southeast Asian countries

Principal Investigator

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ピロリ菌空胞化毒素を阻害する血清成分に関する研究Principal Investigator

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ヘリコバクター・ピロリVacA毒素の空胞致死活性機序Principal Investigator

Principal Investigator

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Review Section

Research Institution

Research for comparison of VacA in H. pylori infectious diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

HIRAYAMA Toshiya 平山壽哉