Takayama Kozo 高山幸三

… Alternative Names

TAKAYAMA Kozo 高山幸三

TAKAYAMA K. 高山幸三

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Researcher Number	00130758
Other IDs
Affiliation (Current)	2025: 城西大学, 薬学部, 招聘教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 城西大学, 薬学部, 招聘教授 2004 – 2016: 星薬科大学, 薬学部, 教授 2000 – 2002: 星薬科大学, 薬学部, 教授 1993 – 1997: 星薬科大学, 薬学部, 助教授 1992: 星薬科大学, 薬学部, 講師 1987 – 1990: 星薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy Except Principal Investigator Physical pharmacy / Physical pharmacy / 医薬分子機能学
Keywords	Principal Investigator 吸収促進剤 / 経皮吸収 / 崩壊時間 / 自己組織化マップ / 最適化 / 皮膚刺激 / フラクタル解析 / Response surface method / Optimization / 応答曲面法 … More / 人工ニューラルネットワーク / 引張強度 / 重要品質特性 / 錠剤 / 残留応力 / DPCモデル / 有限要素法 / CAEシミュレーション / 硬度 / 破壊強度 / 製剤設計 / ヘアレスラット / d-リモネン / フラクタル次元 / 密度分布 / コンピュータ－シミュレーション / 弾塑性体 / 部分最小二乗法 / X線CT / 錠剤形状 / 深層学習 / エラスティックネット / スパースモデリング / シミュレーション / Drug delivery system / Clustering / Self-organizing map / Bootstrap re-sampling / Robustness / Thin-plate spline interpolation / 経皮経粘膜吸収 / 多目的同時最適化 / 薬物送達システム / クラスタリング / ブートストラップ法 / 信頼性評価 / 薄板スプライン補間 / Ketoprofen / Drug delivery / Chemical enhancer / Transdermal absorption / Formulation / Artificial neural network / 刺激性 / 構造活性相関 / メントール誘導体 / ケトプロフェン / 薬物送達 / 経粘膜吸収 / 放出制御 / 製剤処方 / absorption promoter / hairless rat / skin damage / stratum corneum / percutaneous absorption / confocal laser microscope / solid fractal dimension / fractal analysis / 角質細胞 / 共焦点レーザー顕微鏡 / 立体フラクタル次元 / 粉体 / R錠 / 割線深度 / 分割均一性 / 分割強度 / 弾性連続体 / 割線錠 / 拡張シンプレックス / 溶出時間 / 溶出率 / 製剤特性 / サポートベクターマシン / 比表面積 / 品質特性 / 主薬物性 / ニューラルネットワーク / 錠剤データベース / 感度分析 / コントロールスペース / デザインスペース / モンテカルロ探索 / 信頼区間 / 薄版スプライン / ヒストグラム / 実験計画法 / 薄板スプライン / 潜在構造分析 / 長期徐放システム / ジルチアゼム塩酸塩 / 共分散構造分析 / ベイジアンb\ネットワーク / インシリコ予測 / ブートストラップ / スプライン / 血管像 / 鶏胚 / フラクタル図形 / コレステロール / 膜流動性 / ゲル液晶転移 / 脂質二分子膜 / リポソーム / テルペン類 … More Except Principal Investigator 経皮吸収促進剤 / 皮膚刺激 / インスリン / high throughput screening / Skin irritation / Ketoprofen / Menthol / Absorption promoter / ラット / ケトプロフェン / メントール / O-エチルメントール / 経鼻吸収 / バイオアベイラビリティ / 細胞膜透過ペプチド / バイオ医薬 / 薬物送達システム / Permeability / Sodium Glycocholate / Powder Dosage Form / Liposome / Insulin / Interferon / Mucosa absorption / Nasal absorption / 粘膜付着 / 表面電荷 / リポソーム / インターフェロン / グリココ-ル酸ナトリウム / リン脂質 / 膜透過係数 / グルココ-ル酸ナトリウム / 鼻粘膜 / リポソ-ム / 粘膜吸収 / MTT assay / skin irritation / quartz crystal microbalance / penetration enhancement / alternative skin / Skin permeation / three-dimensional cultured human skin model / skin metabolism / skin permeation / High Throughput Screening / 三次元培養ヒト皮膚モデル / MTT試験 / 水晶発振子 / 透過促進 / 代替皮膚 / High Throghput Screening / 皮膚透過 / 三次元培養皮膚モデル / Chemical shift / log P value / Rat / Thiomenthol / log P値 / 化学シフト / logP値 / チオメントール / Stratum corneum / Pharmacological activity / omicron-Ethylmenthol / Percutaneous absorption / イソニアジド / フルルビプロフェン / エチルエーテル誘導体 / 促進機構 / ケトプロ / 経皮吸 / 角質細胞 / 薬理活性 / 吸収促進剤 / 経皮吸収 / ポリビニルピロリドン / カルボキシビニルポリマー / ヒドロキシプロピルセルロース / 粘膜付着性 / 放出制御 / 薬物放出 / 高分子集合体 / 経口投与 / バイオアベリラビリティ / 経口吸収 / バイオ薬物 / ペネトラチン / 吸収促進 / 非侵襲的投与経路 / ドラッグデリバリー / Caco-2細胞 / 吸収改善 / 機能性ペプチド Less

Combined use of deep learning and CAE simulation for design and optimization of pharmaceutical productsPrincipal Investigator
- Principal Investigator
  
  Takayama Kozo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University
Establishment of in silico pharmaceutical product design based on CAE simulationPrincipal Investigator
- Principal Investigator
  
  Takayama Kozo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Creaton of tablet database and visulalization of its internal structurePrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Kozo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Development of non-invasive delivery of biopharmaceuticals equipped with novel membrane permeation technology and their translational research
- Principal Investigator
  
  TAKEDA Mariko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kobe Gakuin University
  Hoshi University
Development research of next generation type of non-invasive DDS using delivery carrier
- Principal Investigator
  
  MORISHITA Mariko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Development of in silico prediction technique for pharmaceutical design and optimizationPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Kozo
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Optimization of transdermal and transmucosal drug delivery systems utilizing thin-plate spline interpolationPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Kozo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Optimization of transdermal and transmucosal drug delivery systems utilizing artificial neural networksPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Kozo
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Utility of the three-dimensional cultured human skin model as a tool to evaluate rapid determination of skin permeation of drag and skin irritation.
- Principal Investigator
  
  SUGIBAYASHI Kenji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Josai University
Promoting activity of menthol derivatives containing sulfur atom on the percutaneous absorption of drugs
- Principal Investigator
  
  NAGAI Tsuneji
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Evaluation of percutaneous absorption promoters by means of solid fractal analysis of skin stratum corneumPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Kozo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
鶏胚血管像のフラクタル解析による経皮吸収促進剤の刺激性の評価Principal Investigator
- Principal Investigator
  
  高山幸三
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Development of novel percutaneous absorption promoters
- Principal Investigator
  
  NAGAI Tsuneji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
皮膚表面のフラクタル解析による経皮吸収促進剤の評価Principal Investigator
- Principal Investigator
  
  高山幸三
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
脂質二分子膜による経皮吸収促進剤の作用機構の解析Principal Investigator
- Principal Investigator
  
  高山幸三
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
Studies on Dosage Forms for Intranasal Administration of Drugs
- Principal Investigator
  
  NAGAI T.
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hoshi University
高分子集合体の機能と利用した薬物放出の制御に関する研究
- Principal Investigator
  
  NAGAI Tsuneji
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hoshi University

[Book] 医療・医学・薬学におけるSOMの応用第18章固形製剤の開発2015
- Author(s)
  大貫義則，高山幸三
- Publisher
  海文堂
- Data Source
  KAKENHI-PROJECT-26460047
[Book] 薬剤学概史製剤開発への計量化学的手法の導入2015
- Author(s)
  高山幸三
- Publisher
  日本薬剤学会
- Data Source
  KAKENHI-PROJECT-26460047
[Book] ドラッグデリバリーシステム第2章量的制御,高分子学会(編)2012
- Author(s)
  高山幸三
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-23590053
[Book] ドラッグデリバリーシステム第2章量的制御2012
- Author(s)
  高山　幸三
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-23590053
[Book] The Drug Delivery System-薬学が語るDDSの世界-,米谷芳枝(編),第3章放出制御の基礎と実際2012
- Author(s)
  高山幸三
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-23590053
[Book] 造粒・打錠プロセスにおける適正操作とトラブル対策ノウハウ集第7章実験計画法による製剤の処方設計・最適化2010
- Author(s)
  宮嶋勝春、高山幸三
- Total Pages
  347
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-19590045
[Book] 最新・経皮吸収～開発の基礎から申請のポイントまで～(第2章経皮吸収型製剤の製剤設計)2008
- Author(s)
  小幡誉子, 高山幸三
- Publisher
  情報機構
- Data Source
  KAKENHI-PROJECT-19590045
[Book] 最新・経皮吸収～開発の基礎から申請のポイントまで～第2章経皮吸収型製剤の製剤設計2008
- Author(s)
  小幡誉子、高山幸三
- Total Pages
  296
- Publisher
  情報機構
- Data Source
  KAKENHI-PROJECT-19590045
[Book] 基礎から学ぶ製剤化のサイエンス第1章物質の溶解2008
- Author(s)
  高山幸三
- Total Pages
  335
- Publisher
  エルゼビア・ジャパン
- Data Source
  KAKENHI-PROJECT-19590045
[Book] 基礎から学ぶ製剤化のサイエンス(第1章物質の溶解)2008
- Author(s)
  高山幸三
- Publisher
  エルゼビア・ジャパン
- Data Source
  KAKENHI-PROJECT-19590045
[Book] DDSの基礎と開発、第2章ドラッグデリバリーシステムの方法論、放出制御2006
- Author(s)
  高山幸三
- Total Pages
  9
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-16590035
[Book] DDSの基礎と開発,第2章ドラッグデリバリーシステムの方法論,放出制御2006
- Author(s)
  高山幸三
- Total Pages
  9
- Publisher
  シーエムシー出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Book] DDS研究の現状と将来展望,第8章ナノテクノロジー製剤技術とDDS-最適設計支援システムによるDDS開発-2005
- Author(s)
  高山幸三
- Total Pages
  3
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-16590035
[Book] ドラッグデリバリーシステムの新展開(究極の薬物治療を目指して)第6章9.2 非線形応答曲面法によるDDSの設計と最適化2004
- Author(s)
  高山幸三
- Total Pages
  9
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Chitosan complexed carboxymethylated iota-carrageenan oral insulin particles: Stability, permeability and in vivo evaluation2019
- Author(s)
  P. Sahoo, K.H. Leong, S. Nyamathulla, Y. Onuki, K. Takayama
- Journal Title
  
  Materials Today Commun.
  
  Volume: 20 Pages: 100557-100557
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08252
[Journal Article] Prediction of tablet characteristics based on sparse modeling for residual stresses simulated by the finite element method incorporating Drucker-Prager cap model2019
- Author(s)
  K. Takayama, T. Sato, K. Sato, H. Todo, Y. Obata, K. Sugibayashi
- Journal Title
  
  J. Drug. Del. Sci. Tech.
  
  Volume: 52 Pages: 1021-1031
- DOI
  10.1016/j.jddst.2019.06.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08252
[Journal Article] Time-temperature superposition principle for the kinetic analysis of destabilization of pharmaceutical emulsions2019
- Author(s)
  T. Tsuji, K. Mochizuki, K. Okada, Y. Hayashi, K. Takayama, Y. Onuki
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 563 Pages: 446-452
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08252
[Journal Article] Modeling of quantitative relationships between physicochemical properties of active pharmaceutical ingredients and tensile strength of tablets using a large dataset and a boosted tree2018
- Author(s)
  Hayashi, Y., Oishi, T., Shirotori, K., Marumo, Y., Kosugi, A., Kumada, S., Hirai, D., Takayama, K., Onuki, Y.
- Journal Title
  
  Drug Dev. Ind. Pharm.
  
  Volume: in press Issue: 7 Pages: 1090-1098
- DOI
  10.1080/03639045.2018.1434195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08192, KAKENHI-PROJECT-17K08252
[Journal Article] Optimization of Premix Powders for Tableting Use2018
- Author(s)
  H. Todo, K. Sato, K. Takayama, K. Sugibayashi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 7 Pages: 748-756
- DOI
  10.1248/cpb.c18-00213
- NAID
  130007386754
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2018-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08252
[Journal Article] Combination Strategy with Complexation Hydrogels and Cell-Penetrating Peptides for Oral Delivery of Insulin2018
- Author(s)
  Y. Fukuoka, E. S. Khafagy, T. Goto, N. Kamei, K. Takayama, N. A. Peppas, M. Takeda-Morishita
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 5 Pages: 811-814
- DOI
  10.1248/bpb.b17-00951
- NAID
  130006730708
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-05-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08252, KAKENHI-PROJECT-16K08211
[Journal Article] Enhancement of galantamine HBr skin permeation using sonophoresis and limonene-containing PEGylated liposomes2018
- Author(s)
  R. Rangsimawong, Y. Obata, P. Opanasopit, T. Ngawhirunpat, K. Takayama
- Journal Title
  
  AAPS PharmSciTech.
  
  Volume: 19 Issue: 3 Pages: 1093-1104
- DOI
  10.1208/s12249-017-0921-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08252
[Journal Article] Strength Simulation of Scored Tablets Based on the Finite Element Method Using an Extreme Vertices Design2018
- Author(s)
  Y. Hayashi, N. Okada K. Takayama, Y. Obata, Y. Onuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 7 Pages: 727-731
- DOI
  10.1248/cpb.c18-00069
- NAID
  130007386741
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2018-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08252, KAKENHI-PROJECT-16K08192
[Journal Article] Prediction of Skin Permeation of Flurbiprofen from Neat Ester Oils and Their <i>O</i>/<i>W</i> Emulsions2018
- Author(s)
  H. Todo, M. Tamura, T. Uchida, M. Kurumada, A. Motoki, T. Sano, Y. Onuki, K. Takayama, K. Sugibayashi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 10 Pages: 959-966
- DOI
  10.1248/cpb.c18-00384
- NAID
  130007492373
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2018-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08252
[Journal Article] Nondestructive monitoring of the dispersion state of titanium dioxide nanoparticles in concentrated suspensions using magnetic resonance imaging2018
- Author(s)
  T. Ito, C. Kida, K. Okada, J. Ikeda, K. Otomura, Y. Hayashi, Y. Obata, K. Takayama, Y. Onuki
- Journal Title
  
  Langmuir
  
  Volume: 34 Pages: 12093-12099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08252
[Journal Article] Prediction of Dissolution Data Integrated in Tablet Database Using Four-Layered Artificial Neural Networks2017
- Author(s)
  K.Takayama, S. Kawai, Y.Obata, H. Todo, K. Sugibayashi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 65 Issue: 10 Pages: 967-972
- DOI
  10.1248/cpb.c17-00539
- NAID
  130006109933
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08252
[Journal Article] Relationships between response surfaces for tablet characteristics of placebo and API-containing tablets2017
- Author(s)
  Hayashi, Y., Tsuji, T., Shirotori, K., Oishi, T., Kosugi, A., Kumada, S., Hirai, D., Takayama, K., Onuki, Y.
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 532 Issue: 1 Pages: 82-89
- DOI
  10.1016/j.ijpharm.2017.08.111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08192, KAKENHI-PROJECT-17K08252
[Journal Article] Latent structure analysis in the pharmaceutical process of tablets prepared by wet granulation2016
- Author(s)
  N. Uehara, Y. Hayashi, H. Mochida, S. Otoguro, Y. Onuki, Y. Obata, K. Takayama
- Journal Title
  
  Drug Dev. Ind. Pharm.
  
  Volume: 42 Issue: 1 Pages: 116-122
- DOI
  10.3109/03639045.2015.1035281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460047
[Journal Article] Prediction of color changes in acetaminophen solution using the time-temperature superposition principle2016
- Author(s)
  K. Mochizuki, K. Takayama
- Journal Title
  
  Drug Dev. Ind. Pharm.
  
  Volume: 42 Issue: 7 Pages: 1050-1057
- DOI
  10.3109/03639045.2015.1107091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460047
[Journal Article] Mechanical stress simulation of scored tablets based on the finite element method and experimental verification2016
- Author(s)
  N. Okada, Y. Hayashi, Y. Onuki, T. Miura, Y. Obata, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 64 Pages: 1142-1148
- NAID
  130005253906
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460047
[Journal Article] Numerical investigation of the residual stress distribution of flat-faced and convexly curved tablets using the finite element method2015
- Author(s)
  S. Otoguro, Y. Hayashi, T. Miura, N. Uehara, S. Utsumi, Y. Onuki, Y. Obata, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 63 Pages: 890-900
- NAID
  130005105731
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460047
[Journal Article] Self-organizing map analysis for understanding comprehensive relationships between formulation variables, state of water, and the physical stability of pharmaceutical emulsions2015
- Author(s)
  Y. Onuki, N. Hasegawa, A. Horita, N. Ueno, C. Kida, Y. Hayashi, Y. Obata, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 63 Pages: 901-906
- NAID
  130005105720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460047
[Journal Article] Effect of process variables on the Drucker-Prager Cap model and residual stress distribution of tablets estimated by the finite element method2014
- Author(s)
  Y. Hayashi, S. Otoguro, T. Miura, Y. Onuki, Y. Obata, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 62 Pages: 1062-1072
- NAID
  130004677397
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460047
[Journal Article] Latent structure modeling underlying theophylline tablet formulations using a Bayesian network based on a self-organizing map clustering2014
- Author(s)
  A. Yasuda, Y. Onuki, Y. Obata, K. Takayama
- Journal Title
  
  Drug Dev. Ind. Pharm
  
  Volume: July 4 Issue: 7 Pages: 1-8
- DOI
  10.3109/03639045.2014.935391
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460047
[Journal Article] Bootstrap resampling technique to evaluate the reliability of the optimal liposome formulation: Skin permeability and stability response variables2014
- Author(s)
  S. Duangjit, P. Opanasapit, T. Rojanarata, J. Takayama, K. Takayama, T. Ngawhirunpat
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 37 Pages: 1543-1549
- NAID
  130004057439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460047
[Journal Article] Self-organizing map analysis using multivariate data from theophylline tablets predicted by a thin-plate spline interpolation2013
- Author(s)
  A. Yasuda, Y. Onuki, Y. Obata, R. Yamamoto, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 61 Pages: 304-309
- NAID
  130003360736
- URL
  https://www.jstage.jst.go.jp/article/cpb/61/3/61_c12-00895/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Prediction of tablet characteristics from residual stress distribution estimated by the finite element method2013
- Author(s)
  Y. Hayashi, T. Miura, T. Shimada, Y. Onuki, Y. Obata, K. Takayama
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 102 Issue: 10 Pages: 2678-2686
- DOI
  10.1002/jps.23675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053, KAKENHI-PROJECT-25460045
[Journal Article] A novel approach to establishing the design space for the oral formulation manufacturing process2013
- Author(s)
  T. Norioka, Y. Hayashi, Y. Onuki, H. Andou, D. Tsunashima, K. Yamashita, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 61 Pages: 39-49
- NAID
  130003360719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Determination of the optimal cell-penetrating peptide sequence for intestinal insulin delivery based on molecular orbital analysis with self-organization maps2013
- Author(s)
  Kamei N, Kikuchi S, Takeda-Morishita M, Terasawa Y, Yasuda A, Yamamoto S, Ida N, Nishio R, Takayama K
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 102 Issue: 2 Pages: 469-479
- DOI
  10.1002/jps.23364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590056
[Journal Article] Determination of the Optimal Cell-Penetrating Peptide Sequence for Intestinal Insulin Delivery Based on Molecular Orbital Analysis with Self-Organizing Maps2013
- Author(s)
  N. Kamei, S. Kikuchi, M. Takeda-Morishita, Y. Terasawa, Yasuda, S. Yamamoto, N. Ida, R. Nishio, K. Takayama
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 102 Pages: 469-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590056
[Journal Article] Mechanistic study of the uptake/permeation of cell-penetrating peptides across a Caco-2 monolayer and their stimulatory effect on epithelial insulin transport2013
- Author(s)
  Kamei N, Onuki Y, Takayama K, Takeda-Morishita M
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 102 Issue: 11 Pages: 3998-4008
- DOI
  10.1002/jps.23708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590056
[Journal Article] A novel approach to establishing the design space for the oral formulation manufacturing process2013
- Author(s)
  T. Norioka, Y. Hayashi, Y. Onuki, H. Andou, D. Tsunashima, K. Yamashita, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 61 Pages: 39-49
- NAID
  130003360719
- URL
  https://www.jstage.jst.go.jp/article/cpb/61/1/61_c12-00743/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Self-organizing map analysis using multivariate data from theophylline tablets predicted by a thin-plate spline interpolation2013
- Author(s)
  A. Yasuda, Y. Onuki, Y. Obata, R. Yamamoto, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 61 Pages: 304-309
- NAID
  130003360736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Effects of packaging and heat transfer kinetics on drug-product stability during storage under uncontrolled temperature conditions2013
- Author(s)
  T. Nakamura, T. Yamaji, K. Takayama
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 102 Issue: 5 Pages: 1495-1503
- DOI
  10.1002/jps.23486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Mechanistic study on the uptake/permeation of cell-penetrating peptides across Caco-2 monolayer and their stimulatory effect on epithelial insulin transport2013
- Author(s)
  N. Kamei, Y. Onuki, K. Takayama, M. Takeda-Morishita
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3998-4008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590056
[Journal Article] Latent structure analysis of the process variables and pharmaceutical responses of an orally disintegrating tablet2012
- Author(s)
  Y. Hayashi, E. Oshima, J. Maeda, Y. Onuki, Y. Obata, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 60 Pages: 1419-1425
- NAID
  130001852385
- URL
  https://www.jstage.jst.go.jp/article/cpb/60/11/60_c12-00522/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Novel method for constructing a large-scale desing space in lubrication process by using Bayesian estimation based on the reliability of a scale-up rule2012
- Author(s)
  J. Maeda, T. Suzuki, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 60 Pages: 1155-1163
- URL
  https://www.jstage.jst.go.jp/article/cpb/60/9/60_c12-00340/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Menthosomes, novel ultradeformable vesicles for transdermal drug delivery : Optimization and characterization2012
- Author(s)
  S. Duangjit, Y. Obata, H. Sano, S. Kikuchi, Y. Onuki, P. Opanasopit, T. Ngawhirunpat, Y. Maitani, K. Takayama
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 35 Pages: 1720-1728
- NAID
  130001872364
- URL
  https://www.jstage.jst.go.jp/article/bpb/35/10/35_b12-00343/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Novel method to construct large-scale design space in lublication process ultilizing Bayesian estimation based on a small-scale design-of-experiment and small sets of large-scale manufacturing data2012
- Author(s)
  J. Maeda, T. Suzuki, K. Takayama
- Journal Title
  
  Drug Dev. Ind. Pharm.
  
  Volume: 38 Issue: 12 Pages: 1451-1459
- DOI
  10.3109/03639045.2011.653790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Reliability evaluation of nonlinear design space in pharmaceutical product development2012
- Author(s)
  Y. Hayashi, S. Kikuchi,Y. Onuki, K. Takayama
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 101 Issue: 1 Pages: 333-341
- DOI
  10.1002/jps.22734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Relationship between diffusivity of water molecules inside hydrating tablets and their drug release behavior elucidated by magnetic resonance imaging2012
- Author(s)
  S. Kikuchi, Y. Onuki, H. Kuribayashi, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 60 Pages: 536-542
- NAID
  130001852446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Latent structure analysis of the process variables and pharmaceutical responses of an orally disintegrating tablet2012
- Author(s)
  Y. Hayashi, E. Oshima, J. Maeda, Y. Onuki, Y. Obata, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 60 Pages: 1419-1425
- NAID
  130001852385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Contribution of the physicochemical properties of active pharmaceutical ingredients to tablet properties identified by ensemble artificial neural networks and Kohonen's self-organizing maps2012
- Author(s)
  Y. Onuki, S. Kawai, H. Arai, J. Maeda, K. Takagaki, K. Takayama
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 101 Pages: 2372-2381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Relationship between diffusivity of water molecules inside hydrating tablets and their drug release behavior elucidated by magnetic resonance imaging2012
- Author(s)
  S. Kikuchi, Y. Onuki, H. Kuribayashi, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 60 Pages: 536-542
- NAID
  130001852446
- URL
  https://www.jstage.jst.go.jp/article/cpb/60/4/60_4_536/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] A 5% glucose infusion fluid provokes significant precipitation of phenytoin sodium injection via interruption of the cosolvent effect of propylene glycol2012
- Author(s)
  Y. Onuki, M. Ikegami-Kawai, K. Ishitsuka, Y. Hayashi, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 60 Pages: 86-93
- NAID
  130001852352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] A 5% glucose infusion fluid provokes significant precipitation of phenytoin sodium injection via interruption of the cosolvent effect of propylene glycol2012
- Author(s)
  Y. Onuki, M. Ikegami-Kawai, K. Ishitsuka, Y. Hayashi, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 60 Pages: 86-93
- NAID
  130001852352
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22223379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Novel method for constructing a large-scale desing space in lubrication process by using Bayesian estimation based on the reliability of a scale-up rule2012
- Author(s)
  J. Maeda, T. Suzuki, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 60 Pages: 1155-1163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Contribution of the physicochemical properties of active pharmaceutical ingredients to tablet properties identified by ensemble artificial neural networks and Kohonen’s self-organizing maps2012
- Author(s)
  Y. Onuki, S. Kawai, H. Arai, J. Maeda, K. Takagaki, K. Takayama
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 101 Issue: 7 Pages: 2372-2381
- DOI
  10.1002/jps.23134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Optimization of the manufacturing process for oral formulations using multivariate statistical methods2011
- Author(s)
  T. Norioka, S. Kikuchi, Y. Onuki, K. Takayama, K. Imai
- Journal Title
  
  J. Pharm. Inov
  
  Volume: 6 Issue: 3 Pages: 157-169
- DOI
  10.1007/s12247-011-9111-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Reliability evaluation of the desing space of the granulation process of mefenamic acid tablets using a bootstrap resampling technique2011
- Author(s)
  H. Arai, T. Suzuki, S. Yada, C. Kaseda, Y. Onuki, K. Takayama
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 59 Pages: 608-617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Reliability evalua- tion of the desing space of the granulation process of mefenamic acid tablets using a bootstrap resampling technique2011
- Author(s)
  Arai, T. Suzuki, S. Yada, C. Kaseda, Y. Onuki, K. Takayama
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 59 Pages: 608-617
- URL
  https://www.jstage.jst.go.jp/article/cpb/59/5/59_5_608/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Modeling of latent structure of indomethacin solid dispersion tablet using Bayesian networks2011
- Author(s)
  Y. Hayashi, S. Kikuchi, K. Takayama
- Journal Title
  
  Drug Development and Industrial Pharmacy
  
  Volume: 37 Pages: 1290-1297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Latent structure analysis in pharmaceutical formula- tions using Kohonen's self-organizing map and a Bayesian Network2011
- Author(s)
  S. Kikuchi, Y. Onuki, A. Yasuda, Y. Hayashi, K. Takayama
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 100 Issue: 3 Pages: 964-975
- DOI
  10.1002/jps.22340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Latent structure analysis in pharmaceutical formulations using Kohonen’s self-organizing map and a Bayesian Network2011
- Author(s)
  S. Kikuchi, Y. Onuki, A. Yasuda, Y. Hayashi, K. Takayama
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 100 Pages: 964-975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590053
[Journal Article] Multivariate statistical approach to optimizing sustained-release tablet formulations containing diltiazem hydrochloride as a model highly water-soluble drug2010
- Author(s)
  S.Kikuchi, K.Takayama
- Journal Title
  
  Int.J.Pharm. 386
  
  Pages: 149-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Self-organizing map analysis using multivariate data from theophylline powders predicted by a thin-plate spline interpolation2010
- Author(s)
  A.Yasuda, Y.Onuki, S.Kikuchi, K.Takayama
- Journal Title
  
  J.Pharm.Sci. 99
  
  Pages: 4535-4542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography2010
- Author(s)
  N.Kamei, M.Morishita, Y.Kanayama, K.Hasegawa, M.Nishimura, E.Hayashinaka, Y.Wada, Y.Watanabe, K.Takayama
- Journal Title
  
  J.Control.Release
  
  Volume: 146 Pages: 16-22
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Creation of a tablet database containing several active ingredients and prediction of their pharmaceutical characteristics based on ensemble artificial neural networks2010
- Author(s)
  K.Takagaki, H.Arai, K.Takayama
- Journal Title
  
  J.Pharm.Sci. 99
  
  Pages: 4201-4214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] A statistical approach to the development of a transdermal delivery system for ondansetron2010
- Author(s)
  Y.Obata, Y.Ashitaka, S.Kikuchi, K.Takayama
- Journal Title
  
  Int.J.Pharm. 399
  
  Pages: 87-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides2010
- Author(s)
  E.S.Khafagy, M.Morishita, K.Takayama
- Journal Title
  
  Int.J.Pharm. 388巻
  
  Pages: 209-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Structural requirements of penetratin absorption enhancement efficiency for insulin delivery2010
- Author(s)
  E.S.Khafagy, M.Morishita, K.Takayama
- Journal Title
  
  J.Control.Release
  
  Volume: 143 Pages: 302-310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Role of individual test samples in optimal solutions in pharmaceuticals predicted using a nonlinear response surface method2010
- Author(s)
  Y.Onuki, S.Kikuchi, A.Yasuda, K.Takayama
- Journal Title
  
  Int.J.Pharm. 396
  
  Pages: 75-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Structural requirements of penetratin absorption enhancement efficiency for insulin delivery2010
- Author(s)
  E.S.Khafagy, M.Morishita, K.Takayama
- Journal Title
  
  J.Control.Release 143巻
  
  Pages: 302-310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides2010
- Author(s)
  E.S.Khafagy, M.Morishita, K.Takayama
- Journal Title
  
  Int.J.Pharm.
  
  Volume: 388 Pages: 209-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Phase behavior in a ternary lipid membrane estimated using a nonlinear response surface method and Kohonen's self-organizing map2010
- Author(s)
  Y.Onuki, K.Takayama
- Journal Title
  
  J.Col.Int.Sci. 343
  
  Pages: 628-633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Efficiency of cell-penetrating peptides on the absorption of therapeutic peptides, proteins and hydrophilic macromolecules2009
- Author(s)
  E.S.Khafagy, M.Morishita, K.Takayama
- Journal Title
  
  Int.J.Pharm. 381巻
  
  Pages: 49-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Reliability assessment for the optimal formulations of pharmaceutical products predicted by a nonlinear response surface method2009
- Author(s)
  S.Kikuchi, K.Takayama
- Journal Title
  
  Int.J.Pharm. 374
  
  Pages: 5-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Prediction of permeability of FD-4 through porous poly (2-hydroxyethyl methacrylate) membrane by multiple linear regression and artificial neural network2009
- Author(s)
  F.Yanagawa, Y.Onuki, M.Morishita, K.Takayama
- Journal Title
  
  Pharmazie 64
  
  Pages: 311-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Efficiency of cell-penetrating peptides on the absorption of therapeutic peptides, proteins and hydrophilic macromolecules2009
- Author(s)
  E.S.Khafagy, M.Morishita, K.Takayama
- Journal Title
  
  Int.J.Pharm. 381
  
  Pages: 49-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Reliability assessment for the optimal formulations of pharmaceutical products predicted by a nonlinear response surface method2009
- Author(s)
  S. Kikuchi, K. Takayama
- Journal Title
  
  Int.J.Pharm. 374
  
  Pages: 5-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Effect of an experimental design for evaluating the nonlinear optimal formulation of theophylline tablets using a bootstrap resampling technique2009
- Author(s)
  H.Arai, T.Suzuki, C.Kaseda, K.Takayama
- Journal Title
  
  Chem.Pharm.Bull. 57
  
  Pages: 572-579
- NAID
  130000124342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides,2009
- Author(s)
  N.Kamei, M.Morishita, K.Takayama
- Journal Title
  
  J.Control.Release 136巻
  
  Pages: 179-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Effect of an experimental design for evaluating the nonlinear optimal formulation of theophylline tablets using a bootstrap resampling technique2009
- Author(s)
  H. Arai, T. Suzuki, C. Kaseda, K. Takayama
- Journal Title
  
  Chem.Pharm.Bull. 57
  
  Pages: 572-579
- NAID
  130000124342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides2009
- Author(s)
  N.Kamei, M.Morishita, K.Takayama
- Journal Title
  
  J.Control. Release 136
  
  Pages: 179-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Complexation hydrogels for oral delivery of insulin, interferon βand calcitonin2009
- Author(s)
  N.Kamei, M.Morishita, H.Chiba, N.J.Kaviandan, N.A.Peppas, K.Takayama
- Journal Title
  
  J.Control. Release 134
  
  Pages: 98-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Effect of cell-penetrating peptides on the nasal absorption of insulin2009
- Author(s)
  E.S.Khafagy, M.Morishita, K.Isowa, J.Imai, K.Takayama
- Journal Title
  
  J.Control. Release 133
  
  Pages: 103-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Prediction of survival and complications after percutaneous endoscopic gastrostomy in an individual by using clinical factors with an artificial neural network system2009
- Author(s)
  T.Takayama
- Journal Title
  
  Eur.J.Gastroenterol.Hepatol. 21
  
  Pages: 1279-1285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Development of photo-crosslinked polyacrylic acid hydrogel as an adhesive for dermatologocal patches : Involvement of formulation factors in physical properties and pharmacological effects2008
- Author(s)
  Y.Onuki, M.Nishikawa, M.Morishita, K.Takayama
- Journal Title
  
  Int.J.Pharm. 349
  
  Pages: 47-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Development of photo- cross-linked polyacrylic acid hydrogel as an adhesive for dermatologocal patches : Involvement of formulation factors in physical properties and pharmacological effects2008
- Author(s)
  Y. Onuki, M. Nishikawa, M. Morishita, K. Takayama
- Journal Title
  
  Int.J.Pharm. 349
  
  Pages: 47-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Evaluation of the reliability of nonlinear optimal solutions in pharmaceuticals using a bootstrap resampling technique in combination with Kohonen's selforganizing maps2008
- Author(s)
  Y.Onuki, K.Ohyama, C.Kaseda, H.Arai, T.Suzuki, K.Takayama
- Journal Title
  
  J.Pharm.Sci. 97
  
  Pages: 331-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Evaluation of the reliability of nonlinear optimal solutions in pharmaceuticals using a boot- strap resampling technique in combination with Kohonen's self-organizing maps2008
- Author(s)
  Y. Onuki, K. Ohyama, C. Kaseda, H. Arai, T. Suzuki, K. Takayama
- Journal Title
  
  J.Pharm.Sci. 97
  
  Pages: 331-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Permeation characteristics of oligoarginine through intestinal epithelium and its usefulness for intestinal peptide drug delivery2008
- Author(s)
  N.Kamei, M.Morishita, J.Ehara, K.Takayama
- Journal Title
  
  J.Control.Release 131巻
  
  Pages: 94-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590042
[Journal Article] Bootstrap re-sampling technique to evaluate the optimal formulation of theophylline tablets predicted by nonlinear response surface method incorporating multivariate spline interpolation2007
- Author(s)
  H. Arai, T. Suzuki, C. Kaseda, K. Takayama
- Journal Title
  
  Chem.Pharm.Bull. 55
  
  Pages: 586-593
- NAID
  110006241822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Bootstrap re-sampling technique to evaluate the optimal formulation of theophylline tablets predicted by nonlinear response surface method incorporating multivariate spline interpolation2007
- Author(s)
  H.Arai, T.Suzuki, C.Kaseda, K.Takayama
- Journal Title
  
  Chem.Pharm.Bull. 55
  
  Pages: 586-593
- NAID
  110006241822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590045
[Journal Article] Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats2006
- Author(s)
  T.Goto, M.Morishita, N.J.Kavimandan, K.Takayama, N.A.Peppas
- Journal Title
  
  J.Pharm.Sci. 95
  
  Pages: 462-469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Influence of pressure sensitive adhesive properties on release of formoterol fumarate from matrix patches2006
- Author(s)
  I.Kakubari, J.Kawakami, T.Takayasu, H.Yamauchi, S.Takayama, K.Takayama
- Journal Title
  
  Material Technology 24
  
  Pages: 339-344
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] The mode of promoting activity of O-ethylmenthol as a transdermal absorption enhancer2006
- Author(s)
  Y.Obata, Y.Maruyama, K.Takayama
- Journal Title
  
  Pharm.Res. 23
  
  Pages: 392-400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Characterization of insulin protection properties of complexation hydrogels in gastric and intestinal enzyme fluids,2006
- Author(s)
  T.Yamagata, M.Morishita, N.J.Kavimandan, K.Nakamura, Y.Fukuoka, K.Takayama, N.A.Peppas
- Journal Title
  
  J.Controlled Rel. 112
  
  Pages: 343-349
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Formulation and evaluation of ethylene-vinyl acetate copolymer matrix patches containing formoterol fumarate2006
- Author(s)
  I.Kakubari, N.Shinkai, J.Kawakami, A.Uruno, T.Takayasu, H.Yamauchi, S.Takayama, K.Takayama
- Journal Title
  
  Chem.Pharm.Bull. 29
  
  Pages: 513-516
- NAID
  110005602133
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Effect of pulverization and dehydration on the pharmaceutical properties of calcium lactate pentahydrate tablets,2006
- Author(s)
  Y.Sakata, S.Shiraishi, K.Takayama, M.Otsuka
- Journal Title
  
  Colloids Surf.B : Biointerf 51
  
  Pages: 149-156
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Novel oral insulin delivery systems based on complexation polymer hydrogels : Single and multiple administration studies in type 1 and 2 diabetic rats2006
- Author(s)
  M.Morishita, T.Goto, K.Nakamura, A.M.Lowman, K.Takayama, N.A.Peppas
- Journal Title
  
  J.Controlled Rel. 110
  
  Pages: 587-594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Combined effects of ethanol and L-menthol on hairless rat stratum corneum investigated by synchrotron X-ray diffraction2006
- Author(s)
  Y.Obata, I.Hatta, N.Ohta, N.Kunizawa, N.Yagi, K.Takayama
- Journal Title
  
  J.Controlled Rel. 115
  
  Pages: 275-279
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Effect of temperature-increase rate on drug release characteristics of dextran microspheres prepared by emulsion solvent evaporation process2006
- Author(s)
  Y.Miyazaki, Y.Onuki, S.Yakou, K.Takayama
- Journal Title
  
  Int.J.Pharm. 324
  
  Pages: 144-151
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] In vivo drug release from hydrophilic dextran tablets capable of forming polyion complex2006
- Author(s)
  Y.Miyazaki, Y.Tanaka, S.Yakou, K.Takayama
- Journal Title
  
  J.Controlled Rel. 114
  
  Pages: 47-52
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Effects of ethylcellulose and 2-octyldodecanol additives on skin permeation and irritation with ethylene-vinyl acetate copolymer matrix patches containing formoterol fumarate,2006
- Author(s)
  I.Kakubari, H.Sasaki, T.Takayasu, H.Yamauchi, S.Takayam, K.Takayama
- Journal Title
  
  Chem.Pharm.Bull. 29
  
  Pages: 1717-1722
- NAID
  110005664016
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Multivariate spline interpolation as a novel method to optimize pharmaceutical formulation2004
- Author(s)
  K.Takayama
- Journal Title
  
  Pharmazie 59
  
  Pages: 392-395
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590035
[Journal Article] Multivariate spline interpolation as a novel method to optimize pharmaceutical formulations2004
- Author(s)
  K.Takayama
- Journal Title
  
  Pharmazie 59
  
  Pages: 392-395
- Data Source
  KAKENHI-PROJECT-16590035
[Patent] 経鼻投与用医薬組成物2012
- Inventor(s)
  森下真莉子,高山幸三,井田伸夫,青木孝夫
- Industrial Property Rights Holder
  東レ株式会社
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-10-29
- Data Source
  KAKENHI-PROJECT-23590056
[Patent] 両親媒性ペプチド含有医薬組成物2012
- Inventor(s)
  森下真莉子,高山幸三,西尾玲士,井田伸夫
- Industrial Property Rights Holder
  東レ株式会社
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-09-12
- Overseas
- Data Source
  KAKENHI-PROJECT-23590056
[Patent] 経鼻投与用医薬組成物2012
- Inventor(s)
  森下真莉子,高山幸三,井田伸夫,青木孝夫
- Industrial Property Rights Holder
  東レ株式会社
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-08-31
- Data Source
  KAKENHI-PROJECT-23590056
[Patent] 医薬組成物2012
- Inventor(s)
  森下真莉子,高山幸三,井田伸夫,青木孝夫
- Industrial Property Rights Holder
  東レ株式会社
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-10-12
- Overseas
- Data Source
  KAKENHI-PROJECT-23590056
[Patent] 経鼻投与用医薬組成物2012
- Inventor(s)
  森下真莉子,高山幸三,井田伸夫,青木孝夫
- Industrial Property Rights Holder
  東レ株式会社
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23590056
[Patent] 経鼻投与用医薬組成物2011
- Inventor(s)
  森下真莉子,高山幸三,井田伸夫,青木孝夫
- Industrial Property Rights Holder
  東レ株式会社
- Industrial Property Rights Type
  特許
- Acquisition Date
  2011-04-23
- Overseas
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] 錠剤内部残留応力の一般回帰モデリングによる重要品質特性の予測2019
- Author(s)
  高山幸三
- Organizer
  Discovery Summit Tokyo 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08252
[Presentation] 有限要素法による刻印錠の応力集中分布解析2019
- Author(s)
  森田直杜，佐藤翼，小幡誉子，前田吉晴，大前輝芳，高山幸三
- Organizer
  第36回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08252
[Presentation] X線コンピュータトモグラフによる錠剤の内部構造解析2019
- Author(s)
  佐藤香月，佐藤翼，藤堂浩明，高山幸三，杉林堅次
- Organizer
  第36回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08252
[Presentation] 湿式顆粒圧縮法による錠剤製造工程への科学的理解を目的とした構造方程式モデリングの導入2019
- Author(s)
  片山博貴，藤堂浩明，杉林堅次，高山幸三
- Organizer
  第44回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-17K08252
[Presentation] Modeling of quantitative relationships between physicochemical properties of APIs and tablet properties using a random forest2018
- Author(s)
  Y. Hayashi, Y. Nakano, Y. Marumo, A. Kosugi, S. Kumada, D. Hirai, K. Takayama, Y. Onuki
- Organizer
  Compaction Simulation Forum 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08252
[Presentation] 残留応力分布に基づく医療用錠剤の品質特性予測2015
- Author(s)
  高山幸三
- Organizer
  Nisshin Engineering Particle Technology International Seminar (NEPTIS-24)
- Place of Presentation
  東京
- Year and Date
  2015-10-30
- Invited
- Data Source
  KAKENHI-PROJECT-26460047
[Presentation] アセトアミノフェン含有オーバル錠の調製における工程変数の最適化2015
- Author(s)
  松本智徳，上原直人，大貫義則，小幡誉子，高山幸三
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26460047
[Presentation] 顆粒の粒子径がDPCモデルおよび錠剤内残留応力分布に及ぼす影響2015
- Author(s)
  林祥弘，大貫義則，高山幸三
- Organizer
  第32回製剤と粒子設計シンポジウム
- Place of Presentation
  豊橋
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26460047
[Presentation] Visualization of tableting process based on the self-organizing map and the finite element analysis2015
- Author(s)
  K. Takayama
- Organizer
  Faculty of Medicine, Research Week 2015 (FOMRW2015)
- Place of Presentation
  Kuala Lumpur, Malaysia
- Year and Date
  2015-05-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460047
[Presentation] 楕円錠の処方最適化と信頼性評価2015
- Author(s)
  根本遥，乙黒沙織，岡田信人，大貫義則，小幡誉子，高山幸三
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26460047
[Presentation] 有限要素法による割線錠の分割シミュレーションと実験的検証2015
- Author(s)
  岡田信人，小幡誉子，高山幸三，三浦孝広
- Organizer
  第32回製剤と粒子設計シンポジウム
- Place of Presentation
  豊橋
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26460047
[Presentation] EGOによるテオフィリン含有口腔内崩壊錠の最適設計2014
- Author(s)
  大嶋英津子、林祥弘、今西祐、西口純也、綛田長生、西村順二、高山幸三
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] SVMおよび GRNN による錠剤特性の高精度予測2014
- Author(s)
  谷口真歩、林祥弘、前田仁、大貫義則、小幡誉子、高山幸三
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 設計変数 -残留応力分布 -製剤特性間の相関モデルの同定2014
- Author(s)
  林祥弘、三浦孝宏、乙黒沙織、大貫義則、小幡誉子、高山幸三
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 高度不飽和脂肪酸のGLP-1分泌促進作用を介した新規糖尿病治療法の開発2013
- Author(s)
  亀井敬泰,志田貴之,田中智大,高山幸三,武田真莉子
- Organizer
  第2回日本くすりと糖尿病学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] Cell-penetrating peptides in oral delivery systems for insulin2013
- Author(s)
  Nielsen EJB, Yoshida S, Kamei N, Rahbek UR, Pedersen BR, Takayama K, Takeda-Morishtia M.
- Organizer
  The 40th Annual Meeting and Exposition, the Controlled Release Society
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] 錠剤製造工程がDrucker-Prager Capモデルに及ぼす影響2013
- Author(s)
  林祥弘,三浦孝広,松永大典,島田泰拓,大貫義則,小幡誉子,高山幸三
- Organizer
  日本薬学会133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 打錠用杵の表面処理によるスティッキング現象の改善2013
- Author(s)
  上原直人,林祥弘,湯汲省吾,島田泰拓,國次真輔,大貫義則,小幡誉子,高山幸三
- Organizer
  製剤機械技術学会第23回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 湿式顆粒圧縮法により製した錠剤における設計変数-顆粒物性-錠剤特性の構造分析2013
- Author(s)
  上原直人,林祥弘,大貫義則,小幡誉子,高山幸三
- Organizer
  日本薬学会133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 製造工程変数が錠剤内残留応力分布に及ぼす影響2013
- Author(s)
  林祥弘,三浦孝広,松永大典,島田泰拓,大貫義則,小幡誉子,高山幸三
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation]2013
- Author(s)
  上原直人,岡田信人,林祥弘,大貫義則,小幡誉子,高山幸三
- Organizer
  第19回創剤フォーラム若手研究会
- Place of Presentation
  千葉
- Year and Date
  2013-12-07
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] テラヘルツイメージングによる錠剤内密度分布の評価2013
- Author(s)
  林祥弘,高桑真樹,入澤昭好,今村元規,小幡誉子,大貫義則,高山幸三
- Organizer
  第30回製剤と粒子設計シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] イブプロフェン固体分散体製剤の調製と評価2013
- Author(s)
  乙黒沙織,林祥弘,大貫義則,小幡誉子,高山幸三
- Organizer
  日本薬学会133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] Usefulness of cell-penetrating peptides for development of oral insulin delivery systems2013
- Author(s)
  Nielsen EJB, Kamei N, Yoshida S, Takayama K, Takeda-Morishita M.
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] 錠剤処方データベースの構築とその内部構造分析2013
- Author(s)
  谷口真歩,林祥弘,前田仁,大貫義則,小幡誉子,高山幸三
- Organizer
  日本薬学会133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation]2013
- Author(s)
  乙黒沙織,松本智徳,林祥弘,大貫義則,小幡誉子,高山幸三
- Organizer
  第19回創剤フォーラム若手研究会
- Place of Presentation
  千葉
- Year and Date
  2013-12-07
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 膜透過性ペプチドをキャリアとするインスリン経口デリバリーシステムの開発2013
- Author(s)
  岩前瑠衣紗,吉田真也, Nielsen EJB,亀井敬泰,高山幸三,武田(森下)真莉子
- Organizer
  第63回日本薬学会近畿支部大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] 形状の違いによる錠剤内応力分布の変化2013
- Author(s)
  乙黒沙織,林祥弘,三浦孝宏,小幡誉子,大貫義則,高山幸三
- Organizer
  第30回製剤と粒子設計シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] テオフィリン錠をモデルとした処方最適化のための追加実験点の効率的探索2013
- Author(s)
  大嶋英津子、林祥弘、今西祐、西口純也、綛田長生、西村順二、高山幸三
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] Prediction of tablet characteistics from residual stress distribution estimated by the finite element method2013
- Author(s)
  Y. Hayashi, T. Miura, Y. Onuki, Y. Obata, K. Takayama
- Organizer
  3rd Conference on Innovation in Drug Delivery : Advances in Local Drug Delivery
- Place of Presentation
  ピサ(イタリア)
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] ベイズ推定を活用した効率的なデザインスペース構築手法2013
- Author(s)
  前田仁,鈴木達也,高山幸三
- Organizer
  日本薬学会133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] Novel method to construct large-scale design space in lubrication process utilizing Bayesian estimation based on a small-scale design-of-experiment and small sets of large-scale manufacturing data2012
- Author(s)
  J. Maeda, T. Suzuki, K. Takayama
- Organizer
  AAPS Annual Meeting and Exposition
- Place of Presentation
  Chicago, U.S.A.
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 口腔内崩壊錠における設計変数-顆粒物性-錠剤特性の構造分析2012
- Author(s)
  林祥弘,菊地伸吾,大嶋英津子,谷口真歩,高山幸三
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 錠剤処方データベースの構築とサポートベクターマシンによる特性予測2012
- Author(s)
  谷口真歩,林祥弘,前田仁,大貫義則,小幡誉子,高山幸三
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 細胞膜透過ペプチドを利用した経口インスリン送達システムの開発2012
- Author(s)
  吉田真也,森下真莉子,佐藤智美,高山幸三
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] 細胞膜透過ペプチド(CPPs)を利用した脳への薬物送達システムの開発研究2012
- Author(s)
  佐藤智美,森下真莉子,吉田真也,高山幸三
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] 計量化学的技術の製剤設計への応用～口腔内崩壊錠における製造工程の最適化および設計変数-顆粒物性-錠剤特性の構造分析～2012
- Author(s)
  林祥弘、菊地伸吾、大貫義則、小幡誉子、高山幸三
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 有限要素法による錠剤内応力分布の推定2012
- Author(s)
  林祥弘,三浦孝広,松永大典,島田泰拓,高山幸三
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] 自己組織化マップを利用した錠剤処方データベースの内部構造の可視化2012
- Author(s)
  菊地伸吾,川合翔太,荒井宏明,大貫義則,高山幸三
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] Noninvasive peptide and protein delivery systems using cell-penetrating peptides2011
- Author(s)
  Morishita M, Kamei N, Takayama K.
- Organizer
  20^<th> Helsinki Drug Research Congress
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] Evaluation of reliability of border on design space estimated by nonlinear response surface method2011
- Author(s)
  Y. Hayashi, S.Kikuchi, Y. Onuki, K. Takayama
- Organizer
  AAPS Annual Meeting and Exposition
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] rug release mechanism of sustained-release tablet formulations containing Diltiazem hydrochloride using magnetic resonance imaging2011
- Author(s)
  S. Kikuchi, Y. Onuki, H. Kuribayashi, K. Takayama
- Organizer
  AAPS Annual Meeting and Exposition
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] N Cell-penetrating peptides as a novel oral bioavailability enhancer for theraoeutic peptides and proteins : a mechanistic tudy of BA enhancement effects using Caco-2 cell monolayers2011
- Author(s)
  Morishita M, Kamei N, Takayama K.
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] Bootstrap法を用いたメフェナム酸錠の攪拌造粒条件デザインスペースの信頼性評価2011
- Author(s)
  荒井宏明,鈴木達也,矢田修一,脇山尚樹,綛田長生,大貫義則,高山幸三
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] Evaluation of reliability of border on design space estimated by nonlinear response surface method2011
- Author(s)
  Y. Hayashi, S. Kikuchi, Y. Onuki, K Takayama
- Organizer
  2011 AAPS Annual Meeting and Exposition
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] A novel statistical approach in pharmaceutical formulation development2010
- Author(s)
  K.Takayama
- Organizer
  Pharmaceutical Sciences World Congress(PSWC2010)
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] ジルチアゼム塩酸塩放出制御型製剤における設計変数-内在因子-製剤特性の構造分析2010
- Author(s)
  菊地伸吾、大貫義則、高山幸三
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] ブートストラップ法とKohonenの自己組織化マップを併用した非線形同時最適解の信頼性評価方法:同時最適解における個々の実験点の寄与2010
- Author(s)
  大貫義則、菊地伸吾、安田昭仁、高山幸三
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] 細胞膜透過ペプチドによるインスリン細胞膜透過促進機構の解明2010
- Author(s)
  山本修一、森下真莉子、高山幸三
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] 小腸粘膜免疫細胞ターゲティング型経口ワクチンの開発2010
- Author(s)
  吉田美亜、森下真莉子、國澤純、高山幸三
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] 錠剤処方データベースの構築と一般回帰ニューラルネットワークによる特性予測2010
- Author(s)
  川合翔太、菊地伸吾、高山幸三
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] アンサンブルニューラルネットワークによる錠剤処方の特性予測:データベースの拡充と新規アルゴリズムの導入2010
- Author(s)
  高垣恵介、荒井宏明、高山幸三
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] 計量薬学的手法による製剤処方の最適化2010
- Author(s)
  高山幸三
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] ベイジアンネットワークを用いた固体分散体の設計変数と製剤特性間のモデル化2010
- Author(s)
  林祥弘、菊地伸吾、高山幸三
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] Novel Statistical Approach in Pharmaceutical Formulation Development2010
- Author(s)
  K. Takayama
- Organizer
  FIP PSWC/AAPS Annual Meeting(招待講演)
- Place of Presentation
  ew Orleans, Louisiana, USA
- Data Source
  KAKENHI-PROJECT-23590053
[Presentation] In silico解析による新規Cell penetrating peptidesの開発2010
- Author(s)
  寺澤義明、森下真莉子、井田伸夫、西尾玲士、安田昭仁、高山幸三
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] 逆ミセル型高分子ナノ粒子を利用した新規DDSキャリアの開発2010
- Author(s)
  武藤慧也、森下真莉子、井田伸夫、西尾玲士、安田昭仁、高山幸三
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] BCRP(Breast Cancer Resistance Protein)基質:Sulfasalazineの消化管吸収特性2010
- Author(s)
  森本望、森下真莉子、楠原洋之、藤田卓也、杉山雄一、高山幸三
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] Novel statistical approach in pharmaceutical formulation development2010
- Author(s)
  高山幸三
- Organizer
  2010 FIP Pharmaceutical Sciences World Congress (PSWC)
- Place of Presentation
  New Orleans, U.S.A.
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] 自己組織化マップとベイジアンネットワークを利用したテオフィリン錠剤処方の潜在構造モデリング2010
- Author(s)
  安田昭仁、大貫義則、高山幸三
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] サキナビルに対するリトナビルの薬物動態学的ブースター効果の解析2010
- Author(s)
  都丸充子、森下真莉子、高山幸三、前田和哉、杉山雄一
- Organizer
  第18回肝病態生理研究会
- Place of Presentation
  山形
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] 薄板スプライン補間と自己組織化マップを利用した固形製剤処方の特性クラスタリング2009
- Author(s)
  安田昭仁、大貫義則、荒井宏明、高山幸三
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] A novel statistical method to setup the design space for the optimal formulations of pharmaceutical products2009
- Author(s)
  菊地伸吾, 高山幸三
- Organizer
  The 2nd Joint Symposium on Future Prospect of Pharmaceutical Sciences 2009
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] 錠剤処方データベースの構築とアンサンブルニューラルネットワークによる特性予測2009
- Author(s)
  高垣恵介、荒井宏明、高山幸三
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] ジルチアゼム塩酸塩長期徐放システムの最適設計2009
- Author(s)
  菊地伸吾、高山幸三
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] 細胞膜透過ペプチドによるインスリン吸収促進作用のCaco-2単層膜における評価2009
- Author(s)
  山本修一、森下真莉子、亀井敬泰、高山幸三
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] Effect of an experimental design for evaluating the nonlinear optimal formulation of theophylline tablets using a bootstrap resampling technique2009
- Author(s)
  H.Arai, T.Suzuki, H.Nakagami, C.Kaseda, K.Takayama
- Organizer
  2009 AAPS Annual Meeting and Exposition
- Place of Presentation
  Los Angels, U.S.A.
- Year and Date
  2009-11-08
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] 機能性ペプチドによるバイオ薬物の消化管吸収改善とそのメカニズムの検討2009
- Author(s)
  亀井敬泰、森下真莉子、高山幸三
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] Evaluation of pharmaceutical excipients as inhibitors of intestinal efflux transporters2009
- Author(s)
  M.Morishita, T.Yamagata, H.Kusuhara, Y.Sugiyama, K.Takayama
- Organizer
  BioMedical Transporters 2009
- Place of Presentation
  Thun, Switzerland
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] 実験計画法による実験点の抽出と解析2009
- Author(s)
  高山幸三
- Organizer
  第2回標準処方研究フォーラム
- Place of Presentation
  名古屋
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] バイオ薬物の経口吸収促進ツールとなる細胞膜透過ペプチドのInsilico解析に基づく開発研究2009
- Author(s)
  寺澤義明、森下真莉子、井田伸夫、西尾玲士、高山幸三
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] BCRP(Breast Cancer Resistance Protein)基質薬物の消化管吸収を改善する阻害剤の探索2009
- Author(s)
  森本望、森下真莉子、楠原洋之、杉山雄一、高山幸三
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] 細胞膜透過ペプチドの消化管バイオ薬物吸収促進機構における分子間相互作用の寄与2008
- Author(s)
  亀井敬泰、森下真莉子、高山幸三
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] モンテカルロシュミレーションによる製剤処方非線形最適解の信頼性評価2008
- Author(s)
  菊地伸吾、高山幸三
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] バイオ医薬の経鼻吸収における細胞膜透過性ペプチドの有用性評価2008
- Author(s)
  枝佳美、El-Sayed Kafagy、森下真莉子、高山幸三
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] Effect of cell-penetrating peptides (CPPs) on the nasal absorption of insulin2008
- Author(s)
  E.S.Khafagy, M.Morishita, K.Takayama
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] バイオ薬物の消化管吸収における細胞膜透過性ペプチドの有効性の評価2008
- Author(s)
  池野洋平、森下真莉子、亀井敬泰、高山幸三
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590042
[Presentation] 脂質ラフトの形成機構解明を目的とした脂質二重膜モデルの膜物性評価2008
- Author(s)
  大貫義則、高山幸三
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] Computer-aided design and optimization for pharmaceutical formulations2007
- Author(s)
  高山幸三
- Organizer
  The 3rd Annual Pharmaceutical Sciences World Congress
- Place of Presentation
  Amsterdam, The Netherlands
- Year and Date
  2007-04-22
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] Computer-aided design and optimization for pharmaceutical formulations2007
- Author(s)
  K. Takayama
- Organizer
  The 3^<rd> Annual Pharma- ceutical Sciences World Congress
- Place of Presentation
  Amsterdam, The Netherlands
- Year and Date
  2007-04-22
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] Anovel approach using functional peptides for efficient intestinal absorption of peptide and protein drugs2007
- Author(s)
  M. Morishita, N. Kamei, K. Takayama
- Organizer
  The 6^<th> Retrometabolism Based Drug Design and Targeting Conference
- Place of Presentation
  Budapest, Hungary
- Year and Date
  2007-06-04
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] ブートストラップ法と自己組織化マップの併用による製剤処方最適解の信頼性評価2006
- Author(s)
  大山康一, 紹田長生, 大貫義則, 森下真莉子, 高山幸三
- Organizer
  日本薬剤学会第21年会
- Place of Presentation
  金沢
- Year and Date
  2006-03-16
- Data Source
  KAKENHI-PROJECT-19590045
[Presentation] 打錠用杵の表面処理によるスティッキング現象の改善
- Author(s)
  上原直人、湯汲省吾、島田泰拓、國次真輔、大貫義則、小幡誉子、高山幸三
- Organizer
  第31回製剤と粒子設計シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-26460047
[Presentation] Computer-aided design and optimization for pharmaceutical products
- Author(s)
  K. Takayama
- Organizer
  The 1st International Conference on Pharmaceutics and Pharmaceutical Sciences
- Place of Presentation
  Surabaya, Indonesia
- Year and Date
  2014-11-14 – 2014-11-15
- Invited
- Data Source
  KAKENHI-PROJECT-26460047
[Presentation] Cell-penetrating peptides in oral delivery systems for insulin
- Author(s)
  Nielsen EJB, Yoshida S, Kamei N, Rahbek UR, Pedersen BR, Takayama K, Takeda-Morishtia M
- Organizer
  The 40th Annual Meeting and Exposition, the Controlled Release Society
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-23590056
[Presentation] CAEシミュレーションによる錠剤内密度分布の推定と錠剤特性への影響
- Author(s)
  乙黒沙織、大貫義則、小幡誉子、高山幸三
- Organizer
  第31回製剤と粒子設計シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-26460047

1. NAGAI Tsuneji (40061270)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. MORISHITA Mariko (70257096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 41 results
3. HIGASIYAMA Kimio (70101582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OHNISHI H. (00160565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. UEDA H. (20061301)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MACHIDA Y. (00061292)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUZUKI Tsutomu (90130757)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SUGIBAYASHI Kenji (00105834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HASEGAWA Tetsuya (50245148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIBASHI Takuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大貫義則

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Takayama Kozo 高山 幸三

TAKAYAMA Kozo 高山 幸三

TAKAYAMA K. 高山 幸三

Research Projects

Research Products

Co-Researchers

Combined use of deep learning and CAE simulation for design and optimization of pharmaceutical productsPrincipal Investigator

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Establishment of in silico pharmaceutical product design based on CAE simulationPrincipal Investigator

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Creaton of tablet database and visulalization of its internal structurePrincipal Investigator

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Development of non-invasive delivery of biopharmaceuticals equipped with novel membrane permeation technology and their translational research

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Development research of next generation type of non-invasive DDS using delivery carrier

Principal Investigator

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Development of in silico prediction technique for pharmaceutical design and optimizationPrincipal Investigator

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Optimization of transdermal and transmucosal drug delivery systems utilizing thin-plate spline interpolationPrincipal Investigator

Principal Investigator

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Optimization of transdermal and transmucosal drug delivery systems utilizing artificial neural networksPrincipal Investigator

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Utility of the three-dimensional cultured human skin model as a tool to evaluate rapid determination of skin permeation of drag and skin irritation.

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Promoting activity of menthol derivatives containing sulfur atom on the percutaneous absorption of drugs

Principal Investigator

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Evaluation of percutaneous absorption promoters by means of solid fractal analysis of skin stratum corneumPrincipal Investigator

Principal Investigator

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鶏胚血管像のフラクタル解析による経皮吸収促進剤の刺激性の評価Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Development of novel percutaneous absorption promoters

Principal Investigator

Takayama Kozo 高山幸三

TAKAYAMA Kozo 高山幸三

TAKAYAMA K. 高山幸三

[Book] 医療・医学・薬学におけるSOMの応用第18章固形製剤の開発2015

[Book] 薬剤学概史製剤開発への計量化学的手法の導入2015

[Book] ドラッグデリバリーシステム第2章量的制御2012

[Book] 造粒・打錠プロセスにおける適正操作とトラブル対策ノウハウ集第7章実験計画法による製剤の処方設計・最適化2010

[Book] 最新・経皮吸収～開発の基礎から申請のポイントまで～(第2章経皮吸収型製剤の製剤設計)2008

[Book] 最新・経皮吸収～開発の基礎から申請のポイントまで～第2章経皮吸収型製剤の製剤設計2008

[Book] 基礎から学ぶ製剤化のサイエンス第1章物質の溶解2008

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