KUROHMRU Masamichi 九郎丸正道

Researcher Number	00148636
Affiliation *help	2016 – 2017 : 東京大学, 大学院農学生命科学研究科(農学部), 教授 2016 : 東京大学, 大学院農学生命科学研究科, 教授 2010 – 2015 : The University of Tokyo, 農学生命科学研究科, 教授 2007 – 2011 : 東京大学, 大学院・農学生命科学研究科, 教授 2008 – 2009 : 東大, 農学生命科学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Basic veterinary science/Basic zootechnical science / 畜産学(含草地学) / Applied animal science / Applied animal science / 基礎獣医学 Except Principal Investigator Basic veterinary science/Basic zootechnical science / Basic veterinary science/Basic zootechnical science / 基礎獣医学 / Animal production science / Cardiovascular surgery … More
Keywords	Principal Investigator セルトリ細胞 / 精母細胞 / 精細胞 / ビメンチン / 精祖細胞 / レクチン / ライディッヒ細胞 / 精子細胞 / NGF / セルトリ細胞培養系 … More Except Principal Investigator マウス / SOX17 / モデル動物 / 精巣 / 精細胞 / 膵臓 / spermatic cord / spermatogenic cells / C57BL / ツパイ / 精細管 / ミトコンドリアDNA / IVF / Smad2 / Smad3 / 肝臓 / 精巣索 / 胆管 / mouse / SOX18 / 精子 / 精祖細胞 / Blood protein polymorphism, / Conservation of Wildlife / 重症虚血肢 / spermatozoa / 卵子透明帯 / テストステロン / testicular cord / ハムスター / 性転換 / Tragulus javanicus / testis / Tragulus napu / 支持細胞 / Sertoli cells / 種間解析 / ナノメディシン / 反芻動物 / lectin histochemistry / DNA / heterogeneity / 胎仔 / 免疫組織化学 / mouse testis / 主要組織適合型複合体 / ジャワマメジカ / Evolution / hormone / craniometry / MHC class II / 怪網 / ドラッグデリバリーシステム / 実験的腹腔内精巣 / phylogeny / spermatogenesis / 卵精巣 / 性索形成 / 性比 / 生殖細胞系列 / Bisphenol-A / 生殖細胞 / 核磁気共鳴イメージング / FOLLISTATIN / 胆嚢 / hypotaurine / sex cord formation / Risso's dolphin / ビスフェノールA / glycoprotein / セルトリ細胞培養系 / species analysis / short photoperiod / zona pellucida / 動物種保存 / PANCREATIC ISLET / 肝臓形成 / in vitro培養系 / アクチビン / Rare animal / 腹腔内精巣 / 精母細胞 / エストロジェン / ハイポタウリン / spermatogonia / 血清蛋白 / seminiferous eitherium / 心筋細胞 / ハタネズミ / 精上皮 / ACTIVIN / immunohistochemistry / 末分化生殖腺器官培養系 / 性分化 / 胆道閉鎖 / Mitochondria DNA Monoclonal antibody, / 精原幹細胞 / 精子発生 / spermatogenic cell / ラット / Mouse deer / germ cell / 対向流輸送 / イルカ / Tupai, / 希少動物 / マメジカ / hamster / 受容体ノックアウト / Germ cell line, / 進化 / Ruminant / 遺伝子改変マウス / 性的２型 / ミトコンドリア / 血液タンパク多型 / 獣医学 / 側副血管 / 性染色体 / 先体酵素 / 蔓状静脈叢 / OVARY / 6マウス / ハプロ不全 / TESTIS / 血管新生療法 / 急性下肢虚血 / ハナゴンドウ / 頭蓋計測 / 複合糖質 / organ culture of undifferentiated gonad / Smadファミリー / マウス重症虚血肢モデル / 内分泌細胞 / serum protein / モトコンドリアDNA / セルトリ細胞 / Knockout mice / 応用動物 / 血管形成 / sexual differentiation / Cardiac myocyte, / 外因性内分泌攪乱物質 / rat / countercurrent transfer / mitochondrial DNA / 未分化生殖腺器官培養系 / 蔓状靜脈叢 / lectin / オーファン受容体 / ドラッグデリバリー / 応用動物学 / PAS反応 / PAS-reaction / estrogen / カルシウムイオノフォア / ランゲルハンス島 / Gut endocrine cell, / ホルモン / primary Sertoli cell culture / cryptic testis / 系統進化 / 胆道閉鎖症 / 精索 / pampiniform plexus / 消化管内分泌細胞 / field vole / tupai / zona-hydrolysing enzyme / 磁網 / insemination / レクチン / in vitro culture system / 三次元形態解析 / bottlenose dolphin / 異種間受精阻止 / spermatocyte / 性化 / 6 mouse / 哺乳類 / リアルタイム解析 / rete mirabile / 熱ショックタンパク質(HSPs) / バンドウイルカ / 疾患モデル / 熱帯産動物 / acrosome reaction / animal model / 短日条件 / ホリスタチン / Heat Shock Proteins / IL-1β / モノクローナル抗体 / レクチン組織化学 / セルトリ細胞初代培養系 / angiogenesis / オオマメジカ / 卵巣 Less

哺乳類の生殖腺の性的２型の維持と破綻の分子基盤の解明Ongoing
- Principal Investigator
  
  金井克晃
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
季節繁殖動物における精原幹細胞ニッチシステムの解析Ongoing
- Principal Investigator
  
  恒川直樹
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Animal production science
- Research Institution
  Nihon University
Novel approach to acute limb ischemia with nano-DDS
- Principal Investigator
  
  Nishiyama Ayako
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  The University of Tokyo
胆嚢・胆管の形態形成・再生能と先天性疾患の分子機構の解明Ongoing
- Principal Investigator
  
  金井克晃
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Crucial roles of SOX17 in liver-gallbladder-pancreas development
- Principal Investigator
  
  KANAI Yoshiakira
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Analysis of the toxicological effects of phthalate esters on testes by administration, culture and transplantation methodsPrincipal Investigator
- Principal Investigator
  
  KUROHMARU Masamichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
哺乳動物の精子の性差の分子基盤の解明
- Principal Investigator
  
  金井克晃
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Crucial roles of SOX17 in fetal liver development
- Principal Investigator
  
  KANAI Yoshiakira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
雄性生殖幹細胞移植法及び精細管移植法を用いた生殖毒性試験法の確立Principal Investigator
- Principal Investigator
  
  九郎丸正道
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Redundant roles of Sox17 and Sox18 on cardiovascular development in mice
- Principal Investigator
  
  KANAI Yoshiakira
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Morphological and molecular analyses on testiculture tissuer at hibernation periodPrincipal Investigator
- Principal Investigator
  
  KUROHMARU Masamichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
内分泌攪乱物質による生殖毒性評価システムの構築:構造生物学・細胞生物学的リアルタイム評価法の確立
- Principal Investigator
  
  宮本元, 眞鍋昇
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Establishment of testis in vitro assay system for risk assessment of endocrine disrupters
- Principal Investigator
  
  HAYASHI Yoshihiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  THE UNIVERSITY OF TOKYO
Physiological and ecological investigation of mouse deer and their conservation in Malaysia.
- Principal Investigator
  
  FUKUTA Katsuhiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Nagoya University
Analysis of mechanism of changes in function and size of golden hamster testis with special reference to TGF-β signal transduction
- Principal Investigator
  
  HAYASHI Yoshihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  THE UNIVERSITY OF TOKYO
Risk evaluation on endocrine disruptors using some testicular tissue culture systemsPrincipal Investigator
- Principal Investigator
  
  KUROHMARU Masamichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  THE UNIVERSITY OF TOKYO
Cellular and molecular analysis of cryptic testes in dolphins
- Principal Investigator
  
  HAYASHI Yoshihiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Phylogenetical study of tupaiidae in Thailand and Indonesia
- Principal Investigator
  
  YAMADA Junzo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Analysis of inhibitory mechanism of fertilization between different species
- Principal Investigator
  
  HAYASHI Yoshihiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Establishment of accurate in vitro measurement for testicular toxic tePrincipal Investigator
- Principal Investigator
  
  KUROHMARU Masamichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
精巣における各種ホルモン・成長因子受容体の発現の解析Principal Investigator
- Principal Investigator
  
  九郎丸正道
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
食虫目トガリネズミ科動物における生殖戦略の相違に基づく精巣組織の適応変化Principal Investigator
- Principal Investigator
  
  九郎丸正道
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
加齢に伴う生殖細胞分化能および精巣組織微細形態の変化に関する研究Principal Investigator
- Principal Investigator
  
  九郎丸正道
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Studies on the origin and evolution of tupai in Thailand
- Principal Investigator
  
  NISHIDA Takao
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Nihon University
ビタミンA欠乏ハムスターを用いた精細管ステージ同期化実験系の確立とその機構解明Principal Investigator
- Principal Investigator
  
  九郎丸正道
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  畜産学(含草地学)
- Research Institution
  The University of Tokyo
Functional participation in endocrine system : activin-follistsatin interaction
- Principal Investigator
  
  HAYASHI Yoshihiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  基礎獣医学
- Research Institution
  The University of Tokyo
精子形成不全時におけるセルトリ細胞の細胞骨格の分布と動態に関する研究Principal Investigator
- Principal Investigator
  
  九郎丸正道
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  The University of Tokyo
精細胞とセルトリ細胞の相互認識機構に関する超微形態学的・組織細胞化学的研究Principal Investigator
- Principal Investigator
  
  九郎丸正道
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  畜産学(含草地学)
- Research Institution
  The University of Tokyo
Establishment of in vitro culture system of seminiferous epitherium and clarifying the mechanism of spermatogenesis
- Principal Investigator
  
  HAYASHI Yoshihiro
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  基礎獣医学
- Research Institution
  The University of Tokyo
Functional Morphology of Countercurrent Transfer System
- Principal Investigator
  
  NISHIDA Takao
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  畜産学(含草地学)
- Research Institution
  Nihon University
  The University of Tokyo
Mechanism for the Formation of Seminiferous Tubules in Mammals
- Principal Investigator
  
  HAYASHI Yoshihiro
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  University of Tokyo

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Anatomy of the murine hepatobiliary system: A whole-organ-level analysis using a transparency method.2016
- Author(s)
  *Higashiyama H, Sumitomo H, Ozawa A, Igarashi H, Kurohmaru M, *Kanai Y.
- Journal Title
  
  Anatomical Record
  
  Volume : 29 Pages : 161-172
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24228005
[Journal Article] In vivo dynamics of GFRα1-positive spermatogonia stimulated by GDNF signals using a bead transplantation assay2016
- Author(s)
  Uchida A, Kishi K, Aiyama Y, Miura K, Takase HM, Suzuki H, Kanai-Azuma M, Iwamori T, Kurohmaru M, Tsunekawa N, Kanai Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 476 Pages : 546-552
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J10266, KAKENHI-PROJECT-14J09465, KAKENHI-PROJECT-15K07688, KAKENHI-PROJECT-15K21217
[Journal Article] A Niche for GFRalpha1-Positive Spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes2015
- Author(s)
  Aiyama, Y. Tsunekawa, N. Kishi, K. Kawasumi, M. Suzuki, H. Kanai-Azuma, M. Kurohmaru, M. Kanai, Y.
- Journal Title
  
  Stem Cells
  
  Volume : 33 Pages : 2811-2824
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07688, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26112508, KAKENHI-PUBLICLY-26114504, KAKENHI-PROJECT-24228005, KAKENHI-PROJECT-15J10266
[Journal Article] Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos.2015
- Author(s)
  Uemura M, Igarashi H, Ozawa A, Tsunekawa N, Kurohmaru M, Kanai-Azuma, M, *Kanai Y.
- Journal Title
  
  J Vet Med Sci
  
  Volume : 77 Pages : 587-591
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24228005
[Journal Article] Single administration of butylparaben induces spermatogenic cell apoptosis in prepubertal rats.2014
- Author(s)
  Alam MS, Ohsako S, Kanai Y, and Kurohmaru M.
- Journal Title
  
  Acta Histochemical
  
  Volume : 116 Pages : 474-480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23310044, KAKENHI-PROJECT-24228005, KAKENHI-PUBLICLY-25132703, KAKENHI-PUBLICLY-26114504, KAKENHI-PROJECT-23658237
[Journal Article] A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads.2014
- Author(s)
  Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, Tsunekawa N, Ozawa A, Aiyama Y, Yoneda A, Suzuki H, Saito M, Picard JY, Kohno K, Kurohmaru M, Kanai-Azuma M, Kanai Y.
- Journal Title
  
  Reproduction
  
  Volume : 148
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228005, KAKENHI-PUBLICLY-25132703, KAKENHI-PROJECT-25830061, KAKENHI-PUBLICLY-26112508, KAKENHI-PUBLICLY-26114504, KAKENHI-PROJECT-24228002
[Journal Article] Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice.2013
- Author(s)
  Uemura M, Ozawa A, Nagata T, Kurasawa K, Tsunekawa N, Nobuhisa I, Taga T, Hara K, Kudo A, Kawakami H, Saijoh Y, Kurohmaru M, Kanai-Azuma M, Kanai Y.
- Journal Title
  
  Development
  
  Volume : 140(3) Pages : 639-648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248034, KAKENHI-PROJECT-22590193, KAKENHI-PROJECT-23570250, KAKENHI-PROJECT-24228005, KAKENHI-PROJECT-24300119, KAKENHI-PROJECT-24500485, KAKENHI-PLANNED-22130008, KAKENHI-PROJECT-13J07573
[Journal Article] Heterogeneity in sexual bipotentiality and plasticity of granulosa cells in developing mouse ovaries.2013
- Author(s)
  Harikae K, Miura K, Shinomura M, Matoba S, Hiramatsu R, Tsunekawa N, Kanai-Azuma M, Kurohmaru M, Morohashi K, Kanai Y.
- Journal Title
  
  J Cell Sci
  
  Volume : 126 Pages : 2834-2844
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228005, KAKENHI-PROJECT-24500485, KAKENHI-PUBLICLY-25132703, KAKENHI-PUBLICLY-23132504, KAKENHI-PROJECT-13J08308
[Journal Article] Dynamics of GFRα1-positive spermatogonia at the early stages of colonization in the recipient testes of W/Wν male mice.2012
- Author(s)
  Nagai R, Shinomura M, Kishi K, Aiyama Y, Harikae K, Sato T, Kanai-Azuma M, Kurohmaru M, Tsunekawa N, Kanai Y.
- Journal Title
  
  DevDyn
  
  Volume : 241(8) Pages : 1374-1384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248034, KAKENHI-PROJECT-24228005, KAKENHI-PUBLICLY-23116702, KAKENHI-PUBLICLY-23132504, KAKENHI-PROJECT-12J07506
[Journal Article] Cyclical and patch-like GDNF distribution along the basal surface of sertoli cells in mouse and hamster testes.2011
- Author(s)
  T. Sato, Y. Aiyama, M. Ishii-Inagaki, K. Hara, N. Tsunekawa, K. Harikae, M. Uemura-Kamata, M. Shinomura, X. B. Zhu, S. Maeda, et al.
- Journal Title
  
  PLoS ONE
  
  Volume : 6
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20116004, KAKENHI-PROJECT-21248034, KAKENHI-PUBLICLY-23116702, KAKENHI-PUBLICLY-23132504, KAKENHI-PROJECT-22657058
[Journal Article] Di(n-butyl)phthalate induces vimentin filaments disruption in rat Sertoli cells : a possible relation with spermatogenic cell apoptosis2010
- Author(s)
  Alam, M.S., Ohsako, S., Tay, T.W., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Journal Title
  
  Anatomia, Histologia, Embryologia (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Single administration of di(n-butyl)phthalate delays spermatogenesis in prepubertal rats2010
- Author(s)
  Alam, M.S., Andriana, B.B., Tay, T.W., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Journal Title
  
  Tissue and Cell (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Effects of di-iso-butyl phthalate on testes of prepubertal rats and mice2010
- Author(s)
  Zhu, X.O., Tay, T.W., Andriana, B.B., Alam, M.S, Choi, E.K., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Journal Title
  
  Okajimas Folia Anatomica Japonica 86(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : a possible estrogenic effect of di(n-butyl)phthalate2010
- Author(s)
  Alam, M.S., Ohsako, S., Matsuwaki, T., Zhu, X.O., Tsunekawa, N., Kanai, Y., Sone, H., Tohyama, C., Kurohmaru, M.
- Journal Title
  
  Reproduction 139
  
  Pages : 427-437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Effects of di-iso-butyl phthalate on testes of prepubertal rats and mice2010
- Author(s)
  Zhu, X.O., Tay, T.W., Andriana, B.B., Alam, M.S, Choi, E.K., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Journal Title
  
  Okajimas Folia Anatomica Japonica
  
  Volume : 86 Pages : 129-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis.2010
- Author(s)
  Uemura M, Hara K, Shitara H, Ishii R, Tsunekawa N, Miura Y, Kurohmaru M, Taya C, Yonekawa H, Kanai-Azuma M, Kanai Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 391(1) Pages : 357-363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248034
[Journal Article] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : A possible estrogenic effect of di(n-butyl) phthalate2010
- Author(s)
  Alam, M. S., Ohsako, S., Matsuwaki, T., Zhu, X. B., Tsunekawa, N., Kanai, Y., Sone, H., Tohyama, C. and Kurohmaru, M.
- Journal Title
  
  Reproduction
  
  Volume : Vol.139 Pages : 427-437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Di(n-butyl) phthalate induce vimentin filaments disruption in rat Sertoli cells : A possible relation with spermatogenic cell apoptosis2010
- Author(s)
  Alam, M. S., Ohsako, S., Tay, T. W., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
- Journal Title
  
  Anat. Histol. Embryol
  
  Volume : Vol.39 Pages : 186-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Single administration of di(n-butyl) phthalate delays spermatogenesis in prepubertal rats2010
- Author(s)
  Alam, M.S., Andriana, B.B., Tay, T.W., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Journal Title
  
  Tissue and Cell
  
  Volume : 42 Pages : 129-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Di(n-butyl) phthalate induces vimentin filaments disruption in rat Sertoli cells : a possible relation with spermatogenic cell apoptosis2010
- Author(s)
  Alam, M.S., Ohsako, S., Tay, T.W., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Journal Title
  
  Anatomia, Histologia, Embryologia
  
  Volume : 39 Pages : 186-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation.2010
- Author(s)
  Hiramatsu R, Harikae K, Tsunekawa N, Kurohmaru M, Matsuo I, Kanai Y.
- Journal Title
  
  Development
  
  Volume : 137(2) Pages : 303-312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248034
[Journal Article] Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis2009
- Author(s)
  Hara K, Kanai-Azuma M, Uemura M, Shitara H, Taya C, Yonekawa H, Kawakami H, Tsunekawa N, Kurohmaru M, Kanai Y.
- Journal Title
  
  Dev. Biol 330
  
  Pages : 427-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380168
[Journal Article] Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis.2009
- Author(s)
  Hara K, Kanai-Azuma M, Uemura M, Shitara H, Taya C, Yonekawa H, Kawakami H, Tsunekawa N, Kurohmaru M, Kanai Y.
- Journal Title
  
  Dev Biol
  
  Volume : 330(2) Pages : 427-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248034
[Journal Article] A critical time windows of Sry action in gonadal sex differentiation in mice2009
- Author(s)
  Hiramatsu R, Matoba S, Kanai-Azuma M, Tsunekawa N, Katoh-Fukui Y, Kurohmaru M, Morohashi K, Wilhelm D, Koopman P, Kanai Y.
- Journal Title
  
  Development
  
  Volume : 36(1) Pages : 129-138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21248034, KAKENHI-PROJECT-21590354
[Journal Article] A new preparation protocol for measurement of testicular sperm production2008
- Author(s)
  Choi, E. K., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume : Vol.54, No.1 Pages : 90-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] A new preparation protocol for measurement of testicular sperm production2008
- Author(s)
  Choi, E. K., Tsunekawa, N, Kanai, Y., Kurohmaru, M.
- Journal Title
  
  Journal of Reproduction and Development 54
  
  Pages : 90-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos2007
- Author(s)
  Sakamoto Y, Hara K, Kanai-Azuma M, Matsui T, Miura Y, Tsunekawa N, Kurohmaru M, Saijoh Y, Koopman P, Kanai Y.
- Journal Title
  
  Biochem Biophys Res Commun 360(3)
  
  Pages : 539-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380168
[Journal Article] An ultrastructural study on the effects of mono(2-ethylhexyl) phthalate on mice testes : Cell death and sloughing of spermatogenic cells.2007
- Author(s)
  Tay, T.W., Andriana, B.B., Ishii, M., Choi, E.K., Zhu, X.B., Alam, M.S., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Journal Title
  
  Okajimas Folia Anatomica Japonica 83・4
  
  Pages : 123-130
- Data Source
  KAKENHI-PROJECT-17658120
[Journal Article] Potency of testicular somatic environment to support spermatogenesis in XX/Sry transgenic male mice.2007
- Author(s)
  Ishii, M., Tachiwana, T., Hoshino, A., Tsunekawa, N., Hiramatsu, R., Matoba, S., Kanai-Azuma, M., Kawakami, H., Kurohmaru, M., Kanai,Y.
- Journal Title
  
  Development 134・3
  
  Pages : 449-454
- Data Source
  KAKENHI-PROJECT-17658120
[Journal Article] Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice.2006
- Author(s)
  Matsui, M., Kanai-Azuma, M., Hara K., Matoba, S., Hiramatsu, R., Kawakami, H., Kurohmaru, M., Koopman, P., Kanai Y.
- Journal Title
  
  J.Cell Sci. 119 (17)
  
  Pages : 3513-3526
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380175
[Journal Article] Effects of di-iso-butyl phthalate on testes of prepubertal rats and mice
- Author(s)
  Zhu, X. B., Tay, T. W., Andriana, B. B., Alam, M. S., Choi, E. K., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
- Journal Title
  
  Okajimas Folia Anat. Jpn.
  
  Volume : Vol.86, No.4 Pages : 129-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Journal Article] Single administration of di(n-butyl) phthalate delays spermatogenesis in prepubertal rats
- Author(s)
  Alam, M. S., Andriana, B. B., Tay, T. W., Tsunekawa, N., Kanai, Y. and Kurohmaru, M.
- Journal Title
  
  Tissue & Cell
  
  Volume : Vol.42, No.2 Pages : 129-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : a possible estrogenic effect of di(n-butyl)phthalate2009
- Author(s)
  Alam, M.S., Ohsako, S., Matsuwaki, T., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Organizer
  21^<st> Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  東京
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] Induction of spermatogenic cell apoptosis in prepubertal rat testes : an estrogenic effect of di(n-butyl)phthalate and its relationship with testicular steroidogenesis2009
- Author(s)
  Alam, M.S., Ohsako, S., Tsunekawa, N.Kanai, Y., Tohyama, C., Kurohmaru, M.
- Organizer
  The 3^<rd> Congress of the Asian Association of Veterinary Anatomists
- Place of Presentation
  清州(韓国)
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] Di(n-butyl) phthalate (DBP) induces spermatogenic cell apoptosis via estrogen receptor in prepubertal rat testes2009
- Author(s)
  Mohammad Shah Alam,大迫誠一郎,祝暁波,恒川直樹,金井克晃,九郎丸正道
- Organizer
  第147回日本獣医学会
- Place of Presentation
  宇都宮
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] Di(n-butyl)phthalate(DBP)induces spermatogenic cell apoptosis via estrogenreceptor in prepubertal rat testes2009
- Author(s)
  Alam, M.S., Ohsako, S., Tsunekawa, N.Kanai, Y., Kurohmaru, M.
- Organizer
  第147回日本獣医学会学術集会
- Place of Presentation
  宇都宮
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] Di(n-butyl) phthalate(DBP) induces spermatogenic cell apoptosis via estrogen receptor in prepubertal rat testes2009
- Author(s)
  Mohammad Shah Alam,大迫誠一郎,祝暁波,恒川直樹,金井克晃,九郎丸正道
- Organizer
  第147回日本獣医学会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] Induction of spermatogeni cell apoptosis in prepubertal rat testes : an estrogeniceffect of di(n-butyl) phthalate and its relationship with testicular steroidogenesis2009
- Author(s)
  Alam, M. S., Ohsako, S., Tsunekawa, N. K anai, Y., Tohyama, C., Kurohmaru, M.
- Organizer
  The 3^<rd. Congress of the Asian Association of Veterinary Anatomists
- Place of Presentation
  Korea
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis : a possible estrogenic effect of di(n-butyl) phthalate2009
- Author(s)
  Alam, M. S., Ohsako, S., Matsuwaki, T., Tsunekawa, N., Kanai, Y., Kurohmaru, M.
- Organizer
  21^<st> Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] Di-iso-butyl phthalate(DIBP)の精巣毒性における特異性の検討2008
- Author(s)
  祝暁波,大迫誠一郎,Mohammad Shah Alam,大迫誠一郎,恒川直樹,金井克晃,遠山千春,九郎丸正道
- Organizer
  第146回日本獣医学
- Place of Presentation
  宮崎
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20380153
[Presentation] マウス肝臓の後期発生におけるSox17のハプロ不全2008
- Author(s)
  三浦雄太郎, 上村麻実, 永田工, 原健士朗, 金井正美, 恒川直樹, 九郎丸正道, 金井克晃
- Organizer
  第15回肝細胞研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19380168
[Presentation] Di-iso-butyl phthalate(DIBP)の精巣毒性における特異性の検討2008
- Author(s)
  祝暁波,大迫誠一郎, Mohammad Shah Alam,恒川直樹,金井克晃,遠山千春,九郎丸正道
- Organizer
  第146回日本獣医学会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-20380153

1. HAYASHI Yoshihiro (90092303)

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KUROHMRU Masamichi 九郎丸 正道

Research Projects

Research Products

Co-Researchers

哺乳類の生殖腺の性的２型の維持と破綻の分子基盤の解明Ongoing

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季節繁殖動物における精原幹細胞ニッチシステムの解析Ongoing

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胆嚢・胆管の形態形成・再生能と先天性疾患の分子機構の解明Ongoing

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Analysis of the toxicological effects of phthalate esters on testes by administration, culture and transplantation methodsPrincipal Investigator

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雄性生殖幹細胞移植法及び精細管移植法を用いた生殖毒性試験法の確立Principal Investigator

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Morphological and molecular analyses on testiculture tissuer at hibernation periodPrincipal Investigator

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Review Section

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Principal Investigator

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KUROHMRU Masamichi 九郎丸正道

ビタミンA欠乏ハムスターを用いた精細管ステージ同期化実験系の確立とその機構解明Principal Investigator