UNO Tadayuki 宇野公之

… Alternative Names

宇野公之ウノタダユキ

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Researcher Number	00183020
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2017: 大阪大学, 薬学研究科, 教授 2011 – 2016: 大阪大学, 薬学研究科(研究院), 教授 2012: 大阪大学, 大学院・薬学研究科, 教授 2006 – 2011: 大阪大学, 薬学研究科, 教授 2010: Osaka University, 大学院・薬学研究科, 教授 … More 2003 – 2004: 熊本大学, 大学院・医学薬学研究部, 教授 1997 – 2002: 熊本大学, 薬学部, 教授 1996: 徳島大学, 薬学部, 助教授 1994: 徳島大学, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy Except Principal Investigator Physical pharmacy / General pharmacology / Control engineering/System engineering
Keywords	Principal Investigator 薬物代謝 / シトクロムP450 / 共鳴ラマン分光 / DNA / 一塩基多型 / Porphyrin / ポルフィリン / インターカレーション / Drug Metabolism / Resonance Raman Spectroscopy … More / Resonance Ramen Spectroscopy / 共鳴ラマンスペクトル / 光切断 / Induced CD Spectroscopy / Intercalation / 誘起CDスペクトル / RNA / 電気化学 / X線結晶構造解析 / ヘムタンパク質 / ヘム / アクリジン / Single Nucleotide Polymorphism / Cvtochrome P450 / Substrate Specificity / Binding Constant / Equilibrium Dialysis / Cytochrome P450 / 平衡透析 / 基質特異性 / 結合定数 / 平衡誘析 / Telomere / Photonuclease / テロメア / Heme Protein / Transcription Factor / Sensor Protein / Gas Molecules / シグナル伝達 / ガスセンサー / 転写因子 / センサータンパク質 / ガス分子 / Cleavage / アミノ基 / 塩基対 / シトクロムb / 切断 / グループ結合 / RNA2重らせん / ポリフィリン / スタッキング / DNA-RNAハイブリッド / グルーブ結合 / 薬剤反応性 / 酸化還元電位 / シトクロムＰ４５０ / pH依存性 / ガス結合性 / ニトロフォリン / 一酸化窒素 / ゲルシフト / 酸化反応 / 遺伝子切断 / 融合タンパク質 / ホメオドメイン / 薬物結合 / 酸素結合 / 部位特異的変異 / へリックスバンドル / シトクロムb562 / 酸化活性 / 塩基配列 / ヘミン … More Except Principal Investigator 結晶構造解析 / 作用機序解明 / 創薬 / ドッキングシミュレーション / 構造解析 / 抗結核薬 / 結核菌 / cytochrome b562 / recombinant human serum albumin / human serum albumin / S-nitrosylation / α_1-acid glycoprotein / pyridoxalated hemoglobin polyoxyethylene conjugate / 血漿由来HSA / 組換え型HSA / 血流阻害抑制作用 / αー1酸性糖タンパク / ポリオキシエチレン・重合ヘモグロビン(PHP) / 人口酸素運搬体 / シトクロムb562変異体 / ミオグロビン変異体 / 変異アルブミン / 炎症 / 白血球走化性抑制作用 / 微細循環改善作用 / 細隙通過促進作用 / α-1酸性糖タンパク / 配位子結合性 / ミオグロビン / Cys残基 / 酸化アルブミン / シトクロムb562 / 組換え型アルブミン / ヒト血清アルブミン / S-ニトロソ化 / α_1酸性糖蛋白 / ピリドキシル化ポリオキシエチレンヘモグロビン重合体 / 確率論 / 確率 / 機械学習 / 薬学 / 情報通信工学 / 制御工学 Less

Origination of antibiotic drugs for tuberculosis based on the structural analyses of novel target proteins
- Principal Investigator
  
  YAMASHITA Taku
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Mukogawa Women's University
Control systems that utilize interaction with environmental fluctuation
- Principal Investigator
  
  Kashima Kenji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Control engineering/System engineering
- Research Institution
  Kyoto University
Construction of a High-throughput Evaluating System for Drug Metabolism of CYP with Gold ElectrodePrincipal Investigator
- Principal Investigator
  
  UNO TADAYUKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
Chain Reaction of Drug Metabolism -A Comprehensive Study on the Cooperative and Competitive Drug Metabolism by CYP IsoformsPrincipal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
CYP on a Chip ~Rapid Evaluation of CYP Drug Metabolism with Silver Chip Electrode~Principal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
A Comprehensive Study on the Drug-Drug Interactions in Drug Metabolizing Enzyme CYPPrincipal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
昆虫の吸血戦略:ムシの唾はどのように血管を拡げるか?Principal Investigator
- Principal Investigator
  
  宇野公之
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
A Comprehensive Study on the Effect of Human Genetic Polymorphism on the Drug Metabolizing, Properties of CYPPrincipal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
ホメオヘムプロテインPrincipal Investigator
- Principal Investigator
  
  宇野公之
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
A Comprehensive Study on the Effects of Genetic Polymorphism on the Drug Metabolizing Activity of Human CYPPrincipal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
薬物代謝酵素CYP2C9の酸化活性とSNPとの対応関係Principal Investigator
- Principal Investigator
  
  宇野公之
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Studies on the Signal Transduction Mechanism by Gas Sensor ProteinsPrincipal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of Porphyrin as a Molecular Cutter of GenesPrincipal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
神はすべての可能性をシャッフルしたもうたか?Principal Investigator
- Principal Investigator
  
  宇野公之
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
A STUDY ON DNA CLEAVAGE MECHANISM BY WATER-SOLUBLE PORPHYRINSPrincipal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Physical pharmacy
- Research Institution
  KUMAMOTO UNIVERSITY
Application of plasma proteins as blood substitutes
- Principal Investigator
  
  NISHI Katsuhide
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
INTERACTIONS BETWEEN NUCLEIC ACIDS AND METALLOPORPHYRINSPrincipal Investigator
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  KUMAMOTO UNIVERSITY
  The University of Tokushima
核酸の塩基配列を認識するヘム錯体の合成とその性質Principal Investigator
- Principal Investigator
  
  宇野公之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima

All 2014 2013 2012 2011 2010 2009 2008 2007 2004 2003 Other

All Journal Article Presentation Book

[Book] 共鳴ラマン分光法によるヘムタンパク質の活性部位構造の解明薬学分析科学の最前線(日本薬学会物理系薬学部会・分析化学担当教員会議編)東京2009
- Author(s)
  宇野公之
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-20390011
[Journal Article] Effect of Cytochrome P450 2C19 and 2C9 Amino Acid Residues 72 and 241 on Metabolism of Tricyclic Antidepressant Drugs2014
- Author(s)
  Tamer Zekry Attia, Taku Yamashita, Mohamed Abdelkhalek Hammad, Akinori Hayasaki, Takumi Sato, Masayoshi Miyamoto, Yuki Yasuhara, Takashi Nakamura, Yusuke Kagawa, Hirofumi Tsujino, Mahmoud Ahmed Omar, Osama Hassan Abdelmageed, Sayed Mohamed Derayea, Tadayuki Uno
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 62 Issue: 2 Pages: 176-181
- DOI
  10.1248/cpb.c13-00800
- NAID
  130003390760
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390011, KAKENHI-PROJECT-23790045
[Journal Article] Comparison of Cytochrome P450 Mediated Metabolism of Three Central Nervous System Acting Drugs2012
- Author(s)
  Tamer Zekry Attia, Taku Yamashita, Masayoshi Miyamoto, Atsushi Koizumi, Yuki Yasuhara, Jun-ichi Node, Yumi Erikawa, Yumi Komiyama, Chiaki Horii, Mayu Yamada, Mahmoud Ahmad Omar, Osama Hassan Abdelmageed, Sayed Mohamed Derayea, Tadayuki Uno
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 12 Pages: 1544-1549
- DOI
  10.1248/cpb.c12-00719
- NAID
  130001852550
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390011, KAKENHI-PROJECT-23790045
[Journal Article] Comparison of Cytochrome P450 Mediated Metabolism of Three CNS Acting Drugs2012
- Author(s)
  Tamer Zekry Attia, Taku Yamashita, Masayoshi Miyamoto, Atsushi Koizumi, Yuki Yasuhara, Jun-ichi Node, Yumi Erikawa, Yumi Komiyama, Chiaki Horii, Mayu Yamada, Mahmoud Ahmad Omar, OsamaHassan Abdelmageed, Sayed Mohamed Derayea, and Tadayuki Uno
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 60 Pages: 1544-1549
- URL
  https://www.jstage.jst.go.jp/article/cpb/60/12/60_c12-00719/_article
- Data Source
  KAKENHI-PROJECT-23659023
[Journal Article] Residues in the Distal Heme Pocket of Neuroglobin : Implications for the Multiple Ligand Binding Steps2004
- Author(s)
  Tadayuki Uno, Daisuke Ryu, Hiroko Tsutsumi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony J.Wilkinson, Hideaki Sato, Takashi Hayashi
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 5886-5893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Functional Evaluation of Heme Vinyl Groups in Myoglobin with Symmetric Protoheme Isomers2004
- Author(s)
  Tadayuki Uno
- Journal Title
  
  Biochemistry 43
  
  Pages: 13149-13155
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Residues in the Distal Heme Pocket of Neuroglobin : Implications for the Multiple Ligand Binding Steps2004
- Author(s)
  Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 5886-5893
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] The C-Helix in CooA Rolls upon CO Binding to Ferrous Heme2004
- Author(s)
  Taku Yamashita, Yohei Hoashi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 47320-47325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Roles of Heme Axial Ligands in the Regulation of CO Binding to CooA2004
- Author(s)
  Taku Yamashita, Yohei Hoashi, Kimiko Watanabe, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 21394-21400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Functional Evaluation of Heme Vinyl Groups in Myoglobin with Symmetric Protoheme Isomers2004
- Author(s)
  Yasuhiro Mie, Chiho Yamada, Georges P-J.Hareau, Saburo Neya, Tadayuki Uno, Noriaki Funasaki, Katsuhiko Nishiyama, Isao Taniguchi
- Journal Title
  
  Biochemistry 43
  
  Pages: 13149-13155
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] The C-Helix in CooA Rolls upon CO Binding to Ferrous Heme2004
- Author(s)
  Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 47320-47325
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Roles of Heme Axial Ligands in the Regulation of CO Binding to CooA2004
- Author(s)
  Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 21394-21400
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Inversion of Axial Coordination in Myoglobin to Create a "Proximal" Ligand Binding Pocket2003
- Author(s)
  Tadayuki Uno
- Journal Title
  
  Biochemistry 42
  
  Pages: 10191-10199
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Inversion of Axial Coordination in Myoglobin to Create a "Proximal" Ligand Binding Pocket2003
- Author(s)
  Tadayuki Uno, Rikiharu Sakamoto, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony J.Wilkinson
- Journal Title
  
  Biochemistry 42
  
  Pages: 10191-10199
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Presentation] 銀/金ナノ粒子を用いたCYP－薬物親和性に対する新規高感度評価系の構築2013
- Author(s)
  中村隆志、小宮山祐美、山下沢、宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  武蔵野大学
- Data Source
  KAKENHI-PROJECT-25670012
[Presentation] CYP3A4における薬物結合様式の分光学的解析2013
- Author(s)
  倉橋拓也, 小泉温史, 山下沢, 宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  西東京
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] 化合物ライブラリースクリーニングによるインドールアミン2,3-ジオキシゲナーゼ新規阻害剤の発見2013
- Author(s)
  志村明人　川崎崇弘、福永彩乃、山下沢、辻野博文、宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  武蔵野大学
- Data Source
  KAKENHI-PROJECT-25670012
[Presentation] Roles of Terminal Domains in the Ligand Binding Properties of Cytoglobin2013
- Author(s)
  花井舜平、辻野博文、山下沢、宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  武蔵野大学
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Spectroscopic Characterization of Drug Binding to Cytochrome P450 3A42013
- Author(s)
  倉橋拓也、小泉温史、山下沢、宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  武蔵野大学
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] サイトグロビンの配位子結合性に対する両末端ドメインの影響2013
- Author(s)
  花井舜平, 辻野博文, 宇野公之
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  西東京
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Construction of novel sensitive system to evaluate drug affinities for CYPs with Ag/Au nanoparticles2013
- Author(s)
  Takashi NAKAMURA, Yumi KOMIYAMA, Hirofumi TSUJINO, Taku YAMASHITA, and Tadayuki UNO
- Organizer
  第23回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  西東京
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23659023
[Presentation] Molecular Analysis of Human Drug Metabolizing Enzyme, Cytochrome P4502013
- Author(s)
  Tadayuki Uno
- Organizer
  The Eighth Indochina Conference on Pharmaceutical Sciences
- Place of Presentation
  Ho Chi Minh City, Vietnam
- Year and Date
  2013-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Molecular Analysis of Human Drug Metabolizing Enzyme, Cytochrome P4502013
- Author(s)
  Tadayuki Uno
- Organizer
  The Eighth Indochina Conference on Pharmaceutical Sciences
- Place of Presentation
  Lotte Legend Hotel, Vietnam
- Invited
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Comparison of Cytochrome P450 Mediated Metabolism of Three CNS Acting Drugs2012
- Author(s)
  Taku Yamashita, Tamer Zekry Attia, Masayoshi Miyamoto, Atsushi Koizumi, Yuki Yasuhara, Jun-ichi Node, Yumi Erikawa, Yumi Komiyama, Chiaki Horii, Mayu Yamada, Mahmoud Ahmad Omar, Osama Hassan Abdelmageed, Sayed Mohamed Derayea, and Tadayuki Uno
- Organizer
  50th Anniversary Symposium on Cytochrome P450 in Fukuoka
- Place of Presentation
  Fukuoka
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-23659023
[Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on Drug Metabolism in Human CYP2C92012
- Author(s)
  Tadayuki Uno, Yumi Erikawa, Masayoshi Miyamoto, Yuki Yasuhara, Taku Yamashita, Hiroshi Aoyama
- Organizer
  Seventh International Conference on Porphyrins and Phthalocyanines
- Place of Presentation
  Jeju, Korea
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effects of SNPs on the metabolism of Amitriptyline in CYP2D62012
- Author(s)
  宇野公之, 堀井千明, 山田麻由, 上村真司, 青山浩, 山下沢
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on the Interaction of Human CYP reductase with CYP2C19 and Its Drug Metabolizing Properties2012
- Author(s)
  宮本正芳, 飯賀由実子, 松本麻希, 安原由樹, 青山浩, 山下沢, 宇野公之
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] The role of lipid membrane in the course of drug metabolism by cytochrome P4502012
- Author(s)
  宇野公之, 安原由樹, 宮本正芳, 山田麻由, 山下沢, 青山浩
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effect of Single Nucleotide Polymorphisms(SNPs) on the Activation of Procarcinogens in Human CYP1A22012
- Author(s)
  Tadayuki Uno, Jun-ichi Node, Sakiko Morita, Akihide Tsujimoto, Taku Yamashita, Hiroshi Aoyama
- Organizer
  Seventh International Conference on Porphyrins and Phthalocyanines
- Place of Presentation
  Jeju, Korea
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Activation of Procarcinogens in Human CYP1A22012
- Author(s)
  Jun-ichi Node（Tadayuki Uno）
- Organizer
  Seventh International Conference on Porphyrins and Phthalocyanines
- Place of Presentation
  Jeju, Korea
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Three Cytochrome P450s Responsible for the Metabolism of Amitriptyline and Imipramine2011
- Author(s)
  Tadayuki Uno, Mayu Yamada, Shinji Uemura, Sakiko Morita, Maki Matsumoto, Hiroshi Aoyama, Taku Yamashita
- Organizer
  15th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Binding and Metabolizing Properties of Human CYP2C192011
- Author(s)
  Tadayuki Uno, Masayoshi Miyamoto, Yumiko Iiga, Maki Matsumoto, Hiroshi Aoyama, Taku Yamashita
- Organizer
  15th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Construction of Ag nanoparticle system sensitive to the active site structure in heme oroteins2011
- Author(s)
  宇野公之、小宮山祐美、金森美果、山下沢、青山浩
- Organizer
  第21回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2011-05-30
- Data Source
  KAKENHI-PROJECT-23659023
[Presentation] SNP variants reveal the crucial region for drug recognition in human CYP2C19 The International Chemical Congress of Pacific Basin Societies2010
- Author(s)
  Maki Matsumoto, Yumiko Iiga, Sayed M.S. Ali, Ryuichi Sasaki, Taku Yamashita, Hiroshi Aoyama, Tadayuki Uno
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Drug Binding and Metabolizing Properties of Human Cytochrome P450 1A22010
- Author(s)
  宇野公之, 森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩
- Organizer
  Sixth International Conference on Porphyrins and Phthalocyanines (ICPP-6)
- Place of Presentation
  Santa Ana Pueblo, New Mexico, USA
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Expression and purification of NADPH-cytochrome P450 oxidoreductase2010
- Author(s)
  宇野公之, 宮本正芳, 戸山亮, 松本麻希, 金森美果, 山田麻由, 山下沢, 青山浩
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Effect of Single Nucleotide Polymorphisms on the Drug Metabolizing Properties of Human Cytochrome P450 1A22010
- Author(s)
  宇野公之
- Organizer
  39th International Conference on Coordination Chemistry
- Place of Presentation
  Adelaide Convention Centre (Australia)
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Proton relay system in human CYP2C9 as revealed by site-directed mutagenesis The International Chemical Congress of Pacific Basin Societies2010
- Author(s)
  金森美果, 大河万顕, 香川雄輔, 山下沢, 青山浩, 宇野公之
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Drug Binding and Metabolizing Properties of Human Cytochrome P450 1A22010
- Author(s)
  宇野公之
- Organizer
  Sixth International Conference on Porphyrins and Phthalocyanines
- Place of Presentation
  Hyatt Regency Tamaya Resort & Spa (USA)
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Effect of Single Nucleotide Polymorphisms on the Drug Metabolizing Properties of Human Cytochrome P450 1A22010
- Author(s)
  Tadayuki Uno, Sakiko Morita, Akihide Tsujimoto, Shinji Murata, Masafumi Egawa, Taku Tamashita, Hiroshi Aoyama
- Organizer
  39th International Conference on Coordination Chemistry (ICCC39) Adelaide
- Place of Presentation
  South Australia Australia
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] 個別化医療に向けた医薬品の適正使用2010
- Author(s)
  宇野公之
- Organizer
  第42回大阪大学中之島講座
- Place of Presentation
  大阪
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Resonance Raman spectroscopy reveals distinct drug orientation in human CYP2D62010
- Author(s)
  宇野公之, 山田麻由, 上村真司, 柳田詩織, 森田早紀子, 松本麻希, 青山浩, 山下沢
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Metabolizing Properties of Human CYP2C192010
- Author(s)
  Tadayuki Uno, Maki Matsumoto, Yumiko Iiga, Sayed M.S. Ali, Ryuichi Sasaki, Taku Yamashita, Hiroshi Aoyama
- Organizer
  The 5th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  Suita, Osaka, Japan
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] 共鳴ラマン分光法によるヘムタンパク質の構造・機能解析2010
- Author(s)
  宇野公之
- Organizer
  岡山大&理研ジョイントシンポジウム最先端計測技術のトレンド2010
- Place of Presentation
  岡山
- Year and Date
  2010-06-28
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Amino acid residues involved in the proton relay system in human CYP2C92010
- Author(s)
  宇野公之, 金森美果, 大河万顕, 香川雄輔, 山下沢, 青山浩
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Drug Binding and Metabolizing Properties of Human CYP2D62009
- Author(s)
  Tadayuki Uno, Shinji Uemura, Shiori Yanagita, Taku Yamashita, Hiroshi Aoyama
- Organizer
  14th International Conference on Biological Inorganic Chemistry (ICBIC XIV)
- Place of Presentation
  Nagoya, Aichi, Japan
- Year and Date
  2009-07-26
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の薬物結合および代謝能2009
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  吹田
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYPlA2の代謝活性と-塩基多型との相関2009
- Author(s)
  宇野公之、森田早紀子、辻本景英、江川真文、山下沢、青山浩
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  大阪大学銀杏会館
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の薬物結合性及び代謝活性2009
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
- Organizer
  日本薬学会129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP1A2の代謝活性と一塩基多型との相関2009
- Author(s)
  宇野公之, 森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  吹田
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2C19の薬物結合および代謝能における一塩基多型の影響2009
- Author(s)
  宇野公之, 松本麻希, 飯賀由実子, Sayed M.S. Ali, 佐々木隆一, 山下沢, 青山浩
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  吹田
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒト薬物代謝酵素CYP1A2の一塩基多型と薬物代謝活性との相関2009
- Author(s)
  森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩, 宇野公之
- Organizer
  第59回日本薬学会近畿支部大会東
- Place of Presentation
  大阪
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の発現と薬物代謝活性2008
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 青山浩
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒト薬物代謝酵素CYP2C9の一塩基多型と薬物代謝活性の相関2008
- Author(s)
  宇野公之, 大河万顕, 香川雄輔, 渡辺亮介, 繁富輝明, 山下沢, 青山浩
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒト薬物代謝酵素CYP3A4の基質認識と薬物代謝反応機構2008
- Author(s)
  宇野公之, 服部芳明, 野中朋子, Rajamanickam Vijayalakshmi, 鶴田諒介, 山下沢, 青山浩
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Binding and Metabolizing Properties of Human CYP2C192008
- Author(s)
  宇野公之, 飯賀由実子, Sayed Ali, 佐々木隆一, 富杉佳計, 青山浩
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の発現と薬物代謝活性2008
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の発現と薬物代謝活性2008
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 青山浩
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒト薬物代謝酵素CYP2C9の一塩基多型と薬物代謝活性との相関2007
- Author(s)
  宇野公之、香川雄輔、渡辺亮介、繁富輝明、植田哲嗣、富杉佳計、石川吉伸、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都テルサ
- Year and Date
  2007-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390013
[Presentation] Correlations between SNPs and Drug Petabolizing Properties of Human CYPs2007
- Author(s)
  Tadayuki, Uno, Yusuke, Kagawa, Ryosuke, Watanabe, Teruaki, Shigetomi, Noritsugu, Ueda, Yoshikazu, Tomisugi, Yoshinobu, Ishikawa, Hatsuo, Maeda
- Organizer
  17th Symposium on the Reactions of Metals
- Place of Presentation
  Kyoto Tersa
- Year and Date
  2007-06-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390013
[Presentation] CYP薬物代謝の分析科学
- Author(s)
  宇野公之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25670012
[Presentation] CYP2C9と2C19の薬物識別に関わる72位及び241位残基の役割
- Author(s)
  早崎瑛紀、佐藤匠、宮本正芳、安原由樹、Tamer Z. Attia、Mohamed A. Hammad、辻野博文、山下沢、宇野公之
- Organizer
  第24回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都薬科大学
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-25670012

1. ISHIKAWA Yoshinobu (00305004)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. YAMASHITA Taku (70398246)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. TOMISUGI Yoshikazu (80322311)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. AOYAMA Hiroshi (60291910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
5. 辻野博文 (10707144)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 宮本正芳

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. Kashima Kenji (60401551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHTA Yoshito (30160518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OHKI Kentaro (40639233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MASAYUKI Masayuki (80200301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOMINAMI DAICHI (00709678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NISHI Katsuhide (00040220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OTAGIRI Masaki (80120145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MAEDA Hiroshi (90004613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKESHITA Kohei (80346808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ARAI Masayoshi (80311231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 前田初男 (00229311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. SASAMOTO Kazumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 野出純一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 小泉温史

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 山田麻由

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 小宮山祐美

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 佐藤匠

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 志村明人

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 中村隆志

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 川口亮太

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 早崎瑛紀

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 安原由樹

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. 長尾龍

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 成清由梨

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 奥野真未

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 細川由香里

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 堀井千明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

UNO Tadayuki 宇野 公之

宇野 公之 ウノ タダユキ

Research Projects

Research Products

Co-Researchers

Origination of antibiotic drugs for tuberculosis based on the structural analyses of novel target proteins

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Control systems that utilize interaction with environmental fluctuation

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Construction of a High-throughput Evaluating System for Drug Metabolism of CYP with Gold ElectrodePrincipal Investigator

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Chain Reaction of Drug Metabolism -A Comprehensive Study on the Cooperative and Competitive Drug Metabolism by CYP IsoformsPrincipal Investigator

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CYP on a Chip ~Rapid Evaluation of CYP Drug Metabolism with Silver Chip Electrode~Principal Investigator

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A Comprehensive Study on the Drug-Drug Interactions in Drug Metabolizing Enzyme CYPPrincipal Investigator

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昆虫の吸血戦略:ムシの唾はどのように血管を拡げるか?Principal Investigator

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A Comprehensive Study on the Effect of Human Genetic Polymorphism on the Drug Metabolizing, Properties of CYPPrincipal Investigator

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ホメオヘムプロテインPrincipal Investigator

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A Comprehensive Study on the Effects of Genetic Polymorphism on the Drug Metabolizing Activity of Human CYPPrincipal Investigator

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薬物代謝酵素CYP2C9の酸化活性とSNPとの対応関係Principal Investigator

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Studies on the Signal Transduction Mechanism by Gas Sensor ProteinsPrincipal Investigator

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Development of Porphyrin as a Molecular Cutter of GenesPrincipal Investigator

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UNO Tadayuki 宇野公之

宇野公之ウノタダユキ