ISHIKAWA Yoshinobu 石川吉伸

Researcher Number	00305004
Other IDs
Affiliation (Current)	2018 : 静岡県立大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2018 : 静岡県立大学, 薬学部, 准教授 2016 : 静岡県立大学, 薬学研究院, 准教授 2008 – 2014 : University of Shizuoka, 薬学部, 准教授 2007 : Kumamoto University, 大学院・医学薬学研究部, 講師 2006 : 熊本大学, 医学薬学研究部, 講師 2003 – 2004 : 熊本大学, 大学院・医学薬学研究部, 講師 1999 – 2002 : 熊本大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / 医薬分子機能学 / Physical pharmacy Except Principal Investigator Physical pharmacy / Physical pharmacy / Natural medicines / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator ポルフィリン / 四重鎖 / テロメラーゼ / テロメア / 阻害剤 / 有機化学 / 抗ガン剤 / DNA / 核酸 / 生物物理 … More Except Principal Investigator DNA / Resonance Ramen Spectroscopy / ポルフィリン / 光切断 / Porphyrin / 共鳴ラマンスペクトル / Intercalation / 免疫チェックポイント / Sensor Protein / Transcription Factor / 共鳴ラマン分光 / 平衡誘析 / Heme Protein / シトクロムP450 / Gas Molecules / 結合定数 / Cytochrome P450 / インターカレーション / 生物活性試験 / Drug Metabolism / Telomere / 基質特異性 / 薬物代謝 / 薬用植物 / アクリジン / シトクロムb / 化学構造解析 / 転写因子 / ガス分子 / 国際情報交換 / Binding Constant / シグナル伝達 / センサータンパク質 / 伝統医学 / Cleavage / 切断 / 平衡透析 / Photonuclease / モンゴル国 / アミノ基 / ヘム / Substrate Specificity / テロメア / 塩基対 / 薬効成分 / Resonance Raman Spectroscopy / Induced CD Spectroscopy / 昆虫 / 誘起CDスペクトル / ガスセンサー / Equilibrium Dialysis / ヘムタンパク質 Less

In silicoによるPD-1/PD-L1阻害活性を持つ低分子化合物の同定Ongoing
- Principal Investigator
  
  芦澤忠
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shizuoka Cancer Center Research Institute
ハロゲン結合を基盤とするウレアーゼ阻害剤の開発Principal InvestigatorOngoing
- Principal Investigator
  
  石川吉伸
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Bioactive compounds from Mongolian traditional medicinal plants and their effects evaluations to living organisms using insect
- Principal Investigator
  
  MURATA Toshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Natural medicines
- Research Institution
  Tohoku Medical and Pharmaceutical University
SBDD targeting metalloenzyme RNA polymeraze of influenza virusPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA YOSHINOBU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
Synthesis and analysis of telomere quadruplex DNA-binding porphyrins based on an electrostatic interaction modelPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Yoshinobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
Predicition and verification for the structures and thermodynamic properties of telomeric DNA quadruplex/porphyrin complexesPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Yoshinobu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
  Kumamoto University
A Comprehensive Study on the Effects of Genetic Polymorphism on the Drug Metabolizing Activity of Human CYP
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
テロメアDNA四重鎖構造を安定化させテロメラーゼを阻害するポルフィリンの開発Principal Investigator
- Principal Investigator
  
  石川吉伸
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Studies on the Signal Transduction Mechanism by Gas Sensor Proteins
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of Porphyrin as a Molecular Cutter of Genes
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
テロメア四重鎖DNAに作用する芳香族カチオン性ポルフィリンの開発Principal Investigator
- Principal Investigator
  
  石川吉伸
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
A STUDY ON DNA CLEAVAGE MECHANISM BY WATER-SOLUBLE PORPHYRINS
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Physical pharmacy
- Research Institution
  KUMAMOTO UNIVERSITY

[Book] in silico創薬におけるスクリーニングの高速化・高精度化技術2018
- Author(s)
  石川吉伸他計80名
- Total Pages
  540
- Publisher
  技術情報協会
- ISBN
  9784861046889
- Data Source
  KAKENHI-PROJECT-16K08199
[Journal Article] Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).2017
- Author(s)
  Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno S, Tanaka K, Hashimoto H.
- Journal Title
  
  J Biol Chem
  
  Volume : 292 Pages : 17658-17667
- DOI
  10.1074/jbc.m117.804237
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08199, KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-17K07316, KAKENHI-PUBLICLY-16H01296, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-15H04368, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840
[Journal Article] Mechanistic Insight into Weak-Base-Catalyzed Generation of Carbon Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation at Room Temperature without Use of External Carbon Monoxide Gas2017
- Author(s)
  Konishi Hideyuki、Matsubara Mika、Mori Keisuke、Tokiwa Takaki、Arulmozhiraja Sundaram、Yamamoto Yuta、Ishikawa Yoshinobu、Hashimoto Hiroshi、Shigeta Yasuteru、Tokiwa Hiroaki、Manabe Kei
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume : 359 Pages : 3592-3601
- DOI
  10.1002/adsc.201700751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KT0010, KAKENHI-PROJECT-16K08199, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-15H04634, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-15K18834
[Journal Article] Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton2017
- Author(s)
  Nagasaka Y, Shintaku S, Matsumura K, Masuda A, Asakawa T, Inai M, Egi M, Hamashima Y, Ishikawa Y, Kan T.
- Journal Title
  
  Org. Lett.
  
  Volume : 19 Pages : 3839-3842
- DOI
  10.1021/acs.orglett.7b01718
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08199, KAKENHI-PROJECT-17K15424, KAKENHI-PUBLICLY-16H01160, KAKENHI-PROJECT-17H03973
[Journal Article] Crystal structure of 7-iodo-4-oxo-4H-chromene-3-carbaldehyde2016
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst. sec. E.
  
  Volume : E72 Pages : 1724-1727
- DOI
  10.1107/s2056989016016972
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08199
[Journal Article] Abietane-type diterpenoids from the roots of Caryopteris mongolica and their cholinesterase inhibitory activities2016
- Author(s)
  Toshihiro Murata, Yoshinobu Ishikawa, Erdenebileg Saruul, Erdenechimeg Selenge, Kenroh Sasaki, Kaoru Umehara, Fumihiko Yoshizaki, Javzan Batkhuu
- Journal Title
  
  Phytochemistry
  
  Volume : 130 Pages : 152-158
- DOI
  10.1016/j.phytochem.2016.05.011
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860068, KAKENHI-PROJECT-16K08199
[Journal Article] Structural basis of new allosteric inhibition in kinesin spindle protein Eg5.2015
- Author(s)
  Yokoyama H, Sawada J, Katoh S, Matsuno K, Ogo N, Ishikawa Y, Hashimoto H, Fujii S, Asai A.
- Journal Title
  
  ASC Chem. Biol.
  
  Volume : 10 Pages : 1128-1136
- DOI
  10.1021/cb500939x
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141, KAKENHI-PUBLICLY-25121728, KAKENHI-PROJECT-25291017, KAKENHI-PROJECT-26440034, KAKENHI-PROJECT-26460150
[Journal Article] 7-Chloro-4-oxo-4H-chromene-3- carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814014925
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Chloro-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814007119
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Computational Prediction of Diastereomeric Separation Behavior of Fluorescent o-Phthalaldehyde Derivatives of Amino Acids.2014
- Author(s)
  Todoroki K, Nakano T, Watanabe H, Min JZ, Inoue K, Ishikawa Y, Toyo’oka T.
- Journal Title
  
  Anal. Sci.
  
  Volume : 30 Pages : 865-870
- Acknowledgement Compliant / Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-3,4,5-Trimethoxy-N’-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide2014
- Author(s)
  Ishikawa Y., Watanabe K.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814005753
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Iodo-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814012471
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Crystal structure of (3,5-dibromo- 2-hydroxyphenyl){1-[(naphthalen-1-yl)- carbonyl]-1H-pyrazol-4-yl}methanone2014
- Author(s)
  Ishikawa Y. Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814018601
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Fluoro-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814008502
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Diethyl 7,7'-dichloro-4-oxo-4H-[1,4'-biquinoline]-3,3'-dicarboxylate2014
- Author(s)
  Ishikawa Y., Sugisawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814010320
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Chloro-7-methyl-4-oxo-4H-chromene- 3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814014226
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Chloro-7-fluoro-4-oxo-4H-chromene- 3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814014706
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-4-Methoxy-N00-[(6-methyl-4-oxo-4Hchromen- 3-yl)methylidene]benzohydrazide monohydrate2014
- Author(s)
  Ishikawa Y., Watanabe K.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814013713
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Crystal structure of 7-bromo-4-oxo-4Hchromene- 3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814018108
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Ethyl 8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate2014
- Author(s)
  Ishikawa Y., Yoshida N.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814011854
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-3,4,5-Trimethoxy-N00-[(6-methoxy-4- oxo-4H-chromen-3-yl)methylidene] benzohydrazide monohydrate2014
- Author(s)
  Ishikawa Y., Watanabe K.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814014937
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 8-Fluoro-4-oxo-4H-chromene-3- carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814013208
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 3-Acetyl-2-fluoro-6H-benzo[c]chromen-6-one2014
- Author(s)
  Ishikawa Y., Suzuki T., Yoshida N.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814005959
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 8-Chloro-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814012483
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6,8-Diiodo-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814006904
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6,8-Dibromo-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814005327
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E )-4-Methyl-N-[(4-oxo-4H-chromen-3-yl)methylidene] benzohydrazide2014
- Author(s)
  Ishikawa Y., Watanabe K.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814008113
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Bromo-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s160053681400796x
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Chloro-8-nitro-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E70
- DOI
  10.1107/s1600536814007788
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 3-[(E)-(Benzyliminiumyl)methyl]-6,8-dichloro-2H-chromen-4-olate2013
- Author(s)
  Ishikawa Y., Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E69
- DOI
  10.1107/s1600536813018072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Ethyl (Z)-4-(4-ethoxy-1-hydroxy-3,4-dioxobut-1-en-1-yl)-[1,1-biphenyl]-3-carboxylate2013
- Author(s)
  Ishikawa Y., Ugai A.
- Journal Title
  
  Acta Cryst.
  
  Volume : E69
- DOI
  10.1107/s1600536813018503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] A Script for Automated 3-Dimentional Structure Generation and Conformer Search from 2-Dimentional Chemical Drawing2013
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Bioinformation
  
  Volume : 9 Pages : 988-992
- DOI
  10.6026/97320630009988
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-6,8-Dichloro-3-{[(naphthalen-1-ylmethyl)iminiumyl]methyl}-2H-chromen-4-olate2013
- Author(s)
  Ishikawa Y., Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E69
- DOI
  10.1107/s1600536813018084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 2-Hydroxyisoquinoline-1,3(2H,4H)-dione2013
- Author(s)
  Ishikawa Y., Matsuo S.
- Journal Title
  
  Acta Cryst.
  
  Volume : E69
- DOI
  10.1107/s1600536813019843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 2-(Benzyloxy)isoquinoline-1,3(2H,4H)-dione2013
- Author(s)
  Ishikawa Y., Matsuo S.
- Journal Title
  
  Acta Cryst.
  
  Volume : E69
- DOI
  10.1107/s1600536813019934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-3-{[([1,1-Biphenyl]-3-ylmethyl)iminiumyl]methyl}-6,8-dichloro-2H-chromen-4-olate2013
- Author(s)
  Ishikawa Y., Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E69
- DOI
  10.1107/s160053681302285x
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 4'-Acetyl-3''-carbamoyl-[1,1':3',1''-terphenyl]-2-carboxylic acid2013
- Author(s)
  Ishikawa Y., Yoshida N., Suzuki T.
- Journal Title
  
  Acta Cryst.
  
  Volume : E69
- DOI
  10.1107/s1600536813026482
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6,8-Dichloro-4-oxochromene-3-carbaldehyde2013
- Author(s)
  Ishikawa Y., Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume : E69
- DOI
  10.1107/s1600536813022228
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Regiocomplementary ycloaddi-tion Reactions of Boryl-and Silylben-zynes with 1,3-Dipoles: Selective Synthesis of Benzo-Fused Azole Derivatives2013
- Author(s)
  Akira Takagi, Takashi Ikawa, Alcira Takagi, Masahiko Goto, Yuya Aoyama, Yoshinobu Ishikawa, Yuji Itoh, Hiroaki Tokiwa, and Shuji Akai
- Journal Title
  
  J. Org. Chem.
  
  Volume : 78 Pages : 2965-2983
- DOI
  10.1021/jo302802b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10892, KAKENHI-PROJECT-22590039, KAKENHI-PROJECT-23790017, KAKENHI-PROJECT-24590141, KAKENHI-PROJECT-25460018, KAKENHI-PROJECT-25460157
[Journal Article] Novel candesartan derivatives as indole-amine-2,3-dioxygenase inhibitors2012
- Author(s)
  Matsuno K, Yamazaki H, Isaka Y, takai K, Unno Y, Ogo N, Ishikawa Y, Fujii S, Takikawa O, Asai A
- Journal Title
  
  Med. Chem. Commun.
  
  Volume : 3 Pages : 475-479
- DOI
  10.1039/c2md00278g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590353, KAKENHI-PROJECT-22590039, KAKENHI-PROJECT-24590141
[Journal Article] ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes : Synthesis of 2-Silylanilines2011
- Author(s)
  Ikawa T., Nishiyama T., Shigeta T., Mohri S., Morita S., Takayanagi S., Terauchi Y., Morikawa Y., Takagi A., Ishikawa Y., Fujii S., Kita Y. Akai S.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume : 50 Pages : 5674-5677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Binding mode prediction and inhibitor design of anti-influenza virus diketo acids targeting metalloenzyme RNA polymerase by molecular docking2011
- Author(s)
  Ishikawa Y. & Fujii S.
- Journal Title
  
  Bioinformation
  
  Volume : 6 Pages : 221-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Ortho-selective nucleophilic addition of primary amines to silylbenzynes : Synthesis of 2-silylanilines2011
- Author(s)
  Y . Kita et al.
- Journal Title
  
  Angew.Chem., Int.Ed.
  
  Volume : 50 Pages : 5674-5677
- DOI
  10.1002/anie.201100360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249002, KAKENHI-PROJECT-21590118, KAKENHI-PROJECT-23790017
[Journal Article] 1,1',1',1'-[Porphyrin-5,10,15,20-tetrayltetrakis(3,1-phenylenemethylene)]tetraquinolinium Tetrabromide2010
- Author(s)
  Ishikawa Y., Yamashita T., Fujii S., Uno T.
- Journal Title
  
  Molbank
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] 1, 1', 1'', 1'''-[Porphyrin-5, 10, 15, 20-tetrayltetrakis(3, 1-phenylenemethylene)] tetraquinolinium Tetrabromide2010
- Author(s)
  Ishikawa Y., Yamashita T., Fujii S., Uno T.
- Journal Title
  
  Molbank
  
  Volume : 704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Zinc(II)-5, 10, 15, 20-tetrakis(a-pyridino-m-tolyl)porphyrin Tetrabromide2009
- Author(s)
  Ishikawa Y., Yamashita T., Fujii S., Uno T.
- Journal Title
  
  Molbank
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Zinc(II)-5, 10, 15, 20-tetrakis(a-pyridino-m-tolyl) p orphyrin Tetrabromide2009
- Author(s)
  Ishikawa Y., Yamashita T., Fujii S., Uno T.
- Journal Title
  
  Molbank
  
  Volume : 637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Binding of Cationic Bis-porphyrins Linked with p-or m- Xylylenediamine and Their Zinc(II)Complexes to Duplex DNA.2008
- Author(s)
  Yoshinobu Ishikawa, Naoki Yamakawa, Tadayuki Uno.
- Journal Title
  
  Molecules 13
  
  Pages : 3117-3128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular docking study of binding of TMPyP4 to a bimolecular human telomeric G-quadruplex.2008
- Author(s)
  Yoshinobu Ishikawa, Satoshi Fujii.
- Journal Title
  
  Nucleic Acids Symp. Ser. 52
  
  Pages : 173-174
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular docking study of binding of TMPyP4 to a bimolecular human telomeric G-quadruplex2008
- Author(s)
  Ishikawa Y, Fujii S
- Journal Title
  
  Nucleic Acids Symp. Ser 52
  
  Pages : 173-174
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Binding of Cationic Bis-porphyrins Linked with p- or m- Xylylenediamine and Their Zinc(II) Complexes to Duplex DNA2008
- Author(s)
  Ishikawa Y, Yamakawa N, Uno T
- Journal Title
  
  Molecules 13
  
  Pages : 3117-3128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular Docking of porphyrins with cationic limbs on Intramolecular G-quadruplex2007
- Author(s)
  Ishikawa Y, Higashi E, Morioka H
- Journal Title
  
  Nucleic Acids Symp. Ser 51
  
  Pages : 247-248
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular Docking of porphyrins with cationic limbs on Intramolecular G-quadruplex2007
- Author(s)
  Ishikawa Y., Higashi E. and Morioka H.
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages : 247-248
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Synthetic Control of Interchromophoric Interaction in Cationic Bis-porphyrins toward Efficient DN.2007
- Author(s)
  Ishikawa Y., Yamakawa N. and Uno T.
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages : 5230-5238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Synthetic Control of Interchromophoric Interaction in Cationic Bis-porphyrins toward Efficient DNA Photocleavage with Singlet Oxygen Production in Aqueous Solution2007
- Author(s)
  Ishikawa Y, Yamakawa N and Uno T
- Journal Title
  
  Bioorg. Med. Chem 15
  
  Pages : 5230-5238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular modeling of Anti-parallel G-quadruplex DNA/TMPyP Complexes2006
- Author(s)
  Ishikawa Y, Tomisugi Y, Uno T
- Journal Title
  
  Nucleic Acids Symp. Ser 50
  
  Pages : 331-332
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular modeling of Anti-parallel G-quadruplex DNA/TMPyP Complexes2006
- Author(s)
  Yoshinobu Ishikawa, Yoshikazu Tomisugi, Tadayuki Uno
- Journal Title
  
  Nucleic Acids Symp.Ser. 50
  
  Pages : 331-332
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] The C-Helix in CooA Rolls upon CO Binding to Ferrous Heme2004
- Author(s)
  Taku Yamashita, Yohei Hoashi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages : 47320-47325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Roles of Heme Axial Ligands in the Regulation of CO Binding to CooA2004
- Author(s)
  Taku Yamashita, Yohei Hoashi, Kimiko Watanabe, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages : 21394-21400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Residues in the Distal Heme Pocket of Neuroglobin : Implications for the Multiple Ligand Binding Steps2004
- Author(s)
  Tadayuki Uno, Daisuke Ryu, Hiroko Tsutsumi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony J.Wilkinson, Hideaki Sato, Takashi Hayashi
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages : 5886-5893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Inversion of Axial Coordination in Myoglobin to Create a "Proximal" Ligand Binding Pocket2003
- Author(s)
  Tadayuki Uno, Rikiharu Sakamoto, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony J.Wilkinson
- Journal Title
  
  Biochemistry 42
  
  Pages : 10191-10199
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Presentation] テンプレートスイッチに関わるZRANB3のAlkB homolog 2 PCNA-binding motif (APIM)とPCNAの複合体の構造基盤と相互作用機構の解明2017
- Author(s)
  原幸大、内田雅之、田形梨紗、横山英志、石川吉伸、菱木麻美、橋本博
- Organizer
  第24回DNA複製・組換え・修復ワークショップ（岐阜）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 細胞分裂におけるMAD2L2-CAMP複合体の構造と相互作用機構の解明2017
- Author(s)
  原幸大、田原迫奨大、菱木麻美、石川吉伸、菅野新一郎、田中耕三、橋本博
- Organizer
  第63回日本薬学会東海支部総会・大会（岐阜）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] In silico screening系を用いたPD-1/PD-L1阻害活性を持つ低分子化合物の同定2017
- Author(s)
  秋山靖人、石川吉伸、安藤隆幸、井上謙吾
- Organizer
  日本がん分子標的治療学会第1回SNワークショップ
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] Crystallographic structure of Mad2L2-CAMP complex, a regulator of kinetochore-microtubule attachment2017
- Author(s)
  Kodai Hara, Shota Taharazako, Asami Hishiki, Yoshinobu Ishikawa, Shin-ichiro Kanno, Kozo Tanaka, Hiroshi Hashimoto
- Organizer
  SMC proteins 2017 “chromosomal organizers from bacteria to human”（Yamagata）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 染色体分配に関わるMAD2L2-CAMP複合体の構造基盤と相互作用機構の解明2017
- Author(s)
  原幸大、田原迫奨大、池田真教、藤田拡樹、三上嘉子、菊池壮太郎、菱木麻美、横山英志、石川吉伸、菅野新一郎、田中耕三、橋本博
- Organizer
  第35回染色体ワークショップ（愛知）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] PCNAとHLAペプチドの結晶学的研究2017
- Author(s)
  鈴木麻里子、原幸大、菱木麻美、石川吉伸、橋本博
- Organizer
  第63回日本薬学会東海支部総会・大会（岐阜）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 染色体分配に関わるMad2L2-CAMP複合体のX線結晶構造解析2016
- Author(s)
  田原迫奨大、原幸大、菱木麻美、石川吉伸、菅野新一郎、田中耕三、橋本博
- Organizer
  日本病院薬剤師東海ブロック　日本薬学会東海支部合同学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] テンプレートスイッチに関わるZranb3 PIPとPCNAの構造機能解析2016
- Author(s)
  内田雅之、原幸大、田形梨紗、菱木麻美、石川吉伸、横山英志、橋本博
- Organizer
  第62回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 紫外線高感受性症候群責任因子UVSSAのVHSドメインのX線結晶構造解析2016
- Author(s)
  松尾和香、橋本優子、原幸大、菱木麻美、石川吉伸、郭朝万、中沢由華、唐田清伸、荻明男、橋本博
- Organizer
  日本病院薬剤師東海ブロック　日本薬学会東海支部合同学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 紫外線高感受性症候群責任因子UVSSAのVHSドメインの構造解析2016
- Author(s)
  松尾和香、橋本優子、原幸大、菱木麻美、石川吉伸、郭朝万、中沢由華、唐田清伸、荻明男、橋本博
- Organizer
  日本結晶学会平成28年度年会
- Place of Presentation
  水戸
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 染色体分配に関わるMad2L2-CAMP複合体のX線結晶構造解析2016
- Author(s)
  田原迫奨大、原幸大、菱木麻美、石川吉伸、菅野新一郎、田中耕三、橋本博
- Organizer
  日本結晶学会平成28年度年会
- Place of Presentation
  水戸
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] オリゴペプチド結合タンパク質の構造解析2016
- Author(s)
  亀井七海、横山英志、小西佳史郎、原幸大、石川吉伸、松井郁夫、Patrick Forterre、橋本博
- Organizer
  第62回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] テンプレートスイッチに関わるZRANB3とPCNAの相互作用解析2016
- Author(s)
  内田雅之、原幸大、田形梨紗、菱木麻美、石川吉伸、横山英志、橋本博
- Organizer
  日本結晶学会平成28年度年会
- Place of Presentation
  水戸
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] Novel cysteine derivatives for the next generation anticancer agents acting on KSP2014
- Author(s)
  Naohisa Ogo, Jun-ichi Sawada, Yoshinobu Ishikawa, Kenji Matsuno, Akihiro Hashimoto, Akira Asai
- Organizer
  25th EORTC-NCI-AACR symposium Molecular targets and cancer therapeutics
- Place of Presentation
  バルセロナ
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 新規KSP阻害剤の創製 ‐システイン誘導体の合成と構造活性相関‐2014
- Author(s)
  小郷尚久、石川吉伸、松野研司、澤田潤一、橋本章弘、浅井章良
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 量子化学計算に基づくアミノ酸ジアステレオマーの光学分離メカニズムの考察2014
- Author(s)
  中野達基、轟木堅一郎、石川吉伸、閔俊哲、井之上浩一、豊岡利正
- Organizer
  第74回分析化学討論会
- Place of Presentation
  郡山
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 新規システイン誘導体のKSP阻害に基づく次世代抗がん剤探索研究2014
- Author(s)
  小郷尚久、澤田潤一、石川吉伸、松野研司、橋本章弘、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第9回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] ATP拮抗型キネシンEg5阻害剤の阻害様式における構造的基盤2014
- Author(s)
  横山英志、澤田潤一、加藤詩織、松野研司、小郷尚久、石川吉伸、橋本博、藤井敏、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第9回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 塩基によるギ酸エステルの分解反応の計算化学的解析2014
- Author(s)
  森敬介、小西英之、石川吉伸、橋本博、眞鍋敬
- Organizer
  日本薬学会東海支部大会
- Place of Presentation
  鈴鹿
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 理論化学計算に基づくアミノ酸ジアステレオマー誘導体の光学分離メカニズムの考察2013
- Author(s)
  中野達基、轟木堅一郎、石川吉伸、閔俊哲、井之上浩一、豊岡利正
- Organizer
  新アミノ酸分析研究会　第3回学術講演会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] ギ酸エステルの分解による一酸化炭素生成反応の計算化学的解析2013
- Author(s)
  森敬介、小西英之、石川吉伸、橋本博、眞鍋敬
- Organizer
  第44回中部化学関係学協会支部連合秋季大会
- Place of Presentation
  浜松市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] インフルエンザウィルスの含金属エンドヌクレアーゼを阻害するアリールジケト酸のSB&CADD2013
- Author(s)
  石川吉伸、鵜飼淳、鈴木孝史、石垣範行、尾崎公英、横山英志、藤井敏
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] インフルエンザウイルスのRNAポリメラーゼサブユニットPANの精製と単結晶化2012
- Author(s)
  石川吉伸、尾崎公英、横山英志、藤井敏
- Organizer
  第 22 回日本病院薬剤師会東海ブロック学術大会・平成24年度日本薬学会東海支部例会
- Place of Presentation
  岐阜市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] Structure-based Inhibitor Design of Diketo Acid Derivatives Targeting Influenza Virus Metalloenzyme RNA Polymerase2012
- Author(s)
  Yoshinobu Ishikawa, Atsushi Ugai, Seiji Miyazaki, Noriyuki Ishigaki, Kimihide Ozaki, Hideshi Yokoyama, Satoshi Fujii
- Organizer
  40th International Conference on Coordination Chemistry
- Place of Presentation
  Valencia, Spain
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] インフルエンザウイルスの金属酵素RNAポリメラーゼを標的とするin silico創薬2012
- Author(s)
  石川吉伸、鵜飼淳、鈴木孝史、石垣範行、尾崎公英、横山英志、藤井敏
- Organizer
  第 22 回日本病院薬剤師会東海ブロック学術大会・平成24年度日本薬学会東海支部例会
- Place of Presentation
  岐阜市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] インフルエンザウィルスの金属酵素RNAポリメラーゼを阻害するアリールジケト酸誘導体のSB&CADD2012
- Author(s)
  石川吉伸、鵜飼淳、鈴木孝史、石垣範行、尾崎公英、横山英志、藤井敏
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  船堀市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] Binding mode prediction and design of diketo acid derivatives inhibiting Influenza Viral Metalloenzyme RNA Polymerase2011
- Author(s)
  Yoshinobu Ishikawa and Satoshi Fujii
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] Binding mode prediction and design of diketo acid derivatives in hibiting Influenza Viral Metalloenzyme RNA Polymerase2011
- Author(s)
  Yoshinobu Ishikawa, Satoshi Fujii
- Organizer
  16th SCI-RSC Cambridge Medicinal Chemistry Symposium
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] Structure-based Drug Design of Diketo Acid Derivatives inhibiting Influenza Viral Metalloenzyme RNA Polymerase2010
- Author(s)
  Yoshinobu Ishikawa, Satoshi Fujii
- Organizer
  International Symposium of Medicinal Chemistry
- Place of Presentation
  Brussels, Belgium
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] インフルエンザウィルスの金属酵素RNAポリメラーゼに対するジケト酸誘導体の分子ドッキング2010
- Author(s)
  石川吉伸, 藤井敏
- Organizer
  日本薬学会第130年会(岡山)
- Place of Presentation
  岡山大学
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] インフルエンザウィルスの金属酵素RNAポリメラーゼに対するジケト酸誘導体の分子ドッキング2010
- Author(s)
  石川吉伸、藤井敏
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] Binding mode prediction and rational design of diketo acid derivatives targeting metalloenzyme RNA polymerase of influenza virus2010
- Author(s)
  Yoshinobu Ishikawa, Satoshi Fujii
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] インフルエンザウィルス由来金属酵素RNAポリメラーゼに対するジケト酸誘導体の分子ドッキングによる結合様式予測2009
- Author(s)
  石川吉伸, 藤井敏
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] カチオン性ポルフィリンTMPyP4の二分子グアニン四重鎖DNAへの分子ドッキング2009
- Author(s)
  石川吉伸, 藤井敏
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] インフルエンザウィルス由来金属酵素RNAポリメラーゼに対するジケト酸誘導体の分子ドッキングによる結合様式予測2009
- Author(s)
  石川吉伸、藤井敏
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] テロメア四重鎖DNAを標的とするカチオン性ポルフィリンの抗腫瘍細胞増殖能2009
- Author(s)
  石川吉伸
- Organizer
  静岡県立大学 2008USフォーラム
- Place of Presentation
  静岡県立大学
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] テロメア四重鎖DNAを標的とするカチオン性ポルフィリンの抗腫瘍細胞増殖能2009
- Author(s)
  石川吉伸
- Organizer
  静岡県立大学2008 USフォーラム
- Place of Presentation
  静岡
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] カチオン性ポルフィリンTMPyP4の二分子グアニン四重鎖DNAへの分子ドッキング2009
- Author(s)
  石川吉伸、藤井敏
- Organizer
  第129回日本薬学会年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Amino Acid Residues Responsible for the Stabilization of Hemoglobin Tetramer2008
- Author(s)
  宇野公之、瀧川総太郎、石丸武史、清田浩平、甲斐俊哉、石川吉伸、富杉佳計、青山浩
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] インドールアミン2,3- ジオキシゲナーゼ(IDO)のヘム周辺環境と触媒機構2008
- Author(s)
  宇野公之、英杏子、牛田真衣、松浦明美、中山智香子、石川吉伸、富杉佳計、青山浩
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヘモグロビン四量体の会合安定化に関わるアミノ酸残基2008
- Author(s)
  宇野公之、瀧川総太郎、石丸武史、清田浩平、甲斐俊哉、石川吉伸、富杉佳計、青山浩
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular docking study of binding of TMPyP4 to a bimolecular human telomeric G-quadruplex2008
- Author(s)
  石川吉伸、藤井敏
- Organizer
  第35回核酸化学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] The Heme Environment of Human Indoleamine 2,3-Dioxygenase2008
- Author(s)
  宇野公之、英杏子、牛田真衣、松浦明美、中山智香子、石川吉伸、富杉佳計、青山浩
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] カチオン性ポルフィリンTMPyP4の二分子グアニン四重鎖DNAへの分子ドッキングシミュレーション2008
- Author(s)
  石川吉伸、藤井敏
- Organizer
  第54回日本薬学会東海支部大会
- Place of Presentation
  名古屋
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C19における一塩基多型と代謝活性の相関2008
- Author(s)
  佐々木隆一、Sayed M. S. Ali、小山由希子、石川吉伸、富杉佳計、青山浩、宇野公之
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C9の薬物結合性及び選択性を決定する残基の評価2008
- Author(s)
  香川雄輔、佐々木隆一、渡辺亮介、石川吉伸、富杉佳計、青山浩、宇野公之
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C9の一塩基多型と薬物代謝活性との相関2007
- Author(s)
  宇野公之、香川雄輔、渡辺亮介、繁富輝明、植田哲嗣、富杉佳計、石川吉伸、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular Docking of porphyrins with cationic limbs on Intramolecular G-quadruplex2007
- Author(s)
  Ishikawa Y., Higashi E. and Morioka H.
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Interaction of cationic porphyrin TMPyP4 with quadruplex DNA: a molecular dynamics simulation study2007
- Author(s)
  Yoshinobu ishikawa
- Organizer
  13th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  ウィーン
- Year and Date
  2007-07-16
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP1A2の薬物結合性と代謝活性 ~一塩基多型が及ぼす影響~2007
- Author(s)
  宇野公之、辻本景英、江川真文、村田晋一、永井英次、石川吉伸、富杉佳計、前田初男
- Organizer
  日本薬学会127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP1A2の薬物結合性と代謝活性に対する一塩基多型の影響2007
- Author(s)
  宇野公之、辻本景英、江川真文、村田晋一、永井英次、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] NO運搬タンパク質ニトロフォリン4の配位子結合に対する酸性残基の役割2007
- Author(s)
  宇野公之、大場伸紘、森山友美子、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] NO運搬タンパク質ニトロフォリン4(NP4)の外来性配位子結合機構の解明2007
- Author(s)
  宇野公之、大場伸紘、森山友美子、石川吉伸、富杉佳計、前田初男
- Organizer
  日本薬学会127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] 薬物代謝酵素CYP2C19の基質認識と一塩基多型の影響2007
- Author(s)
  宇野公之、佐々木隆一、Sayed M.S. Ali、小山由希子、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular Docking of Porphyrins with Cationic Limbs on Intramolecular G-quadruplex2007
- Author(s)
  石川吉伸、東栄希、森岡弘志
- Organizer
  第34回核酸化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular Modeling of Anti-parallel G-quadruplex DNA/TMPyP complexes2006
- Author(s)
  石川吉伸、富杉佳計、宇野公之
- Organizer
  第33回核酸化学シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2006-11-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Resonance Raman Studies of CYP2C19 and Its Complexes with Substrates2006
- Author(s)
  Sayed M. S. Ali, Yukiko Oyama, Yoshinobu Ishikawa, Yoshikazu Tomisugi, Hatsuo Maeda, and Tadayuki Uno
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Exogenous Ligand Binding Mechanism of Cytoglobin2006
- Author(s)
  Tadayuki Uno, Kaori Kukino, Hatsuo Maeda, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Norifumi Kawada, Katsutoshi Yoshizato, Hitomi Sawai, and Yoshitsugu Shiro
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] サイトグロビン及びニューログロビンの外来性配位子結合機構2006
- Author(s)
  宇野公之、久木野香里、堤紘子、龍大輔、前田初男、富杉佳計、石川吉伸、河田則文、吉里勝利、澤井仁美、城宜嗣
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Over-expression of Recombinant Human Hemoglobin2006
- Author(s)
  Tadayuki Uno, Takefumi Ishimaru, Sohtaro Takigawa, Yohei Hoashi, Toshiya Kai, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] CYP1A2の一塩基多型による薬物結合性と代謝活性の変化2006
- Author(s)
  宇野公之、江川真文、村田晋一、辻本景英、前田初男、富杉佳計、石川吉伸
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] 組換え型ヒトヘモグロビン大量発現系の構築2006
- Author(s)
  宇野公之、石丸武史、帆足洋平、甲斐俊哉、前田初男、富杉佳計、石川吉伸
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Substrate Binding and Metabolizing Properties of Indoleamine 2,3-Dioxygenase2006
- Author(s)
  Tadayuki Uno, Mai Ushida, Akemi Matsuura, Chikako Nakayama, Tomoko Hosokawa, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Roles of Cysteine Residues in the Gas Binding to Human Neuroglobin2006
- Author(s)
  Tadayuki Uno, Leila Hafsi, Hiroko Tsutsumi, Daisuke Ryu, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] キネシンEg5とATP競合阻害剤との複合体の結晶構造
- Author(s)
  横山英志、澤田潤一、加藤詩織、松野研司、小郷尚久、石川吉伸、藤井敏、浅井章良、橋本博
- Organizer
  平成26年度日本結晶学会年会
- Place of Presentation
  東京
- Year and Date
  2014-11-01 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] ギ酸誘導体の一酸化炭素生成機構およびこれを用いる実用的有機合成反応
- Author(s)
  小西英之、上田剛、松原美香、森敬介、石川吉伸、橋本博、常盤広明、眞鍋敬
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24590141

1. UNO Tadayuki (00183020)

# of Collaborated Projects : 4results

# of Collaborated Products : 4results
2. TOMISUGI Yoshikazu (80322311)

# of Collaborated Projects : 3results

# of Collaborated Products : 27results
3. YOKOYAMA Hideshi (70433208)

# of Collaborated Projects : 2results

# of Collaborated Products : 9results
4. MURATA Toshihiro (70458214)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
5. UMEHARA Kaoru (40185070)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
6. SUGANUMA Keisuke (60772184)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. SASAKI Kenroh (90244970)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
8. 芦澤忠 (10443441)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. 安藤隆幸 (40402226)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. SASAMOTO Kazumi

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. BATKHUU Javzan

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
12. DAVAAPUREV Bekh-Ochir

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. ODONTUYA Gendaram

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. SELENGE Erdenechimeg

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
15. IKEDA Masanori

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. KANNO Shin-ichiro

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. TAKIKAWA Osamu

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
18. FUJII Satoshi

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
19. MANABE Kei

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
20. KITA Yasuyuki

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
21. 原幸大

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
22. 橋本博

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
23. 田中耕三

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
24. 菱木麻美

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
25. 石川岳志

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
26. 小郷尚久

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
27. 常盤広明

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
28. 小西英之

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
29. 井川貴詞

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
30. 稲井誠

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
31. 菅敏幸

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
32. 江木正浩

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
33. 浅川倫宏

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

ISHIKAWA Yoshinobu 石川 吉伸

Research Projects

Research Products

Co-Researchers

In silicoによるPD-1/PD-L1阻害活性を持つ低分子化合物の同定Ongoing

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ハロゲン結合を基盤とするウレアーゼ阻害剤の開発Principal InvestigatorOngoing

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Bioactive compounds from Mongolian traditional medicinal plants and their effects evaluations to living organisms using insect

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SBDD targeting metalloenzyme RNA polymeraze of influenza virusPrincipal Investigator

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Synthesis and analysis of telomere quadruplex DNA-binding porphyrins based on an electrostatic interaction modelPrincipal Investigator

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Predicition and verification for the structures and thermodynamic properties of telomeric DNA quadruplex/porphyrin complexesPrincipal Investigator

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A Comprehensive Study on the Effects of Genetic Polymorphism on the Drug Metabolizing Activity of Human CYP

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テロメアDNA四重鎖構造を安定化させテロメラーゼを阻害するポルフィリンの開発Principal Investigator

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Studies on the Signal Transduction Mechanism by Gas Sensor Proteins

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Development of Porphyrin as a Molecular Cutter of Genes

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テロメア四重鎖DNAに作用する芳香族カチオン性ポルフィリンの開発Principal Investigator

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A STUDY ON DNA CLEAVAGE MECHANISM BY WATER-SOLUBLE PORPHYRINS

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[Book] in silico創薬におけるスクリーニングの高速化・高精度化技術2018

Author(s)

Total Pages

Publisher

ISHIKAWA Yoshinobu 石川吉伸