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FUJIMURA Atsushi  藤村 篤史

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Fujimura Atsushi  藤村 篤史

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Researcher Number 10771082
Other IDs
Affiliation (Current) 2022: 岡山大学, 医歯薬学域, 助教
Affiliation (based on the past Project Information) *help 2021 – 2022: 岡山大学, 医歯薬学域, 助教
2017 – 2020: 岡山大学, 医歯薬学総合研究科, 助教
2016: 熊本大学, 大学院生命科学研究部(医), 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / General physiology
Except Principal Investigator
Basic Section 52040:Radiological sciences-related / Basic Section 38040:Bioorganic chemistry-related / Basic Section 55040:Respiratory surgery-related
Keywords
Principal Investigator
tRNA修飾酵素 / 翻訳メカニズム / 癌幹細胞 / 低分子化合物スクリーニング / tRNA修飾 / 薬剤開発 / 癌転移・浸潤 / Hippo経路 / 創薬 / がん幹細胞 … More / 悪性脳腫瘍 / 微小環境 / tRNA修飾酵素群 / 癌の不均一性 / 膠芽腫幹細胞 / 低分子化合物開発 / エピトランスクリプトーム創薬 / がん幹細胞特異的翻訳 … More
Except Principal Investigator
同種造血幹細胞移植 / 閉塞性細気管支炎 / ホウ素中性子捕捉療法 / RNA修飾酵素 / 阻害剤 / 構造活性相関 / 肺癌 / 癌微小環境 / シュワン細胞 / 化学療法抵抗性 Less
  • Research Projects

    (6 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (27 People)
  •  新規抗がん剤開発を目指すtRNA修飾酵素と阻害化合物の構造活性相関解明

    • Principal Investigator
      安藤 隆幸
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38040:Bioorganic chemistry-related
    • Research Institution
      Shizuoka Institute of Environment and Hygiene
  •  Creating new therapies for lung cancer by targeting de-differentiated Schwann cells in the cancer microenvironment.

    • Principal Investigator
      大谷 悠介
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Okayama University
  •  新規ホウ素製剤による同種造血幹細胞移植後の閉塞性細気管支炎治療の開発

    • Principal Investigator
      西森 久和
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Okayama University
  •  膠芽腫幹細胞を標的としたtRNAメチル化酵素阻害剤による制がん戦略の構築Principal Investigator

    • Principal Investigator
      藤村 篤史
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Okayama University
  •  Development of anti-cancer strategy by targeting tRNA modification enzymesPrincipal Investigator

    • Principal Investigator
      Fujimura Atsushi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Okayama University
  •  Development of anticancer drugs based on the knowledge of the roles of Ftsj1-mediated tRNA modificationPrincipal Investigator

    • Principal Investigator
      Fujimura Atsushi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General physiology
    • Research Institution
      Okayama University
      Kumamoto University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

  • [Journal Article] Sympathetic and parasympathetic innervation in cancer: therapeutic implications2021

    • Author(s)
      Kamiya A, Hiyama T, Fujimura A, Yoshikawa S.
    • Journal Title

      Clin Auton Res.

      Volume: 31 Pages: 165-178

    • DOI

      10.1007/s10286-020-00724-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07618
  • [Journal Article] Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration Affiliations expand2021

    • Author(s)
      Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I.
    • Journal Title

      Acta Neuropathol Commun

      Volume: 9 Pages: 1-23

    • DOI

      10.1186/s40478-021-01124-7

    • NAID

      120006995391

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07618, KAKENHI-PROJECT-20K09325, KAKENHI-PROJECT-20K17931, KAKENHI-PROJECT-20K17969, KAKENHI-PROJECT-18K16560
  • [Journal Article] Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors2021

    • Author(s)
      Huang R, Fujimura A, Nakata E, Takihira S, Inoue H, Yoshikawa S, Hiyama T, Ozaki T, Kamiya A.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 557 Pages: 199-205

    • DOI

      10.1016/j.bbrc.2021.03.172

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07618
  • [Journal Article] Editorial: The Role of Epigenetic Modifications in Cancer Progression2021

    • Author(s)
      Fujimura A, Pei H, Zhang H, Sladitschek HL, Chang L.
    • Journal Title

      Front Oncol.

      Volume: 10 Pages: 617178-617178

    • DOI

      10.3389/fonc.2020.617178

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07618
  • [Journal Article] Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate (BSH) delivery system for boron neutron capture therapy (BNCT).2021

    • Author(s)
      Michiue H, Kitamatsu M, Fukunaga A, Tsuboi N, Fujimura A, Matsushita H, Igawa K, Kasai T, Kondo N, Matsui H, Furuya S.
    • Journal Title

      Journal of Controlled Release

      Volume: 330 Pages: 788-796

    • DOI

      10.1016/j.jconrel.2020.11.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07618, KAKENHI-PROJECT-20K08652, KAKENHI-PROJECT-18K07324, KAKENHI-PROJECT-18K08944
  • [Journal Article] Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma2021

    • Author(s)
      Castellan M, Guarnieri A, Fujimura A, Zanconato F, Battilana G, Panciera T, Sladitschek HL, Contessotto P, Citron A, Grilli A, Romano O, Bicciato S, Fassan M, Porcu, E, Rosato A, Cordenonsi M, Piccolo S.
    • Journal Title

      Nature Cancer

      Volume: 2 Pages: 174-188

    • DOI

      10.1038/s43018-020-00150-z

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07618
  • [Journal Article] Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma.2020

    • Author(s)
      Matsumoto Y , Ichikawa T , Kurozumi K , Otani Y , Fujimura A , Fujii K , Tomita Y , Hattori Y , Uneda A , Tsuboi N , Kaneda K , Makino K , Date I
    • Journal Title

      Acta Neuropathol Commun.

      Volume: ー Pages: 1-13

    • DOI

      10.1186/s40478-020-00916-7

    • NAID

      120006840780

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10865, KAKENHI-PROJECT-18K15241, KAKENHI-PROJECT-20K09325, KAKENHI-PROJECT-20K17969, KAKENHI-PROJECT-18K16560
  • [Journal Article] Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by <i>HEY1-NCOA2</i> Gene Fusion2020

    • Author(s)
      Uneda A, Kurozumi K, Fujimura A, Kamiya A, Hirose T, Yanai H, Date I.
    • Journal Title

      NMC Case Report Journal

      Volume: 7 Issue: 2 Pages: 47-52

    • DOI

      10.2176/nmccrj.cr.2019-0123

    • NAID

      130007825982

    • ISSN
      2188-4226
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15241, KAKENHI-PROJECT-20K17969
  • [Journal Article] In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy2020

    • Author(s)
      Fujimura A, Yasui S, Igawa K, Ueda A, Watanabe K, Hanafusa T, Ichikawa Y, Yoshihashi S, Tsuchida K, Kamiya A, Furuya S.
    • Journal Title

      Cells

      Volume: 9 Pages: 2149-2149

    • DOI

      10.3390/cells9102149

    • NAID

      120006900770

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07618
  • [Journal Article] 2-Methylthio Conversion of N6-Isopentenyladenosine in Mitochondrial tRNAs by CDK5RAP1 Promotes the Maintenance of Glioma-Initiating Cells.2019

    • Author(s)
      Yamamoto Takahiro、Fujimura Atsushi、Wei Fan-Yan、Shinojima Naoki、Kuroda Jun-ichiro、Mukasa Akitake、Tomizawa Kazuhito
    • Journal Title

      iScience

      Volume: 21 Pages: 42-56

    • DOI

      10.1016/j.isci.2019.10.012

    • NAID

      120006816645

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02865, KAKENHI-PROJECT-17KT0054, KAKENHI-PROJECT-18K15241, KAKENHI-PROJECT-17H04300, KAKENHI-PROJECT-18H02599
  • [Journal Article] Defective mitochondrial tRNA taurine modification activates global protcostress and leads to mitochondrial disease.2018

    • Author(s)
      Fakruddin, M., Wei, F. Y., Suzuki, T., Asano, K., Kaieda, T., Omori, A., Izumi, R., Fujimura, A., Kaitsuka, T., Miyata, K., Araki, K., Oike, Y., Scorrano, L., Suzuki, T. and Tomizawa, K.
    • Journal Title

      Cell Rep

      Volume: 22 Pages: 482-496

    • DOI

      10.1016/j.celrep.2017.12.051

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17KT0054, KAKENHI-PROJECT-26702035, KAKENHI-PROJECT-26220205, KAKENHI-PROJECT-16K15482, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K19521, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-16K18989, KAKENHI-PROJECT-18H02599
  • [Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion2017

    • Author(s)
      Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Pages: 435-445

    • DOI

      10.1093/nar/gkw745

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-16K15194, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-16K18989, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16H05107
  • [Journal Article] Mtu1-mediated thiouridine formation of mitochondrial tRNAs is required for mitochondrial translation and is involved in reversible infantile liver injury.2016

    • Author(s)
      Wu, Y., Wei, F. Y., Kawarada, L., Suzuki, T., Araki, K., Komohara, Y., Fujimura, A., Kaitsuka, T., Takeya, M., Oike, Y., Suzuki, T., Tomizawa, K.
    • Journal Title

      PLoS Genet.

      Volume: 12

    • DOI

      10.1371/journal.pgen.1006355

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26702035, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-16K18989, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-26220205
  • [Journal Article] HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies.2016

    • Author(s)
      Mohd. Raeed Jamiruddin, Taku Kaitsuka, Farzana Hakim, Atsushi Fujimura, Fan-Yan Wei, Hisato Saitoh, Kazuhito Tomizawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 481 Pages: 25-30

    • DOI

      10.1016/j.bbrc.2016.11.026

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K18971, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-16K18989, KAKENHI-PROJECT-15F15110
  • [Patent] RNAメチルトランスフェラーゼ阻害剤、そのスクリーニング方法、抗がん剤有効性判定マーカー、及びFTSJ1阻害剤の有効性予測のためのキット2020

    • Inventor(s)
      藤村篤史ら
    • Industrial Property Rights Holder
      藤村篤史ら
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20K07618
  • [Patent] がん治療のための剤、及び、その有効成分のスクリーニング方法2020

    • Inventor(s)
      藤村篤史
    • Industrial Property Rights Holder
      藤村篤史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-20K07618
  • [Patent] ホウ素中性子捕捉療法の効果を最適化するがん病巣組織評価2018

    • Inventor(s)
      藤村篤史、松井秀樹
    • Industrial Property Rights Holder
      藤村篤史、松井秀樹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18K15241
  • [Presentation] ミトコンドリアによる細胞障害性修飾核酸の解毒作用は悪性脳腫瘍幹細胞の維持に必須である2020

    • Author(s)
      (口頭発表)藤村篤史、山本隆広、魏范研、富澤一仁
    • Organizer
      第97回 日本生理学会(コロナ禍により、誌上開催)
    • Data Source
      KAKENHI-PROJECT-18K15241
  • [Presentation] Defining the molecular characteristics of boron compounds proposes the concept of precision medicine in BNCT field2018

    • Author(s)
      Seiji Yasui, Atsushi Fujimura, Hiroyuki Michiue, Yasuaki Ichikawa, Shuichi Furuya, Mitsunobu Kano, Hideki Matsui
    • Organizer
      ICNCT 18th
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15241
  • [Presentation] Lineage-restricted dedifferentiation of neurons by transient expression of YAP-TAZ2018

    • Author(s)
      藤村篤史
    • Organizer
      第95回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-16K18989
  • [Presentation] FTSJ1依存性翻訳機構による転写因子ネットワーク維持は悪性脳腫瘍幹細胞に必須である2017

    • Author(s)
      藤村篤史、山村遼介、山本隆広、魏范研、貝塚拓、富澤一仁
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      静岡県浜松市
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-16K18989
  • [Presentation] tRNA修飾酵素FTSJ1による癌進展制御機構2017

    • Author(s)
      山村遼介、藤村篤史、永芳友、魏范研、貝塚拓、富澤一仁
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      静岡県浜松市
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-16K18989
  • [Presentation] 修飾ヌクレオチドの排出機構2017

    • Author(s)
      森岡太意気、魏范研、藤村篤史、富澤一仁
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      静岡県浜松市
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-16K18989
  • [Presentation] Ftsj1 determines cancer stem cell-related traits of breast and gastric cancer2016

    • Author(s)
      Atsushi Fujimura, Ryosuke Yamamura, Yu Nagayoshi, Fan-Yan Wei, Taku Kaitsuka, Kazuhito Tomizawa
    • Organizer
      tRNA 26th Conference
    • Place of Presentation
      Jeju, South Korea
    • Year and Date
      2016-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K18989
  • 1.  石川 吉伸 (00305004)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  安藤 隆幸 (40402226)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  西森 久和 (70756064)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  前田 嘉信 (60403474)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  黒住 和彦 (20509608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  富澤 一仁 (40274287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  増本 年男 (40715083)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  中村 仁 (50828407)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  魏 范研 (90555773)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 10.  大谷 悠介 (90894270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  豊岡 伸一 (30397880)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  WATANABE Yasuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  NAKAYAMA Hideki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  MUKASA Akitake
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  SUZUKI Takeo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  MICHIUE Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  市川 智継
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  藤井 謙太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 19.  赤池 孝章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  澤 智裕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  石井 功
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  篠島 直樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  荒木 正健
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  荒木 喜美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 25.  鈴木 勉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 26.  貝塚 拓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  HAKIM FARZANA
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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