FUJIMURA Atsushi 藤村篤史

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Fujimura Atsushi 藤村篤史

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Researcher Number	10771082
Other IDs
Affiliation (Current)	2023: 岡山大学, 医歯薬学域, 研究准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 岡山大学, 医歯薬学域, 助教 2017 – 2020: 岡山大学, 医歯薬学総合研究科, 助教 2016: 熊本大学, 大学院生命科学研究部(医), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / General physiology Except Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 38040:Bioorganic chemistry-related / Basic Section 55040:Respiratory surgery-related / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator tRNA修飾酵素 / 翻訳メカニズム / がん幹細胞 / 癌幹細胞 / 低分子化合物スクリーニング / tRNA修飾 / 薬剤開発 / 癌転移・浸潤 / Hippo経路 / 創薬 … More / 悪性脳腫瘍 / 微小環境 / tRNA修飾酵素群 / 癌の不均一性 / 膠芽腫 / 翻訳制御機構 / タンパク質合成 / 低分子化合物 / 膠芽腫幹細胞 / 低分子化合物開発 / エピトランスクリプトーム創薬 / がん幹細胞特異的翻訳 / 腫瘍生物学 / 創薬標的 / メカノバイオロジー / 乳癌 … More Except Principal Investigator RNA修飾酵素 / 阻害剤 / 構造活性相関 / 肺癌 / 癌微小環境 / シュワン細胞 / 化学療法抵抗性 / 同種造血幹細胞移植 / 閉塞性細気管支炎 / ホウ素中性子捕捉療法 / 横紋筋肉腫 / がん幹細胞性 / 悪性末梢神経鞘腫瘍 / アドレナリン / 内在性カテコラミン合成経路 Less

乳癌進展におけるメカノ応答性翻訳センサーの分子機構の解明と抗癌剤開発基盤の創成Principal Investigator
- Principal Investigator
  
  藤村篤史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
脂質代謝による翻訳制御を標的とした横紋筋肉腫の革新的治療法の開発
- Principal Investigator
  
  板野拓人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
内在性カテコラミン合成経路を標的とした悪性末梢神経鞘腫瘍の新規治療方法の確立
- Principal Investigator
  
  片山晴喜
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
新規抗がん剤開発を目指すtRNA修飾酵素と阻害化合物の構造活性相関解明
- Principal Investigator
  
  安藤隆幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Shizuoka Institute of Environment and Hygiene
Creating new therapies for lung cancer by targeting de-differentiated Schwann cells in the cancer microenvironment.
- Principal Investigator
  
  大谷悠介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
新規ホウ素製剤による同種造血幹細胞移植後の閉塞性細気管支炎治療の開発
- Principal Investigator
  
  西森久和
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Okayama University
膠芽腫幹細胞を標的としたtRNAメチル化酵素阻害剤による制がん戦略の構築Principal Investigator
- Principal Investigator
  
  藤村篤史
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
Development of anti-cancer strategy by targeting tRNA modification enzymesPrincipal Investigator
- Principal Investigator
  
  Fujimura Atsushi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
Development of anticancer drugs based on the knowledge of the roles of Ftsj1-mediated tRNA modificationPrincipal Investigator
- Principal Investigator
  
  Fujimura Atsushi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Okayama University
  Kumamoto University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] Sympathetic and parasympathetic innervation in cancer: therapeutic implications2021
- Author(s)
  Kamiya A, Hiyama T, Fujimura A, Yoshikawa S.
- Journal Title
  
  Clin Auton Res.
  
  Volume: 31 Issue: 2 Pages: 165-178
- DOI
  10.1007/s10286-020-00724-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07618, KAKENHI-PROJECT-20H00666
[Journal Article] Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration2021
- Author(s)
  Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I.
- Journal Title
  
  Acta Neuropathol Commun.
  
  Volume: 9 Issue: 1 Pages: 29-29
- DOI
  10.1186/s40478-021-01124-7
- NAID
  120006995391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07618, KAKENHI-PROJECT-20K09325, KAKENHI-PROJECT-18K16560, KAKENHI-PROJECT-20K21897, KAKENHI-PROJECT-20K17969, KAKENHI-PROJECT-20H00666, KAKENHI-PROJECT-20K17931, KAKENHI-PROJECT-21K16632, KAKENHI-PROJECT-21K20803
[Journal Article] Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors2021
- Author(s)
  Huang R, Fujimura A, Nakata E, Takihira S, Inoue H, Yoshikawa S, Hiyama T, Ozaki T, Kamiya A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 557 Pages: 199-205
- DOI
  10.1016/j.bbrc.2021.03.172
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07618, KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-20K21897, KAKENHI-PROJECT-20H00666
[Journal Article] Editorial: The Role of Epigenetic Modifications in Cancer Progression2021
- Author(s)
  Fujimura A, Pei H, Zhang H, Sladitschek HL, Chang L.
- Journal Title
  
  Front Oncol.
  
  Volume: 10 Pages: 617178-617178
- DOI
  10.3389/fonc.2020.617178
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07618
[Journal Article] Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate (BSH) delivery system for boron neutron capture therapy (BNCT)2021
- Author(s)
  Michiue H, Kitamatsu M, Fukunaga A, Tsuboi N, Fujimura A, Matsushita H, Igawa K, Kasai T, Kondo N, Matsui H, Furuya S.
- Journal Title
  
  J Control Release.
  
  Volume: 330 Pages: 788-796
- DOI
  10.1016/j.jconrel.2020.11.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07618, KAKENHI-PROJECT-18K07324, KAKENHI-PROJECT-18K08944, KAKENHI-PROJECT-20K08652
[Journal Article] Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma2021
- Author(s)
  Castellan M, Guarnieri A, Fujimura A, Zanconato F, Battilana G, Panciera T, Sladitschek HL, Contessotto P, Citron A, Grilli A, Romano O, Bicciato S, Fassan M, Porcu, E, Rosato A, Cordenonsi M, Piccolo S.
- Journal Title
  
  Nature Cancer
  
  Volume: 2 Issue: 2 Pages: 174-188
- DOI
  10.1038/s43018-020-00150-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07618
[Journal Article] Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma2020
- Author(s)
  Matsumoto Y , Ichikawa T , Kurozumi K , Otani Y , Fujimura A , Fujii K , Tomita Y , Hattori Y , Uneda A , Tsuboi N , Kaneda K , Makino K , Date I
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: ー Issue: 1 Pages: 42-42
- DOI
  10.1186/s40478-020-00916-7
- NAID
  120006840780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10865, KAKENHI-PROJECT-18K15241, KAKENHI-PROJECT-20K09325, KAKENHI-PROJECT-20K17969, KAKENHI-PROJECT-18K16560
[Journal Article] Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by <i>HEY1-NCOA2</i> Gene Fusion2020
- Author(s)
  Uneda A, Kurozumi K, Fujimura A, Kamiya A, Hirose T, Yanai H, Date I.
- Journal Title
  
  NMC Case Report Journal
  
  Volume: 7 Issue: 2 Pages: 47-52
- DOI
  10.2176/nmccrj.cr.2019-0123
- NAID
  130007825982
- ISSN
  2188-4226
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15241, KAKENHI-PROJECT-20K17969
[Journal Article] In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy2020
- Author(s)
  Fujimura A, Yasui S, Igawa K, Ueda A, Watanabe K, Hanafusa T, Ichikawa Y, Yoshihashi S, Tsuchida K, Kamiya A, Furuya S.
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 10 Pages: 2149-2149
- DOI
  10.3390/cells9102149
- NAID
  120006900770
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07618
[Journal Article] 2-Methylthio Conversion of N6-Isopentenyladenosine in Mitochondrial tRNAs by CDK5RAP1 Promotes the Maintenance of Glioma-Initiating Cells2019
- Author(s)
  Yamamoto Takahiro、Fujimura Atsushi、Wei Fan-Yan、Shinojima Naoki、Kuroda Jun-ichiro、Mukasa Akitake、Tomizawa Kazuhito
- Journal Title
  
  iScience
  
  Volume: 21 Pages: 42-56
- DOI
  10.1016/j.isci.2019.10.012
- NAID
  120006816645
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02865, KAKENHI-PROJECT-17KT0054, KAKENHI-PROJECT-18K15241, KAKENHI-PROJECT-17H04300, KAKENHI-PROJECT-18H02599
[Journal Article] Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.2018
- Author(s)
  Fakruddin M, Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K.
- Journal Title
  
  Cell Rep.
  
  Volume: 22 Issue: 2 Pages: 482-496
- DOI
  10.1016/j.celrep.2017.12.051
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0054, KAKENHI-PROJECT-26702035, KAKENHI-PROJECT-26220205, KAKENHI-PROJECT-16K15482, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K19521, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-16K18989, KAKENHI-PROJECT-18H02599
[Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.2017
- Author(s)
  Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 45 Issue: 1 Pages: 435-445
- DOI
  10.1093/nar/gkw745
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-16K15194, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-16K18989, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16H05107
[Journal Article] Mtu1-mediated thiouridine formation of mitochondrial tRNAs is required for mitochondrial translation and is involved in reversible infantile liver injury2016
- Author(s)
  Wu, Y., Wei, F. Y., Kawarada, L., Suzuki, T., Araki, K., Komohara, Y., Fujimura, A., Kaitsuka, T., Takeya, M., Oike, Y., Suzuki, T., Tomizawa, K.
- Journal Title
  
  PLoS genetics
  
  Volume: 12 Issue: 9 Pages: e1006355-e1006355
- DOI
  10.1371/journal.pgen.1006355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26702035, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-16K18989, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-26220205
[Journal Article] HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies.2016
- Author(s)
  Mohd. Raeed Jamiruddin, Taku Kaitsuka, Farzana Hakim, Atsushi Fujimura, Fan-Yan Wei, Hisato Saitoh, Kazuhito Tomizawa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 481 Issue: 1-2 Pages: 25-30
- DOI
  10.1016/j.bbrc.2016.11.026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18971, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-16K18989, KAKENHI-PROJECT-15F15110
[Patent] ＲＮＡメチルトランスフェラーゼ阻害剤、そのスクリーニング方法、抗がん剤有効性判定マーカー、及びＦＴＳＪ１阻害剤の有効性予測のためのキット2020
- Inventor(s)
  藤村篤史ら
- Industrial Property Rights Holder
  藤村篤史ら
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20K07618
[Patent] がん治療のための剤、及び、その有効成分のスクリーニング方法2020
- Inventor(s)
  藤村篤史
- Industrial Property Rights Holder
  藤村篤史
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07618
[Patent] ホウ素中性子捕捉療法の効果を最適化するがん病巣組織評価2018
- Inventor(s)
  藤村篤史、松井秀樹
- Industrial Property Rights Holder
  藤村篤史、松井秀樹
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18K15241
[Presentation] ミトコンドリアによる細胞障害性修飾核酸の解毒作用は悪性脳腫瘍幹細胞の維持に必須である2020
- Author(s)
  （口頭発表）藤村篤史、山本隆広、魏范研、富澤一仁
- Organizer
  第97回日本生理学会（コロナ禍により、誌上開催）
- Data Source
  KAKENHI-PROJECT-18K15241
[Presentation] Defining the molecular characteristics of boron compounds proposes the concept of precision medicine in BNCT field2018
- Author(s)
  Seiji Yasui, Atsushi Fujimura, Hiroyuki Michiue, Yasuaki Ichikawa, Shuichi Furuya, Mitsunobu Kano, Hideki Matsui
- Organizer
  ICNCT 18th
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15241
[Presentation] Lineage-restricted dedifferentiation of neurons by transient expression of YAP-TAZ2018
- Author(s)
  藤村篤史
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K18989
[Presentation] FTSJ1依存性翻訳機構による転写因子ネットワーク維持は悪性脳腫瘍幹細胞に必須である2017
- Author(s)
  藤村篤史、山村遼介、山本隆広、魏范研、貝塚拓、富澤一仁
- Organizer
  第９４回日本生理学会大会
- Place of Presentation
  静岡県浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K18989
[Presentation] tRNA修飾酵素FTSJ1による癌進展制御機構2017
- Author(s)
  山村遼介、藤村篤史、永芳友、魏范研、貝塚拓、富澤一仁
- Organizer
  第９４回日本生理学会大会
- Place of Presentation
  静岡県浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K18989
[Presentation] 修飾ヌクレオチドの排出機構2017
- Author(s)
  森岡太意気、魏范研、藤村篤史、富澤一仁
- Organizer
  第９４回日本生理学会大会
- Place of Presentation
  静岡県浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K18989
[Presentation] Ftsj1 determines cancer stem cell-related traits of breast and gastric cancer2016
- Author(s)
  Atsushi Fujimura, Ryosuke Yamamura, Yu Nagayoshi, Fan-Yan Wei, Taku Kaitsuka, Kazuhito Tomizawa
- Organizer
  tRNA 26th Conference
- Place of Presentation
  Jeju, South Korea
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18989

1. 石川吉伸 (00305004)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 安藤隆幸 (40402226)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 増本年男 (40715083)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 中田英二 (10649304)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 尾崎敏文 (40294459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 黒住和彦 (20509608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 富澤一仁 (40274287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 中村仁 (50828407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 魏范研 (90555773)

# of Collaborated Projects: 1 results

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10. 工藤晃大 (40911433)

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11. 大谷悠介 (90894270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 豊岡伸一 (30397880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 西森久和 (70756064)

# of Collaborated Projects: 1 results

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14. 前田嘉信 (60403474)

# of Collaborated Projects: 1 results

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15. 板野拓人 (40966652)

# of Collaborated Projects: 1 results

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16. 片山晴喜 (00962242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SUZUKI Takeo

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# of Collaborated Products: 1 results
18. 市川智継

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# of Collaborated Products: 1 results
19. 藤井謙太郎

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# of Collaborated Products: 1 results
20. 赤池孝章

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# of Collaborated Products: 1 results
21. 貝塚拓

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# of Collaborated Products: 1 results

FUJIMURA Atsushi 藤村 篤史

Fujimura Atsushi 藤村 篤史

Research Projects

Research Products

Co-Researchers

乳癌進展におけるメカノ応答性翻訳センサーの分子機構の解明と抗癌剤開発基盤の創成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂質代謝による翻訳制御を標的とした横紋筋肉腫の革新的治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

内在性カテコラミン合成経路を標的とした悪性末梢神経鞘腫瘍の新規治療方法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規抗がん剤開発を目指すtRNA修飾酵素と阻害化合物の構造活性相関解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creating new therapies for lung cancer by targeting de-differentiated Schwann cells in the cancer microenvironment.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規ホウ素製剤による同種造血幹細胞移植後の閉塞性細気管支炎治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膠芽腫幹細胞を標的としたtRNAメチル化酵素阻害剤による制がん戦略の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anti-cancer strategy by targeting tRNA modification enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anticancer drugs based on the knowledge of the roles of Ftsj1-mediated tRNA modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sympathetic and parasympathetic innervation in cancer: therapeutic implications2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration2021

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NAID

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[Journal Article] Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors2021

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[Journal Article] Editorial: The Role of Epigenetic Modifications in Cancer Progression2021

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FUJIMURA Atsushi 藤村篤史

Fujimura Atsushi 藤村篤史