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HARADA Nobuhiro  原田 信広

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… Alternative Names

原田 信広  ハラダ ノブヒロ

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Researcher Number 00189705
Other IDs
Affiliation (Current) 2025: 藤田医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2021 – 2023: 藤田医科大学, 医学部, 教授
2018 – 2019: 藤田医科大学, 医学部, 教授
2010 – 2017: 藤田保健衛生大学, 医学部, 教授
2013: 藤田保険衛生大学, 医学部, 教授
1998 – 2008: Fujita Health University School of Medicine, Professor, 医学部, 教授 … More
2006: FIJITAHEALTH UNIVERSITY, MEDICINE, PROFESSOR, 医学部医学科, 教授
2004 – 2006: 藤田保健衛生大学, 医学部・医学科, 教授
1996 – 1997: Fujita Health University, Institute for comprehensive Medical Science Associate Professor, 総合医科学研究所, 助教授
1994 – 1996: 藤田保健衛生大学, 医学部, 助教授
1995: 藤田保健衛生大学, 総合医科学研究所・分子遺伝学, 助教授
1993: 名古屋保健衛生大学, 医学部, 助教授
1991: Fujita Health University Institute for Comprehensive Medical Science Associate Professor, 総合医科学研究所, 助教授
1989 – 1990: 藤田学園保健衛生大学, 医学部, 助教授
1987 – 1988: 藤田学園保健衛生大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Endocrinology / 内分泌・代謝学 / Biological Sciences / Endocrinology / 代謝生物化学
Except Principal Investigator
Human pathology / Basic Section 56040:Obstetrics and gynecology-related / Animal production science / Obstetrics and gynecology / Eating habits, studies on eating habits … More / 食生活 / Human pathology / Applied animal science / Genome biology / Applied animal science / Metabolomics / Biological Sciences Less
Keywords
Principal Investigator
アロマターゼ / エストロゲン / Aromatase / 組織特異的発現 / Cyp1B1 / ステロイドサルファターゼ / トランスジェニックマウス / ノックアウトマウス / エストロゲン合成酵素 / Estrogen … More / breast cancer / 乳癌 / multiple exons 1 / estrogen / 骨粗鬆症 / 多重エクソン1 / プロテアソーム / ユビキチン化 / リン酸化 / 翻訳後修飾 / 性分化 / チトクロ-ムPー450_<AROM> / アロマタ-ゼ / BeWo細胞 / Phosphorylation / Chaperone / Ubiouitination / Proteasome / Protein Degradation / Post-translational Modification / ユビキチンリガーゼ / 代謝回転速度 / 酵素誘導 / シャペロン / 細胞内分解 / Estrogen sulfotransferase / Steroid sulfatase / Knockout mouse / Transgenic mouse / エストロン硫酸転移酵素 / エストロゲン硫酸抱合化酵素 / aromatase knockout mice / fluorescent probe / estrogen sulfotransferase / CVP IB 1 / steroid sulfatase / aromatase / SNP / 発癌感受性 / 17β-水酸化ステロイド脱水素酵素 / ホルモン療法 / 炎症性サイトカイン / OAT-3 / siRNA / GFP / ナロマターゼ / 細胞間相互作用 / エストロゲン依存性癌 / アロマターゼ欠損マウス / 蛍光プローブ / エストロゲン硫酸転移酵素 / cyp1B1 / Multiple promoters / Tissue-specific expression / Sexual differentiation of the brain / trasgenic mouse / knockout mouse / 組織特異的転写因子 / 多重プロモーター / 脳の性分化 / nuclear DNA binding factor / age-related disease / tissue-specific expression / switching / 核内DNA結合因子 / 加齢 / スイッチング / arterial sclerosis / hormone-dependent cancer / osteoporosis / alternative splicing / cytochrome P-450 / 動脈硬化症 / ホルモン依存性癌 / 選択的スプライシング / チトクロームP450 / CAT assay / JEG-3 cell / Transcriptional regulation / Estrogen synthetase / CATアッセイ / JEGー3細胞 / 転写調節 / チトクロームP-450 / アロマターゼ遺伝子 / アロマターゼcDNA / ナトクロームP450 / 性周期 / 脱リン酸化 / カルシニューリン / カルモジュリン依存性キナーゼ / 神経内分泌 / 神経細胞 / 翻訳後調節 / 性行動 / 非遺伝子作用 / ポリコーム群タンパク質 / ヒストンH3 / ポリコーム / クロマチン構造 / ヒストン / メチル化 / アセチル化 / エピジェネティック / クロマチン / 内分泌学 / RTーPCR法 / 3T3-L1細胞 / チトクロ-ムP-450 / アロマタ-ゼ遺伝子 / アロマタ-ゼcDNA … More
Except Principal Investigator
アロマターゼ / エストロゲン / 遺伝子発現 / ニワトリ / 乳癌 / 子宮内膜癌 / CHOLESTEROL / FOOD FACTORS / AROMATASE / ATHEROSCLEROSIS / ESTROGEN / FEMALE HORMONE / ノックアウトマウス / 動脈硬化 / 性分化 / 生殖腺 / Dax-1 / mRNA / Sox-9 / AMH / Sf-1 / Dmrt-1 / P450 / クロマチン / 脳 / 大腸癌 / レチノイド / 17水酸化ステロイド脱水素酵素 / P450アロマターゼ / CYP1A1 / がん原物質活性化 / チトクロームP450 / 女性医学 / 食欲 / ニューロエストロゲン / マイクロサテライト不安定性 / estrogen receptor-beta / 高齢者 / エストロゲン受容体β / 性 / 閉経後 / 年齢 / 女性 / アッセイ / 血液 / 胚 / EIA / アロマターぜ / エストラジオール / ウズラ / 細胞分化 / 生殖医学 / 分化 / 栄養膜細胞 / 胎盤 / PROTECTION / KOCKOUT MOUSE / 女性ホルモン合成酵素 / アポE / PREVENTION / KNOCKOUT MOUSE / コレステロール / 予防 / 食事因子 / アルマターゼ / 女性ホルモン / receptor / retinoid / steroid metabolism / progesterone / androgen / estrogen / endometrial cancer / breast cancer / プロゲステロン受容体 / エストロゲン受容体 / レチノイド受容体 / 子宮内膜増殖症 / 5α-reductase / estrone sulfotransferase / steroid sulfatase / 受容体 / ステロイド代謝 / プロゲステロン / アンドロゲン / sexual differentiation / chicken embryo / アンドロジェンレセプター / 抗ミュラー管ホルモン / PCR / in situ hybridization / SOX9 / アンチセンスオリゴヌクレオチド / クローニング / RT-PCR / SRC-1 / Z性染色体 / Dmert-1 / 性決定 / ニワトリ胚 / aromatase / 性決定・性分化 / 鶏胚生殖腺 / Lung cancer / Genetic polymorphism / Metabolic activation / Mutation assay / Salmonella typhimurium / CYP3A4 / 遺伝子導入マウス / Ahレセプター / CYP1A2 / 発現系 / 発現制御 / DNAアダクト / トランスジェニックマウス / がん原物質 / 肺がん / 遺伝子多型 / 代謝的活性化 / 変異原性試験 / サルモネラ菌 / ヒストン修飾 / セントロメア / 次世代シーケンサー / CYP19 / プロモーター / 転写 / SEVENS法 / ヌクレオソーム / 高浸透圧刺激 / 転写因子 / TRPファミリー / アルギニンバソトシン / TonEBP / TPR / 転写調節因子 / 浸透圧刺激 / 抗利尿ホルモン / 浸透圧調節 / 脳・神経 / 性ステロイドホルモン / アルツハイマー病 / 老年病 / 性ホルモン / ステロイドサルファターゼ / ホルモン依存性腫瘍 / ホルモン環境 / 腫瘍 / 性ステロイド / 17β水酸化ステロイド脱水素酵素 / 一酸化窒素合成酵素 / CYP2B6 / 遺伝子導入動物 Less
  • Research Projects

    (29 results)
  • Research Products

    (72 results)
  • Co-Researchers

    (49 People)
  •  遺伝子改変マウスを用いたニューロエストロゲンが摂食行動に与える影響

    • Principal Investigator
      西尾 永司
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Fujita Health University
  •  The study of human trophoblast differentiation

    • Principal Investigator
      Ishihara Naoe
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Fujita Health University
  •  Chromatin structure as a determinant of transcriptional activity

    • Principal Investigator
      Ishihara Satoru
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Genome biology
    • Research Institution
      Fujita Health University
  •  Study of feminization mechanism of avian brain and regulation mechanism of aromatase gene expression

    • Principal Investigator
      Saito Noboru
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Animal production science
    • Research Institution
      Okayama University
  •  Post-translational dual regulation of cytochrome P450 aromatase responsible for non-genomic actions of estrogensPrincipal Investigator

    • Principal Investigator
      Harada Nobuhiro
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Fujita Health University
  •  Study on the pathological role of estrogens in colorectal cancer.

    • Principal Investigator
      HONMA Naoko
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Toho University
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  Study of regulation of anti-diuretic hormone gene expression

    • Principal Investigator
      SAITO Noboru
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied animal science
    • Research Institution
      Okayama University
      Nagoya University
  •  Epigenetic regulation of aromatase gene by changes of chromatin structurePrincipal Investigator

    • Principal Investigator
      HARADA Nobuhiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Fujita Health University
  •  Association between geriatric diseases and sex steroid hormones.

    • Principal Investigator
      HONMA Naoko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  Metabolic regulation of estrogen-synthesizing enzymes by post-translational modificationPrincipal Investigator

    • Principal Investigator
      HARADA Nobuhiro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Fujita Health University
  •  FOOD FACTORS THAT PROTECT ATHEROSCLEROSIS-ATTEMPTS USING MICE DEFICIENT IN FEMALE HORMONE SYNTHASE AND APOLIPOPROTEIN E GENES

    • Principal Investigator
      HARA Takayuki
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Eating habits, studies on eating habits
    • Research Institution
      NAKAMURA GAKUEN UNIVERSITY
  •  Endocrinological analysis of genetically modified mice with abnormal estrogen metablismPrincipal Investigator

    • Principal Investigator
      HARADA Nobuhiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Fujita Health University
  •  エストロゲン依存性癌におけるエストロゲン生合成と代謝に関する研究

    • Principal Investigator
      坂本 秀生
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Fujita Health University
  •  日米における乳癌、子宮内膜癌のホルモン環境の検討

    • Principal Investigator
      笹野 公伸
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Study on the protection against estrogen-dependent cancerPrincipal Investigator

    • Principal Investigator
      HARADA Nobuhiro
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      藤田保健衛生大学
  •  ROLE OF FEMALE HORMONE AND FOOD FACTORS IN PREVENTION OF ATHEROSCLEROSIS -INVESTIGATIONS USING KNOCKOUT MICE

    • Principal Investigator
      HARA Takayuki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      食生活
    • Research Institution
      NAKAMURA GAKUEN UNIVERSITY
  •  日米における乳癌・子宮内膜癌のホルモン環境の検討

    • Principal Investigator
      SASANO Hironobu
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  Metabolic activation of procarcinogens and cancer risk

    • Principal Investigator
      KAMATAKI Tetsuya
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  The analysis of intratumoral estrogen metabolism and production in human breast and endometrial carcinoma

    • Principal Investigator
      SASANO Hironobu
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Tohoku University
  •  Analysis of aromatase/estrogen system in the age-related diseases by developmental engineering techniquesPrincipal Investigator

    • Principal Investigator
      HARADA Nobuhiro
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Endocrinology
    • Research Institution
      Fujita Health University
  •  Molecular mechanisms of sex determination in birds

    • Principal Investigator
      SHIMADA Kiyoshi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Applied animal science
    • Research Institution
      NAGOYA UNIVERSITY
  •  Molecular mechanism of aberrant expression of estrogen synthetase in the age-related diseasesPrincipal Investigator

    • Principal Investigator
      HARADA Nobuhiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Fujita Health University
  •  Analysis on switching of alternative exons 1 causing aberrant expression of estrogen synthetasePrincipal Investigator

    • Principal Investigator
      NOBUHIRO Harada
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Fujita Health University
  •  チトクロームP450を利用したがん原性のシュミレーションと発がんの感受性の解析

    • Principal Investigator
      KAMATAKI Tetsuya
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  チトクロ-ムPー450_<AROM>の生理機能と発現制御Principal Investigator

    • Principal Investigator
      原田 信広
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Fujita Health University
  •  Analysis on the transcriptional regulation mechanism of aromatase genePrincipal Investigator

    • Principal Investigator
      HARADA Nobuhiro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      Fujita Health University
  •  チトクロ-ムP-450・アロマタ-ゼの生理機能と発現制御機構の解析Principal Investigator

    • Principal Investigator
      原田 信広
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Fujita Health University
  •  ユニークなP-450・アロマターゼの構造・生理機能・局在の分子レベルでの解析Principal Investigator

    • Principal Investigator
      原田 信広
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Fujita Health University
  •  性分化と性周期発現の遺伝的制御機構-アロマターゼの誘導調節を中心として-Principal Investigator

    • Principal Investigator
      原田 信広
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Fujita Health University

All 2017 2016 2015 2014 2013 2012 2011 2010 2008 2007 2005 2004 2002 2001 2000 Other

All Journal Article Presentation Book

  • [Book] Resistance to Aromatase Inhibitors in Breast Cancer2015

    • Author(s)
      Harada Nobuhiro
    • Total Pages
      19
    • Publisher
      Springer International Publishing Switzerland
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Book] Brain Aromatase, Estrogens, and Behavior (Oxford series in Begavioral Neuroendocrinology)2013

    • Author(s)
      Harada N, Honda S-I.
    • Publisher
      Oxford University Press
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Book] Brain Aromatase, Estrogens, and Behavior2012

    • Author(s)
      Nobuhiro Harada & Shin-ichiro Honda
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Journal Article] The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene2015

    • Author(s)
      Kotomura, N.,Harada, N., & Ishihara, S.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0128282-e0128282

    • DOI

      10.1371/journal.pone.0128282

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25461398, KAKENHI-PROJECT-26430188
  • [Journal Article] Aromatase controls Sjogren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages2015

    • Author(s)
      Iwasa A, Arakaki R, Honma N, Ushio A, Yamada A, Kondo T, Kurosawa E, Kujiraoka S, Tsunematsu T, Kudo Y, Tanaka E, Yoshimura N, Harada N, Hayashi Y, Ishimaru N.
    • Journal Title

      Am J Pathol

      Volume: 185 Issue: 1 Pages: 151-161

    • DOI

      10.1016/j.ajpath.2014.09.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-14J04314, KAKENHI-PROJECT-14J08922, KAKENHI-PROJECT-25461398
  • [Journal Article] Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters2015

    • Author(s)
      Kurokawa, J., Sasano, T., Kodama, M., Li, M., Ebana, Y., Harada, N., Honda, S.-I., Nakaya, H., & Furukawa, T.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 40 Issue: 3 Pages: 339-348

    • DOI

      10.2131/jts.40.339

    • NAID

      130005068413

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461398, KAKENHI-PROJECT-26460334, KAKENHI-PROJECT-15K15049, KAKENHI-PROJECT-15H04684, KAKENHI-PROJECT-14J40079, KAKENHI-PROJECT-26293052
  • [Journal Article] Post-translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation2014

    • Author(s)
      Hayashi, T. & Harada, N.
    • Journal Title

      FEBS J.

      Volume: 281 Issue: 21 Pages: 4830-4840

    • DOI

      10.1111/febs.13021

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Journal Article] Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis2014

    • Author(s)
      Takayoshi Ubuka, Shogo Haraguchi, Yasuko Tobari, Misato Narihiro, Kei Ishikawa, Takanori Hayashi, Nobuhiro Harada , Kazuyoshi Tsutsui
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 3061-3061

    • DOI

      10.1038/ncomms4061

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-11J10683, KAKENHI-PLANNED-22132004, KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-23570091, KAKENHI-PROJECT-25461398
  • [Journal Article] Calcineurin and CRTC2 mediate FSH and TGFbeta1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells2014

    • Author(s)
      Lai, W. A., Yeh, Y. T., Fang, W. L., Wu, L. S., Harada, N., Wang, P. H., Ke, F. C., Lee, W. L., & Hwang, J. J.
    • Journal Title

      J. Mol. Endocrinol.

      Volume: 53 Issue: 2 Pages: 259-270

    • DOI

      10.1530/jme-14-0048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Journal Article] LIM-homeodomain transcription factor, Lhx2, is involved in transcriptional control of brain-specific promoter/exon 1f of the mouse aromatase gene2012

    • Author(s)
      Honda S-I, Kozako T, Shimeno H, Soeda S, Harada N.
    • Journal Title

      J Neuroendocrinol

      Volume: 24 Pages: 1367-1374

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23580388
  • [Journal Article] Aromatase expression in the brain of the ruffed grouse (Bonasa umbellus) and comparisons with other galliform birds (Aves, Galliformes)2012

    • Author(s)
      Cornfield JR, Harada N, Iwaniuk AN.
    • Journal Title

      J Chem Neuroanat

      Volume: 47 Pages: 15-27

    • DOI

      10.1016/j.jchemneu.2012.12.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23580388, KAKENHI-PROJECT-25461398
  • [Journal Article] Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice2012

    • Author(s)
      Li R, He P, Cui J, Staufenbiel M, Harada N, Shen Y.
    • Journal Title

      Mol Neurobiol

      Volume: 47 Issue: 3 Pages: 857-867

    • DOI

      10.1007/s12035-012-8377-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23580388, KAKENHI-PROJECT-25461398
  • [Journal Article] Human and quail arom-atase activity is rapidly and reversibly inhibited by phosphorylating condi2011

    • Author(s)
      Charlier TD, Harada N, Balthazart J
    • Journal Title

      Endocrinology

      Volume: 152(11) Issue: 11 Pages: 4199-4210

    • DOI

      10.1210/en.2011-0119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591019, KAKENHI-PROJECT-23580388
  • [Journal Article] Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathological role of androstene-3b, 17b-diol2011

    • Author(s)
      Honma, N., Saji, S., Hirose, M., Horiguchi, S., Kuroi, K., Hayashi, S., Utsumi, T., & Harada, N.
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 10 Pages: 1848-1854

    • DOI

      10.1111/j.1349-7006.2011.02018.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23580388
  • [Journal Article] Sex differences in brain aromatase activity : genomic and non-genomic controls2011

    • Author(s)
      Balthazart, J., Charlier, T.D., Cornil, C.A., Dickens, M.J., Harada, N., Konkle, A.T.M., Voigt, C., Ball, G.F.
    • Journal Title

      Front. Neuroendocrin

      Volume: 2 Pages: 34-34

    • DOI

      10.3389/fendo.2011.00034

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23580388
  • [Journal Article] Behavioral analysis of genetically modified mice indicates essential roles2011

    • Author(s)
      Honda S-I, Wakatsuki T, Harada
    • Journal Title

      Front

      Volume: 2 Pages: 40-40

    • DOI

      10.3389/fendo.2011.00040

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591019, KAKENHI-PROJECT-23580388, KAKENHI-PROJECT-23591360
  • [Journal Article] Estradiol promotes Purkinje dendritic growth, spinogenesis and synaptogenesis during neonatal life by inducing the expression of BDNF2011

    • Author(s)
      Shogo Haraguchi
    • Journal Title

      The Cerebellum

      Volume: (in press) Issue: 2 Pages: 416-417

    • DOI

      10.1007/s12311-011-0342-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10683, KAKENHI-PLANNED-22132004, KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-22591019, KAKENHI-PROJECT-23580388
  • [Journal Article] 1-(2,4-Dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl) propane inhibits melanin synthesis by dual mechanism2011

    • Author(s)
      Niki, Y., Yoshida, M., Ando, H., Wakamatsu, K., et al
    • Journal Title

      J.Dermatol.Sci.

      Volume: 63 Pages: 115-121

    • DOI

      10.1016/j.jdermsci.2011.04.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500358, KAKENHI-PROJECT-21580163, KAKENHI-PROJECT-23580388
  • [Journal Article] Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates β-secretase (BACW1) and prevents Alzheimer-like pathology and cognitive impairment.2010

    • Author(s)
      McAllister G, Long J, Bowers A, Walker A, Cao P, Honda S-I, Harada N, Staufenbiel M, Shen Y, Li R.
    • Journal Title

      J Neurosci

      Volume: 30 (21) Issue: 21 Pages: 7326-7334

    • DOI

      10.1523/jneurosci.1180-10.2010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Journal Article] Insulin-like growth factor 1 enhances the aromatase P450 expression by inhibiting auto- phagy2010

    • Author(s)
      Zhang B, Shozu M, Okada M, Ishikawa H, Kasai T, Murakami K, Nomura K, Harada N, Inoue M
    • Journal Title

      Endocrinology

      Volume: 151(10) Issue: 10 Pages: 4949-4958

    • DOI

      10.1210/en.2010-0294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Journal Article] The characteristics of aromatase deficient hairless mice indicate important roles of extragonadal estrogen in the skin.2008

    • Author(s)
      Tsukahara, K., Kakuo, S., Moriwaki, S., Hotta, M., Ohuchi, A., Kitahara, T., Harada, N.
    • Journal Title

      J. Steroid Biochem. Mol. Biol. 108

      Pages: 82-90

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591034
  • [Journal Article] Oestrogen receptor-beta1 but not oestrogen receptor-betacx is of prognostic value in apocrine carcinoma of the breast.2008

    • Author(s)
      Honma N, Saji S, Kurabayashi R, Aida J, Arai T, Horii R, Akiyama F, Iwase T, Harada N, Younes M et al
    • Journal Title

      APMIS 116(10)

      Pages: 923-930

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590376
  • [Journal Article] Expression of oestrogen receptor-beta in apocrine carcinomas of the breast.2007

    • Author(s)
      Honma N, Takubo K, Akiyama F, Kasumi F, Sawabe M, Arai T, Hosoi T, Yoshimura N, Harada N, Younes M et al
    • Journal Title

      Histopathology 50(4)

      Pages: 425-433

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590376
  • [Journal Article] Mode of action and functional significance of estrogen-induced dendritic growth, spinogenesis, and synaptogenesis in the developing Purkinje cell.2007

    • Author(s)
      Sasahara, K., Shikimi, H., Haraguchi, S., Sakamoto, H., Honda, S., Harada, N., Tsutsui, K.
    • Journal Title

      J. Neurosci 27

      Pages: 7408-7414

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591034
  • [Journal Article] Concomitant treatment of severe uterine adenomyosis in a Premenopausal woman with an aromatase inhibitor and a gonadotropin-releasing hormone agonist.2007

    • Author(s)
      Kimura, F., Takahashi, K., Takebayashi, K., Fujiwara, M., Kita, N., Noda, Y., Harada, N.
    • Journal Title

      Fertil. Steril 87

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591034
  • [Journal Article] Analysis of spatiotemporal regulation of aromatase in the brain by transgenic mice.2005

    • Author(s)
      Harada, N.
    • Journal Title

      J.Steroid Biochem.Mol.Biol. 95

      Pages: 49-55

    • Data Source
      KAKENHI-PROJECT-16590916
  • [Journal Article] Analysis of spatiotemporal regulation of aromatase in the brain by transgenic mice.2005

    • Author(s)
      Harada, N.
    • Journal Title

      J. Steroid Biochem. Mol. Biol. 95

      Pages: 49-55

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590916
  • [Journal Article] Analysis of spatiotemporal regulation of aromatase in the brain by transgenic mice.2005

    • Author(s)
      Harada, N., etc.
    • Journal Title

      J.Steroid Biochem.Mol.Biol. 95

      Pages: 49-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590916
  • [Journal Article] Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer.2004

    • Author(s)
      Yoshimura N, Harada N, Bukholm I, Karesen R, Borresen-Dale A-L, Kristensen VN.
    • Journal Title

      Breast Cancer Res. 6

      Pages: 46-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213132
  • [Journal Article] Semi-quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast.2002

    • Author(s)
      Zhang Z, Yamashita H, Toyama T, Hara Y, Omoto Y, Sugiura H, Kobayashi S, Harada N, Iwase H.
    • Journal Title

      Breast Cancer Res. Treat. 74

      Pages: 47-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213132
  • [Journal Article] Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies2001

    • Author(s)
      Harada N
    • Journal Title

      J.Steroid Biochem.Mol.Biol. 79

      Pages: 151-156

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12213132
  • [Journal Article] Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies.2001

    • Author(s)
      Harada N, Matsumoto T, Yoshimura N, Sakamoto H, Honda S.
    • Journal Title

      J. Steroid Biochem. Mol. Biol. 79

      Pages: 151-156

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213132
  • [Journal Article] Correlation of cyclin D1 mRNA levels with clinico-pathological parameters and clinical outcome in human breast carcinoma.2000

    • Author(s)
      Utsumi T, Yoshimura N, Maruta M, Mizoguchi Y, Harada N.
    • Journal Title

      Int.J.Cancer 89

      Pages: 39-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213132
  • [Journal Article] Elevated steroid sulfatase expression in breast cancers.2000

    • Author(s)
      Utsumi T, Yoshimura N, Takeuchi S, Maruta M, Maeda K, Harada, N.
    • Journal Title

      J.Steroid Biochem.Mol.Biol. 73

      Pages: 141-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213132
  • [Journal Article] Genetic variations of Cyp19 (aromatase) and breast cancer risk.2000

    • Author(s)
      Kristensen VN, Harada N, Yoshimura N, Haraldsen E, Lonning PE, Erikstein B, Karesen RM, Kristensen T, Borresen-Dale A-L.
    • Journal Title

      Oncogene 19

      Pages: 1329-1333

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213132
  • [Journal Article] Tumor-stimulating ability of stromal cells in human breast cancer tissues through the estrogen-signaling pathway.

    • Author(s)
      Yamaguchi Y, Takei H, Suemasu K, Kobayashi Y, Kurosumi M, Harada N, Hayashi S.
    • Journal Title

      Cancer Res. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213132
  • [Presentation] 卵巣顆粒膜細胞でのCYP19遺伝子は2カ所のオープンクロマチン領域によって転写調節される2017

    • Author(s)
      琴村直恵、原田信広、石原悟
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-16K11118
  • [Presentation] アロマターゼの翻訳後修飾による発現調節2016

    • Author(s)
      原田信広、林孝典
    • Organizer
      第23回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      倉敷芸文館
    • Year and Date
      2016-01-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] 神経内アロマターゼに対する神経伝達物質の影響とメカニズム2016

    • Author(s)
      林孝典、原田信広
    • Organizer
      日本ステロイドホルモン学会学術集会
    • Place of Presentation
      ホルトホール大分
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] 神経内アロマターゼによるニューロエストロゲン合成の調節機構2016

    • Author(s)
      林孝典、原田信広
    • Organizer
      第23回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      倉敷芸文館
    • Year and Date
      2016-01-15
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] エストロゲン長期枯渇は乳がん細胞PP2Aを減少させる2015

    • Author(s)
      林孝典、引地理浩、内海俊明、原田信広
    • Organizer
      第16回ホルモンと癌研究会
    • Place of Presentation
      朝日大学村上記念病院
    • Year and Date
      2015-07-10
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] アロマターゼ翻訳後修飾を介した神経伝達物質のニューロエストロゲン合成調節2015

    • Author(s)
      林孝典、原田信広
    • Organizer
      第38下位日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] 神経刺激により惹起される脳内エストロゲン合成酵素・アロマターゼのリン酸化・脱リン酸化の重要な役割2015

    • Author(s)
      原田信広、林孝典
    • Organizer
      第38下位日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] ユビキチン-プロテアソーム系によるニューロエストロゲンの合成調節機構2015

    • Author(s)
      林孝典、原田信広
    • Organizer
      第20回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      ANAクラウンプラザホテルグランコート名古屋
    • Year and Date
      2015-08-21
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] Rapid dual regulation of cyp19A1 (P450arom) in nerve cells as neuroestrogen synthase2015

    • Author(s)
      Harada, N. & Hayashi, T.
    • Organizer
      19th International Conference on Cytochrome P450
    • Place of Presentation
      International Exchange Building in the National Olympics Memorial Youth Center
    • Year and Date
      2015-06-12
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] Transcriptional and Post-Transcriptional Regulation of Aromatase in the Mouse Brain2012

    • Author(s)
      Nobuhiro Harada
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & cancer
    • Place of Presentation
      Kanazawa
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] プロモーターの転写活性を決めるクロマチン構造2012

    • Author(s)
      琴村直恵、原田信広、石原悟
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] The stability of P450arom is controlled by Ca2+ -dependent phosphorylation and dephosphorylation.2012

    • Author(s)
      Hayashi T, Munetsuna E, & Harada N.
    • Organizer
      15th Inter- national Congress on Hormonal Steroids and Hormones & Cancer;
    • Place of Presentation
      Kanazawa, Japan.
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] Ca2+依存的リン酸化はエストロゲン合成酵素アロマターゼの活性・安定性を調節する.2012

    • Author(s)
      林孝典、宗綱栄二、原田信広
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] アロマターゼの脳特異的発現に関与する転写因子Deaf-1の機能ドメインの解析2012

    • Author(s)
      本田伸一郎、大下遥子、民本愛、小迫知弘、蔵元佑嘉子、元流梨恵、原田信広、添田秦司.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] A dense chromatin structure select- ively represses a promoter(s) of the CYP19 gene producing several trans- cripts by alternative promoter usage.2012

    • Author(s)
      Kotomura N, Harada N, Ishihara S.
    • Organizer
      第6回日本エピジェネティック研究会年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] Transcriptional and post-translational regulation of aromatase in the mouse brain.2012

    • Author(s)
      Harada N & Honda S-I.
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer;
    • Place of Presentation
      Kanazawa, Japan.
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] Condensed chromatin marked by K27-trimethylated histone H3 deter- mines alternative promoter usage of the CYP19 gene.2011

    • Author(s)
      Kotomura N, Harada N, Ishihara S
    • Organizer
      CDB Symposium2011: Epigenetic Landscape in Devel- opment and Diseases
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] エストロゲン合成酵素P450aromの安定性はCa2+依存性リン酸化・脱リン酸化による制御される.2011

    • Author(s)
      林孝典、原田信広
    • Organizer
      第84回日本生化学会大会合同大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] Function and regulation of aromatase/estrogen in the brain.2011 International Mini-Conference on Translational Neuroscience: Neuro- logical2011

    • Author(s)
      Harada N
    • Organizer
      Disorders and Psychiatric Diseases (IMCOTN-NDPD)
    • Place of Presentation
      Beijing, China
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] The contribution of histone modifi- cations to alternative promoter usage of the human CYP19 gene.2011

    • Author(s)
      Kotomura N, Harada N, Ishihara S.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] ヒストンH3K27トリメチル化によるアロマターゼ遺伝子プロモーターの選択的不活性化2011

    • Author(s)
      石原悟、琴村直恵、西芳寛、野村政壽、柳瀬敏彦、原田信広
    • Organizer
      第19回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] Ca2+依存性リン酸化・脱リン酸化によるエストロゲン合成酵素P450aromの分解制御される.2011

    • Author(s)
      林孝典、原田信広
    • Organizer
      第19回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] Condensed chromatin marked by K27-trimethylated histone H3 deter- mines alternative promoter usage of the CYP19 gene.2011

    • Author(s)
      Kotomura N, Harada N, Ishihara S
    • Organizer
      第5回日本エピジェネティ ック研究会年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] エストロゲン合成酵素アロマターゼの安定性はリン酸化によって制御される2010

    • Author(s)
      林孝典、若月徹、吉村憲子、原田信広
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] アロマターゼ遺伝子CYP19のプロモーター選択に関するエピジェネティックス解析2010

    • Author(s)
      石原悟、琴村直恵、原田信広
    • Organizer
      第18回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22591019
  • [Presentation] 術後tamoxifen単独補助療法後乳癌におけるestrogen receptor-β探索の臨床的重要性2008

    • Author(s)
      本間尚子, 堀井理絵, 岩瀬拓士, 佐治重衡, 田久保海誉, 内海俊明, 原田信広, 松浦正明, 伊藤良則, 秋山太
    • Organizer
      第9回ホルモンと癌研究会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-19590376
  • [Presentation] Physiological functions and local production of estrogens by extra-gonadal aromatase.2007

    • Author(s)
      Nobuhiro Harada
    • Organizer
      The annual meeting of Biochemistry and Molecular Biology(The annual joint meeting of The Japanese Biochemical Society and The Molecular Biology Society of Japan)
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591034
  • [Presentation] 乳腺アポクリン癌におけるestrogen receptor-betaの臨床病理学的意義2007

    • Author(s)
      本間尚子, 佐治重衡, 戸井雅和, 田久保海誉, 堀井理絵, 秋山太, 岩瀬拓士, Mamoun Younes, Jan-Ake Gustafsson, 吉村憲子, 原田信広, 坂元吾偉
    • Organizer
      第8回ホルモンと癌研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590376
  • [Presentation] 性腺外アロマターゼによるエストロゲンの局所産生と生理機能2007

    • Author(s)
      原田 信広
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591034
  • [Presentation] A biphasic post-translational regulation of cyp19A1 (P450AROM) by phosphorylation/dephophorylation

    • Author(s)
      Hayashi T, Munetsuna E, Harada N.
    • Organizer
      18th International Conference on Cytochrome P450
    • Place of Presentation
      University of Washington (Seattle)
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] エストロゲンの非遺伝子作用を担うアロマターゼの翻訳後二段階調節機構

    • Author(s)
      原田信広、林孝典、宗綱栄二
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] 神経細胞に発現するアロマターゼのリン酸化とユビキチン化によるニューロエストロゲン合成制御

    • Author(s)
      林孝典、原田信広
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館( 京都府、京都市 )
    • Year and Date
      2014-10-17 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] 転写量を反映するYP19遺伝子プロモーターのクロマチン構造

    • Author(s)
      琴村直恵、原田信広、石原悟
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] Genomic and non-genomic regulation of brain aromatase

    • Author(s)
      Nobuhiro Harada
    • Organizer
      The Endocrine Society's 95th Annual Meeting & Expo
    • Place of Presentation
      Moscone Center (San Francisco)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] 神経内アロマターゼの活性及び安定性調節機構

    • Author(s)
      林孝典、宗綱栄二、原田信広
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-25461398
  • [Presentation] アロマターゼの活性及び安定性の調節

    • Author(s)
      林孝典、宗綱栄二、原田信広
    • Organizer
      日本ステロイドホルモン学会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中)
    • Data Source
      KAKENHI-PROJECT-25461398
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