KAMATAKI Tetsuya 鎌滝哲也

… Alternative Names

鎌瀧哲也カマタキテツヤ

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Researcher Number	00009177
Other IDs
Affiliation (based on the past Project Information) *help	2007: 高崎健康福祉大, 薬学部, 教授 2006: 高崎健康福祉大学, 薬学部, 教授 2004 – 2005: Hokkaido University, Professor, 大学院薬学研究科, 教授 1998 – 2005: Fac.of Pharm.Sci., Hokkaido Univ., Prof., 大学院・薬学研究科, 教授 1998: 北海道大学, 大学院薬学研究科, 教授 1986 – 1998: 北海道大学, 薬学部, 教授 1986: 北海道大学, 薬学部・薬品分析化学教室, 教授
Review Section/Research Field	Principal Investigator Biological pharmacy / Environmental pharmacy / Biological Sciences / Medical pharmacy / 広領域 Except Principal Investigator Biological pharmacy / 応用薬理学・医療系薬学 / Environmental pharmacy / 補綴理工系歯学 / Medical pharmacy / Laboratory animal science / Biological Sciences
Keywords	Principal Investigator P450 / チトクロームP450 / トランスジェニックマウス / 遺伝子多型 / CYP2A6 / 薬物代謝 / チトクロームP-450 / CYP1A2 / 代謝的活性化 / 個人差 … More / CYP3A7 / FMO / クローニング / 発現系 / CYP2D6 / 胎児 / アフラトキシンB_1 / 薬物代謝酵素 / サルモネラ菌 / CYP3A4 / がん原物質活性化 / CYP1A1 / P450アロマターゼ / 遺伝病 / ノックアウトマウス / トリメチルアミン / 代謝欠損 / 遺伝子治療 / がん / タバコ / ニトロソアミン / 煙草 / テーラーメイド / 抗がん薬 / 肝ミクロゾーム / P-450IIIA / Nuclear polyhedorosis virus / チトクロ-ムPー450 / Cytochrome P-450 / Poor metabolizer / カフェイン / CYP2C / 肺がん / CYP / 発現調節 / バキュロウイルス発現系 / 大量発現系 / genetic polymorphism / P450 2A6 / whole gene deletion / 胎児毒性 / p53 / C / EBPα / fetal toxicity / COX / 性差 / 遺伝子導入動物 / CYP2B6 / 一酸化窒素合成酵素 / パーキンソン病 / MPTP / TIQ / cDNAクローニング / ヒト型マウス / 肺がんリスク / ニコチン / 遺伝子欠損型多型 / 寿命制御遺伝子 / SNP / スプライシング / 酵素活性 / 癌 / チトクロームPー450 / 変異原物質活性化 / ヒト / サル / イヌ / 肝臓 / SRalphaプロモーター / デキサメタゾン / チトクロムPー450 / Pー450IIIA / SF9細胞 / nuclear polyhedorosis virus / umu試験 / ヒト胎児肝 / 細胞毒性試験 / 転写調節機構 / MCFー7 / Pー450HFLa / Pー450_<NF> / Fetus / Liver / Aflatoxin B_1 / SRalpha promoter / Dexamethasone / N-アセチル転移酵素 / 多型性 / チトクローム P450 / poor metabolizer / S-メフェニトイン / P-450IID6 / P-450IIC / 遺伝的多型性 / P-450IA2 / eytensive metabolizer / Cytochrome P450 / Caffeine / N-acetyltransferase / Polymorphism / 変異原性試験 / がん原物質 / DNAアダクト / 発現制御 / アロマターゼ / Ahレセプター / 遺伝子導入マウス / Salmonella typhimurium / Mutation assay / Metabolic activation / Genetic polymorphism / Lung cancer / 胎児特異的 / fetus-specific / transgenicmouse / bioactivation / 代替法 / p53欠損マウス / 細胞発現系 / 肝細胞 / p53欠失マウス / N-アセチルトランスフェラーゼ / in vitro 毒性試験 / Alternatives / Transgenic mouse / p53-Knockout mouse / Cell expression system / Hepatocyte / 遺伝的多型 / 異種細胞発現系 / ヒトゲノム / 遺伝子解析 / trimethylamine / genetic disease / gene therapy / heterologous expression / human genome / gene analysis / ハイスループット / プレートリーダー / 阻害 / 薬物相互作用 / 遺伝子組換え / 医薬品開発 / ハイスループットシステム / 大腸菌発現系 / チトクロームb_5 / 薬物間相互作用 / 水溶性ポリマー / HIGH THROUGH PUT / PLATE READER / INHIBITION / DRUG METANBOISM / DRUG INTERACTION / RECOMBINANT / DRUG DEVELOPMENT / P450 1A2 / 全欠損型変異 / 芳香族炭化水素受容体 / 扁平上皮がん / チトクロームP450 (CYP) / LBP-1 / AhRシグナル / 組織型 / 核移行 / チトクロームP450(CYP) / 口腔がん / Ahリセプター-リプレッサー(AhRR) / 遺伝子診断 / カテキン / 誘導的発現 / Ah受容体 / 発がんリスクの個体差 / tobacco / smoking / Ah receptor / Arnt / nicotine / nitosamine / 発生 / 転写制御 / CYP3A5 / ヒト肝 / 時期特異的発現調節 / development / gene regulation / transgenic mouse / サリドマイド / ヒト化マウス / 実験動物 / 催奇形性 / プロスタグランジンG / H合成酵素 / フェニトイン / thalidomide / transgenic mice / humanized mice / animal model / teratogenicity / 全欠損変異 / 薬物酸化 / NAT2 / 個別化医療 / オーダーメイド / individualized medicine / individual variation / cytochrome P450 / anti cancer drug / drug oxidation / 種差 / テストステロン / drug metabolism / sex differende / species difference / cytochrome P-450 / ハムスタ- / 肝ミクロゾ-ム / 精製 / チトクロ-ムP-450 / ハムスター / Hamster / Liver microsomes / Drug Metabolizing enzyme / Sex difference / Purification … More Except Principal Investigator 代謝的活性化 / poor metabolizer / 癌原性化学物質の代謝 / 癌原性化学物質への感受性 / 酵素誘導 / 薬物代謝 / CYP2D6 / CYP3A7 / 遺伝子転写調節蛋白 / チトクロ-ムPー450遺伝子 / チトクロ-ムPー450cDNA / チトクロ-ムPー450蛋白 / アセチルトランスフェラ-ゼ / ヒト遺伝子のRFLPs / プロテインジスルフィドイソメラーゼ / カルレチクリン / LECラット / 自己免疫性抗体 / 肝炎 / 個人差 / 遺伝子多型 / 遺伝子 / ホスホリパーゼA_2 / SM-12502 / polymorphism / CYP2A6 / population study / HITECマウス / チトクロームP450 / HITEC mouse / Metabolic activation / AHR / CYP1A1 / CYP1B1 / P450 / IAP / チトクロームPー450遺伝子 / チトクロームPー450cDNA / チトクロームPー450蛋白 / アセチルトランスフェラーゼ / グルタチオンSートランスフェラーゼ / ヒト遺伝子のRFLP / ヒト胎児肝 / グルタチオンS-トランスフェラ-ゼ / グルタチオン / グルタチオンSトランスフェラ-ゼ / トランスジェニックマウス / 家族性アミロイドニュ-ロパシ- / 高血圧症モデル / ジ-ンタ-ゲッティング法 / 生物機能モデル / ヒト疾患モデル / 転写調節蛋白 / グルタチオンSートランスフェラ-ゼ / チトクロ-ムPー450 / エンケファリン / 合成ペプチド / ロイシンーエンケファリン / メチオニンーエンケファリン / 動物実験代替 / 生体適合性試験指標 / 顎骨骨芽細胞 / 口腔粘膜上皮モデル / 薬物代謝酵素cDNA導入細胞系 / ヒト好中球 / 歯科材料 / 口腔粘膜モデル / 薬物代謝酵素遺伝子 / 活性酵素 / ヒト歯髄細胞 / プロスタグランジンE_2 / FMO3 / トリメチルアミン / 薬物相互作用 / 体臭 / チトクロムP-450遺伝子 / 5上流塩基配列 / チトクロムP-450mRNA / ヒト胎児遺伝子 / ラット肝遺伝子 / ビーグル犬肝チトクロムP-450 / 抗癌剤 / マウス / ヒト / ファーマコキネテックス / 薬剤感受性 / スクリーニングシステム / チトクロムP450遺伝子 / チトクロムP450mRNA / ラット肺チトクロムP450遺伝子 / ヒト胎児チトクロムP450遺伝子 / 5′上流域の塩基配列 / チトクロームP450遺伝子 / チトクロームP450mRNA / ハムスター肺P450 / 遺伝子転写制御領域 / 誘導剤と結合する受容体 / シグナル認識粒子 / ヒトのRFLP / ヘム蛋白質 / 脂溶性生理活性物質 / 薬物の酸化的代謝 / 分子多様性 / 細胞胞内局在性 / ミトコンドリア / ミクロソーム / 遺伝子発現 / 外挿 / 動物種差 / 遺伝子相同性 / 実験動物 / 系統差 / アニマルスケールアップ / 遺伝的相同性 / 遺伝情報 / 薬物代謝酵素 / 薬物代謝能 / 疾患遺伝子 / 膜酵素 / 肝臓薬物代謝酵素 / 遺伝子地図 / ジーンバンク / 動物脳シナプス膜脂質 / EXTRAPOLATION / SPECIES DIFFERENCES / GENE / PHARMACOKINETICS / GENETIC HOMOLOGY / LABORAATORY ANIMALS / STRAIN DIFFERENCES / ANIMAL SCALE UP / 重金属の毒性発現 / 種差 / 遺伝的多型性 / 紫外線B / 皮膚癌危険因子 / 酸化ストレス / 抗酸化酵素 / 大腸癌形成 / 活性酸素消去因子 / 重金属 / ダニアレルギー / HLAクラスII分子 / 電磁場 / 突然変異頻度 / 水銀化合物の腎毒性 / γ-グルタミルトランスペプチダーゼ / 抗原ペプチド / 極低周波電磁場 / DNA鎖修復 / 活性酸素 / 化学物質の毒性発現 / 免疫応答 / HLA分子 / 紫外線 / 色素性乾皮症 / Toxicity of Heavy metals / Species Difference / Drug Metabolism / Genetic Polymorphism / Ultraviolet Radiation B / Skin Cancer Risk Factor / Oxidative Stress / Antioxidative Enzymes / 薬物性肝障害 / アルコール性肝障害 / Autoimmune antibodies / LEC rats / Hepatitis / Protein disulfide isomerase / Cyclosporin-A / D-Penicillamine / 食虫目実験動物 / スンクス / 嘔吐 / 脂肪肝 / 生体防御 / 発ガン性 / 飼育繁殖 / 発癌性 / Insectivore / Suncus murinus / emesis / Fatty Liver / Biophylaxis / Carcinogenesis / Breeding and Reproduction / 遺伝子診断 / クマリン / poor mtabolizer / チトクロームP450 2D6 / チトクロームP450 2A6 / drugmetabolism / 発がん / CYP1A2 / genotyping / coumarin / 胎児特異的 / アフラトキシンB1 / 突然変異検出系 / アフラトキシンB_1 / Mutagenicity testing / Cytochrome P450 / Fetus-specific / Aflatoxin B1 / DNA damage / ポリフェノール / エビガロカテキンガレート / ベンツ[a]ピレン / 突然変異検出 / 化学発癌 / 遺伝子損傷 / エピガロカテキンガレート / epigallocatechin gallate / benzo[a]pyrene / mutagenesis / antimutagenesis / rpsL gene / 遺伝的多型 / 薬の効きすぎ / 遺伝子解析 / CYP2D636 / 薬の効き過ぎ / 遺伝的解析 / CYP2D6^10C / フレームシフト型変異 / drug metabolism / cytochrome P450 / genetic polymorphism / Adverse reaction / gene analysis / CYP2D6^*36 / がん / 環境要因 / 多段階発がん / 家系 / 免疫 / 発生工学 / 染色体 / 環境 / 細胞 / cancer / oncogenesis / gene / environmental factors / multistep carcinogenesis / immune system / chromosome / homeostasis / 多環芳香族炭化水素 / ダイオキシン / PAHs / TCDD / 胎児毒性 / CYP3A5 / サリドマイド / Tgマウス / ヒト型モデル / ヒト型モデル動物 / 胎仔全培養 / 奇形 / Toxicity / CYP2B6 / Thalidomide / Voriconazole / Pronofol / CYP3A / GTP結合蛋白質 / 細胞の増殖と分化 / 情報伝達系 / ホスホリパ-ゼA_2 / 3T3NIH^<ras> / 大脳皮質膜アデニル酸シクラ-ゼ / c-myc / 肝細胞 / アデニル酸シクラーゼ血小板トロンビン / セロトニン受容体 / IAPの化学修飾 / 免疫細胞系 / 増殖作用 / アデニレートシクラーゼ系 / 3T3線維芽細胞 / 甲状腺細胞 / GTP binding protein / Proliferation and differentiation of cells / Phospholipase A_2 / Signal transduction / NIH3T3^<ras> / Adenylate cyclase system Less

薬物代謝の個体差と個別化治療の基盤構築Principal Investigator
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Takasaki University of Health and Welfare
  Hokkaido University
薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらす薬物相互作用と疾病の個人差
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Molecular mechanism of chemical-induced toxicity in fetal livers
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa Pharmaceutical University
Basic Research for Individualized MedicinePrincipal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
Molecular Mechanisms of Toxic Expression Induced by Endocrine Disruptors via AHR
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
In vivo model to predict human fetal toxicity of xenobiotics : Establishment and evaluation of humanized mice carrying multiple forms of human fetal drug metabolizing enzymes.Principal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya, 藤田健一
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
CYP2A6のpharmacogenomics的研究Principal Investigator
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokkaido University
Function of activation and deactivation enzymes for carcinogens-s and risk for cancerPrincipal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Transcriptional regulation of the CYP3A7 gene specifically expressed in the human fetal liver.Principal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Metabolic activation of procarcinogens and cancer riskPrincipal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
ANALYSIS OF GENE MUTATION IN THAI CAUSING FISH ODOR SYNDROMEPrincipal Investigator
- Principal Investigator
  
  KAMATAKL Tetsuya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Mechanisms of oncogenesis and anti-oncogenesis
- Principal Investigator
  
  SASAZUKI Takehiko
- Project Period (FY)
  1999 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  International Medical Center of Japan
  Kyushu University
Developmental study for effective high-through-put screening system for new drug registrationPrincipal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
GENETIC POLYMORPHISM OF DRUG METABOLIZING-ENZYME ; ANALYSIS OF NOVEL POLYMORPHISM AND DEVELOPMENT OF GENOTYPING METHOD
- Principal Investigator
  
  ARIYOSHI Noritaka
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
魚臭症候群の原因となるフラビン含有モノオキシゲナーゼ遺伝子の解析Principal Investigator
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
APPLICATION OF TRANSGENIC MICE TO THE TOXICOLOGICAL TESTING
- Principal Investigator
  
  NAKAYAMA Kazuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
Evaluation of the antimutagenic effect of (-)-epegallocatechin gallate (EGCG) against chemical-induced mutagenesis of transgenic HITEC mice
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kanazawa University
Usefulness of Suncus murinus as a new experimental animal model
- Principal Investigator
  
  MATSUKI Norio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
Pharmacogenetics of drug metabolizing enzymes
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
歯科材料の生物学的評価のための動物実験代替法の開発
- Principal Investigator
  
  佐藤温重
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Tokyo Medical and Dental University
Analysis of human fetus-specific cytochrome P450 : Evaluation of its function (s) by using transgenic mice and estimation of regulation mechnism (S).Principal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
DEVELOPMENT OF NOVEL ALTERNATIVE METHODS FOR THE PREDICTION OF DRUG METABOLISM IN HUMANSPrincipal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
チトクロームP450を利用したがん原性のシュミレーションと発がんの感受性の解析Principal Investigator
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
パーキンソン病の原因解明:脳内におけるMPTP及びその類似化合物の代謝を司る酵素系の同定及びcDNAクローニングPrincipal Investigator
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Genetic Determinants Affecting Sensitivity to Environmental Factors-
- Principal Investigator
  
  IMURA Nobumasa
- Project Period (FY)
  1993 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
Can the Occurence of Autoantibody to Protein Disulfide Isomerase be a Marker for the Development of Hepatitis?
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
特異自己免疫抗体の出現は劇症肝炎発生の原因か?肝炎自然発症(LEC)ラットをモデルとして
- Principal Investigator
  
  横井毅
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
A COMPREHENSIVE RESEARCH FOR EXTRAPOLATION--GENETIC HOMOLOGY BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS
- Principal Investigator
  
  KASAI Noriyuki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  TOHOKU UNIVERSITY
  Hokkaido University
チトクロ-ムPー450を中心とした薬物代謝酵素遺伝子発現と化学発癌
- Principal Investigator
  
  渡辺民朗
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
チトクロ-ムPー450の新しい生理的意義に関する研究ー内因性生理活性ペプチドの調節における役割ー
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
System for the regulation of in vivo drug concentration ; Analyzes of genetic polymorphisms of drug metabolizing enzymesPrincipal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Basic study for dunction and gene regulation of human fetal liver P-450Principal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
チトクロームPー450を中心とした薬物代謝酵素遺伝子発現と化学発癌
- Principal Investigator
  
  渡辺民朗
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
ヒト胎児肝に特異的に存在するグルタチオンS-トランスフェラ-ゼに関する研究
- Principal Investigator
  
  KITADA Mitsukazu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
チトクロ-ムPー450を中心とした薬物代謝酵素遺伝子発現と化学発癌
- Principal Investigator
  
  渡辺民朗
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
癌原性化学物質への感受性に関するチトクロームPー450遺伝子の発現とその調節
- Principal Investigator
  
  渡辺民朗
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
癌原・変異原物質を活性化するチトクロームP-450の発現と発癌リスクの予測Principal Investigator
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
チトクロームP-450の分子生物学:発現の分子機構
- Principal Investigator
  
  藤井義明
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Regulation of Sex-Specific Forms of Cytochrome P-450 : Cytochrome P-450 in Liver Microsomes of HamstersPrincipal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Hokkaido University
外来遺伝子DNA導入による新しいモデル動物の開発
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1987 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
癌原性化学物質への感受性に関与するチトクロムPー450遺伝子の発現とその調節
- Principal Investigator
  
  渡辺民朗
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
胎児性ヒト肝チトクロームPー450分子種の発現と発癌の相関性に関する研究Principal Investigator
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
癌原性化学物質への感受性に関与するチトクロムP-450遺伝子の発現とその調節
- Principal Investigator
  
  渡辺民朗
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
Molecular and biochemical studies on the species differences of cytochrome P-450 related to forms expressed specifically in respective male and female ratsPrincipal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Physiological roles of GTP binding protein associated with pertussis toxin (IAP) for the study of medicinal and diagnostic functions
- Principal Investigator
  
  TOKUMITSU Yukiko
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
マウスとヒトにおける抗癌剤の比較薬理学的解析
- Principal Investigator
  
  稲葉実
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research

All 2007 2006 2005 2004 2003 2002 2001

All Journal Article

[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.2007
- Author(s)
  Yamazaki H, Fujita H, Gunji T, Zhang Z, Kamataki T, Cashman JR, Shimizu, M
- Journal Title
  
  Mol.Genet.Metab. 90
  
  Pages: 58-63
- NAID
  120000971644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population2007
- Author(s)
  Yamazaki H, Fujita H, Gunji T, Zhang Z, Kamataki T, Cashman JR, Shimizu, M
- Journal Title
  
  Mol.Genet.Metab. 90
  
  Pages: 58-63
- NAID
  120000971644
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais2006
- Author(s)
  Peamkrasatam S, Sriwatanakul K, Kiyotani K, Fujieda M, Yamazaki H, Kamataki T and Yoovathaworn K
- Journal Title
  
  Drug Metab Pharmacokinet 21
  
  Pages: 475-484
- NAID
  10018658956
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.2006
- Author(s)
  Peamkrasatam S, Siwatanakul K, Kiyotani K, Fujieda M, Yamazaki H, Kamataki T, Yoovathaworn K
- Journal Title
  
  Drug Metab Pharmacokinet 21
  
  Pages: 475-484
- NAID
  10018658956
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.2005
- Author(s)
  Kamataki, T, et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 338(1)
  
  Pages: 306-310
- Data Source
  KAKENHI-PROJECT-17015001
[Journal Article] Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.2005
- Author(s)
  Kamataki, T, et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 338(1)
  
  Pages: 306-310
- Data Source
  KAKENHI-PROJECT-15209005
[Journal Article] and Imaida, K. Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female Ad mice.2004
- Author(s)
  Takeuchi, H., Saoo, K., Yokohira, M., Ikeda, M., Maeta, H., Miyazaki, M., Yamazaki, H., Kamataki, T.
- Journal Title
  
  Nucleic Acids Res. 32
  
  Pages: 3169-3179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213002
[Journal Article] Identification of deletion-junction site of CYP2A6^*4B allele lacking entire coding region of CYP2A6 in Japanese2004
- Author(s)
  Ariyoshi, N., Sekine, H., Nakayama, K., Saito, K., Miyamoto, A., Kamataki, T.
- Journal Title
  
  Pharmacogenetics 14
  
  Pages: 701-705
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213002
[Journal Article] Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers2004
- Author(s)
  Fujieda, M., Yamazaki, H., Saito, T., Kiyotani, K., Gyamfi, M.A., Sakurai, M., Dosaka-Akita, H., Sawamura, Y., Yokota J., Kunitoh, H., Kamataki, T.
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 2451-2458
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213002
[Journal Article] Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6^*9). Pharmacogenetics 13 : 689-695, 2003.2003
- Author(s)
  Kiyotani, K., Yamazaki, H., Fujieda, M., Iwano, S., Matsumura, K., Satarug, S., Ujjin, P., Shimada, T., Guengerich, F.P.Parkinson, A.Nakagawa, K., Honda, G, Ishizaki, T., Kamataki, T.
- Journal Title
  
  Cancer Res. 63
  
  Pages: 7581-7583
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213002
[Journal Article] Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.2002
- Author(s)
  Ariyoshi, N., Miyamoto, M., Umetsu, Y., Kunitoh, H., Dosaka-Akita, H., Sawamura, Y., Yokota, J., Nemoto, N., Sato, K., Kamataki, T.
- Journal Title
  
  Cancer Epidemiol.Biomark.Preven. 11
  
  Pages: 890-894
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213002
[Journal Article] CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka.2002
- Author(s)
  Topcu, Z., Chiba, I., Fujieda, M., Shibata, T., Ariyoshi, N., Yamazaki, H., Sevgican, F., Muthumala, M., Kobayashi, H., Kamataki, T.
- Journal Title
  
  Carcinogenesis 23
  
  Pages: 595-598
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213002
[Journal Article] Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase.2001
- Author(s)
  Fujita, K., Kamataki, T.
- Journal Title
  
  Environ.Mol.Mutagen. 38
  
  Pages: 329-338
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213002

1. YOKOI Tsuyoshi (70135226)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. FUJITA Ken-ichi (60281820)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
3. NAKAYAMA Kazuo (20261323)

# of Collaborated Projects: 8 results

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4. YAMAZAKI Hiroshi (30191274)

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5. ITOH Susumu (70223154)

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6. TAKAHASHI Yoshiki (80292019)

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KAMATAKI Tetsuya 鎌滝 哲也

鎌瀧 哲也 カマタキ テツヤ

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薬物代謝の個体差と個別化治療の基盤構築Principal Investigator

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Basic Research for Individualized MedicinePrincipal Investigator

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In vivo model to predict human fetal toxicity of xenobiotics : Establishment and evaluation of humanized mice carrying multiple forms of human fetal drug metabolizing enzymes.Principal Investigator

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CYP2A6のpharmacogenomics的研究Principal Investigator

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Function of activation and deactivation enzymes for carcinogens-s and risk for cancerPrincipal Investigator

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Transcriptional regulation of the CYP3A7 gene specifically expressed in the human fetal liver.Principal Investigator

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Metabolic activation of procarcinogens and cancer riskPrincipal Investigator

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ANALYSIS OF GENE MUTATION IN THAI CAUSING FISH ODOR SYNDROMEPrincipal Investigator

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Developmental study for effective high-through-put screening system for new drug registrationPrincipal Investigator

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KAMATAKI Tetsuya 鎌滝哲也

鎌瀧哲也カマタキテツヤ