KUDO Ichiro 工藤一郎

Researcher Number	30134612
External Links
Affiliation (based on the past Project Information) *help	1994 – 2007: 昭和大学, 薬学部, 教授 2000: 昭和大, 薬学部, 教授 1998: 昭和薬科大学, 薬学部, 教授 1986 – 1994: 東京大学, 薬学部, 助教授 1992: 東京大学薬学部, 助教授 1986: The University of Tokyo, 薬学部, 助教授 1985: 東京大学, 薬, 助教授
Review Section/Research Field	Principal Investigator Biological pharmacy / Pathological medical chemistry / Biological Sciences / Functional biochemistry / Biological pharmacy / Environmental pharmacy / Environmental pharmacy / 物質生物化学 / 代謝生物化学 Except Principal Investigator Biological pharmacy … More / 物質生物化学 / General medical chemistry / Biological pharmacy / Orthopaedic surgery / 応用薬理学・医療系薬学 / Functional basic dentistry / Functional biochemistry / Anesthesiology/Resuscitation studies / Chemical pharmacy / Biological Sciences / 内科学一般 Less
Keywords	Principal Investigator ホスホリパーゼA_2 / 炎症 / アラキドン酸代謝 / ホスホリパーゼA2 / シクロオキシゲナーゼ / アラキドン酸 / ノックアウトマウス / リン脂質 / ホスホリパ-ゼA_2 / 血小板活性化因子 … More / PAF / inflammation / ホスホリバーゼA_2 / PGE_2 / ビメンチン / プロスタグランジン / TNF / 肥満細胞 / phospholipase A2 / Hsp90 / PGE2 / Arachidonic acid / Cyclooxygenase / マクロファージ / arachidonic acid / phospholipase A_2 / 肺サーファクタント / トランスジェニックマウス / 精子 / 癌 / グリピカン / ホスホリパーゼD / リン酸化 / 肝障害 / プロスタサイクリン / 血管内皮細胞 / Candida parapsilosis / differentiation / cell proliferation / bone marrow cells / M-CSF / cytokines / platelet-activating factor / PAFアンタゴニスト / 殺キャンデイダ作用 / DNA合成 / 分化 / 骨髄細胞 / lipocortin / gene cloning / rheumatoid arthritis / platelet / complement / 抗炎症剤 / デキサメサゾン / 抗炎症タンパク / 補体 / アナフィラキシ-反応 / アルザス反応 / 関節炎 / Cholineacetyltransferase / Phospholipase D / Platelet activating factor / コリンアセチルトランスフェラーゼ / platelet activating factor / macrophage / glyceroglycolipids / Alkylphospholipids / 糖脂質 / リゾリン脂質 / 抗腫瘍活性 / グリセログリコリリピド / アルキルホスホリピド / metabolic syndrome / lipoprotein / transgenic mice / knockout mice / arachidonate metabolism / phospholipid / Ca2+非依存的PLA2 / 細胞質PLA2 / 分泌性PLA2 / 雄性生殖器 / リウマチ / 肺炎 / リゾホスファチジルコリン / アデノウイルス / 免疫組織化学 / 生活習慣病 / リポ蛋白質 / トランジェニックマウス / ホスホリパーゼ / Inflamamtory / Colon tumors / PGE_2 synthase / 大腸癌 / PGE2合成酵素 / イソプレニル化 / ボスホリパーゼA2 / Phospholipid / Prostagrandin / Phospholipase A_2 / アポトーシス / COX / sPLA_2 / cPLA_2 / prostaglandin / cyclooxygenase / macrophages / neutrophils / mast cells / 遅発相 / 即時相 / サイトカイン / プロスタノイド / 好中球 / immediate allergy / PAF-acetylhydrolase / breast carcinoma / diabetes / multi-organ dysfunction / nephritis / phospholipases A_2 / 乳ガン細胞 / 即時型アレルギー / PAFアセチルヒドロラーゼ / 乳癌細胞 / 糖尿病 / 多臓器不全 / 腎盂炎 / phosphorylation / MAP kinase / MAPキナーゼ / アラキドン酸カスケード / liver injury / Phospholipase A2 / Ischemia / 臨界ミセル濃度 / 虚血心筋 / 血液凝固 / 肝臓障害 / 酸素ストレス / 虚血 / 神経突起 / 脂肪組織 / 筋肉 / ミトコンドリア / sPLA2 / 分子シャペロン / 胎生致死 / cPGES / 脂質 / 生殖 / 内分泌撹乱物質 / シグナル伝達 / 環境 / 免疫組織化学染色 / PGE合成酵素 / ホスファチジル基転移反応 / ホスファチジルアルセノコリン / アルセノコリン / ヒ素 / ピメンチン / ヘパラン硫酸プロテオグリカン / プライミング / 抗体 / 臨界シセル濃度 / リゾホスホリパーゼ / 血小板 / ヘパラン硫酸 / 速度論的解析 … More Except Principal Investigator ホスホリパーゼA_2 / 炎症 / PAF / ノックアウトマウス / アラキドン酸 / ホスホリパーゼ / ホスファチジルセリン / PGE2 / プロスタグランジン / マクロファージ / 血小板活性化因子 / TNF / 肥満細胞 / モノクロ-ナル抗体 / arachidonate metabolism / アラキドン酸代謝 / PGE合成酵素 / 破骨細胞 / IL-7 / Smad / 受容体 / phospholipase A2 / IL-6 / phospholipases / シグナル伝達 / inflammation / ヒスタミン / Prostaglandins / リポポリサッカライド / 脳 / 無脳回症 / カルシウムイオン / ACAT / 血管内皮細胞 / 繊維芽細胞 / 脱顆粒反応 / ホスファチジルコリン / ホスホリパ-ゼA_2 / thrombosis / auto antibody / autoimmunity / soy bean lipids / allergy / phospholipids / monoclonal antibody / ホスファチジルイノシトール4、5二燐酸 / モノクローナル抗体 / 脾内免疫法 / 動脈硬化 / リポプロテイン / 血栓症 / 自己抗体 / 自己免疫 / 大豆油 / アレルギ- / ホスホリパ-ゼ / リン脂質 / nitrogen cavitation / subcelluar localization / purification / degranuration / calcium ion / platelets / ホスホリパ-ゼAAA2BB / ヒト血小板 / ウサギ血小板 / Urogastron / Processing / Secreetion vector / Outer membrance of E.coli / Signal sequence / ホスホリパーゼ分泌ベクター / ウロガストロン遺伝子 / 細胞外分泌 / 組換えDNA / 大腸菌 / プロセシング / リゾチーム / ウロガステロン / 分泌ベクター / 大腸菌外膜 / シグナル配列 / anti-inflammatory drug / cancer / iknockout mice / cyclooxygenase / PGE synthase / prostaglandin E2 / PGE2合成酵素 / 免疫組織化学 / RGE_2合成酵素 / 抗炎症薬 / 生殖 / 潰瘍性大腸炎 / プロスタグランジンE2 / 解熱鎮痛抗炎症薬 / 癌 / シクロオキシゲナーゼ / PGE_2合成酵素 / PGE_2 / osteoarthritis / fracture repair / osteoporosis / arthritis / knockout mouse / bone resorption / bone / prostaglandin / サイクロオキシナーゼ / サイクロオキシグナーゼ / 疼痛 / プロスタグラジン / 変形性関節症 / 骨折治癒 / 骨粗鬆症 / 関節炎 / 骨吸収 / 骨 / Macrophages / Inducible enzyme / PDE synthase / Cyclooxygenase / Arachidonate Metabolites / トロンボキサンB_2 / プロスタグランジンD_2 / プロスタグランジンE_2 / シクロオキシゲナーゼ-2 / シクロオキシゲナーゼ-1 / PGI_2 / エンドトキシン / PGI2 / COX-2 / ODF / Estrogen / BMP / myoblast / osteoclast / osteoblast / 波状縁 / gp130 / インターロイキン-7 / エストロゲン / NF-κB / 筋芽細胞 / 骨誘導因子 / PHT受容体 / IL-1 / TNFファミリー / 破骨細胞分化因子(ODF) / エストロゲン受容体 / 卵巣摘出術 / 骨誘導因子(BMP) / 骨芽細胞 / Hydrolase / Receptor / Endocannabinoid / Arachidonic acid / 2-Arachidonoylglycerol / Anandamide / Marijuana / Cannabinoid / アミド水解酵素 / 幻覚物質 / アラキドニルエタノールアミン / アミダーゼ / 2-アラキドニルグリセロール / アラキドニルエタノールアミド / 加水分解酵素 / エンドカンナビノイド / 2-アラキドノイルグリセロール / アナンダミド / マリファナ / カンナビノイド / infection / shock / trauma / ischemia / small intestine / multiple organ dysfunction syndrome / adult respiratory distress syndrome / 好中球エラスターゼ / IL-8 / 敗血症性ショック / 出血性ショック / 感染症 / ショック / 外傷 / 虚血 / 小腸 / 多臓器不全 / 成人型呼吸促迫症候群 / protein kinase C / lipid mediators / 低分子量Gタンパク質 / 神経可塑性 / プロスタノイド / グリア細胞 / Miller-Dieker / 開口放出 / 低分子量Gタンパク / プロテインキナーゼC / 脂質メディエーター / Antioxidative Enzymes / Oxidative Stress / Skin Cancer Risk Factor / Ultraviolet Radiation B / Genetic Polymorphism / Drug Metabolism / Species Difference / Toxicity of Heavy metals / 色素性乾皮症 / 紫外線 / HLA分子 / 免疫応答 / 化学物質の毒性発現 / 活性酸素 / DNA鎖修復 / 極低周波電磁場 / 抗原ペプチド / γ-グルタミルトランスペプチダーゼ / 水銀化合物の腎毒性 / 突然変異頻度 / 電磁場 / HLAクラスII分子 / ダニアレルギー / 重金属 / 活性酸素消去因子 / 大腸癌形成 / 抗酸化酵素 / 酸化ストレス / 皮膚癌危険因子 / 紫外線B / 遺伝的多型性 / 薬物代謝 / 種差 / 重金属の毒性発現 / arachidonate / phospholipase A_2 / histamine / histidine decarboxylase / mast cell function / チロシンキナーゼ / 脱顆粒 / ヒスタミン合成 / プロテインキナーゼ / elastase / エラスターゼ / 翻訳後修飾 / ヒスチジンデカルボキシラーゼ / 肥満細胞機能 / lissencephaly / platelet activating factor / Calcium ion / Degranulation / Mast cell / Inflammation / Phospholipase A_2 / ロイコトリエン / 肝細胞 / 酸化脂肪酸 / WD-40リピート / ヒト無脳回症 / PAF受容体 / セリンエステラーゼ / 酸化リン脂質 / cholesterol transport / cholesterol / steroid / azole / ACAT inhibitor / foam cell / macrophage / 細胞内輸送 / コレステロ-ル / パ-パクチン / 阻害剤 / 抗真菌剤 / シクロデプシペプチド / マクロファ-ジ / ピリピロペン / グリソプレニン / コレステロール輸送 / コレステロール / ステロイド系阻害剤 / アゾール系抗真菌剤 / ACAT阻害剤 / 泡沫化 / ラット心臓 / 心筋虚血 / ホスホリパーゼC / ホスホリパーゼA / 心虚血 / 過酸化脂質 / アテローム性動脈硬化 / フォーム化 / リポソーム / 脂質代謝 / アセチルハイドロラーゼ / リン脂質代謝 / HL-60細胞 / 選択的細胞毒性 / ヒト前骨髄系白血病細胞 / 分化 / ヒト骨髄細胞 / 抗腫瘍エーテルリピド / CBT / 実務実習 / OSCE / 共用試験 / 薬学教育 / 薬学 / AVRL-2 / Ndr-1 / プロテアーゼ / サイトカイン / MMIG / Hsc70 / リン酸化 / SCF / PYPAF-1 / アトピー性皮膚炎 / アポトーシス / PGD2 / MMIG-1 / NDRG1 / マスト細胞 / 薬物作用 / 医療薬学 / 細胞・分子薬学 / 細胞内情報伝達 / 細胞間情報伝達 / 神経・免疫・内分泌相関 / 病態 / 三量体G蛋白質 / Src型チロシンキナーゼ / 増殖 / 貧食 / 遊走 / 顆粒分泌 / 抗イディオタイプ抗体 / ニュ-ロトランスミッタ- / ホスファチジルイノミト-ル-4,5ニリン酸 / 膜融合 / シナプス小胞 / 血餅退縮 / 抗リン脂質抗体 / ホスホリパ-ゼA_1 / 血小板活性化 / 血小板凝集 Less

Functional analysis of phospholipase A2 by genetically modified mice and its biopharmaceutical applicationPrincipal Investigator
- Principal Investigator
  
  HARA Shuntaro, 工藤一郎
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
薬学実務実習開始前の臨床能力評価方法に関する調査研究
- Principal Investigator
  
  望月正隆
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoritsu University of Pharmacy
アラキドン酸代謝反応の異常亢進により惹起される細胞の癌性変化の解析Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
新しい視点に立った内分泌攪乱物質の毒性発現メカニズムの解析Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa University
Analyses of prostaglandin E synthases that represent a potential target for novel anti-inflammatory drugs
- Principal Investigator
  
  MURAKAMI Makoto
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
  Showa University
Analyses of phospholipase A_2 enzymes that are involved in signaling and non-signaling eventsPrincipal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Contribution of new prostaglandin E_2 synthase to bone resorptive pathology and clinical application of PGES inhibitor
- Principal Investigator
  
  YAMAMOTO Motoi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
マスト細胞の分化とアラキドン酸代謝酵素群の発現調節
- Principal Investigator
  
  村上誠
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
哺乳動物細胞の核画分に存在する新しいアラキドン酸カスケード制御因子の検索Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
高等動物ホスホリパーゼA_2の機能、発現、動態の総合評価Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Showa University
Analysis of prostaglandin E2 synthasesPrincipal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
カルシウム依存性ホスホリパーゼA_2(PLA_2)と相互作用する細胞因子の研究Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
ヒ素含有グリセロリン脂質の解析に基づいたヒ素の毒性発現メカニズムの衛生薬学的研究Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa University
加齢病態・疾病発病に関わる神経・免疫・内分泌相関の細胞分子・医療薬学的研究
- Principal Investigator
  
  野村靖幸
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Studies on mammalian Ca^<2+>-dependent phospholipase A_2sPrincipal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Functional coupling of arachidonate metabolizing enzymes
- Principal Investigator
  
  OH-ISHI Sachiko
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kitasato University
脂質ホルモンによる関節リウマチ滑膜・増殖機構の解析とその制御
- Principal Investigator
  
  HONDA Zen-ichiro
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Biosynthesis and metabolism of anandamide as an endogenous ligand for cannabinoid receptors
- Principal Investigator
  
  YAMAMOTO Shozo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
Development of bone metabolism improvement medicines based on the analysis of signal transduction
- Principal Investigator
  
  SUDA Tasuo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
Molecular mechanism of synaptic plasticity
- Principal Investigator
  
  SHIMIZU Takao
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Abnormal expression of phospholipases A_2 and human diseasesPrincipal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Showa University
Studies on the regulation of arachidonic acid metabolism using mast cells and neutrophils as model systemsPrincipal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
ROLES OF PHOSPHOLIPASE A_2 IN MULTIPLE ORGAN DYSFUNCTION SYNDROME
- Principal Investigator
  
  KOIKE Kaoru
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  NIPPON MEDICAL SCHOOL
Arachidonate-preferential cytosolic phospholipases A_2 as novel signal transducersPrincipal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Showa University
肥満細胞プライミング現象の生化学的および薬学的評価Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Genetic Determinants Affecting Sensitivity to Environmental Factors-
- Principal Investigator
  
  IMURA Nobumasa
- Project Period (FY)
  1993 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
血管壁細胞ホスホリパーゼA_2の多様性と調節機構の解析Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
血小板に存在するアラキドン酸高親和性ホスホリパーゼA_2の生化学的解析Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokyo
Biological functions of mammalian non-pacreatic type Phospholipase A_2
- Principal Investigator
  
  INOUE Keizo
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tokyo
New assay systems for the development of inhibitory drugs against activated mast cell function
- Principal Investigator
  
  ICHIKAWA Atsushi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KYOTO UNIVERSITY
血管壁細胞ホスホリパ-ゼA_2の多様性と調節機構の解析Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
高等動物細胞II型ホスホリパ-ゼA_2活性制御Principal Investigator
- Principal Investigator
  
  工藤一郎
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  The University of Tokyo
Oxygen radical-induced tissue injuryPrincipal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  UNIVERSITY OF TOKYO
Inhibition of foam cell formation : Application to the discovery of novel antiatherosclerotic agents
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Kitasato Institute
トロンボスポンジンの係わる新しい血液凝固調節機構に関する研究
- Principal Investigator
  
  INOUE Keizo
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
新しい膜プロ-ブを用いたシナプス小胞膜融合機構の解析
- Principal Investigator
  
  梅田真郷
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
虚血心筋におけるPAFなどの脂質の変動メカニズム
- Principal Investigator
  
  井上圭三
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Biochemical Studies on Platelet Phospholipase A_2
- Principal Investigator
  
  INOUE Keizo
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokyo
Novel bioactions of platelet-activating factor (PAF)Principal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Effective Production of Monoclonal Antibodies Against Low Immunogenic Substances
- Principal Investigator
  
  INOUE Keizo
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
血管壁で産生されるPAFの動態と役割
- Principal Investigator
  
  井上圭三
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
虚血心筋におけるPAFなどの脂質の変動メカニズム
- Principal Investigator
  
  井上圭三
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Development and production of novel inhibitory protein for inflammatory phospholipase A2Principal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
アルキル結合を有するリン脂質の腫瘍選択的細胞毒性発現のメカニズム
- Principal Investigator
  
  井上圭三
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
血管壁で産生されるPAFの動態と役割
- Principal Investigator
  
  井上圭三
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
Development and application of new enzymatic method for quantification of platelet activation factor (PAF).Principal Investigator
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tokyo
Construction and application of cloning vector which carries signal sequence of Escherichia coli.
- Principal Investigator
  
  INOUE Keizo
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokyo
Anti-tumor activity of synthetic alkyllysophospholipids and glycolipidsPrincipal Investigator
- Principal Investigator
  
  KUDO Ichiro, 野島庄七
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

All 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Patent

[Journal Article] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders2008
- Author(s)
  Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H
- Journal Title
  
  Arthritis Rheum 58(1)
  
  Pages: 172-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Human group III secreted phospholipase A_2 promotes neuronal outgrowth and survival2008
- Author(s)
  Masuda S, Yamamoto K, Hirabayashi T, Ishikawa Y, Ishii T, Kudo I, Murakami M
- Journal Title
  
  Biochem. J. 409(2)
  
  Pages: 429-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Analyses of group III secreted phospholipase A_2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis2008
- Author(s)
  Sato H, Kato R, Isogai Y, Saka G, Ohtsuki M, Taketomi Y, Yamamoto K, Tsutsumi K, Yamada J, Masuda S, Ishikawa Y, Ishii T, Kobayashi T, Ikeda K, Taguchi R, Hatakeyama S, Hara S, Kudo I, Itabe H, Murakami M
- Journal Title
  
  J. Biol. Chem. 283(48)
  
  Pages: 33483-33497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Inhibitory effect of synthetic C-C biflavones on various phospholipase A_2s activity2007
- Author(s)
  Moon TC, Quan Z, Kim J, Kim HP, Kudo I, Murakami M, Park H, Chang HW
- Journal Title
  
  Bioorg. Med. Chem. 15(22)
  
  Pages: 7138-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] A novel role of group VIB calcium-independent phospholipase A_2(iPLA_2γ)in the inducible expression of group IIA secretory PLA_2 in rat fibroblastic cells2007
- Author(s)
  Kuwata H, Fujimoto C, Yoda E, Shimbara S, Nakatani Y, Hara S, Murakami M, Kudo I
- Journal Title
  
  J. Biol. Chem. 282(28)
  
  Pages: 20124-20132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Impaired mast cell maturation and degranulation and attenuated allergic responses in Ndrg1-deficient mice2007
- Author(s)
  Taketomi Y, Sunaga K, Tanaka S, Nakamura M, Arata S, Okuda T, Moon TC, Chang HW, Sugimoto Y, Kokame K, Miyata T, Murakami M, Kudo I
- Journal Title
  
  J. Immunol 178(11)
  
  Pages: 7042-7053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Knockout mice lacking cPGES/p23, a constitutively expressed PGE_2 synthetic enzyme, are peri-natally lethal2007
- Author(s)
  Nakatani Y, Hokonohara Y, Kakuta S, Sudo K, Iwakura Y, Kudo I
- Journal Title
  
  Biochem. Biophys. Res. Commun 362(2)
  
  Pages: 387-392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Human group III phospholipase A_2 suppresses adenovirus infection into host cells. Evidence that group III, V and X phospholipase A_2s act on distinct cellular phospholipid molecular species2007
- Author(s)
  Mitsuishi M, Masuda S, Kudo I, Murakami M
- Journal Title
  
  Biochim. Biophys. Acta 1771(11)
  
  Pages: 1389-1396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Prostaglandin E synthase : a novel drug target for inflammation and cancer.2006
- Author(s)
  Murakami M., Kudo I.
- Journal Title
  
  Curr Pharm Des. 12
  
  Pages: 943-954
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Unique membrane interaction mode of group IIF phospholipase A_22006
- Author(s)
  Wijewickrama GT, Albanese A, Kim YJ, Oh YS, Murray PS, Takayanagi R, Tobe T, Masuda S, Murakami M, Kudo I, Ucker DS, Murray D, Cho W
- Journal Title
  
  J. Biol. Chem. 281(43)
  
  Pages: 32741-32754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Transgenic expression of group V, but not group X, secreted phospholipase A_2 in mice leads to neonatal lethality because of lung dysfunction2006
- Author(s)
  Ohtsuki M, Taketomi Y, Arata S, Masuda S, Ishikawa Y, Ishii T, Takanezawa Y, Aoki J, Arai H, Yamamoto K, Kudo I, Murakami M
- Journal Title
  
  J. Biol. Chem. 281(47)
  
  Pages: 36420-36433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209004
[Journal Article] Group V and X secretory phospholipase A_2s prevent adenovirus infection into mammalian cells.2006
- Author(s)
  Mitsuishi, M., Masuda, S., Kudo, I., Murakami, M.
- Journal Title
  
  Biochem J. 393
  
  Pages: 97-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Searcu of factors that inermediate cytokine-indeced IIA Phospholipase A_2 expression through the cytosolic phospholipase A_2-and 12/(15)-lipoxygenase-dependent pathway2005
- Author(s)
  Kuwata, H., Nonaka, T., Murakami, M, Kudo, I
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 15830-25839
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Prostaglandin E synthase, a terminal enzyme for prostaglandin E_2 biosynthesis.2005
- Author(s)
  Kudo, I., Murakami, M.
- Journal Title
  
  J.Biochem.Mol.Biol. 38
  
  Pages: 633-638
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Expression of type V secretory phospholipase A_2 in myocardial remodeling after infarction.2005
- Author(s)
  Ishikawa, Y., Komiyama, I., Masuda, S., Murakami, M., Akasaka, Y., Ito, K., Akishima, Y., Kimura, M., Fujimoto, A., Kudo, I., Ishii, T.
- Journal Title
  
  Histopathology 47
  
  Pages: 257-267
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Expression of type phospholipase A_2 in myocardial remodelling after infaction.2005
- Author(s)
  Ishikawa, Y., Komiyama, K., Masuda, S., Murakami, M., Akasaka, Y., Ito, K., Akishima-Fukasawa, Y., Kimura, M., Fujimoto, A., Kudo, I., Ishii, T.
- Journal Title
  
  Histophathology 47
  
  Pages: 257-2678
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Expression of secretory phospholipase A_2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells2005
- Author(s)
  Masuda, S., Murakami, M., Mitsuishi, M., Komiyama, K., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  Biochem. J. 387
  
  Pages: 27-38
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A_22005
- Author(s)
  Murakami, M., Masuda, S., Shimbara, S., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  J.Biol.Chem 280
  
  Pages: 24987-24998
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Change in prostaglandin E synthases (PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model.2005
- Author(s)
  Kubota, K., Kubota, T., Kamei, D., Murakami, M., Kudo, I., Aso, T., Morita, I.
- Journal Title
  
  J.Endocrinol. 187
  
  Pages: 339-345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Diverse cellular localizations of secretory phospholipase A_2 enzymes in several human tissues.2005
- Author(s)
  Masuda, S., Murakami, M., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  Biochim.Biophys.Acta 1736
  
  Pages: 200-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Coupling between cyclooxygenases and terminal prostanoid synthases2005
- Author(s)
  Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I., Murakami, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 338
  
  Pages: 70-76
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A_22005
- Author(s)
  Murakami, M., Masuda, S., Shimbara, S., Isikawa, Y., Ishii, T., Kudo, I
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 24987-24998
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Search of factors that intermediate cytokine-induced group IIA phospholipase A_2 expression through the cytosolic phospholipase A_<2-> and 12/15-lipoxygenase-dependent pathway2005
- Author(s)
  Kuwata, H., Nonaka, T., Murakami, M., Kudo, I
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 25830-25839
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Various secretory phospholipase A_2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells2005
- Author(s)
  Masuda, S., Murakami, M., Komiyama, K., Ishihara, M., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  FEBS J. 272
  
  Pages: 655-672
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Coupling between cyclooxygenases and terminal prostanoid synthases.2005
- Author(s)
  Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I., Murakami, M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 338
  
  Pages: 70-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Group VIB Ca^<2+>-independent phospholipase A_2 (iPLA_γ) promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipase A_2s.2005
- Author(s)
  Murakami, M., Masuda, S., Ueda-Semmyo, K., Yoda, E., Kuwata, H., Takanezawa, Y., Aoki, J., Arai, H., Sumimoto, H., Ishikawa, Y., Ishii, T., Nakatani, Y., Kudo, I.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 14028-14041
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] ホスホリパーゼA_2研究の展開2005
- Author(s)
  村上誠, 工藤一郎
- Journal Title
  
  実験医学 23, No.6
  
  Pages: 878-885
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Change in prostaglandin E synthases(PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model.2005
- Author(s)
  Kubota, K., Kubota, T., Kamei, D., Murakami, M., Kudo, I., Aso, T., Morita, I.
- Journal Title
  
  J.Endocrinol. 187
  
  Pages: 339-345
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Expression of secretory phospholipase A_2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells2005
- Author(s)
  Masuda, S., Murakami, M., Mitsuishi, M., Komiyama, K., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  Biochem.J. 387
  
  Pages: 27-38
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Search of factors that intermediate cytokine-induced group IIA phospholipase A_2 expression through the cytosolic phospholipase A_2- and 12/15-lipoxygenase-dependent pathway.2005
- Author(s)
  Kuwata, H., Nonaka, T., Murakami, M., Kudo, I.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 25830-25839
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] ホスホリパーゼA2研究の展開2005
- Author(s)
  村上誠, 工藤一郎
- Journal Title
  
  実験医学 23
  
  Pages: 878-885
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Diverce cellular localixstion of phospholipase A_2 enzyme in several human tissues2005
- Author(s)
  Masuda, S., Murakami, M., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  Biochim.Biophys.Acta 1736
  
  Pages: 200-210
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Expression of secretory phospholipase A_2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells.2005
- Author(s)
  Masuda, S., Murakami, M., Mitsuishi, M., Komiyama, K., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  Biochem.J. 387
  
  Pages: 27-38
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Neuronal expression and neuritogenic action of group X secreted phospholipase A_2.2005
- Author(s)
  Masuda, S., Murakami, M., Takanezawa, Y., Aoki, J., Arai, H., Ishikawa, Y., Ishii, T., Arioka, M., Kudo, I.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 23203-23214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A_2.2005
- Author(s)
  Murakami, M., Masuda, S., Shimabara, S., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 24987-24998
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Various secretory phospholipase A_2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells.2005
- Author(s)
  Masuda, S., Murakami, M., Komiyama, K., Ishihara, M., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  FEBS J. 272
  
  Pages: 655-672
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Change in prostaglandin E synthases(PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model2005
- Author(s)
  Kubota, K., Kubota, T., Kamei, D., Murakami, M., Kudo, I., Aso, T., Morita, I.
- Journal Title
  
  Biochem.J. 187
  
  Pages: 339-3458
- Data Source
  KAKENHI-PROJECT-14207098
[Journal Article] Prostaglandin E synthase, a terminal enzyme for prostaglandin E_2 biosynthesis2005
- Author(s)
  Kudo, I., Murakami, M.
- Journal Title
  
  J. Biochem. Mol. Biol. 38
  
  Pages: 633-638
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Regulation of cytosolic prostaglandin E synthase by phosphorylation.2004
- Author(s)
  Kobayashi, T., Nakatani, Y., Tanioka, T.Tsujimoto, M, Nakajo, S., Nakaya, K., Murakami, M., Kudo, I.
- Journal Title
  
  Biochem.J. 381
  
  Pages: 59-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1.2004
- Author(s)
  Kamei, D., Yamakawa, K., Takegoshi, Y., Mikami-Nakanishi, M., Nakatani, Y., Oh-Ishi, S., Yasui, H., Azuma, Y., Hirasawa, N., Ohuchi, K., Kawaguchi, H., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Murakami, M., Kudo, I.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 33684-33695
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Contribution of membrane-associated prostaglandin E2 synthase (mPGES) to bone resorption.2003
- Author(s)
  Saegusa, M., Murakami, M., Nakatani, Y., Yamakawa, K., Katagiri, M., Matsuda, K., Nakamura, K., Kudo, I., Kawaguchi, H.
- Journal Title
  
  J.Cell Physiol. 197
  
  Pages: 348-356
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Regulatory functions of prostaglandin E_2 synthases2003
- Author(s)
  Kudo, I., Murakami, M.
- Journal Title
  
  Adv. Exp. Med. Biol. 525
  
  Pages: 103-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Recent advances in molecular biology and physiology of the prostaglandin E_2-biosynthetic pathway.2003
- Author(s)
  Murakami, M., Kudo, I.
- Journal Title
  
  Prog.Lipid.Res. 43
  
  Pages: 3-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Coupling between cyclooxygenases and prostaglandin F_<2α> synthase: detection of an inducible, glutathione-activated, membrane-bound prostaglandin F_<2α> -synthetic activity.2003
- Author(s)
  Nakashima, K., Ueno, N., Kamei, D., Tanioka, T., Nakatani, Y., Murakami, M., Kudo, I.
- Journal Title
  
  Biochim.Biophys.Acta 1633
  
  Pages: 96-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Regulatory functions of prostaglandin E_2 synthases2003
- Author(s)
  Kudo, I., Murakami, M.
- Journal Title
  
  Adv.Exp.Med.Biol. 525
  
  Pages: 103-106
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Recent advances in molecular biology and physiology of the prostaglandin E_2-biosynthetic pathway2003
- Author(s)
  Murakami, M., Kudo, I
- Journal Title
  
  Prog. Lipid. Res. 43
  
  Pages: 3-35
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.2003
- Author(s)
  Murakami, M., Nakashima, K., Kamei, K., Masuda, S., Ishikawa, Y., Ishii, T., Ohmiya, Y., Watanabe, K., Kudo, I.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 37937-37947
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Regulatory functions of prostaglandin E_2 synthases.2003
- Author(s)
  Kudo, I., Murakami, M.
- Journal Title
  
  Adv.Exp.Med.Biol. 525
  
  Pages: 103-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.2003
- Author(s)
  Kamei, D., Murakami, M., Nakatani, Y., Ishikawa, Y., Ishii, T., Kudo, I.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 19396-19405
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Journal Article] Regulation of cytosolic prostaglandin E_2 synthase by 90-kDa heat shock protein.2003
- Author(s)
  Tanioka, T., Nakatani, Y., Kobayashi, T., Tsujimoto, M., Oh-ishi, S., Murakami, M., Kudo, I.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 303
  
  Pages: 1018-1023
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390031
[Patent] Group III secretory phospholipase A_2(sPLA_2-III)for therapy and dianosis2005
- Inventor(s)
  Kudo, I., Murakami, M., Tsutsumi, K., Hatakeyama, S.
- Industrial Property Rights Holder
  Novartis Pharma
- Filing Date
  2005-10-19
- Data Source
  KAKENHI-PROJECT-14207098
[Patent] Group III secretory phospholipase A_2(sPLA_2-III) for therapy and diagnosis2005
- Inventor(s)
  Kudo, I, Murakami, M, Tsutsumi, K., Hatakeyama, S.
- Industrial Property Rights Holder
  Novartis Pharma
- Filing Date
  2005-10-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207098
[Presentation] 分泌性ホスホリパーゼA_2(sPLA_2)と生活習慣病との関連2009
- Author(s)
  磯貝有紀、佐藤弘泰、山本圭、武富芳隆、池田和貴、田口良、工藤一郎、小林哲幸、村上誠
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 二次リンパ組織特異的に発現しているIID型ホスホリパーゼA_2の解析2009
- Author(s)
  三木寿美、山本圭、多屋長治、工藤一郎、村上誠
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] II型分泌性ホスホリパーゼA_2の生体内機能の解析2008
- Author(s)
  佐藤弘泰、武富芳隆、山本圭、磯貝有紀、三木寿美、石川由起雄、石井壽晴、小林哲幸、原俊太郎、工藤一郎、村上誠
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  徳島
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] III型分泌性ホスホリパーゼA_2による血漿脂質の変化と動脈硬化の進展2008
- Author(s)
  坂豪一、加藤里奈、佐藤弘泰、村上誠、工藤一郎、板部洋之
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] Search of bioactive lipid(s)that participates in the regulation of group IIA phospholipase A2 expressions in cytokine-stimulated rat fibroblasts.2008
- Author(s)
  桑田浩, 工藤一郎
- Organizer
  2008 FASEB Summer Research Conferences -Phospholipid Metabolism ; disease, signal transduction and membrane dynamics
- Place of Presentation
  New Haven, Connecticut, USA
- Year and Date
  2008-07-21
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] Group III PLA_2 is a critical regulator of mast cell differentiation and activation2008
- Author(s)
  武富芳隆、佐藤弘泰、川名桃子、田中智之、上野紀子、山本圭、荒田悟、原俊太郎、工藤一郎、村上誠
- Organizer
  2008 FASEB Summer Research Conferences-Phospholipid Metabolism : disease, signal transduction and membrane dynamics
- Place of Presentation
  アメリカ・ニューヘブン
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型Ca^<2+>非依存性ホスホリパーゼA_2(iPLA_2γ)の細胞内機能解析、BMB(Biochemistry and Molecular Biology)20082008
- Author(s)
  鉢須桂子、依田恵美子、桑田浩、中谷良人、原俊太郎、工藤一郎
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型カルシウム非依存性ホスホリパーゼA_2(iPLA_2γ)の機能解析2008
- Author(s)
  依田恵美子、鉢須桂子、武富芳隆、桑田浩、中谷良人、原俊太郎、工藤一郎
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 二次リンパ組織特異的に発現しているIID型ホスホリパーゼA_2の解析、BMB(Biochemistry and Molecular Biology)20082008
- Author(s)
  三木寿美、山本圭、多屋長治、工藤一郎、村上誠
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] Diverse functions of sPLA_2s : from cells to transgenics and knockouts2008
- Author(s)
  村上誠、工藤一郎
- Organizer
  2008 FASEB Summer Research Conferences - Phospholipid Metabolism : disease, signal transduction and membrane dynamics
- Place of Presentation
  アメリカ・ニューヘブン
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] マスト細胞におけるIII型分泌性ホスホリパーゼA_2の機能解析、BMB(Biochemistry and Molecular Biology)20082008
- Author(s)
  川名桃子、武富芳隆、片柳香菜恵、佐藤弘泰、工藤一郎、村上誠、原俊太郎
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] マスト細胞におけるIII型分泌性ホスホリパーゼA_2の機能解析2008
- Author(s)
  川名桃子、武富芳隆、佐藤弘泰、工藤一郎、村上誠、原俊太郎
- Organizer
  第52回日本薬学会関東支部大会
- Place of Presentation
  野田
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] II型分泌性ホスホリパーゼA_2は即時性アレルギーに関与する2008
- Author(s)
  武富芳隆、川名桃子、佐藤弘泰、田中智之、上野紀子、山本圭、荒田悟、原俊太郎、工藤一郎、村上誠
- Organizer
  第9回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 分泌性ホスホリパーゼA_2の皮膚および体毛分化における役割2008
- Author(s)
  山本圭、三木寿美、磯貝有紀、池田和貴、中西広樹、武富芳隆、田口良、工藤一郎、小林哲幸、村上誠
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  徳島
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型カルシウム非依存性ホスホリパーゼA_2(iPLA_2γ)の機能解析2008
- Author(s)
  依田恵美子、鉢須桂子、武富芳隆、中谷良人、原俊太郎、工藤一郎
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  徳島
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型カルシウム非依存性ホスホリパーゼA_2(iPLA_2γ)の細胞内機能解析2008
- Author(s)
  鉢須桂子、依田恵美子、小林裕司、桑田浩、中谷良人、原俊太郎、工藤一郎
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] III型分泌性ホスホリパーゼA_2は即時型アレルギーに関与する、BMB(Biochemistry and Molecular Biology)20082008
- Author(s)
  武富芳隆、川名桃子、佐藤弘泰、田中智之、山本圭、荒田悟、原俊太郎、工藤一郎、村上誠
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] Skin abnormalities of group X secretory phospholipase A_2 transgenic mice2008
- Author(s)
  山本圭、三木寿美、武富芳隆、池田和貴、中西広樹、田口良、工藤一郎、村上誠
- Organizer
  2008 FASEB Summer Research Conferences-Phospholipid Metabolism : disease, signal transduction and membrane dynamics
- Place of Presentation
  アメリカ・ニューヘブン
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] III型分泌性ホスホリパーゼA_2の雄性生殖における役割、BMB(Biochemistry and Molecular Biology)20082008
- Author(s)
  佐藤弘泰、武富芳隆、山本圭、磯貝有紀、石川由紀雄、石井壽晴、小林哲幸、原俊太郎、工藤一郎、村上誠
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] マウス精子の分泌性ホスホリパーゼA_2の受精反応における機能解析2008
- Author(s)
  種本明生、武富芳隆、加藤洋幸、新原智子、村上誠、原俊太郎、工藤一郎
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型Ca^<2+>非依存性ホスホリパーゼA_2(iPLA_2γ)の生体内機能の解析、BMB(Biochemistry and Molecular Biology)20082008
- Author(s)
  依田恵美子、鉢須桂子、武富芳隆、中谷良人、原俊太郎、工藤一郎
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] X型およびIIF型分泌性ホスホリパーゼA_2の皮膚および体毛分化における役割、BMB(Biochemistry and Molecular Biology)20082008
- Author(s)
  山本圭、武富芳隆、三木寿美、池田和貴、中西広樹、田口良、工藤一郎、村上誠
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] III型分泌性ホスホリパーゼA_2はリポタンパクの変性を介して動脈硬化を増悪する2008
- Author(s)
  加藤里奈、坂豪一、佐藤弘泰、村上誠、工藤一郎、板部洋之
- Organizer
  第9回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 分泌性ホスホリパーゼA_2(sPLA_2)と生活習慣病との関連、BMB(Biochemistry and Molecular Biology)20082008
- Author(s)
  磯貝有紀、佐藤弘泰、山本圭、武富芳隆、池田和貴、田口良、工藤一郎、小林哲幸、村上誠
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 受精段階における精子の分泌性ホスホリパーゼA_2の機能解析、BMB(Biochemistry and Molecular Biology)20072007
- Author(s)
  種本明生、武富芳隆、村上誠、原俊太郎、工藤一郎
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型Ca^<2+>非依存性ホスホリパーゼA_2(iPLA_2γ)の細胞周期への関与の検討、BMB(Biochemistry and Molecular Biology)20072007
- Author(s)
  鉢須桂子、依田恵美子、小林裕司、藤本知佳子、桑田浩、中谷良人、原俊太郎、工藤一郎
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 皮膚および体毛分化における分泌性ホスホリパーゼA_2の役割、BMB(Biochemistry and Molecular Biology)20072007
- Author(s)
  山本圭、三木寿美、池田和貴、益田聖子、武富芳隆、石本義和、花崎浩二、田口良、工藤一郎、村上誠
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] III型分泌性ホスホリパーゼA_2の雄性生殖における役割、BMB(Biochemistry and Molecular Biology)20072007
- Author(s)
  佐藤弘泰、武富芳隆、山本圭、磯貝有紀、石川由起雄、石井壽晴、小林哲幸、原俊太郎、工藤一郎、村上誠
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] Analyses of abnormal skin in group X secretory phospholipase A_2-transgenic mice2007
- Author(s)
  山本圭、益田聖子、武富芳隆、田口良、工藤一郎、村上誠
- Organizer
  3rd International Conference on Phospholipase A_2 and Lipid Mediators
- Place of Presentation
  イタリア・ソレント
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型カルシウム非依存性ホスホリパーゼA_2の機能解析-感染防御への関与-2007
- Author(s)
  依田恵美子、藤本知佳子、小林裕司、桑田浩、中谷良人、原俊太郎、工藤一郎
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-30
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型ホスホリパーゼA_2(iPLA_2γ)の生体内機能の解析、BMB(Biochemistry and Molecular Biology)20072007
- Author(s)
  依田恵美子、鉢須桂子、武富芳隆、荒田悟、中谷良人、原俊太郎、工藤一郎
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] Biological actions of group III phospholipase A_2, an atypical sPLA_2, in vivo2007
- Author(s)
  佐藤弘泰、磯貝有紀、武富芳隆、山本圭、工藤一郎、村上誠
- Organizer
  10th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
- Place of Presentation
  カナダ・モントリオール
- Year and Date
  2007-09-17
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型Ca^<2+>非依存性ホスホリパーゼA_2(iPLA_2γ)の解析2007
- Author(s)
  依田恵美子、小林裕司、藤本知佳子、桑田浩、武富芳隆、荒田悟、中谷良人、原俊太郎、工藤一郎
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  札幌
- Year and Date
  2007-06-06
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 新たな内分泌攪乱作用の標的としての精子ホスホリパーゼA_2の解析、フォーラム20072007
- Author(s)
  種本明生、武富芳隆、原俊太郎、工藤一郎
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  大阪
- Year and Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] III型分泌性ホスホリパーゼA_2(sPLA_2)と生活習慣病との関連、BMB(Biochemistry and Molecular Biology)20072007
- Author(s)
  磯貝有紀、山本圭、佐藤弘泰、武富芳隆、池田和貴、田口良、工藤一郎、小林哲幸、村上誠
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] X型分泌性ホスホリパーゼA_2トランスジェニックマウスの皮膚異常の解析2007
- Author(s)
  山本圭、益田聖子、武富芳隆、田口良、工藤一郎、村上誠
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  札幌
- Year and Date
  2007-06-06
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 分泌性ホスホリパーゼA_2の神経系における発現と機能2006
- Author(s)
  益田聖子、武富芳隆、大槻光浩、山本圭、平林哲也、石川由紀雄、石井壽晴、石本義和、花崎浩二、村上誠、工藤一郎
- Organizer
  ファーマ・バイオフォーラム2006
- Place of Presentation
  東京
- Year and Date
  2006-12-09
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] III型分泌性ホスホリパーゼA_2トランスジェニックマウスの解析、フォーラム20062006
- Author(s)
  佐藤弘泰、武富芳隆、大槻光浩、石川由紀雄、石井壽晴、平林哲也、山本圭、磯貝有紀、上野紀子、益田聖子、村上誠、工藤一郎
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2006-10-30
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] Group X secretory phospholipase A2-transgenic mice exhibit alopecia during first hair cycle2006
- Author(s)
  山本圭、益田聖子、武富芳隆、工藤一郎、村上誠
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress・第79回日本生化学会大会・第29回日本分子生物学会年会
- Place of Presentation
  京都
- Year and Date
  2006-02-01
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] 膜結合型カルシウム非依存性ホスホリパーゼA_2(iPLA_2γ)の機能解析2006
- Author(s)
  依田恵美子、桑田浩、藤本知佳子、中谷良人、原俊太郎、工藤一郎
- Organizer
  ファーマ・バイオフォーラム2006
- Place of Presentation
  東京
- Year and Date
  2006-12-09
- Data Source
  KAKENHI-PROJECT-18209004
[Presentation] III型分泌性ホスホリパーゼA_2の生体機能2006
- Author(s)
  佐藤弘泰、武富芳隆、加藤里奈、石川由紀雄、石井壽晴、板部洋之、原俊太郎、村上誠、工藤一郎
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  東京
- Year and Date
  2006-06-08
- Data Source
  KAKENHI-PROJECT-18209004

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KUDO Ichiro 工藤 一郎

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Functional analysis of phospholipase A2 by genetically modified mice and its biopharmaceutical applicationPrincipal Investigator

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アラキドン酸代謝反応の異常亢進により惹起される細胞の癌性変化の解析Principal Investigator

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新しい視点に立った内分泌攪乱物質の毒性発現メカニズムの解析Principal Investigator

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Analyses of phospholipase A_2 enzymes that are involved in signaling and non-signaling eventsPrincipal Investigator

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哺乳動物細胞の核画分に存在する新しいアラキドン酸カスケード制御因子の検索Principal Investigator

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高等動物ホスホリパーゼA_2の機能、発現、動態の総合評価Principal Investigator

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Analysis of prostaglandin E2 synthasesPrincipal Investigator

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カルシウム依存性ホスホリパーゼA_2(PLA_2)と相互作用する細胞因子の研究Principal Investigator

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ヒ素含有グリセロリン脂質の解析に基づいたヒ素の毒性発現メカニズムの衛生薬学的研究Principal Investigator

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KUDO Ichiro 工藤一郎