Omura Satoshi 大村智

… Alternative Names

SATOSHI Omura 大村智

OMURA Satoshi 大村智

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Researcher Number	90050426
Other IDs
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Affiliation (Current)	2025: 北里大学, 大村智記念研究所, 名誉教授
Affiliation (based on the past Project Information) *help	2008: 北里生命科学研究所, 名誉教授 2001 – 2002: 北里大学, 北里生命科学研究所, 教授 2001: 北里大学, 北里研究所, 所長 2000: 北里研究所, 所長 1999 – 2000: 社団法人北里研究所, 生物機能研究所, 所長 … More 1996 – 1998: 北里研究所, 所長 1997: 北里大学, 北里研究所, 所長 1995 – 1997: 社団法人北里研究所, 生物機能研究所, 所長 1996: (社)北里研究所, 生物機能研究所, 所長 1990 – 1992: 北里研究所, 所長 1987 – 1989: 北里大学, 北里研究所, 副所長 1987: The Kitasato Institute,Vice President., 副所長 1986: 北里研, その他, その他 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Chemical pharmacy Except Principal Investigator Chemical pharmacy / Morphological basic dentistry
Keywords	Principal Investigator ACAT / 阻害剤 / Inhibitor / 誘導体合成 / ピリピロペン / Cloning / Bifunctional cosmid / シャトルコスミド / 抗生物質 / クローニング … More / シヤトルコスミド / synthesis of derivatives / marine products / elucidation of structure / purification of active compounds / plant resource / microbial resource / chemistry of natural products / antimalarial drugs / 海洋生物素材 / 活性物質の構造決定 / 活性物質の精製 / 植物素材 / 微生物素材 / 天然物化学 / 抗マラリア剤 / Andrastin / Ras protein / Acly-Coa synthetase / Triacsin / HIV Gag protein / Farnesyltransferase / Myristoylation / 抗エイズ剤 / アシル化 / 脂質修飾蛋白質 / 抗癌剤 / 抗エイズ薬 / アンドラスチン / Ras蛋白質 / アシルCoA合成酵素 / トリアクシン / HIV Gag蛋白質 / ファルネシル化 / ミリストイル化 / Biosynthesis / Total synthesis / Structure-activity relationship / Pyripyropene / Fungal metabolite / Acyl-CoA : cholesterol acyltransferase / アシルCoA:コレステロールアシル転移酵素 / 全合成 / アシルCoA:コレスチロールアシル転移酵素 / コレステロール代謝 / CETP / コレステリルエステル転送蛋白質 / コレステロール代謝阻害剤 / 生合成 / 金合成 / 構造活性相関 / カビ代謝産物 / アシルCoAコレステロールアシル転移酵素 / cholesterol transport / cholesterol / steroid / azole / ACAT inhibitor / foam cell / macrophage / 細胞内輸送 / コレステロ-ル / パ-パクチン / 抗真菌剤 / シクロデプシペプチド / マクロファ-ジ / グリソプレニン / コレステロール輸送 / コレステロール / ステロイド系阻害剤 / アゾール系抗真菌剤 / ACAT阻害剤 / 泡沫化 / マクロファージ … More Except Principal Investigator 全合成 / ピリピロペン / α-ピロン / アリスガシン / 不斉合成 / 立体選択的 / メロ-テルペノイド / ACAT / IL-6 / メローテルペノイド / カップリング / AChE / 酵素阻害剤 / 蛋白質生産 / 微生物の探索 / Structor Determination / Absolute Stereochemistry / Enantioselective / Stereoselectire / Ligand / Madindoline / Natunal Products / 鍵化学物質 / 生物活性天然物 / エナンチオ制御 / 効率的 / 絶対構造決定 / 生物活性 / 大量合成 / リガンド / エナンチオ選択的 / 短工程 / 不斉リガンド / インターロイキン6 / マジンドリン / 微量天然物 / Structure-Activity Relationships / biomimetic / sesquiterpene / Coupling reaction / Total Synthesis / Meroterpenoid / alpha-Pyrone / アリスカシン / メロ-テルぺノイド / セスキテルペン / AchE / 増殖制御物質 / グリオキサール / 代謝拮抗剤 / 酸性プロテアーゼ / ピロロキノリンキノン生産 / 酵母の巨大化 / メチルグリオキサール / コレストロール合成阻害剤 / プロテアーゼ阻害剤 / 解糖系酵素の阻害剤 / 有用蛋白質の生産 / 有用微生物の探索 / 酸化ストレス / Aggregatibacter actinomycetemcomitans / 若年性歯周炎 / 毒素 / 限局性侵襲性歯周炎 / ペルオキシダーゼ / 呼吸鎖 / アリヌガシン / 化学変換 / ピロロキノリンキノン / Sーラクトイルグルタチオン / 遺伝子工学 Less

The physiological role of the respiratory chain-dependent peroxidase that is discovered from Aggregatibacter actinomycetemcomitans.
- Principal Investigator
  
  TAKASHIMA Eizo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  The Nippon Dental University
Efficient Enantioselectine Total Synthesis of Bioactiae natual Products
- Principal Investigator
  
  SUNAZAKA Toshiahi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Research of the antimalarial drugs from the natural productsPrincipal Investigator
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
  Kitasato Institute
多官能性α-ピロン環を有するメロ-テルペノイド類の立体選択的合成研究
- Principal Investigator
  
  SUNAZUKA Toshiaki
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
多官能性α-ピロン環を有するメロ-テルペノイド類の立体選択的合成研究
- Principal Investigator
  
  砂塚敏明
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
多官能性α-ピロン環を有するメローテルペノイド類の立体選択的合成研究
- Principal Investigator
  
  砂塚敏明
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kitasato University
Chemical Studies of alpha-Pyrone Meroterpenoids
- Principal Investigator
  
  SUNAZUKA Toshiaki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Studies on fungal pyripyropenes, potent inhibitors of cholesterol metabolismPrincipal Investigator
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The Kitasato Institute
Studies on the cellular functions of lipid-modified proteinsPrincipal Investigator
- Principal Investigator
  
  OHMURA Satoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Kitasato Institute
Inhibition of foam cell formation : Application to the discovery of novel antiatherosclerotic agentsPrincipal Investigator
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Kitasato Institute
新しい微生物探索系の理論的構築
- Principal Investigator
  
  鵜高重三
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
新しい微生物探索系の理論的構築
- Principal Investigator
  
  鵜高重三
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
新しい微生物探索系の理論的構築
- Principal Investigator
  
  鵜高重三
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
Construction of Streptomyces-Eschetichia coli bifunctional cosmid and cloning of antibiotic biosynthetic genes.Principal Investigator
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Kitasato Insitute

All 2003 2002 2001 2000

All Journal Article

[Journal Article] Total Synthesis of the AchE Inhibitors (±)-Arisugacins F and G2003
- Author(s)
  Handa, M., Sunazuka, T., Sugawara, M., Harigaya, Y., Omura, S.
- Journal Title
  
  J.Antibiot. 56
  
  Pages: 725-726
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12672061
[Journal Article] A Short Total Synthesis of (+)-Madindoline A and B2002
- Author(s)
  Sunazuka, T., Hirose, T., Shirahata, T., Yamamoto, D., Harigaya, Y., Kuwajima, I., Omura., S.
- Journal Title
  
  Organic Letters. 4
  
  Pages: 501-503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12672061
[Journal Article] The First Total Synthesis of (±)Arisugacin A, A Potent, Orally Inhibitor of Acetylcholinesterase2002
- Author(s)
  Sunazuka, T., Handa, M., Nagai, K., Shirahata, T., Otoguro, K., Harigaya, Y., Kuwajima, I., Omura, S.
- Journal Title
  
  Organic Letters. 4
  
  Pages: 367-369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12672061
[Journal Article] Convergent Synthesis of Arisugacin Skekleton and Their Acetylcholinesterase Inhibitor2001
- Author(s)
  Sunazuka, T., Handa, M., Nagai, K., Kimura, R., Shirahata, T., Tian, Z-M., Otoguro, K., Harigaya, Y., Omura, S.
- Journal Title
  
  J.Antibiotics. 54
  
  Pages: 382-385
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12672061
[Journal Article] Total Synthesis of (+)-Madindoline A and (-)-Madindoline B, Potent Inhibitors of Interleukin 62000
- Author(s)
  Sunazuka, T., Hirose, T., Shirahata, T., Harigaya, Y., Hayashi, M., Komiyama, K., Omura, S.
- Journal Title
  
  J.Am.Chem.Soc. 122
  
  Pages: 2122-2123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12672061
[Journal Article] Arisugacins C and D, Novel Acetylcholinesterase inhibitors and Their Related Novel Matabolites2000
- Author(s)
  Otoguro, K., Sunazuka, T., Omura, S.
- Journal Title
  
  J.Antibiotics 53
  
  Pages: 52-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12672061

1. SUNAZUKA Toshiaki (30226592)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
2. TOMODA Hiroshi (70164043)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 鵜高重三 (70023463)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 木村光 (80026541)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 村尾澤夫 (00081472)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 遠藤章 (60126290)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KAZURO Shiomi (40235502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. ARAI Hiroyuki (40167987)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 飴山實 (90022053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TAKASHIMA Eizo (50366762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KONISHI Kiyoshi (20178289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KUDO Ichiro (30134612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OBATA Rika (20260078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TABATA Noriko (60260080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MASUMA Rokuro (90219353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MORIKAWA Yuko (20191017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. INOKOSHI Junji (30151640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OTOGURO Kazuhiko (80118794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMADA Haruki (60096691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. UI Hideaki (90290957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KIYOHARA Hiroaki (70161601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. IKEDA Haruo (90159632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 奥田重信 (30013296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 林正彦 (20164965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 田中晴雄 (40118823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Omura Satoshi 大村 智

SATOSHI Omura 大村 智

OMURA Satoshi 大村 智

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Research of the antimalarial drugs from the natural productsPrincipal Investigator

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Studies on fungal pyripyropenes, potent inhibitors of cholesterol metabolismPrincipal Investigator

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Research Institution

Studies on the cellular functions of lipid-modified proteinsPrincipal Investigator

Principal Investigator

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Research Institution

Inhibition of foam cell formation : Application to the discovery of novel antiatherosclerotic agentsPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Principal Investigator

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Research Institution

Principal Investigator

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Research Institution

Construction of Streptomyces-Eschetichia coli bifunctional cosmid and cloning of antibiotic biosynthetic genes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Total Synthesis of the AchE Inhibitors (±)-Arisugacins F and G2003

Author(s)

Journal Title

Description

Data Source

Omura Satoshi 大村智

SATOSHI Omura 大村智

OMURA Satoshi 大村智