HAYASHI Masahiko 林正彦

… Alternative Names

林正彦ハヤシマサヒコ

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Researcher Number	20164965
Other IDs
Affiliation (based on the past Project Information) *help	2010: いわき明星大学, 薬学部・薬学科, 教授 2008 – 2009: いわき明星大学, 薬学部, 教授 2007 – 2008: いわき明星大学, 薬学科, 教授 2006: 北里研究所, 生命科学研究所実験動物管理室, 助教授 2004: 北里大学, 北里生命科学研究所, 助教授 … More 2003: 北里大学, 生命科学研究所, 助教授 2001 – 2002: 北里大学, 北里生命科学研究所, 助教授 2000: 社団法人北里研究所, 基礎研究所, 室長 1999: 北里研究所, 基礎研究所, 室長 1999: 社団法人北里研究所, 基礎研究所, 室長 1996 – 1997: (社)北里研究所, 基礎研究所, 室長 1988 – 1989: 北里大学, 薬学部, 講師 1987: 北里大学, 薬学部・薬理学教室, 講師 Less
Review Section/Research Field	Principal Investigator Science and Engineering Except Principal Investigator Biological Sciences / Applied pharmacology / Drug development chemistry / Chemical pharmacy / Biological pharmacy
Keywords	Principal Investigator 多剤耐性 / 耐性克服 / [^3H]-azidopine / PR-69 / P388 / VCR / KB / VJ300 / photolabeling / [^3H]-VCR … More Except Principal Investigator … More TRAIL / Leukemia(白血病) / apoptosis(アポトーシス) / adhesion(接着) / チロシンキナーゼ / 抗生物質(antibiotics) / レチノイン酸(retinoic acid) / テロメラーゼ阻害剤 / 海洋生物由来細胞毒物質 / 細胞接着阻害剤 / 血管新生阻害剤 / 神経突起伸長 / アポトーシス誘導物質 / 細胞接着阻害物質 / 細胞周期阻害物質 / PP2A / 微小管重合 / caspase-3 / DNAポリメラーゼβ阻害物質 / チロシンキナーゼ阻害物質 / 多剤耐性克服物質 / IL-6阻害物質 / TGF-β活性調節物質 / サイトカイン調節物質 / 消化管毒性軽減物質 / 細胞接着阻害 / macrosphelide / 血管新生阻害 / Str.TI / B16 / BL6 melanoma / 肺転移 / SLe^x / E-selectin / VEGF / IL-6阻害 / QOL / 多剤耐性克服 / FO-7711 / CD4 / CD6 / P-glycoprotein / MH60 / 薬剤耐性 / 癌性悪液質 / IL-6 / がん / 多剤耐性 / がん悪液質 / 耐性克服 / がん性悪疫質 / センソ / 天然物 / 悪液質 / インドールアルカロイド / イソプレノイド / ブフォゲニン / 分子標的治療 / アポトーシス / 成人T細胞白血病・リンパ腫 / 分子標的薬 / 天然由来物質 / 天然物質 / 分子標的治療薬 / 微生物二次代謝産物 / HIF-1α / 低酸素 / 乳がん / 血管内皮増殖因子 / 非相同組換え / 染色体再編成 / DNA二本鎖切断 / DNAエンドジョイニング / DNAジャイレース / RecQヘリケース / RecFORタンパク質 / Sgs1ヘリケース / 非相同的組換え / DNA二重鎖切断 / 増殖静止期 / 飢餓 / DNAアルキル化 / adaptive mutation / adaptive amplification / RecEエキソヌクレアーゼ / H-NSタンパク質 / Tag DNAグリコシラーゼ / DNAトポイソメラーゼII / WRNヘリケース / DnaBヘリケース / DNA損傷 / DNAリガーゼ / 遺伝的組換え / サイレンシング因子 / 修復 / 組換え / Ku蛋白質 / DNAヘリケース / 老化 / SGSI遺伝子 / DNAヘリカーゼ / BLM遺伝子 / WRN遺伝子 / DNA損傷のチェックポイント / Chromosomal aberration / DNA double-strand break / DNA end-joining / Illegitimate recombination / DNA gyrase / RecQ helicase / RecROF proteins / Sgsl helicase / 抗マラリア剤 / 天然物化学 / 微生物素材 / 植物素材 / 活性物質の精製 / 活性物質の構造決定 / 海洋生物素材 / 誘導体合成 / antimalarial drugs / chemistry of natural products / microbial resource / plant resource / purification of active compounds / elucidation of structure / marine products / synthesis of derivatives / キニノゲン欠損ラット / 高分子キニノゲン / T-キニノゲン / カラゲニン胸膜炎 / 炎症反応 / アラキドン酸代謝物 / 低分子キニノゲン / ラジオイムノアッセイ / Tーキニノゲン / 急性相蛋白質 / 性差 / カリクレイン・キニン系 / ブラジキニン / カプトプリル / カラゲニン足浮腫 / HMW-kininogen / LMW-kininogen / T-kininogen / Inflammation / Rat pleurisy / Kininogen-deficient rat / Eicosanoids / Radioimmunoassay Less

Search on molecular target cancer drug from microbial secondary metabolites
- Principal Investigator
  
  KIM Yongpil
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Iwaki Meisei University
Natural compounds that enhance TRAIL-induced apoptosis : a novel molecular targeted cancer therapy
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Nagasaki University
天然由来鍵化合物の探索と病態解析への応用Principal Investigator
- Principal Investigator
  
  林正彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Kitasato Institute
天然由来抗腫瘍性物質の開拓と病態解析への応用
- Principal Investigator
  
  小宮山寛機
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato Institute
天然より得られた抗腫瘍物質の作用機序解析と実験病態モデルでの評価
- Principal Investigator
  
  小宮山寛機
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato Institute
新規天然制癌物質の探索とその作用機序の解明
- Principal Investigator
  
  石塚雅章
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Microbial Chemistry Research Foundation
天然物由来癌転移抑制物質の研究
- Principal Investigator
  
  小宮山寛機
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kitasato Institute
Research of the antimalarial drugs from the natural products
- Principal Investigator
  
  OMURA Satoshi
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
  Kitasato Institute
Mechanisms of recombination mediated by DNA end-joining
- Principal Investigator
  
  OGATA Yasuyuki, IKEDA Hideo
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Genetics
  Kitasato Institute
  The University of Tokyo
白血病細胞のアポトーシス誘導ならびに浸潤阻止のための制御技術と天然薬物の開発
- Principal Investigator
  
  片桐拓也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato Institute
Biological role of kininogens; Studies using kininogen deficient rats.
- Principal Investigator
  
  OH-ISHI Sachiko
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University, School of Pharm.Sci.

All 2011 2010 2009 2007 2004

All Journal Article Presentation Book

[Book] 「Interleukin-6阻害物質と病態への応用」、血液・腫瘍科2004
- Author(s)
  林正彦
- Total Pages
  10
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-13218140
[Journal Article] TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina.2009
- Author(s)
  M. Ozawa, T. Etoh, M. Hayashi, K. Komiyama, A. Kishida, A. Ohsaki
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Pages: 234-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590107
[Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production2007
- Author(s)
  長谷川寛雄, 山田恭暉, 小宮山寛機, 林正彦, 石橋正巳, 砂塚敏明, 菅原和行, 鶴田一人, 増田昌人, 高須信行, 塚崎邦弘, 朝長万左男, 上平憲
- Journal Title
  
  Blood 110(5)
  
  Pages: 1664-74
- Data Source
  KAKENHI-PROJECT-18590510
[Presentation] 低酸素下HIF-1αの細胞内蓄積抑制作用を有する化合物の作用機序2011
- Author(s)
  金容必、関寧、江藤忠洋、林正彦、田中晴雄
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590107
[Presentation] TLRシグナル伝達阻害物質berkeleyacetal Cの標的分子の解明2010
- Author(s)
  江藤忠洋、金容必、田中晴雄、林正彦
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590107
[Presentation] 土壌糸状菌由来chaetochromin類の低酸素応答性転写因子HIF-1に対する作用2010
- Author(s)
  関寧、金容必、江藤忠洋、林正彦、田中晴雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590107
[Presentation] 土壌由来糸状菌の生産する抗炎症物質berkeleyacetal Cの作用機序に関する研究2009
- Author(s)
  江藤忠洋、金容必、田中晴雄、林正彦
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590107

1. 小宮山寛機 (00106676)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. 深海明子 (60300745)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TOMODA Hiroshi (70164043)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OGATA Yasuyuki (90344449)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. IKEDA Hideo (10012775)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HASEGAWA Hiroo (00398166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KIM Yongpil (70337997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. NIKI Hironori (70208122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OMURA Satoshi (90050426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OTOGURO Kazuhiko (80118794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMADA Haruki (60096691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. UI Hideaki (90290957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KIYOHARA Hiroaki (70161601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OH-ISHI Sachiko (70050416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. UTSUNOMIYA Iku (70168722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YAMAKI Kohji (70174597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HAYASHI Izumi (90172999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 片桐拓也 (70126100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 塚本俊彦 (10236862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 石塚雅章 (80159722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 上村大輔 (00022731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 伏谷伸宏 (70012010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 瀬戸治男 (10013335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 長田裕之 (80160836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 小林淳一 (90221241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 浅沼史樹 (40129309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 山田恭暉 (60145232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 上平憲 (80108290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. 舘林和夫 (50272498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 加藤潤一 (10194820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 塩見和朗 (40235502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 彌益暁子 (80174697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. KANN Toh?Seok

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAYASHI Masahiko 林 正彦

林 正彦 ハヤシ マサヒコ

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[Book] 「Interleukin-6阻害物質と病態への応用」、血液・腫瘍科2004

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Total Pages

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Data Source

[Journal Article] TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina.2009

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Data Source

[Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production2007

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Data Source

[Presentation] 低酸素下HIF-1αの細胞内蓄積抑制作用を有する化合物の作用機序2011

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Data Source

[Presentation] TLRシグナル伝達阻害物質berkeleyacetal Cの標的分子の解明2010

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HAYASHI Masahiko 林正彦

林正彦ハヤシマサヒコ