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HAYASHI Masahiko  林 正彦

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… Alternative Names

林 正彦  ハヤシ マサヒコ

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Researcher Number 20164965
Other IDs
Affiliation (based on the past Project Information) *help 2010: いわき明星大学, 薬学部・薬学科, 教授
2008 – 2009: いわき明星大学, 薬学部, 教授
2007 – 2008: いわき明星大学, 薬学科, 教授
2006: 北里研究所, 生命科学研究所実験動物管理室, 助教授
2004: 北里大学, 北里生命科学研究所, 助教授 … More
2003: 北里大学, 生命科学研究所, 助教授
2001 – 2002: 北里大学, 北里生命科学研究所, 助教授
2000: 社団法人北里研究所, 基礎研究所, 室長
1999: 北里研究所, 基礎研究所, 室長
1999: 社団法人 北里研究所, 基礎研究所, 室長
1996 – 1997: (社)北里研究所, 基礎研究所, 室長
1988 – 1989: 北里大学, 薬学部, 講師
1987: 北里大学, 薬学部・薬理学教室, 講師 Less
Review Section/Research Field
Principal Investigator
Science and Engineering
Except Principal Investigator
Biological Sciences / Applied pharmacology / Drug development chemistry / Chemical pharmacy / Biological pharmacy
Keywords
Principal Investigator
多剤耐性 / 耐性克服 / [^3H]-azidopine / PR-69 / P388 / VCR / KB / VJ300 / photolabeling / [^3H]-VCR … More
Except Principal Investigator
… More TRAIL / Leukemia(白血病) / apoptosis(アポトーシス) / adhesion(接着) / チロシンキナーゼ / 抗生物質(antibiotics) / レチノイン酸(retinoic acid) / テロメラーゼ阻害剤 / 海洋生物由来細胞毒物質 / 細胞接着阻害剤 / 血管新生阻害剤 / 神経突起伸長 / アポトーシス誘導物質 / 細胞接着阻害物質 / 細胞周期阻害物質 / PP2A / 微小管重合 / caspase-3 / DNAポリメラーゼβ阻害物質 / チロシンキナーゼ阻害物質 / 多剤耐性克服物質 / IL-6阻害物質 / TGF-β活性調節物質 / サイトカイン調節物質 / 消化管毒性軽減物質 / 細胞接着阻害 / macrosphelide / 血管新生阻害 / Str.TI / B16 / BL6 melanoma / 肺転移 / SLe^x / E-selectin / VEGF / IL-6阻害 / QOL / 多剤耐性克服 / FO-7711 / CD4 / CD6 / P-glycoprotein / MH60 / 薬剤耐性 / 癌性悪液質 / IL-6 / がん / 多剤耐性 / がん悪液質 / 耐性克服 / がん性悪疫質 / センソ / 天然物 / 悪液質 / インドールアルカロイド / イソプレノイド / ブフォゲニン / 分子標的治療 / アポトーシス / 成人T細胞白血病・リンパ腫 / 分子標的薬 / 天然由来物質 / 天然物質 / 分子標的治療薬 / 微生物二次代謝産物 / HIF-1α / 低酸素 / 乳がん / 血管内皮増殖因子 / 非相同組換え / 染色体再編成 / DNA二本鎖切断 / DNAエンドジョイニング / DNAジャイレース / RecQヘリケース / RecFORタンパク質 / Sgs1ヘリケース / 非相同的組換え / DNA二重鎖切断 / 増殖静止期 / 飢餓 / DNAアルキル化 / adaptive mutation / adaptive amplification / RecEエキソヌクレアーゼ / H-NSタンパク質 / Tag DNAグリコシラーゼ / DNAトポイソメラーゼII / WRNヘリケース / DnaBヘリケース / DNA損傷 / DNAリガーゼ / 遺伝的組換え / サイレンシング因子 / 修復 / 組換え / Ku蛋白質 / DNAヘリケース / 老化 / SGSI遺伝子 / DNAヘリカーゼ / BLM遺伝子 / WRN遺伝子 / DNA損傷のチェックポイント / Chromosomal aberration / DNA double-strand break / DNA end-joining / Illegitimate recombination / DNA gyrase / RecQ helicase / RecROF proteins / Sgsl helicase / 抗マラリア剤 / 天然物化学 / 微生物素材 / 植物素材 / 活性物質の精製 / 活性物質の構造決定 / 海洋生物素材 / 誘導体合成 / antimalarial drugs / chemistry of natural products / microbial resource / plant resource / purification of active compounds / elucidation of structure / marine products / synthesis of derivatives / キニノゲン欠損ラット / 高分子キニノゲン / T-キニノゲン / カラゲニン胸膜炎 / 炎症反応 / アラキドン酸代謝物 / 低分子キニノゲン / ラジオイムノアッセイ / Tーキニノゲン / 急性相蛋白質 / 性差 / カリクレイン・キニン系 / ブラジキニン / カプトプリル / カラゲニン足浮腫 / HMW-kininogen / LMW-kininogen / T-kininogen / Inflammation / Rat pleurisy / Kininogen-deficient rat / Eicosanoids / Radioimmunoassay Less
  • Research Projects

    (11 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (33 People)
  •  Search on molecular target cancer drug from microbial secondary metabolites

    • Principal Investigator
      KIM Yongpil
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Iwaki Meisei University
  •  Natural compounds that enhance TRAIL-induced apoptosis : a novel molecular targeted cancer therapy

    • Principal Investigator
      HASEGAWA Hiroo
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Nagasaki University
  •  天然由来鍵化合物の探索と病態解析への応用Principal Investigator

    • Principal Investigator
      林 正彦
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Science and Engineering
    • Research Institution
      Kitasato Institute
  •  天然由来抗腫瘍性物質の開拓と病態解析への応用

    • Principal Investigator
      小宮山 寛機
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kitasato Institute
  •  天然より得られた抗腫瘍物質の作用機序解析と実験病態モデルでの評価

    • Principal Investigator
      小宮山 寛機
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kitasato Institute
  •  新規天然制癌物質の探索とその作用機序の解明

    • Principal Investigator
      石塚 雅章
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Microbial Chemistry Research Foundation
  •  天然物由来癌転移抑制物質の研究

    • Principal Investigator
      小宮山 寛機
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kitasato Institute
  •  Research of the antimalarial drugs from the natural products

    • Principal Investigator
      OMURA Satoshi
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kitasato University
      Kitasato Institute
  •  Mechanisms of recombination mediated by DNA end-joining

    • Principal Investigator
      OGATA Yasuyuki, IKEDA Hideo
    • Project Period (FY)
      1998 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Genetics
      Kitasato Institute
      The University of Tokyo
  •  白血病細胞のアポトーシス誘導ならびに浸潤阻止のための制御技術と天然薬物の開発

    • Principal Investigator
      片桐 拓也
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kitasato Institute
  •  Biological role of kininogens; Studies using kininogen deficient rats.

    • Principal Investigator
      OH-ISHI Sachiko
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kitasato University, School of Pharm.Sci.

All 2011 2010 2009 2007 2004

All Journal Article Presentation Book

  • [Book] 「Interleukin-6阻害物質と病態への応用」、血液・腫瘍科2004

    • Author(s)
      林 正彦
    • Total Pages
      10
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-13218140
  • [Journal Article] TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina.2009

    • Author(s)
      M. Ozawa, T. Etoh, M. Hayashi, K. Komiyama, A. Kishida, A. Ohsaki
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Pages: 234-236

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590107
  • [Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production2007

    • Author(s)
      長谷川寛雄, 山田恭暉, 小宮山寛機, 林正彦, 石橋正巳, 砂塚敏明, 菅原和行, 鶴田一人, 増田昌人, 高須信行, 塚崎邦弘, 朝長万左男, 上平憲
    • Journal Title

      Blood 110(5)

      Pages: 1664-74

    • Data Source
      KAKENHI-PROJECT-18590510
  • [Presentation] 低酸素下HIF-1αの細胞内蓄積抑制作用を有する化合物の作用機序2011

    • Author(s)
      金容必、関寧、江藤忠洋、林正彦、田中晴雄
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-20590107
  • [Presentation] TLRシグナル伝達阻害物質berkeleyacetal Cの標的分子の解明2010

    • Author(s)
      江藤忠洋、金容必、田中晴雄、林正彦
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20590107
  • [Presentation] 土壌糸状菌由来chaetochromin類の低酸素応答性転写因子HIF-1に対する作用2010

    • Author(s)
      関寧、金容必、江藤忠洋、林正彦、田中晴雄
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20590107
  • [Presentation] 土壌由来糸状菌の生産する抗炎症物質berkeleyacetal Cの作用機序に関する研究2009

    • Author(s)
      江藤忠洋、金容必、田中晴雄、林正彦
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20590107
  • 1.  小宮山 寛機 (00106676)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 2.  深海 明子 (60300745)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  TOMODA Hiroshi (70164043)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  OGATA Yasuyuki (90344449)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  IKEDA Hideo (10012775)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  HASEGAWA Hiroo (00398166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  KIM Yongpil (70337997)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  NIKI Hironori (70208122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  OMURA Satoshi (90050426)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OTOGURO Kazuhiko (80118794)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YAMADA Haruki (60096691)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  UI Hideaki (90290957)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KIYOHARA Hiroaki (70161601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OH-ISHI Sachiko (70050416)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  UTSUNOMIYA Iku (70168722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YAMAKI Kohji (70174597)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HAYASHI Izumi (90172999)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  片桐 拓也 (70126100)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  塚本 俊彦 (10236862)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  石塚 雅章 (80159722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  上村 大輔 (00022731)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  伏谷 伸宏 (70012010)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  瀬戸 治男 (10013335)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  長田 裕之 (80160836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  小林 淳一 (90221241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  浅沼 史樹 (40129309)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  山田 恭暉 (60145232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 28.  上平 憲 (80108290)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 29.  舘林 和夫 (50272498)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  加藤 潤一 (10194820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  塩見 和朗 (40235502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  彌益 暁子 (80174697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  KANN Toh?Seok
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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