naraba hiroaki 奈良場博昭

… Alternative Names

Researcher Number	90296517
Affiliation (Current)	2021: 岩手医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 岩手医科大学, 薬学部, 教授 2008 – 2010: Iwate Medical University, 薬学部, 准教授 2005 – 2006: 岩手医科大学, 医学部, 助教授 2004: 国立循環器病センター研究所, 疫学部, 室長 2001 – 2003: 国立循環器病センター研究所, 薬理部, 室員 2001: National Cardiovascular Center, 薬理部, 研究員 1998 – 2000: 北里大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / 応用薬理学・医療系薬学 / Biology of Cells to Organisms, and related fields Except Principal Investigator 応用薬理学・医療系薬学 / Biological pharmacy / General medical chemistry
Keywords	Principal Investigator プロスタグランジン / 炎症 / ブラジキニン / 転写調節因子 / 初期応答遺伝子 / シクロオキシゲナーゼ / B1受容体 / MAPキナーゼ / AP-1 / 血管内皮細胞 … More Except Principal Investigator PGE2 / 炎症 / Cyclooxygenase / Hsp90 / PPAR-delta / アラキドン酸 / COX-2 / PGE合成酵素 / PGI2 / エンドトキシン / マクロファージ / PGI_2 / ホスホリパーゼA_2 / シクロオキシゲナーゼ-1 / シクロオキシゲナーゼ-2 / プロスタグランジンE_2 / プロスタグランジンD_2 / トロンボキサンB_2 / リポポリサッカライド / Arachidonate Metabolites / Prostaglandins / PDE synthase / Inducible enzyme / Macrophages / ブラジキニン / アンタボンスト / 受容体 / アンタゴニスト / BRADYKININ / INFLAMMATION / ANTAGONIST / RECEPTORS / PGE2合成酵素 / シクロオキシゲナーゼ / 大腸癌 / アラキドン酸代謝 / PGE_2 / PGE_2 synthase / Colon tumors / Arachidonic acid / Inflamamtory / プロスタサイクリン / プロスタグランジン / プロスタサイクリン合成酵素 / ノックアウトマウス / 血管内皮細胞 / 腎臓 / 動脈硬化 / サイトカイン / プロスタサイクリン合成酵素(3) / PPARδ / プロスタグランジンE合成酵素(6) / Egr-1 / 血管 / prostacyclin / prostaglandin / prostacyclin synthase / knockout mice / vascular endothelial cells / kidney / arteriosclerosis Less

Role of exosomes as secretory vesicles in the pathophysiology of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  NARABA HIROAKI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biology of Cells to Organisms, and related fields
- Research Institution
  Iwate Medical University
Involvement of membrane-associated prostaglandin E synthase-1 in neovascularization.Principal Investigator
- Principal Investigator
  
  NARABA Hiroaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Iwate Medical University
NoncodingRNAによるプロスタグランジン合成酵素の発現制御機構の解析Principal Investigator
- Principal Investigator
  
  奈良場博昭
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Iwate Medical University
プロスタグランジンE2合成酵素の転写調節機構の解明とその制御法の開発Principal Investigator
- Principal Investigator
  
  奈良場博昭
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  National Cardiovascular Center Research Institute
Studies onfanction of prostacyclin and thromboxane in vascular disorders
- Principal Investigator
  
  YOKOYAMA Chieko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  National Cardiovascular Center Research Institute
プロスタグランジンE_2産生におけるブラジキニンB1受容体の役割Principal Investigator
- Principal Investigator
  
  奈良場博昭
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  National Cardiovascular Center Research Institute
Analysis of prostaglandin E2 synthases
- Principal Investigator
  
  KUDO Ichiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
ブラジキニンB1,B2受容体の発現とその機能解析Principal Investigator
- Principal Investigator
  
  奈良場博昭
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kitasato University
THE RESEARCH FOR THE ROLES OF BRADYKININ RECEPTORS IN THE INFLAMMATORY RESPONSE
- Principal Investigator
  
  UENO Akinori
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KITASATO UNIVERSITY
Functional coupling of arachidonate metabolizing enzymes
- Principal Investigator
  
  OH-ISHI Sachiko
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kitasato University

All 2019 2018 2010 2008 2006 2005 2004

All Journal Article Presentation

[Journal Article] DNA damage-induced modulation of GLUT3 expression is mediated through p53-independent extracellular signal-regulated kinase signaling in HeLa cells.2010
- Author(s)
  Watanabe M, Naraba H, Sakyo T, Kitagawa T.
- Journal Title
  
  Mol Cancer Res. 8(11)
  
  Pages: 1547-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590259
[Journal Article] Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy.2008
- Author(s)
  Yuhki K, Ushikubi F, Naraba H, Ueno A, Kato H, Kojima F, Narumiya S, Sugimoto Y, Matsushita M, Oh-Ishi S.
- Journal Title
  
  J Pharmacol Exp Ther. 325(2)
  
  Pages: 601-609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590259
[Journal Article] MicroRNA and 3T3-L1 pre-adipocyte differentiation.2006
- Author(s)
  Kajimoto K, Naraba H, Iwai N
- Journal Title
  
  RNA 12・9
  
  Pages: 1626-1632
- Data Source
  KAKENHI-PROJECT-17790177
[Journal Article] Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study2005
- Author(s)
  Kokubo Y, Iwai N, Tago N, Inamoto N, Okayama A, Yamawaki H, Naraba H, Tomoike H
- Journal Title
  
  Circ J. 69・2
  
  Pages: 1218-1224
- NAID
  110002696060
- Data Source
  KAKENHI-PROJECT-17790177
[Journal Article] Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat2005
- Author(s)
  Iwai N, Yasui N, Naraba H, Tago N, Yamawaki H, Sumiya H
- Journal Title
  
  Hypertension 45・5
  
  Pages: 947-953
- Data Source
  KAKENHI-PROJECT-17790177
[Journal Article] Functional confirmation of Gitelman's syndrome mutations in Japanese2005
- Author(s)
  Naraba H, Kokubo Y, Tomoike H, Iwai N
- Journal Title
  
  Hypertens Res. 28・10
  
  Pages: 805-809
- NAID
  10018367130
- Data Source
  KAKENHI-PROJECT-17790177
[Journal Article] Assessment of the microRNA system in salt-sensitive hypertension2005
- Author(s)
  Naraba H, Iwai N
- Journal Title
  
  Hypertens Res. 28・10
  
  Pages: 819-826
- NAID
  10018367175
- Data Source
  KAKENHI-PROJECT-17790177
[Journal Article] Polymorphisms in human pre-miRNAs2005
- Author(s)
  Iwai N, Naraba H
- Journal Title
  
  Biochem Biophys Res Commun 331・4
  
  Pages: 1439-1444
- Data Source
  KAKENHI-PROJECT-17790177
[Journal Article] Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.2004
- Author(s)
  Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S.
- Journal Title
  
  Arthritis Res Ther. 6(4)
- Data Source
  KAKENHI-PROJECT-15790142
[Journal Article] A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese population.2004
- Author(s)
  Shioji K, Nishioka J, Naraba H, Kokubo Y, Mannami T, Iwai N. et al.
- Journal Title
  
  J Hum Genet. 49(3)
  
  Pages: 141-147
- NAID
  10012891138
- Data Source
  KAKENHI-PROJECT-15790142
[Journal Article] Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy.2004
- Author(s)
  Yuhki K, Ueno A, Naraba H, Kojima F, Ushikubi F, Narumiya S, Oh-ishi S.
- Journal Title
  
  J Pharmacol Exp Ther. 311(3)
  
  Pages: 1218-1224
- Data Source
  KAKENHI-PROJECT-15790142
[Journal Article] Association analysis between hypertension and CYBA, CLCNKB, and KCNMBI functional polymorphisms in the Japanese population--the Suita Study.2004
- Author(s)
  Kokubo Y, Iwai N, Tago N, Inamoto N, Okayama A, Yamawaki H, Naraba H, Tomoike H.
- Journal Title
  
  Circ J. 69(2)
  
  Pages: 138-142
- Data Source
  KAKENHI-PROJECT-15790142
[Journal Article] A high prevalence of Gitelman's syndrome mutations in Japanese.2004
- Author(s)
  Tago N, Kokubo Y, Inamoto N, Naraba H, Tomoike H, Iwai N.
- Journal Title
  
  Hypertens Res. 27(5)
  
  Pages: 327-331
- NAID
  10013603834
- Data Source
  KAKENHI-PROJECT-15790142
[Presentation] 慢性関節リウマチモデルマウスの血中エクソソームにおける低分子RNAと病態の関係2019
- Author(s)
  奈良場博昭、青山玲子
- Organizer
  第40回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-17K19405
[Presentation] 関節リウマチの炎症症状とエクソソーム由来マイクロRNAの発現変動の検討2019
- Author(s)
  岩花諒、青山玲子、奈良場博昭
- Organizer
  第58回日本薬学会東北支部会
- Data Source
  KAKENHI-PROJECT-17K19405
[Presentation] 慢性関節リウマチモデルマウスの血中エクソソームにおける低分子RNAと病態の関係2018
- Author(s)
  奈良場博昭
- Organizer
  日本炎症再生医学会
- Data Source
  KAKENHI-PROJECT-17K19405

1. UENO Akinori (00112657)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KUDO Ichiro (30134612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MURAKAMI Makoto (60276607)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IKEDA Yuri (10306657)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OH-ISHI Sachiko (70050416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKATANI Yoshihito (80266163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YOKOYAMA Chieko (90200914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TOSHIHISA Hatae (10251026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宇都宮郁 (70168722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 奈良場博昭 (13771443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAMIMURA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUGIMOTO Masamichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

naraba hiroaki 奈良場 博昭

NARABA HIROAKI 奈良場 博昭

NARABA Hiroaki 奈良場 博昭

Research Projects

Research Products

Co-Researchers

Role of exosomes as secretory vesicles in the pathophysiology of rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of membrane-associated prostaglandin E synthase-1 in neovascularization.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NoncodingRNAによるプロスタグランジン合成酵素の発現制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プロスタグランジンE2合成酵素の転写調節機構の解明とその制御法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies onfanction of prostacyclin and thromboxane in vascular disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プロスタグランジンE_2産生におけるブラジキニンB1受容体の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of prostaglandin E2 synthases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ブラジキニンB1,B2受容体の発現とその機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE RESEARCH FOR THE ROLES OF BRADYKININ RECEPTORS IN THE INFLAMMATORY RESPONSE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional coupling of arachidonate metabolizing enzymes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] DNA damage-induced modulation of GLUT3 expression is mediated through p53-independent extracellular signal-regulated kinase signaling in HeLa cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy.2008

Author(s)

Journal Title

Data Source

[Journal Article] MicroRNA and 3T3-L1 pre-adipocyte differentiation.2006

Author(s)

Journal Title

Data Source

[Journal Article] Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study2005

Author(s)

naraba hiroaki 奈良場博昭

NARABA HIROAKI 奈良場博昭

NARABA Hiroaki 奈良場博昭