UTSUMI Hideo 内海英雄

… Alternative Names

Researcher Number	20101694
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Affiliation *help	2016 – 2018 : 静岡県立大学, 薬学部, 客員教授 2015 : 静岡県立大学, 薬学部, その他 2010 – 2014 : 九州大学, 先端融合医療レドックスナビ研究拠点, 特任教授 2007 : 九州大学, 大学院・薬学研究院, 教授 2006 – 2007 : 九州大学, 薬学研究院, 教授 … More
Review Section/Research Field	Principal Investigator Physical pharmacy / Biological pharmacy / Physical pharmacy / 応用薬理学・医療系薬学 / Science and Engineering / Biomedical engineering/Biological material science / Environmental pharmacy / Medical pharmacy Except Principal Investigator Physical pharmacy / Circulatory organs internal medicine … More
Keywords	Principal Investigator フリーラジカル / 活性酸素 / ESR / スピンプローブ / 酸化ストレス / 生体計測ESR / reactive oxygen species / レドックス / 電子スピン共鳴 / MRI … More Except Principal Investigator 活性酸素 / ESR / L-バンドESR / 一酸化窒素 / 酸化ストレス / 心不全 / nitric oxide / X-バンドESR / 動脈硬化 / L-band ESR / スピンラベル / 活性酸素種 / 炎症 / アンジオテンシンII / フリーラジカル / monocyte chemoattractant protein-1 / arteriosclerosis / 韓国 / Oxidative stress / fibrosis / 汚濁負荷 / NF-κB / DNA / superoxide anion / ESR imaging / Korea / 抗酸化酵素 / 電子スピン共鳴法 / NF-kB / 転写因子 / peroxynitrite / ニトロキシド / reactive oxygen species / 洛東江 / MCP-1 / 流域管理システム / ミトコンドリア / トリハロメタン / inflammation / Nak-Dong River / THMs / Mitochondria / Aquatic ecosystem / Pollution loads / Nitroxide / スピンクリアランス / River basin management system / Heart failure / バイオアッセイ / 血管内皮 / サイトカイン / 無侵襲測定 / 水界生態系 / 膜 / gene transfer / 水処理 / ケモカイン / 体内動態 / 生理活性物質 / 細胞毒性 / レニン・アンジオテンシン系 / タンパク結合 / 薬物担体 / 過酸化水素 / 細胞内酸素濃度 / メタボリック・プロファイリング / 生物学的環境モニタリング / Cytokine / LーバンドESR / Spin-Label / CARCINOGENS IN ENVIRONMENTAL WATER / 公共用水域 / ESRイメージング / 組織因子 / 肥満 / NanoScience / 薬理機能 / Ultraviolet Radiation B / 色素性乾皮症 / 生体内酸素濃度測定法 / ダニアレルギー / 薬物動態 / 虚血・再潅流 / Molecular magnetism / ニトロキシルラジカル / 交感神経系 / Diffusion / 生物膜 / 活性炭 / 高分離分析法 / 常磁性金属イオン / 分子スピン / 健康影響 / 内皮由来池緩因子 / 一酸化水素 / 活性酵素種 / 重金属の毒性発現 / ライフサイエンス / バイオイメージング / free radical / γ-グルタミルトランスペプチダーゼ / 核酸治療 / 心筋梗塞 / ニトロキシドラジカル / metal ion / 光化学反応 / 腐植物質 / Hydrogen peroxide / 浄化システム / オゾン処理 / Antioxidative Enzymes / Nitric oxide / プロテオーム / ニトロキシド化合物 / in vivo ERS / スピンプローブ / Paramagnetic probe / イオン交換 / 制御物質 / ADSORBENT FOR MUTAGEN / nitric oxide (NO) / Rho-キナーゼ / ENVIRONMENTAL POLLUTION / DNA鎖修復 / 高選択検出法 / 遺伝子導入 / Skin Cancer Risk Factor / Aquatic microorganism / Personal computer / 時間荷重平均 / パラコート / 非侵襲的治療応答性アッセイ / Oxidative Stress / Imaging / in vitro measurement / 心筋細胞 / 電子伝達系 / 生体内酸素 / 単球走化因子 / in vivo measurement / 心拍数 / nitroxyl radical / Ischemia-Reperfusion / ホスホリパーゼA_2 / 虚血 / 好中球 / Electron transport complex / Photolysis / レドックスイメージング / 紫外線B / 一酸化炭素 / Oxygen concentration / 光触媒 / 種差 / 電磁場 / リモデリング / 水域発がん物質 / NO / 一酸化窒素(NO) / NF-KB / 常磁性 / 接着因子 / 内皮由来過分極因子(EDHF) / アポE欠損マウス / 分子磁性 / 内皮由来過分極因子 / Genetic Polymorphism / 環境汚染 / バイオサイエンス / BCM-ESR / trapping agent / Adsorption of activated carbon / 光化学 / BioScience / レドックスイメージ / 重粒子線 / Rho-kinase / 生理機能 / メタボリックシンドローム / Mutagenicity / 酸化損傷 / パーオキシナイトライト / Species Difference / アンジオテンシン変換酵素 / Myocyte / Remodeling / inflammatory cytokine / 常磁性プローブ / 遺伝子導入細胞 / HLA分子 / 遺伝子治療 / ブルーキチンカラム濃縮法 / 皮膚癌危険因子 / Atherosclerosis / HLAクラスII分子 / heart failure / Drug Metabolism / 酸化的ストレス / 薬物代謝 / BIOLOGICAL MONITORING / 内皮型NO合成酵素(eNOS) / 溶存物質 / Endothelium-derived relaxing factors / 重金属 / Cytotoxicity / バイオサイセンス / 抗酸化薬 / 生体ラジカル / 水系微生物 / 微小循環 / PDS / ROS / Endothelium-derived hyperpolarizing factor / トランスジェニックマウス / マウス / Molecular Spins / 活性炭吸着 / 画像解析 / 殺菌 / 筋肉内薬物動態 / インスリン / 遺伝的多型性 / 突然変異頻度 / Bio-assay / NOS欠損マウス / oxidative stress / in vivo ESR / 大腸癌形成 / 活性酸素消去因子 / 内皮由来弛緩因子 / ミトコンドア / 極低周波電磁場 / ディーゼル排気粒子 / 繊維化 / 炎症性サイトカイン / 抗原ペプチド / 変異原吸着剤 / Microcirculation / メタボリック・プロファイリング / トラップ剤 / ナノテクノロジー / Humic substances / 紫外線 / 硝酸イオン / OMRI / 再潅流 / 化学物質の毒性発現 / 酸化窒素 / mouse / オゾン / 脳 / 酸素濃度 / ウィルス / 免疫応答 / 変異原性 / 酸素傷害 / 肺 / BLUE CHITIN COLUMN / eNOS欠損マウス / 非侵襲的治療応答アッセイ / ヒドロキシルラジカル / cytokine / 水銀化合物の腎毒性 / Cardiovascular diseases / LバンドESR / インビトロ計測 / transgenic mice / Ion-exchanger / インビボ計測 / Toxicity of Heavy metals / リポソ-ム / spin probe / Membrane separation / SOD / 放射線 / 血圧 / パ-ソナルコンピュ-タ / spin-label / 膜処理 / X-band ESR / 吸着 / adhesion molecules / ブルーレイヨンカラム濃縮法 / ナノサイエンス / Free radicals / 筋肉 / 心血管病 Less

Studies on the Development of Clinical Free Radical Imaging SystmePrincipal InvestigatorOngoing
- Principal Investigator
  
  内海英雄
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Development of free radical imaging using in vivo DNP-MRIPrincipal Investigator
- Principal Investigator
  
  Utsumi Hideo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
  Kyushu University
Imaging study of redox status in vivo in oxidative stress-associateddisease model animals using OMRIPrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
Non-invasive assessment for therapeutic response to gene therapy using redox imaging and MALDI-TOF mass-spectrometry
- Principal Investigator
  
  NAKANO Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
Hypertension in metabolic syndrome : Mechanism involved in activation of the sympathetic nervous system and therapeutic approach
- Principal Investigator
  
  HIROOKA Yoshitaka
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyushu University
Experimental and Clinical Studies on the Significance of Endothelium-Derived Hyperpolarizing Factor (EDHF)
- Principal Investigator
  
  SHIMOKAWA Hiroaki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tohoku University
  Kyushu University
Application of Molecular Spins : from Nanomagnets to Biological Spin Systems
- Principal Investigator
  
  AWAGA Kunio
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Nagoya University
Analysis of free radical reactions in diseases model animals using in vivo ESRIPrincipal Investigator
- Principal Investigator
  
  USUMI Hideo
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyushu University
生体ラジカル二重共鳴画像解析用共振デバイスと画像化システムの開発Principal Investigator
- Principal Investigator
  
  内海英雄
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
Non-invasive analysis of dynamic state of reactive oxygen species in tissue and blood vessel of circulatory diseasesPrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University
Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure
- Principal Investigator
  
  TSUTSUI Hiroyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  HOKKAIDO UNIVERSITY
  Kyushu University
Development of ESRI・MRI fused imaging device for oxidative stress-related diseasesPrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
Elucidating the mechanism of heart failure using mouse model of dilated cardiomyopathy
- Principal Investigator
  
  KUBOTA Toru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
疾患成因に関わる活性酸素・活性窒素の無侵襲画像解析手法の開発Principal Investigator
- Principal Investigator
  
  内海英雄
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kyushu University
Non-invasive evaluation of free radical reactions accompanied with induction and development of heart failure by in vivo ESR-CTPrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
Mechanisms of oxygen radical generation in the mitochondria from the failing hearts
- Principal Investigator
  
  TSUTSUI Hiroyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES
MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-_B AND MCP-1
- Principal Investigator
  
  EGASHIRA Kensuke
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Development of non-invasive system for the evaluation of free radicals in brain with encephalopathy.Principal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Physical pharmacy
- Research Institution
  KYUSHU UNIVERSITY
水処理操作における有害物質の消長の検討
- Principal Investigator
  
  市川和洋
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
生体計測ESRによる炎症時におけるレドックス代謝活性の無侵襲画像解析Principal Investigator
- Principal Investigator
  
  内海英雄
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyushu University
超微量分子および分子集合体の高度機能解析およびイメージングに関する研究
- Principal Investigator
  
  中川照眞
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
生体を指向した新しい電子スピン共鳴法の医学・薬学的応用
- Principal Investigator
  
  OZAWA Toshihiko
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Radiological Sciences
MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-κB AND MCP-1
- Principal Investigator
  
  TAKESHITA Akira
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Development of non-invasive evaluation of oxidative stress against living organisms by in vivo ESR
- Principal Investigator
  
  OZAWA Toshihiko
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Radiological Sciences
Analysis of toxicity by organic halogens with in vivo ESR and transgenic micePrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  KYUSHU UNIVERSITY
オゾン処理による水中有機物の反応経路の検討
- Principal Investigator
  
  ICHIKAWA Kazuhiro
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
脳細胞の生存・機能維持におけるフリーラジカルの関与Principal Investigator
- Principal Investigator
  
  内海英雄
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
生体内で発生する活性酸素の無侵襲検出法の開発
- Principal Investigator
  
  竹下啓蔵
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
Development of Chronic Heart Failure Model Caused by Inflammatory Cytokines and Establishment of Prophylactic and Therapeutic Strategies for the Heart Failure
- Principal Investigator
  
  SHIMOKAWA Hiroaki
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
酸化ストレスに着目した有害物質の毒性評価法の開発Principal Investigator
- Principal Investigator
  
  内海秀雄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
ESR studies on biological free radicals in pharmaceutical sciences
- Principal Investigator
  
  SAKURAI Hiromu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
EVALUATION OF THE MUTAGENICITY IN THE ENVIRONMENTAL WATER
- Principal Investigator
  
  HAYATSU Hikoya
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental dynamic analysis
- Research Institution
  OKAYAMA UNIVERSITY
Roles of in vivo REDOX systems by using in vivo ESR and transgenic micePrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYUSHU UNIVERSITY
培養細胞系を用いた有害物質の包括的評価法の開発Principal Investigator
- Principal Investigator
  
  内海英雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
The study on comprehensive methods for estimaiton of new water treatment technology
- Principal Investigator
  
  OHGAKI Shin-ichiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  環境保全
- Research Institution
  UNIVERSITY OF TOKYO
Development of in vivo ESR for detecting free radicals in human living bodyPrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
非特定多様有害物質の毒性低減化に向けた新評価法の開発Principal Investigator
- Principal Investigator
  
  内海英雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Showa University
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Genetic Determinants Affecting Sensitivity to Environmental Factors-
- Principal Investigator
  
  IMURA Nobumasa
- Project Period (FY)
  1993 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
Management and restoration of river ecosystem and resources
- Principal Investigator
  
  SUZUKI Motoyuki
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  The University of Tokyo
Development of a Method for Measuring Oxyngen Concentration in Biological Systems by Means of ESR
- Principal Investigator
  
  KIRINO Yutaka
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
  Kyushu University
Study of Free Radicals in Tissue and Transdermal Drug Delivery by using in vivo ESR with Spectral-Spatial ESR-CT ImagingPrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Showa University
生物関連汚濁に対応する水質改善技術
- Principal Investigator
  
  SUZUKI T
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Yamanashi
Analysis of Human Impacts on the Deterioration of an Aquatic Ecosystem in Korea and Development of a Computer-Aided System for Basin-Wide Management
- Principal Investigator
  
  SUZUKI Motoyuki
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Overseas Scientific Survey.
- Research Institution
  The University of Tokyo
Real Time Analysis of Drug-Diffusion in Muscle with in vivo ESR-Spectroscopy
- Principal Investigator
  
  HAMADA Akira
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Showa University
Development of in situ liver function measurement with a L-band ESR imaging techniquePrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Studies on the relation between the biological function and the dynamic properties of rat liver plasma and microsomal membranesPrincipal Investigator
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University

[Book] Methods Mol Biol, Brain redox imaging2011
- Author(s)
  Matsumoto K, Hyodo F, Anzai K,Utsumi H, Mitchell J.B., Krishna M.C.
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] In Vivo Application of Proton-Electron Double-Resonance Imaging2018
- Author(s)
  Kishimoto Shun、Krishna Murali C.、Khramtsov Valery V.、Utsumi Hideo、Lurie David J.
- Journal Title
  
  Antioxidants & Redox Signaling
  
  Volume : 28 Pages : 1345-1364
- DOI
  10.1089/ars.2017.7341
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05113
[Journal Article] In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging2018
- Author(s)
  Yasukawa Keiji、Shigemi Ryota、Kanbe Tomomi、Mutsumoto Yusaku、Oda Fumiko、Ichikawa Kazuhiro、Yamada Ken-Ichi、Tun Xin、Utsumi Hideo
- Journal Title
  
  Antioxidants & Redox Signaling
  
  Volume : in press
- DOI
  10.1089/ars.2017.7336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05113
[Journal Article] Dynamic Nuclear Polarization Studies on Deuterated Nitroxyl Spin Probes2017
- Author(s)
  David Jebaraj D, Hideo Utsumi, Milton Franklin Benial A
- Journal Title
  
  Magnetic Resonance in Chemistry
  
  Volume : 26 April
- DOI
  10.1002/mrc.4602
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05113
[Journal Article] Electron spin resonance studies on deuterated nitroxyl spin probes used in Overhauser-enhanced magnetic resonance imaging2017
- Author(s)
  D. David Jebaraj, Hideo Utsumi, A. Milton Franklin Benial
- Journal Title
  
  Magnetic Resonance in Chemistry
  
  Volume : 1 February
- DOI
  10.1002/mrc.4576
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05113
[Journal Article] ESR line width and line shape dependence of Overhauser-enhanced magnetic resonance imaging2016
- Author(s)
  Meenakumari Y, Utsumi H, Jawahar A, Benial AM
- Journal Title
  
  Applied Magnetic Resonance
  
  Volume : in press
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] Redox imaging of skeletal muscle using in vivo OMRI and its application to an animal model of local inflammation2016
- Author(s)
  Eto H, Hyodo F, Kosem N, Kobayashi R, Yasukawa K, Nakao M, Kiniwa M, Utsumi H
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume : in press
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] Imaging ROS and ROS-induced Modifications in living systems2016
- Author(s)
  Maulucci G, Bačić G, Bridel L, Yalçın AS, Schmidt H, Stocker R, Utsumi H, and Spirito M
- Journal Title
  
  Antioxi. Redox Signal
  
  Volume : in press
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] Visit-to-visit variability and seasonal variation in blood pressure: Combination of Antihypertensive Therapy in the Elderly, Multicenter Investigation (CAMUI) Trial subanalysis.2015
- Author(s)
  Isegawa K, Hirooka Y, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
- Journal Title
  
  Clin Exp Hypertens
  
  Volume : 37(1) Pages : 245-255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253005, KAKENHI-PROJECT-26461052, KAKENHI-PROJECT-25560215
[Journal Article] Free Radical Imaging using in vivo Dynamic Nuclear Polarization - MRI2015
- Author(s)
  Utsumi H, Hyodo F.
- Journal Title
  
  Methods in Enzymology
  
  Volume : 564 Pages : 554-571
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] iffusion studies of redox-sensitive nitroxyl spin probes through bilayer lipid membranes using 300 MHz electron spin resonance spectrometer2015
- Author(s)
  Benial AM, Dhas MK, Ichikawa K, Yamada K, Hyodo F, Jawahar A, Utsumi H
- Journal Title
  
  Biofizika. 60(1) 88-94 2015
  
  Volume : 60 Pages : 88-94
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease2014
- Author(s)
  Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S
- Journal Title
  
  Sci Rep.
  
  Volume : 4 Pages : 4957-4957
- DOI
  10.1038/srep04957
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24650227, KAKENHI-ORGANIZER-25117001, KAKENHI-PROJECT-25253005, KAKENHI-PROJECT-26670541, KAKENHI-PROJECT-26713039, KAKENHI-PROJECT-26860933
[Journal Article] Nitroxyl radicals-modified dendritic poly(l-lysine) as a contrast agent for Overhauser-enhanced MRI.2014
- Author(s)
  Niidome T, Gokuden R, Watanabe K, Mori T, Naganuma T, Utsumi H, Ichikawa K, Katayama Y.
- Journal Title
  
  J Biomater Sci Polym Ed.
  
  Volume : 25(13) Pages : 1425-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] 磁気共鳴画像化法による生体酸化還元反応の可視化2014
- Author(s)
  兵藤文紀、伊藤慎治、内海英雄
- Journal Title
  
  BUNSEKI KAGAKU
  
  Volume : 63(6) Pages : 467-476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] Neurotransmitters,Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry2013
- Author(s)
  Kato TA, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S
- Journal Title
  
  Curr Med Chem
  
  Volume : 20 (3) Pages : 331-44
- URL
  http://www.eurekaselect.com/106225/article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] In vivo toxicity and antitumor activity of mangosteen extract.2013
- Author(s)
  Kosem N, Ichikawa K, Utsumi H, Moongkarndi P.
- Journal Title
  
  J Nat Med.
  
  Volume : 67(2) Pages : 255-63
- DOI
  10.1007/s11418-012-0673-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650216, KAKENHI-PROJECT-25253005, KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-24300183
[Journal Article] Moxinidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure.2013
- Author(s)
  Honda N, Hirooka Y, Ito K, Matsukawa R, Shinohara K, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
- Journal Title
  
  Journal of Hypertension
  
  Volume : 31 Pages : 2300-2308
- DOI
  10.1097/HJH.0b013e328364a2a1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-24390198, KAKENHI-PROJECT-25253005
[Journal Article] Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer2013
- Author(s)
  Benial AM, Dhas MK, Ichikawa K, Yamada KI, Hyodo F , Jawahar A, Utsumi H
- Journal Title
  
  Appl Magn Reson.
  
  Volume : 44(4) Pages : 439-47
- DOI
  10.1007/s00723-012-0383-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-23790050, KAKENHI-PROJECT-24300183
[Journal Article] Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange.2013
- Author(s)
  Watabe, M., Kato, T.A., Tsuboi, S.,Ishikawa, K., Hashiya, K., Monji, A,Utsumi, H., & Kanba, S.
- Journal Title
  
  Scientific Reports
  
  Volume : 3 Pages : 1685-1685
- DOI
  10.1038/srep01685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500242, KAKENHI-PROJECT-23500330, KAKENHI-PROJECT-24650227, KAKENHI-PROJECT-25253005
[Journal Article] Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry.2013
- Author(s)
  Kato TA, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S
- Journal Title
  
  Current Medicinal Chemistry
  
  Volume : 20(3) Pages : 331-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] Novel redox molecular imaging “ReMI” with dual magnetic resonance.2013
- Author(s)
  Utsumi H
- Journal Title
  
  Yakugaku Zasshi
  
  Volume : 133(7) Pages : 803-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253005
[Journal Article] Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI2012
- Author(s)
  Kosem N, Ichikawa K, Utsumi H, Moongkarndi P
- Journal Title
  
  Free Radic Biol Med
  
  Volume : 67(2) Pages : 255-63
- DOI
  10.1016/j.freeradbiomed.2012.04.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-22659111, KAKENHI-PROJECT-23650216, KAKENHI-PROJECT-23790050, KAKENHI-PROJECT-24300183, KAKENHI-PROJECT-24590052
[Journal Article] The detrimental effect of nitric oxide on tissue is associated with infl ammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis.2012
- Author(s)
  Yasukawa K, Tokuda H, Tun X, Utsumi H, Yamada K.
- Journal Title
  
  Free Radic Res.
  
  Volume : 46 Pages : 1427-36
- DOI
  10.3109/10715762.2012.732698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-23790049
[Journal Article] Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats2012
- Author(s)
  Shinohara K, Hirooka Y, Ogawa K, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
- Journal Title
  
  Clinical and Experimental Hypertension
  
  Volume : 34(6) Pages : 456-62
- DOI
  10.3109/10641963.2012.666603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-23220013
[Journal Article] Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors2012
- Author(s)
  Kato, T. A., Watabe, M., Tsuboi, S., Ishikawa, K., Hashiya, K., Monji, A Utsumi, H., & Kanba, S
- Journal Title
  
  PLoS One
  
  Volume : 7(7)
- DOI
  10.1371/journal.pone.0040461
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19046002, KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-22500242, KAKENHI-PROJECT-24650227
[Journal Article] Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer.2012
- Author(s)
  AMF Benial, MK Dhas, K Ichikawa, KI Yamada, F Hyodo, A. Jawahar, H Utsumi.
- Journal Title
  
  Appl Magn Reson.
  
  Volume : -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Overhauser-enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6-hydroxydopamine rat model.2011
- Author(s)
  Yamato M, Shiba T, Naganuma T, Ichikawa K, Utsumi H, Yamada KI
- Journal Title
  
  Neurochem Int
  
  Volume : 59 Pages : 804-811
- DOI
  10.1016/j.neuint.2011.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300169, KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-23650216
[Journal Article] Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats.2011
- Author(s)
  Deguchi H, Yasukawa K, Yamasaki T, Mito F, Kinoshita Y, Naganuma T, Sato S, Yamato M, Ichikawa K, Sakai K, Utsumi H, Yamada KI
- Journal Title
  
  Free Radic Biol Med
  
  Volume : 51 Pages : 1799-805
- DOI
  10.1016/j.freeradbiomed.2011.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300169, KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-23790049
[Journal Article] Structure-Reactivity Relationship of Piperidine Nitroxide: Electrochemical, ESR and Computational Studies2011
- Author(s)
  Toshihide Yamasaki, et al
- Journal Title
  
  J Org Chem
  
  Volume : 76 Pages : 435-440
- DOI
  10.1021/jo101961m
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200034, KAKENHI-PROJECT-21550085, KAKENHI-PROJECT-22249003, KAKENHI-PROJECT-22790038
[Journal Article] In vivo imaging of mitochondrial function in methamphetamine-treated rats2011
- Author(s)
  Shiba T, Yamato M, Kudo W, Watanabe T, Utsumi H, Yamada K.
- Journal Title
  
  Neuroimage
  
  Volume : 57(3) Pages : 866-72
- DOI
  10.1016/j.neuroimage.2011.05.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Anti-Inflammatory properties of antipsychotics via microglia modulations: are antipsychotics a 'fire extinguisher' in the brain of schizophrenia?2011
- Author(s)
  Kato TA, Monji A, Mizoguchi Y, Hashioka S, Horikawa H, Seki Y, Kasai M, Utsumi H, Kanba S.
- Journal Title
  
  Mini Rev Med Chem
  
  Volume : (7) Pages : 565-74
- URL
  http://www.eurekaselect.com/88180/article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia2011
- Author(s)
  Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S
- Journal Title
  
  Schizophr Res.
  
  Volume : 129(2-3) Pages : 172-82
- DOI
  10.1016/j.schres.2011.03.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical2011
- Author(s)
  Mito F, Yamasaki T, Ito Y, Yamato M, Mino H, Sadasue H, Shirahama C, Sakai K, Utsumi H, Yamada K.
- Journal Title
  
  Chem Commun (Camb)
  
  Volume : 7:47(17) Pages : 5070-2
- DOI
  10.1039/c0cc05764a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] In vivo evaluation of nobel nitroxyl radicals with reduction stability2010
- Author(s)
  Kinoshita Y, Yamada K, Yamasaki T, Mito F, Yamato M, Kosem N, Deguchi H, Shirahama C, Ito Y, Kitagawa K, Okukado N, Sakai K, Utsumi H.
- Journal Title
  
  Free Radic Biol Med
  
  Volume : 49(11) Pages : 1703-9
- DOI
  10.1016/j.freeradbiomed.2010.08.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] An EPR method for estimating activity of antioxidants in mouse skin using an anthralin-derived radical model2010
- Author(s)
  Kawai S, Matsumoto K, Utsumi H.
- Journal Title
  
  Free Radic Res.
  
  Volume : 44(3)
- DOI
  10.3109/10715760903456100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Ultrahighly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors.2010
- Author(s)
  Miura D, Fujimura Y, Yamato M, Hyodo F, Utsumi H, Tachibana H, Wariishi H.
- Journal Title
  
  Anal Chem
  
  Volume : 82(23) Pages : 9789-96
- DOI
  10.1021/ac101998z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution2010
- Author(s)
  Benial AM., Utsumi H., Ichikawa K., et al
- Journal Title
  
  J Magn Reson
  
  Volume : 204 Pages : 131-138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution2010
- Author(s)
  Benial AM, Utsumi H, Ichikawa K, Murugesan R, Yamada K, Kinoshita Y, Naganuma T, Kato M.
- Journal Title
  
  J Magn Reson.
  
  Volume : 204(1) Pages : 131-8
- DOI
  10.1016/j.jmr.2010.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Determination of reactive oxygen species associated with the degeneration of dopaminergic neurons during dopamine metabolism.2010
- Author(s)
  Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha M, Ueda T, Hashioka S, Kanba S.
- Journal Title
  
  Free Radic Res.
  
  Volume : 34 Pages : 1306-16
- DOI
  10.1016/j.pnpbp.2010.07.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249003
[Journal Article] Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method.2009
- Author(s)
  Araki S, Hirooka Y, Kishi T, Utsumi H, et al
- Journal Title
  
  Hypertens Res 32
  
  Pages : 1091-1096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method2009
- Author(s)
  Hirooka Y, Kishi T, Utsumi H, et al(3名・2番目)
- Journal Title
  
  Hypertens Res 32
  
  Pages : 1091-1096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390231
[Journal Article] Non-invasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats2006
- Author(s)
  Utsumi H. et al.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 317
  
  Pages : 228-235
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15087102
[Journal Article] Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced magnetic resonance imaging with nitroxyl radicals2006
- Author(s)
  Utsumi H. et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America 103・5
  
  Pages : 1463-1468
- Data Source
  KAKENHI-PROJECT-15087206
[Journal Article] Non-invasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats2006
- Author(s)
  Utsumi H. et al.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics (In press)
- Data Source
  KAKENHI-PROJECT-15087206
[Journal Article] Non-invasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats2006
- Author(s)
  Utsumi H. et al.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 317
  
  Pages : 228-235
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15087206
[Journal Article] In vivo oxygen radical generation in the skin of the protoporphyria model mouse with visible light exposure: An L-band ESR study2004
- Author(s)
  Takeshita, K, Takajo, T, Hirata, H, Ono, M, Utsumi, H
- Journal Title
  
  Journal of Investigative Dermatology 17
  
  Pages : 295-302
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesitv2004
- Author(s)
  Sonta, T, Inoguchi, T, Tsubouchi, H, Sekiguchi, N, Kobayashi, K, Matsumoto, S, Utsumi, H, Nawata, H
- Journal Title
  
  Free Radic Biol Med 37
  
  Pages : 115-123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] In vivo measurement of redox status in streptozotocin-induced diabetic rat using targeted nitroxyl probes.2004
- Author(s)
  Yamada, KI, Inoue, D, Matsumoto, S, Utsumi, H
- Journal Title
  
  Antioxidants & Redox Signaling 6
  
  Pages : 605-611
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Non-invasive analysis of reactive oxygen species generated in rats with water immersion restraint-induced gastric lesions using in vivo electron spin resonance spectroscopy.2004
- Author(s)
  Yasukawa, K., Kasazaki, K., Hyodo, F., Utsumi, H.
- Journal Title
  
  Free Radic Res 38
  
  Pages : 147-155
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice.2004
- Author(s)
  Shiomi, T., Tsutsui, H., Matsusaka, H., Murakami, K., Hayashidani, S., Ikeuchi, M., Wen, J., Kubota, T., Utsumi, H., Takeshita, A.
- Journal Title
  
  Circulation 109
  
  Pages : 544-549
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase.2004
- Author(s)
  Ago, T., Kitazono, T., Ooboshi, H., Iyama, T., Han, Y.H., Takada, J., Wakisaka, M., Ibayashi, S., Utsumi, H., Iida, M.
- Journal Title
  
  Circulation 109
  
  Pages : 227-233
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] In vivo measurement of redox status in streptozotocin-induced diabetic rat using targeted nitroxyl probes2004
- Author(s)
  Yamada, KI, Inoue, D, Matsumoto, S, Utsumi, H
- Journal Title
  
  ANTIOXIDANTS & REDOX SIGNALING 6(3)
  
  Pages : 605-611
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity2004
- Author(s)
  Sonta, T, Inoguchi, T, Tsubouchi, H, Sekiguchi, N, Kobayashi, K, Matsumoto, S, Utsumi, H, Nawata, H
- Journal Title
  
  FREE RADICAL BIOLOGY AND MEDICINE 37(1)
  
  Pages : 115-123
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] In vivo oxygen radical generation in the skin of the protoporphyria model mouse with visible light exposure : An L-band ESR study2004
- Author(s)
  Takeshita, K, Takajo, T, Hirata, H, Ono, M, Utsumi, H.
- Journal Title
  
  JOURNAL OF INVESTIGATIVE DERMATOLOGY 122(6)
  
  Pages : 1463-1470
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice.2004
- Author(s)
  Shiomi T, Tsutsui H, Matsusaka H, Murakami K, Hayashidani S, Ikeuchi M, Wen J, Kubota T, Utsumi H, Takeshita A
- Journal Title
  
  Circulation 109
  
  Pages : 544-549
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.2003
- Author(s)
  Machida Y, Kubota T, Kawamura N, Funakoshi H, Ide T, Utsumi H, Li YY, Feldman AM, Tsutsui H, Shimokawa H, Takeshita A.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke.2003
- Author(s)
  Yamato, M., Egashira, T., Utsumi, H.
- Journal Title
  
  Free Radic Biol Med 35
  
  Pages : 1619-1631
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Association between the expression of inducible nitric oxide synthase by chondrocytes and its nitric oxide-generating activity in adjuvant arthritis in rats.2003
- Author(s)
  Yonekura, Y., Koshiishi, I., Yamada, K., Mori, A., Uchida, S., Nakamura, T., Utsumi, H.
- Journal Title
  
  Nitric Oxide 8
  
  Pages : 164-169
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes : role of vascular NAD(P)H oxidase.2003
- Author(s)
  Inoguchi, T., Sonta, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonoda, N., Sato, N., Sekiguchi, N., Kobayashi, K., Sumimoto, H., Utsumi, H., Nawata, H.
- Journal Title
  
  J Am Soc Nephrol 14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.2003
- Author(s)
  Machida, Y., Kubota, T., Kawamura, N., Funakoshi, H., Ide, T., Utsumi, H., Li, Y.Y., Feldman, A.M., Tsutsui, H., Shimokawa, H., Takeshita, A
- Journal Title
  
  Am J Physiol Heart Circ Physiol 284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Application of in vivo ESR spectroscopy to pharmaceutical sciences : Evaluation of in vivo inhibitory mechanism of antigastric lesion drugs.2003
- Author(s)
  Kasazaki, K., Yasukawa, K., Sano, H., Yamada, K., Utsumi, H
- Journal Title
  
  Appl Magn Reson 23
  
  Pages : 585-595
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Non-invasive analysis of reactive oxygen species generated in NH_4OH-induced gastric lesions of rats using a 300 MHz in vivo ESR technique.2003
- Author(s)
  Kasazaki, K., Yasukawa, K., Sano, H., Utsumi, H.
- Journal Title
  
  Free Radic Res 37
  
  Pages : 757-766
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] In vivo electron spin resonance-computed tomography/nitroxyl probe technique for non-invasive analysis of oxidative injuries.2003
- Author(s)
  Utsumi, H., Yamada, K.
- Journal Title
  
  Arch Biochem Biophys 416
  
  Pages : 1-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes : role of vascular NAD(P)H oxidase.2003
- Author(s)
  Inoguchi, T., Sonta, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonoda, N., Sato, N., Sekiguchi, N., Kobayashi, K., Sumimoto, H., Utsumi, H., Nawata, H.
- Journal Title
  
  J Am Soc Nephrol 14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.2003
- Author(s)
  Machida, Y., Kubota, T., Kawamura, N., Funakoshi, H., Ide, T., Utsumi, H., Li, Y.Y., Feldman, A.M., Tsutsui, H., Shimokawa, H., Takeshita, A
- Journal Title
  
  Am J Physiol Heart Circ Physiol 284
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice.2003
- Author(s)
  Matsumoto, S., Koshiishi, I., Inoguchi, T., Nawata, H., Utsumi, H.
- Journal Title
  
  Free Radic Res 37
  
  Pages : 767-772
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure : Roles of oxidative stress and inflammation2002
- Author(s)
  Nakamura R, Egashira K, Machida Y, Hayashidani S, Takeya M, Utsumi H, Tsutsui H, Takeshita A
- Journal Title
  
  Circulation 106
  
  Pages : 362-367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Amyloid-beta-protein (A beta)(25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides2002
- Author(s)
  Monji, A., Utsumi, H., Ueda, T., Imoto, T., Yoshida, I., Hashioka, S., Tashiro, K., Tashiro, N
- Journal Title
  
  Life Science 70
  
  Pages : 833-841
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure : roles of oxidative stress and inflammation.2002
- Author(s)
  Nakamura, R., Egasira, K., Machida, Y., Hayashidani, S., Takeya, M., Utsumi, H., Tsutsui, H., Takeshita, A.
- Journal Title
  
  Circulation 106
  
  Pages : 362-367
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure : roles of oxidative stress and inflammation.2002
- Author(s)
  Nakamura, R., Egashira, K., Machida, Y., Hayashidani, S., Takeya, M., Utsumi, H., Tsutsui, H., Takeshita, A.
- Journal Title
  
  Circulation 106
  
  Pages : 362-367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Amyloid-beta-protein (A beta) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides2002
- Author(s)
  Monji, A., Utsumi, H., Ueda, T., Imoto, T., Yoshida, I., Hashioka, S., Tashiro, K., Tashiro, N
- Journal Title
  
  Life Science 70
  
  Pages : 833-841
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207105
[Journal Article] Noninvasive Detection of Hydroxyl Radical Generation in Lung by Diesel Exhaust Particles2001
- Author(s)
  Jin-Yi Han, Keizo Takeshita, Hideo Utsumi
- Journal Title
  
  Free Radical Biol.Med. 30
  
  Pages : 516-525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10357021
[Presentation] 臨床用DNP-MRIの開発とフリーラジカルの可視化2017
- Author(s)
  内海英雄, 増水章季, 小林竜馬, 梶原秀則, 飯倉淳, 兵藤文紀, 田平知子
- Organizer
  SEST2017
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] 臨床応用を指向したフリーラジカルイメージング・DNP-MRI装置の開発2017
- Author(s)
  内海英雄, 増水章季, 小林竜馬, 梶原秀則, 飯倉淳, 兵藤文紀, 田平知子
- Organizer
  酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] Development of New Field-cycling DNP-MRI for Free Radical Imaging2017
- Author(s)
  Hideo UTSUMI, Toshiki MASUMIZU, Ryoma KOBAYASI, Hidenori KAJIWARA, Atsushi IIKURA, Fuminori HYODO, Tomoko TAHIRA
- Organizer
  EPR2017
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] Development and Clinical Trial of Novel Field-cycling DNP-MRI for Free Radical Imaging2017
- Author(s)
  Hideo UTSUMI, Toshiki MASUMIZU, Ryoma KOBAYASHI, Utaroh Motosugi, Tatsuya Shimizu, Fuminori Hyodo, Tomoko Tahira, Hidenori KAJIWARA, Atsushi IIKURA
- Organizer
  SfRBM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] 新規フリーラジカルイメージング装置の開発と健常人介入試験2017
- Author(s)
  内海英雄, 本杉宇太郎, 清水辰哉, 田平知子
- Organizer
  日本磁気共鳴医学会
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] 臨床応用を指向したフリーラジカルイメージング・DNP-MRI装置の開発2017
- Author(s)
  内海英雄, 増水章季, 小林竜馬, 梶原秀則, 飯倉淳, 兵藤文紀, 田平知子
- Organizer
  日本磁気共鳴医学会
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] 磁石回転型Field Cycle MRIにおけるEddy Currentの効果と補正2016
- Author(s)
  小林　竜馬、内海　英雄
- Organizer
  日本磁気共鳴医学会
- Place of Presentation
  大宮ソニックシティ(埼玉県大宮)
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] T1強調撮像のための磁石回転型Field cycle MRIの開発2016
- Author(s)
  小林　竜馬、内海　英雄
- Organizer
  応用物理学会
- Place of Presentation
  朱鷺メッセ(新潟)
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] 磁石回転による主磁場制御型ＭＲＩのＴ１強調効果2016
- Author(s)
  小林　竜馬、内海　英雄
- Organizer
  NMR討論会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-16H05113
[Presentation] DNP-MRIによるユビキノン類の分子イメージングへ向けた検討2015
- Author(s)
  江藤比奈子、兵藤文紀、中路睦子、内海英雄
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] DNP-MRIによるフラビンイメージングへ向けた検討2015
- Author(s)
  中路睦子、兵藤文紀、伊藤慎治、内海英雄
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] DNP-MRIを用いた生体レドックスの画像化2015
- Author(s)
  内海英雄
- Organizer
  システム疾患生命科学による先端医療技術開発シンポジウム
- Place of Presentation
  東京大学（東京都）
- Year and Date
  2015-02-27
- Invited
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] 生体内分子・医薬品を用いた新たな代謝イメージング法の開発2015
- Author(s)
  兵藤文紀、伊藤慎治、江藤比奈子、中路睦子、安川圭司、小林竜馬、内海英雄
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] Simultaneous and Spectroscopic Redox Molecular Imaging of Free Radical Intermediates using in DNP-MRI2014
- Author(s)
  Fuminori Hyodo, Shinji Ito, Keiji Yasukawa1, Hinako Eto, Ryoma Kobayashi and Hideo Utsumi
- Organizer
  SFRBM Seattle USA
- Place of Presentation
  シアトル（米国）
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] 磁気共鳴レドックスイメージング法の開発と応用2014
- Author(s)
  兵藤文紀、伊藤慎治、江藤比奈子、中路睦子、立花葉子、内海英雄
- Organizer
  第8回レドックス・ライフイノベーション第170委員会
- Place of Presentation
  宮崎市
- Year and Date
  2014-08-21
- Invited
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] Simultaneous and spectroscopic imaging of free radical intermediates using in vivo dynamic nuclear polarization-MRI2014
- Author(s)
  Fuminori Hyodo1, Shinji Ito1, Keiji Yasukawa1,2, Hinako Eto1, Ryoma Kobayashi1 and Hideo Utsumi
- Organizer
  SEST2014
- Place of Presentation
  奈良市
- Year and Date
  2014-11-15
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] Development of DNP-MRI for free radicals in living animals.2013
- Author(s)
  Hideo Utsumi
- Organizer
  41st Annual ISOTT Meeting & EPR 2013
- Place of Presentation
  Dartmouth College in Hanover, New Hampshire, USA
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] Development of Redox Molecular Imaging of Free Radicals in Living Animal.2013
- Author(s)
  Hideo Utsumi
- Organizer
  The 55th Rocky Mountain Conference of Magnetic Resonance
- Place of Presentation
  Crowne Plaza Hotel Denver, Colorado, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] 生体レドックスの新規画像化法2013
- Author(s)
  内海　英雄
- Organizer
  第52回電子スピンサイエンス学会年会(SEST2013)
- Place of Presentation
  さいたま市大宮区大宮ソニックシティ
- Invited
- Data Source
  KAKENHI-PROJECT-25253005
[Presentation] Overhauser-MRI を用いた生体レドックス・薬物動態のイメージング2012
- Author(s)
  内海英雄
- Organizer
  よこはま NMR 構造生物学研究会第45回ワークショップ「イメージングと創薬」
- Place of Presentation
  横浜市
- Year and Date
  2012-07-11
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] Novel Imaging OMRI for in vivo Redox2012
- Author(s)
  Hideo Utsumi
- Organizer
  Oxidative stress in congenital and acquired hemolytic anemia
- Place of Presentation
  タイ国(招待講演)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] 生体レドックスの分子イメージングと病態解析2012
- Author(s)
  内海英雄
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] 生体レドックスの分子イメージングと病態解析2012
- Author(s)
  内海英雄
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌市
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] Challenge for biomedical innovation by Redox Navigation at Kyushu University2012
- Author(s)
  Utsumi H
- Organizer
  The 10th International Symposium for Future Drug Discovery & Medical care
- Place of Presentation
  Sapporo (Invited Lecture)
- Year and Date
  2012-10-03
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] Overhauser-MRIを用いた生体レドックス・薬物動態のイメージング2012
- Author(s)
  内海英雄
- Organizer
  よこはまNMR構造生物学研究会第45回ワークショップ「イメージングと創薬」
- Place of Presentation
  横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] Challenge for biomedical innovation by Redox Navigation at Kyushu University.2012
- Author(s)
  H. Utsumi
- Organizer
  The 10th International Symposium for Future Drug Discovery & Medical care.
- Place of Presentation
  Sapporo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] Novel Imaging OMRI for in vivo Redox2012
- Author(s)
  Utsumi H
- Organizer
  Oxidative stress in congenital and acquired hemolytic anemia
- Place of Presentation
  Thailand. (Invited Lecture)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] High field OMRI scanner for Imaging in vivo redox status2011
- Author(s)
  K.Ichikawa, T.Naganuma, H.Utsumi
- Organizer
  Euromar 2011
- Place of Presentation
  Frankfurt, Germany
- Data Source
  KAKENHI-PROJECT-22249003
[Presentation] New insights into anticancer effect of green tea polyphenol epigallocatechin-3-gallate in hypoxia by metabolic profiling2010
- Author(s)
  Fujimura Y, Miura D, Hyodo F, Yasukawa K, Tachibana H, Utsumi H, Wariishi H.
- Organizer
  17 th Annual Meeting of SFRBM
- Place of Presentation
  Caribe Royale All-Suite Hotel & Convention Center, Orlando, Florida
- Data Source
  KAKENHI-PROJECT-22659111
[Presentation] Antioxidative effect of aripiprazole, a novel unique antipsychotic, via inhibiting superoxide generation from PMA-stimulated microglia2010
- Author(s)
  Kato T, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Yonaha M, Hashioka S, Han YH, Utsumi H, Kanba S
- Organizer
  CINP 2010
- Place of Presentation
  Hong Kong
- Year and Date
  2010-06-07
- Data Source
  KAKENHI-PROJECT-22249003

1. TAKESHITA Keizo (70175438)

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UTSUMI Hideo 内海 英雄

内海 秀雄 ウツミ ヒデオ

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Studies on the Development of Clinical Free Radical Imaging SystmePrincipal InvestigatorOngoing

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Development of free radical imaging using in vivo DNP-MRIPrincipal Investigator

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Imaging study of redox status in vivo in oxidative stress-associateddisease model animals using OMRIPrincipal Investigator

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Analysis of free radical reactions in diseases model animals using in vivo ESRIPrincipal Investigator

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生体ラジカル二重共鳴画像解析用共振デバイスと画像化システムの開発Principal Investigator

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Non-invasive analysis of dynamic state of reactive oxygen species in tissue and blood vessel of circulatory diseasesPrincipal Investigator

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Development of ESRI・MRI fused imaging device for oxidative stress-related diseasesPrincipal Investigator

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疾患成因に関わる活性酸素・活性窒素の無侵襲画像解析手法の開発Principal Investigator

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UTSUMI Hideo 内海英雄

内海秀雄ウツミヒデオ