NAKABEPPU Yusaku 中別府雄作

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中別府雄作

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Researcher Number	30180350
Other IDs
Affiliation (based on the past Project Information) *help	1997 – 2023: Kyushu University, Medical Institute of Bioregulation Dept.of Biochemistry, Prof, 生体防御医学研究所, 教授 2014: 九州大, 学生体防御医学研究所, 教授 2010 – 2011: 九州大学, 生体防御医学研究所, 主幹教授 2010: 九州大学, 生体防御研究所, 教授 1999: 九州大学, 生医研, 教授 … More 1992 – 1996: Medical Institute of Bioregulation, Kyushu University, 生体防御医学研究所, 助手 1993: 九州大学, 医学部, 助手 1990 – 1991: Kyushu University, Faculty of Medicine Research Associate, 医学部, 助手 1986: 九州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Risk sciences of radiation/Chemicals / Molecular biology / Neurochemistry/Neuropharmacology / Pathological medical chemistry / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Biological Sciences / Molecular biology Except Principal Investigator Molecular biology … More / Experimental pathology / Basic Section 52050:Embryonic medicine and pediatrics-related / Surgical dentistry / Neurology / Biological Sciences / Pediatrics / Risk sciences of radiation/Chemicals / Circulatory organs internal medicine / 環境影響評価(含放射線生物学) / Kidney internal medicine / Obstetrics and gynecology / General medical chemistry / epigenetics / Ophthalmology / Respiratory organ internal medicine / Tumor biology / Psychiatric science Less
Keywords	Principal Investigator 8-オキソグアニン / 活性酸素 / 8-oxoguanine / 酸化ストレス / ミトコンドリア / 細胞死 / 自然突然変異 / FosB / 神経変性 / MUTYH … More / OGG1 / MTH1 / CDK2 / 細胞周期 / 細胞複製 / △FosB / Jun / パーキンソン病 / アルツハイマー病 / 神経細胞死 / 酸化的DNA損傷 / ヌクレオチドプール / 転写調節 / Fos / 神経新生 / amyotrophic lateral sclerosis / Parkinson's disease / neurodegeneration / mitochondria / 2-hydroxyadenine / 筋萎縮性側索硬化症 / 2-ハイドロキシアデニン / DNA修復 / 脱アミノ化ヌクレオチド / 酸化ヌクレオチド / 病態モデル / 化学物質 / 環境ストレス / 放射線 / ミトコンドリアゲノム / 核ゲノム / 突然変異 / p53 / 8-oxo-dGTP / ΔFosB / mRNAの安定化 / サイクリンE / DNA複製 / ８－オキソグアニン / ミクログリア / ８-オキソグアニン / アミロイドーシス / 加齢 / ミクログリオーシス / 神経炎症応答 / 8-オキシグアニン / 慢性腎不全 / 認知症 / hippocampal neurogenesis / striatal medium spiny neuron / dopamine neuron / Reactive oxygen species / ハンチントン舞踏病 / 核 / 遣伝子改変マウス / 酸化ヌクレオチド損傷 / DNA酸化損傷 / 海馬神経新生 / 線条体中型有棘神経細胞 / ドパミン神経 / carcinogenesis / Reactive Oxigen Species / 遺伝子欠損マウス / 肺腫瘍 / 基質認識 / 発がん / Alzheimer's disease / reactive oxygen species / レクチン / 軸索輸送 / ニューロスフェロイド / SOD1 / 前初期遺伝子 / AP-1転写因子 / 遺伝子発現プロファイリング / 海馬硬化 / うつ病 / 側頭葉てんかん / 最初期遺伝子 / うつ / てんかん / 成体脳神経新生 / 選択的スプライシング / 転写 / 環境スレス / 細胞増殖阻害 / 酸化的損傷 / バイスタンダー効果 / RNA / DNA / P53 / (2)-ヒドロキシアデン / ミトコンドリアDNA / 核DNA / MSH2 / MLH1 / プログラム細胞死 / 発がん抑制 / 大腸腺腫症 / 家族性大腸腺腫症 / ノックアウトマウス / 修復 / ゲノム進化 / ゲノム多様性 / 組み換え / 一塩基多型 / siRNA / ピクノーシス / 酸化プリンヌクレオシド三リン酸 / ミトコンドリア機能障害 / 2-OH-dATP / がん抑制遺伝子 / アポトーシス / 核内転写因子 / 択一的翻訳開始 / 遺伝子多型 / 択一的スプライシング / 活性酵素 / hMTH1 / mutY / mutM / mutT / 酸素ラジカル / 遺伝子発現 / 神経細胞 / 細胞分化 / Rat3Y1 / cdc2 / cdk2 / AP-1 / サイクリン / CDC2 / エストロジェンレセプタ- / APー1 … More Except Principal Investigator 酸化ストレス / DNA修復 / 自然突然変異 / 突然変異 / pyrophosphatase / 8-oxodGTP / Saccharomyces cerevisiae / 2-OH-dATP / 8-オキソグアニン / DNA repair / OGG1 / 発がん / 細胞死 / 遺伝子改変マウス / DNA複製 / アルキル化剤 / 8-oxoguanine / oxidative stress / 活性酸素 / ミューテーター / 転写調節 / サイトカイン / アポトーシス / アルツハイマー病 / p53 / DNA修復酵素 / 選択的化学療法 / オルガノイド / てんかん / パーキンソン病 / DNA / apoptosis / necrosis / 酸化DNA損傷 / spontaneous mutation / orthotopic implantation / 細胞骨格 / 同所性移植 / MMP / 浸潤・転移 / Ki-67 / 8-oxo-guanine / Oxidative stress / 活性酵素 / alkylating agent / 転写因子 / cdk / Tumor suppressor gene / Mutation / メチルトランスフェラ-ゼ / DNA損傷 / ミトコンドリア / ヒストンメチル化 / PR-Set7 / 細胞周期 / ヒストンメチル化酵素 / エピジェネティクス / MTH1 / MUTYH / EGFR / インスリン抵抗性 / シグナル伝達 / 神経変性 / メチルトランスフェラーゼ / がん遺伝子c-erbB-2 / がん抑制遺伝子WT1 / △FosB / がん遺伝子EVI-1 / 軟部悪性腫瘍 / 蛍光標識PCR-SSCP法 / アルキル塩基高感度検出法 / 抗ヒトMGMT抗体 / Mer^-細胞 / O^6-アルキルグアニン / 視床・感覚路形成 / 皮質視床路 / Autism spectrum disorder / 視床皮質路 / 感覚過敏 / Shank3 / 自閉スペクトラム症 / autism spectrum disorder / 治療モデル / てんかん性脳症 / 治療標的 / iPS / 極性 / タンパク質複合体 / SPTAN1 / 分子シグナル / 発達性てんかん性脳症 / GNAO1 / MTH1,OGG1,MUTYH / 8-oxoG / ラパマイシン / mTOR / 神経分化 / 皮質形成異常 / 海馬歯状回 / AKT-mTOR / Crh-ACTH軸 / PI3K-AKT-mTOR / 分子経路 / Pomc / Crh-POMC(ACTH) / ノックアウトマウス / 海馬 / 治療 / PI3-AKT-mTOR経路 / 自閉症 / Pten / methyltransferase / induced mutation / gene cloning / DNA polymerase / replication fidelity / DNAポリメラーゼ / 発がんの抑制 / 遺伝子のクローニング / 遺伝情報 / アルキル科剤 / 誘導突然変異 / 遺伝子クロ-ニング / DNAポリメラ-ゼ / 複製精度 / cell death / nuclear genome / mitochondrial genome / Huntington's disease / Parkinson's disease / neurodegeneration / 損傷ヌクレオチド分解酵素 / 塩基除去修復 / 核ゲノム / ミトコンドリアゲノム / ハンチントン舞踏病 / Loss of heterozygosity(LOH) / genome instability / deamination / d1TP / pyrophosphatase活性 / 脱アミノ損傷ヌクレオチド / 酸化損傷ヌクレオチド浄化酵素 / 遺伝的不安定性 / spontaneous mutanegesis / Loss of Heterozygosity ; LOH / dITPase / 脱アミノ化 / ヌクレオチド損傷 / Loss of heterozygosity (LOH) / ゲノム不安定化 / 脱アミノ化損傷 / dITP / oral cancer / invasion・metastsis / proteomic analysis / tumor markers / 質量分析法 / 口腔癌 / プロテオーム解析 / 腫瘍マーカ / Myocyte / Cytokine / ROS / Electron transport complex / Mitochondria / Heart failure / ミトコンドア / 酸化損傷 / 心筋細胞 / 活性酸素種 / 電子伝達系 / 心不全 / pspontaneous mutation / MutT functional homologue / 2-OHdATP / 変異スペクトル / 2-oxodATP / MutTホモログ / Saccharomyces cervisiae / MutT functional homolog / MutT functionalhomoloq / cisplatin / ischemia-reperfusion injury / acute tubular necrosis / oxidative DNA damage / 虚血再潜流傷害 / ネクローシス / シスプラチン / 虚血再灌流傷害 / 急性尿細管壊死 / induced mutagenesis / mutation spectra / spontaneous tumorigenesis / oxygen radicals / 8-oxo-dGTPase / 放射線誘発突然変異 / 誘発突然変異 / 変異スペクトラム / 自然発がん / transcriptional activity / cytokine / growth factor / transcriptional factors / invasion and metastasis / squamous cell carcinoma / VEGF / 接着分子 / 浸潤転移 / 転写活性 / 増殖因子 / 扁平上皮癌 / BAX / c-fos / c-jun / Menstruation / Endometrium / Ki-17 / AP-I / FGFR / Fos / Jun / AP-1 / タモキシフェン / 子宮内膜癌 / 子宮内膜 / Carcinogenesis / Reactive oxygen / 神経細胞死 / β-オキソグアニン / 2ーOH-dATP / DNA修飾 / 8ーオキソグアニン / 癌抑制遺伝子 / O^6-methylguanine / gene targeting / repair methyltransferase / gene-defective mouse / monoclonal antibody / modified base / O^6-メチルグアニン / 遺伝子ターゲティング / 修復メチルトランスフェラーゼ / 遺伝子欠損マウス / モノクローナル抗体 / 修復塩基 / Targeting Vector / Plasmid / lambda Phage / Homologous Recombination / Gene Targeting / Targeted Mutagenesis / ネガティブ選択 / ターゲティングベクター / プラスミド / λファージ / 相同組換え / ジーンターゲティング / 標的遺伝子組換え / DNA damage / guanine / oxidation / cloning / mutation / gene / mutator / グアニン / 酸化 / クローニング / 遺伝子 / DNA Repair / DNA Replication / Oxidative Damage / 8-Oxo-dGTP / cDNA Cloning / Mutator / Spontaneous Mutation / 酸化型損傷 / 8-oxo-dGTP / cDNAクローニング / control mechanism / protein kinase / phosphorylation / cyclin / cell proliferation / cell differentiation / cell cycle / プロテインフォスファターゼ / プロテインキナーゼ / 細胞増殖制御 / 制御機構 / タンパク質キナーゼ / リン酸化 / サイクリン / 細胞増殖 / 細胞分化 / Transcriptional regulation / Growth control / Cancer cells / Tumor promoter / Tumor virus / Oncogene / Information exchange / 研究集会 / 研究室訪問 / 北米 / 研究交流 / がん研究 / 増殖制御 / がん細胞 / がん抑制遺伝子 / 発がんプロモーター / ウイルス発がん / がん遺伝子 / 研究情報交換 / Adaptive Response / Alkylating Agent / Ada Regulon / Gene Expression / Transcriptional Control / DNA Damage / DNA Repair Enzyme / DNA修復酸素 / 抗がん剤 / 突然変異の誘起 / 適応応答 / adaレギュロン / 遺伝子発現 / 肝発生 / 肝幹細胞 / 発癌 / 肝臓癌 / 癌幹細胞 / DNA酸化障害 / 糖尿病 / TFAM / 遺伝子ノックアウトマウス / set8 / ヒストンメチルトランスフェラーゼ / メチル化 / ヒストン / クロマチン / H4リジン20 / ヒストン修飾 / 染色体 / MUTHY / OGG１ / 網膜光障害 / mTOR阻害薬 / BIBW2552 / JAK1/2阻害薬 / everolimus / ｍTOR阻害薬 / 用量依存性 / gefitinib / AZD1480 / everolims / NNK / Ogg1ホモノックアウトマウス / bevacizumab / cetuximab / JAK-1/2 inhibitors / everolimus (mTOR阻害薬), / afatinib / EGFR遺伝子改変マウス / モリス水迷路 / リン酸化タウ蛋白 / 小胞体ストレス / 毒性ターン / インスリン分解酵素 / アミロイドβ / アポモルフィン / モデルマウス / 神経分子病態学 / ストレス / 癌 / がん / ゲノム / シグナル伝達と遺伝子発現 / アデノシン受容体 / c-Fos / 聴覚ミスマッチ陰性反応 / グルタミン酸 / 一酸化窒素 / ミクログリア / 分界条床核 / 扁桃体 / 双極性障害 / 精神薬理学 / 遊離ヌクレオチド損傷 / DNA酸化損傷 / 動物 / p53プロモーター / 核DNA傷害 / 神経細胞防護 / 熱ショック / 転写 / プロモーター / アミロイドβ蛋白 / 蛍光PCR-SSCP法 / 転写因子YB-1 / 平滑筋肉腫 / 尿路腫瘍 / Kid / EVI-1 / hMTH1 / APエンドヌクレアーゼ / ヒト腫瘍 / MTH1遺伝子 / ミスマッチ修復 / 遺伝子変異 / E2F4 / hMSH3 / replication error / 多型タンパク不安定性 / 遺伝子多型 / 突然変異上昇 / ミューテーター遺伝子 / Zink finger / H-ras遺伝子 / MGMT遺伝子の発現制御機構 / メチル転移酵素(MGMT) / ヒトMGMT遺伝子 / アルキル転移酵素(MGMT) / 遺伝子発現制御 / Mer^ー形質 / ヒト腫瘍細胞 / メチル転移酵素 Less

Shank3欠損マウスと患児オルガノイドを用いた視床・感覚路発達メカニズムの解析
- Principal Investigator
  
  奥園清香
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Fukuoka Dental College
  Kyushu University
A study for convergent molecular mechanisms underlying epileptic encephalopathy using cortical organoids
- Principal Investigator
  
  Sakai Yasunari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyushu University
Investigation of brain damage caused by reactive oxygen species and its defense mechanismsPrincipal Investigator
- Principal Investigator
  
  Yusaku Nakabeppu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyushu University
Development of a new translational medicine for epilepsy using the Pten-mutant mice
- Principal Investigator
  
  Sakai Yasunari
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyushu University
Implication of oxidative damage in nucleic acids and its defense mechanisms for development of brain dysfunction which may be caused by chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Nakabeppu Yusaku
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
Function of histone methyltransferase PR-set7 and its relationship to carcinogenesis
- Principal Investigator
  
  Oda Hisanobu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  National Hospital Organization, Kyushu Cancer Center
Molecular mechanism of degeneration of dopaminergic neurons caused by 8-oxoguanine
- Principal Investigator
  
  Sheng Zijing
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyushu University
Galectin-1による筋萎縮性側索硬化症の発症と進行の二面的制御Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
hTFAM improves impaired insulin signaling in Alzheimer's disease
- Principal Investigator
  
  OKA SUGAKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse
- Principal Investigator
  
  KIURA Katsuyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
Study of Pathological Mechanism in Light Induced Retinal Damage using DNA Base Excision Repair Gene Knockout Mice
- Principal Investigator
  
  OHIRA Akihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Shimane University
Analysis of chromatin function mediated by histone H4 lysine 20 methylation
- Principal Investigator
  
  ODA Hisanobu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  epigenetics
- Research Institution
  National Hospital Organization, Kyushu Cancer Center
Regulatory mechanisms of brain function by alternative splicing products of fosB genePrincipal Investigator
- Principal Investigator
  
  NAKABEPPU Yusaku
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stressPrincipal Investigator
- Principal Investigator
  
  NAKABEPPU YUSAKU
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University
環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University
Regulation of MUTYH expression by p53 plays a critical role in cell death
- Principal Investigator
  
  OKA Sugako
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University
Development of apomorphine therapy for Alzheimer disease
- Principal Investigator
  
  OHYAGI Yasumasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Genomic damage and cancer cell death caused by reactive oxygen speciesPrincipal Investigator
- Principal Investigator
  
  NAKABEPPU Yusaku
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular and phathobiological analysis of defects in quality control systems for DNA and free nucleotides by using mouse models
- Principal Investigator
  
  TSUCHIMOTO Daisuke
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyushu University
Disorder of reward circuit in bipolar disorders : integration of basic and clinical investigation
- Principal Investigator
  
  KANBA Shigenobu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kyushu University
酸化的ストレスによる細胞死と消化管がん抑制機構におけるMUTYHの働きPrincipal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Roles of the defense mechanisms against oxidative damage in nucleic acids for maintenance of brain cellsPrincipal Investigator
- Principal Investigator
  
  NAKABEPPU Yusaku
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyushu University
酸化的ストレスによる細胞死と消化管がん抑制機構におけるMUTYHの働きPrincipal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
ゲノム多型及び遺伝病の成因としての自然DNA酸化損傷とその修復機構の破綻Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular pathological analysis of defects in DNA base excision repair system using gene modified mice
- Principal Investigator
  
  TSUCHIMOTO Daisuke
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyushu University
ヒト癌におけるMTH1発現亢進の意義の解明とMTH1の発現・機能抑制法の開発Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
The sanitizing systems for endogenous nucleotide lesions, and their roles on spontaneous mutagenesis
- Principal Investigator
  
  NUNOSHIBA Tatsuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure
- Principal Investigator
  
  TSUTSUI Hiroyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  HOKKAIDO UNIVERSITY
  Kyushu University
Establishment of detectional system of individual tumor markers
- Principal Investigator
  
  MORIFUJI Masayo, 大石正道
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  KYUSHU UNIVERSITY
Study on oxidative DNA damage and repair enzyme in acute and chronic renal disease
- Principal Investigator
  
  HIRAKATA Hideki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyushu University
Implication of oxidized nucleotides in spontaneous mutation and their sanitizing systems
- Principal Investigator
  
  NUNOSHIBA Tatsuoi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
Oxidative DNA damage-induced tumorigenesis and its avoidance mechanism
- Principal Investigator
  
  TSUZUKI Teruhisa
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
アルツハイマー病の細胞内Aβ42誘導性ニューロンアポトーシス死の分子メカニズム
- Principal Investigator
  
  OHYAGI Yasumasa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Analysis of the regulated mechanisms of cell proliferation and apoptosis in the endometrium at AP-1 binding site
- Principal Investigator
  
  HACHISUGA Toru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukuoka University
The total analyses of the mechanism of the invasion and metastasis in human oral squamus cell carcinoma by the transcriptional factors
- Principal Investigator
  
  MORIFUJI Masayo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  KYUSHU UNIVERSITY
Study of Defense Mechanisms against Cellular Damage Caused by Free RadicalsPrincipal Investigator
- Principal Investigator
  
  NAKABEPPU Yusaku
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  KYUSHU UNIVERSITY
プロトオンコジーンfosBによる細胞増殖と細胞死の制御機構の解析Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
活性酸素による神経細胞死とその防御機構の解析Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
Oxygen-induced DNA damage and its repair mechamism
- Principal Investigator
  
  TSUZUKI Teruhisa
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  KYUSHU UNIVERSITY
DNA Repair Mechanisms Protecting Brain and Neuronal Cells from Damage Caused by Reactive Oxygen SpeciesPrincipal Investigator
- Principal Investigator
  
  NAKABEPPU Yusaku
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  KYUSHU UNIVERSITY
ヒト発がんにおける複製・修復遺伝子の変異
- Principal Investigator
  
  石川隆俊
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ヒトMTH1蛋白質の発現制御と突然変異抑制機能の解析Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
活性酸素による神経細胞死とその防止機構の解析Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Repair of alkylation DNA damage
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  Fukuoka Dental College
転写制御遺伝子群の発癌への関与
- Principal Investigator
  
  林健志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
哺乳動物における酸素ラジカルによる自然突然変異とその抑制機構Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Development of an Effecient System for Gene Targeting
- Principal Investigator
  
  TSUZUKI Teruhisa
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
転写制御遺伝子群の発癌への関与
- Principal Investigator
  
  林健志
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Active Oxygen-induced DNA Damage and its Repair Mechanisms
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYUSHU UNIVERSITY
ΔFosBによる細胞複製の制御Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
転写制御遺伝子群の発癌への関与
- Principal Investigator
  
  林健志
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
fosB遺伝子による細胞のがん化と遺伝子発現制御Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Oxygen-induced DNA Damage and its Repair Mechanisms
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYUSHU UNIVERSITY
△FosBによる細胞の癌化と遺伝子発現Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
Fos,Junによる細胞複製の制御Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
FosBおよび△FosBによる細胞分化の制御Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
Molecular Mechanisms of Differentiation and Proliferation Switches
- Principal Investigator
  
  KATSURA Isao, 登田隆
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Institute of Genetics
  Kyoto University
Fos,Junの標的遺伝子の検索Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
Fos,Junによる細胞複製の制御Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
O^6ーアルキルグアニンーアルキル転移酵素の制がんと発がんにおける役割
- Principal Investigator
  
  池永満生
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
Jun/Fos複合体(APー1)による細胞複製の制御Principal Investigator
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
O^6-アルキルグアニン-アルキル転移酵素の制がんと発がんにおける役割
- Principal Investigator
  
  池永満生
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
O^6-アルキルグアニン-アルキル転移酵素の制がんと発がんにおける役割
- Principal Investigator
  
  池永満生
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
Information Exchange on Cancer Research with North American Countries.
- Principal Investigator
  
  YAMAGUCHI Nobuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute of Medical Science, University of Tokyo
Molecular mechanisms of the adaptive response to alkylating agents
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYUSHU UNIVERSITY
Maintenance of Genetic Information and Mutagenesis Mechanisms
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1986 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyushu University

[Book] Diabetes Mellitus: A risk factor for Alzheimer's Disease2019
- Author(s)
  Nakabeppu Y and Ninomiya T. (Editors)
- Total Pages
  248
- Publisher
  Springer Singapore
- ISBN
  9789811335396
- Data Source
  KAKENHI-PROJECT-17H01391
[Book] Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases. in The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design2017
- Author(s)
  Y Nakabeppu
- Total Pages
  34
- Publisher
  World Scientific Publishing Co., Pte. Ltd. Singapore
- Data Source
  KAKENHI-PROJECT-15K15085
[Book] 酸化ストレスの医学改訂第2版2014
- Author(s)
  中別府雄作
- Total Pages
  456
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-22221004
[Book] 遺伝子変異の機構2014
- Author(s)
  中別府雄作
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22221004
[Book] Ganglion Cells: Morphology, Functional Development and Role in Disease2014
- Author(s)
  Sango K, Niimi N, Tsukamoto M, Utsunomiya K, Sakumi K, Nakabeppu Y, Kadoya T, Horie H
- Total Pages
  158
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PUBLICLY-25110724
[Book] 図説分子病態学５版2014
- Author(s)
  中別府雄作
- Total Pages
  408
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22221004
[Book] Ganglion Cells: Morphology, Functional Development and Role in Disease2014
- Author(s)
  Sango K, Niimi N, Tsukamoto M, Utsunomiya K, Sakumi K, Nakabeppu Y, Kadoya T, Horie H
- Total Pages
  158
- Publisher
  Nova Science Publishers, Inc
- Data Source
  KAKENHI-PROJECT-22221004
[Book] Ganglion Cells: Morphology, Functional Development and Role in Disease2014
- Author(s)
  Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T., and Horie, H.
- Total Pages
  139
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PUBLICLY-25110724
[Book] Ganglion Cells: Morphology, Functional Development and Role in Disease2014
- Author(s)
  Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T., and Horie, H.
- Total Pages
  139
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-22221004
[Book] Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage2009
- Author(s)
  Oka, S., Ohno, M., Nakabeppu, Y.
- Data Source
  KAKENHI-PROJECT-20013034
[Book] in mitochondrial DNA by immunofluorescence method. Methods Mol Biol2009
- Author(s)
  Ohno, M., Oka, S., Nakabeppu, Y.
- Data Source
  KAKENHI-PROJECT-20013034
[Book] 遺伝子変異の機構図説分子病態学 4版(一瀬白帝, 鈴木宏治編集)2008
- Author(s)
  中別府雄作
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-18013038
[Book] 遺伝子変異の機構図説分子病態学4版(一瀬白帝, 鈴木宏治編集)2008
- Author(s)
  中別府雄作
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Book] Prvention of the mutagenecity and cytotoxicity of oxidized pruine nucleotides. In Evands, M.D. and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids.2007
- Author(s)
  Nakabeppu, Y., et. al.
- Publisher
  Springer, Austin, TX
- Data Source
  KAKENHI-PROJECT-18013038
[Book] DNA Replication and Transcription:In Meyrers RA(eds), Genomics and Genetics:From Molecular Details to Analysis and Techniques.2007
- Author(s)
  Nakabeppu Y, et. al.
- Publisher
  Wiley-VCH Verlag GmbH and Co.,Weinheim,Germany
- Data Source
  KAKENHI-PROJECT-19390114
[Book] DNA Replication and Transcription. (From Molecular Details to Analysis and Techniques)(In : Meyers RA, editor. Genomics and Genetics)2007
- Author(s)
  Nakabeppu Y, Maki H, Sekiguchi. M
- Total Pages
  27
- Publisher
  Wiley-VCH Verlag GmbH ＆ Co., Weinheim, Germany
- Data Source
  KAKENHI-PROJECT-18013038
[Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, In Oxidative Damage to Nucleic Acids2007
- Author(s)
  Nakabeppu, Y., Behmanesh, M., Yamaguchi, H., Yoshimura, D., Sakumi, K
- Total Pages
  14
- Publisher
  Landes Bioscience/Eurekah, Georgetown, TX. USA
- Data Source
  KAKENHI-PROJECT-18013038
[Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides.In Evans, M.D.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids.2007
- Author(s)
  Nakabeppu Y, et. al.
- Publisher
  Springer,Austin,TX
- Data Source
  KAKENHI-PROJECT-19390114
[Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides.In Evans, MD.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids2007
- Author(s)
  Nakabeppu Y, et. al.
- Publisher
  Springer,Austin,TX
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Book] DNA Replication and Transcription:In Meyrers RA(eds), Genomics and Genetics:From Molecular Details to Analysis and Techniques.2007
- Author(s)
  Nakabeppu Y, et. al.
- Publisher
  Wiley-VCH Verlag GmbH and Co., Weinheim, Germany
- Data Source
  KAKENHI-PROJECT-18300124
[Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, In Oxidative Damage to Nucleic Acids2007
- Author(s)
  Nakabeppu, Y., Behmanesh, M., Yamaguchi, H., Yoshimura, D., Sakumi, K
- Total Pages
  14
- Publisher
  Landes Bioscience/Eurekah, Georgetown, TX USA
- Data Source
  KAKENHI-PROJECT-18300124
[Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nuckeotides,In Oxidative Damage to Nucleic Acids.2007
- Author(s)
  Nakabeppu, Y., Behmanesh, M., Yamaguchi, H., Yoshimura, D., Sakumi, K.
- Total Pages
  14
- Publisher
  Georgetown,TX. : Landes Bioscience/Eurekah
- Data Source
  KAKENHI-PROJECT-16390119
[Book] DNA Replication and Transcription: In Meyrers RA(eds), Genomics and Genetics: From Molecular Details to Analysis and Techniques2007
- Author(s)
  Nakabeppu Y, et. al.
- Publisher
  Wiley-VCH Verlag GmbH and Co.,Weinheim,Germany
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Book] DNA Replication and Transcription: In Meyrers RA(eds), Genomics and Genetics: From Molecular Details to Analysis and Techniques.2007
- Author(s)
  Nakabeppu, Y., et. al.
- Publisher
  Wiley-VCH Verlag GmbH and Co., Weinheim, Germany
- Data Source
  KAKENHI-PROJECT-18013038
[Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides. In Evans, M.D.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids.2007
- Author(s)
  Nakabeppu Y, et. al.
- Publisher
  Springer,Austin,TX
- Data Source
  KAKENHI-PROJECT-18300124
[Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, in Oxidative Damage to Nucleic Acids.2007
- Author(s)
  Nakabeppu, Y. et al.
- Publisher
  Georgetown, TX. : Landes Bioscience / Eurekah (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice2023
- Author(s)
  Okuzono Sayaka、Fujii Fumihiko、Matsushita Yuki、Setoyama Daiki、Shinmyo Yohei、Taira Ryoji、Yonemoto Kousuke、Akamine Satoshi、Motomura Yoshitomo、Sanefuji Masafumi、Sakurai Takeshi、Kawasaki Hiroshi、Han Kihoon、Kato Takahiro A.、Torisu Hiroyuki、Kang Dongchon、Nakabeppu Yusaku、Sakai Yasunari、Ohga Shouichi
- Journal Title
  
  Neuroscience Research
  
  Volume: in press Pages: 13-19
- DOI
  10.1016/j.neures.2023.03.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08182, KAKENHI-PUBLICLY-20H05056, KAKENHI-PROJECT-21K07865, KAKENHI-PROJECT-21K19306, KAKENHI-PROJECT-21K19307, KAKENHI-PROJECT-20H03338, KAKENHI-PROJECT-20H03351, KAKENHI-PUBLICLY-23H04156, KAKENHI-PROJECT-23K27277
[Journal Article] OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model2020
- Author(s)
  Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Lloyd, R. S., and Sampath, H.
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 1 Pages: e0227501-e0227501
- DOI
  10.1371/journal.pone.0227501
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in Ogg1-/- mice2020
- Author(s)
  Kvandova, M., Filippou, K., Steven, S., Oelze, M., Kalinovic, S., Stamm, P., Frenis, K., Vujacic-Mirski, K., Sakumi, K., Nakabeppu, Y., Bagheri Hosseinabadi, M., Dovinova, I., Epe, B., Munzel, T., Kroller-Schon, S. and Daiber, A.
- Journal Title
  
  Free Radical Research
  
  Volume: in press Issue: 4 Pages: 280-292
- DOI
  10.1080/10715762.2020.1754410
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice2020
- Author(s)
  Funahashi Satomi、Okazaki Yasumasa、Akatsuka Shinya、Takahashi Takashi、Sakumi Kunihiko、Nakabeppu Yusaku、Toyokuni Shinya
- Journal Title
  
  Free Radical Research
  
  Volume: N/A Issue: 2-3 Pages: 1-231
- DOI
  10.1080/10715762.2020.1743285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05462, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-20K07588, KAKENHI-PROJECT-16H02468, KAKENHI-PUBLICLY-20H05502
[Journal Article] Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer's Disease Brain2019
- Author(s)
  Nakabeppu, Y.
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 1128 Pages: 27-44
- DOI
  10.1007/978-981-13-3540-2_3
- ISBN
  9789811335396, 9789811335402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Origins of Brain Insulin and Its Function2019
- Author(s)
  Nakabeppu, Y.
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 1128 Pages: 1-11
- DOI
  10.1007/978-981-13-3540-2_1
- ISBN
  9789811335396, 9789811335402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice2019
- Author(s)
  Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y., and Wang, Y.
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 143 Pages: 482-493
- DOI
  10.1016/j.freeradbiomed.2019.09.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes2019
- Author(s)
  Haruyama, N., Sakumi, K., Katogi, A., Tsuchimoto, D., De Luca, G., Bignami, M., and Nakabeppu, Y.
- Journal Title
  
  Progress in Neurobiology
  
  Volume: 180 Pages: 101613-101613
- DOI
  10.1016/j.pneurobio.2019.04.002
- NAID
  120006839234
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis2018
- Author(s)
  Hommyo Reiji、Suzuki Satoshi O.、Abolhassani Nona、Hamasaki Hideomi、Shijo Masahiro、Maeda Norihisa、Honda Hiroyuki、Nakabeppu Yusaku、Iwaki Toru
- Journal Title
  
  Neuropathology
  
  Volume: － Issue: 3 Pages: 247-259
- DOI
  10.1111/neup.12466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-17J01738, KAKENHI-PROJECT-26290017
[Journal Article] 活性酸素による核酸の酸化と老化関連疾患－発がんから神経変性まで－2018
- Author(s)
  2.中別府雄作
- Journal Title
  
  実験医学
  
  Volume: 36 Pages: 161-170
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.2018
- Author(s)
  Izumi H, Shinoda Y, Saito T, Saido TC, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K.
- Journal Title
  
  Neuroscience.
  
  Volume: 377 Pages: 87-97
- DOI
  10.1016/j.neuroscience.2018.02.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15456, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-16J02855, KAKENHI-PROJECT-16K20909, KAKENHI-PROJECT-16H05219
[Journal Article] A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.2018
- Author(s)
  Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI.
- Journal Title
  
  Annals of Neurology
  
  Volume: 84 Issue: 2 Pages: 208-224
- DOI
  10.1002/ana.25279
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11477, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-17K19663, KAKENHI-PROJECT-17H01391
[Journal Article] Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation2017
- Author(s)
  Kajitani Kosuke、Yanagimoto Kazuyuki、Nakabeppu Yusaku
- Journal Title
  
  Psychopharmacology
  
  Volume: 234 Issue: 19 Pages: 2919-2927
- DOI
  10.1007/s00213-017-4683-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.2017
- Author(s)
  Li GH, Akatsuka S, Chew SH, Jiang L, Nishiyama T, Sakamoto A, Takahashi T, Futakuchi M, Suzuki H, Sakumi K, Nakabeppu Y, Toyokuni S.
- Journal Title
  
  Pathol Int.
  
  Volume: 67 Issue: 11 Pages: 564-574
- DOI
  10.1111/pin.12598
- NAID
  120006382249
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19913, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-15K06837, KAKENHI-PROJECT-16H02468
[Journal Article] Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi2017
- Author(s)
  Shijo Masahiro、Honda Hiroyuki、Suzuki Satoshi O.、Hamasaki Hideomi、Hokama Masaaki、Abolhassani Nona、Nakabeppu Yusaku、Ninomiya Toshiharu、Kitazono Takanari、Iwaki Toru
- Journal Title
  
  Brain Pathology
  
  Volume: 28 Issue: 1 Pages: 58-71
- DOI
  10.1111/bpa.12475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290017, KAKENHI-PROJECT-17H01391
[Journal Article] 2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway2017
- Author(s)
  Asada Shinji、Ohta Eiko、Akimoto Yoriko、Abolhassani Nona、Tsuchimoto Daisuke、Nakabeppu Yusaku
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6528-6528
- DOI
  10.1038/s41598-017-06636-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] 8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle2017
- Author(s)
  Vartanian Vladimir、Tumova Jana、Dobrzyn Pawel、Dobrzyn Agnieszka、Nakabeppu Yusaku、Lloyd R. Stephen、Sampath Harini
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 7 Pages: e0181687-e0181687
- DOI
  10.1371/journal.pone.0181687
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice.2017
- Author(s)
  Yoshii Y, Inoue T, Sato T, Iwasaki Y, Kojima M, Yada T, Nakabeppu Y, Noda M.
- Journal Title
  
  Neurochem Res
  
  Volume: 42(9) Issue: 9 Pages: 2658-2665
- DOI
  10.1007/s11064-017-2281-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08276, KAKENHI-PROJECT-17H01391
[Journal Article] Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes2017
- Author(s)
  Seifermann Marco、Ulges Alexander、Bopp Tobias、Melcea Svetlana、Sch?fer Andrea、Oka Sugako、Nakabeppu Yusaku、Klungland Arne、Niehrs Christof、Epe Bernd
- Journal Title
  
  DNA Repair
  
  Volume: 58 Pages: 13-20
- DOI
  10.1016/j.dnarep.2017.08.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain.2017
- Author(s)
  Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y.
- Journal Title
  
  Mech Ageing Dev.
  
  Volume: 161 Pages: 95-104
- DOI
  10.1016/j.mad.2016.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290017, KAKENHI-PROJECT-26460490, KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-17H01391
[Journal Article] Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation2017
- Author(s)
  Castillo Erika、Leon Julio、Mazzei Guianfranco、Abolhassani Nona、Haruyama Naoki、Saito Takashi、Saido Takaomi、Hokama Masaaki、Iwaki Toru、Ohara Tomoyuki、Ninomiya Toshiharu、Kiyohara Yutaka、Sakumi Kunihiko、LaFerla Frank M.、Nakabeppu Yusaku
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 17762-17762
- DOI
  10.1038/s41598-017-17999-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290017, KAKENHI-PROJECT-17H01391
[Journal Article] Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer2017
- Author(s)
  Fujishita Takatoshi、Okamoto Tatsuro、Akamine Takaki、Takamori Shinkichi、Takada Kazuki、Katsura Masakazu、Toyokawa Goji、Shoji Fumihiro、Shimokawa Mototsugu、Oda Yoshinao、Nakabeppu Yusaku、Maehara Yoshihiko
- Journal Title
  
  Lung Cancer
  
  Volume: 109 Pages: 52-57
- DOI
  10.1016/j.lungcan.2017.04.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse2017
- Author(s)
  Chikama Koji、Yamada Hidetaka、Tsukamoto Tatsuo、Kajitani Kosuke、Nakabeppu Yusaku、Uchimura Naohisa
- Journal Title
  
  Brain Research
  
  Volume: 1676 Pages: 77-82
- DOI
  10.1016/j.brainres.2017.09.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice.2016
- Author(s)
  Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.
- Journal Title
  
  Sci Rep
  
  Volume: 未 Issue: 1 Pages: 22991-22991
- DOI
  10.1038/srep22991
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09655, KAKENHI-PROJECT-24240120, KAKENHI-PROJECT-26893189, KAKENHI-PROJECT-15K09624, KAKENHI-PROJECT-16K08626, KAKENHI-PROJECT-26640081
[Journal Article] Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.2016
- Author(s)
  S. Oka, J. Leon, K. Sakumi, T. Ide, D. Kang, F.M. LaFerla, and Y. Nakabeppu
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 37889-37889
- DOI
  10.1038/srep37889
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-15K15085
[Journal Article] 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions2016
- Author(s)
  Julio, Leon, Sakumi Kunihiko, Castillo Erika, Sheng Zijing, Oka Sugako, Nakabeppu Yusaku.
- Journal Title
  
  Scientific Reports
  
  Volume: 25 Issue: 1 Pages: 22086-22086
- DOI
  10.1038/srep22086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460490, KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-25461281
[Journal Article] MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?2016
- Author(s)
  Y. Nakabeppu, E. Ohta, N. Abolhassani
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 印刷中 Pages: 151-158
- DOI
  10.1016/j.freeradbiomed.2016.11.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-17H01391
[Journal Article] ゲノムに蓄積した8-oxoguanine に起因する病態とその防御機構－発がんから神経変性まで－2016
- Author(s)
  中別府雄作
- Journal Title
  
  基礎老化研究
  
  Volume: 40 Pages: 23-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15085
[Journal Article] アルツハイマー病におけるインスリン産生低下とミトコンドリア機能不全2015
- Author(s)
  中別府雄作
- Journal Title
  
  細胞工学
  
  Volume: 34 Pages: 389-391
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] アルツハイマー病は脳の糖尿病!?2015
- Author(s)
  中別府雄作
- Journal Title
  
  NHKきょうの健康
  
  Volume: 325 Pages: 94-97
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.2015
- Author(s)
  Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 127 Issue: 4 Pages: 446-455
- DOI
  10.1016/j.jphs.2015.03.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-26340025, KAKENHI-PUBLICLY-15H00897, KAKENHI-PLANNED-24108009, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-25460334
[Journal Article] 脳内酸化ストレス2014
- Author(s)
  中別府雄作
- Journal Title
  
  分子精神医学
  
  Volume: 14 Pages: 200-201
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] 8-oxoguanine causes spontaneous de novo germline mutations in mice.2014
- Author(s)
  Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., and Nakabeppu, Y.
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 4689-4689
- DOI
  10.1038/srep04689
- NAID
  120005703609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PLANNED-24108009, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-25241016
[Journal Article] Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation2014
- Author(s)
  Stavnezer J, Linehan EK, Thompson MR, Habboub G, Ucher AJ, Kadungure T, Tsuchimoto D, Nakabeppu Y
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 111 Issue: 25 Pages: 9217-9222
- DOI
  10.1073/pnas.1405590111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Characterization of galectin-1-positive cells in the mouse hippocampus.2014
- Author(s)
  Kajitani, K., Kobayakawa, Y., Nomaru, H., Kadoya, T., Horie, H., and Nakabeppu, Y.
- Journal Title
  
  Neuroreport
  
  Volume: 25 Issue: 3 Pages: 171-176
- DOI
  10.1097/wnr.0000000000000068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PUBLICLY-25110724, KAKENHI-PROJECT-25870494
[Journal Article] Altered expression of diabetes-related genes in Alzheimer's disease brains: the hisayama study2014
- Author(s)
  Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y
- Journal Title
  
  Cereb Cortex
  
  Volume: 24 Issue: 9 Pages: 2476-2488
- DOI
  10.1093/cercor/bht101
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24591720, KAKENHI-PROJECT-25461281
[Journal Article] International Symposium on "Germline Mutagenesis and Biodiversification"2014
- Author(s)
  Uchimura A, Hara Y, Gondo Y, Nakabeppu Y
- Journal Title
  
  Genes Genet Syst
  
  Volume: 89 Pages: 93-95
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells2014
- Author(s)
  Nakabeppu Y
- Journal Title
  
  Int J Mol Sci
  
  Volume: 15 Issue: 7 Pages: 12543-12557
- DOI
  10.3390/ijms150712543
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage.2014
- Author(s)
  Jalland, C.M., Benestad, S.L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjoras, M., and Tranulis, M.A.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 68 Pages: 1-7
- DOI
  10.1016/j.freeradbiomed.2013.11.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Galectin-1 deficiency improves axonal swelling of motor neurons in SOD1 transgenic mice.2014
- Author(s)
  Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J.I., and Nakabeppu, Y.
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: N/A Issue: 2 Pages: 227-244
- DOI
  10.1111/nan.12123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PUBLICLY-25110724, KAKENHI-PROJECT-25293204, KAKENHI-PROJECT-25870494
[Journal Article] Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia.2014
- Author(s)
  Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y.N., Kajitani, K., Tsuchimoto, D., Nestler, E.J., and Nakabeppu, Y.
- Journal Title
  
  Glia
  
  Volume: N/A Issue: 8 Pages: 1284-1298
- DOI
  10.1002/glia.22680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24591735, KAKENHI-PROJECT-25870494
[Journal Article] Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes.2014
- Author(s)
  Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K., and Kitazono, T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 34 Issue: 1 Pages: 44-51
- DOI
  10.1161/atvbaha.113.302214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23591195
[Journal Article] Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice2014
- Author(s)
  Isoda T, Nakatsu Y, Yamauchi K, Piao J, Yao T, Honda H, Nakabeppu Y, Tsuzuki T
- Journal Title
  
  Int J Biol Sci
  
  Volume: 10 Issue: 8 Pages: 940-947
- DOI
  10.7150/ijbs.9241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-26340025
[Journal Article] Inhibitory effects of dietary Spirulina platensis on UVB induced skin inflammatory responses and carcinogenesis.2014
- Author(s)
  Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y., and Nishigori, C.
- Journal Title
  
  J Invest Dermatol
  
  Volume: N/A Issue: 10 Pages: 2610-2619
- DOI
  10.1038/jid.2014.188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25461281, KAKENHI-PROJECT-25461668
[Journal Article] Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells2014
- Author(s)
  Guikema JE, Linehan EK, Esa N, Tsuchimoto D, Nakabeppu Y, Woodland RT, Schrader CE
- Journal Title
  
  J Immunol
  
  Volume: 193 Pages: 931-939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death2014
- Author(s)
  Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y
- Journal Title
  
  Oncogenesis
  
  Volume: 3 Issue: 10 Pages: 1-10
- DOI
  10.1038/oncsis.2014.35
- NAID
  120005703608
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25461281
[Journal Article] DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3beta and expressions of cyclin D1 and TCF7L2 in cancer model mice.2014
- Author(s)
  Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., and Sasaguri, T.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: N/A Issue: 3 Pages: 340-348
- DOI
  10.1016/j.bcp.2014.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-26340025
[Journal Article] Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains.2014
- Author(s)
  Hamasaki, H., Honda, H., Suzuki, S.O., Hokama, M., Kiyohara, Y., Nakabeppu, Y., and Iwaki, T.
- Journal Title
  
  Neuropathology
  
  Volume: N/A Issue: 3 Pages: 284-290
- DOI
  10.1111/neup.12095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24650186, KAKENHI-PROJECT-25430050, KAKENHI-PROJECT-26290017
[Journal Article] GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons.2013
- Author(s)
  Takaku S, Yanagisawa H, Watabe K, Horie H, Kadoya T, Sakumi K, Nakabeppu Y, Poirier F, Sango K.
- Journal Title
  
  Neurochem Int
  
  Volume: 62 Issue: 3 Pages: 330-339
- DOI
  10.1016/j.neuint.2013.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22500324, KAKENHI-PROJECT-24500428, KAKENHI-PROJECT-25430056
[Journal Article] Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.2013
- Author(s)
  Matsumoto, A., Yamafuji, M., Tachibana, T., Nakabeppu, Y., Noda, M., and Nakaya, H.
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 3273-3273
- DOI
  10.1038/srep03273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24659111
[Journal Article] Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus.2013
- Author(s)
  Sakai, Y., Ohkubo, K., Matsushita, Y., Akamine, S., Ishizaki, Y., Torisu, H., Ihara, K., Sanefuji, M., Kim, M.S., Lee, K.U., Shaw, C.A., Lim, J., Nakabeppu, Y., and Hara, T.
- Journal Title
  
  Eur J Med Genet
  
  Volume: 59 Issue: 9 Pages: 475-783
- DOI
  10.1016/j.ejmg.2013.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23591503, KAKENHI-PROJECT-24650199
[Journal Article] fosB-Null Mice Display Impaired Adult Hlppocampal Neurogenesis and Spontaneous Epilepsy2013
- Author(s)
  Yutsudo, N, et. al.
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 38 Issue: 5 Pages: 895-906
- DOI
  10.1038/npp.2012.260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23500498, KAKENHI-PROJECT-23657116, KAKENHI-PROJECT-24591299, KAKENHI-PROJECT-24591735
[Journal Article] Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice.2013
- Author(s)
  suji, H., Ishii-Ohba, H., Shiomi, T., Shiomi, N., Katsube, T., Mori, M., Nenoi, M., Ohno, M., Yoshimura, D., Oka, S., Nakabeppu, Y., Tatsumi, K., Muto, M., and Sado, T.
- Journal Title
  
  J Radiat Res
  
  Volume: 54 Issue: 3 Pages: 453-466
- DOI
  10.1093/jrr/rrs128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Altered expression of diabetes-related genes in Alzheimer’s disease brains: The Hisayama study2013
- Author(s)
  Hokama, M., S. Oka, J. Leon, T. Ninomiya, H. Honda, K. Sasaki, T. Iwaki, T. Ohara, T. Sasaki, F.M. LaFerla, Y. Kiyohara, and Y. Nakabeppu.
- Journal Title
  
  Cereb Cortex
  
  Volume: 23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] 核酸の酸化損傷に起因する神経変性の分子機序2013
- Author(s)
  中別府雄作
- Journal Title
  
  医学のあゆみ
  
  Volume: 24 Pages: 961-968
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus.2013
- Author(s)
  Koga Y, Inazato M, Nakamura T, Hashikawa C, Chirifu M, Michi A, Yamashita T, Toma S, Kuniyasu A, Ikemizu S, Nakabeppu Y, Yamagata Y.
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun
  
  Volume: 69(Pt 1) Issue: 1 Pages: 45-48
- DOI
  10.1107/s1744309112048002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23390027, KAKENHI-PROJECT-23659025, KAKENHI-PROJECT-23790052, KAKENHI-PROJECT-25440031, KAKENHI-PLANNED-22131007, KAKENHI-PUBLICLY-23121523, KAKENHI-PUBLICLY-24113719
[Journal Article] Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes.2012
- Author(s)
  Fujita K, Yamafuji M, Nakabeppu Y, Noda M.
- Journal Title
  
  Oxid Med Cell Longev
  
  Volume: 2012 Pages: 324256-324256
- DOI
  10.1155/2012/324256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22590084
[Journal Article] Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype.2012
- Author(s)
  Yogianti F, Kunisada M, Ono R, Sakumi K, Nakabeppu Y, Nishigori C.
- Journal Title
  
  Mutagenesis
  
  Volume: 26 Issue: 6 Pages: 637-643
- DOI
  10.1093/mutage/ges029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.2012
- Author(s)
  Sheng, Z., et. al.
- Journal Title
  
  The Journal of clinical investigation
  
  Volume: 122 Issue: 12 Pages: 4344-4361
- DOI
  10.1172/jci65053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004
[Journal Article] MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration.2012
- Author(s)
  Murakami Y, Ikeda Y, Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T.
- Journal Title
  
  Am J Pathol
  
  Volume: 181 Issue: 4 Pages: 1378-1386
- DOI
  10.1016/j.ajpath.2012.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24249083
[Journal Article] 8-Oxoguanine causes neurodegeneration during Mutyh-mediated DNA base excision repair2012
- Author(s)
  Sheng Z, Oka S, Tsuchimoto D, Abolhassani N, Nomaru H, Sakumi K, Yamada H, Nakabeppu Y
- Journal Title
  
  J Clin Invest
  
  Volume: 12 Pages: 4344-4361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501014
[Journal Article] 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction.2012
- Author(s)
  Sampath H, Vartanian V, Rollins MR, Sakumi K, Nakabeppu Y, Lloyd RS.
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 12 Pages: e51697-e51697
- DOI
  10.1371/journal.pone.0051697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration2012
- Author(s)
  Murakami Y, Ikeda Y, Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T
- Journal Title
  
  Am J Pathol
  
  Volume: 181(4) Pages: 1378-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501014
[Journal Article] ニトロソ化ストレスによるイノシン三リン酸の生成と細胞応答2011
- Author(s)
  作見邦彦, 土本大介, 中別府雄作
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 175-180
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice2011
- Author(s)
  Tsuzuki T, Piao JS, Isoda T, Sakumi K, Nakabeppu Y, Nakatsu Y
- Journal Title
  
  Health Phys
  
  Volume: 100 Pages: 293-294
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] A Role for SNX1 in the Regulation of EGF-Dependent Phosphorylated EGFR Endocytosis Via the Early/Late Endocytic Pathway in a Gefitinib-Sensitive Human Lung Cancer Cells2011
- Author(s)
  Nishimura Y, Yoshioka K, Takiguchi S, Bereczky B, Nakabeppu Y, Itoh K
- Journal Title
  
  Curr.Signal Transduct.Ther.
  
  Volume: 6 Issue: 3 Pages: 383-395
- DOI
  10.2174/157436211797484047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Cancer-Related PRUNE2 Protein Is Associated with Nucleotides and Is Highly Expressed in Mature Nerve Tissues.2011
- Author(s)
  Iwama, E., D.Tsuchimoto, T.Iyama, K.Sakumi, A.Nakagawara, K.Takayama, Y.Nakanishi, Y.Nakabeppu.
- Journal Title
  
  J Mol Neurosci.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Nucleotides function as endogenous chemical sensors for oxidative stess signaling.2011
- Author(s)
  Ihara, H., T.Sawa, Y.Nakabeppu, T.Akaike.
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: 48 Pages: 33-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] FosB Is Essential for the Enhancement of Stress Tolerance and Antagonizes Locomotor Sensitization by ΔFosB2011
- Author(s)
  Ohnishi YN, et.al.
- Journal Title
  
  Biological Psychiatry
  
  Volume: 70-5 Issue: 5 Pages: 487-495
- DOI
  10.1016/j.biopsych.2011.04.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23657116
[Journal Article] Apurinic/Apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.2011
- Author(s)
  Guikema, J.E., R.M.Gerstein, E.K.Linehan, E.K.Cloherty, E.Evan-Browning, D.Tsuchimoto, Y.Nakabeppu, C.E.Schrader.
- Journal Title
  
  J Immunol
  
  Volume: 186 Pages: 1943-1950
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Therapeutic effects of hydrogen in animal models of Parkinson's disease2011
- Author(s)
  Fujita, et al
- Journal Title
  
  Parkinson's disease
  
  Volume: 176 Pages: 307875-307875
- DOI
  10.4061/2011/307875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03325, KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22590084
[Journal Article] A DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis.2011
- Author(s)
  Oka, S., Y.Nakabeppu.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 677-682
- NAID
  10029291748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis2011
- Author(s)
  Oka S, Nakabeppu Y
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 4 Pages: 677-682
- DOI
  10.1111/j.1349-7006.2011.01869.x
- NAID
  10029291748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22501014
[Journal Article] Increased expression of versican in the inflammatory response to UVB-and reactive oxygen species-induced skin tumorigenesis2011
- Author(s)
  Kunisada M, Yogianti F, Sakumi K, Ono R, Nakabeppu Y, Nishigori C
- Journal Title
  
  Am J Pathol
  
  Volume: 176 Issue: 6 Pages: 3056-3065
- DOI
  10.1016/j.ajpath.2011.08.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer.2010
- Author(s)
  Goto, M., K.Shinmura, Y.Nakabeppu, H.Tao, H.Yamada, T.Tsuneyoshi, H.Sugimura.
- Journal Title
  
  Hum Mutat
  
  Volume: 31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1.2010
- Author(s)
  Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E, Lord Cj, Ashworth A.
- Journal Title
  
  Cancer Cell 17
  
  Pages: 235-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] NUDT16 is a (deoxy) inosine diphosphatase, and its deficiency induces accumulation of single strand breaks in nuclear DNA and growth arrest2010
- Author(s)
  Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y.
- Journal Title
  
  Nucleic Acids Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.2010
- Author(s)
  Nakabeppu Y, Oka S, Sheng Z, Tsuchimoto D, Sakumi K
- Journal Title
  
  Mutation Res. inpress
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals2010
- Author(s)
  Abolhassani N, Iyama T, Tsuchimoto D(共同責任著者), Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y(共同責任著者)
- Journal Title
  
  Nucleic Acids Res. 15
- NAID
  120005227421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.2010
- Author(s)
  Nakabeppu, Y., S.Oka, Z.Sheng, D.Tsuchimoto, K.Sakumi.
- Journal Title
  
  Mutat Res
  
  Volume: 703 Pages: 51-58
- NAID
  120005227112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] A comprehensive screening system for damaged nucleotide-binding proteins.2010
- Author(s)
  Tsuchimoto, D., T.Iyama, M.Nonaka, N.Abolhassani, E.Ohta, K.Sakumi, Y.Nakabeppu.
- Journal Title
  
  Mutat Res
  
  Volume: 703 Pages: 37-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single strand breaks in nuclear DNA with growth arrest2010
- Author(s)
  Iyama T, Abolhassani N, Tsuchimoto D (責任著者), Nonaka M, Nakabeppu Y
- Journal Title
  
  Nucleic Acids Res. 12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells.2010
- Author(s)
  Sakumi, K., N.Abolhassani, M.Behmanesh, T.Iyama, D.Tsuchimoto, Y.Nakabeppu.
- Journal Title
  
  Mutat Res
  
  Volume: 703 Pages: 43-50
- NAID
  120005227205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] NUDT16 is a (deoxy) inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2010
- Author(s)
  Iyama, T., N.Abolhassani, D.Tsuchimoto, M.Nonaka, Y.Nakabeppu.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 4834-4843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dIDP/IDP from nucleotide pools in mammals.2010
- Author(s)
  Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y.
- Journal Title
  
  Nucleic Acids Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1.2010
- Author(s)
  Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E, Lord CJ, Ashworth A
- Journal Title
  
  Cancer Cell 17
  
  Pages: 235-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
- Author(s)
  Abolhassani, N., T.Iyama, D.Tsuchimoto, K.Sakumi, M.Ohno, M.Behmanesh, Y.Nakabeppu.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 2891-2903
- NAID
  120005227421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
- Author(s)
  Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 2891-2903
- NAID
  120005227421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241013
[Journal Article] Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis.2009
- Author(s)
  Gushima M, Hirahashi M, Matsumoto T, Fujita K, Fujisawa R, Mizumoto K, Nakabeppu Y, Iida M, Yao T, Tsuneyoshi M
- Journal Title
  
  J Pathol 219
  
  Pages: 77-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase2009
- Author(s)
  Nonaka M, Tsuchimoto D(責任著者), Sakumi K, Nakabeppu Y
- Journal Title
  
  preferring 5-iodocytosine. FEBS J. 276(6)
  
  Pages: 1654-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Altered expression of MUTYH and an increase in 8-hydroxy-deoxyguanosine are early events in ulcerative colitis-associated carcinogenesis.2009
- Author(s)
  Gushima M, Hirahashi M, Matsumoto T, Fujita K, Fujisawa R, Mizumoto K, Nakabeppu Y, Iida M, Yao T, Tsuneyoshi M
- Journal Title
  
  Journal of Pathology 219
  
  Pages: 77-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] 塩基除去修復酵素MUTYHに依存したプログラム細胞死と発癌抑制機構2009
- Author(s)
  中別府雄作
- Journal Title
  
  実験医学 27巻
  
  Pages: 135-139
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] ITPase-deficient mice show growth retardation and die before weaning.2009
- Author(s)
  Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y.
- Journal Title
  
  Cell Death and Differentiation 16
  
  Pages: 1315-1322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] ミトコンドリアのデオキシリボヌクレオチドプールの酸化と細胞死2009
- Author(s)
  中別府雄作
- Journal Title
  
  医学のあゆみ 232巻
  
  Pages: 681-689
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.2009
- Author(s)
  Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.
- Journal Title
  
  International Immunology 21
  
  Pages: 947-955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage2009
- Author(s)
  Oka S, Ohno M, Nakabeppu Y.
- Journal Title
  
  Methods in Molecular Biology 554
  
  Pages: 251-264
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method.2009
- Author(s)
  Ohno M, Oka S, Nakabeppu Y.
- Journal Title
  
  Methods in Molecular Biology 554
  
  Pages: 199-212
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methy1-4-pheny1-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.2009
- Author(s)
  Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M.
- Journal Title
  
  PLoS One 30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.2009
- Author(s)
  Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.
- Journal Title
  
  Int Immunol. 8
  
  Pages: 947-55
- NAID
  10025387710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] ITPase-deficient mice show growth retardation and die before weaning2009
- Author(s)
  Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y(責任著者)
- Journal Title
  
  Cell Death Differ. 10
  
  Pages: 1315-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] AIF2009
- Author(s)
  中別府雄作
- Journal Title
  
  Medical Tribune 42巻
  
  Pages: 46-46
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.2008
- Author(s)
  Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y
- Journal Title
  
  DNA Repair 7
  
  Pages: 418-430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines.2008
- Author(s)
  Yamamoto S, Tanaka K, Sakimura R, Okada T, Nakamura T, Li Y, Takasaki M, Nakabeppu Y, Iwamoto Y
- Journal Title
  
  Anticancer Res 28
  
  Pages: 1585-1591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.2008
- Author(s)
  Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y
- Journal Title
  
  EMBO J 27
  
  Pages: 421-432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus.2008
- Author(s)
  Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, Kanda T, Sakumi K, Nakabeppu Y
- Journal Title
  
  DNA Repair 7
  
  Pages: 1437-1454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.2008
- Author(s)
  De Luca G, Russo MT, Degan P, Tiveron C, Zijno A, Meccia E, Ventura I, Mattei E, Nakabeppu Y, Crescenzi M, Pepponi R, Pezzola A, Popoli P, Bignami M.
- Journal Title
  
  PLoS Genet. 4(11)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] 核およびミトコンドリアDNAの酸化損傷によって引き起こされる2つの独立した細胞死の経路2008
- Author(s)
  岡素雅子, 中別府雄作
- Journal Title
  
  実験医学 26巻
  
  Pages: 1376-1379
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus.2008
- Author(s)
  Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, Kanda T, Sakumi K, Nakabeppu Y(責任著者)
- Journal Title
  
  DNA Repair (Amst). 7(9)
  
  Pages: 1437-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.2008
- Author(s)
  Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y(責任著者).
- Journal Title
  
  EMBO J. 27(2)
  
  Pages: 421-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.2008
- Author(s)
  Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y(責任著者)
- Journal Title
  
  DNA Repair (Amst). 7(3)
  
  Pages: 418-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis.2008
- Author(s)
  Yanaru-Fujisawa R, Matsumoto T, Ushijima, Y, Esaki M, Hirahashi M, Gushima M, Yao T, Nakabeppu Y, Iida M
- Journal Title
  
  Clin Genet 73
  
  Pages: 545-553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] A Role for Oxidized DNA Precursors in Huntington's Disease-Like Striatal Neurodegeneration.2008
- Author(s)
  De Luca G, Russo MT, Degan P, Tiveron C, Zijno A, Meccia E, Ventura I, Mattei E, Nakabeppu Y, Crescenzi M, Pepponi R, Pezzola A, Popoli P, Bignami M
- Journal Title
  
  PLoS Genet 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.2008
- Author(s)
  Nakane H, Hirota S, Brooks PJ, Nakabeppu Y, Nakatsu, Y, Nishimune Y, Iino A, Tanaka K
- Journal Title
  
  DNA Repair 7
  
  Pages: 1938-1950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013034
[Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease2007
- Author(s)
  Nakabeppu, Y, et. al.
- Journal Title
  
  J Neurosci Res 85(5)
  
  Pages: 919-934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis.2007
- Author(s)
  Sakamoto K, Tominaga Y, Yamauchi K, Nakatsu Y, Sakumi K, Yoshiyama K, Egashira A, Kura S, Yao T, Tsuneyoshi M, Maki H, Nakabeppu Y(共同責任著者), Tsuzuki T.
- Journal Title
  
  Cancer Res. 67(14)
  
  Pages: 6599-604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.2007
- Author(s)
  Miyata, K., Yasukawa, T., Fukuda, M., Takeuchi, T., Yamazaki, K., Sakumi, K., Tamamori-Adachi, M., Ohnishi, Y., Ohtsuki, Y., Nakabeppu, Y., Kitajima, S., Onishi, S., Aso, T.
- Journal Title
  
  Cell Death Differ. 14・4
  
  Pages: 716-726
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Accumulation of 8-oxo-deoxyguanosine in Cardiovascular Tissues with the Development of Hypertension.2007
- Author(s)
  Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M., Nakabeppu, Y.
- Journal Title
  
  DNA Repair (印刷中)
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis.2007
- Author(s)
  Tsuzuki, T., Nakatsu, Y., Nakabeppu, Y.
- Journal Title
  
  Cancer Sci (印刷中)
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer.2007
- Author(s)
  Kunisada M, Kumimoto H, Ishizaki K, Sakumi K, Nakabeppu Y, Nishigori C.
- Journal Title
  
  J Invest Dermatol. 127(12)
  
  Pages: 2865-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination.2007
- Author(s)
  Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, Stavnezer J, Schrader CE.
- Journal Title
  
  J Exp Med. 204(12)
  
  Pages: 3017-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Oxidative damage in nucleic acids and Parkinson's disease.2007
- Author(s)
  Nakabeppu Y., et. al.
- Journal Title
  
  J Neurosci Res. 85(5)
  
  Pages: 919-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Oxidative damage in nucleic acids and Parkinson's disease2007
- Author(s)
  Nakabeppu Y., et. al.
- Journal Title
  
  J.Neurosci.Res 85
  
  Pages: 919-934
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Oxidative damage in nucleic acids and Parkinson's disease.2007
- Author(s)
  Nakabeppu Y., et. al.
- Journal Title
  
  J Neurosci Res. 85(5)
  
  Pages: 919-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Accumulation of 8-oxo-deoxyguanosine in Cardiovascular Tissues with the Development of Hypertension.2007
- Author(s)
  Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M., Nakabeppu,Y.
- Journal Title
  
  DNA Repair (印刷中)
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Oxidative damage in nucleic acids and Pakinson's disease.2007
- Author(s)
  Nakabeppu, Y, et. al.
- Journal Title
  
  J Neurosci Res. 85(5)
  
  Pages: 919-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] RNA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.2007
- Author(s)
  Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Seah, J., Kwei, M., Ikegami, T., Handa, H., Nakabeppu, Y., Tanaka,K
- Journal Title
  
  DNA Repair (印刷中)
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.2007
- Author(s)
  Miyata, K., Yasukawa, T., Fukuda, M., Takeuchi, T., Yamazaki, K., Sakumi, K., Tamamori-Adachi, M., Ohnishi, Y., Ohtsuki, Y., Nakabeppu, Y., Kitajima, S., Onishi, S., Aso, T.
- Journal Title
  
  Cell Death Differ. 14・4
  
  Pages: 716-726
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, in Oxidative Damage to Nucleic Acids.2007
- Author(s)
  Nakabeppu, Y. et al.
- Journal Title
  
  Georgetown, TX. : Landes Bioscience/Eurekah (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis.2007
- Author(s)
  Tsuzuki, T., Nakatsu, Y., Nakabeppu, Y.
- Journal Title
  
  Cancer Sci (印刷中)
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Oxidative Damage in Nucleit Acids and Parkinson's Disease.2007
- Author(s)
  Nakabeppu, Y., Tsuchimoto, D., Yamaguchi, H., Sakumi, K.
- Journal Title
  
  J. Neurosci, Res. 85・5
  
  Pages: 919-934
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis.2007
- Author(s)
  Tsuzuki, T., Nakatsu, Y., Nakabeppu, Y.
- Journal Title
  
  Cancer Sci. (印刷中)
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease.2007
- Author(s)
  Nakabeppu, Y., Tsuchimoto, D., Yamaguchi, H., Sakumi, K.
- Journal Title
  
  J.Neurosci.Res. 85・5
  
  Pages: 919-934
- NAID
  120000985083
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] RNA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor FTIIS.2007
- Author(s)
  Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Seah, J., Kwei, M., Ikegami, T., Handa, H., Nakabeppu, Y., Tanaka, K
- Journal Title
  
  DNA Repair (印刷中)
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease.2007
- Author(s)
  Nakabeppu, Y. et al.
- Journal Title
  
  J. Neurosci. Res. 85(5)
  
  Pages: 919-934
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease.2007
- Author(s)
  Nakabeppu, Y. et al.
- Journal Title
  
  J.Neurosci.Res. 85(5)
  
  Pages: 919-934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Accumulation of 8-oxo-deoxyguanosine in Cardiovascular Tissues with the Development of Hypertension.2007
- Author(s)
  Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M., Nakabeppu, Y.
- Journal Title
  
  DNA Repair (印刷中)
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] RNA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.2007
- Author(s)
  Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Seah, J., Kwei, M., Ikegami, T., Handa, H., Nakabeppu, Y., Tanaka, K
- Journal Title
  
  DNA Repair (印刷中)
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
- Author(s)
  Nakabeppu, Y., et. al.
- Journal Title
  
  Biol Chem 387(4)
  
  Pages: 373-379
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] 酸化ストレスとミトコンドリア2006
- Author(s)
  中別府雄作, 他
- Journal Title
  
  Clinical Neuroscience 21
  
  Pages: 79-83
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Mutagenesis and Carcinogenesis Caused by the Oxidation of Nucleic Acids.2006
- Author(s)
  Y.Nakabeppu, et al.
- Journal Title
  
  Biological Chemistry 387(in press)
- Data Source
  KAKENHI-PROJECT-17014070
[Journal Article] MTH1, an oxidized purine nucleoside triphospghatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydrophridine.2006
- Author(s)
  Yamaguchi, H., Kajitani, K., Dan, Y., Furuichi, M., Ohno, M., Sakumi, K., Kang, D., Nakabeppu.Y.
- Journal Title
  
  Cell Death Differ. 13・4
  
  Pages: 551-563
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
- Author(s)
  Nakabeppu, Y. et al.
- Journal Title
  
  Biol.Chem. 387(4)
  
  Pages: 373-379
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease.2006
- Author(s)
  Arai, T., Fukae, J., Hatano, T., Kubo, S., Ohtsubo, T., Nakabeppu, Y., Mori, H., Mizuno, Y., Hattori, N.
- Journal Title
  
  Acta Neuropathol. 112・2
  
  Pages: 139-145
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Angiotensin I-converting enzyme gene polyorphism modifies the smoking-cancer association : the Hisayama Study.2006
- Author(s)
  Arima, H., Kiyohara, Y., Tanizaki, Y., Nakabeppu, Y., Kubo, M., Kato, I., Sueishi, K., Tsuneyoshi, M., Fujishima, M., Iida, M.
- Journal Title
  
  Eur. J. Cancer Prev. 15・3
  
  Pages: 196-201
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Recognition of Nucleotide Analogs containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein.2006
- Author(s)
  Kamiya, H., Cadena-Amaro, C., Dugue, L., Yakushiji, H., Minakawa, N., Matsuda, A., Pochet, S., Nakabeppu, Y., Harashima, H.
- Journal Title
  
  J. Biochem. 140・6
  
  Pages: 843-849
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
- Author(s)
  Nakabeppu, Y. et al.
- Journal Title
  
  Biol. Chem. 387(4)
  
  Pages: 373-379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.2006
- Author(s)
  Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., Nakabeppu, Y.
- Journal Title
  
  Genome Res. 16・5
  
  Pages: 567-575
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
- Author(s)
  Nakabeppu, Y., Sakumi, K., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T., Nakatsu, Y.
- Journal Title
  
  Biol. Chem. 387・4
  
  Pages: 373-379
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Reactive oxigen species and regulation of biological function2006
- Author(s)
  Nakabeppu, Y
- Journal Title
  
  BIO Clinina 21(12)
  
  Pages: 79-83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
- Author(s)
  Nakabeppu, Y., et. al.
- Journal Title
  
  DNA Repair 5(7)
  
  Pages: 761-772
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.2006
- Author(s)
  Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H., Poirier, F., Griffioen, A.W.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A. 103・43
  
  Pages: 15975-15980
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
- Author(s)
  Nakabeppu, Y., Kajitani, K., Sakamoto, K., Yamaguchi, H., Tsuchimoto, D.
- Journal Title
  
  DNA Repair 5・7
  
  Pages: 761-772
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides.2006
- Author(s)
  Y.Nakabeppu et al.
- Journal Title
  
  Oxidative Damage to Nucleic Acids (On line)
- Data Source
  KAKENHI-PROJECT-17014070
[Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
- Author(s)
  Nakabeppu, Y., Kajitani, K., Sakamoto, K., Yamaguchi, H., Tsuchimoto, D.
- Journal Title
  
  DNA Repair 5・7
  
  Pages: 761-772
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.2006
- Author(s)
  Yamaguchi, H., Kajitani, K., Dan, Y., Furuichi, M., Ohno, M., Sakumi, K., Kang, D., Nakabeppu, Y.
- Journal Title
  
  Cell Death Differ. 13・4
  
  Pages: 551-563
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.2006
- Author(s)
  Sakai, Y., Oda, H., Yoshimura, D., Furuichi, M., Kang, D., Iwai, S., Hara, T., Nakabeppu, Y.
- Journal Title
  
  J. Mol. Med. 84・8
  
  Pages: 660-670
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
- Author(s)
  Nakabeppu, Y. et al.
- Journal Title
  
  DNA Repair 5(7)
  
  Pages: 761-772
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Neonatal Ventral Hippocampal Lesions Produce an Elevation of ΔFosB-like Protein(s) In the Rodent Neocortex.2006
- Author(s)
  Powell, K.J., Binder, T.L., Hori, S., Nakabeppu, Y., R., D., Weinberger, Lipska, B.K., Robertson, G.S.
- Journal Title
  
  Neuropsychopharmacology 31・4
  
  Pages: 700-711
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.2006
- Author(s)
  Akatsuka, S., Aung, T.T., Dutta, K.K., Jiang, L., Lee, W.H., Liu, Y.T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., Naito, Y., Yoshikawa, T., Kasai, H., Tominaga, Y., Sakumi, K., Nakabeppu, Y., Kawai, Y., Uchida, K., Yamasaki, A., Tsuruyama, T., Yamada, Y., Toyokuni, S.
- Journal Title
  
  Am. J. Pathol. 169・4
  
  Pages: 1328-1342
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein.2006
- Author(s)
  Kamiya, H., Cadena-Amaro, C., Dugue, L., Yakushiji, H., Minakawa, N., Matsuda, A., Pochet, S., Nakabeppu, Y., Harashima,H.
- Journal Title
  
  J.Biochem. 140・6
  
  Pages: 843-849
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Neurodgenerative diseases and oxidative stress2006
- Author(s)
  Nakabeppu., Y., et. al.
- Journal Title
  
  Bunnshi Saibou Chiryou 5(6)
  
  Pages: 35-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.2006
- Author(s)
  Akatsuka, S., Aung, T.T., Dutta, K.K., Jiang, L, Lee, W.H., Liu, Y.T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., Naito, Y., Yoshikawa, T., Kasai, H., Tominaga, Y., Sakumi, K., Nakabeppu, Y., Kawai, Y., Uchida, K., Yamasaki, A., Tsuruyama, T., Yamada,Y., Toyokuni,S.
- Journal Title
  
  Am.J.Pathol. 169・4
  
  Pages: 1328-1342
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease.2006
- Author(s)
  Arai, T., Fukae, J., Hatano, T., Kubo, S., Ohtsubo, T., Nakabeppu, Y., Mori, H., Mizuno, Y., Hattori, N.
- Journal Title
  
  Acta Neuropathol. 112・2
  
  Pages: 139-145
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.2006
- Author(s)
  Nakamura, T., Kitaguchi, Y., Miyazawa, M., Kamiya, H., Toma, S., Ikemizu, S., Shirakawa, M., Nakabeppu, Y, Yamagata, Y.
- Journal Title
  
  Acta Crystallograph.Sect.F.Struct.Biol.Cryst.Commun. 62・12
  
  Pages: 1283-1285
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein.2006
- Author(s)
  Kamiya, H., Cadena-Amaro, C., Dugue, L., Yakushiji, H., Minakawa, N., Matsuda, A., Pochet, S., Nakabeppu, Y., Harashima, H.
- Journal Title
  
  J. Biochem. 140・6
  
  Pages: 843-849
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides2006
- Author(s)
  Y.Nakabeppu et al.
- Journal Title
  
  DNA Repair (in press)
- Data Source
  KAKENHI-PROJECT-17014070
[Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.2006
- Author(s)
  Akatsuka, S., Aung, T.T., Dutta, K.K., Jinag.L., Lee, W.H., Liu, Y.T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., Naito, Y., Yoshikawa, T., Kasai, H., Tominaga, Y., Sakumi, K., Nakabeppu, Y., Kawai, Y., Uchida, K., Yamasaki, A., Tsuruyama, T., Yamada, Y., Toyokuni, S.
- Journal Title
  
  Am. J. Pathol. 169・4
  
  Pages: 1328-1342
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an altemative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.2006
- Author(s)
  Sakai, Y., Oda, H., Yoshimura, D., Furuichi, M., Kang, D., Iwai, S., Hara, T., Nakabeppu,Y.
- Journal Title
  
  J.Mol.Med. 84・8
  
  Pages: 660-670
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] 活性酸素と生命機能の制御2006
- Author(s)
  中別府雄作, 他
- Journal Title
  
  BIO Clinica 5
  
  Pages: 35-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.2006
- Author(s)
  Yamaguchi, H., Kajitani, K., Dan, Y., Furuichi, M., Ohno, M., Sakumi, K., Kang, D., Nakabeppu,Y.
- Journal Title
  
  Cell Death Differ. 13・4
  
  Pages: 551-563
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.2006
- Author(s)
  Nakamura, T., Kitaguchi, Y., Miyazawa, M., Kamiya, H., Toma, S., Ikemizu, S., Shirakawa, M., Nakabeppu, Y., Yamagata, Y.
- Journal Title
  
  Acta Crystallograph, Sect. F. Struct. Biol. Cryst. Commun. 62・12
  
  Pages: 1283-1285
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.2006
- Author(s)
  Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., Nakabeppu,Y.
- Journal Title
  
  Genome Res. 16・5
  
  Pages: 567-575
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice.2006
- Author(s)
  Arima, T., Yamasaki, K., John.R.M., Kato, K., Sakumi, K., Nakabeppu, Y., Wake, N., Kono, T.
- Journal Title
  
  Genomics 88・5
  
  Pages: 650-658
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease.2006
- Author(s)
  Arai, T., Fukae, J., Hatano, T., Kubo, S., Ohtsubo, T., Nakabeppu, Y., Mori, H., Mizuno, Y, Hattori,N.
- Journal Title
  
  Acta Neuropathol. 112・2
  
  Pages: 139-145
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Oxidative stress and mirochondria2006
- Author(s)
  Nakabeppu, Y
- Journal Title
  
  Clinical Neuroscience 24(6)
  
  Pages: 639-642
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice.2006
- Author(s)
  Arima, T., Yamasaki, K., John, R.M., Kato, K., Sakumi, K., Nakabeppu, Y., Wake, N., Kono, T.
- Journal Title
  
  Genomics 88・5
  
  Pages: 650-658
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
- Author(s)
  Nakabeppu, Y., Sakumi, K., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T., Nakatsu,Y.
- Journal Title
  
  Biol.Chem. 387・4
  
  Pages: 373-379
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids2006
- Author(s)
  Nakabeppu Y., et. al.
- Journal Title
  
  Biol Chem 387
  
  Pages: 373-379
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] MTH1,an oxidized purine nucleoside triphosphatase,prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides2006
- Author(s)
  Nakabeppu Y., et. al.
- Journal Title
  
  DNA Repair 5
  
  Pages: 761-772
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] 活性酸素によるゲノムの酸化とヒトゲノムの多様性2006
- Author(s)
  中別府雄作, 他
- Journal Title
  
  実験医学 24
  
  Pages: 756-1753
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.2006
- Author(s)
  Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., Nakabeppu, Y.
- Journal Title
  
  Genome Res. 16・5
  
  Pages: 567-575
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Oxidation of genome by reactive oxygen species and diversity of human genome2006
- Author(s)
  Nakabeppu, Y., et. al.
- Journal Title
  
  Jikken Igaku 24(1)
  
  Pages: 756-1753
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] MTH1,an oxidized purine nucleoside triphosphatase,prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
- Author(s)
  Nakabeppu, Y., Kajitani, K., Sakamoto, K., Yamaguchi, H., Tsuchimoto,D.
- Journal Title
  
  DNA Repair 5・7
  
  Pages: 761-772
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] Neonatal Ventral Hippocampal Lesions Produce an Elevation of ΔFosB-like Protein(s) In the Rodent Neocortex.2006
- Author(s)
  Powell, K.J., Binder, T.L., Hori, S., Nakabeppu, Y., R., D., Weinberger, Lipska, B.K., Robertson, G.S.
- Journal Title
  
  Neuropsychopharmacology 31・4
  
  Pages: 700-711
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] 脳神経変性疾患と酸化ストレス2006
- Author(s)
  中別府雄作, 他
- Journal Title
  
  分子細胞治療 5
  
  Pages: 35-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.2006
- Author(s)
  Thijssen, V.L., Postel, r。, Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum.L G., Bakkers, J., Mayo, K H., Poirier, F., Brifficen, A.W.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A. 103・43
  
  Pages: 15975-15980
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an altemative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.2006
- Author(s)
  Sakai, Y., Oda, H., Yoshimura, D., Furuichi, M., Kang, D., Iwai, S., Hara, T., Nakabeppu, Y.
- Journal Title
  
  J. Mol. Med. 84・8
  
  Pages: 660-670
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association : the Hisayama Study.2006
- Author(s)
  Arima, H., Kiyohara, Y., Tanizaki, Y., Nakabeppu, Y., Kubo, M., Kato, I., Sueishi, K., Tsuneyoshi, M., Fujishima, M., Iida, M.
- Journal Title
  
  Eur. J. Cancer Prev. 15・3
  
  Pages: 196-201
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.2006
- Author(s)
  Nakamura, T., Kitaguchi, Y., Miyazawa, M., Kamiya, H., Toma, S., Ikemizu, S., Shirakawa, M., Nakabeppu, Y., Yamagata, Y.
- Journal Title
  
  Acta Crystallograph. Sect. F. Struct. Biol. Cryst. Commun. 62・12
  
  Pages: 1283-1285
- Data Source
  KAKENHI-PROJECT-18013038
[Journal Article] Mutagenesis and carcinogenesis carsed by the oxidation of nucleic acids.2006
- Author(s)
  Nakabeppu, Y., Sakumi, K., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T., Nakatsu, Y.
- Journal Title
  
  Biol. Chem. 387・4
  
  Pages: 373-379
- Data Source
  KAKENHI-PROJECT-18300124
[Journal Article] A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA.2005
- Author(s)
  Ushijima Y, Tominaga Y, Miura T, Tsuchimoto D, Sakumi K, Nakabeppu Y.
- Journal Title
  
  Nucleic Acids Research 33・2
  
  Pages: 672-682
- Data Source
  KAKENHI-PROJECT-16012248
[Journal Article] A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA2005
- Author(s)
  Ushijima Y, Tominaga Y, Miura T, Tsuchimoto D, Sakumi K, Nakabeppu Y
- Journal Title
  
  Nucleic Acids Res. 33
  
  Pages: 672-682
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510041
[Journal Article] Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs2004
- Author(s)
  Kamiya H, Yakushiji H, Dugue L, Tanimoto M, Pochet S, Nakabeppu Y, Harashima H
- Journal Title
  
  J Mol Biol. 336
  
  Pages: 843-850
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510041
[Journal Article] A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae2004
- Author(s)
  Nunoshiba T, Ishida R, Sasaki M, Iwai S, Nakabeppu Y, Yamamoto K
- Journal Title
  
  Nucleic Acids Res. 32
  
  Pages: 5339-5348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510041
[Journal Article] Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice.2004
- Author(s)
  Ide Y, Tsuchimoto D, Tominaga Y, Nakashima M, Watanabe T, Sakumi K, Ohno M, Nakabeppu Y.
- Journal Title
  
  Blood 104・13
  
  Pages: 4097-4103
- Data Source
  KAKENHI-PROJECT-16012248
[Journal Article] A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c(PCD1 gene) in Saccharomyces cerevisiae.2004
- Author(s)
  Nunoshiba T, Ishida R, Sasaki M, Iwai S, Nakabeppu Y, Yamamoto K.
- Journal Title
  
  Nucleic Acids Research 32・18
  
  Pages: 5339-5348
- Data Source
  KAKENHI-PROJECT-16012248
[Journal Article] The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death2004
- Author(s)
  Nakabeppu Y, Tsuchimoto D, Furuichi M, Sakumi K
- Journal Title
  
  Free Radical Res. 38
  
  Pages: 423-429
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510041
[Journal Article] The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death2004
- Author(s)
  Nakabeppu Y
- Journal Title
  
  Free Radical Res 38
  
  Pages: 423-429
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510041
[Journal Article] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates.2004
- Author(s)
  Mishima M, Sakai Y, Itoh N, Kamiya H, Furuichi M, Takahashi M, Yamagata Y, Iwai S, Nakabeppu Y, Shirakawa M.
- Journal Title
  
  Journal of Biological Chemistry 279・32
  
  Pages: 33806-33815
- Data Source
  KAKENHI-PROJECT-16012248
[Journal Article] The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death.2004
- Author(s)
  Nakabeppu Y, Tsuchimoto D, Furuichi M, Sakumi K.
- Journal Title
  
  Free Radical Research 38・5
  
  Pages: 423-429
- Data Source
  KAKENHI-PROJECT-16012248
[Journal Article] A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients2004
- Author(s)
  Kimura Y, Oda S, Egashira A, Kakeji Y, Baba H, Nakabeppu Y, Maehara Y.
- Journal Title
  
  Journal of Medical Genetics 41・5
- Data Source
  KAKENHI-PROJECT-16012248
[Journal Article] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates2004
- Author(s)
  Mishima M, Sakai Y, Itoh N, Kamiya H, Furuichi M, Takahashi M, Yamagata Y, Iwai S, Nakabeppu Y, Shirakawa M
- Journal Title
  
  J Biol Chem. 279
  
  Pages: 33806-33815
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510041
[Journal Article] Futile short-patch DNA base excision repair of adenine : 8-oxoguanine mispair.2004
- Author(s)
  Hashimoto K, Tominaga Y, Nakabeppu Y, Moriya M.
- Journal Title
  
  Nucleic Acids Research 32・19
  
  Pages: 5928-5934
- Data Source
  KAKENHI-PROJECT-16012248
[Journal Article] Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption2003
- Author(s)
  Sakumi K, Tominaga Y, Furuichi M, Xu P, Tsuzuki T, Sekiguchi M, Nakabeppu Y.
- Journal Title
  
  Cancer Res. 63
  
  Pages: 902-905
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510041
[Journal Article] An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress2003
- Author(s)
  Yoshimura D, Sakumi K, Ohno M, Sakai Y, Furuichi M, Iwai S, Nakabeppu Y
- Journal Title
  
  J Biol Chem. 278
  
  Pages: 37965-37973
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510041
[Journal Article] DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1
- Author(s)
  Sarah A. Martin, Nuala McCabe, Michelle Mullarkey, Robert Cummins, Darren J. Burgess, Y Nakabeppu, S Oka, Elaine Kay, Christopher J. Lord and Alan Ashworth
- Journal Title
  
  Cancer Cell
  
  Volume: 17 Pages: 235-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] Shank3aは生後早期マウスのけいれん感受性を制御する2023
- Author(s)
  奥園清香、藤井史彦、松下悠紀、瀬戸山大樹、新明洋平、平良遼志、米元耕輔、赤峰哲、本村良知、實藤雅文、櫻井武、河﨑洋志、Kihoon Han、加藤隆弘、鳥巣浩幸、康東天、中別府雄作、酒井康成、大賀正一
- Organizer
  第126回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07865
[Presentation] Shank3aは生後早期マウスのけいれん感受性を制御する2023
- Author(s)
  奥園清香、藤井史彦、松下悠紀、瀬戸山大樹、新明洋平、平良遼志、米元耕輔、赤峰哲、本村良知、實藤雅文、櫻井武、河﨑洋志、 Kihoon Han、加藤隆弘、鳥巣浩幸、康東天、中別府雄作、酒井康成、大賀正一
- Organizer
  第126回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07865
[Presentation] Shank3a regulates the susceptibility to seizure and thalamocortical connectivity2021
- Author(s)
  Sayaka Okuzono, Yuki Matsushita, Yasunari Sakai*, Ryoji Taira, Kousuke Yonemoto, Satoshi Akamine, Yoshitomo Motomura, Masafumi Sanefuji, Yusaku Nakabeppu, Shouichi Ohga
- Organizer
  American Epilepsy Society Annual Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07865
[Presentation] 塩基修復酵素，OGG1とMUTYHの欠損はAppNL-G-Fノックイン・アルツハイマー病モデルマウスにおけるミクログリアの活性化状態と脳内のアミロイドβの沈着および行動様式を変化させる2019
- Author(s)
  水野裕理，Abolhassani Nona，Mazzei Guianfranco，斉藤貴志，西道隆臣，中別府雄作
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] High-fat diet exacerbates neuropathology in AppNL-F/NL-F mouse model of Alzheimer’s disease2019
- Author(s)
  Guianfranco Mazzei, Nona Abolhassani, Ryohei Ikegami, Naoki Haruyama, Takashi Saito, Takaomi C. Saido, Yusaku Nakabeppu
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Disturbed glutamate signaling in AD hippocampus revealed by an integrated analysis of altered expression profiles of genes in both human and mouse brains with Alzheimer's disease pathology2019
- Author(s)
  Nona Abolhassani, Masaaki Hokama, Daisuke Saitou, Masahiro Shijo, Takashi Saito, Takaomi C. Saido, Mikita Suyama, Toru Iwaki, Yutaka Kiyohara, Yusaku Nakabeppu
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Defense mechanisms against the dysfunction resulting from damage to the genome by reactive oxygen species during aging2019
- Author(s)
  Naoki Haruyama, Nona Abolhassani, Guianfranco Mazzei, Julio Leon, Zijing Sheng, Sugako Oka, Mizuki Ohno, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  The 2019 International Association of Gerontology and Geriatrics (IAGG) Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] マウスにおける神経幹細胞特異的ITPA欠損は神経細胞の脱分極を引き起こし，てんかん性発作と早期死亡の原因となる2019
- Author(s)
  土本大介，古賀祐一郎，林良憲，アボルハッサニノナ，米嶋康臣，作見邦彦，中西博，豊國伸哉，中別府雄作
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Altered gene expression profiles in Alzheimer’s disease model mice caused by deficiency in three genes counteracting the buildup of 8-oxoguanine in DNA2019
- Author(s)
  Nona Abolhassani, Yuri Mizuno, Guianfranco Mazzei, Takashi Saito, Takaomi C. Saido, Yusaku Nakabeppu
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] 加齢雌マウス脳に蓄積する8-オキソグアニンは海馬歯状回と大カレハ島の神経新生を障害し性的二形性をきたす2019
- Author(s)
  春山直樹，作見邦彦，加藤木敦央，土本大介，中別府雄作
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in dentate gyrus and major island of Calleja, and thus causing sexually dimorphic phenotypes2019
- Author(s)
  Yusaku Nakabeppu, Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Gabriele De Luca, Margherita Bignami
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Alzheimer's disease brain exhibits feature of brain diabetes with impaired insulin signaling, mitochondrial dysfunction and oxidative stress2019
- Author(s)
  Yusaku Nakabeppu
- Organizer
  Korean Society for Biochemistry and Molecular Biology International Conference 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] 活性酸素によるゲノム損傷に起因する機能障害とその防御機構の解明2018
- Author(s)
  中別府雄作
- Organizer
  日本遺伝学会第90回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Oxidative DNA damage and Repair in Cancer and Aging2018
- Author(s)
  Yusaku Nakabeppu, Nona Abolhassani, Eiko Ohta, Zijing Sheng, Mizuki Ohno, Daisuke Tsuchimoto, Kunihiko Sakumi
- Organizer
  The 14th Japan - Korea Joint Symposium on Cancer and Ageing Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Long-term exposure to high-fat diet significantly exacerbated cognitive deficit in aged AppNL-F/NL-F knock-in mouse model of Alzheimer’s disease along with persistent impaired glucose tolerance2018
- Author(s)
  Nona Abolhassani, Ryohei Ikegami, Naoki Haruyama, Guianfranco Mazzei, Takashi Saito, Takaomi C Saido, Yusaku Nakabeppu
- Organizer
  The 41st Annual Meeting of The Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain2018
- Author(s)
  7.Yusaku Nakabeppu, Sugako Oka, Julio Leon, Nona Abolhassani, Tomomi Ide, Dongchon Kang
- Organizer
  The 30th International Conference of the Korean Society for Molecular and Cellular Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] 活性酸素による核酸の酸化と脳の老化2018
- Author(s)
  中別府雄作
- Organizer
  第16回レドックス・ライフイノベーションシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis.2018
- Author(s)
  Reiji Hommyo, Satoshi O Suzuki, Nona Abolhassani, Hideomi Hamasaki, Masahiro Shijo, Norihisa Maeda, Hiroyuki Honda, Yusaku Nakabeppu, Toru Iwaki
- Organizer
  The 19th International Congress of Neuropathology, Tokyo.
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] アルツハイマー病を脳の糖尿病として捉える2018
- Author(s)
  中別府雄作
- Organizer
  知の拠点セミナー
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Accumulation of 8-oxoguanine in nuclear genome of neural progenitors in aged mouse brain causes atrophy of major island of Calleja resulting in locomotor hyperactivity2018
- Author(s)
  Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  The 41st Annual Meeting of The Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Oxidative DNA damage and repair in Alzheimer’s disease brain2017
- Author(s)
  Yusaku Nakabeppu
- Organizer
  6th US-Japan DNA Repair Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] アルツハイマー病脳におけるインスリン産生・応答系の破綻とミトコンドリア機能障害2017
- Author(s)
  中別府雄作
- Organizer
  医療薬学フォーラム 2017／第25回クリニカルファーマシーシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Accumulation of 8-oxoguanine in the nuclei of newly-generated GABAergic neurons in the nucleus accumbens and islands of Calleja contributes to locomotor hyperactivity in aged mice2017
- Author(s)
  Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  The 27th Hot Spring Harbor International Symposium
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] アルツハイマー病脳におけるミトコンドリア機能障害と炎症応答に起因する酸化ストレスの分子病態2017
- Author(s)
  中別府雄作
- Organizer
  第59回日本老年医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] アルツハイマー病脳におけるインスリン枯渇とミトコンドリア機能不全に起因する酸化ストレスの分子病態2017
- Author(s)
  中別府雄作
- Organizer
  第13回レドックス・ライフイノベーションシンポジウム
- Place of Presentation
  奈良
- Year and Date
  2017-03-16
- Invited
- Data Source
  KAKENHI-PROJECT-15K15085
[Presentation] ラット脳発生およびヒト筋萎縮性側索硬化症におけるCRYMの発現変化2017
- Author(s)
  本名嶺治, 鈴木諭, 濱崎英臣, 本田裕之, 北川玲華, 司城　昌大, 前田教寿, Nona Abolhassani, 中別府雄作, 岩城徹
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] 側坐核・カレハ島の新生GABAニューロンへの8-オキソグアニンの蓄積は加齢マウスの多動の原因となる2017
- Author(s)
  春山直樹, 作見邦彦, 加藤木　敦央, 土本大介, 中別府　雄作
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Protection of mitochondrial DNA from oxidative damage effectively blocks the mitochondria-mediated vicious cycle of Alzheimer's disease2017
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Julio Leon, Nona Abolhassani, Tomomi Ide, Dongchon Kang
- Organizer
  Consortium of Biological Sciences 2017
- Invited
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Oxidative DNA damage and repair in carcinogenesis and neurodegeneration2017
- Author(s)
  Yusaku Nakabeppu
- Organizer
  International Symposium on Immune Diversity and Cancer Therapy Kobe 2017
- Place of Presentation
  Kobe, Japan
- Year and Date
  2017-01-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15085
[Presentation] Molecular Pathophysiology of Impaired Glucose Metabolism, Mitochondrial Dysfunction, and Oxidative DNA Damage in Alzheimer's Disease Brain2017
- Author(s)
  Yusaku Nakabeppu, Naoki Haruyama, Guianfranco Mazzei, Ryouhei Ikegami, Nona Abolhassani
- Organizer
  The 5th Annual World Congress of Geriatrics and Gerontology 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Impaired hippocampal neurogenesis in APP mouse model of Alzheimer disease2017
- Author(s)
  Guianfranco Mazzei, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  Third International meeting in Bioscience (Young Peruvian Scientist Network)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Nuclear accumulation of 8-oxoguanine in nucleus accumbens neurons contributes to age-related locomotor hyperactivity in Mth1/Ogg1-double knockout mice2017
- Author(s)
  Naoki Haruyama, Atsuhisa Katogi, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  九州大学教育改革シンポジウム2017
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] アルツハイマー病進展における核あるいはミトコンドリアDNA中に蓄積した8-oxoguanineの役割2016
- Author(s)
  岡　素雅子, 盛　子敬, フリオ　レオン, 土本大介, 作見　邦彦, 中別府　雄作
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] アルツハイマー病進展における核あるいはミトコンドリアDNA中に蓄積した8-oxoguanineの役割2016
- Author(s)
  岡素雅子, 盛子敬, フリオレオン, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K15085
[Presentation] Cranial irradiation causes hippocampal degeneration through accumulation of 8-oxoguanine in mitochondrial DNA in neurons2015
- Author(s)
  Sheng Zijing, Nakabeppu Yusaku.
- Organizer
  日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] MUTYH-dependent programmed cell death triggered by 8-oxoguanine and its implication in tumor suppression and neurodegeneration2015
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  15th International Congress of Radition Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2015-05-25
- Invited
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] 8-Oxoguanine accumulated in mitochondrial DNA disturbs neuritic regeneration of cultured adult mouse cortical neurons under conditions of oxidative stress2015
- Author(s)
  Julio Leon, Kunihiko Sakumi, Sugako Oka, Erika Castillo, Yusaku Nakabeppu
- Organizer
  45th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15085
[Presentation] Cortical neurons isolated from adult Mth1/Ogg1-double-knockout mouse exhibit impaired neurite regeneration under conditions of oxidative stress2015
- Author(s)
  Julio Jesusu Leon Incio, Kunihiko Sakumi, Sugako Oka, Erika Castillo, Yusaku Nakabeppu
- Organizer
  The 38th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K15085
[Presentation] 活性酸素によるDNA損傷が引起こすさまざまな生命現象：突然変異から神経変性まで2015
- Author(s)
  中別府雄作, 岡素雅子, 盛子敬, 大野みずき, 土本大介, 作見邦彦
- Organizer
  第17回日本進化学会年大会
- Place of Presentation
  東京
- Year and Date
  2015-08-20
- Invited
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) breaks the vicious circle of oxidative stress and amyloid β accumulation in triple-transgenic mouse model of Alzheimer’s disease2015
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  第38回日本分子生物学会年会, 第88回日本生化学会　合同大会　(神戸)
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] アルツハイマー病脳における糖尿病関連遺伝子の発現異常：久山町研究2014
- Author(s)
  中別府雄作
- Organizer
  第46回城南神経懇話会
- Place of Presentation
  東京
- Year and Date
  2014-06-12
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Oxidation of nucleic acids and control mechanisms of genetic diversity in mammals.2014
- Author(s)
  Yusaku Nakabeppu, Mizuki Ohno, Ryutaro Fukumura, Yuki Iwasaki, Yoshimichi Ikemura, Teruhisa Tsuzuki, Yoichi Gondo, Kunihiko Sakumi
- Organizer
  International Symposium on Germline Mutagenesis and Biodiversification
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 神経変性疾患と酸化ストレス2014
- Author(s)
  中別府雄作
- Organizer
  26th Japanese Science Seminar in Baltimore
- Place of Presentation
  Baltimore, MD, U. S. A.
- Year and Date
  2014-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-oxo-dGTP generated in nucleotide pools is a major cause of neurodegeneration under oxidative stress.2014
- Author(s)
  Sheng Zijing, Sugako Oka, Yasuhiro Ikeda, Margherita Bignami, Yusaku Nakabeppu
- Organizer
  International symposium "New Frontier of Molecular Neuropathology 2014"
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2014
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  EUROMIT2014 International Meeting on Mitochondrial Pathology
- Place of Presentation
  TAMPERE FINLAND
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] アルツハイマー病脳における遺伝子発現の変化と酸化ストレス2014
- Author(s)
  中別府雄作
- Organizer
  基盤研究(S)公開シンポジウム・環境親電子物質のレドックス制御
- Place of Presentation
  つくば
- Year and Date
  2014-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine causes spontaneous de novo germline mutations : a study from the mutator mouse line.2014
- Author(s)
  Mizuki Ohno, Kunihiko Sakumi, Ryutaro Fukumura, Yuki Iwasaki, Yoshimichi Ikemura, Teruhisa Tsuzuki, Yoichi Gondo, Yusaku Nakabeppu
- Organizer
  SMBE Satellite Meeting/NIG International Symposium: The Causes of Genome Evolution
- Place of Presentation
  三島
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Drinking “hydrogen water” induces ghrelin secretion and protects dopaminergic neurons in MPTP-induced Parkinson’s disease model mice.2014
- Author(s)
  Megumi Yamafuji, Akio Matsumoto, Tomoko Tachibana, Yusaku Nakabeppu, Mami Noda, Haruyuki Nakaya
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quantitative detection of oxidative DNA damage in brains of the triple transgenic Alzheimer’s disease mouse model2013
- Author(s)
  Yoriko Akimoto, Sugako Oka, Julio Leon, Yusaku Nakabeppu
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair2013
- Author(s)
  38. Zing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  Gordon research conference on Oxidative Stress & Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] アルツハイマー病脳における糖尿病関連遺伝子の発現異常：久山町研究2013
- Author(s)
  外間政朗，岡素雅子，Julio Leon，二宮利治，本田裕之，佐々木健介，岩城徹，小原知之，清原裕，中別府雄作
- Organizer
  第18回日本神経精神医学会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性酸素による核酸の酸化と哺乳動物における遺伝子多様性の制御機構2013
- Author(s)
  中別府雄作, 大野みずき, 作見邦彦
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb遺伝子産物は補体C5aレセプターの遺伝子発現を制御することにより，ミクログリアの活性化に寄与している．2013
- Author(s)
  能丸寛子，作見邦彦，加藤木敦央，大西克典，梶谷康介，土本大介，Eric J. Nestler，中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾と生体応答2013
- Author(s)
  中別府雄作
- Organizer
  長崎大学がんゲノム不安定性研究拠点(NRGIC) 平成24年度第59回大学院セミナー
- Place of Presentation
  長崎
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via caspase-independent cell death pathway2013
- Author(s)
  岡素雅子, 中別府雄作
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer's disease model mice2013
- Author(s)
  Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quality control in the nucleotide pools is essential for cellular homeostasis.2013
- Author(s)
  Yusaku Nakabeppu
- Organizer
  Invited seminar at Istituto Superiore di Sanitá
- Place of Presentation
  Roma, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice.2013
- Author(s)
  Sugako Oka, Julio Leon, Masaaki Hokama, Atsuhisa Katogi, Sakumi Kunihiko, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior2013
- Author(s)
  33. Noriko Yutsudo, Takashi Kamada, Kosuke Kajitani, Hiroko Nomaru, Atsuhisa Katogi, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kei-ichiro Takase, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice: the effect of low-level exposure2013
- Author(s)
  續輝久, 大野みずき, 中津可道, 中別府雄作
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 核酸損傷と生体防御2013
- Author(s)
  中別府雄作, 岡素雅子, 盛子敬, 土本大介, 作見邦彦
- Organizer
  第24回日本生体防御学会学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cross-talk between insulin and other growth factors signaling regulate their neuroprotective functions.2013
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto, Erika Castillo, Yusaku Nakabeppu
- Organizer
  11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Molecular hydrogen protects against ischemic injury in optic nerves2013
- Author(s)
  Megumi Yamafuji, Kyota Fujita, Margaret Hamner, Nozomi Akimoto, Mizuho A Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce Ransom, Mami Noda
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Dual effects of Galectin-1 in amyotrophic lateral screlosis.2013
- Author(s)
  Yuko Kobayakawa, Kunihiko Sakumi, Yusaku Nakabeppu.
- Organizer
  The 43rd annual meeting of the Society for neuroscience
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PUBLICLY-25110724
[Presentation] Striatal degeneration initiated by a mitochondrial toxin, 3-nitropropionic acid is dependent on MUTYH-initiated base excision repair of 8-oxoguanine-paired adenine.2013
- Author(s)
  Yusaku Nakabeppu, Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi
- Organizer
  11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] デオキシイノシン三リン酸の蓄積はミスマッチ修復機構に依存した細胞増殖抑制とゲノム不安定性を引き起こす.2013
- Author(s)
  米嶋康臣, 土本大介, 外間政朗, Abolhassani Nona, 猪山輝昭, 作見邦彦, 塩見尚子, 森雅彦, 塩見忠博, 中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Oxidative damage in brain genomes and neuroprotective mechanisms.2013
- Author(s)
  Yusaku Nakabeppu, Zijing Sheng, Sugako Oka
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer's disease model mice.2013
- Author(s)
  岡素雅子, Julio Leon, 外間政朗, 加藤木敦央, 作見邦彦, 井手友美, Kang Dongchon, 中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] SOD1G93AトランスジェニックALSモデルマウスにおけるgalectin-1の発現2013
- Author(s)
  中別府雄作
- Organizer
  包括的脳科学研究推進支援ネットワーク平成25 年度夏のワークショップ
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PUBLICLY-25110724
[Presentation] Comprehensive analysis of gene expression regulated by Fosb gene in brain-derived cells2013
- Author(s)
  Hiroko Nomaru, Kunihiko Sakumi, Noriko Yutsudo, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study.2013
- Author(s)
  中別府雄作, 外間政朗, 岡素雅子, Julio Leon, 二宮利治, 本田裕之, 佐々木健介, 岩城徹, 小原知之, Frank M. LaFerla, 清原裕
- Organizer
  包括的脳科学研究推進支援ネットワーク平成25年度夏のワークショップ
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-dependent neurodegeneration initiated by mitochondrial accumulation of 8-oxoguanine in neurons is efficiently suppressed by MTH1 and OGG12013
- Author(s)
  Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
- Organizer
  10th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM)
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb gene products regulate expression of C5ar1 and C5l2 genes and microglial activation.2013
- Author(s)
  Hiroko Nomaru, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  The 43rd annual meeting of the Society for neuroscience
- Place of Presentation
  San Diego. CA, USA.
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Neuroprotection and slow aging induced by oxidative stress-resistant signaling driven by medical gas2013
- Author(s)
  Mami Noda, Kyota Fujita, Margaret Hamner, Chieri Higashi, Megumi Yamafuji, Nozomi Akimoto, Mizuho A Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce Ransom
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of the defense enzymes MTH1, OGG1 and MUTYH against oxidative damage in nucleic acids in the mouse brain2013
- Author(s)
  Zijing Sheng, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2013
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi & Yusaku Nakabeppu
- Organizer
  Gordon Research Conference on Oxidative Stress & Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化DNA 損傷に起因するde novo germline mutationの解析 (II)2013
- Author(s)
  作見邦彦, 大野みずき, 福村龍太郎, 権藤洋一, 岩崎裕貴, 池村淑道, 續輝久, 中別府雄作
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Dual effects of Galectin-1 in amyotrophic lateral sclerosis2013
- Author(s)
  Yuko Kobayakawa, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾に起因する病態とその防御機構2013
- Author(s)
  中別府雄作
- Organizer
  老化促進モデルマウス(SAM)研究協議会第28回研究発表会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Dual effects of Galectin-1 in amyotrophic lateral screlosis.2013
- Author(s)
  Yuko Kobayakawa, Kunihiko Sakumi, yusaku Nakabeppu
- Organizer
  The 43rd annual meeting of the Society for neuroscience
- Place of Presentation
  San Diego. CA, USA.
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quantitative detection of oxidative DNA damage in brains of the triple transgenic Alzheimer's disease mouse model.2013
- Author(s)
  Yoriko Akimoto, Sugako Oka, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Control mechanism to maintain the low level of deoxyinosine in DNA.2013
- Author(s)
  Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  Keystone Symposium on Genomic Instability and DNA Repair (X6)
- Place of Presentation
  Banff, Alberta, Canada
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2013
- Author(s)
  Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cytotoxic effects of X-ray irradiation on proliferating and differentiated human neuroblastoma cell line SH-SY5Y, and their modulation by BDNF and inhibitors for CDK5 and calpains.2013
- Author(s)
  Erika Castillo, Julio Leon, 秋本頼子, 作見邦彦, 岡素雅子, 土本大介, 中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾に起因する病態とその防御機構2013
- Author(s)
  中別府雄作
- Organizer
  山口大学遺伝子実験施設セミナー
- Place of Presentation
  宇部
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化DNA損傷と消化管がん．2013
- Author(s)
  大野みずき, 中津可道, 中別府雄作, 續輝久
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Involvement of galectin-1 and galectin-3 in GDNF-induced neurite outgrowth from adult rat DRG neurons.2013
- Author(s)
  Kazunori Sango, Shizuka Takaku, Hiroko Yanagisawa, Kazuhiko Watabe, Kunihiko Sakumi, Yusaku Nakabeppu, Francoise Poirier, Hidenori Horie, Toshihiko Kadoya
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PUBLICLY-25110724
[Presentation] Dual effects of Galectin-1 in amyotrophic lateral sclerosis.2013
- Author(s)
  Yuko Kobayakawa, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PUBLICLY-25110724
[Presentation] 酸化DNA 損傷に起因するde novo germline mutationの解析2013
- Author(s)
  大野みずき, 作見邦彦, 福村龍太郎, 権藤洋一, 岩崎裕貴, 池村淑道, 續輝久, 中別府雄作
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia.2012
- Author(s)
  H. Nomaru, N. Yutsudo, M. Hokoma, Y. Nakabeppu
- Organizer
  The Munich Life Science Symposium for Young Scientist <interact> 2012(招待講演)
- Place of Presentation
  Munich, Germany
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] 変異SOD1トランスジェニックマウスを用いた，筋萎縮性側索硬化症におけるガレクチン1の病態への関与の検討.2012
- Author(s)
  小早川優子，作見邦彦，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mice lacking fosB display impaired adult hippocampal neurogenesis and spontaneous epilepsy2012
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  The 21st Hot spring Harbor Symposium jointly with 8th Global COE International Symposium, Young Investigators Presentation
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] Synergistic interaction between insulin and other growth factors modulates their neuroprotective functions.2012
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine causes complex neurodegeneration in a MUTYH-dependent manner, which can be efficiently suppressed by MTH1 and/or OGG1.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
- Organizer
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Place of Presentation
  Yumebutai, Awaji, Hyogo
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Identification and quantification of radiation-induced modified purine nucleosides。2012
- Author(s)
  Yoriko Akimoto and Yusaku Nakabeppu,
- Organizer
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Place of Presentation
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Influence of 8-Oxoguanine on Mitotic and Meiotic Chromosome.2012
- Author(s)
  Mizuki Ohno, Kunihiko Sakumi, Teruhisa Tsuzuki, Yusaku Nakabeppu
- Organizer
  The 10th International Symposium on Chromosomal Aberrations
- Place of Presentation
  Amalfi, Italy
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化損傷塩基の修復機構は生殖細胞ゲノム変異を抑制し同系交配によるマウスの表現型の安定性に寄与する.2012
- Author(s)
  大野みずき，作見邦彦，福村龍太郎，権藤洋一，續輝久，中別府雄作
- Organizer
  日本環境変異学会第41回大会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2012
- Author(s)
  Sugako Oka, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本がん疫学分子疫学学会
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] Quality control in the nucleotide pools is essential for cellular homeostasis2012
- Author(s)
  Yusaku Nakabeppu
- Organizer
  Invited seminar at National Institute of Environmental Health Science, NIH
- Place of Presentation
  RTP, NC, USA
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] fosB遺伝子産物によるアナフィラトキシンC5a 走化性受容体遺伝子C5arとGpr77の発現制御機構の解析.2012
- Author(s)
  能丸寛子，作見邦彦，土本大介，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] fosB 遺伝子産物によるアナフィラトキシン C5a 走化性受容体遺伝子C5ar と Gpr77 の発現制御機構の解析2012
- Author(s)
  能丸寛子, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡.
- Year and Date
  2012-09-25
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] 活性酸素による核酸の修飾とゲノム応答の遺伝学.2012
- Author(s)
  中別府雄作，土本大介，盛子敬，岡素雅子，作見邦彦
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] イノシン三リン酸によるゲノム不安定化機構と細胞内イノシン三リン酸生成経路の解明.2012
- Author(s)
  米嶋康臣，土本大介，作見邦彦，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Base excision repair by MUTYH initiates calpain/PARP-dependent neurodegeneration under oxidative stress.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Neurodegeneration caused by two distinct signaling pathways dependent on 8-oxoguanine and MUTYH-initiated base excision repair.2012
- Author(s)
  Yusaku Nakabeppu
- Organizer
  The 2012 International Symposium on “Signaling Functions of Reactive Oxygen Species”, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT Japan
- Place of Presentation
  Fukuoka
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-オキソグアニンの修復機構をノックアウトするマウスは，生殖細胞ゲノム中の突然変異頻度の上昇と遺伝性の変異形質を呈する.2012
- Author(s)
  大野みずき，作見邦彦，福村龍太郎，権藤洋一，續輝久，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine, a spontaneously oxidized guanine base, promotes somatic and meiotic recombination, thus contributing to carcinogenesis and genomic diversity2012
- Author(s)
  Yusaku Nakabeppu
- Organizer
  Invited seminar at Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute, NIH
- Place of Presentation
  Bethesda, MA. USA
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cytotoxic effects of X-ray irradiation on proliferative and differentiated human neuroblastoma cell line, SH-SY5Y, and modulation by neurotrophic factors and CDK5 inhibitor.2012
- Author(s)
  Erika Castillo, Julio Leon, Yoriko Akimoto, Yasuto Yoneshima, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cooperative neuroprotection by insulin and neurotrophic factors.2012
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Erika Castillo, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである.2012
- Author(s)
  岡素雅子，レオンフリオ，土本大介，作見邦彦，中別府雄作
- Organizer
  第35回日本がん疫学・分子疫学研究会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] fosB遺伝子産物によるアナフィラトキシンC5a走化性受容体遺伝子 C5arとGpr77の発現制御機構の解析2012
- Author(s)
  能丸寛子, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] GDNFはRET-PI3K経路を介してDRGニューロンの神経突起伸長ならびにGalectin-1の発現を誘導する.2012
- Author(s)
  高久静香, 柳澤比呂子, 渡部和彦, 中別府雄作, Francoise Poirier, 堀江秀典, 門屋利彦, 三五一憲
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2012
- Author(s)
  H.Nomaru, N.Yutsudo, M.Hokoma, Y.Nakabeppu
- Organizer
  The munich Life Science Symposium for Young Scientist <interact>2012
- Place of Presentation
  Munich, Germany(招待講演)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] fosB遺伝子産物によるアナフィラトキシンC5a走化性受容体遺伝子C5arとGpr77の発現制御機構の解析.2012
- Author(s)
  能丸寛子，作見邦彦，土本大介，中別府雄作
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ストレスは MUTYH による塩基除去修復経路を介してcalpain/PARP 依存性の神経変性を引き起こす.2012
- Author(s)
  盛子敬，岡素雅子，土本大介，作見邦彦，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2012
- Author(s)
  Hiroko Nomaru, Noriko Yutsudo, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-18
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
- Organizer
  The 9th ASMRM and Chinese Mit'2012
- Place of Presentation
  Beijing, China
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides and defense systems in mammalian cells.2012
- Author(s)
  Daisuke Tsuchimoto, Teruaki Iyama, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Tetsuo Noda and Yusaku Nakabeppu
- Organizer
  4th US-JAPAN DNA REPAIR MEETING
- Place of Presentation
  Virginia, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 放射線照射によって生成される修飾ヌクレオシドの解析.2012
- Author(s)
  秋本　頼子，中別府　雄作
- Organizer
  第35回日本がん疫学・分子疫学研究会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia.2012
- Author(s)
  Hiroko Nomaru， Noriko Yutsudo， Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 哺乳動物のITP 分解酵素とエンドヌクレアーゼV.2012
- Author(s)
  作見邦彦，土本大介，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] アルツハイマー病脳における遺伝子発現プロファイリング-剖検脳とマウスモデルの比較解析-2012
- Author(s)
  中別府雄作
- Organizer
  グローバルCOEプログラム「個体恒常性を担う細胞運命の決定とその破綻」第5回事業推進担当者発表会
- Place of Presentation
  福岡
- Year and Date
  2012-02-21
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mice lacking fosB display impaired adult hippocampal neurogenesis and spontaneous epilepsy2012
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  The 21st Hot spring Harbor Symposium jointly with 8th Global COE International Symposium, YoungInvestigatorsPresentation
- Place of Presentation
  Fukuoka
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] Quality control in the nucleotide pools is essential for cellular homeostasis2012
- Author(s)
  Yusaku Nakabeppu
- Organizer
  Invited seminar at Laboratory of Molecular Gerontology, National Institute on Aging, NIH
- Place of Presentation
  Baltimore, MD USA
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Altered expression of diabetes-related genes in Alzheimer's disease brains.2012
- Author(s)
  Yusaku Nakabeppu
- Organizer
  11th Surugadai International Symposium
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 放射線照射によって生成されるプリンヌクレオシドの修飾体の同定と定量.2012
- Author(s)
  秋本頼子，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化損傷塩基の修復機構をノックアウトするマウス家系の解析.2012
- Author(s)
  大野みずき，作見邦彦，福村龍太郎，権藤洋一，田口健一，續輝久，中別府雄作
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides.2012
- Author(s)
  Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Nakabeppu Y, Samson LD
- Organizer
  7th Annual CEHS Poster Session
- Place of Presentation
  Cambridge, MA, USA
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2012
- Author(s)
  Nomaru H, Yutsudo N, Hokoma M, Nakabeppu Y
- Organizer
  The Munich Life Science Symposium for Young Scientist 2012
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] fosB 遺伝子産物によるアナフィラトキシン C5a 走化性受容体遺伝子C5ar と Gpr77 の発現制御機構の解析2012
- Author(s)
  能丸寛子, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] Obesity and altered expression of genes related to Diabetes-mellitus in Alzheimer’s disease mouse model.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mice lacking fosB display impaired adult hippocampal neurogenesis and spontaneous epilepsy2012
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H.Ohnishi, Yoshinori N.Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  The 21^<st> Hot spring Harbor Symposium jointly with 8^<th> Global COE International Symposium, Young Investigators Presentation
- Place of Presentation
  Fukuoka
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] fosB 遺伝子産物によるアナフィラトキシンC5a 走化性受容体遺伝子C5ar とGpr77 の発現制御機構の解析2012
- Author(s)
  能丸寛子, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] Obesity and altered expression of genes related to diabetes mellitus in a transgenic mouse model of Alzheimer's disease.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 2-OH-ATP as a signal molecule for the oxidative stress in mammalian cells。2012
- Author(s)
  Eiko Ohta, Kunihiko Sakumi, Daisuke Tsuchimoto, Yuka Takiguchi and Yusaku Nakabeppu
- Organizer
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Place of Presentation
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Alzheimer’s disease mouse model exhibits altered expression of genes related to diabetes-mellitus with obesity.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 筋萎縮性側索硬化症におけるGalectin-1の病態への関与.2012
- Author(s)
  小早川優子，作見邦彦，中別府雄作
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] DNA中のデオキシイノシン量を制御するメカニズム.2012
- Author(s)
  作見邦彦，中別府雄作
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] The molecular neurobiology of anti-oxidative stress induced by hydrogen2011
- Author(s)
  Mami Noda, Kyota Fujita, Mizuho A.Kido, Yusaku Nakabeppu
- Organizer
  7th Congress of the Federation of Asian and Oceanian Physiological Societies (FAOPS)
- Place of Presentation
  Taipei Taiwan(招待講演)
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Roles of insulin in survival and proliferation of SH-SY5Y neuroblastoma cells under neuronal differentiation2011
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Erika Castillo, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 脳内細胞における fosB による遺伝子プロファイルの網羅的解析2011
- Author(s)
  能丸寛子,大西克典,外間政朗,湯通堂紀子,中別府雄作
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2011
- Author(s)
  H. Nomaru, N. Yutsudo, M. Hokoma, Y. Nakabeppu
- Organizer
  41st Annual meeting of Society for Neuroscienc
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAsKeystone Symposia Stem Cells2011
- Author(s)
  Sugako Oka, Yusaku Nakabeppu
- Organizer
  Cancer and Metastasis
- Place of Presentation
  USA
- Year and Date
  2011-03-08
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures2011
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H.Ohnishi, Yoshinori N.Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  Neurogenesis 2011
- Place of Presentation
  Kobe
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
- Author(s)
  Sugako Oka, Julio Leon, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYHはp53による発がん抑制のメディエータである2011
- Author(s)
  岡素雅子, フリオレオン, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  第40回日本環境変異原学会シンポジウム
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
- Author(s)
  Sugako Oka, Julio Leon, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会口頭、ポスター
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] ΔFosB/Δ2ΔFosBは成体海馬神経前駆細胞の増殖制御とてんかん自然発症の抑制に働く2011
- Author(s)
  湯通堂紀子, 鎌田崇嗣, 能丸寛子, 大西(本田)陽子, 大西克典, 梶谷康介, 作見邦彦, 重藤寛史, 中別府雄作
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] マウス黒質における核酸の酸化損傷防御酵素群, MTH1,OGG1,MUTYHの領域特異的な発現2011
- Author(s)
  盛子敬, 中別府雄作
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs.2011
- Author(s)
  Sugako Oka, Yusaku Nakabeppu
- Organizer
  Keystone Symposia on Stem Cells, Cancer and Metastasis
- Place of Presentation
  Keystone, Colorado, USA
- Year and Date
  2011-03-08
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb products regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures2011
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H.Ohnishi, Yoshinori N.Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  2011 International Summer Conference for Neurons and Brain Disease
- Place of Presentation
  Toyama
- Year and Date
  2011-08-04
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
- Author(s)
  Sugako Oka, Julio Leon, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  日本環境変異原学会第40回大会 (シンポジウム)
- Place of Presentation
  東京
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] ΔFosB/Δ2ΔFosB は成体海馬神経前駆細胞の増殖制御とてんかん自然発症の抑制に働く2011
- Author(s)
  湯通堂紀子, 鎌田崇嗣, 能丸寛子, 大西(本田) 陽子, 大西克典, 梶谷康介, 作見邦彦, 重藤寛史, 中別府雄作
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] 酸化ヌクレオチド2-OH-ATPによる細胞死の制御機構2011
- Author(s)
  太田詠子, 土本大介, 作見邦彦, 瀧口友香, 中別府雄作
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2011
- Author(s)
  H. Nomaru, N. Yutsudo, M. Hokoma, Y. Nakabeppu
- Organizer
  41st Annual meeting of Society for Neuroscience
- Place of Presentation
  Washington, DC, USA.
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] Ogg1, Mth1, Mutyh triple knockout mouseの樹立と解析2011
- Author(s)
  作見邦彦, 大野みずき, 田口健一, 外間政朗, 中別府雄作
- Organizer
  「個体レベルでの発がん研究支援活動」ワークショップ
- Place of Presentation
  大津
- Year and Date
  2011-02-03
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Defects of DNA repair systems against oxidative mutagenesis : implication in oxidative-stress induced carcinogenesis2011
- Author(s)
  Yoshimichi Nakatsu, Jing Shu Piao, Takuro Isoda, Kunihiko Sakumi, Yusaku Nakabeppu, Teruhisa Tsuzuki
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 脳内細胞におけるfosBによる遺伝子プロファイルの網羅的解析2011
- Author(s)
  能丸寛子, 大西克典, 外間政朗, 湯通堂紀子, 中別府雄作
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2011
- Author(s)
  H.Nomaru, N.Yutsudo, M.Hokoma, Y.Nakabeppu
- Organizer
  41^<st> Annual meeting of Society for Neuroscience
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 剖検脳マイクロアレイ解析による脳疾患遺伝子発現プロファイリング2011
- Author(s)
  外間政朗, 岩城徹, 清原裕, 佐々木富男, 中別府雄作
- Organizer
  脳神経外科学会第70回学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-10-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb products regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures2011
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  2011 International Summer Conference for Neurons and Brain Disease
- Place of Presentation
  Toyama
- Year and Date
  2011-08-04
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] Hydrogen confers resistance to neuronal loss on dopaminergic neurons in mice model of Parkinson's disease2011
- Author(s)
  K.Fujita, F.Inoue; M.Yamafuji, K.Beppu, M.A.Kido, Y.Tanaka, Y.Nakabeppu, M.Noda
- Organizer
  41^<st> Annual meeting of Society for Neuroscience
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾と生体応答2011
- Author(s)
  中別府雄作, 猪山輝昭, 岡素雅子, 盛子敬, 作見邦彦, 土本大介
- Organizer
  第2回 Molecular Cardiovascular Conference
- Place of Presentation
  余市(招待講演)
- Year and Date
  2011-09-04
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾と生体応答2011
- Author(s)
  中別府雄作
- Organizer
  日本植物学会第75回大会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2011
- Author(s)
  Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  6th Global-COE Young Investigators Forum
- Place of Presentation
  Bintan Isaland, Indonesia.
- Year and Date
  2011-02-12
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb products regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures.2011
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  2011 International Summer Conference for Neurons and Brain Disease
- Place of Presentation
  Toyama
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] アルツハイマー病の分子機構～遺伝子発現機構からのアプローチ2011
- Author(s)
  中別府雄作
- Organizer
  Hisayama Study Conference 2011
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ΔFosB/Δ2ΔFosB は成体海馬神経前駆細胞の増殖制御とてんかん自然発症の抑制に働く2011
- Author(s)
  湯通堂紀子，鎌田崇嗣，能丸寛子，大西（本田）陽子，大西克典，梶谷康介，作見邦彦，重藤寛史，中別府雄作
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] Gene expression prefiling of postmortem brains of patients with Alzheimer's disease pathology : The Hisayama Study2011
- Author(s)
  M.Hokama, T.Iwaki, K.Sasaki, Y.Kiyohara, T.Sasaki, Y.Nakabeppu
- Organizer
  41^<st> Annual meeting of Society for Neuroscience
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2011
- Author(s)
  Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  Keystone Symposia on Genomic Instability and DNA Repair
- Place of Presentation
  Keystone, Colorado, USA.
- Year and Date
  2011-02-01
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物細胞におけるデオキシイノシンヌクレオチドによるゲノム不安定化とその防御機構2011
- Author(s)
  土本大介, 猪山輝昭, アボルハッサニノナ, 米嶋康臣, 作見邦彦, 中別府雄作
- Organizer
  日本遺伝学会第83回大会
- Place of Presentation
  京都
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-OxoguanineはDNA鎖切断を誘発することで減数分裂期の相同染色体組換え頻度を上昇させる2011
- Author(s)
  大野みずき, 作見邦彦, 古市正人, 中西恵美, 續輝久, 中別府雄作
- Organizer
  日本遺伝学会第83回大会
- Place of Presentation
  京都
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである2011
- Author(s)
  岡素雅子, レオンフリオ, 作見邦彦, 土木大介, 中別府雄作
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 脳内細胞におけるfosBによる遺伝子プロファイルの網羅的解析2011
- Author(s)
  能丸寛子，大西克典，外間政朗，湯通堂紀子，中別府雄作
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] 2-OH-ATP as a candidate molecule for the oxidative stress sensor in mammalian cells2011
- Author(s)
  Kunihiko Sakumi, Eiko Ohta, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures.2011
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  Neurogenesis 2011
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
- Author(s)
  Sugako Oka, Julio Leon, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  日本環境変異原学会第40回大会シンポジウム発表
- Place of Presentation
  東京一橋記念講堂
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides and defense systems in mammalian cells2011
- Author(s)
  Daisuke Tsuchimoto, Teruaki Iyama, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures2011
- Author(s)
  Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
- Organizer
  Neurogenesis 2011
- Place of Presentation
  Kobe
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-23657116
[Presentation] 8-Oxoguanine, a spontaneously oxidized guanine base, promotes somatic and meiotic recombination, thus contributing to carcinogenesis and genomic diversity2011
- Author(s)
  Yusaku Nakabeppu
- Organizer
  The 5th Biennial Meetin of Society for Free Radical Research-Asia (SFRR-Asia), 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), and 11th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit)
- Place of Presentation
  Kagoshima(招待講演)
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ストレスはDNA修復酵素MUTYHに依存して神経変性を引き起こす2011
- Author(s)
  盛子敬, 岡素雅子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第4回Kyushu CVD Conference
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ヌクレオチド2-OH-ATPによる細胞死の制御機構2010
- Author(s)
  太田詠子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs2010
- Author(s)
  Sugako Oka, Julio Leon, Yusaku Nakabeppu
- Organizer
  国際3R会議
- Place of Presentation
  富山
- Year and Date
  2010-10-27
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] NUDT16は(デオキシ)イノシン二リン酸分解酵素であり,その欠損は核DNAの一本鎖切断の蓄積と増殖抑制をもたらす2010
- Author(s)
  土本大介, 猪山輝昭, アボルハッサニノナ, 野中麻里, 中別府雄作
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] The biological significance of ITPA protein and its substrates, ITP and dITP in mouse2010
- Author(s)
  Kunihiko Sakumi, Nona Abolhassani, Mehrdad Behmanesh, Teruaki Iyama, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Base excision repair-mediated programmed cell death and neurodegeneration2010
- Author(s)
  Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
- Organizer
  3rd International Genome Dynamics in Neurosciences Conference "DNA Repair and Neurological disease"
- Place of Presentation
  Brighton, UK
- Year and Date
  2010-07-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH, a molecular switch for programmed cell death and tumor suppression2010
- Author(s)
  S Oka, Y Nakabeppu
- Organizer
  AACR/JCA 8th Joint Conference
- Place of Presentation
  Waikoloa, Hawai, USA
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs.2010
- Author(s)
  Sugako Oka, Zijing Sheng, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 核酸の酸化がもたらす生体障害とその防御機構2010
- Author(s)
  中別府雄作
- Organizer
  第26回臨床フリーラジカル会議
- Place of Presentation
  大津
- Year and Date
  2010-01-30
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYH, a molecular switch for programmed cell death and tumor suppression.2010
- Author(s)
  S Oka, Y Nakabeppu
- Organizer
  AACR/JCA 8th Joint Conference
- Place of Presentation
  Waikoloa, Hawai, USA
- Year and Date
  2010-02-07
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYHはp53による発がん抑制のメディエータである2010
- Author(s)
  岡素雅子, 中別府雄作
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quality control in the purine nucleotide pools is essential for maintaining genomic integrity in mammals.2010
- Author(s)
  Yusaku Nakabeppu, Nona Abolhassani, Teruaki Iyama, Zijing Sheng, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2010
- Author(s)
  Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Mari Nonaka, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾と生体応答2010
- Author(s)
  中別府雄作
- Organizer
  第51回日本生化学会中国・四国支部例会シンポジウム
- Place of Presentation
  山口
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-22241013
[Presentation] Molecular mechanisms for oxidative DNA damage-induced neurodegeneration.2010
- Author(s)
  Yusaku Nakabeppu
- Organizer
  The 7th Conference of Asian Society for Mitochondrial Research and Medicine
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2010
- Author(s)
  Sugako Oka, Yusaku Nakabeppu
- Organizer
  第69回日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻に起因するゲノム障害とその防御機構2010
- Author(s)
  中別府雄作, Nona Abolhassani, 猪山輝昭, 太田詠子, 盛子敬, 岡素雅子, 土本大介, 作見邦彦
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Deoxyinosine incorporated into DNA under ITPA deficiency2010
- Author(s)
  Nona Abolhassani, Teruaki Iyama, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
- Author(s)
  Nona Abolhassani, Teruaki Iyama, Daisuke Tsuchimoto, Kunihiko Sakumi, Mizuki Ohno, Mehrdad Behmanesh, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性酸素による核酸の損傷と神経変性の機序2010
- Author(s)
  中別府雄作
- Organizer
  第3回 Kyushu CVD Conference
- Place of Presentation
  福岡
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである2010
- Author(s)
  岡素雅子, フリオレオン, 中別府雄作
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice2010
- Author(s)
  Teruhisa Tsuzuki, Jing Shu Piao, Takuro Isoda, Kunihiko Sakumi, Yusaku Nakabeppu, Yoshimichi Nakatsu
- Organizer
  Bond Workshop : Biological effects of low-level exposure to ionizing radiation, health risks and clinical consequences
- Place of Presentation
  Richland, Washington, USA
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-22241013
[Presentation] Mitochondrial toxin, 3-nitropropionic acid induces striatal degeneration through the two distinct MUTYH-dependent cell death pathways.2010
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-oxoguanineはDNA 鎖切断を誘発することで減数分裂期の相同染色体組換え頻度を上昇させる2010
- Author(s)
  大野みずき, 作見邦彦, 續輝久, 中別府雄作
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態2010
- Author(s)
  中別府雄作, 猪山輝昭, Nona Abolhassani, 太田詠子, 盛子敬, 岡素雅子, 作見邦彦, 土本大介
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾と生体応答2010
- Author(s)
  中別府雄作
- Organizer
  第51回日本生化学会中国・四国支部例会シンポジウム
- Place of Presentation
  山口
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである2010
- Author(s)
  岡素雅子、レオンフリオ、中別府雄作
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22501014
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2009
- Author(s)
  S Oka, Y Nakabeppu
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Oxidative genomic damage in brain and neuroprotection.2009
- Author(s)
  Yusaku Nakabeppu
- Organizer
  The Joint Symposium of the 4th International Symposium of Institutes Network and Osaka University Global COE (Frontier Biomedical Science Underlying Organelle Network Biology) Symposium
- Place of Presentation
  Osaka
- Year and Date
  2009-02-01
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYH is a potential mediator of p53 tumor suppression.2009
- Author(s)
  S Oka, J J Leon-Incio, Y Nakabeppu
- Organizer
  第33回日本分子生物学会年会/第83回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 8-Oxoguanine promotes base substitution and homologous recombination in mammalian germ cells.2009
- Author(s)
  M Ohno, M Furuichi, K Sakumi, Y Nakabeppu
- Organizer
  The 3rd ASM Conference on DNA Repair and Mutagenesis: From Molecular Structure to Human Disease
- Place of Presentation
  Whistler, Canada
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Base excision repair-mediated programmed cell death responsible for tumor suppression and neurodegeneration2009
- Author(s)
  Y Nakabeppu, S Oka, Z Sheng, D Tsuchimoto, K Sakumi
- Organizer
  4th International Workshop on Cell Regulations in Division and Arrest
- Place of Presentation
  Okinawa
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYH is a potential mediator of p53 tumor suppression2009
- Author(s)
  S Oka, J J Leon-Incio, Y Nakabeppu
- Organizer
  第33回日本分子生物学会年会/第83回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYH, A MOLECULAR SWITCH FOR PROGRAMMED CELL DEATH AND TUMOR SUPPRESSION2009
- Author(s)
  S Oka, M Ohno, D Tsuchimoto, K Sakumi, Y Nakabeppu
- Organizer
  The Fortieth International Symposium of The Princess Takamatsu Cancer Research Fund
- Place of Presentation
  Tokyo
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 8-Oxoguanine promotes base substitution and homologous recombination in mammalian germ cells2009
- Author(s)
  M Ohno, M Furuichi, K Sakumi, Y Nakabeppu
- Organizer
  The 3rd ASM Conference on DNA Repair and Mutagenesis
- Place of Presentation
  Whistler, Canada
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 核酸の酸化と細胞死のシグナル伝達2009
- Author(s)
  中別府雄作
- Organizer
  大阪大学蛋白質研究所セミナー
- Place of Presentation
  大阪
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 酸化損傷塩基の修復能を欠損するマウスにおける継世代的影響の解析2009
- Author(s)
  大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
- Organizer
  日本遺伝学会第81回大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 酸化的DNA損傷と生殖細胞ゲノム変異2009
- Author(s)
  大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
- Organizer
  日本環境変異原学会
- Place of Presentation
  静岡
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Oxidative damage in nucleic acids and mitochondrial dysfunction2009
- Author(s)
  Y Nakabeppu
- Organizer
  SFRR International Summer School 2009 in Japan
- Place of Presentation
  Minamiuonuma
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 酸化的DNA損傷と生殖細胞ゲノム変異2009
- Author(s)
  大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
- Organizer
  日本放射線影響学会第52回大会
- Place of Presentation
  広島
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Identification of the full-length form of Prune2, a neuroblastoma-related protein.2009
- Author(s)
  aisuke Tsuchimoto, Eiji Iwama, Teruaki Iyama, Yusaku Nakabeppu
- Organizer
  2009年第32回日本神経科学大会
- Place of Presentation
  愛知県名古屋市名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Oxidative Stress-Induced Tumorigenesis in the Small Intestine of Various DNA Repair-Deficient Mice2009
- Author(s)
  T Tsuzuki, J Piao, T Isoda, K Sakumi, Y Nakabeppu, Y Nakatsu
- Organizer
  The 3rd ASM Conference on DNA Repair and Mutagenesis
- Place of Presentation
  Whistler, Canada
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Mitochondrial toxin, 3-nitropropionic acid induces MUTYH-dependent striatal degeneration.2009
- Author(s)
  Z Sheng, H Yamada, Y Nakabeppu.
- Organizer
  第32回日本神経科学会大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYH, A MOLECULAR SWITCH FOR PROGRAMMED CELL DEATH AND TUMOR SUPPRESSION2009
- Author(s)
  S Oka, M Ohno, D Tsuchimoto, K Sakumi, Y Nakabeppu
- Organizer
  The Fortieth International Symposium of The Princess Takamatsu Cancer Research Fund
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Base excision repair-mediated programmed cell death responsible for tumor suppression and neurodegeneration2009
- Author(s)
  Y Nakabeppu, S Oka, Z Sheng, D Tsuchimoto, K Sakumi
- Organizer
  4th International Workshop on Cell Regulations in Division and Arrest
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Human NUDT16 Is a Novel Nucleotide Pool Sanitizing Enzyme Hydrolyzing (Deoxy)Inosine Diphosphate to (Deoxy)Inosine Monophosphate.2009
- Author(s)
  Teruaki Iyama, Daisuke Tsuchimoto, Nona Abolhassani, Yusaku Nakabeppu
- Organizer
  The 49th annual meeting of the American Society for Cell Biology, San Diego Convention Center, San Diego
- Place of Presentation
  CA, USA
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] MUTYH, a molecular switch for programmed cell death under oxidative stress-friend or foe?2009
- Author(s)
  Yusaku Nakabeppu
- Organizer
  The 3rd Global COE International Symposium on Stem Cells and Regenerative Medicine
- Place of Presentation
  Singapore
- Year and Date
  2009-02-15
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Production and analysis of the Ogg1, Mth1, Mutyh triple knockout mouse strain2009
- Author(s)
  K Sakumi, M Ohno, K Taguchi, M Hokama, Y Nakatsu, T Tsuzuki, Y Nakabeppu
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Oxidative damage in nucleic acids and mitochondrial dysfunction.2009
- Author(s)
  Y Nakabeppu
- Organizer
  SFRR International Summer School 2009 in Japan
- Place of Presentation
  Minamiuonuma
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] ヒトnudt16は(デオキシ)イノシン二リン酸を(デオキシ)イノシン一リン酸に加水分解する新規ヌクレオチドプール浄化酵素である2009
- Author(s)
  土本大介、猪山輝昭、アボルハッサニ・ノナ、中別府雄作
- Organizer
  2009年第20回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  滋賀県彦根市琵琶湖コンファレンスセンター
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] 核酸の酸化とプログラム細胞死2009
- Author(s)
  中別府雄作
- Organizer
  レドックス170委員会第20回研究会
- Place of Presentation
  名古屋
- Year and Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Programmed cell death triggered by nucleotide pool damage.2009
- Author(s)
  Y Nakabeppu, E Ohta, J Ichikawa, D Tsuchimoto
- Organizer
  The 10th International Conference on Environmental Mutagenesis (ICEM)
- Place of Presentation
  Italy
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYH-dependent cell death and neurodegeneration2009
- Author(s)
  Z Sheng, S Oka, Y Nakabeppu
- Organizer
  The 2nd Erling Seeberg symposium on DNA repair
- Place of Presentation
  Alesund-Geiranger, Norway
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYH-dependent cell death and neurodegeneration2009
- Author(s)
  Z Sheng, S Oka, Y Nakabeppu
- Organizer
  The 2nd Erling Seeberg symposium on DNA repair
- Place of Presentation
  Norway
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Programmed cell death triggered by nucleotide pool damage2009
- Author(s)
  Y Nakabeppu, E Ohta, J Ichikawa, D Tsuchimoto
- Organizer
  The 10th International Conference on Environmental Mutagenesis
- Place of Presentation
  Firenze, Italy
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 酸化ヌクレオチドによるシグナル伝達2009
- Author(s)
  太田詠子, 土本大介, 中別府雄作
- Organizer
  第62回日本酸化ストレス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Oxidative damage in brain genome and neuroprotection.2009
- Author(s)
  Yusaku Nakabeppu
- Organizer
  The 11th Meeting of Hirosaki International Forum of Medical Science Emerging Frontiers in Brain Research -Crossroads of metabolic regulation, stress response and disease
- Place of Presentation
  Hirosaki
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Overview of programmed cell death and oxidative stress.2008
- Author(s)
  中別府雄作
- Organizer
  第8回日本ミトコンドリア学会年会
- Place of Presentation
  東京
- Year and Date
  2008-12-18
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] The mitochondrial toxin, 3-nitropropionic acid induces MUTYH-dependent striatal neurodegeneration with accumulation of 8-oxoguanine which is effectively suppressed by OGG1 and MTH1.2008
- Author(s)
  Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
- Organizer
  The 5th ASMRM and Chinese Mit'2008
- Place of Presentation
  Tianjin, China
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 8-オキソグアニンは染色体組換えを促進し, ゲノム多様性の原因となる2008
- Author(s)
  大野みずき, 作見邦彦, 中別府雄作
- Organizer
  日本遺伝学会第80回大会
- Place of Presentation
  名古屋
- Year and Date
  2008-09-04
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] OGG1 and MTH1 effectively suppress accumulation of 8-oxoguanine in striatal medium spiny neurons and their degeneration induced by mitochondrial toxin, 3-nitropropionic acid.2008
- Author(s)
  Sheng Zijing, Hidetaka Yamada, Yusaku Nakabeppu
- Organizer
  第31回日本神経科学会大会
- Place of Presentation
  東京
- Year and Date
  2008-07-09
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] OGG1/MTH1/MUTYH三重欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す2008
- Author(s)
  大野みずき, 作見邦彦, 古市正人, 中別府雄作
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 新規損傷ヌクレオチド浄化酵素ITPBP2の同定と機能解析2008
- Author(s)
  土本大介、吉田菜桜子、中別府雄作
- Organizer
  2008年第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] 哺乳動物細胞における2-OH-ATPの生物学的影響2008
- Author(s)
  太田詠子、土本大介、大野みずき、作見邦彦、中別府雄作
- Organizer
  2008年第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] DNA修復関連遺伝子欠損マウスにおける酸化ストレス誘発消化管発がん2008
- Author(s)
  中津可道, 朴晶淑, 磯田拓郎, 續輝久, 作見邦彦, 中別府雄作
- Organizer
  がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
- Place of Presentation
  福岡
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Overview of programmed cell death and oxidative stress2008
- Author(s)
  中別府雄作
- Organizer
  第8回日本ミトコンドリア学会年会
- Place of Presentation
  東京
- Year and Date
  2008-12-18
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] MUTYHは核とミトコンドリアDNA中の8-オキソグアニンの制御により2つの異なる細胞死経路を引き起こす2008
- Author(s)
  岡素雅子, 大野みずき, 土本大介, 作見邦彦, 古市正人, 中別府雄作
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 8-Oxoguanine is a major cause for the genome instability and diversity through enhancing the somatic and meiotic recombination.2008
- Author(s)
  Mizuki Ohno, Yusaku Nakabeppu
- Organizer
  日本環境変異原学会第37回大会
- Place of Presentation
  宜野湾
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Novel pathway for hydrolysis of inosine nucleotides detected in immortalized ITPA-null mouse embryo fibroblasts2008
- Author(s)
  アボルハッサニ・ノナ、作見邦彦、大野みずき、土本大介、ベーマネッシュ・メールダート、中別府雄作
- Organizer
  2008年第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] 8-Oxoguanine promotes genetic diversity through enhancing meiotic recombination2008
- Author(s)
  Mizuki Ohno, Masato Furuichi, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  XX International Congress of Genetics
- Place of Presentation
  Berlin, Germany
- Year and Date
  2008-07-12
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] OGG1/MTH1/UTYH三重欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す2008
- Author(s)
  大野みずき, 作見邦彦, 古市正人, 中別府雄作
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 核とミトコンドリアゲノムへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死2008
- Author(s)
  岡素雅子、大野みずき、土本大介、作見邦彦、中別府雄作
- Organizer
  2008年第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] MUTYHは核とミトコンドリアDNA中の8-オキソグアニンの制御により2つの異なる細胞死経路を引き起こす2008
- Author(s)
  岡素雅子, 大野みずき, 土本大介, 作見邦彦, 古市正人, 中別府雄作
- Organizer
  第67回日本癌学会学術総会(シンポジウム)
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 核とミトコンドリアDNAへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死2008
- Author(s)
  岡素雅子, 大野みずき, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] ミトコンドリア毒3-ニトロプロピオン酸は8-オキソグアニンの蓄積を伴うMUTYH依存性の線条体変性を誘発するが, MTH1とOGG1により抑制される2008
- Author(s)
  中別府雄作, 盛子敬, 岡素雅子
- Organizer
  第8回日本ミトコンドリア学会年会
- Place of Presentation
  東京
- Year and Date
  2008-12-20
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Msh2遺伝子欠損マウスにおける酸化ストレス誘発小腸腫瘍の解析2008
- Author(s)
  朴晶淑, 中津可道, 磯田拓郎, 續輝久, 作見邦彦, 中別府雄作
- Organizer
  がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
- Place of Presentation
  福岡
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] ミトコンドリアヌクレオチドプールの酸化に起因する細胞死とその防御機構2008
- Author(s)
  中別府雄作, 市川淳二, 岡素雅子, 大野みずき, 太田詠子, 土本大介, 作見邦彦
- Organizer
  第61回日本酸化ストレス学会
- Place of Presentation
  京都
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 8-Oxoguanine, a major form of spontaneously oxidized guanine base, promotes genome diversity through enhancing chromosome recombination.2008
- Author(s)
  Mizuki Ohno, Yusaku Nakabeppu
- Organizer
  The 6th 3R (Replication, recombination, repair) Symposim
- Place of Presentation
  Kakegawa
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 活性酸素によるゲノム障害とその防御機構-発がんと神経変性の分子病態-2008
- Author(s)
  中別府雄作
- Organizer
  第27回分子病理学研究会
- Place of Presentation
  神奈川県三浦郡葉山町
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Ogg1/Mth1/Mutyh三重遺伝子欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す2008
- Author(s)
  野みずき, 作見邦彦, 古市正人, 中別府雄作
- Organizer
  日本遺伝学会第80回大会
- Place of Presentation
  名古屋
- Year and Date
  2008-09-03
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 核とミトコンドリアDNAへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死2008
- Author(s)
  岡素雅子, 大野みずき, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Ogg1, Mth1, Mutyhの3重遺伝子欠損マウス系統のミュテーター・フェノタイプに起因した遺伝性水頭症2008
- Author(s)
  外間政朗, 大野みずき, 作見邦彦, 佐々木富男, 中別府雄作
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Oxidation of mitochondrial deoxynucleotide pools induces mitochondrial degeneration and cell death.2008
- Author(s)
  Junji Ichikawa, Daisuke Tsuchimoto, Sugako Oka, Mizuki Ohno, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  The 7th European Meeting on Mitochondrial Pathology, Stockholm
- Place of Presentation
  Sweden.
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 活性酸素によるゲノム障害とその防御機構2008
- Author(s)
  中別府雄作
- Organizer
  第3回放射線防護研究センターシンポジウム(独立行政法人放射線医学総合研究所)「生き物はどのようにして放射線に立ち向かうか-DNA損傷応答と適応応答-」
- Place of Presentation
  千葉
- Year and Date
  2008-12-16
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.2008
- Author(s)
  Sugako Oka, Mizuki Ohno, Daisuke Tsuchimoto, Kunihiko Sakumi, Masato Furuichi, Yusaku Nakabeppu
- Organizer
  The 7th European Meeting on Mitochondrial Pathology, Stockholm
- Place of Presentation
  Sweden
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] 8-オキソグアニンは染色体組換えを誘発する2008
- Author(s)
  大野みずき, 作見邦彦, 中別府雄作
- Organizer
  がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
- Place of Presentation
  福岡
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-20013034
[Presentation] Defenses against damage in nucleotide pools and suppression ofcarcinogenesis, neurodegeneration and heart failure.2007
- Author(s)
  Nakabeppu Y, et. al.
- Organizer
  38thAnnual Meeting of the Environmental Mutagen Society
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2007-10-22
- Data Source
  KAKENHI-PROJECT-18013038
[Presentation] Cell death caused by 8-oxoguanine2007
- Author(s)
  Nakabeppu Y.
- Organizer
  3rd Japan-US DNA Repair Meeting
- Place of Presentation
  Akiu,Sendai
- Year and Date
  2007-05-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Mice that express only DFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity2007
- Author(s)
  Nakabeppu, Y., et. al.
- Organizer
  The 30th Annual Meeting of the Canadian College of Neuropsychopharmacology
- Place of Presentation
  Banff, Alberta, Canada
- Year and Date
  2007-06-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Disruption of Defense Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polynhenols2007
- Author(s)
  Nakabeppu, Y
- Organizer
  3rd International Conference on Polyphenol and Health
- Place of Presentation
  Kyoto
- Year and Date
  2007-10-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Mice that express only ΔFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity2007
- Author(s)
  Nakabeppu Y., et. al.
- Organizer
  30th Annual Meeting of the Canadian College of Neurpsychoharmacology(CCNP)
- Place of Presentation
  Banff,Alberm,Canada
- Year and Date
  2007-06-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Mice that express only ΔFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity2007
- Author(s)
  Nakabeppu Y, et. al.
- Organizer
  30^<th> Annual Meeting of the Canadian College of Neuropsychopharmacology(CCNP)
- Place of Presentation
  Banff, Alberta, Canada
- Year and Date
  2007-06-10
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Defenses against damage in nucleotide pools and the suppression of carcinogenesis,neurodegeneration and heart failure.2007
- Author(s)
  Nakabeppu Y, et. al.
- Organizer
  38^<th> Annual Meeting of the Environmental Mutagen Society
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2007-10-22
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Disruption of Defbnce Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polyphenols2007
- Author(s)
  Nakabeppu Y., et. al.
- Organizer
  3rd International Confbrence on Polyphenol and Health
- Place of Presentation
  Kyoto
- Year and Date
  2007-10-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Cell death caused by 8-oxoguanine2007
- Author(s)
  Nakabeppu Y
- Organizer
  3^<rd> Japan-US DNA Repair Meeting
- Place of Presentation
  Akiu, Sendai
- Year and Date
  2007-05-08
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] ITP結合タンパク質ITPBP1の生化学的特性の解析2007
- Author(s)
  野中麻里、土本大介、太田詠子、作見邦彦、中別府雄作
- Organizer
  2007年第30回日本分子生物学会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Disruption of Defence Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polyphenols.2007
- Author(s)
  Nakabeppu Y, et. al.
- Organizer
  3^<rd> International Conference on Polyphenol and Health
- Place of Presentation
  Kyoto
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Disruption of Defence Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polyphenols.2007
- Author(s)
  Nakabeppu Y, et. al.
- Organizer
  3^<td> International Conference on Polyphenol and Health
- Place of Presentation
  Kyoto
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Cell death caused by 8-oxoguanine2007
- Author(s)
  Nakabeppu, Y
- Organizer
  3rd Japan-US DNA Repair Meeting, Akiu
- Place of Presentation
  Sendai
- Year and Date
  2007-05-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Celldeath caused by 8-oxoguanine2007
- Author(s)
  Nakabeppu, Y
- Organizer
  3rdJapan-US DNA Repair Meeting
- Place of Presentation
  Akiu, Sendai,
- Year and Date
  2007-05-08
- Data Source
  KAKENHI-PROJECT-18013038
[Presentation] Defbnses against damage in nucleotide pools and the suppression of carcinogenesis,neurodegeneration and heart failure2007
- Author(s)
  Nakabeppu Y., et. al.
- Organizer
  38th Annual Meeting of the Environmental Mutagcn Society
- Place of Presentation
  Atlanta,GA,USA
- Year and Date
  2007-10-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Nitric oxide induces cell death through oxidation of mitochondrial deoxynucleotide pools.2007
- Author(s)
  市川淳二、土本大介、岡素雅子、大野みずき、作見邦彦、中別府雄作
- Organizer
  2007年第30回日本分子生物学会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Cell death caused by 8-oxoguanine2007
- Author(s)
  Nakabeppu Y
- Organizer
  3^<rd> Japan-US DNA Repair Meeting
- Place of Presentation
  Akiu, Sendai
- Year and Date
  2007-05-08
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Defenses against damage in nucleotide pools and the suppression of carcinogenesis,neurodegeneration and heart failure.2007
- Author(s)
  Nakabeppu Y, et. al.
- Organizer
  38^<th> Annual Meeting of the Environmental Mutagen Society
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2007-10-22
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Defenses against Oxidative Damage in Nucleic Acids and the Suppression of Carcinogenesis and Neurodegeneration2006
- Author(s)
  Nakabeppu, Y
- Organizer
  The 17th Chugoku & Shikoku Forum on Bioradicals
- Place of Presentation
  Okayama
- Year and Date
  2006-07-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] 8-オキソグアニンとヒトゲノムの多様性2006
- Author(s)
  中別府雄作
- Organizer
  日本遺伝学会第78回大会
- Place of Presentation
  つくば
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] 活性酸素による核酸の化学修飾と様々な生命現象2006
- Author(s)
  中別府雄作
- Organizer
  変異機構研究会・第19回夏の学校
- Place of Presentation
  瀬戸
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] ITPase is a quality controller of the ATP pool2006
- Author(s)
  Nakabeppu, Y
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress, Satellite Symposium on Frontiers in Redox Sciences
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Biological significance of mechanisms sanitizing nucleotide pools2006
- Author(s)
  Nakabeppu, Y
- Organizer
  Biological significance of mechanisms sanitizing nucleotide pools
- Place of Presentation
  Sapporo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] ITPase is a quality controller of the ATP pool2006
- Author(s)
  Nakabeppu Y.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress, Satellite Symposium on Frontiers in Redox Sciences
- Place of Presentation
  京都
- Year and Date
  2006-06-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Biological responses to chemical modification of nucleic acids caused by reactive oxigen snecies2006
- Author(s)
  Nakabeppu, Y
- Organizer
  The 19th Summer School of Mutagenesis
- Place of Presentation
  Seto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] ヌクレオチドプール浄化機構の生物学的意義2006
- Author(s)
  中別府雄作
- Organizer
  日本放射線影響学会第49回大会
- Place of Presentation
  札幌
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] 核酸の酸化による生体障害とその防御機構-発がんから神経変性まで-2006
- Author(s)
  中別府雄作
- Organizer
  第17回中国四国生体ラジカル研究会
- Place of Presentation
  岡山
- Year and Date
  2006-07-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] 放射線照射によって生成される損傷プリンヌクレオシドの同定と定量
- Author(s)
  秋本頼子, Nona Abolhassani, Erika Castillo, 岡素雅子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] The human NEI endonuclease VIII-like 3 (NEIL3) is a novel gene associated with the development of auto-antibodies
- Author(s)
  Michel J. Massaad, Daisuke Tsuchimoto, Janet Chou, Toshiro Ohsumi, Jia Zhou, Haifa Jabara, Jennifer Kane, Klaus Schmitz, Markianos Kyriacos, Kumiko Torisu, Yusaku Nakabeppu, Peter Kang, Eliane Choueiry, Andre Megarbane, Masayuki Mizui, George Tsokos, Waleed El-Herz, Luigi Notarangelo, Susan Wallace, Raif S. Geha
- Organizer
  16th Biennial Meeting of the European Society for Immunodeficiency
- Place of Presentation
  Prague，Czech Republic
- Year and Date
  2014-10-29 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Masaaki Hokama, Atsuhisa Katogi1, Kunihiko Sakumi, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  日本　東京
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Diversity of human genome and 8-oxoguanine
- Author(s)
  Nakabeppu, Y
- Organizer
  The 78th Annual Meeting of the Genetic Society of Japan
- Place of Presentation
  Tsukuba
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] Microglial activation by Fosb gene.
- Author(s)
  Hiroko Nomaru, Kunihiko Sakumi, Atsuhisa Katogi, Yoshinori N Ohnishisi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  International Symposium between Kyushu University Post-Global Centers of Excellence Program and School of Biomedical Sciences, Monash University
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Defenses against damage in nucleotide pools and the suppression of carcinogenesis, neurodegeneration and heart failure
- Author(s)
  Y., Nakabeppu
- Organizer
  38th Annual Meeting of the Environmental Mutagen Society
- Place of Presentation
  Atlanta, GA, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300124
[Presentation] DNA酸化損傷修復欠損マウスの継代実験で捉えられた遺伝現象
- Author(s)
  作見邦彦, 大野みずき, 福村龍太郎, 権藤洋一, 岩﨑裕貴, 池村淑道, 續輝久, 中別府雄作
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia
- Author(s)
  Hiroko Nomaru, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] アルツハイマー病脳における糖尿病関連遺伝子の発現異常とその意義：久山町研究
- Author(s)
  外間正朗, 岡素雅子, Julio Leon, 二宮利治, 本田裕之, 佐々木健介, 岩城徹, 小原知之, 清原裕, 中別府雄作
- Organizer
  56回歯科基礎医学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物ゲノムにおける8-オキソグアニンの修復プロセッシングと細胞運命
- Author(s)
  岡素雅子, 盛子敬, 作見邦彦, 中別府雄作
- Organizer
  第37回日本分子生物学会ワークショップ
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  岡素雅子, Julio Leon, 加藤木敦央, 作見邦彦, 井手友美, 康東天, 中別府雄作
- Organizer
  第14回日本ミトコンドリア学会年会
- Place of Presentation
  福岡
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Oxidation of nucleic acids by reactive oxygen species and control mechanisms of genetic diversity in mammals.
- Author(s)
  Yusaku Nakabeppu, Mizuki Ohno, Kunihiko Sakumi
- Organizer
  International Symposium between Kyushu University Post-Global Centers of Excellence Program and School of Biomedical Sciences, Monash University
- Place of Presentation
  Melbourne, Australia
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  The 14th Annual Conference of Japanese Society of Mitochondrial Research and Medicine
- Place of Presentation
  福岡
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  岡素雅子, Julio Leon, 加藤木敦央, Erika Castillo, Nona Abolhassani, 作見邦彦, 井手友美, 康東天, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Protective effect of new medical gas against parkinson’s disease
- Author(s)
  Mami Noda, Akio Matsumoto, Megumi Yamafuji, Taikai Inoue, Tomoko Tachibana, Haruyuki Nakaya, Yusaku Nakabeppu
- Organizer
  International Congress on Neurosciences in Krasnoyarsk
- Place of Presentation
  Krasnoyarsk，Russia
- Year and Date
  2014-06-19 – 2014-06-21
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Control mechanisms of genetic diversity and programed cell death induced by 8-oxoguanine in mammals
- Author(s)
  Yusaku Nakabeppu, Mizuki Ohno, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  9th ３R (Replication, Repair, recombination) symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] Impaired insulin production and insulin signaling accompanied by mitochondrial dysfunction in Alzheimer's disease brains: The Hisayama Study
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Julio Leon, Nona Abolhassani, Masaaki Hokama, Toru Iwaki, Yutaka Kiyohara, Dongchon Kang
- Organizer
  包括型脳科学研究推進支援ネットワーク・冬のシンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in a mouse model of Alzheimer’s disease
- Author(s)
  Sugako Oka, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  The Alzheimer’s Association International Conference in Boston, United States, 2013.
- Place of Presentation
  BOSTON USA
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Analysis of Fosb(F/F) mice expressing only FOSB and vFOSB but not ΔFOSB and Δ2ΔFOSB
- Author(s)
  Atsuhisa Katogi, Hiroko Nomaru, Yoshinoro Ohnishi, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  Neuro2013
- Place of Presentation
  日本　京都
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Analysis of FosbF/F mice expressing only FOSB and vFOSB.
- Author(s)
  Atsuhisa Katogi, Hiroko Nomaru, Yoshinori N. Ohnishi, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  International Meeting on Mitochondrial Pathology
- Place of Presentation
  Tampere，Finland
- Year and Date
  2014-06-15 – 2014-06-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  EuroMit International Meeting on Mitochondrial Pathology 2014
- Place of Presentation
  Finland,
- Year and Date
  2014-06-15 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] 8-oxoguanine に起因するde novo germline mutation の解析
- Author(s)
  作見邦彦, 大野みずき, 福村龍太郎, 権藤洋一, 岩﨑裕貴, 池村淑道, 續輝久, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-dependent programed cell death induced by 8-oxoguanine accumulated in cellular DNAs and its implication in tumorigenesis and neruodegeneration
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  5th US-Japan DNA Repair Meeting
- Place of Presentation
  鳴門市
- Year and Date
  2014-10-28 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in a mouse model of Alzheimer’s disease
- Author(s)
  Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  第27回変異機構研究会
- Place of Presentation
  愛知
- Year and Date
  2014-06-21 – 2014-06-22
- Invited
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Dongchon Kang
- Organizer
  The 3rd International Conference and Exhibition on Neurology & Therapeutics
- Place of Presentation
  Philadelphia, PA，U. S. A.
- Year and Date
  2014-09-08 – 2014-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mechanism by which 8-oxoguanine causes dopaminergic neurodegeneration in aged mice
- Author(s)
  Zijing Sheng, Yusaku Nakabeppu
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] Fosb遺伝子産物はマクロファージにおける補体C5a受容体遺伝子，C5ar1とC5ar2の発現を制御する
- Author(s)
  森岡紀子, 能丸寛子, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quality Control of Nucleotide Pools is Essential for Cellular Homeostasis
- Author(s)
  Yusaku Nakabeppu
- Organizer
  Invited seminar at Institute of Molecular Cancer Research University of Zurich
- Place of Presentation
  Zurich, Switzerland.
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHによって開始される塩基除去修復に依存した２つの独立したプログラム細胞死の経路
- Author(s)
  岡素雅子, 盛子敬, 中別府雄作
- Organizer
  日本遺伝学会　第86回大会
- Place of Presentation
  長浜
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] Interspecies comparative gene expression profiling revealed impaired insulin production and insulin signaling accompanied by mitochondrial dysfunction in Alzheimer's disease brains: The Hisayama Study
- Author(s)
  Sugako Oka, Julio Leon, Nona Abolhassani, Masaaki Hokama, Toru Iwaki, Yutaka Kiyohara, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  第88回薬理学会年会シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Control mechanisms of genetic diversity and programed cell death induced by 8-oxoguanine in mammals
- Author(s)
  Yusaku Nakabeppu, Mizuki Ohno, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  9th ３R (Replication, Repair, recombination) symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-11 – 2014-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物ゲノムにおける8-オキソグアニンの修復プロセッシングと細胞運命
- Author(s)
  岡素雅子, 盛子敬, 作見邦彦, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] Impaired insulin production/signaling accompanied by mitochondrial dysfunction and oxidative stress in Alzheimer's disease brains
- Author(s)
  Sugako Oka, Julio Leon, Masaaki Hokama, Toru Iwaki, Yutaka Kiyohara, Dongchon Kang, Yusaku Nakabeppu
- Organizer
  Progress 100: Kyushu-U and Stanford-U Joint Research and Education Program: First Symposium: From Genes to Human Diseases
- Place of Presentation
  福岡
- Year and Date
  2015-03-16 – 2015-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Characterization of transcript variants expressed in Alzheimer’s disease brains with human transcriptome array and deep RNA sequencing analyses: The Hisayama Study
- Author(s)
  Nona Abolhassani, Masasaki Hokama, Toru Iwaki, Yutaka Kiyohara, Yusaku Nakabeppu
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Indoxyl sulfate, a potential uremic neurotoxin, causes accumulation of 8-oxoguanine in mitochondrial DNA in differentiated SH-SY5Y cells
- Author(s)
  Naoki Haruyama, Kumiko Torisu, Ki-ichiro Fujisaki, Kazuhiko Tsuruya, Takanari Kitazono, Yusaku Nakabeppu
- Organizer
  The American Society of Nephrology Annual Meeting
- Place of Presentation
  Philadelphia, PA, U.S.A
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHによって開始される塩基除去修復に依存した２つの独立したプログラム細胞死の経路
- Author(s)
  岡素雅子, 盛子敬, 中別府雄作
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Accumulation of deoxyinosine triphosphate induces mismatch repair-dependent cell growth arrest and instability of genomic DNA.
- Author(s)
  Yasuto Yoneshima, Daisuke Tsuchimoto, Nona Abolhassani, Teruaki Iyama, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Yusaku Nakabeppu
- Organizer
  International Symposium between Kyushu University Post-Global Centers of Excellence Program and School of Biomedical Sciences, Monash University
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice
- Author(s)
  Sugako Oka1, Julio Leon, Masaaki Hokama, Atsuhisa Katogi1, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  日本　神戸
- Data Source
  KAKENHI-PROJECT-25461281
[Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in a mouse model of Alzheimer’s disease
- Author(s)
  岡素雅子, 康東天, 中別府雄作
- Organizer
  変異機構研究会第27回夏の学校
- Place of Presentation
  小牧
- Year and Date
  2014-06-21 – 2014-06-22
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mechanism by which 8-oxoguanine causes dopaminergic neurodegeneration in aged mice
- Author(s)
  Zijing, Sheng, Yusaku Nakabeppu
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-dependent programed cell death induced by 8-oxoguanine accumulated in cellular DNAs and its implication in tumorigenesis and neruodegeneration
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  5th US-Japan DNA Repair Meeting
- Place of Presentation
  鳴門
- Year and Date
  2014-10-28 – 2014-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] デオキシイノシン三リン酸の蓄積はミスマッチ修復タンパク質MLH1に依存した細胞周期の遅延をもたらす
- Author(s)
  土本大介, 米嶋康臣, Nona Abolhassani, 猪山輝昭, 作見邦彦, 塩見尚子, 森雅彦, 塩見忠博, 野田哲生, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004

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98. 伊藤嘉明 (80004612)

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99. 森井成人 (80220036)

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100. 平井久丸 (90181130)

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101. 武部啓 (10028318)

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102. 伊庭英夫 (60111449)

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103. 清木元治 (10154634)

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104. 武市紀年 (40002133)

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105. 石崎寛治 (70111987)

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106. 首藤紘一 (50012612)

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107. 菊池章 (10204827)

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108. 山口政光 (00182460)

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109. 安本茂 (00112342)

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110. 佐竹正延 (50178688)

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111. 山本雅 (40134621)

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112. 秋山徹 (70150745)

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113. 登田隆 (50197894)

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114. 古市貞一 (50219094)

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115. 奥園清香 (60884450)

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116. TSUKUMA Hideaki

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117. RANCOURT Susan L.

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118. TADA Hideo

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119. Naoki Haruyama

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120. DAVID Ludlum

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121. MICHAEL Volk

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122. VOLKERT Michael

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123. LUDLUM David B.

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124. VOLKERT Mich

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125. MATIJASEVIC ゼンカ

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126. BRUCE Demple

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127. RNCOURT Derr

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128. RANCOURT Derrick E.

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129. ROBERTSON George S.

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130. SUE Rancourt

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131. RIABOWOL Kar

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132. 愿山郁

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133. HONDA hiroyuki

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134. SANEFUJI Masafumi

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137. 豊國伸哉

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138. 野田百美

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139. 矢吹悌

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140. 林良憲

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NAKABEPPU Yusaku 中別府 雄作

中別府 雄作

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Investigation of brain damage caused by reactive oxygen species and its defense mechanismsPrincipal Investigator

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Implication of oxidative damage in nucleic acids and its defense mechanisms for development of brain dysfunction which may be caused by chronic kidney diseasePrincipal Investigator

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Galectin-1による筋萎縮性側索硬化症の発症と進行の二面的制御Principal Investigator

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Regulatory mechanisms of brain function by alternative splicing products of fosB genePrincipal Investigator

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Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stressPrincipal Investigator

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NAKABEPPU Yusaku 中別府雄作

中別府雄作