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NAKABEPPU Yusaku  中別府 雄作

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中別府 雄作

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Researcher Number 30180350
Other IDs
Affiliation (based on the past Project Information) *help 1997 – 2021: Kyushu University, Medical Institute of Bioregulation Dept.of Biochemistry, Prof, 生体防御医学研究所, 教授
2014: 九州大, 学生体防御医学研究所, 教授
2010 – 2011: 九州大学, 生体防御医学研究所, 主幹教授
2010: 九州大学, 生体防御研究所, 教授
1999: 九州大学, 生医研, 教授 … More
1992 – 1996: Medical Institute of Bioregulation, Kyushu University, 生体防御医学研究所, 助手
1993: 九州大学, 医学部, 助手
1990 – 1991: Kyushu University, Faculty of Medicine Research Associate, 医学部, 助手
1986: 九州大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Risk sciences of radiation/Chemicals / Molecular biology / Neurochemistry/Neuropharmacology / Pathological medical chemistry / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Molecular biology
Except Principal Investigator
Molecular biology / Experimental pathology … More / Basic Section 52050:Embryonic medicine and pediatrics-related / Surgical dentistry / Neurology / Biological Sciences / Pediatrics / Risk sciences of radiation/Chemicals / Circulatory organs internal medicine / 環境影響評価(含放射線生物学) / Kidney internal medicine / Obstetrics and gynecology / General medical chemistry / epigenetics / Ophthalmology / Respiratory organ internal medicine / Tumor biology / Psychiatric science Less
Keywords
Principal Investigator
8-オキソグアニン / 活性酸素 / 8-oxoguanine / 酸化ストレス / ミトコンドリア / 細胞死 / 自然突然変異 / FosB / 神経変性 / MUTYH … More / OGG1 / MTH1 / CDK2 / 細胞周期 / 細胞複製 / △FosB / Jun / パーキンソン病 / アルツハイマー病 / 神経細胞死 / 酸化的DNA損傷 / ヌクレオチドプール / 転写調節 / Fos / 神経新生 / amyotrophic lateral sclerosis / Parkinson's disease / neurodegeneration / mitochondria / 2-hydroxyadenine / 筋萎縮性側索硬化症 / 2-ハイドロキシアデニン / DNA修復 / 脱アミノ化ヌクレオチド / 酸化ヌクレオチド / 病態モデル / 化学物質 / 環境ストレス / 放射線 / ミトコンドリアゲノム / 核ゲノム / 突然変異 / p53 / 8-oxo-dGTP / ΔFosB / mRNAの安定化 / サイクリンE / DNA複製 / ８－オキソグアニン / ミクログリア / ８-オキソグアニン / アミロイドーシス / 加齢 / ミクログリオーシス / 神経炎症応答 / 8-オキシグアニン / 慢性腎不全 / 認知症 / hippocampal neurogenesis / striatal medium spiny neuron / dopamine neuron / Reactive oxygen species / ハンチントン舞踏病 / 核 / 遣伝子改変マウス / 酸化ヌクレオチド損傷 / DNA酸化損傷 / 海馬神経新生 / 線条体中型有棘神経細胞 / ドパミン神経 / carcinogenesis / Reactive Oxigen Species / 遺伝子欠損マウス / 肺腫瘍 / 基質認識 / 発がん / Alzheimer's disease / reactive oxygen species / レクチン / 軸索輸送 / ニューロスフェロイド / SOD1 / 前初期遺伝子 / AP-1転写因子 / 遺伝子発現プロファイリング / 海馬硬化 / うつ病 / 側頭葉てんかん / 最初期遺伝子 / うつ / てんかん / 成体脳神経新生 / 選択的スプライシング / 転写 / 環境スレス / 細胞増殖阻害 / 酸化的損傷 / バイスタンダー効果 / RNA / DNA / P53 / (2)-ヒドロキシアデン / ミトコンドリアDNA / 核DNA / MSH2 / MLH1 / プログラム細胞死 / 発がん抑制 / 大腸腺腫症 / 家族性大腸腺腫症 / ノックアウトマウス / 修復 / ゲノム進化 / ゲノム多様性 / 組み換え / 一塩基多型 / siRNA / ピクノーシス / 酸化プリンヌクレオシド三リン酸 / ミトコンドリア機能障害 / 2-OH-dATP / がん抑制遺伝子 / アポトーシス / 核内転写因子 / 択一的翻訳開始 / 遺伝子多型 / 択一的スプライシング / 活性酵素 / hMTH1 / mutY / mutM / mutT / 酸素ラジカル / 遺伝子発現 / 神経細胞 / 細胞分化 / Rat3Y1 / cdc2 / cdk2 / AP-1 / サイクリン / CDC2 / エストロジェンレセプタ- / APー1 … More
Except Principal Investigator
酸化ストレス / DNA修復 / 自然突然変異 / 突然変異 / pyrophosphatase / 8-oxodGTP / Saccharomyces cerevisiae / 2-OH-dATP / 8-オキソグアニン / DNA repair / OGG1 / 発がん / 細胞死 / 遺伝子改変マウス / DNA複製 / アルキル化剤 / 8-oxoguanine / oxidative stress / 活性酸素 / ミューテーター / 転写調節 / サイトカイン / アポトーシス / アルツハイマー病 / p53 / DNA修復酵素 / 選択的化学療法 / オルガノイド / パーキンソン病 / DNA / apoptosis / necrosis / 酸化DNA損傷 / spontaneous mutation / orthotopic implantation / 細胞骨格 / 同所性移植 / MMP / 浸潤・転移 / Ki-67 / 8-oxo-guanine / Oxidative stress / 活性酵素 / alkylating agent / 転写因子 / cdk / Tumor suppressor gene / Mutation / メチルトランスフェラ-ゼ / DNA損傷 / ミトコンドリア / ヒストンメチル化 / PR-Set7 / 細胞周期 / ヒストンメチル化酵素 / エピジェネティクス / MTH1 / MUTYH / EGFR / インスリン抵抗性 / シグナル伝達 / 神経変性 / メチルトランスフェラーゼ / がん遺伝子c-erbB-2 / がん抑制遺伝子WT1 / △FosB / がん遺伝子EVI-1 / 軟部悪性腫瘍 / 蛍光標識PCR-SSCP法 / アルキル塩基高感度検出法 / 抗ヒトMGMT抗体 / Mer^-細胞 / O^6-アルキルグアニン / 視床・感覚路形成 / 皮質視床路 / 感覚過敏 / Shank3 / 自閉スペクトラム症 / Autism spectrum disorder / 治療モデル / てんかん性脳症 / 治療標的 / iPS / 極性 / タンパク質複合体 / SPTAN1 / 分子シグナル / 発達性てんかん性脳症 / GNAO1 / MTH1,OGG1,MUTYH / 8-oxoG / ラパマイシン / mTOR / 神経分化 / 皮質形成異常 / 海馬歯状回 / AKT-mTOR / Crh-ACTH軸 / PI3K-AKT-mTOR / 分子経路 / Pomc / Crh-POMC(ACTH) / ノックアウトマウス / 海馬 / 治療 / PI3-AKT-mTOR経路 / 自閉症 / てんかん / Pten / methyltransferase / induced mutation / gene cloning / DNA polymerase / replication fidelity / DNAポリメラーゼ / 発がんの抑制 / 遺伝子のクローニング / 遺伝情報 / アルキル科剤 / 誘導突然変異 / 遺伝子クロ-ニング / DNAポリメラ-ゼ / 複製精度 / cell death / nuclear genome / mitochondrial genome / Huntington's disease / Parkinson's disease / neurodegeneration / 損傷ヌクレオチド分解酵素 / 塩基除去修復 / 核ゲノム / ミトコンドリアゲノム / ハンチントン舞踏病 / Loss of heterozygosity(LOH) / genome instability / deamination / d1TP / pyrophosphatase活性 / 脱アミノ損傷ヌクレオチド / 酸化損傷ヌクレオチド浄化酵素 / 遺伝的不安定性 / spontaneous mutanegesis / Loss of Heterozygosity ; LOH / dITPase / 脱アミノ化 / ヌクレオチド損傷 / Loss of heterozygosity (LOH) / ゲノム不安定化 / 脱アミノ化損傷 / dITP / oral cancer / invasion・metastsis / proteomic analysis / tumor markers / 質量分析法 / 口腔癌 / プロテオーム解析 / 腫瘍マーカ / Myocyte / Cytokine / ROS / Electron transport complex / Mitochondria / Heart failure / ミトコンドア / 酸化損傷 / 心筋細胞 / 活性酸素種 / 電子伝達系 / 心不全 / pspontaneous mutation / MutT functional homologue / 2-OHdATP / 変異スペクトル / 2-oxodATP / MutTホモログ / Saccharomyces cervisiae / MutT functional homolog / MutT functionalhomoloq / cisplatin / ischemia-reperfusion injury / acute tubular necrosis / oxidative DNA damage / 虚血再潜流傷害 / ネクローシス / シスプラチン / 虚血再灌流傷害 / 急性尿細管壊死 / induced mutagenesis / mutation spectra / spontaneous tumorigenesis / oxygen radicals / 8-oxo-dGTPase / 放射線誘発突然変異 / 誘発突然変異 / 変異スペクトラム / 自然発がん / transcriptional activity / cytokine / growth factor / transcriptional factors / invasion and metastasis / squamous cell carcinoma / VEGF / 接着分子 / 浸潤転移 / 転写活性 / 増殖因子 / 扁平上皮癌 / BAX / c-fos / c-jun / Menstruation / Endometrium / Ki-17 / AP-I / FGFR / Fos / Jun / AP-1 / タモキシフェン / 子宮内膜癌 / 子宮内膜 / Carcinogenesis / Reactive oxygen / 神経細胞死 / β-オキソグアニン / 2ーOH-dATP / DNA修飾 / 8ーオキソグアニン / 癌抑制遺伝子 / O^6-methylguanine / gene targeting / repair methyltransferase / gene-defective mouse / monoclonal antibody / modified base / O^6-メチルグアニン / 遺伝子ターゲティング / 修復メチルトランスフェラーゼ / 遺伝子欠損マウス / モノクローナル抗体 / 修復塩基 / Targeting Vector / Plasmid / lambda Phage / Homologous Recombination / Gene Targeting / Targeted Mutagenesis / ネガティブ選択 / ターゲティングベクター / プラスミド / λファージ / 相同組換え / ジーンターゲティング / 標的遺伝子組換え / DNA damage / guanine / oxidation / cloning / mutation / gene / mutator / グアニン / 酸化 / クローニング / 遺伝子 / DNA Repair / DNA Replication / Oxidative Damage / 8-Oxo-dGTP / cDNA Cloning / Mutator / Spontaneous Mutation / 酸化型損傷 / 8-oxo-dGTP / cDNAクローニング / control mechanism / protein kinase / phosphorylation / cyclin / cell proliferation / cell differentiation / cell cycle / プロテインフォスファターゼ / プロテインキナーゼ / 細胞増殖制御 / 制御機構 / タンパク質キナーゼ / リン酸化 / サイクリン / 細胞増殖 / 細胞分化 / Transcriptional regulation / Growth control / Cancer cells / Tumor promoter / Tumor virus / Oncogene / Information exchange / 研究集会 / 研究室訪問 / 北米 / 研究交流 / がん研究 / 増殖制御 / がん細胞 / がん抑制遺伝子 / 発がんプロモーター / ウイルス発がん / がん遺伝子 / 研究情報交換 / Adaptive Response / Alkylating Agent / Ada Regulon / Gene Expression / Transcriptional Control / DNA Damage / DNA Repair Enzyme / DNA修復酸素 / 抗がん剤 / 突然変異の誘起 / 適応応答 / adaレギュロン / 遺伝子発現 / 肝発生 / 肝幹細胞 / 発癌 / 肝臓癌 / 癌幹細胞 / DNA酸化障害 / 糖尿病 / TFAM / 遺伝子ノックアウトマウス / set8 / ヒストンメチルトランスフェラーゼ / メチル化 / ヒストン / クロマチン / H4リジン20 / ヒストン修飾 / 染色体 / MUTHY / OGG１ / 網膜光障害 / mTOR阻害薬 / BIBW2552 / JAK1/2阻害薬 / everolimus / ｍTOR阻害薬 / 用量依存性 / gefitinib / AZD1480 / everolims / NNK / Ogg1ホモノックアウトマウス / bevacizumab / cetuximab / JAK-1/2 inhibitors / everolimus (mTOR阻害薬), / afatinib / EGFR遺伝子改変マウス / モリス水迷路 / リン酸化タウ蛋白 / 小胞体ストレス / 毒性ターン / インスリン分解酵素 / アミロイドβ / アポモルフィン / モデルマウス / 神経分子病態学 / ストレス / 癌 / がん / ゲノム / シグナル伝達と遺伝子発現 / アデノシン受容体 / c-Fos / 聴覚ミスマッチ陰性反応 / グルタミン酸 / 一酸化窒素 / ミクログリア / 分界条床核 / 扁桃体 / 双極性障害 / 精神薬理学 / 遊離ヌクレオチド損傷 / DNA酸化損傷 / 動物 / p53プロモーター / 核DNA傷害 / 神経細胞防護 / 熱ショック / 転写 / プロモーター / アミロイドβ蛋白 / 蛍光PCR-SSCP法 / 転写因子YB-1 / 平滑筋肉腫 / 尿路腫瘍 / Kid / EVI-1 / hMTH1 / APエンドヌクレアーゼ / ヒト腫瘍 / MTH1遺伝子 / ミスマッチ修復 / 遺伝子変異 / E2F4 / hMSH3 / replication error / 多型タンパク不安定性 / 遺伝子多型 / 突然変異上昇 / ミューテーター遺伝子 / Zink finger / H-ras遺伝子 / MGMT遺伝子の発現制御機構 / メチル転移酵素(MGMT) / ヒトMGMT遺伝子 / アルキル転移酵素(MGMT) / 遺伝子発現制御 / Mer^ー形質 / ヒト腫瘍細胞 / メチル転移酵素 Less

  • Research Projects

    (66 results)

  • Research Products

    (567 results)

  • Co-Researchers

    (139 People)

  •  Shank3欠損マウスと患児オルガノイドを用いた視床・感覚路発達メカニズムの解析

    • Principal Investigator
      奥園 清香
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyushu University

  •  A study for convergent molecular mechanisms underlying epileptic encephalopathy using cortical organoids

    • Principal Investigator
      Sakai Yasunari
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kyushu University

  •  Investigation of brain damage caused by reactive oxygen species and its defense mechanismsPrincipal Investigator

    • Principal Investigator
      Yusaku Nakabeppu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kyushu University

  •  Development of a new translational medicine for epilepsy using the Pten-mutant mice

    • Principal Investigator
      Sakai Yasunari
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyushu University

  •  Implication of oxidative damage in nucleic acids and its defense mechanisms for development of brain dysfunction which may be caused by chronic kidney diseasePrincipal Investigator

    • Principal Investigator
      Nakabeppu Yusaku
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyushu University

  •  Function of histone methyltransferase PR-set7 and its relationship to carcinogenesis

    • Principal Investigator
      Oda Hisanobu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      National Hospital Organization, Kyushu Cancer Center

  •  Molecular mechanism of degeneration of dopaminergic neurons caused by 8-oxoguanine

    • Principal Investigator
      Sheng Zijing
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kyushu University

  •  Galectin-1による筋萎縮性側索硬化症の発症と進行の二面的制御Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  hTFAM improves impaired insulin signaling in Alzheimer's disease

    • Principal Investigator
      OKA SUGAKO
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University

  •  Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse

    • Principal Investigator
      KIURA Katsuyuki
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Okayama University

  •  Study of Pathological Mechanism in Light Induced Retinal Damage using DNA Base Excision Repair Gene Knockout Mice

    • Principal Investigator
      OHIRA Akihiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Shimane University

  •  Analysis of chromatin function mediated by histone H4 lysine 20 methylation

    • Principal Investigator
      ODA Hisanobu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      epigenetics
    • Research Institution
      National Hospital Organization, Kyushu Cancer Center

  •  Regulatory mechanisms of brain function by alternative splicing products of fosB genePrincipal Investigator

    • Principal Investigator
      NAKABEPPU Yusaku
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Molecular biology
    • Research Institution
      Kyushu University

  •  Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stressPrincipal Investigator

    • Principal Investigator
      NAKABEPPU YUSAKU
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Kyushu University

  •  環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Kyushu University

  •  Regulation of MUTYH expression by p53 plays a critical role in cell death

    • Principal Investigator
      OKA Sugako
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Kyushu University

  •  Development of apomorphine therapy for Alzheimer disease

    • Principal Investigator
      OHYAGI Yasumasa
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University

  •  Genomic damage and cancer cell death caused by reactive oxygen speciesPrincipal Investigator

    • Principal Investigator
      NAKABEPPU Yusaku
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  Molecular and phathobiological analysis of defects in quality control systems for DNA and free nucleotides by using mouse models

    • Principal Investigator
      TSUCHIMOTO Daisuke
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Kyushu University

  •  Disorder of reward circuit in bipolar disorders : integration of basic and clinical investigation

    • Principal Investigator
      KANBA Shigenobu
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Kyushu University

  •  酸化的ストレスによる細胞死と消化管がん抑制機構におけるMUTYHの働きPrincipal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  Roles of the defense mechanisms against oxidative damage in nucleic acids for maintenance of brain cellsPrincipal Investigator

    • Principal Investigator
      NAKABEPPU Yusaku
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kyushu University

  •  酸化的ストレスによる細胞死と消化管がん抑制機構におけるMUTYHの働きPrincipal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  ゲノム多型及び遺伝病の成因としての自然DNA酸化損傷とその修復機構の破綻Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  Molecular pathological analysis of defects in DNA base excision repair system using gene modified mice

    • Principal Investigator
      TSUCHIMOTO Daisuke
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Kyushu University

  •  ヒト癌におけるMTH1発現亢進の意義の解明とMTH1の発現・機能抑制法の開発Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  The sanitizing systems for endogenous nucleotide lesions, and their roles on spontaneous mutagenesis

    • Principal Investigator
      NUNOSHIBA Tatsuo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Tohoku University

  •  Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure

    • Principal Investigator
      TSUTSUI Hiroyuki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      HOKKAIDO UNIVERSITY
      Kyushu University

  •  Establishment of detectional system of individual tumor markers

    • Principal Investigator
      MORIFUJI Masayo, 大石 正道
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      KYUSHU UNIVERSITY

  •  Study on oxidative DNA damage and repair enzyme in acute and chronic renal disease

    • Principal Investigator
      HIRAKATA Hideki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Kyushu University

  •  Implication of oxidized nucleotides in spontaneous mutation and their sanitizing systems

    • Principal Investigator
      NUNOSHIBA Tatsuoi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Tohoku University

  •  Oxidative DNA damage-induced tumorigenesis and its avoidance mechanism

    • Principal Investigator
      TSUZUKI Teruhisa
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  アルツハイマー病の細胞内Aβ42誘導性ニューロンアポトーシス死の分子メカニズム

    • Principal Investigator
      OHYAGI Yasumasa
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University

  •  Analysis of the regulated mechanisms of cell proliferation and apoptosis in the endometrium at AP-1 binding site

    • Principal Investigator
      HACHISUGA Toru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Fukuoka University

  •  The total analyses of the mechanism of the invasion and metastasis in human oral squamus cell carcinoma by the transcriptional factors

    • Principal Investigator
      MORIFUJI Masayo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      KYUSHU UNIVERSITY

  •  Study of Defense Mechanisms against Cellular Damage Caused by Free RadicalsPrincipal Investigator

    • Principal Investigator
      NAKABEPPU Yusaku
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      KYUSHU UNIVERSITY

  •  プロトオンコジーンfosBによる細胞増殖と細胞死の制御機構の解析Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University

  •  活性酸素による神経細胞死とその防御機構の解析Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University

  •  Oxygen-induced DNA damage and its repair mechamism

    • Principal Investigator
      TSUZUKI Teruhisa
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Molecular biology
    • Research Institution
      KYUSHU UNIVERSITY

  •  DNA Repair Mechanisms Protecting Brain and Neuronal Cells from Damage Caused by Reactive Oxygen SpeciesPrincipal Investigator

    • Principal Investigator
      NAKABEPPU Yusaku
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      KYUSHU UNIVERSITY

  •  ヒト発がんにおける複製・修復遺伝子の変異

    • Principal Investigator
      石川 隆俊
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo

  •  ヒトMTH1蛋白質の発現制御と突然変異抑制機能の解析Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  活性酸素による神経細胞死とその防止機構の解析Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  Repair of alkylation DNA damage

    • Principal Investigator
      SEKIGUCHI Mutsuo
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Molecular biology
    • Research Institution
      Fukuoka Dental College

  •  転写制御遺伝子群の発癌への関与

    • Principal Investigator
      林 健志
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  哺乳動物における酸素ラジカルによる自然突然変異とその抑制機構Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  Development of an Effecient System for Gene Targeting

    • Principal Investigator
      TSUZUKI Teruhisa
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Molecular biology
    • Research Institution
      Kyushu University

  •  転写制御遺伝子群の発癌への関与

    • Principal Investigator
      林 健志
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  Active Oxygen-induced DNA Damage and its Repair Mechanisms

    • Principal Investigator
      SEKIGUCHI Mutsuo
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      KYUSHU UNIVERSITY

  •  ΔFosBによる細胞複製の制御Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  転写制御遺伝子群の発癌への関与

    • Principal Investigator
      林 健志
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  fosB遺伝子による細胞のがん化と遺伝子発現制御Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  Oxygen-induced DNA Damage and its Repair Mechanisms

    • Principal Investigator
      SEKIGUCHI Mutsuo
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      KYUSHU UNIVERSITY

  •  △FosBによる細胞の癌化と遺伝子発現Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyushu University

  •  Fos,Junによる細胞複製の制御Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  FosBおよび△FosBによる細胞分化の制御Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Molecular biology
    • Research Institution
      Kyushu University

  •  Molecular Mechanisms of Differentiation and Proliferation Switches

    • Principal Investigator
      KATSURA Isao, 登田 隆
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Institute of Genetics
      Kyoto University

  •  Fos,Junの標的遺伝子の検索Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyushu University

  •  Fos,Junによる細胞複製の制御Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  O^6ーアルキルグアニンーアルキル転移酵素の制がんと発がんにおける役割

    • Principal Investigator
      池永 満生
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University

  •  Jun/Fos複合体(APー1)による細胞複製の制御Principal Investigator

    • Principal Investigator
      中別府 雄作
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

  •  O^6-アルキルグアニン-アルキル転移酵素の制がんと発がんにおける役割

    • Principal Investigator
      池永 満生
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University

  •  O^6-アルキルグアニン-アルキル転移酵素の制がんと発がんにおける役割

    • Principal Investigator
      池永 満生
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University

  •  Information Exchange on Cancer Research with North American Countries.

    • Principal Investigator
      YAMAGUCHI Nobuo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Institute of Medical Science, University of Tokyo

  •  Molecular mechanisms of the adaptive response to alkylating agents

    • Principal Investigator
      SEKIGUCHI Mutsuo
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      KYUSHU UNIVERSITY

  •  Maintenance of Genetic Information and Mutagenesis Mechanisms

    • Principal Investigator
      SEKIGUCHI Mutsuo
    • Project Period (FY)
      1986 – 1990
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      Kyushu University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

  • [Book] Diabetes Mellitus: A risk factor for Alzheimer's Disease2019
    • Author(s)
      Nakabeppu Y and Ninomiya T. (Editors)
    • Total Pages
      248
    • Publisher
      Springer Singapore
    • ISBN
      9789811335396
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Book] Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases. in The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design2017
    • Author(s)
      Y Nakabeppu
    • Total Pages
      34
    • Publisher
      World Scientific Publishing Co., Pte. Ltd. Singapore
    • Data Source
      KAKENHI-PROJECT-15K15085

  • [Book] 酸化ストレスの医学 改訂第2版2014
    • Author(s)
      中別府 雄作
    • Total Pages
      456
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Book] 遺伝子変異の機構2014
    • Author(s)
      中別府雄作
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Book] Ganglion Cells: Morphology, Functional Development and Role in Disease2014
    • Author(s)
      Sango K, Niimi N, Tsukamoto M, Utsunomiya K, Sakumi K, Nakabeppu Y, Kadoya T, Horie H
    • Total Pages
      158
    • Publisher
      Nova Science Publishers, Inc.
    • Data Source
      KAKENHI-PUBLICLY-25110724

  • [Book] 図説 分子病態学 ５版2014
    • Author(s)
      中別府 雄作
    • Total Pages
      408
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Book] Ganglion Cells: Morphology, Functional Development and Role in Disease2014
    • Author(s)
      Sango K, Niimi N, Tsukamoto M, Utsunomiya K, Sakumi K, Nakabeppu Y, Kadoya T, Horie H
    • Total Pages
      158
    • Publisher
      Nova Science Publishers, Inc
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Book] Ganglion Cells: Morphology, Functional Development and Role in Disease2014
    • Author(s)
      Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T., and Horie, H.
    • Total Pages
      139
    • Publisher
      Nova Science Publishers, Inc.
    • Data Source
      KAKENHI-PUBLICLY-25110724

  • [Book] Ganglion Cells: Morphology, Functional Development and Role in Disease2014
    • Author(s)
      Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T., and Horie, H.
    • Total Pages
      139
    • Publisher
      Nova Science Publishers, Inc.
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Book] Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage2009
    • Author(s)
      Oka, S., Ohno, M., Nakabeppu, Y.
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Book] in mitochondrial DNA by immunofluorescence method. Methods Mol Biol2009
    • Author(s)
      Ohno, M., Oka, S., Nakabeppu, Y.
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Book] 遺伝子変異の機構 図説 分子病態学 4版(一瀬白帝, 鈴木宏治 編集)2008
    • Author(s)
      中別府雄作
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-18013038

  • [Book] 遺伝子変異の機構図説分子病態学4版(一瀬白帝, 鈴木宏治編集)2008
    • Author(s)
      中別府 雄作
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Book] Prvention of the mutagenecity and cytotoxicity of oxidized pruine nucleotides. In Evands, M.D. and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids.2007
    • Author(s)
      Nakabeppu, Y., et. al.
    • Publisher
      Springer, Austin, TX
    • Data Source
      KAKENHI-PROJECT-18013038

  • [Book] DNA Replication and Transcription:In Meyrers RA(eds), Genomics and Genetics:From Molecular Details to Analysis and Techniques.2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Publisher
      Wiley-VCH Verlag GmbH and Co.,Weinheim,Germany
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Book] DNA Replication and Transcription. (From Molecular Details to Analysis and Techniques)(In : Meyers RA, editor. Genomics and Genetics)2007
    • Author(s)
      Nakabeppu Y, Maki H, Sekiguchi. M
    • Total Pages
      27
    • Publisher
      Wiley-VCH Verlag GmbH ＆ Co., Weinheim, Germany
    • Data Source
      KAKENHI-PROJECT-18013038

  • [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, In Oxidative Damage to Nucleic Acids2007
    • Author(s)
      Nakabeppu, Y., Behmanesh, M., Yamaguchi, H., Yoshimura, D., Sakumi, K
    • Total Pages
      14
    • Publisher
      Landes Bioscience/Eurekah, Georgetown, TX. USA
    • Data Source
      KAKENHI-PROJECT-18013038

  • [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides.In Evans, M.D.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids.2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Publisher
      Springer,Austin,TX
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides.In Evans, MD.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Publisher
      Springer,Austin,TX
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Book] DNA Replication and Transcription:In Meyrers RA(eds), Genomics and Genetics:From Molecular Details to Analysis and Techniques.2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Publisher
      Wiley-VCH Verlag GmbH and Co., Weinheim, Germany
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, In Oxidative Damage to Nucleic Acids2007
    • Author(s)
      Nakabeppu, Y., Behmanesh, M., Yamaguchi, H., Yoshimura, D., Sakumi, K
    • Total Pages
      14
    • Publisher
      Landes Bioscience/Eurekah, Georgetown, TX USA
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nuckeotides,In Oxidative Damage to Nucleic Acids.2007
    • Author(s)
      Nakabeppu, Y., Behmanesh, M., Yamaguchi, H., Yoshimura, D., Sakumi, K.
    • Total Pages
      14
    • Publisher
      Georgetown,TX. : Landes Bioscience/Eurekah
    • Data Source
      KAKENHI-PROJECT-16390119

  • [Book] DNA Replication and Transcription: In Meyrers RA(eds), Genomics and Genetics: From Molecular Details to Analysis and Techniques2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Publisher
      Wiley-VCH Verlag GmbH and Co.,Weinheim,Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Book] DNA Replication and Transcription: In Meyrers RA(eds), Genomics and Genetics: From Molecular Details to Analysis and Techniques.2007
    • Author(s)
      Nakabeppu, Y., et. al.
    • Publisher
      Wiley-VCH Verlag GmbH and Co., Weinheim, Germany
    • Data Source
      KAKENHI-PROJECT-18013038

  • [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides. In Evans, M.D.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids.2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Publisher
      Springer,Austin,TX
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, in Oxidative Damage to Nucleic Acids.2007
    • Author(s)
      Nakabeppu, Y. et al.
    • Publisher
      Georgetown, TX. : Landes Bioscience / Eurekah (in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model2020
    • Author(s)
      Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Lloyd, R. S., and Sampath, H.
    • Journal Title

      PLoS One

      Volume: 15 Issue: 1 Pages: e0227501-e0227501

    • DOI

      10.1371/journal.pone.0227501

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in Ogg1-/- mice2020
    • Author(s)
      Kvandova, M., Filippou, K., Steven, S., Oelze, M., Kalinovic, S., Stamm, P., Frenis, K., Vujacic-Mirski, K., Sakumi, K., Nakabeppu, Y., Bagheri Hosseinabadi, M., Dovinova, I., Epe, B., Munzel, T., Kroller-Schon, S. and Daiber, A.
    • Journal Title

      Free Radical Research

      Volume: in press Issue: 4 Pages: 280-292

    • DOI

      10.1080/10715762.2020.1754410

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice2020
    • Author(s)
      Funahashi Satomi、Okazaki Yasumasa、Akatsuka Shinya、Takahashi Takashi、Sakumi Kunihiko、Nakabeppu Yusaku、Toyokuni Shinya
    • Journal Title

      Free Radical Research

      Volume: N/A Issue: 2-3 Pages: 1-231

    • DOI

      10.1080/10715762.2020.1743285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05462, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-20K07588, KAKENHI-PROJECT-16H02468, KAKENHI-PUBLICLY-20H05502

  • [Journal Article] Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer's Disease Brain2019
    • Author(s)
      Nakabeppu, Y.
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 1128 Pages: 27-44

    • DOI

      10.1007/978-981-13-3540-2_3

    • ISBN
      9789811335396, 9789811335402
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Origins of Brain Insulin and Its Function2019
    • Author(s)
      Nakabeppu, Y.
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 1128 Pages: 1-11

    • DOI

      10.1007/978-981-13-3540-2_1

    • ISBN
      9789811335396, 9789811335402
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice2019
    • Author(s)
      Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y., and Wang, Y.
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 143 Pages: 482-493

    • DOI

      10.1016/j.freeradbiomed.2019.09.005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes2019
    • Author(s)
      Haruyama, N., Sakumi, K., Katogi, A., Tsuchimoto, D., De Luca, G., Bignami, M., and Nakabeppu, Y.
    • Journal Title

      Progress in Neurobiology

      Volume: 180 Pages: 101613-101613

    • DOI

      10.1016/j.pneurobio.2019.04.002

    • NAID

      120006839234

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis2018
    • Author(s)
      Hommyo Reiji、Suzuki Satoshi O.、Abolhassani Nona、Hamasaki Hideomi、Shijo Masahiro、Maeda Norihisa、Honda Hiroyuki、Nakabeppu Yusaku、Iwaki Toru
    • Journal Title

      Neuropathology

      Volume: － Issue: 3 Pages: 247-259

    • DOI

      10.1111/neup.12466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-17J01738, KAKENHI-PROJECT-26290017

  • [Journal Article] 活性酸素による核酸の酸化と老化関連疾患－発がんから神経変性まで－2018
    • Author(s)
      2.中別府雄作
    • Journal Title

      実験医学

      Volume: 36 Pages: 161-170

    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.2018
    • Author(s)
      Izumi H, Shinoda Y, Saito T, Saido TC, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K.
    • Journal Title

      Neuroscience.

      Volume: 377 Pages: 87-97

    • DOI

      10.1016/j.neuroscience.2018.02.031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15456, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-16J02855, KAKENHI-PROJECT-16K20909, KAKENHI-PROJECT-16H05219

  • [Journal Article] A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.2018
    • Author(s)
      Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI.
    • Journal Title

      Annals of Neurology

      Volume: 84 Issue: 2 Pages: 208-224

    • DOI

      10.1002/ana.25279

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11477, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-17K19663, KAKENHI-PROJECT-17H01391

  • [Journal Article] Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation2017
    • Author(s)
      Kajitani Kosuke、Yanagimoto Kazuyuki、Nakabeppu Yusaku
    • Journal Title

      Psychopharmacology

      Volume: 234 Issue: 19 Pages: 2919-2927

    • DOI

      10.1007/s00213-017-4683-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.2017
    • Author(s)
      Li GH, Akatsuka S, Chew SH, Jiang L, Nishiyama T, Sakamoto A, Takahashi T, Futakuchi M, Suzuki H, Sakumi K, Nakabeppu Y, Toyokuni S.
    • Journal Title

      Pathol Int.

      Volume: 67 Issue: 11 Pages: 564-574

    • DOI

      10.1111/pin.12598

    • NAID

      120006382249

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19913, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-15K06837, KAKENHI-PROJECT-16H02468

  • [Journal Article] Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi2017
    • Author(s)
      Shijo Masahiro、Honda Hiroyuki、Suzuki Satoshi O.、Hamasaki Hideomi、Hokama Masaaki、Abolhassani Nona、Nakabeppu Yusaku、Ninomiya Toshiharu、Kitazono Takanari、Iwaki Toru
    • Journal Title

      Brain Pathology

      Volume: 28 Issue: 1 Pages: 58-71

    • DOI

      10.1111/bpa.12475

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26290017, KAKENHI-PROJECT-17H01391

  • [Journal Article] 2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway2017
    • Author(s)
      Asada Shinji、Ohta Eiko、Akimoto Yoriko、Abolhassani Nona、Tsuchimoto Daisuke、Nakabeppu Yusaku
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 6528-6528

    • DOI

      10.1038/s41598-017-06636-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] 8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle2017
    • Author(s)
      Vartanian Vladimir、Tumova Jana、Dobrzyn Pawel、Dobrzyn Agnieszka、Nakabeppu Yusaku、Lloyd R. Stephen、Sampath Harini
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 7 Pages: e0181687-e0181687

    • DOI

      10.1371/journal.pone.0181687

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice.2017
    • Author(s)
      Yoshii Y, Inoue T, Sato T, Iwasaki Y, Kojima M, Yada T, Nakabeppu Y, Noda M.
    • Journal Title

      Neurochem Res

      Volume: 42(9) Issue: 9 Pages: 2658-2665

    • DOI

      10.1007/s11064-017-2281-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08276, KAKENHI-PROJECT-17H01391

  • [Journal Article] Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes2017
    • Author(s)
      Seifermann Marco、Ulges Alexander、Bopp Tobias、Melcea Svetlana、Sch?fer Andrea、Oka Sugako、Nakabeppu Yusaku、Klungland Arne、Niehrs Christof、Epe Bernd
    • Journal Title

      DNA Repair

      Volume: 58 Pages: 13-20

    • DOI

      10.1016/j.dnarep.2017.08.005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain.2017
    • Author(s)
      Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y.
    • Journal Title

      Mech Ageing Dev.

      Volume: 161 Pages: 95-104

    • DOI

      10.1016/j.mad.2016.05.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26290017, KAKENHI-PROJECT-26460490, KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-17H01391

  • [Journal Article] Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation2017
    • Author(s)
      Castillo Erika、Leon Julio、Mazzei Guianfranco、Abolhassani Nona、Haruyama Naoki、Saito Takashi、Saido Takaomi、Hokama Masaaki、Iwaki Toru、Ohara Tomoyuki、Ninomiya Toshiharu、Kiyohara Yutaka、Sakumi Kunihiko、LaFerla Frank M.、Nakabeppu Yusaku
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 17762-17762

    • DOI

      10.1038/s41598-017-17999-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290017, KAKENHI-PROJECT-17H01391

  • [Journal Article] Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer2017
    • Author(s)
      Fujishita Takatoshi、Okamoto Tatsuro、Akamine Takaki、Takamori Shinkichi、Takada Kazuki、Katsura Masakazu、Toyokawa Goji、Shoji Fumihiro、Shimokawa Mototsugu、Oda Yoshinao、Nakabeppu Yusaku、Maehara Yoshihiko
    • Journal Title

      Lung Cancer

      Volume: 109 Pages: 52-57

    • DOI

      10.1016/j.lungcan.2017.04.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse2017
    • Author(s)
      Chikama Koji、Yamada Hidetaka、Tsukamoto Tatsuo、Kajitani Kosuke、Nakabeppu Yusaku、Uchimura Naohisa
    • Journal Title

      Brain Research

      Volume: 1676 Pages: 77-82

    • DOI

      10.1016/j.brainres.2017.09.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Journal Article] Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice.2016
    • Author(s)
      Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.
    • Journal Title

      Sci Rep

      Volume: 未 Issue: 1 Pages: 22991-22991

    • DOI

      10.1038/srep22991

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09655, KAKENHI-PROJECT-24240120, KAKENHI-PROJECT-26893189, KAKENHI-PROJECT-15K09624, KAKENHI-PROJECT-16K08626, KAKENHI-PROJECT-26640081

  • [Journal Article] Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.2016
    • Author(s)
      S. Oka, J. Leon, K. Sakumi, T. Ide, D. Kang, F.M. LaFerla, and Y. Nakabeppu
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 37889-37889

    • DOI

      10.1038/srep37889

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-15K15085

  • [Journal Article] 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions2016
    • Author(s)
      Julio, Leon, Sakumi Kunihiko, Castillo Erika, Sheng Zijing, Oka Sugako, Nakabeppu Yusaku.
    • Journal Title

      Scientific Reports

      Volume: 25 Issue: 1 Pages: 22086-22086

    • DOI

      10.1038/srep22086

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460490, KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-25461281

  • [Journal Article] MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?2016
    • Author(s)
      Y. Nakabeppu, E. Ohta, N. Abolhassani
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 印刷中 Pages: 151-158

    • DOI

      10.1016/j.freeradbiomed.2016.11.002

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-17H01391

  • [Journal Article] ゲノムに蓄積した8-oxoguanine に起因する病態とその防御機構 －発がんから神経変性まで－2016
    • Author(s)
      中別府 雄作
    • Journal Title

      基礎老化研究

      Volume: 40 Pages: 23-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K15085

  • [Journal Article] アルツハイマー病におけるインスリン産生低下とミトコンドリア機能不全2015
    • Author(s)
      中別府雄作
    • Journal Title

      細胞工学

      Volume: 34 Pages: 389-391

    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] アルツハイマー病は脳の糖尿病!?2015
    • Author(s)
      中別府雄作
    • Journal Title

      NHKきょうの健康

      Volume: 325 Pages: 94-97

    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.2015
    • Author(s)
      Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T
    • Journal Title

      J Pharmacol Sci

      Volume: 127 Issue: 4 Pages: 446-455

    • DOI

      10.1016/j.jphs.2015.03.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-26340025, KAKENHI-PUBLICLY-15H00897, KAKENHI-PLANNED-24108009, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-25460334

  • [Journal Article] 脳内酸化ストレス2014
    • Author(s)
      中別府雄作
    • Journal Title

      分子精神医学

      Volume: 14 Pages: 200-201

    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] 8-oxoguanine causes spontaneous de novo germline mutations in mice.2014
    • Author(s)
      Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., and Nakabeppu, Y.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 4689-4689

    • DOI

      10.1038/srep04689

    • NAID

      120005703609

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PLANNED-24108009, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-25241016

  • [Journal Article] Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation2014
    • Author(s)
      Stavnezer J, Linehan EK, Thompson MR, Habboub G, Ucher AJ, Kadungure T, Tsuchimoto D, Nakabeppu Y
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 111 Issue: 25 Pages: 9217-9222

    • DOI

      10.1073/pnas.1405590111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Characterization of galectin-1-positive cells in the mouse hippocampus.2014
    • Author(s)
      Kajitani, K., Kobayakawa, Y., Nomaru, H., Kadoya, T., Horie, H., and Nakabeppu, Y.
    • Journal Title

      Neuroreport

      Volume: 25 Issue: 3 Pages: 171-176

    • DOI

      10.1097/wnr.0000000000000068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PUBLICLY-25110724, KAKENHI-PROJECT-25870494

  • [Journal Article] Altered expression of diabetes-related genes in Alzheimer's disease brains: the hisayama study2014
    • Author(s)
      Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y
    • Journal Title

      Cereb Cortex

      Volume: 24 Issue: 9 Pages: 2476-2488

    • DOI

      10.1093/cercor/bht101

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24591720, KAKENHI-PROJECT-25461281

  • [Journal Article] International Symposium on "Germline Mutagenesis and Biodiversification"2014
    • Author(s)
      Uchimura A, Hara Y, Gondo Y, Nakabeppu Y
    • Journal Title

      Genes Genet Syst

      Volume: 89 Pages: 93-95

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells2014
    • Author(s)
      Nakabeppu Y
    • Journal Title

      Int J Mol Sci

      Volume: 15 Issue: 7 Pages: 12543-12557

    • DOI

      10.3390/ijms150712543

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage.2014
    • Author(s)
      Jalland, C.M., Benestad, S.L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjoras, M., and Tranulis, M.A.
    • Journal Title

      Free Radic Biol Med

      Volume: 68 Pages: 1-7

    • DOI

      10.1016/j.freeradbiomed.2013.11.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Galectin-1 deficiency improves axonal swelling of motor neurons in SOD1 transgenic mice.2014
    • Author(s)
      Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J.I., and Nakabeppu, Y.
    • Journal Title

      Neuropathol Appl Neurobiol

      Volume: N/A Issue: 2 Pages: 227-244

    • DOI

      10.1111/nan.12123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PUBLICLY-25110724, KAKENHI-PROJECT-25293204, KAKENHI-PROJECT-25870494

  • [Journal Article] Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia.2014
    • Author(s)
      Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y.N., Kajitani, K., Tsuchimoto, D., Nestler, E.J., and Nakabeppu, Y.
    • Journal Title

      Glia

      Volume: N/A Issue: 8 Pages: 1284-1298

    • DOI

      10.1002/glia.22680

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24591735, KAKENHI-PROJECT-25870494

  • [Journal Article] Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes.2014
    • Author(s)
      Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K., and Kitazono, T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 34 Issue: 1 Pages: 44-51

    • DOI

      10.1161/atvbaha.113.302214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23591195

  • [Journal Article] Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice2014
    • Author(s)
      Isoda T, Nakatsu Y, Yamauchi K, Piao J, Yao T, Honda H, Nakabeppu Y, Tsuzuki T
    • Journal Title

      Int J Biol Sci

      Volume: 10 Issue: 8 Pages: 940-947

    • DOI

      10.7150/ijbs.9241

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-26340025

  • [Journal Article] Inhibitory effects of dietary Spirulina platensis on UVB induced skin inflammatory responses and carcinogenesis.2014
    • Author(s)
      Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y., and Nishigori, C.
    • Journal Title

      J Invest Dermatol

      Volume: N/A Issue: 10 Pages: 2610-2619

    • DOI

      10.1038/jid.2014.188

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25461281, KAKENHI-PROJECT-25461668

  • [Journal Article] Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells2014
    • Author(s)
      Guikema JE, Linehan EK, Esa N, Tsuchimoto D, Nakabeppu Y, Woodland RT, Schrader CE
    • Journal Title

      J Immunol

      Volume: 193 Pages: 931-939

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death2014
    • Author(s)
      Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y
    • Journal Title

      Oncogenesis

      Volume: 3 Issue: 10 Pages: 1-10

    • DOI

      10.1038/oncsis.2014.35

    • NAID

      120005703608

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25461281

  • [Journal Article] DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3beta and expressions of cyclin D1 and TCF7L2 in cancer model mice.2014
    • Author(s)
      Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., and Sasaguri, T.
    • Journal Title

      Biochem Pharmacol

      Volume: N/A Issue: 3 Pages: 340-348

    • DOI

      10.1016/j.bcp.2014.03.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-26340025

  • [Journal Article] Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains.2014
    • Author(s)
      Hamasaki, H., Honda, H., Suzuki, S.O., Hokama, M., Kiyohara, Y., Nakabeppu, Y., and Iwaki, T.
    • Journal Title

      Neuropathology

      Volume: N/A Issue: 3 Pages: 284-290

    • DOI

      10.1111/neup.12095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24650186, KAKENHI-PROJECT-25430050, KAKENHI-PROJECT-26290017

  • [Journal Article] GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons.2013
    • Author(s)
      Takaku S, Yanagisawa H, Watabe K, Horie H, Kadoya T, Sakumi K, Nakabeppu Y, Poirier F, Sango K.
    • Journal Title

      Neurochem Int

      Volume: 62 Issue: 3 Pages: 330-339

    • DOI

      10.1016/j.neuint.2013.01.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22500324, KAKENHI-PROJECT-24500428, KAKENHI-PROJECT-25430056

  • [Journal Article] Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.2013
    • Author(s)
      Matsumoto, A., Yamafuji, M., Tachibana, T., Nakabeppu, Y., Noda, M., and Nakaya, H.
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 3273-3273

    • DOI

      10.1038/srep03273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24659111

  • [Journal Article] Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus.2013
    • Author(s)
      Sakai, Y., Ohkubo, K., Matsushita, Y., Akamine, S., Ishizaki, Y., Torisu, H., Ihara, K., Sanefuji, M., Kim, M.S., Lee, K.U., Shaw, C.A., Lim, J., Nakabeppu, Y., and Hara, T.
    • Journal Title

      Eur J Med Genet

      Volume: 59 Issue: 9 Pages: 475-783

    • DOI

      10.1016/j.ejmg.2013.06.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23591503, KAKENHI-PROJECT-24650199

  • [Journal Article] fosB-Null Mice Display Impaired Adult Hlppocampal Neurogenesis and Spontaneous Epilepsy2013
    • Author(s)
      Yutsudo, N, et. al.
    • Journal Title

      Neuropsychopharmacology

      Volume: 38 Issue: 5 Pages: 895-906

    • DOI

      10.1038/npp.2012.260

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23500498, KAKENHI-PROJECT-23657116, KAKENHI-PROJECT-24591299, KAKENHI-PROJECT-24591735

  • [Journal Article] Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice.2013
    • Author(s)
      suji, H., Ishii-Ohba, H., Shiomi, T., Shiomi, N., Katsube, T., Mori, M., Nenoi, M., Ohno, M., Yoshimura, D., Oka, S., Nakabeppu, Y., Tatsumi, K., Muto, M., and Sado, T.
    • Journal Title

      J Radiat Res

      Volume: 54 Issue: 3 Pages: 453-466

    • DOI

      10.1093/jrr/rrs128

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Altered expression of diabetes-related genes in Alzheimer’s disease brains: The Hisayama study2013
    • Author(s)
      Hokama, M., S. Oka, J. Leon, T. Ninomiya, H. Honda, K. Sasaki, T. Iwaki, T. Ohara, T. Sasaki, F.M. LaFerla, Y. Kiyohara, and Y. Nakabeppu.
    • Journal Title

      Cereb Cortex

      Volume: 23

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] 核酸の酸化損傷に起因する神経変性の分子機序2013
    • Author(s)
      中別府雄作
    • Journal Title

      医学のあゆみ

      Volume: 24 Pages: 961-968

    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus.2013
    • Author(s)
      Koga Y, Inazato M, Nakamura T, Hashikawa C, Chirifu M, Michi A, Yamashita T, Toma S, Kuniyasu A, Ikemizu S, Nakabeppu Y, Yamagata Y.
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun

      Volume: 69(Pt 1) Issue: 1 Pages: 45-48

    • DOI

      10.1107/s1744309112048002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23390027, KAKENHI-PROJECT-23659025, KAKENHI-PROJECT-23790052, KAKENHI-PROJECT-25440031, KAKENHI-PLANNED-22131007, KAKENHI-PUBLICLY-23121523, KAKENHI-PUBLICLY-24113719

  • [Journal Article] Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes.2012
    • Author(s)
      Fujita K, Yamafuji M, Nakabeppu Y, Noda M.
    • Journal Title

      Oxid Med Cell Longev

      Volume: 2012 Pages: 324256-324256

    • DOI

      10.1155/2012/324256

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22590084

  • [Journal Article] Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype.2012
    • Author(s)
      Yogianti F, Kunisada M, Ono R, Sakumi K, Nakabeppu Y, Nishigori C.
    • Journal Title

      Mutagenesis

      Volume: 26 Issue: 6 Pages: 637-643

    • DOI

      10.1093/mutage/ges029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.2012
    • Author(s)
      Sheng, Z., et. al.
    • Journal Title

      The Journal of clinical investigation

      Volume: 122 Issue: 12 Pages: 4344-4361

    • DOI

      10.1172/jci65053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004

  • [Journal Article] MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration.2012
    • Author(s)
      Murakami Y, Ikeda Y, Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T.
    • Journal Title

      Am J Pathol

      Volume: 181 Issue: 4 Pages: 1378-1386

    • DOI

      10.1016/j.ajpath.2012.06.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24249083

  • [Journal Article] 8-Oxoguanine causes neurodegeneration during Mutyh-mediated DNA base excision repair2012
    • Author(s)
      Sheng Z, Oka S, Tsuchimoto D, Abolhassani N, Nomaru H, Sakumi K, Yamada H, Nakabeppu Y
    • Journal Title

      J Clin Invest

      Volume: 12 Pages: 4344-4361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Journal Article] 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction.2012
    • Author(s)
      Sampath H, Vartanian V, Rollins MR, Sakumi K, Nakabeppu Y, Lloyd RS.
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 12 Pages: e51697-e51697

    • DOI

      10.1371/journal.pone.0051697

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration2012
    • Author(s)
      Murakami Y, Ikeda Y, Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T
    • Journal Title

      Am J Pathol

      Volume: 181(4) Pages: 1378-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Journal Article] ニトロソ化ストレスによるイノシン三リン酸の生成と細胞応答2011
    • Author(s)
      作見邦彦, 土本大介, 中別府雄作
    • Journal Title

      細胞工学

      Volume: 31 Pages: 175-180

    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice2011
    • Author(s)
      Tsuzuki T, Piao JS, Isoda T, Sakumi K, Nakabeppu Y, Nakatsu Y
    • Journal Title

      Health Phys

      Volume: 100 Pages: 293-294

    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] A Role for SNX1 in the Regulation of EGF-Dependent Phosphorylated EGFR Endocytosis Via the Early/Late Endocytic Pathway in a Gefitinib-Sensitive Human Lung Cancer Cells2011
    • Author(s)
      Nishimura Y, Yoshioka K, Takiguchi S, Bereczky B, Nakabeppu Y, Itoh K
    • Journal Title

      Curr.Signal Transduct.Ther.

      Volume: 6 Issue: 3 Pages: 383-395

    • DOI

      10.2174/157436211797484047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Cancer-Related PRUNE2 Protein Is Associated with Nucleotides and Is Highly Expressed in Mature Nerve Tissues.2011
    • Author(s)
      Iwama, E., D.Tsuchimoto, T.Iyama, K.Sakumi, A.Nakagawara, K.Takayama, Y.Nakanishi, Y.Nakabeppu.
    • Journal Title

      J Mol Neurosci.

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Nucleotides function as endogenous chemical sensors for oxidative stess signaling.2011
    • Author(s)
      Ihara, H., T.Sawa, Y.Nakabeppu, T.Akaike.
    • Journal Title

      J Clin Biochem Nutr

      Volume: 48 Pages: 33-39

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] FosB Is Essential for the Enhancement of Stress Tolerance and Antagonizes Locomotor Sensitization by ΔFosB2011
    • Author(s)
      Ohnishi YN, et.al.
    • Journal Title

      Biological Psychiatry

      Volume: 70-5 Issue: 5 Pages: 487-495

    • DOI

      10.1016/j.biopsych.2011.04.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23657116

  • [Journal Article] Apurinic/Apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.2011
    • Author(s)
      Guikema, J.E., R.M.Gerstein, E.K.Linehan, E.K.Cloherty, E.Evan-Browning, D.Tsuchimoto, Y.Nakabeppu, C.E.Schrader.
    • Journal Title

      J Immunol

      Volume: 186 Pages: 1943-1950

    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Therapeutic effects of hydrogen in animal models of Parkinson's disease2011
    • Author(s)
      Fujita, et al
    • Journal Title

      Parkinson's disease

      Volume: 176 Pages: 307875-307875

    • DOI

      10.4061/2011/307875

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J03325, KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22590084

  • [Journal Article] A DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis.2011
    • Author(s)
      Oka, S., Y.Nakabeppu.
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 677-682

    • NAID

      10029291748

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis2011
    • Author(s)
      Oka S, Nakabeppu Y
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 4 Pages: 677-682

    • DOI

      10.1111/j.1349-7006.2011.01869.x

    • NAID

      10029291748

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22501014

  • [Journal Article] Increased expression of versican in the inflammatory response to UVB-and reactive oxygen species-induced skin tumorigenesis2011
    • Author(s)
      Kunisada M, Yogianti F, Sakumi K, Ono R, Nakabeppu Y, Nishigori C
    • Journal Title

      Am J Pathol

      Volume: 176 Issue: 6 Pages: 3056-3065

    • DOI

      10.1016/j.ajpath.2011.08.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer.2010
    • Author(s)
      Goto, M., K.Shinmura, Y.Nakabeppu, H.Tao, H.Yamada, T.Tsuneyoshi, H.Sugimura.
    • Journal Title

      Hum Mutat

      Volume: 31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1.2010
    • Author(s)
      Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E, Lord Cj, Ashworth A.
    • Journal Title

      Cancer Cell 17

      Pages: 235-248

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] NUDT16 is a (deoxy) inosine diphosphatase, and its deficiency induces accumulation of single strand breaks in nuclear DNA and growth arrest2010
    • Author(s)
      Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y.
    • Journal Title

      Nucleic Acids Research (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.2010
    • Author(s)
      Nakabeppu Y, Oka S, Sheng Z, Tsuchimoto D, Sakumi K
    • Journal Title

      Mutation Res. inpress

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals2010
    • Author(s)
      Abolhassani N, Iyama T, Tsuchimoto D(共同責任著者), Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y(共同責任著者)
    • Journal Title

      Nucleic Acids Res. 15

    • NAID

      120005227421

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.2010
    • Author(s)
      Nakabeppu, Y., S.Oka, Z.Sheng, D.Tsuchimoto, K.Sakumi.
    • Journal Title

      Mutat Res

      Volume: 703 Pages: 51-58

    • NAID

      120005227112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] A comprehensive screening system for damaged nucleotide-binding proteins.2010
    • Author(s)
      Tsuchimoto, D., T.Iyama, M.Nonaka, N.Abolhassani, E.Ohta, K.Sakumi, Y.Nakabeppu.
    • Journal Title

      Mutat Res

      Volume: 703 Pages: 37-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single strand breaks in nuclear DNA with growth arrest2010
    • Author(s)
      Iyama T, Abolhassani N, Tsuchimoto D (責任著者), Nonaka M, Nakabeppu Y
    • Journal Title

      Nucleic Acids Res. 12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells.2010
    • Author(s)
      Sakumi, K., N.Abolhassani, M.Behmanesh, T.Iyama, D.Tsuchimoto, Y.Nakabeppu.
    • Journal Title

      Mutat Res

      Volume: 703 Pages: 43-50

    • NAID

      120005227205

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] NUDT16 is a (deoxy) inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2010
    • Author(s)
      Iyama, T., N.Abolhassani, D.Tsuchimoto, M.Nonaka, Y.Nakabeppu.
    • Journal Title

      Nucleic Acids Res

      Volume: 38 Pages: 4834-4843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dIDP/IDP from nucleotide pools in mammals.2010
    • Author(s)
      Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y.
    • Journal Title

      Nucleic Acids Research (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1.2010
    • Author(s)
      Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E, Lord CJ, Ashworth A
    • Journal Title

      Cancer Cell 17

      Pages: 235-248

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
    • Author(s)
      Abolhassani, N., T.Iyama, D.Tsuchimoto, K.Sakumi, M.Ohno, M.Behmanesh, Y.Nakabeppu.
    • Journal Title

      Nucleic Acids Res

      Volume: 38 Pages: 2891-2903

    • NAID

      120005227421

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
    • Author(s)
      Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y.
    • Journal Title

      Nucleic Acids Res.

      Volume: 38 Pages: 2891-2903

    • NAID

      120005227421

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241013

  • [Journal Article] Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis.2009
    • Author(s)
      Gushima M, Hirahashi M, Matsumoto T, Fujita K, Fujisawa R, Mizumoto K, Nakabeppu Y, Iida M, Yao T, Tsuneyoshi M
    • Journal Title

      J Pathol 219

      Pages: 77-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase2009
    • Author(s)
      Nonaka M, Tsuchimoto D(責任著者), Sakumi K, Nakabeppu Y
    • Journal Title

      preferring 5-iodocytosine. FEBS J. 276(6)

      Pages: 1654-66

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] Altered expression of MUTYH and an increase in 8-hydroxy-deoxyguanosine are early events in ulcerative colitis-associated carcinogenesis.2009
    • Author(s)
      Gushima M, Hirahashi M, Matsumoto T, Fujita K, Fujisawa R, Mizumoto K, Nakabeppu Y, Iida M, Yao T, Tsuneyoshi M
    • Journal Title

      Journal of Pathology 219

      Pages: 77-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] 塩基除去修復酵素MUTYHに依存したプログラム細胞死と発癌抑制機構2009
    • Author(s)
      中別府雄作
    • Journal Title

      実験医学 27巻

      Pages: 135-139

    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] ITPase-deficient mice show growth retardation and die before weaning.2009
    • Author(s)
      Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y.
    • Journal Title

      Cell Death and Differentiation 16

      Pages: 1315-1322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] ミトコンドリアのデオキシリボヌクレオチドプールの酸化と細胞死2009
    • Author(s)
      中別府雄作
    • Journal Title

      医学のあゆみ 232巻

      Pages: 681-689

    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.2009
    • Author(s)
      Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.
    • Journal Title

      International Immunology 21

      Pages: 947-955

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage2009
    • Author(s)
      Oka S, Ohno M, Nakabeppu Y.
    • Journal Title

      Methods in Molecular Biology 554

      Pages: 251-264

    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method.2009
    • Author(s)
      Ohno M, Oka S, Nakabeppu Y.
    • Journal Title

      Methods in Molecular Biology 554

      Pages: 199-212

    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methy1-4-pheny1-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.2009
    • Author(s)
      Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M.
    • Journal Title

      PLoS One 30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.2009
    • Author(s)
      Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.
    • Journal Title

      Int Immunol. 8

      Pages: 947-55

    • NAID

      10025387710

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] ITPase-deficient mice show growth retardation and die before weaning2009
    • Author(s)
      Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y(責任著者)
    • Journal Title

      Cell Death Differ. 10

      Pages: 1315-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] AIF2009
    • Author(s)
      中別府雄作
    • Journal Title

      Medical Tribune 42巻

      Pages: 46-46

    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.2008
    • Author(s)
      Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y
    • Journal Title

      DNA Repair 7

      Pages: 418-430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines.2008
    • Author(s)
      Yamamoto S, Tanaka K, Sakimura R, Okada T, Nakamura T, Li Y, Takasaki M, Nakabeppu Y, Iwamoto Y
    • Journal Title

      Anticancer Res 28

      Pages: 1585-1591

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.2008
    • Author(s)
      Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y
    • Journal Title

      EMBO J 27

      Pages: 421-432

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus.2008
    • Author(s)
      Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, Kanda T, Sakumi K, Nakabeppu Y
    • Journal Title

      DNA Repair 7

      Pages: 1437-1454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.2008
    • Author(s)
      De Luca G, Russo MT, Degan P, Tiveron C, Zijno A, Meccia E, Ventura I, Mattei E, Nakabeppu Y, Crescenzi M, Pepponi R, Pezzola A, Popoli P, Bignami M.
    • Journal Title

      PLoS Genet. 4(11)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] 核およびミトコンドリアDNAの酸化損傷によって引き起こされる2つの独立した細胞死の経路2008
    • Author(s)
      岡素雅子, 中別府雄作
    • Journal Title

      実験医学 26巻

      Pages: 1376-1379

    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus.2008
    • Author(s)
      Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, Kanda T, Sakumi K, Nakabeppu Y(責任著者)
    • Journal Title

      DNA Repair (Amst). 7(9)

      Pages: 1437-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.2008
    • Author(s)
      Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y(責任著者).
    • Journal Title

      EMBO J. 27(2)

      Pages: 421-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.2008
    • Author(s)
      Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y(責任著者)
    • Journal Title

      DNA Repair (Amst). 7(3)

      Pages: 418-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis.2008
    • Author(s)
      Yanaru-Fujisawa R, Matsumoto T, Ushijima, Y, Esaki M, Hirahashi M, Gushima M, Yao T, Nakabeppu Y, Iida M
    • Journal Title

      Clin Genet 73

      Pages: 545-553

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] A Role for Oxidized DNA Precursors in Huntington's Disease-Like Striatal Neurodegeneration.2008
    • Author(s)
      De Luca G, Russo MT, Degan P, Tiveron C, Zijno A, Meccia E, Ventura I, Mattei E, Nakabeppu Y, Crescenzi M, Pepponi R, Pezzola A, Popoli P, Bignami M
    • Journal Title

      PLoS Genet 4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.2008
    • Author(s)
      Nakane H, Hirota S, Brooks PJ, Nakabeppu Y, Nakatsu, Y, Nishimune Y, Iino A, Tanaka K
    • Journal Title

      DNA Repair 7

      Pages: 1938-1950

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease2007
    • Author(s)
      Nakabeppu, Y, et. al.
    • Journal Title

      J Neurosci Res 85(5)

      Pages: 919-934

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis.2007
    • Author(s)
      Sakamoto K, Tominaga Y, Yamauchi K, Nakatsu Y, Sakumi K, Yoshiyama K, Egashira A, Kura S, Yao T, Tsuneyoshi M, Maki H, Nakabeppu Y(共同責任著者), Tsuzuki T.
    • Journal Title

      Cancer Res. 67(14)

      Pages: 6599-604

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.2007
    • Author(s)
      Miyata, K., Yasukawa, T., Fukuda, M., Takeuchi, T., Yamazaki, K., Sakumi, K., Tamamori-Adachi, M., Ohnishi, Y., Ohtsuki, Y., Nakabeppu, Y., Kitajima, S., Onishi, S., Aso, T.
    • Journal Title

      Cell Death Differ. 14・4

      Pages: 716-726

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Accumulation of 8-oxo-deoxyguanosine in Cardiovascular Tissues with the Development of Hypertension.2007
    • Author(s)
      Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M., Nakabeppu, Y.
    • Journal Title

      DNA Repair (印刷中)

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis.2007
    • Author(s)
      Tsuzuki, T., Nakatsu, Y., Nakabeppu, Y.
    • Journal Title

      Cancer Sci (印刷中)

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer.2007
    • Author(s)
      Kunisada M, Kumimoto H, Ishizaki K, Sakumi K, Nakabeppu Y, Nishigori C.
    • Journal Title

      J Invest Dermatol. 127(12)

      Pages: 2865-71

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination.2007
    • Author(s)
      Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, Stavnezer J, Schrader CE.
    • Journal Title

      J Exp Med. 204(12)

      Pages: 3017-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] Oxidative damage in nucleic acids and Parkinson's disease.2007
    • Author(s)
      Nakabeppu Y., et. al.
    • Journal Title

      J Neurosci Res. 85(5)

      Pages: 919-934

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Journal Article] Oxidative damage in nucleic acids and Parkinson's disease2007
    • Author(s)
      Nakabeppu Y., et. al.
    • Journal Title

      J.Neurosci.Res 85

      Pages: 919-934

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Oxidative damage in nucleic acids and Parkinson's disease.2007
    • Author(s)
      Nakabeppu Y., et. al.
    • Journal Title

      J Neurosci Res. 85(5)

      Pages: 919-934

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Accumulation of 8-oxo-deoxyguanosine in Cardiovascular Tissues with the Development of Hypertension.2007
    • Author(s)
      Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M., Nakabeppu,Y.
    • Journal Title

      DNA Repair (印刷中)

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Oxidative damage in nucleic acids and Pakinson's disease.2007
    • Author(s)
      Nakabeppu, Y, et. al.
    • Journal Title

      J Neurosci Res. 85(5)

      Pages: 919-934

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] RNA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.2007
    • Author(s)
      Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Seah, J., Kwei, M., Ikegami, T., Handa, H., Nakabeppu, Y., Tanaka,K
    • Journal Title

      DNA Repair (印刷中)

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.2007
    • Author(s)
      Miyata, K., Yasukawa, T., Fukuda, M., Takeuchi, T., Yamazaki, K., Sakumi, K., Tamamori-Adachi, M., Ohnishi, Y., Ohtsuki, Y., Nakabeppu, Y., Kitajima, S., Onishi, S., Aso, T.
    • Journal Title

      Cell Death Differ. 14・4

      Pages: 716-726

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, in Oxidative Damage to Nucleic Acids.2007
    • Author(s)
      Nakabeppu, Y. et al.
    • Journal Title

      Georgetown, TX. : Landes Bioscience/Eurekah (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis.2007
    • Author(s)
      Tsuzuki, T., Nakatsu, Y., Nakabeppu, Y.
    • Journal Title

      Cancer Sci (印刷中)

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Oxidative Damage in Nucleit Acids and Parkinson's Disease.2007
    • Author(s)
      Nakabeppu, Y., Tsuchimoto, D., Yamaguchi, H., Sakumi, K.
    • Journal Title

      J. Neurosci, Res. 85・5

      Pages: 919-934

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis.2007
    • Author(s)
      Tsuzuki, T., Nakatsu, Y., Nakabeppu, Y.
    • Journal Title

      Cancer Sci. (印刷中)

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease.2007
    • Author(s)
      Nakabeppu, Y., Tsuchimoto, D., Yamaguchi, H., Sakumi, K.
    • Journal Title

      J.Neurosci.Res. 85・5

      Pages: 919-934

    • NAID

      120000985083

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] RNA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor FTIIS.2007
    • Author(s)
      Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Seah, J., Kwei, M., Ikegami, T., Handa, H., Nakabeppu, Y., Tanaka, K
    • Journal Title

      DNA Repair (印刷中)

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease.2007
    • Author(s)
      Nakabeppu, Y. et al.
    • Journal Title

      J. Neurosci. Res. 85(5)

      Pages: 919-934

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease.2007
    • Author(s)
      Nakabeppu, Y. et al.
    • Journal Title

      J.Neurosci.Res. 85(5)

      Pages: 919-934

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Accumulation of 8-oxo-deoxyguanosine in Cardiovascular Tissues with the Development of Hypertension.2007
    • Author(s)
      Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M., Nakabeppu, Y.
    • Journal Title

      DNA Repair (印刷中)

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] RNA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.2007
    • Author(s)
      Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Seah, J., Kwei, M., Ikegami, T., Handa, H., Nakabeppu, Y., Tanaka, K
    • Journal Title

      DNA Repair (印刷中)

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
    • Author(s)
      Nakabeppu, Y., et. al.
    • Journal Title

      Biol Chem 387(4)

      Pages: 373-379

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] 酸化ストレスとミトコンドリア2006
    • Author(s)
      中別府 雄作, 他
    • Journal Title

      Clinical Neuroscience 21

      Pages: 79-83

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Mutagenesis and Carcinogenesis Caused by the Oxidation of Nucleic Acids.2006
    • Author(s)
      Y.Nakabeppu, et al.
    • Journal Title

      Biological Chemistry 387(in press)

    • Data Source
      KAKENHI-PROJECT-17014070

  • [Journal Article] MTH1, an oxidized purine nucleoside triphospghatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydrophridine.2006
    • Author(s)
      Yamaguchi, H., Kajitani, K., Dan, Y., Furuichi, M., Ohno, M., Sakumi, K., Kang, D., Nakabeppu.Y.
    • Journal Title

      Cell Death Differ. 13・4

      Pages: 551-563

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
    • Author(s)
      Nakabeppu, Y. et al.
    • Journal Title

      Biol.Chem. 387(4)

      Pages: 373-379

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease.2006
    • Author(s)
      Arai, T., Fukae, J., Hatano, T., Kubo, S., Ohtsubo, T., Nakabeppu, Y., Mori, H., Mizuno, Y., Hattori, N.
    • Journal Title

      Acta Neuropathol. 112・2

      Pages: 139-145

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Angiotensin I-converting enzyme gene polyorphism modifies the smoking-cancer association : the Hisayama Study.2006
    • Author(s)
      Arima, H., Kiyohara, Y., Tanizaki, Y., Nakabeppu, Y., Kubo, M., Kato, I., Sueishi, K., Tsuneyoshi, M., Fujishima, M., Iida, M.
    • Journal Title

      Eur. J. Cancer Prev. 15・3

      Pages: 196-201

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Recognition of Nucleotide Analogs containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein.2006
    • Author(s)
      Kamiya, H., Cadena-Amaro, C., Dugue, L., Yakushiji, H., Minakawa, N., Matsuda, A., Pochet, S., Nakabeppu, Y., Harashima, H.
    • Journal Title

      J. Biochem. 140・6

      Pages: 843-849

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
    • Author(s)
      Nakabeppu, Y. et al.
    • Journal Title

      Biol. Chem. 387(4)

      Pages: 373-379

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.2006
    • Author(s)
      Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., Nakabeppu, Y.
    • Journal Title

      Genome Res. 16・5

      Pages: 567-575

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
    • Author(s)
      Nakabeppu, Y., Sakumi, K., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T., Nakatsu, Y.
    • Journal Title

      Biol. Chem. 387・4

      Pages: 373-379

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Reactive oxigen species and regulation of biological function2006
    • Author(s)
      Nakabeppu, Y
    • Journal Title

      BIO Clinina 21(12)

      Pages: 79-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
    • Author(s)
      Nakabeppu, Y., et. al.
    • Journal Title

      DNA Repair 5(7)

      Pages: 761-772

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.2006
    • Author(s)
      Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H., Poirier, F., Griffioen, A.W.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A. 103・43

      Pages: 15975-15980

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
    • Author(s)
      Nakabeppu, Y., Kajitani, K., Sakamoto, K., Yamaguchi, H., Tsuchimoto, D.
    • Journal Title

      DNA Repair 5・7

      Pages: 761-772

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides.2006
    • Author(s)
      Y.Nakabeppu et al.
    • Journal Title

      Oxidative Damage to Nucleic Acids (On line)

    • Data Source
      KAKENHI-PROJECT-17014070

  • [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
    • Author(s)
      Nakabeppu, Y., Kajitani, K., Sakamoto, K., Yamaguchi, H., Tsuchimoto, D.
    • Journal Title

      DNA Repair 5・7

      Pages: 761-772

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.2006
    • Author(s)
      Yamaguchi, H., Kajitani, K., Dan, Y., Furuichi, M., Ohno, M., Sakumi, K., Kang, D., Nakabeppu, Y.
    • Journal Title

      Cell Death Differ. 13・4

      Pages: 551-563

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.2006
    • Author(s)
      Sakai, Y., Oda, H., Yoshimura, D., Furuichi, M., Kang, D., Iwai, S., Hara, T., Nakabeppu, Y.
    • Journal Title

      J. Mol. Med. 84・8

      Pages: 660-670

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
    • Author(s)
      Nakabeppu, Y. et al.
    • Journal Title

      DNA Repair 5(7)

      Pages: 761-772

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Neonatal Ventral Hippocampal Lesions Produce an Elevation of ΔFosB-like Protein(s) In the Rodent Neocortex.2006
    • Author(s)
      Powell, K.J., Binder, T.L., Hori, S., Nakabeppu, Y., R., D., Weinberger, Lipska, B.K., Robertson, G.S.
    • Journal Title

      Neuropsychopharmacology 31・4

      Pages: 700-711

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.2006
    • Author(s)
      Akatsuka, S., Aung, T.T., Dutta, K.K., Jiang, L., Lee, W.H., Liu, Y.T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., Naito, Y., Yoshikawa, T., Kasai, H., Tominaga, Y., Sakumi, K., Nakabeppu, Y., Kawai, Y., Uchida, K., Yamasaki, A., Tsuruyama, T., Yamada, Y., Toyokuni, S.
    • Journal Title

      Am. J. Pathol. 169・4

      Pages: 1328-1342

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein.2006
    • Author(s)
      Kamiya, H., Cadena-Amaro, C., Dugue, L., Yakushiji, H., Minakawa, N., Matsuda, A., Pochet, S., Nakabeppu, Y., Harashima,H.
    • Journal Title

      J.Biochem. 140・6

      Pages: 843-849

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Neurodgenerative diseases and oxidative stress2006
    • Author(s)
      Nakabeppu., Y., et. al.
    • Journal Title

      Bunnshi Saibou Chiryou 5(6)

      Pages: 35-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.2006
    • Author(s)
      Akatsuka, S., Aung, T.T., Dutta, K.K., Jiang, L, Lee, W.H., Liu, Y.T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., Naito, Y., Yoshikawa, T., Kasai, H., Tominaga, Y., Sakumi, K., Nakabeppu, Y., Kawai, Y., Uchida, K., Yamasaki, A., Tsuruyama, T., Yamada,Y., Toyokuni,S.
    • Journal Title

      Am.J.Pathol. 169・4

      Pages: 1328-1342

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease.2006
    • Author(s)
      Arai, T., Fukae, J., Hatano, T., Kubo, S., Ohtsubo, T., Nakabeppu, Y., Mori, H., Mizuno, Y., Hattori, N.
    • Journal Title

      Acta Neuropathol. 112・2

      Pages: 139-145

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.2006
    • Author(s)
      Nakamura, T., Kitaguchi, Y., Miyazawa, M., Kamiya, H., Toma, S., Ikemizu, S., Shirakawa, M., Nakabeppu, Y, Yamagata, Y.
    • Journal Title

      Acta Crystallograph.Sect.F.Struct.Biol.Cryst.Commun. 62・12

      Pages: 1283-1285

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein.2006
    • Author(s)
      Kamiya, H., Cadena-Amaro, C., Dugue, L., Yakushiji, H., Minakawa, N., Matsuda, A., Pochet, S., Nakabeppu, Y., Harashima, H.
    • Journal Title

      J. Biochem. 140・6

      Pages: 843-849

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides2006
    • Author(s)
      Y.Nakabeppu et al.
    • Journal Title

      DNA Repair (in press)

    • Data Source
      KAKENHI-PROJECT-17014070

  • [Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.2006
    • Author(s)
      Akatsuka, S., Aung, T.T., Dutta, K.K., Jinag.L., Lee, W.H., Liu, Y.T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., Naito, Y., Yoshikawa, T., Kasai, H., Tominaga, Y., Sakumi, K., Nakabeppu, Y., Kawai, Y., Uchida, K., Yamasaki, A., Tsuruyama, T., Yamada, Y., Toyokuni, S.
    • Journal Title

      Am. J. Pathol. 169・4

      Pages: 1328-1342

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an altemative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.2006
    • Author(s)
      Sakai, Y., Oda, H., Yoshimura, D., Furuichi, M., Kang, D., Iwai, S., Hara, T., Nakabeppu,Y.
    • Journal Title

      J.Mol.Med. 84・8

      Pages: 660-670

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] 活性酸素と生命機能の制御2006
    • Author(s)
      中別府 雄作, 他
    • Journal Title

      BIO Clinica 5

      Pages: 35-43

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.2006
    • Author(s)
      Yamaguchi, H., Kajitani, K., Dan, Y., Furuichi, M., Ohno, M., Sakumi, K., Kang, D., Nakabeppu,Y.
    • Journal Title

      Cell Death Differ. 13・4

      Pages: 551-563

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.2006
    • Author(s)
      Nakamura, T., Kitaguchi, Y., Miyazawa, M., Kamiya, H., Toma, S., Ikemizu, S., Shirakawa, M., Nakabeppu, Y., Yamagata, Y.
    • Journal Title

      Acta Crystallograph, Sect. F. Struct. Biol. Cryst. Commun. 62・12

      Pages: 1283-1285

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.2006
    • Author(s)
      Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., Nakabeppu,Y.
    • Journal Title

      Genome Res. 16・5

      Pages: 567-575

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice.2006
    • Author(s)
      Arima, T., Yamasaki, K., John.R.M., Kato, K., Sakumi, K., Nakabeppu, Y., Wake, N., Kono, T.
    • Journal Title

      Genomics 88・5

      Pages: 650-658

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease.2006
    • Author(s)
      Arai, T., Fukae, J., Hatano, T., Kubo, S., Ohtsubo, T., Nakabeppu, Y., Mori, H., Mizuno, Y, Hattori,N.
    • Journal Title

      Acta Neuropathol. 112・2

      Pages: 139-145

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Oxidative stress and mirochondria2006
    • Author(s)
      Nakabeppu, Y
    • Journal Title

      Clinical Neuroscience 24(6)

      Pages: 639-642

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice.2006
    • Author(s)
      Arima, T., Yamasaki, K., John, R.M., Kato, K., Sakumi, K., Nakabeppu, Y., Wake, N., Kono, T.
    • Journal Title

      Genomics 88・5

      Pages: 650-658

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
    • Author(s)
      Nakabeppu, Y., Sakumi, K., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T., Nakatsu,Y.
    • Journal Title

      Biol.Chem. 387・4

      Pages: 373-379

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids2006
    • Author(s)
      Nakabeppu Y., et. al.
    • Journal Title

      Biol Chem 387

      Pages: 373-379

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] MTH1,an oxidized purine nucleoside triphosphatase,prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides2006
    • Author(s)
      Nakabeppu Y., et. al.
    • Journal Title

      DNA Repair 5

      Pages: 761-772

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] 活性酸素によるゲノムの酸化とヒトゲノムの多様性2006
    • Author(s)
      中別府 雄作, 他
    • Journal Title

      実験医学 24

      Pages: 756-1753

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.2006
    • Author(s)
      Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., Nakabeppu, Y.
    • Journal Title

      Genome Res. 16・5

      Pages: 567-575

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Oxidation of genome by reactive oxygen species and diversity of human genome2006
    • Author(s)
      Nakabeppu, Y., et. al.
    • Journal Title

      Jikken Igaku 24(1)

      Pages: 756-1753

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] MTH1,an oxidized purine nucleoside triphosphatase,prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
    • Author(s)
      Nakabeppu, Y., Kajitani, K., Sakamoto, K., Yamaguchi, H., Tsuchimoto,D.
    • Journal Title

      DNA Repair 5・7

      Pages: 761-772

    • Data Source
      KAKENHI-PROJECT-16390119

  • [Journal Article] Neonatal Ventral Hippocampal Lesions Produce an Elevation of ΔFosB-like Protein(s) In the Rodent Neocortex.2006
    • Author(s)
      Powell, K.J., Binder, T.L., Hori, S., Nakabeppu, Y., R., D., Weinberger, Lipska, B.K., Robertson, G.S.
    • Journal Title

      Neuropsychopharmacology 31・4

      Pages: 700-711

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] 脳神経変性疾患と酸化ストレス2006
    • Author(s)
      中別府 雄作, 他
    • Journal Title

      分子細胞治療 5

      Pages: 35-43

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.2006
    • Author(s)
      Thijssen, V.L., Postel, r。, Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum.L G., Bakkers, J., Mayo, K H., Poirier, F., Brifficen, A.W.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A. 103・43

      Pages: 15975-15980

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an altemative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.2006
    • Author(s)
      Sakai, Y., Oda, H., Yoshimura, D., Furuichi, M., Kang, D., Iwai, S., Hara, T., Nakabeppu, Y.
    • Journal Title

      J. Mol. Med. 84・8

      Pages: 660-670

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association : the Hisayama Study.2006
    • Author(s)
      Arima, H., Kiyohara, Y., Tanizaki, Y., Nakabeppu, Y., Kubo, M., Kato, I., Sueishi, K., Tsuneyoshi, M., Fujishima, M., Iida, M.
    • Journal Title

      Eur. J. Cancer Prev. 15・3

      Pages: 196-201

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.2006
    • Author(s)
      Nakamura, T., Kitaguchi, Y., Miyazawa, M., Kamiya, H., Toma, S., Ikemizu, S., Shirakawa, M., Nakabeppu, Y., Yamagata, Y.
    • Journal Title

      Acta Crystallograph. Sect. F. Struct. Biol. Cryst. Commun. 62・12

      Pages: 1283-1285

    • Data Source
      KAKENHI-PROJECT-18013038

  • [Journal Article] Mutagenesis and carcinogenesis carsed by the oxidation of nucleic acids.2006
    • Author(s)
      Nakabeppu, Y., Sakumi, K., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T., Nakatsu, Y.
    • Journal Title

      Biol. Chem. 387・4

      Pages: 373-379

    • Data Source
      KAKENHI-PROJECT-18300124

  • [Journal Article] A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA.2005
    • Author(s)
      Ushijima Y, Tominaga Y, Miura T, Tsuchimoto D, Sakumi K, Nakabeppu Y.
    • Journal Title

      Nucleic Acids Research 33・2

      Pages: 672-682

    • Data Source
      KAKENHI-PROJECT-16012248

  • [Journal Article] A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA2005
    • Author(s)
      Ushijima Y, Tominaga Y, Miura T, Tsuchimoto D, Sakumi K, Nakabeppu Y
    • Journal Title

      Nucleic Acids Res. 33

      Pages: 672-682

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510041

  • [Journal Article] Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs2004
    • Author(s)
      Kamiya H, Yakushiji H, Dugue L, Tanimoto M, Pochet S, Nakabeppu Y, Harashima H
    • Journal Title

      J Mol Biol. 336

      Pages: 843-850

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510041

  • [Journal Article] A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae2004
    • Author(s)
      Nunoshiba T, Ishida R, Sasaki M, Iwai S, Nakabeppu Y, Yamamoto K
    • Journal Title

      Nucleic Acids Res. 32

      Pages: 5339-5348

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510041

  • [Journal Article] Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice.2004
    • Author(s)
      Ide Y, Tsuchimoto D, Tominaga Y, Nakashima M, Watanabe T, Sakumi K, Ohno M, Nakabeppu Y.
    • Journal Title

      Blood 104・13

      Pages: 4097-4103

    • Data Source
      KAKENHI-PROJECT-16012248

  • [Journal Article] A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c(PCD1 gene) in Saccharomyces cerevisiae.2004
    • Author(s)
      Nunoshiba T, Ishida R, Sasaki M, Iwai S, Nakabeppu Y, Yamamoto K.
    • Journal Title

      Nucleic Acids Research 32・18

      Pages: 5339-5348

    • Data Source
      KAKENHI-PROJECT-16012248

  • [Journal Article] The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death2004
    • Author(s)
      Nakabeppu Y, Tsuchimoto D, Furuichi M, Sakumi K
    • Journal Title

      Free Radical Res. 38

      Pages: 423-429

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510041

  • [Journal Article] The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death2004
    • Author(s)
      Nakabeppu Y
    • Journal Title

      Free Radical Res 38

      Pages: 423-429

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15510041

  • [Journal Article] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates.2004
    • Author(s)
      Mishima M, Sakai Y, Itoh N, Kamiya H, Furuichi M, Takahashi M, Yamagata Y, Iwai S, Nakabeppu Y, Shirakawa M.
    • Journal Title

      Journal of Biological Chemistry 279・32

      Pages: 33806-33815

    • Data Source
      KAKENHI-PROJECT-16012248

  • [Journal Article] The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death.2004
    • Author(s)
      Nakabeppu Y, Tsuchimoto D, Furuichi M, Sakumi K.
    • Journal Title

      Free Radical Research 38・5

      Pages: 423-429

    • Data Source
      KAKENHI-PROJECT-16012248

  • [Journal Article] A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients2004
    • Author(s)
      Kimura Y, Oda S, Egashira A, Kakeji Y, Baba H, Nakabeppu Y, Maehara Y.
    • Journal Title

      Journal of Medical Genetics 41・5

    • Data Source
      KAKENHI-PROJECT-16012248

  • [Journal Article] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates2004
    • Author(s)
      Mishima M, Sakai Y, Itoh N, Kamiya H, Furuichi M, Takahashi M, Yamagata Y, Iwai S, Nakabeppu Y, Shirakawa M
    • Journal Title

      J Biol Chem. 279

      Pages: 33806-33815

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510041

  • [Journal Article] Futile short-patch DNA base excision repair of adenine : 8-oxoguanine mispair.2004
    • Author(s)
      Hashimoto K, Tominaga Y, Nakabeppu Y, Moriya M.
    • Journal Title

      Nucleic Acids Research 32・19

      Pages: 5928-5934

    • Data Source
      KAKENHI-PROJECT-16012248

  • [Journal Article] Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption2003
    • Author(s)
      Sakumi K, Tominaga Y, Furuichi M, Xu P, Tsuzuki T, Sekiguchi M, Nakabeppu Y.
    • Journal Title

      Cancer Res. 63

      Pages: 902-905

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510041

  • [Journal Article] An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress2003
    • Author(s)
      Yoshimura D, Sakumi K, Ohno M, Sakai Y, Furuichi M, Iwai S, Nakabeppu Y
    • Journal Title

      J Biol Chem. 278

      Pages: 37965-37973

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510041

  • [Journal Article] DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1
    • Author(s)
      Sarah A. Martin, Nuala McCabe, Michelle Mullarkey, Robert Cummins, Darren J. Burgess, Y Nakabeppu, S Oka, Elaine Kay, Christopher J. Lord and Alan Ashworth
    • Journal Title

      Cancer Cell

      Volume: 17 Pages: 235-245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] Shank3a regulates the susceptibility to seizure and thalamocortical connectivity2021
    • Author(s)
      Sayaka Okuzono, Yuki Matsushita, Yasunari Sakai*, Ryoji Taira, Kousuke Yonemoto, Satoshi Akamine, Yoshitomo Motomura, Masafumi Sanefuji, Yusaku Nakabeppu, Shouichi Ohga
    • Organizer
      American Epilepsy Society Annual Meeting 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07865

  • [Presentation] 塩基修復酵素，OGG1とMUTYHの欠損はAppNL-G-Fノックイン・アルツハイマー病モデルマウスにおけるミクログリアの活性化状態と脳内のアミロイドβの沈着および行動様式を変化させる2019
    • Author(s)
      水野 裕理，Abolhassani Nona，Mazzei Guianfranco，斉藤 貴志，西道 隆臣，中別府 雄作
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] High-fat diet exacerbates neuropathology in AppNL-F/NL-F mouse model of Alzheimer’s disease2019
    • Author(s)
      Guianfranco Mazzei, Nona Abolhassani, Ryohei Ikegami, Naoki Haruyama, Takashi Saito, Takaomi C. Saido, Yusaku Nakabeppu
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Disturbed glutamate signaling in AD hippocampus revealed by an integrated analysis of altered expression profiles of genes in both human and mouse brains with Alzheimer's disease pathology2019
    • Author(s)
      Nona Abolhassani, Masaaki Hokama, Daisuke Saitou, Masahiro Shijo, Takashi Saito, Takaomi C. Saido, Mikita Suyama, Toru Iwaki, Yutaka Kiyohara, Yusaku Nakabeppu
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Defense mechanisms against the dysfunction resulting from damage to the genome by reactive oxygen species during aging2019
    • Author(s)
      Naoki Haruyama, Nona Abolhassani, Guianfranco Mazzei, Julio Leon, Zijing Sheng, Sugako Oka, Mizuki Ohno, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      The 2019 International Association of Gerontology and Geriatrics (IAGG) Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] マウスにおける神経幹細胞特異的ITPA欠損は神経細胞の脱分極を引き起こし，てんかん性発作と早期死亡の原因となる2019
    • Author(s)
      土本 大介，古賀 祐一郎，林 良憲，アボルハッサニ ノナ，米嶋 康臣，作見 邦彦，中西 博，豊國 伸哉，中別府 雄作
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Altered gene expression profiles in Alzheimer’s disease model mice caused by deficiency in three genes counteracting the buildup of 8-oxoguanine in DNA2019
    • Author(s)
      Nona Abolhassani, Yuri Mizuno, Guianfranco Mazzei, Takashi Saito, Takaomi C. Saido, Yusaku Nakabeppu
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] 加齢雌マウス脳に蓄積する8-オキソグアニンは海馬歯状回と大カレハ島の神経新生を障害し性的二形性をきたす2019
    • Author(s)
      春山 直樹，作見 邦彦，加藤木 敦央，土本 大介，中別府 雄作
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in dentate gyrus and major island of Calleja, and thus causing sexually dimorphic phenotypes2019
    • Author(s)
      Yusaku Nakabeppu, Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Gabriele De Luca, Margherita Bignami
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Alzheimer's disease brain exhibits feature of brain diabetes with impaired insulin signaling, mitochondrial dysfunction and oxidative stress2019
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      Korean Society for Biochemistry and Molecular Biology International Conference 2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] 活性酸素によるゲノム損傷に起因する機能障害とその防御機構の解明2018
    • Author(s)
      中別府雄作
    • Organizer
      日本遺伝学会第90回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Oxidative DNA damage and Repair in Cancer and Aging2018
    • Author(s)
      Yusaku Nakabeppu, Nona Abolhassani, Eiko Ohta, Zijing Sheng, Mizuki Ohno, Daisuke Tsuchimoto, Kunihiko Sakumi
    • Organizer
      The 14th Japan - Korea Joint Symposium on Cancer and Ageing Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Long-term exposure to high-fat diet significantly exacerbated cognitive deficit in aged AppNL-F/NL-F knock-in mouse model of Alzheimer’s disease along with persistent impaired glucose tolerance2018
    • Author(s)
      Nona Abolhassani, Ryohei Ikegami, Naoki Haruyama, Guianfranco Mazzei, Takashi Saito, Takaomi C Saido, Yusaku Nakabeppu
    • Organizer
      The 41st Annual Meeting of The Japan Neuroscience Society
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain2018
    • Author(s)
      7.Yusaku Nakabeppu, Sugako Oka, Julio Leon, Nona Abolhassani, Tomomi Ide, Dongchon Kang
    • Organizer
      The 30th International Conference of the Korean Society for Molecular and Cellular Biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] 活性酸素による核酸の酸化と脳の老化2018
    • Author(s)
      中別府雄作
    • Organizer
      第16回レドックス・ライフイノベーション シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis.2018
    • Author(s)
      Reiji Hommyo, Satoshi O Suzuki, Nona Abolhassani, Hideomi Hamasaki, Masahiro Shijo, Norihisa Maeda, Hiroyuki Honda, Yusaku Nakabeppu, Toru Iwaki
    • Organizer
      The 19th International Congress of Neuropathology, Tokyo.
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] アルツハイマー病を脳の糖尿病として捉える2018
    • Author(s)
      中別府 雄作
    • Organizer
      知の拠点セミナー
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Accumulation of 8-oxoguanine in nuclear genome of neural progenitors in aged mouse brain causes atrophy of major island of Calleja resulting in locomotor hyperactivity2018
    • Author(s)
      Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      The 41st Annual Meeting of The Japan Neuroscience Society
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Oxidative DNA damage and repair in Alzheimer’s disease brain2017
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      6th US-Japan DNA Repair Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] アルツハイマー病脳におけるインスリン産生・応答系の破綻とミトコンドリア機能障害2017
    • Author(s)
      中別府 雄作
    • Organizer
      医療薬学フォーラム 2017／第25回クリニカルファーマシーシンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Accumulation of 8-oxoguanine in the nuclei of newly-generated GABAergic neurons in the nucleus accumbens and islands of Calleja contributes to locomotor hyperactivity in aged mice2017
    • Author(s)
      Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      The 27th Hot Spring Harbor International Symposium
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] アルツハイマー病脳におけるミトコンドリア機能障害と炎症応答に起因する酸化ストレスの分子病態2017
    • Author(s)
      中別府 雄作
    • Organizer
      第59回日本老年医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] アルツハイマー病脳におけるインスリン枯渇とミトコンドリア機能不全に起因する酸化ストレスの分子病態2017
    • Author(s)
      中別府雄作
    • Organizer
      第13回レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2017-03-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15085

  • [Presentation] ラット脳発生およびヒト筋萎縮性側索硬化症におけるCRYMの発現変化2017
    • Author(s)
      本名 嶺治, 鈴木 諭, 濱崎 英臣, 本田 裕之, 北川 玲華, 司城　昌大, 前田 教寿, Nona Abolhassani, 中別府 雄作, 岩城 徹
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] 側坐核・カレハ島の新生GABAニューロンへの8-オキソグアニンの蓄積は加齢マウスの多動の原因となる2017
    • Author(s)
      春山 直樹, 作見 邦彦, 加藤木　敦央, 土本 大介, 中別府　雄作
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Protection of mitochondrial DNA from oxidative damage effectively blocks the mitochondria-mediated vicious cycle of Alzheimer's disease2017
    • Author(s)
      Yusaku Nakabeppu, Sugako Oka, Julio Leon, Nona Abolhassani, Tomomi Ide, Dongchon Kang
    • Organizer
      Consortium of Biological Sciences 2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Oxidative DNA damage and repair in carcinogenesis and neurodegeneration2017
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      International Symposium on Immune Diversity and Cancer Therapy Kobe 2017
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2017-01-26
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15085

  • [Presentation] Molecular Pathophysiology of Impaired Glucose Metabolism, Mitochondrial Dysfunction, and Oxidative DNA Damage in Alzheimer's Disease Brain2017
    • Author(s)
      Yusaku Nakabeppu, Naoki Haruyama, Guianfranco Mazzei, Ryouhei Ikegami, Nona Abolhassani
    • Organizer
      The 5th Annual World Congress of Geriatrics and Gerontology 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Impaired hippocampal neurogenesis in APP mouse model of Alzheimer disease2017
    • Author(s)
      Guianfranco Mazzei, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      Third International meeting in Bioscience (Young Peruvian Scientist Network)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] Nuclear accumulation of 8-oxoguanine in nucleus accumbens neurons contributes to age-related locomotor hyperactivity in Mth1/Ogg1-double knockout mice2017
    • Author(s)
      Naoki Haruyama, Atsuhisa Katogi, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      九州大学教育改革シンポジウム2017
    • Data Source
      KAKENHI-PROJECT-17H01391

  • [Presentation] アルツハイマー病進展における核あるいはミトコンドリアDNA中に蓄積した8-oxoguanineの役割2016
    • Author(s)
      岡　素雅子, 盛　子敬, フリオ　レオン, 土本 大介, 作見　邦彦, 中別府　雄作
    • Organizer
      第３９回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-26460490

  • [Presentation] アルツハイマー病進展における核あるいはミトコンドリアDNA中に蓄積した8-oxoguanineの役割2016
    • Author(s)
      岡 素雅子, 盛 子敬, フリオ レオン, 土本 大介, 作見 邦彦, 中別府 雄作
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K15085

  • [Presentation] Cranial irradiation causes hippocampal degeneration through accumulation of 8-oxoguanine in mitochondrial DNA in neurons2015
    • Author(s)
      Sheng Zijing, Nakabeppu Yusaku.
    • Organizer
      日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-26460490

  • [Presentation] MUTYH-dependent programmed cell death triggered by 8-oxoguanine and its implication in tumor suppression and neurodegeneration2015
    • Author(s)
      Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
    • Organizer
      15th International Congress of Radition Research
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-05-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460490

  • [Presentation] 8-Oxoguanine accumulated in mitochondrial DNA disturbs neuritic regeneration of cultured adult mouse cortical neurons under conditions of oxidative stress2015
    • Author(s)
      Julio Leon, Kunihiko Sakumi, Sugako Oka, Erika Castillo, Yusaku Nakabeppu
    • Organizer
      45th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2015-10-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15085

  • [Presentation] Cortical neurons isolated from adult Mth1/Ogg1-double-knockout mouse exhibit impaired neurite regeneration under conditions of oxidative stress2015
    • Author(s)
      Julio Jesusu Leon Incio, Kunihiko Sakumi, Sugako Oka, Erika Castillo, Yusaku Nakabeppu
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸市
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-15K15085

  • [Presentation] 活性酸素によるDNA損傷が引起こすさまざまな生命現象： 突然変異から神経変性まで2015
    • Author(s)
      中別府 雄作, 岡 素雅子, 盛 子敬, 大野 みずき, 土本 大介, 作見 邦彦
    • Organizer
      第17回 日本進化学会年大会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460490

  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) breaks the vicious circle of oxidative stress and amyloid β accumulation in triple-transgenic mouse model of Alzheimer’s disease2015
    • Author(s)
      Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      第38回日本分子生物学会年会, 第88回日本生化学会　合同大会　(神戸)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461281

  • [Presentation] アルツハイマー病脳における糖尿病関連遺伝子の発現異常：久山町研究2014
    • Author(s)
      中別府雄作
    • Organizer
      第46回城南神経懇話会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Oxidation of nucleic acids and control mechanisms of genetic diversity in mammals.2014
    • Author(s)
      Yusaku Nakabeppu, Mizuki Ohno, Ryutaro Fukumura, Yuki Iwasaki, Yoshimichi Ikemura, Teruhisa Tsuzuki, Yoichi Gondo, Kunihiko Sakumi
    • Organizer
      International Symposium on Germline Mutagenesis and Biodiversification
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 神経変性疾患と酸化ストレス2014
    • Author(s)
      中別府雄作
    • Organizer
      26th Japanese Science Seminar in Baltimore
    • Place of Presentation
      Baltimore, MD, U. S. A.
    • Year and Date
      2014-09-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-oxo-dGTP generated in nucleotide pools is a major cause of neurodegeneration under oxidative stress.2014
    • Author(s)
      Sheng Zijing, Sugako Oka, Yasuhiro Ikeda, Margherita Bignami, Yusaku Nakabeppu
    • Organizer
      International symposium "New Frontier of Molecular Neuropathology 2014"
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2014
    • Author(s)
      Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      EUROMIT2014 International Meeting on Mitochondrial Pathology
    • Place of Presentation
      TAMPERE FINLAND
    • Data Source
      KAKENHI-PROJECT-25461281

  • [Presentation] アルツハイマー病脳における遺伝子発現の変化と酸化ストレス2014
    • Author(s)
      中別府雄作
    • Organizer
      基盤研究(S)公開シンポジウム・環境親電子物質のレドックス制御
    • Place of Presentation
      つくば
    • Year and Date
      2014-10-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-Oxoguanine causes spontaneous de novo germline mutations : a study from the mutator mouse line.2014
    • Author(s)
      Mizuki Ohno, Kunihiko Sakumi, Ryutaro Fukumura, Yuki Iwasaki, Yoshimichi Ikemura, Teruhisa Tsuzuki, Yoichi Gondo, Yusaku Nakabeppu
    • Organizer
      SMBE Satellite Meeting/NIG International Symposium: The Causes of Genome Evolution
    • Place of Presentation
      三島
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Drinking “hydrogen water” induces ghrelin secretion and protects dopaminergic neurons in MPTP-induced Parkinson’s disease model mice.2014
    • Author(s)
      Megumi Yamafuji, Akio Matsumoto, Tomoko Tachibana, Yusaku Nakabeppu, Mami Noda, Haruyuki Nakaya
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Quantitative detection of oxidative DNA damage in brains of the triple transgenic Alzheimer’s disease mouse model2013
    • Author(s)
      Yoriko Akimoto, Sugako Oka, Julio Leon, Yusaku Nakabeppu
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      Boston, MA, USA
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair2013
    • Author(s)
      38. Zing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      Gordon research conference on Oxidative Stress & Disease
    • Place of Presentation
      Les Diablerets, Switzerland
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] アルツハイマー病脳における糖尿病関連遺伝子の発現異常：久山町研究2013
    • Author(s)
      外間政朗，岡素雅子，Julio Leon，二宮利治，本田裕之，佐々木健介，岩城徹，小原知之，清原裕，中別府雄作
    • Organizer
      第18回日本神経精神医学会
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性酸素による核酸の酸化と哺乳動物における遺伝子多様性の制御機構2013
    • Author(s)
      中別府雄作, 大野みずき, 作見邦彦
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Fosb遺伝子産物は補体C5aレセプターの遺伝子発現を制御することにより，ミクログリアの活性化に寄与している．2013
    • Author(s)
      能丸寛子，作見邦彦，加藤木敦央，大西克典，梶谷康介，土本大介，Eric J. Nestler， 中別府雄作
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性分子種による核酸の化学修飾と生体応答2013
    • Author(s)
      中別府 雄作
    • Organizer
      長崎大学がんゲノム不安定性研究拠点(NRGIC) 平成24年度第59回大学院セミナー
    • Place of Presentation
      長崎
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via caspase-independent cell death pathway2013
    • Author(s)
      岡素雅子, 中別府雄作
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer's disease model mice2013
    • Author(s)
      Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Quality control in the nucleotide pools is essential for cellular homeostasis.2013
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      Invited seminar at Istituto Superiore di Sanitá
    • Place of Presentation
      Roma, Italy
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice.2013
    • Author(s)
      Sugako Oka, Julio Leon, Masaaki Hokama, Atsuhisa Katogi, Sakumi Kunihiko, Dongchon Kang, Yusaku Nakabeppu
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior2013
    • Author(s)
      33. Noriko Yutsudo, Takashi Kamada, Kosuke Kajitani, Hiroko Nomaru, Atsuhisa Katogi, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kei-ichiro Takase, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice: the effect of low-level exposure2013
    • Author(s)
      續輝久, 大野みずき, 中津可道, 中別府雄作
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 核酸損傷と生体防御2013
    • Author(s)
      中別府雄作, 岡素雅子, 盛子敬, 土本大介, 作見邦彦
    • Organizer
      第24回日本生体防御学会学術集会
    • Place of Presentation
      熊本
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Cross-talk between insulin and other growth factors signaling regulate their neuroprotective functions.2013
    • Author(s)
      Julio Leon, Masaaki Hokama, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto, Erika Castillo, Yusaku Nakabeppu
    • Organizer
      11th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Molecular hydrogen protects against ischemic injury in optic nerves2013
    • Author(s)
      Megumi Yamafuji, Kyota Fujita, Margaret Hamner, Nozomi Akimoto, Mizuho A Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce Ransom, Mami Noda
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Dual effects of Galectin-1 in amyotrophic lateral screlosis.2013
    • Author(s)
      Yuko Kobayakawa, Kunihiko Sakumi, Yusaku Nakabeppu.
    • Organizer
      The 43rd annual meeting of the Society for neuroscience
    • Place of Presentation
      San Diego, CA, USA
    • Data Source
      KAKENHI-PUBLICLY-25110724

  • [Presentation] Striatal degeneration initiated by a mitochondrial toxin, 3-nitropropionic acid is dependent on MUTYH-initiated base excision repair of 8-oxoguanine-paired adenine.2013
    • Author(s)
      Yusaku Nakabeppu, Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi
    • Organizer
      11th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] デオキシイノシン三リン酸の蓄積はミスマッチ修復機構に依存した細胞増殖抑制とゲノム不安定性を引き起こす.2013
    • Author(s)
      米嶋康臣, 土本大介, 外間政朗, Abolhassani Nona, 猪山輝昭, 作見邦彦, 塩見尚子, 森 雅彦, 塩見忠博, 中別府雄作
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Oxidative damage in brain genomes and neuroprotective mechanisms.2013
    • Author(s)
      Yusaku Nakabeppu, Zijing Sheng, Sugako Oka
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer's disease model mice.2013
    • Author(s)
      岡素雅子, Julio Leon, 外間政朗, 加藤木敦央, 作見邦彦, 井手友美, Kang Dongchon, 中別府雄作
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] SOD1G93AトランスジェニックALSモデルマウスにおけるgalectin-1の発現2013
    • Author(s)
      中別府雄作
    • Organizer
      包括的脳科学研究推進支援ネットワーク 平成25 年度夏のワークショップ
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PUBLICLY-25110724

  • [Presentation] Comprehensive analysis of gene expression regulated by Fosb gene in brain-derived cells2013
    • Author(s)
      Hiroko Nomaru, Kunihiko Sakumi, Noriko Yutsudo, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study.2013
    • Author(s)
      中別府雄作, 外間政朗, 岡素雅子, Julio Leon, 二宮利治, 本田裕之, 佐々木健介, 岩城徹, 小原知之, Frank M. LaFerla, 清原裕
    • Organizer
      包括的脳科学研究推進支援ネットワーク 平成25年度夏のワークショップ
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH-dependent neurodegeneration initiated by mitochondrial accumulation of 8-oxoguanine in neurons is efficiently suppressed by MTH1 and OGG12013
    • Author(s)
      Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
    • Organizer
      10th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM)
    • Place of Presentation
      Seoul, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Fosb gene products regulate expression of C5ar1 and C5l2 genes and microglial activation.2013
    • Author(s)
      Hiroko Nomaru, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      The 43rd annual meeting of the Society for neuroscience
    • Place of Presentation
      San Diego. CA, USA.
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Neuroprotection and slow aging induced by oxidative stress-resistant signaling driven by medical gas2013
    • Author(s)
      Mami Noda, Kyota Fujita, Margaret Hamner, Chieri Higashi, Megumi Yamafuji, Nozomi Akimoto, Mizuho A Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce Ransom
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Expression of the defense enzymes MTH1, OGG1 and MUTYH against oxidative damage in nucleic acids in the mouse brain2013
    • Author(s)
      Zijing Sheng, Yusaku Nakabeppu
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2013
    • Author(s)
      Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi & Yusaku Nakabeppu
    • Organizer
      Gordon Research Conference on Oxidative Stress & Disease
    • Place of Presentation
      Les Diablerets, Switzerland
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 酸化DNA 損傷に起因するde novo germline mutationの解析 (II)2013
    • Author(s)
      作見邦彦, 大野みずき, 福村龍太郎, 権藤洋一, 岩崎裕貴, 池村淑道, 續輝久, 中別府 雄作
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Dual effects of Galectin-1 in amyotrophic lateral sclerosis2013
    • Author(s)
      Yuko Kobayakawa, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性分子種による核酸の化学修飾に起因する病態とその防御機構2013
    • Author(s)
      中別府雄作
    • Organizer
      老化促進モデルマウス(SAM)研究協議会 第28回研究発表会
    • Place of Presentation
      名古屋
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Dual effects of Galectin-1 in amyotrophic lateral screlosis.2013
    • Author(s)
      Yuko Kobayakawa, Kunihiko Sakumi, yusaku Nakabeppu
    • Organizer
      The 43rd annual meeting of the Society for neuroscience
    • Place of Presentation
      San Diego. CA, USA.
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Quantitative detection of oxidative DNA damage in brains of the triple transgenic Alzheimer's disease mouse model.2013
    • Author(s)
      Yoriko Akimoto, Sugako Oka, Yusaku Nakabeppu
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Control mechanism to maintain the low level of deoxyinosine in DNA.2013
    • Author(s)
      Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      Keystone Symposium on Genomic Instability and DNA Repair (X6)
    • Place of Presentation
      Banff, Alberta, Canada
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2013
    • Author(s)
      Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      Boston, MA, USA
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Cytotoxic effects of X-ray irradiation on proliferating and differentiated human neuroblastoma cell line SH-SY5Y, and their modulation by BDNF and inhibitors for CDK5 and calpains.2013
    • Author(s)
      Erika Castillo, Julio Leon, 秋本頼子, 作見邦彦, 岡素雅子, 土本大介, 中別府雄作
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性分子種による核酸の化学修飾に起因する病態とその防御機構2013
    • Author(s)
      中別府 雄作
    • Organizer
      山口大学遺伝子実験施設セミナー
    • Place of Presentation
      宇部
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 酸化DNA損傷と消化管がん．2013
    • Author(s)
      大野みずき, 中津可道, 中別府雄作, 續輝久
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Involvement of galectin-1 and galectin-3 in GDNF-induced neurite outgrowth from adult rat DRG neurons.2013
    • Author(s)
      Kazunori Sango, Shizuka Takaku, Hiroko Yanagisawa, Kazuhiko Watabe, Kunihiko Sakumi, Yusaku Nakabeppu, Francoise Poirier, Hidenori Horie, Toshihiko Kadoya
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PUBLICLY-25110724

  • [Presentation] Dual effects of Galectin-1 in amyotrophic lateral sclerosis.2013
    • Author(s)
      Yuko Kobayakawa, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      Neuro2013 Joint Conference
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PUBLICLY-25110724

  • [Presentation] 酸化DNA 損傷に起因するde novo germline mutationの解析2013
    • Author(s)
      大野みずき, 作見邦彦, 福村龍太郎, 権藤洋一, 岩崎裕貴, 池村淑道, 續輝久, 中別府 雄作
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia.2012
    • Author(s)
      H. Nomaru, N. Yutsudo, M. Hokoma, Y. Nakabeppu
    • Organizer
      The Munich Life Science Symposium for Young Scientist <interact> 2012(招待講演)
    • Place of Presentation
      Munich, Germany
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] 変異SOD1トランスジェニックマウスを用いた，筋萎縮性側索硬化症におけるガレクチン1の病態への関与の検討.2012
    • Author(s)
      小早川 優子，作見 邦彦，中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Mice lacking fosB display impaired adult hippocampal neurogenesis and spontaneous epilepsy2012
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      The 21st Hot spring Harbor Symposium jointly with 8th Global COE International Symposium, Young Investigators Presentation
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] Synergistic interaction between insulin and other growth factors modulates their neuroprotective functions.2012
    • Author(s)
      Julio Leon, Masaaki Hokama, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-Oxoguanine causes complex neurodegeneration in a MUTYH-dependent manner, which can be efficiently suppressed by MTH1 and/or OGG1.2012
    • Author(s)
      Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
    • Organizer
      The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
    • Place of Presentation
      Yumebutai, Awaji, Hyogo
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Identification and quantification of radiation-induced modified purine nucleosides。2012
    • Author(s)
      Yoriko Akimoto and Yusaku Nakabeppu,
    • Organizer
      The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
    • Place of Presentation
      The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Influence of 8-Oxoguanine on Mitotic and Meiotic Chromosome.2012
    • Author(s)
      Mizuki Ohno, Kunihiko Sakumi, Teruhisa Tsuzuki, Yusaku Nakabeppu
    • Organizer
      The 10th International Symposium on Chromosomal Aberrations
    • Place of Presentation
      Amalfi, Italy
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 酸化損傷塩基の修復機構は生殖細胞ゲノム変異を抑制し同系交配によるマウスの表現型の安定性に寄与する.2012
    • Author(s)
      大野 みずき，作見 邦彦，福村 龍太郎，権藤 洋一，續 輝久，中別府 雄作
    • Organizer
      日本環境変異学会第41回大会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression2012
    • Author(s)
      Sugako Oka, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      第35回日本がん疫学 分子疫学学会
    • Year and Date
      2012-07-05
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] Quality control in the nucleotide pools is essential for cellular homeostasis2012
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      Invited seminar at National Institute of Environmental Health Science, NIH
    • Place of Presentation
      RTP, NC, USA
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] fosB遺伝子産物によるアナフィラトキシンC5a 走化性受容体遺伝子C5arとGpr77の発現制御機構の解析.2012
    • Author(s)
      能丸 寛子，作見 邦彦，土本 大介，中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] fosB 遺伝子産物によるアナフィラトキシン C5a 走化性受容体遺伝子C5ar と Gpr77 の発現制御機構の解析2012
    • Author(s)
      能丸 寛子, 作見 邦彦, 土本 大介, 中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡.
    • Year and Date
      2012-09-25
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] 活性酸素による核酸の修飾とゲノム応答の遺伝学.2012
    • Author(s)
      中別府 雄作，土本 大介，盛 子敬，岡 素雅子，作見 邦彦
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] イノシン三リン酸によるゲノム不安定化機構と細胞内イノシン三リン酸生成経路の解明.2012
    • Author(s)
      米嶋 康臣，土本 大介，作見 邦彦，中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Base excision repair by MUTYH initiates calpain/PARP-dependent neurodegeneration under oxidative stress.2012
    • Author(s)
      Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Neurodegeneration caused by two distinct signaling pathways dependent on 8-oxoguanine and MUTYH-initiated base excision repair.2012
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      The 2012 International Symposium on “Signaling Functions of Reactive Oxygen Species”, Grants-in-Aid for Scientific Research on Innovative Areas, MEXT Japan
    • Place of Presentation
      Fukuoka
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-オキソグアニンの修復機構をノックアウトするマウスは，生殖細胞ゲノム中の突然変異頻度の上昇と遺伝性の変異形質を呈する.2012
    • Author(s)
      大野 みずき，作見 邦彦，福村 龍太郎，権藤 洋一，續輝久，中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-Oxoguanine, a spontaneously oxidized guanine base, promotes somatic and meiotic recombination, thus contributing to carcinogenesis and genomic diversity2012
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      Invited seminar at Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute, NIH
    • Place of Presentation
      Bethesda, MA. USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Cytotoxic effects of X-ray irradiation on proliferative and differentiated human neuroblastoma cell line, SH-SY5Y, and modulation by neurotrophic factors and CDK5 inhibitor.2012
    • Author(s)
      Erika Castillo, Julio Leon, Yoriko Akimoto, Yasuto Yoneshima, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Cooperative neuroprotection by insulin and neurotrophic factors.2012
    • Author(s)
      Julio Leon, Masaaki Hokama, Sugako Oka, Erika Castillo, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYHはp53による発がん抑制のメディエータである.2012
    • Author(s)
      岡 素雅子，レオン フリオ，土本 大介，作見 邦彦，中別府 雄作
    • Organizer
      第35回日本がん疫学・分子疫学研究会総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] fosB遺伝子産物によるアナフィラトキシンC5a走化性受容体遺伝子 C5arとGpr77の発現制御機構の解析2012
    • Author(s)
      能丸 寛子, 作見 邦彦, 土本 大介, 中別府 雄作
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] GDNFはRET-PI3K経路を介してDRGニューロンの神経突起伸長ならびにGalectin-1の発現を誘導する.2012
    • Author(s)
      高久 静香, 柳澤 比呂子, 渡部 和彦, 中別府 雄作, Francoise Poirier, 堀江 秀典, 門屋 利彦, 三五 一憲
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2012
    • Author(s)
      H.Nomaru, N.Yutsudo, M.Hokoma, Y.Nakabeppu
    • Organizer
      The munich Life Science Symposium for Young Scientist <interact>2012
    • Place of Presentation
      Munich, Germany(招待講演)
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] fosB遺伝子産物によるアナフィラトキシンC5a走化性受容体遺伝子C5arとGpr77の発現制御機構の解析.2012
    • Author(s)
      能丸 寛子，作見 邦彦，土本 大介，中別府 雄作
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 酸化ストレスは MUTYH による塩基除去 修復経路を介してcalpain/PARP 依存性の神経変性を引き起こす.2012
    • Author(s)
      盛 子敬，岡 素雅子，土本 大介，作見 邦彦，中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2012
    • Author(s)
      Hiroko Nomaru, Noriko Yutsudo, Yusaku Nakabeppu
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-18
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2012
    • Author(s)
      Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
    • Organizer
      The 9th ASMRM and Chinese Mit'2012
    • Place of Presentation
      Beijing, China
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides and defense systems in mammalian cells.2012
    • Author(s)
      Daisuke Tsuchimoto, Teruaki Iyama, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Tetsuo Noda and Yusaku Nakabeppu
    • Organizer
      4th US-JAPAN DNA REPAIR MEETING
    • Place of Presentation
      Virginia, USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 放射線照射によって生成される修飾ヌクレオシドの解析.2012
    • Author(s)
      秋本　頼子，中別府　雄作
    • Organizer
      第35回日本がん疫学・分子疫学研究会総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia.2012
    • Author(s)
      Hiroko Nomaru， Noriko Yutsudo， Yusaku Nakabeppu
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 哺乳動物のITP 分解酵素とエンドヌクレアーゼV.2012
    • Author(s)
      作見 邦彦，土本 大介，中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] アルツハイマー病脳における遺伝子発現プロファイリング-剖検脳とマウスモデルの比較解析-2012
    • Author(s)
      中別府雄作
    • Organizer
      グローバルCOEプログラム「個体恒常性を担う細胞運命の決定とその破綻」第5回事業推進担当者発表会
    • Place of Presentation
      福岡
    • Year and Date
      2012-02-21
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Mice lacking fosB display impaired adult hippocampal neurogenesis and spontaneous epilepsy2012
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      The 21st Hot spring Harbor Symposium jointly with 8th Global COE International Symposium, YoungInvestigatorsPresentation
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-01-21
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] Quality control in the nucleotide pools is essential for cellular homeostasis2012
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      Invited seminar at Laboratory of Molecular Gerontology, National Institute on Aging, NIH
    • Place of Presentation
      Baltimore, MD USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Altered expression of diabetes-related genes in Alzheimer's disease brains.2012
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      11th Surugadai International Symposium
    • Place of Presentation
      Tokyo
    • Invited
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 放射線照射によって生成されるプリンヌクレオシドの修飾体の同定と定量.2012
    • Author(s)
      秋本 頼子，中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 酸化損傷塩基の修復機構をノックアウトするマウス家系の解析.2012
    • Author(s)
      大野 みずき，作見 邦彦，福村 龍太郎，権藤 洋一，田口健一，續 輝久，中別府 雄作
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides.2012
    • Author(s)
      Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Nakabeppu Y, Samson LD
    • Organizer
      7th Annual CEHS Poster Session
    • Place of Presentation
      Cambridge, MA, USA
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2012
    • Author(s)
      Nomaru H, Yutsudo N, Hokoma M, Nakabeppu Y
    • Organizer
      The Munich Life Science Symposium for Young Scientist 2012
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] fosB 遺伝子産物によるアナフィラトキシン C5a 走化性受容体遺伝子C5ar と Gpr77 の発現制御機構の解析2012
    • Author(s)
      能丸 寛子, 作見 邦彦, 土本 大介, 中別府 雄作
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] Obesity and altered expression of genes related to Diabetes-mellitus in Alzheimer’s disease mouse model.2012
    • Author(s)
      Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Mice lacking fosB display impaired adult hippocampal neurogenesis and spontaneous epilepsy2012
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H.Ohnishi, Yoshinori N.Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      The 21^<st> Hot spring Harbor Symposium jointly with 8^<th> Global COE International Symposium, Young Investigators Presentation
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-01-21
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] fosB 遺伝子産物によるアナフィラトキシンC5a 走化性受容体遺伝子C5ar とGpr77 の発現制御機構の解析2012
    • Author(s)
      能丸 寛子, 作見 邦彦, 土本 大介, 中別府 雄作
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] Obesity and altered expression of genes related to diabetes mellitus in a transgenic mouse model of Alzheimer's disease.2012
    • Author(s)
      Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 2-OH-ATP as a signal molecule for the oxidative stress in mammalian cells。2012
    • Author(s)
      Eiko Ohta, Kunihiko Sakumi, Daisuke Tsuchimoto, Yuka Takiguchi and Yusaku Nakabeppu
    • Organizer
      The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
    • Place of Presentation
      The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Alzheimer’s disease mouse model exhibits altered expression of genes related to diabetes-mellitus with obesity.2012
    • Author(s)
      Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 筋萎縮性側索硬化症におけるGalectin-1の病態への関与.2012
    • Author(s)
      小早川 優子，作見 邦彦，中別府 雄作
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] DNA中のデオキシイノシン量を制御するメカニズム.2012
    • Author(s)
      作見 邦彦，中別府 雄作
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] The molecular neurobiology of anti-oxidative stress induced by hydrogen2011
    • Author(s)
      Mami Noda, Kyota Fujita, Mizuho A.Kido, Yusaku Nakabeppu
    • Organizer
      7th Congress of the Federation of Asian and Oceanian Physiological Societies (FAOPS)
    • Place of Presentation
      Taipei Taiwan(招待講演)
    • Year and Date
      2011-09-12
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Roles of insulin in survival and proliferation of SH-SY5Y neuroblastoma cells under neuronal differentiation2011
    • Author(s)
      Julio Leon, Masaaki Hokama, Sugako Oka, Erika Castillo, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 脳内細胞における fosB による遺伝子プロファイルの網羅的解析2011
    • Author(s)
      能丸 寛子,大西 克典,外間 政朗,湯通堂 紀子,中別府 雄作
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2011
    • Author(s)
      H. Nomaru, N. Yutsudo, M. Hokoma, Y. Nakabeppu
    • Organizer
      41st Annual meeting of Society for Neuroscienc
    • Place of Presentation
      Washington, DC, USA
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAsKeystone Symposia Stem Cells2011
    • Author(s)
      Sugako Oka, Yusaku Nakabeppu
    • Organizer
      Cancer and Metastasis
    • Place of Presentation
      USA
    • Year and Date
      2011-03-08
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures2011
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H.Ohnishi, Yoshinori N.Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      Neurogenesis 2011
    • Place of Presentation
      Kobe
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
    • Author(s)
      Sugako Oka, Julio Leon, Yusaku Nakabeppu
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] MUTYHはp53による発がん抑制のメディエータである2011
    • Author(s)
      岡素雅子, フリオレオン, 作見邦彦, 土本大介, 中別府雄作
    • Organizer
      第40回日本環境変異原学会シンポジウム
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-21
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
    • Author(s)
      Sugako Oka, Julio Leon, Yusaku Nakabeppu
    • Organizer
      第34回日本分子生物学会口頭、ポスター
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] ΔFosB/Δ2ΔFosBは成体海馬神経前駆細胞の増殖制御とてんかん自然発症の抑制に働く2011
    • Author(s)
      湯通堂紀子, 鎌田崇嗣, 能丸寛子, 大西(本田)陽子, 大西克典, 梶谷康介, 作見邦彦, 重藤寛史, 中別府雄作
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] マウス黒質における核酸の酸化損傷防御酵素群, MTH1,OGG1,MUTYHの領域特異的な発現2011
    • Author(s)
      盛子敬, 中別府雄作
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs.2011
    • Author(s)
      Sugako Oka, Yusaku Nakabeppu
    • Organizer
      Keystone Symposia on Stem Cells, Cancer and Metastasis
    • Place of Presentation
      Keystone, Colorado, USA
    • Year and Date
      2011-03-08
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Fosb products regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures2011
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H.Ohnishi, Yoshinori N.Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      2011 International Summer Conference for Neurons and Brain Disease
    • Place of Presentation
      Toyama
    • Year and Date
      2011-08-04
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
    • Author(s)
      Sugako Oka, Julio Leon, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      日本環境変異原学会第40回大会 (シンポジウム)
    • Place of Presentation
      東京
    • Year and Date
      2011-11-21
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] ΔFosB/Δ2ΔFosB は成体海馬神経前駆細胞の増殖制御とてんかん自然発症の抑制に働く2011
    • Author(s)
      湯通堂 紀子, 鎌田 崇嗣, 能丸 寛子, 大西(本田) 陽子, 大西 克典, 梶谷 康介, 作見 邦彦, 重藤 寛史, 中別府 雄作
    • Organizer
      第34回日本神経 科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] 酸化ヌクレオチド2-OH-ATPによる細胞死の制御機構2011
    • Author(s)
      太田詠子, 土本大介, 作見邦彦, 瀧口友香, 中別府雄作
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2011
    • Author(s)
      H. Nomaru, N. Yutsudo, M. Hokoma, Y. Nakabeppu
    • Organizer
      41st Annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington, DC, USA.
    • Year and Date
      2011-11-15
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] Ogg1, Mth1, Mutyh triple knockout mouseの樹立と解析2011
    • Author(s)
      作見邦彦, 大野みずき, 田口健一, 外間政朗, 中別府雄作
    • Organizer
      「個体レベルでの発がん研究支援活動」ワークショップ
    • Place of Presentation
      大津
    • Year and Date
      2011-02-03
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Defects of DNA repair systems against oxidative mutagenesis : implication in oxidative-stress induced carcinogenesis2011
    • Author(s)
      Yoshimichi Nakatsu, Jing Shu Piao, Takuro Isoda, Kunihiko Sakumi, Yusaku Nakabeppu, Teruhisa Tsuzuki
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 脳内細胞におけるfosBによる遺伝子プロファイルの網羅的解析2011
    • Author(s)
      能丸寛子, 大西克典, 外間政朗, 湯通堂紀子, 中別府雄作
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Comprehensive analysis of gene expression regulated by fosB gene in neuron and glia2011
    • Author(s)
      H.Nomaru, N.Yutsudo, M.Hokoma, Y.Nakabeppu
    • Organizer
      41^<st> Annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2011-11-15
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 剖検脳マイクロアレイ解析による脳疾患遺伝子発現プロファイリング2011
    • Author(s)
      外間政朗, 岩城徹, 清原裕, 佐々木富男, 中別府雄作
    • Organizer
      脳神経外科学会第70回学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-13
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Fosb products regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures2011
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      2011 International Summer Conference for Neurons and Brain Disease
    • Place of Presentation
      Toyama
    • Year and Date
      2011-08-04
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] Hydrogen confers resistance to neuronal loss on dopaminergic neurons in mice model of Parkinson's disease2011
    • Author(s)
      K.Fujita, F.Inoue; M.Yamafuji, K.Beppu, M.A.Kido, Y.Tanaka, Y.Nakabeppu, M.Noda
    • Organizer
      41^<st> Annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2011-11-12
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性分子種による核酸の化学修飾と生体応答2011
    • Author(s)
      中別府雄作, 猪山輝昭, 岡素雅子, 盛子敬, 作見邦彦, 土本大介
    • Organizer
      第2回 Molecular Cardiovascular Conference
    • Place of Presentation
      余市(招待講演)
    • Year and Date
      2011-09-04
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性分子種による核酸の化学修飾と生体応答2011
    • Author(s)
      中別府雄作
    • Organizer
      日本植物学会第75回大会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2011
    • Author(s)
      Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      6th Global-COE Young Investigators Forum
    • Place of Presentation
      Bintan Isaland, Indonesia.
    • Year and Date
      2011-02-12
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Fosb products regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures.2011
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      2011 International Summer Conference for Neurons and Brain Disease
    • Place of Presentation
      Toyama
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] アルツハイマー病の分子機構～遺伝子発現機構からのアプローチ2011
    • Author(s)
      中別府雄作
    • Organizer
      Hisayama Study Conference 2011
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] ΔFosB/Δ2ΔFosB は成体海馬神経前駆細胞の増殖制御とてんかん自然発症の抑制に働く2011
    • Author(s)
      湯通堂 紀子，鎌田 崇嗣，能丸 寛子，大西（本田） 陽子，大西 克典，梶谷 康介，作見 邦彦，重藤 寛史，中別府 雄作
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] Gene expression prefiling of postmortem brains of patients with Alzheimer's disease pathology : The Hisayama Study2011
    • Author(s)
      M.Hokama, T.Iwaki, K.Sasaki, Y.Kiyohara, T.Sasaki, Y.Nakabeppu
    • Organizer
      41^<st> Annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2011-11-16
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2011
    • Author(s)
      Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      Keystone Symposia on Genomic Instability and DNA Repair
    • Place of Presentation
      Keystone, Colorado, USA.
    • Year and Date
      2011-02-01
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] ほ乳動物細胞におけるデオキシイノシンヌクレオチドによるゲノム不安定化とその防御機構2011
    • Author(s)
      土本大介, 猪山輝昭, アボルハッサニノナ, 米嶋康臣, 作見邦彦, 中別府雄作
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-20
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-OxoguanineはDNA鎖切断を誘発することで減数分裂期の相同染色体組換え頻度を上昇させる2011
    • Author(s)
      大野みずき, 作見邦彦, 古市正人, 中西恵美, 續輝久, 中別府雄作
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYHはp53による発がん抑制のメディエータである2011
    • Author(s)
      岡素雅子, レオンフリオ, 作見邦彦, 土木大介, 中別府雄作
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 脳内細胞におけるfosBによる遺伝子プロファイルの網羅的解析2011
    • Author(s)
      能丸 寛子，大西 克典，外間 政朗，湯通堂 紀子，中別府 雄作
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] 2-OH-ATP as a candidate molecule for the oxidative stress sensor in mammalian cells2011
    • Author(s)
      Kunihiko Sakumi, Eiko Ohta, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures.2011
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      Neurogenesis 2011
    • Place of Presentation
      Kobe
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression2011
    • Author(s)
      Sugako Oka, Julio Leon, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      日本環境変異原学会第40回大会シンポジウム発表
    • Place of Presentation
      東京一橋記念講堂
    • Year and Date
      2011-11-21
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides and defense systems in mammalian cells2011
    • Author(s)
      Daisuke Tsuchimoto, Teruaki Iyama, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Yusaku Nakabeppu
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures2011
    • Author(s)
      Noriko Yutsudo, Takashi Kamada, Hiroko Nomaru, Yoko H. Ohnishi, Yoshinori N. Ohnishi, Kosuke Kajitani, Kunihiko Sakumi, Hiroshi Shigeto, Yusaku Nakabeppu
    • Organizer
      Neurogenesis 2011
    • Place of Presentation
      Kobe
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-23657116

  • [Presentation] 8-Oxoguanine, a spontaneously oxidized guanine base, promotes somatic and meiotic recombination, thus contributing to carcinogenesis and genomic diversity2011
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      The 5th Biennial Meetin of Society for Free Radical Research-Asia (SFRR-Asia), 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), and 11th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit)
    • Place of Presentation
      Kagoshima(招待講演)
    • Year and Date
      2011-09-02
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 酸化ストレスはDNA修復酵素MUTYHに依存して神経変性を引き起こす2011
    • Author(s)
      盛子敬, 岡素雅子, 土本大介, 作見邦彦, 中別府雄作
    • Organizer
      第4回Kyushu CVD Conference
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-11-19
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 酸化ヌクレオチド2-OH-ATPによる細胞死の制御機構2010
    • Author(s)
      太田詠子, 土本大介, 作見邦彦, 中別府雄作
    • Organizer
      B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs2010
    • Author(s)
      Sugako Oka, Julio Leon, Yusaku Nakabeppu
    • Organizer
      国際3R会議
    • Place of Presentation
      富山
    • Year and Date
      2010-10-27
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] NUDT16は(デオキシ)イノシン二リン酸分解酵素であり,その欠損は核DNAの一本鎖切断の蓄積と増殖抑制をもたらす2010
    • Author(s)
      土本大介, 猪山輝昭, アボルハッサニ ノナ, 野中麻里, 中別府雄作
    • Organizer
      B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] The biological significance of ITPA protein and its substrates, ITP and dITP in mouse2010
    • Author(s)
      Kunihiko Sakumi, Nona Abolhassani, Mehrdad Behmanesh, Teruaki Iyama, Daisuke Tsuchimoto, Yusaku Nakabeppu
    • Organizer
      B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Base excision repair-mediated programmed cell death and neurodegeneration2010
    • Author(s)
      Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
    • Organizer
      3rd International Genome Dynamics in Neurosciences Conference "DNA Repair and Neurological disease"
    • Place of Presentation
      Brighton, UK
    • Year and Date
      2010-07-19
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH, a molecular switch for programmed cell death and tumor suppression2010
    • Author(s)
      S Oka, Y Nakabeppu
    • Organizer
      AACR/JCA 8th Joint Conference
    • Place of Presentation
      Waikoloa, Hawai, USA
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs.2010
    • Author(s)
      Sugako Oka, Zijing Sheng, Yusaku Nakabeppu
    • Organizer
      The 7th 3R (Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2010-10-26
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 核酸の酸化がもたらす生体障害とその防御機構2010
    • Author(s)
      中別府雄作
    • Organizer
      第26回臨床フリーラジカル会議
    • Place of Presentation
      大津
    • Year and Date
      2010-01-30
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYH, a molecular switch for programmed cell death and tumor suppression.2010
    • Author(s)
      S Oka, Y Nakabeppu
    • Organizer
      AACR/JCA 8th Joint Conference
    • Place of Presentation
      Waikoloa, Hawai, USA
    • Year and Date
      2010-02-07
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYHはp53による発がん抑制のメディエータである2010
    • Author(s)
      岡素雅子, 中別府雄作
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Quality control in the purine nucleotide pools is essential for maintaining genomic integrity in mammals.2010
    • Author(s)
      Yusaku Nakabeppu, Nona Abolhassani, Teruaki Iyama, Zijing Sheng, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto
    • Organizer
      The 7th 3R (Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2010-10-29
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2010
    • Author(s)
      Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Mari Nonaka, Yusaku Nakabeppu
    • Organizer
      The 7th 3R (Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2010-10-26
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性分子種による核酸の化学修飾と生体応答2010
    • Author(s)
      中別府雄作
    • Organizer
      第51回日本生化学会 中国・四国支部例会シンポジウム
    • Place of Presentation
      山口
    • Year and Date
      2010-05-14
    • Data Source
      KAKENHI-PROJECT-22241013

  • [Presentation] Molecular mechanisms for oxidative DNA damage-induced neurodegeneration.2010
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      The 7th Conference of Asian Society for Mitochondrial Research and Medicine
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2010-12-15
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression2010
    • Author(s)
      Sugako Oka, Yusaku Nakabeppu
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻に起因するゲノム障害とその防御機構2010
    • Author(s)
      中別府雄作, Nona Abolhassani, 猪山輝昭, 太田詠子, 盛子敬, 岡素雅子, 土本大介, 作見邦彦
    • Organizer
      B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Deoxyinosine incorporated into DNA under ITPA deficiency2010
    • Author(s)
      Nona Abolhassani, Teruaki Iyama, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      日本遺伝学会第82回大会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
    • Author(s)
      Nona Abolhassani, Teruaki Iyama, Daisuke Tsuchimoto, Kunihiko Sakumi, Mizuki Ohno, Mehrdad Behmanesh, Yusaku Nakabeppu
    • Organizer
      The 7th 3R (Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2010-10-26
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性酸素による核酸の損傷と神経変性の機序2010
    • Author(s)
      中別府雄作
    • Organizer
      第3回 Kyushu CVD Conference
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-20
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYHはp53による発がん抑制のメディエータである2010
    • Author(s)
      岡素雅子, フリオレオン, 中別府雄作
    • Organizer
      B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice2010
    • Author(s)
      Teruhisa Tsuzuki, Jing Shu Piao, Takuro Isoda, Kunihiko Sakumi, Yusaku Nakabeppu, Yoshimichi Nakatsu
    • Organizer
      Bond Workshop : Biological effects of low-level exposure to ionizing radiation, health risks and clinical consequences
    • Place of Presentation
      Richland, Washington, USA
    • Year and Date
      2010-05-03
    • Data Source
      KAKENHI-PROJECT-22241013

  • [Presentation] Mitochondrial toxin, 3-nitropropionic acid induces striatal degeneration through the two distinct MUTYH-dependent cell death pathways.2010
    • Author(s)
      Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      The 7th 3R (Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2010-10-26
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 8-oxoguanineはDNA 鎖切断を誘発することで減数分裂期の相同染色体組換え頻度を上昇させる2010
    • Author(s)
      大野みずき, 作見邦彦, 續輝久, 中別府雄作
    • Organizer
      B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態2010
    • Author(s)
      中別府雄作, 猪山輝昭, Nona Abolhassani, 太田詠子, 盛子敬, 岡素雅子, 作見邦彦, 土本大介
    • Organizer
      日本遺伝学会第82回大会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] 活性分子種による核酸の化学修飾と生体応答2010
    • Author(s)
      中別府雄作
    • Organizer
      第51回日本生化学会 中国・四国支部例会シンポジウム
    • Place of Presentation
      山口
    • Year and Date
      2010-05-14
    • Data Source
      KAKENHI-PROJECT-22221004

  • [Presentation] MUTYHはp53による発がん抑制のメディエータである2010
    • Author(s)
      岡 素雅子、レオン フリオ、中別府雄作
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-22501014

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression2009
    • Author(s)
      S Oka, Y Nakabeppu
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Oxidative genomic damage in brain and neuroprotection.2009
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      The Joint Symposium of the 4th International Symposium of Institutes Network and Osaka University Global COE (Frontier Biomedical Science Underlying Organelle Network Biology) Symposium
    • Place of Presentation
      Osaka
    • Year and Date
      2009-02-01
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression.2009
    • Author(s)
      S Oka, J J Leon-Incio, Y Nakabeppu
    • Organizer
      第33回日本分子生物学会年会/第83回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 8-Oxoguanine promotes base substitution and homologous recombination in mammalian germ cells.2009
    • Author(s)
      M Ohno, M Furuichi, K Sakumi, Y Nakabeppu
    • Organizer
      The 3rd ASM Conference on DNA Repair and Mutagenesis: From Molecular Structure to Human Disease
    • Place of Presentation
      Whistler, Canada
    • Year and Date
      2009-05-31
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Base excision repair-mediated programmed cell death responsible for tumor suppression and neurodegeneration2009
    • Author(s)
      Y Nakabeppu, S Oka, Z Sheng, D Tsuchimoto, K Sakumi
    • Organizer
      4th International Workshop on Cell Regulations in Division and Arrest
    • Place of Presentation
      Okinawa
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYH is a potential mediator of p53 tumor suppression2009
    • Author(s)
      S Oka, J J Leon-Incio, Y Nakabeppu
    • Organizer
      第33回日本分子生物学会年会/第83回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYH, A MOLECULAR SWITCH FOR PROGRAMMED CELL DEATH AND TUMOR SUPPRESSION2009
    • Author(s)
      S Oka, M Ohno, D Tsuchimoto, K Sakumi, Y Nakabeppu
    • Organizer
      The Fortieth International Symposium of The Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-11-10
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 8-Oxoguanine promotes base substitution and homologous recombination in mammalian germ cells2009
    • Author(s)
      M Ohno, M Furuichi, K Sakumi, Y Nakabeppu
    • Organizer
      The 3rd ASM Conference on DNA Repair and Mutagenesis
    • Place of Presentation
      Whistler, Canada
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 核酸の酸化と細胞死のシグナル伝達2009
    • Author(s)
      中別府雄作
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-28
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 酸化損傷塩基の修復能を欠損するマウスにおける継世代的影響の解析2009
    • Author(s)
      大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
    • Organizer
      日本遺伝学会第81回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 酸化的DNA損傷と生殖細胞ゲノム変異2009
    • Author(s)
      大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
    • Organizer
      日本環境変異原学会
    • Place of Presentation
      静岡
    • Year and Date
      2009-11-26
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Oxidative damage in nucleic acids and mitochondrial dysfunction2009
    • Author(s)
      Y Nakabeppu
    • Organizer
      SFRR International Summer School 2009 in Japan
    • Place of Presentation
      Minamiuonuma
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 酸化的DNA損傷と生殖細胞ゲノム変異2009
    • Author(s)
      大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Identification of the full-length form of Prune2, a neuroblastoma-related protein.2009
    • Author(s)
      aisuke Tsuchimoto, Eiji Iwama, Teruaki Iyama, Yusaku Nakabeppu
    • Organizer
      2009年第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Presentation] Oxidative Stress-Induced Tumorigenesis in the Small Intestine of Various DNA Repair-Deficient Mice2009
    • Author(s)
      T Tsuzuki, J Piao, T Isoda, K Sakumi, Y Nakabeppu, Y Nakatsu
    • Organizer
      The 3rd ASM Conference on DNA Repair and Mutagenesis
    • Place of Presentation
      Whistler, Canada
    • Year and Date
      2009-05-31
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Mitochondrial toxin, 3-nitropropionic acid induces MUTYH-dependent striatal degeneration.2009
    • Author(s)
      Z Sheng, H Yamada, Y Nakabeppu.
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYH, A MOLECULAR SWITCH FOR PROGRAMMED CELL DEATH AND TUMOR SUPPRESSION2009
    • Author(s)
      S Oka, M Ohno, D Tsuchimoto, K Sakumi, Y Nakabeppu
    • Organizer
      The Fortieth International Symposium of The Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Base excision repair-mediated programmed cell death responsible for tumor suppression and neurodegeneration2009
    • Author(s)
      Y Nakabeppu, S Oka, Z Sheng, D Tsuchimoto, K Sakumi
    • Organizer
      4th International Workshop on Cell Regulations in Division and Arrest
    • Place of Presentation
      沖縄
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Human NUDT16 Is a Novel Nucleotide Pool Sanitizing Enzyme Hydrolyzing (Deoxy)Inosine Diphosphate to (Deoxy)Inosine Monophosphate.2009
    • Author(s)
      Teruaki Iyama, Daisuke Tsuchimoto, Nona Abolhassani, Yusaku Nakabeppu
    • Organizer
      The 49th annual meeting of the American Society for Cell Biology, San Diego Convention Center, San Diego
    • Place of Presentation
      CA, USA
    • Year and Date
      2009-12-07
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Presentation] MUTYH, a molecular switch for programmed cell death under oxidative stress-friend or foe?2009
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      The 3rd Global COE International Symposium on Stem Cells and Regenerative Medicine
    • Place of Presentation
      Singapore
    • Year and Date
      2009-02-15
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Production and analysis of the Ogg1, Mth1, Mutyh triple knockout mouse strain2009
    • Author(s)
      K Sakumi, M Ohno, K Taguchi, M Hokama, Y Nakatsu, T Tsuzuki, Y Nakabeppu
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Oxidative damage in nucleic acids and mitochondrial dysfunction.2009
    • Author(s)
      Y Nakabeppu
    • Organizer
      SFRR International Summer School 2009 in Japan
    • Place of Presentation
      Minamiuonuma
    • Year and Date
      2009-09-05
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] ヒトnudt16は(デオキシ)イノシン二リン酸を(デオキシ)イノシン一リン酸に加水分解する新規ヌクレオチドプール浄化酵素である2009
    • Author(s)
      土本大介、猪山輝昭、アボルハッサニ・ノナ、中別府雄作
    • Organizer
      2009年第20回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      滋賀県彦根市琵琶湖コンファレンスセンター
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Presentation] 核酸の酸化とプログラム細胞死2009
    • Author(s)
      中別府雄作
    • Organizer
      レドックス170委員会第20回研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-23
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Programmed cell death triggered by nucleotide pool damage.2009
    • Author(s)
      Y Nakabeppu, E Ohta, J Ichikawa, D Tsuchimoto
    • Organizer
      The 10th International Conference on Environmental Mutagenesis (ICEM)
    • Place of Presentation
      Italy
    • Year and Date
      2009-08-21
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYH-dependent cell death and neurodegeneration2009
    • Author(s)
      Z Sheng, S Oka, Y Nakabeppu
    • Organizer
      The 2nd Erling Seeberg symposium on DNA repair
    • Place of Presentation
      Alesund-Geiranger, Norway
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYH-dependent cell death and neurodegeneration2009
    • Author(s)
      Z Sheng, S Oka, Y Nakabeppu
    • Organizer
      The 2nd Erling Seeberg symposium on DNA repair
    • Place of Presentation
      Norway
    • Year and Date
      2009-06-22
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Programmed cell death triggered by nucleotide pool damage2009
    • Author(s)
      Y Nakabeppu, E Ohta, J Ichikawa, D Tsuchimoto
    • Organizer
      The 10th International Conference on Environmental Mutagenesis
    • Place of Presentation
      Firenze, Italy
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 酸化ヌクレオチドによるシグナル伝達2009
    • Author(s)
      太田詠子, 土本大介, 中別府雄作
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Oxidative damage in brain genome and neuroprotection.2009
    • Author(s)
      Yusaku Nakabeppu
    • Organizer
      The 11th Meeting of Hirosaki International Forum of Medical Science Emerging Frontiers in Brain Research -Crossroads of metabolic regulation, stress response and disease
    • Place of Presentation
      Hirosaki
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Overview of programmed cell death and oxidative stress.2008
    • Author(s)
      中別府雄作
    • Organizer
      第8回日本ミトコンドリア学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-18
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] The mitochondrial toxin, 3-nitropropionic acid induces MUTYH-dependent striatal neurodegeneration with accumulation of 8-oxoguanine which is effectively suppressed by OGG1 and MTH1.2008
    • Author(s)
      Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
    • Organizer
      The 5th ASMRM and Chinese Mit'2008
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2008-11-09
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 8-オキソグアニンは染色体組換えを促進し, ゲノム多様性の原因となる2008
    • Author(s)
      大野みずき, 作見邦彦, 中別府雄作
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-04
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] OGG1 and MTH1 effectively suppress accumulation of 8-oxoguanine in striatal medium spiny neurons and their degeneration induced by mitochondrial toxin, 3-nitropropionic acid.2008
    • Author(s)
      Sheng Zijing, Hidetaka Yamada, Yusaku Nakabeppu
    • Organizer
      第31回日本神経科学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] OGG1/MTH1/MUTYH三重欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す2008
    • Author(s)
      大野みずき, 作見邦彦, 古市正人, 中別府雄作
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 新規損傷ヌクレオチド浄化酵素ITPBP2の同定と機能解析2008
    • Author(s)
      土本大介、吉田菜桜子、中別府雄作
    • Organizer
      2008年第31回日本分子生物学会・第81回日本生化学会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Presentation] 哺乳動物細胞における2-OH-ATPの生物学的影響2008
    • Author(s)
      太田詠子、土本大介、大野みずき、作見邦彦、中別府雄作
    • Organizer
      2008年第31回日本分子生物学会・第81回日本生化学会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Presentation] DNA修復関連遺伝子欠損マウスにおける酸化ストレス誘発消化管発がん2008
    • Author(s)
      中津可道, 朴晶淑, 磯田拓郎, 續輝久, 作見邦彦, 中別府雄作
    • Organizer
      がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-22
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Overview of programmed cell death and oxidative stress2008
    • Author(s)
      中別府雄作
    • Organizer
      第8回日本ミトコンドリア学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-18
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] MUTYHは核とミトコンドリアDNA中の8-オキソグアニンの制御により2つの異なる細胞死経路を引き起こす2008
    • Author(s)
      岡素雅子, 大野みずき, 土本大介, 作見邦彦, 古市正人, 中別府雄作
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 8-Oxoguanine is a major cause for the genome instability and diversity through enhancing the somatic and meiotic recombination.2008
    • Author(s)
      Mizuki Ohno, Yusaku Nakabeppu
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      宜野湾
    • Year and Date
      2008-12-04
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Novel pathway for hydrolysis of inosine nucleotides detected in immortalized ITPA-null mouse embryo fibroblasts2008
    • Author(s)
      アボルハッサニ・ノナ、作見邦彦、大野みずき、土本大介、ベーマネッシュ・メールダート、中別府雄作
    • Organizer
      2008年第31回日本分子生物学会・第81回日本生化学会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Presentation] 8-Oxoguanine promotes genetic diversity through enhancing meiotic recombination2008
    • Author(s)
      Mizuki Ohno, Masato Furuichi, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      XX International Congress of Genetics
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2008-07-12
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] OGG1/MTH1/UTYH三重欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す2008
    • Author(s)
      大野みずき, 作見邦彦, 古市正人, 中別府雄作
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 核とミトコンドリアゲノムへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死2008
    • Author(s)
      岡素雅子、大野みずき、土本大介、作見邦彦、中別府雄作
    • Organizer
      2008年第31回日本分子生物学会・第81回日本生化学会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19390114

  • [Presentation] MUTYHは核とミトコンドリアDNA中の8-オキソグアニンの制御により2つの異なる細胞死経路を引き起こす2008
    • Author(s)
      岡素雅子, 大野みずき, 土本大介, 作見邦彦, 古市正人, 中別府雄作
    • Organizer
      第67回日本癌学会学術総会(シンポジウム)
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 核とミトコンドリアDNAへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死2008
    • Author(s)
      岡素雅子, 大野みずき, 土本大介, 作見邦彦, 中別府雄作
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] ミトコンドリア毒3-ニトロプロピオン酸は8-オキソグアニンの蓄積を伴うMUTYH依存性の線条体変性を誘発するが, MTH1とOGG1により抑制される2008
    • Author(s)
      中別府雄作, 盛子敬, 岡素雅子
    • Organizer
      第8回日本ミトコンドリア学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-20
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Msh2遺伝子欠損マウスにおける酸化ストレス誘発小腸腫瘍の解析2008
    • Author(s)
      朴晶淑, 中津可道, 磯田拓郎, 續輝久, 作見邦彦, 中別府雄作
    • Organizer
      がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-22
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] ミトコンドリアヌクレオチドプールの酸化に起因する細胞死とその防御機構2008
    • Author(s)
      中別府雄作, 市川淳二, 岡素雅子, 大野みずき, 太田詠子, 土本大介, 作見邦彦
    • Organizer
      第61回日本酸化ストレス学会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-20
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 8-Oxoguanine, a major form of spontaneously oxidized guanine base, promotes genome diversity through enhancing chromosome recombination.2008
    • Author(s)
      Mizuki Ohno, Yusaku Nakabeppu
    • Organizer
      The 6th 3R (Replication, recombination, repair) Symposim
    • Place of Presentation
      Kakegawa
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 活性酸素によるゲノム障害とその防御機構-発がんと神経変性の分子病態-2008
    • Author(s)
      中別府雄作
    • Organizer
      第27回分子病理学研究会
    • Place of Presentation
      神奈川県三浦郡葉山町
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Ogg1/Mth1/Mutyh三重遺伝子欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す2008
    • Author(s)
      野みずき, 作見邦彦, 古市正人, 中別府雄作
    • Organizer
      日本遺伝学会第80回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-03
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 核とミトコンドリアDNAへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死2008
    • Author(s)
      岡素雅子, 大野みずき, 土本大介, 作見邦彦, 中別府雄作
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Ogg1, Mth1, Mutyhの3重遺伝子欠損マウス系統のミュテーター・フェノタイプに起因した遺伝性水頭症2008
    • Author(s)
      外間政朗, 大野みずき, 作見邦彦, 佐々木富男, 中別府雄作
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Oxidation of mitochondrial deoxynucleotide pools induces mitochondrial degeneration and cell death.2008
    • Author(s)
      Junji Ichikawa, Daisuke Tsuchimoto, Sugako Oka, Mizuki Ohno, Kunihiko Sakumi, Yusaku Nakabeppu
    • Organizer
      The 7th European Meeting on Mitochondrial Pathology, Stockholm
    • Place of Presentation
      Sweden.
    • Year and Date
      2008-06-12
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 活性酸素によるゲノム障害とその防御機構2008
    • Author(s)
      中別府雄作
    • Organizer
      第3回放射線防護研究センターシンポジウム(独立行政法人放射線医学総合研究所)「生き物はどのようにして放射線に立ち向かうか-DNA損傷応答と適応応答-」
    • Place of Presentation
      千葉
    • Year and Date
      2008-12-16
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.2008
    • Author(s)
      Sugako Oka, Mizuki Ohno, Daisuke Tsuchimoto, Kunihiko Sakumi, Masato Furuichi, Yusaku Nakabeppu
    • Organizer
      The 7th European Meeting on Mitochondrial Pathology, Stockholm
    • Place of Presentation
      Sweden
    • Year and Date
      2008-06-12
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] 8-オキソグアニンは染色体組換えを誘発する2008
    • Author(s)
      大野みずき, 作見邦彦, 中別府雄作
    • Organizer
      がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-22
    • Data Source
      KAKENHI-PROJECT-20013034

  • [Presentation] Defenses against damage in nucleotide pools and suppression ofcarcinogenesis, neurodegeneration and heart failure.2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Organizer
      38thAnnual Meeting of the Environmental Mutagen Society
    • Place of Presentation
      Atlanta, GA, USA
    • Year and Date
      2007-10-22
    • Data Source
      KAKENHI-PROJECT-18013038

  • [Presentation] Cell death caused by 8-oxoguanine2007
    • Author(s)
      Nakabeppu Y.
    • Organizer
      3rd Japan-US DNA Repair Meeting
    • Place of Presentation
      Akiu,Sendai
    • Year and Date
      2007-05-08
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Presentation] Mice that express only DFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity2007
    • Author(s)
      Nakabeppu, Y., et. al.
    • Organizer
      The 30th Annual Meeting of the Canadian College of Neuropsychopharmacology
    • Place of Presentation
      Banff, Alberta, Canada
    • Year and Date
      2007-06-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Presentation] Disruption of Defense Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polynhenols2007
    • Author(s)
      Nakabeppu, Y
    • Organizer
      3rd International Conference on Polyphenol and Health
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-10-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Presentation] Mice that express only ΔFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity2007
    • Author(s)
      Nakabeppu Y., et. al.
    • Organizer
      30th Annual Meeting of the Canadian College of Neurpsychoharmacology(CCNP)
    • Place of Presentation
      Banff,Alberm,Canada
    • Year and Date
      2007-06-10
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Presentation] Mice that express only ΔFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Organizer
      30^<th> Annual Meeting of the Canadian College of Neuropsychopharmacology(CCNP)
    • Place of Presentation
      Banff, Alberta, Canada
    • Year and Date
      2007-06-10
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Presentation] Defenses against damage in nucleotide pools and the suppression of carcinogenesis,neurodegeneration and heart failure.2007
    • Author(s)
      Nakabeppu Y, et. al.
    • Organizer
      38^<th> Annual Meeting of the Environmental Mutagen Society
    • Place of Presentation
      Atlanta, GA, USA
    • Year and Date
      2007-10-22
    • Data Source
      KAKENHI-PROJECT-18300124

  • [Presentation] Disruption of Defbnce Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polyphenols2007
    • Author(s)
      Nakabeppu Y., et. al.
    • Organizer
      3rd International Confbrence on Polyphenol and Health
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-10-25