Seiki Motoharu 清木元治

… Alternative Names

SEIKI Motoharu 清木元治

清水元治セイキモトハル

清木元治

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Researcher Number	10154634
Other IDs
Affiliation (Current)	2022: 金沢大学, 医学系, 協力研究員
Affiliation (based on the past Project Information) *help	2016 – 2018: 金沢大学, 医学系, 特任教授 2012 – 2013: 東京大学, 医科学研究所, 名誉教授 1997 – 2011: UNIVERSITY OF TOKYO,INSTITUTE OF MEDICAL SCIENCE,PROFESSOR, 医科学研究所, 教授 2007: 東大, 医科学研究所, 教授 1989 – 1996: 金沢大学, がん研究所, 教授 … More 1987: (財)癌研究会癌研究所, ウイルス腫瘍部, 主任研究員 1987: 癌研究所, 主任研究員 1987: 癌研究所, ウィルス腫瘍部, 主任研究員 1986: 癌研究所, ウイルス腫瘍部, 主任研究員 1986: 癌研究所, ウイルス腫瘍部, 研究員 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Biological Sciences / Experimental pathology / Tumor biology / 分子遺伝学・分子生理学 / General medical chemistry / General medical chemistry / Tumor biology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator MT1-MMP / マトリックスメタロプロテアーゼ / MMP / 浸潤 / MT-MMP / 浸潤・転移 / がん / 転移 / 浸潤転移 / 膜型酵素 … More / がんの浸潤・転移 / 細胞外基質分解酵素 / 細胞運動 / TIMP / 癌 / GPI / 膜型マトリックスメタロプロテアーゼ / HIF-1 / Mint3 / ゼラチナーゼA / MT4-MMP / ras / HTLV-1 / メタロプロテア-ゼ / NM23 / 転移抑制遺伝子 / 転移・浸潤 / メタロプロテアーゼ / MMP-2 / CD44 / ラミニン / インテグリン / FIH-1 / 腫瘍形成 / コラーゲン / プロテアーゼ / がん細胞 / TIMP-2 / Gelatinase A / Invasion and metastasis / Matrix metalloproteinase / MT5-MMP / 基底膜 / スプライシングの調節 / rex / LTR / AMF / がん悪性化 / NDPキナ-ゼ / βmアクチン / メタロプロテイナーゼ / 転移遺伝子 / Tax / 細胞性初期遺伝子 / c-fos / SRF / ATL / 癌転移 / 細胞外マトリックス分解酵素 / 92-kDa typeIV Collagenase / 72-kDa typeIV Collagenase / EBV / LMP / Src / Rb control element / カルポニン / がん浸潤・転移 / 細胞外マトリックス / マトリックス、メタロプロテアーゼ / 胎盤形成 / 細胞外マトリックス分解 / 膜型メタロプロテアーゼ / 転移関連遺伝子 / 細胞形態変化 / 癌細胞 / 細胞外基質 / MTCBP-1 / ヒアルロン酸 / MMP-7 / CD82 / 腫瘍細胞株 / 可移植性 / 細胞バンク / 遺伝性疾患 / コホート研究 / DNA資料 / 病理解析 / 遺伝子改変マウス / 膜型プロテアーゼ / 腫瘍微小環境 / p27RE-Rho / Rho活性化 / 浸潤突起 / マクロファージ / ラミニン332 / 腫瘍血管新 / 生モノクローナル抗体 / コラーゲン分解 / 腫瘍抑制 / HB-EGF / 増殖 / リン酸化 / ZF21 / p27RF-Rho / HIH-1 / マトッリクスメタロプロテアーゼ / EMT / 乳癌 / MT2-MMP / MT3-MMP / 膜型メタロプロデアーゼ / 乳癌細胞株 / CANCER / INVASON AND METASTASIS / BREAST CARCINOMA / MATRIX METALLOPROTEINASE / マトリックスメタロプロティナーゼ / 膜型マトリックスメタロプロティナーゼ / マウス胎児 / 組織改変 / マトリックスメタロプロテイナーゼ / セラチナーゼA / 組織構築 / マウス発生過程 / トロフォブラスト / Matrix metalloproteinas / Membrane-type matrix metalloproteinase / Mouse embryo / Tissue remodeling / がんの湿潤・転移 / MT-1-MMP / Extracellular matrix / インヒビター / MMP inhibitor / ノックアウトマウス / トランスジェニックマウス / 小脳 / 神経細胞軸策伸長 / 神経分化 / Transgenic mice / Knockout mice / 膜型MMP / 膜蛋白質 / 網羅的プロテオミクス解析 / 浸潤装置 / 細胞接着分子 / Proteolysis / Membrane proteins / proteomics / nano-LC-MS / MS / Membrane-type MMP / Integrins / Menbrane proteins / Proteomic analysis / 肝臓がん / がん幹細胞 / がんの増殖・浸潤・転移 / EpCAM / CD90 / 肝細胞がん / がん微小環境 / EphA2 / HIF / Invasion / 肝臓 / 悪性化 … More Except Principal Investigator ATL / p40^<tax> / Tax / 癌遺伝子 / HTLV-I / 細胞死 / HTLVーI / 転写因子 / 浸潤 / HTLV-1 / がん / シグナル伝達 / 分化 / 浸潤・転移 / 細胞外マトリックス / 細胞増殖 / 成人T細胞白血病 / ヒト白血病ウイルス / がん遺伝子 / がん抑制遺伝子 / がん細胞 / 転写活性化因子 / 母子感染 / HTLVーIキャリア / 転写促進因子 / 機能ドメイン / p27^<rex> / HTLVーIキャリア-ラット / HTLVー1 / cーfos / APー1 / cーjun / HAM / HILV-I感染ラット / トランスアクチベーション / HAMラット / マトリックスメタロプロテネース / MMP-11 / トロフォブラスト / 胎盤 / 子宮 / シバヤギ / マウス / SRF / CArG box / fra-1 / 増殖因子 / 細胞周期 / 細胞運動 / 細胞接着 / 組織 / 増殖 / 細胞極性 / 転移 / 接着 / レトロウイルス / イノシトール燐脂質代謝 / fos遺伝子 / myc遺伝子 / erbβ遺伝子 / pX遺伝子 / HTLV / トランス活性化因子 / 発癌機構 / インターロイキン-2 / HTLV増殖機構 / HTLVワクチン / レトロウィルス / イノシトール燐脂質 / トランスフォーメーショmyc関連遺伝子 / myb関連遺伝子 / ski関連遺伝子 / 転写活性化 / トランス作用 / インターロイキンー2受容体 / 研究情報交換 / ウイルス発がん / 発がんプロモーター / 増殖制御 / 転写調節 / がん研究 / 研究交流 / 北米 / 研究室訪問 / 研究集会 / Information exchange / Oncogene / Tumor virus / Tumor promoter / Tumor suppressor gene / Cancer cells / Growth control / Transcriptional regulation / 細胞分化 / 細胞間相互作用 / がん転移 / ヒトがん / DNA修復 / ヒトゲノム / 2国間共同研究 / cell growth / cell differentiation / apoptosis / signal transduction / cell-cell interaction / cancer metastasis / human cancer / oncogene / tumor suppressor gene Less

Analysis of MT1-MMP-dependent molecular pathways in the diversity and transformation of hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Seiki Motoharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Study of MT1-MMP in cancerPrincipal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
MT1-MMPを介してがん悪性形質を制御するタンパク質の解析Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
がん研究の資材有効保存と利用に関する研究Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Tumor-stroma interaction mediated by proteasesPrincipal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Disorganization of cell and tissue systems in cancer
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
  Osaka University
Analysis of the proteolytic events on cell surface through proteomic approachPrincipal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  University of Tokyo
Research of the physiological functions of membrane-type matrix metalloproteinasesPrincipal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
細胞外基質分解とがん細胞の浸潤制御機構Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
癌細胞表層における細胞外マトリックス分解制御機構の解析Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
がんの生物学的特性に関する研究の総括
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1999 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Activation of matrix metalloproteinases on cell surfacePrincipal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Isolation and analysis of new memnrane-type matrix metalloproteinasesPrincipal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Evaluation of MMP inhibitors for cancer treatmentPrincipal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
がん細胞の転移と浸潤の分子生物学Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kanazawa University
ROLES OF MEMBRANE TYPE MATRIX METALLOPROTEINASE IN BREAST TUMOR METASTASISPrincipal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Experimental pathology
- Research Institution
  UNIVERSITY OF TOKYO
  Kanazawa University
Roles of membrane-type matrix metalloproteinase in tissue organization.Principal Investigator
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kanazawa University
Cooperation and information exchange with European countries.
- Principal Investigator
  
  KUROKI Toshio
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Showa University
  The University of Tokyo
HTLV-I感染細胞の増殖癌化の分子機構
- Principal Investigator
  
  菅村和夫
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
がん細胞の浸潤性獲得の分子機構Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
癌浸潤モデルとしてのトロフォブラストの研究
- Principal Investigator
  
  舘鄰
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
細胞性初期遺伝子群の転写制御因子p67^<SRF>のHTLV-1Taxによる活性化機構
- Principal Investigator
  
  藤井雅寛
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
EBウイルス・LMPを用いての細胞接着を介したシグナル伝達系の解析Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kanazawa University
HTLV-I感染細胞の増殖癌化の分子機構
- Principal Investigator
  
  菅村和夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
がん細胞の浸潤性獲得の分子機構Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
HTLV-1 Taxによる細胞性初期遺伝子の発現誘導機講とウイルス複製への役割Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kanazawa University
HTLVーI感染細胞の増殖癌化の分子機構
- Principal Investigator
  
  菅村和夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
がん細胞の浸潤性獲得の分子機構Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
HTLVー1 Tax蛋白によるcーfos発現誘導の分子機構
- Principal Investigator
  
  藤井雅寛
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
Information Exchange on Cancer Research with North American Countries.
- Principal Investigator
  
  YAMAGUCHI Nobuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute of Medical Science, University of Tokyo
成人T細胞白血病と病因ウイルス
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
癌遺伝子rasによる高転移性獲得過程の分子生物学的解析Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
癌遺伝子rasによる高転移性獲得過程の分子生物学的解析Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
ヒトT細胞白血病ウイルスの遺伝子産物によるプライシングの調節機構Principal Investigator
- Principal Investigator
  
  清木元治
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  分子遺伝学・分子生理学
- Research Institution
  Kanazawa University
レトロウィルスによる発癌機構の研究
- Principal Investigator
  
  河井貞明
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
ヒト白血病ウイルスの遺伝子発現と成人T細胞白血病の発症機構
- Principal Investigator
  
  吉田光昭
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
アメリカ大陸を中心としてがん研究先進グループとの研究交流
- Principal Investigator
  
  河井貞明
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Overseas Scientific Research
- Research Institution
  The University of Tokyo
レトロウイルスによる発癌機構の研究
- Principal Investigator
  
  河井貞明
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
ヒト白血病ウイルスの発癌機構および感染の診断・予防に関する基礎的研究
- Principal Investigator
  
  YOSHIDA Mituaki
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Japanese Foundation For Cancer Research

[Book] がん基盤生物学-革新的シーズ育成に向けて-2013
- Author(s)
  清木元治(総編集)
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-22220014
[Book] がんの浸潤・転移第20章細胞外マトリックス(ECM)2011
- Author(s)
  坂本毅治, 清木元治
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-22220014
[Book] 「がん生物学」分担項目:細胞運動と浸潤2011
- Author(s)
  星野大輔、長野真、清木元治
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Unique Biological Activity and Potential Role of Monomeric Laminin-γ2 as a Novel Biomarker for Hepatocellular Carcinoma2019
- Author(s)
  Yasuda H, Nakagawa M, Kiyokawa H, Yoshida E, Yoshimura T, Koshikawa N, Itoh F, Seiki M
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 1 Pages: 226-226
- DOI
  10.3390/ijms20010226
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08655, KAKENHI-PLANNED-17H06329, KAKENHI-PROJECT-16H04695, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K09027
[Journal Article] Simple and cost-effective assay for isolating invasive living cells2018
- Author(s)
  Takino Takahisa、Sato Hiroshi、Seiki Motoharu
- Journal Title
  
  BioTechniques
  
  Volume: 65 Pages: 137-142
- DOI
  10.2144/btn-2018-0036
- NAID
  120006605145
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04695
[Journal Article] Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells2018
- Author(s)
  Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M & Koshikawa N
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1731 Pages: 29-37
- DOI
  10.1007/978-1-4939-7595-2_3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K09027, KAKENHI-PLANNED-17H06329, KAKENHI-PROJECT-16H04695
[Journal Article] Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes2017
- Author(s)
  Hara T, Nakaoka HJ, Hayashi T, Mimura K, Hoshino D, Inoue M, Nagamura F, Murakami Y, Seiki M, Sakamoto T.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 114
- DOI
  10.1073/pnas.1703171114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06829, KAKENHI-PROJECT-17K08904, KAKENHI-PROJECT-16H04695
[Journal Article] Specific detection of soluble EphA2 fragments in blood as a new biomarker for pancreatic cancer2017
- Author(s)
  Koshikawa Naohiko、Minegishi Tomoko、Kiyokawa Hirofumi、Seiki Motoharu
- Journal Title
  
  Cell Death and Disease
  
  Volume: 8
- DOI
  10.1038/cddis.2017.545
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09027, KAKENHI-PROJECT-16H04695, KAKENHI-PLANNED-17H06329
[Journal Article] Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo2017
- Author(s)
  Blanco, M. J. Rodriguez-Martin, I. Learte, A. I. R. Clemente, C. Montalvo, M. G. Seiki, M. Arroyo, A. G. Sanchez-Camacho, C.
- Journal Title
  
  PLos One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0184767
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04695
[Journal Article] NECAB3 promotes activation of hypoxia-inducible factor-1 during normoxia and enhances tumourigenicity of cancer cells.2016
- Author(s)
  1.Nakaoka HJ, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, Sato H, Murakami Y, Seiki M, Sakamoto T
- Journal Title
  
  Scientific Reports,
  
  Volume: 6 Pages: 0-0
- DOI
  10.1038/srep22784
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06829, KAKENHI-PROJECT-15K12139, KAKENHI-PROJECT-24591313, KAKENHI-PROJECT-25460382, KAKENHI-PROJECT-26640121, KAKENHI-PROJECT-25730173, KAKENHI-PROJECT-25290051, KAKENHI-PUBLICLY-16H01572, KAKENHI-PROJECT-15H05325, KAKENHI-PROJECT-16H04695
[Journal Article] Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage hyperactivation mediated by the influenza virus.2016
- Author(s)
  Uematsu T, Fujita T, Nakaoka HJ, Hara T, Kobayashi N, Murakami Y, Seiki M, Sakamoto T
- Journal Title
  
  Scientific Report
  
  Volume: 6 Pages: 37815-37815
- DOI
  10.1038/srep37815
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06829, KAKENHI-PROJECT-16K09585, KAKENHI-PROJECT-16H04695
[Journal Article] Cortactin promotes exosome secretion by controlling branched actin dynamics.2016
- Author(s)
  Sinha S, Hoshino D, Hong NH, Kirkbride KC, Grega-Larson NE, Seiki M, Tyska MJ, Weaver AM.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 214 Pages: 197-197
- DOI
  10.1083/jcb.201601025
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04695
[Journal Article] The ERK signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux.2016
- Author(s)
  Yoshino S, Hara T, Nakaoka HJ, Kanamori A, Murakami Y, Seiki M, Sakamoto T.
- Journal Title
  
  Cell Discovery
  
  Volume: 2 Pages: 16019-16019
- DOI
  10.1038/celldisc.2016.19
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06829, KAKENHI-PROJECT-16H04695
[Journal Article] Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP2014
- Author(s)
  Sakamoto, T., Weng, J. S., Hara, T., Yoshino, S., Kozuka-Hata, H., Oyama, M., and Seiki, M
- Journal Title
  
  Mol Cell Biol
  
  Volume: 34(1) Pages: 30-42
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] HIF-1 regulation through crosstalk between mTOR and MT1-MMP.2014
- Author(s)
  Sakamoto T, Weng JS, Hara T, Yoshino S, Kozuka-Hata H, Oyama M, Seiki M.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 34(1) Pages: 30-42
- DOI
  10.1128/mcb.01169-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-23510254, KAKENHI-PROJECT-24591313
[Journal Article] Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix.2014
- Author(s)
  Weaver SA, Wolters B, Ito N, Woskowicz AM, Kaneko K, Shitomi Y, Seiki M, Itoh Y.
- Journal Title
  
  J Cell Sci.
  
  Volume: 127(Pt6) Pages: 1203-13
- DOI
  10.1242/jcs.135236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.2013
- Author(s)
  Nagano M, Hoshino D, Koshiba S, Shuo T Koshikawa N, Tomizawa T, Hayashi F, Tochio N, Harada T, Akizawa T Watanabe S, Handa N, Shirouzu M, Kigawa T, Yokoyama S, Seiki M
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286(36) Pages: 1598-31609
- DOI
  10.1074/jbc.m110.199430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PROJECT-22700375, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23790109
[Journal Article] Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia.2013
- Author(s)
  Watanabe A, Hoshino D, Koshikawa N, Seiki M, Suzuki T, Ichikawa K.
- Journal Title
  
  PLoS Comput Biol.
  
  Volume: 9(5)
- DOI
  10.1371/journal.pcbi.1003086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05013, KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-25462471
[Journal Article] Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β12013
- Author(s)
  Mori, H., Lo, A. T., Inman, J. L., Alcaraz, J., Ghajar, C. M., Mott, J. D., Nelson, C. M., Chen, C. S., Zhang, H., Bascom, J. L., Seiki, M., and Bissell, M. J
- Journal Title
  
  Development
  
  Volume: 140(2) Pages: 343-52
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] The Phosphoinositide-Binding Protein ZF21 Regulates ECM Degradation by Invadopodia2013
- Author(s)
  Hoshino D, Nagano M, Saitoh A, Koshikawa N, Suzuki T, Seiki M.
- Journal Title
  
  PLoS One
  
  Volume: 8(1) Pages: 1-8
- DOI
  10.1371/journal.pone.0050825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23790109, KAKENHI-PROJECT-25462471
[Journal Article] CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells2013
- Author(s)
  Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, Sakai R.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 11(6) Pages: 628-37
- DOI
  10.1158/1541-7786.mcr-12-0544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-24501327, KAKENHI-PROJECT-25430126
[Journal Article] The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia2013
- Author(s)
  Hoshino, D., Nagano, M., Saitoh, A., Koshikawa, N., Suzuki, T., and Seiki, M
- Journal Title
  
  PLos One
  
  Volume: 8(1)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] MT1-MMP-dependent control of skeletal stem cell commitment via a beta 1-integrin/YAP/TAZ signaling axis2013
- Author(s)
  Tang, Y., Rowe, R. G., Botvinick, E. L., Kurup, A., Putnam, A. J., Seiki, M., Weaver, V. M., Keller, E. T., Goldstein, S., Dai, J., Begun, D., Saunders, T., and Weiss, S. J
- Journal Title
  
  Dev Cell
  
  Volume: 25(4) Pages: 402-16
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.2013
- Author(s)
  Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ.
- Journal Title
  
  Dev Cell.
  
  Volume: 25(4) Pages: 402-16
- DOI
  10.1016/j.devcel.2013.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis2013
- Author(s)
  Hoshiko, S., Kawaguchi, M., Fukushima, T., Haruyama, Y., Yorita, K., Tanaka, H., Seiki, M., Inatsu, H., Kitamura, K., and Kataoka, H
- Journal Title
  
  Cancer Res
  
  Volume: 73(8) Pages: 2659-70
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Hepatocyte growth factor activator inhibitor type 1 (Hai-1/Spint1) is a suppressor of intestinal tumorigenesis2013
- Author(s)
  Hoshiko S, Kawaguchi M, Fukushima T, Haruyama Y, Yorita K, Tanaka H, Seiki M, Inatsu H, Kitamura K, Kataoka H.
- Journal Title
  
  Cancer Res
  
  Volume: 73(8) Pages: 2659-2670
- DOI
  10.1158/0008-5472.can-12-3337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-24390099, KAKENHI-PROJECT-24590419, KAKENHI-PROJECT-24590486
[Journal Article] Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia2013
- Author(s)
  Watanabe, A., Hoshino, D., Koshikawa, N., Seiki, M., Suzuki, T., and Ichikawa, K
- Journal Title
  
  PLos Comput Biol
  
  Volume: 9(5)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Control and inhibition analysis of complex formation processes2012
- Author(s)
  Saitou, T., Itano, K., Hoshino, D., Koshikawa, N., Seiki, M., Ichikawa, K., and Suzuki, T
- Journal Title
  
  Theor Biol Med Model
  
  Volume: 9 Pages: 33-33
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Genetic screening of new genes responsible for cellular adaptation to hypoxia using a genome-wide shRNA library.2012
- Author(s)
  Yoshino S, Hara T, Weng JS, Takahashi Y, Seiki M, Sakamoto T.
- Journal Title
  
  PLoS One
  
  Volume: 7(4)
- DOI
  10.1371/journal.pone.0035590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-24591313, KAKENHI-PUBLICLY-23112505
[Journal Article] Identification of proteins that associate with integrin alpha2 by proteomic analysis in human fibrosarcoma HT-1080 cells2012
- Author(s)
  Uematsu, T., C. Konishi, D. Hoshino, X. Han, Taizotomari, N. Egawa, Y. Takada, T. Isobe, M. Seiki, and N. Koshikawa
- Journal Title
  
  J Cell Physiol
  
  Volume: 8 Pages: 3072-9
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis.2012
- Author(s)
  Hoshino D, Jourquin J, Emmons SW, Miller T, Goldgof M, Costello K, Tyson DR, Brown B, Lu Y, Prasad NK, Zhang B, Mills GB, Yarbrough WG, Quaranta V, Seiki M, Weaver AM.
- Journal Title
  
  Sci Signal.
  
  Volume: 5(241)
- DOI
  10.1126/scisignal.2002964
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects2012
- Author(s)
  Host, L., Paye, A., Detry, B., Blacher, S., Munaut, C., Foidart, J. M., Seiki, M., Sounni, N. E., and Noel, A
- Journal Title
  
  Int. J Cancer
  
  Volume: 131(7) Pages: 1537-48
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCalpha invasive signaling axis2012
- Author(s)
  Hoshino, D., Jourquin, J., Emmons, S. W., Miller, T., Goldgof, M., Costello, K.Tyson, D. R., Brown, B., Lu, Y., Prasad, N. K., Zhang, B., Mills, G. B., Yarbrough, W. G., Quaranta, V., Seiki, M., and Weaver, A. M
- Journal Title
  
  Sci Signal
  
  Volume: 5(241)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Mathematical modeling of invadopodia formation.2012
- Author(s)
  T.Saitou, M.Rouzimaimaiti, N.Koshikawa, M.Seiki, K.Ichikawa, T.Suzuki
- Journal Title
  
  J Theor Biol
  
  Volume: 298 Pages: 138-146
- DOI
  10.1016/j.jtbi.2011.12.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20340034, KAKENHI-PLANNED-22117008, KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PUBLICLY-23117507
[Journal Article] Control and Inhibition Analysis of Complex Formation Processes2012
- Author(s)
  Saitou T, Itano K, Hoshino D, Koshikawa N, Seiki M, Ichikawa K, Suzuki T.
- Journal Title
  
  Theoretical Biology and Medical Modeling
  
  Volume: 3 Pages: 33-33
- DOI
  10.1186/1742-4682-9-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PUBLICLY-23117507, KAKENHI-PLANNED-22117008
[Journal Article] Detection of the heterogeneous O-glycosylation profile of MT1-MMP expressed in cancer cells by a simple MALDI-MS method2012
- Author(s)
  Shuo, T., Koshikawa, N., Hoshino, D., Minegishi, T., Ao-Kondo, H., Oyama, M., Sekiya, S., Iwamoto, S., Tanaka, K., and Seiki, M
- Journal Title
  
  PLos One
  
  Volume: 7(8)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues.2012
- Author(s)
  Mori H, Borowsky AD, Bhat R, Ghajar CM, Seiki M, Bissell MJ.
- Journal Title
  
  Am J Pathol.
  
  Volume: 180(6) Pages: 2249-56
- DOI
  10.1016/j.ajpath.2012.02.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies2012
- Author(s)
  Hoshino, D., N. Koshikawa, T . Suzuki, V . Quaranta, A. Weaver, M. Seiki and K. Ichikawa
- Journal Title
  
  PLos Computational Biology
  
  Volume: 8(4)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies.2012
- Author(s)
  Hoshino, D., Koshikawa, N., Suzuki, T., Quaranta, V., Weaver, A.M., (Seiki, M.), Ichikawa, K.
- Journal Title
  
  PLoS Comput Biol.
  
  Volume: 8
- DOI
  10.1371/journal.pcbi.1002479
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117008, KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PUBLICLY-23117507
[Journal Article] Turnover of focal adhesions and cancer cell migration2012
- Author(s)
  Nagano M, Hoshino D, Koshikawa N, Akizawa T, Seiki M.
- Journal Title
  
  Int J Cell Biol
  
  Volume: 2012 Pages: 1-10
- DOI
  10.1155/2012/310616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23790109
[Journal Article] The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects.2012
- Author(s)
  Host L, Paye A, Detry B, Blacher S, Munaut C, Foidart JM, Seiki M, Sounni NE, Noel A.
- Journal Title
  
  Int J Cancer
  
  Volume: 131(7) Pages: 1537-48
- DOI
  10.1002/ijc.27436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells2012
- Author(s)
  Nishida, C., Kusubata, K., Tashiro, Y., Gritli, I., Sato, A., Ohki-Koizumi, M., Morita, Y., Nagano, M., Sakamoto, T., Koshikawa, N., Kuchimaru, T., Kizaka-Kondoh, S., Seiki, M., Nakauchi, H., Heissig, B., and Hattori, K
- Journal Title
  
  Blood
  
  Volume: 119(23) Pages: 5405-16
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1.2012
- Author(s)
  Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell MJ.
- Journal Title
  
  Development
  
  Volume: 140(2) Pages: 343-52
- DOI
  10.1242/dev.084236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Turnover of focal adhesions and cancer cell migration2012
- Author(s)
  Nagano, M., D. Hoshino, N. Koshikawa, T. Akizawa, and M. Seiki
- Journal Title
  
  Int J Cell Biol
  
  Volume: 2012 Pages: 310616-310616
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase2011
- Author(s)
  Sakamoto T, Niiya D, Seiki M
- Journal Title
  
  J Biol Chem
  
  Volume: J Biol Chem 22;286(16) Pages: 14691-704
- DOI
  10.1074/jbc.m110.188714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22790846, KAKENHI-PUBLICLY-23112505
[Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells2011
- Author(s)
  越川直彦、清木元治, 9/9番目
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 111-6
- NAID
  10029288679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion.2011
- Author(s)
  Hamasaki H, Koga K, Aoki M, Hamasaki M, Koshikawa N, Seiki M, Iwasaki H, Nakayama J, Nabeshima K
- Journal Title
  
  Br J Cancer
  
  Volume: 6;105(6) Pages: 824-32
- DOI
  10.1038/bjc.2011.283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23590419
[Journal Article] Deletion of the Mint3/Apba3 gene in mice abrogates macrophage fun ctions and increases resistance to lipopolysaccharide-induced septic shock2011
- Author(s)
  Hara T, Mimura K, Abe T, Shioi G, Seiki M, Sakamoto T.
- Journal Title
  
  J Biol Chem
  
  Volume: 16;286(37) Pages: 32542-51
- DOI
  10.1074/jbc.m111.271726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22790846, KAKENHI-PUBLICLY-23112505
[Journal Article] Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion2011
- Author(s)
  Hara T, Mimura K, Seiki M, Sakamoto T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 23;413(2) Pages: 277-81
- DOI
  10.1016/j.bbrc.2011.08.085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22790846, KAKENHI-PUBLICLY-23112505
[Journal Article] Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer.2011
- Author(s)
  Itoh Y, Palmisano R, Anilkumar N, Nagase H, Miyawaki A, Seiki M.
- Journal Title
  
  Biochem J.
  
  Volume: 15;440(3) Pages: 319-26
- DOI
  10.1042/bj20110424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells2011
- Author(s)
  Koshikawa, N., H. Mizushima, T. Minegishi, F. Eguchi, F. Yotsumoto, K. Nabeshima, S. Miyamoto, E. Mekada, and M. Seiki
- Journal Title
  
  Cancer Sci
  
  Volume: 102(1) Pages: 111-6
- NAID
  10029288679
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC2011
- Author(s)
  星野大介、清木元治, 3/3番目
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 3139-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion2011
- Author(s)
  Hara, T., K. Mimura, M. Seiki, and T. Sakamoto
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 413(2) Pages: 277-81
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock2011
- Author(s)
  Hara, T., K. Mimura, T. Abe, G. Shioi, M. Seiki, and T. Sakamoto
- Journal Title
  
  J Biol Chem
  
  Volume: 286(37) Pages: 32542-51
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC2011
- Author(s)
  Hoshino, D., N. Koshikawa, and M. Seiki
- Journal Title
  
  J Biol Chem
  
  Volume: 286(4) Pages: 3139-48
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer2011
- Author(s)
  Itoh, Y., R. Palmisano, N. Anilkumar, H. Nagase, A. Miyawaki, and M. Seiki
- Journal Title
  
  Biochem J
  
  Volume: 440(3) Pages: 319-26
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells2011
- Author(s)
  Shirakabe K, Hattori S, Seiki M. Koyasu S, Okada Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 16;286(50) Pages: 43154-43163
- DOI
  10.1074/jbc.m111.275586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-23510261
[Journal Article] ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center2011
- Author(s)
  Nagano, M., D. Hoshino, T. Sakamoto, T. Akizawa, N. Koshikawa, and M. Seiki
- Journal Title
  
  Cell Adh Migr
  
  Volume: 5(1) Pages: 23-8
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Synthetic emmprin peptides inhibit tumor cell-fibroblast interaction-stimulated upregulation of MMP-2 and tumor cell invasion.2011
- Author(s)
  Koga K, Aoki M, Sameshima T, Hamasaki M, Egawa N, Seiki M, Toole BP, Suzumiya J, Nabeshima K.
- Journal Title
  
  INTERNATIONAL JOURNAL OF ONCOLOGY
  
  Volume: 39(3) Pages: 657-64
- DOI
  10.3892/ijo.2011.1060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-23791303
[Journal Article] Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase2011
- Author(s)
  Sakamoto, T., D. Niiya, and M. Seiki
- Journal Title
  
  J Biol Chem
  
  Volume: 286(16) Pages: 14691-704
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water bomeostasis in mice2011
- Author(s)
  Srichai MB、清木元治, 7/10番目
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mecha nism2010
- Author(s)
  Sakamoto, T. and M. Seiki
- Journal Title
  
  J Biol Chem
  
  Volume: 285(39) Pages: 29951-64
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism2010
- Author(s)
  坂本毅治、清木元治, 2/2番目
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 29951-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center2010
- Author(s)
  長野真、清木元治, 6/6番目
- Journal Title
  
  Cell Adh Migr.
  
  Volume: 5 Pages: 23-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] ZF21 protein regulates cell adhesion and motility2010
- Author(s)
  Nagano, M., D. Hoshino, T. Sakamoto, N. Kawasaki, N. Koshikawa, and M. Seiki
- Journal Title
  
  J Biol Chem
  
  Volume: 285(27) Pages: 21013-22
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor2010
- Author(s)
  Koshikawa, N., H. Mizushima, T. Minegishi, R. Iwamoto, E. Mekada, and M. Seiki
- Journal Title
  
  Cancer Res
  
  Volume: 70(14) Pages: 6093-103
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor2010
- Author(s)
  越川直彦、清木元治, 6/6番目
- Journal Title
  
  Cancer Res
  
  Volume: 70 Pages: 6093-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] ZF21 protein regulates cell adhesion and motility2010
- Author(s)
  長野真、清木元治, 6/6番目
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 21013-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain2010
- Author(s)
  Nagano, M., D. Hoshino, S. Koshiba, T. Shuo, N. Koshikawa, T. Tomizawa, F. Hayashi, N. Tochio, T. Harada, T. Akizawa, S. Watanabe, N. Handa, M. Shirouzu, T. Kigawa, S. Yokoyama, and M. Seiki
- Journal Title
  
  J Biol Chem
  
  Volume: 286(36) Pages: 31598-609
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice2010
- Author(s)
  Onozuka I、清木元治, 12/14番目
- Journal Title
  
  BBRC
  
  Volume: 406 Pages: 134-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP) : asystemic whole cell analysis of MT1-MMP-associating proteins in A431 cells.2009
- Author(s)
  Niiya, D., N.Egawa, T.Sakamoto, Y.Kikkawa, T.Shinkawa, T.Isobe, N.Koshikawa, M.Seiki.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 27360-27369
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] High throughput analysis of proteins associating with a proinvasive MT1-MMP in human malignant melanoma A375 cells.2009
- Author(s)
  Tomari, T., N.Koshikawa, T.Uematsu, T.Shinkawa, D.Hoshino, N.Egawa, T.Isobe, M.Seiki.
- Journal Title
  
  Cancer Sci 100
  
  Pages: 1284-1290
- NAID
  10027192295
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27 (kip1) and regulates RhoA activation, actinremodeling, and matrigel invasion.2009
- Author(s)
  Hoshino, D., T.Tomari, M.Nagano, N.Koshikawa, M.Seiki.
- Journal Title
  
  J BiolChem 284
  
  Pages: 27315-27326
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Mint3enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1.2009
- Author(s)
  Sakamoto, T., M.Seiki.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 30350-30359
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Mint3 enhances the activity of hypoxia-inducible factor-1(HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-12009
- Author(s)
  坂本、清木
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 30350-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27kip1 and regulates RhoA activation, actin remodeling, and Matrigel invasion.2009
- Author(s)
  Hoshino D, Tomari T, Nagano M, Koshikawa N, Seiki M.
- Journal Title
  
  J Biol Chem. 284(40)
  
  Pages: 27315-27326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16060101
[Journal Article] Spontaneous transformation of human granulosa cell tumours into an aggressive henotype : a metastasis model cell line.2008
- Author(s)
  Imai, M., M.Muraki, K.Takamatsu, H.Saito, M.Seiki, Y.Takahashi.
- Journal Title
  
  BMC Cancer 8
  
  Pages: 319-319
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Development of a new tracking tool for the human monomeric laminin-gamma 2 chain in vitro and in vivo2008
- Author(s)
  Koshikawa, N., Seiki, M., (他2名)
- Journal Title
  
  Cancer Research 68
  
  Pages: 530-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] The second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface.2008
- Author(s)
  Itoh, Y., N.Ito, H.Nagase, M.Seiki.
- Journal Title
  
  J Biol Chem 283
  
  Pages: 13053-13062
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] he second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface.2008
- Author(s)
  Itoh Y, Ito N, Nagase H, Seiki M.
- Journal Title
  
  J Biol Chem. 283(19)
  
  Pages: 13053-13062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16060101
[Journal Article] Development of a new tracking tool for the human monomeric laminin-gamma 2 chain in vitro and in vivo.2008
- Author(s)
  Koshikawa, N., T.Minegishi, K.Nabeshima, M.Seiki.
- Journal Title
  
  Cancer Res 68
  
  Pages: 530-536
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase.2007
- Author(s)
  Rikimaru, A., K.Komori, T.Sakamoto, H.Ichise, N.Yoshida, I.Yana, M.Seiki.
- Journal Title
  
  Genes Cells 12
  
  Pages: 1091-1100
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.2007
- Author(s)
  Taniwaki, K., H.Fukamachi, K.Komori, Y.Ohtake, T.Nonaka, T.Sakamoto, T.Shiomi, Y.Okada, T.Itoh, S.Itohara, M.Seiki, I.Yana.
- Journal Title
  
  Cancer Res 67
  
  Pages: 4311-4319
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells2007
- Author(s)
  Yana, I., Seiki, M. (他10名)
- Journal Title
  
  J Cell Sci 120
  
  Pages: 1607-1614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17012003
[Journal Article] Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells.2007
- Author(s)
  Yana, I., H.Sagara, S.Takaki, K.Takatsu, K.Nakamura, K. Nakao, M.Katsuki, S.Taniguchi, T.Aoki, H.Sato, S.J.Weiss, M.Seiki.
- Journal Title
  
  J Cell Sci 120
  
  Pages: 1607-1614
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase.2007
- Author(s)
  Rikimaru, A.., Seiki, M., (他5名)
- Journal Title
  
  Cancer Research 12
  
  Pages: 1091-1100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice2007
- Author(s)
  Taniwaki, K., Seiki, M., (他10名)
- Journal Title
  
  Cancer Research 67
  
  Pages: 4311-4319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice2007
- Author(s)
  Taniwaki, K., Seiki, M. (他10名)
- Journal Title
  
  Cancer Research 67
  
  Pages: 4311-4319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17012003
[Journal Article] Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells2007
- Author(s)
  Yana, I., Seiki, M., (他10名)
- Journal Title
  
  J Cell Sci 120
  
  Pages: 1607-1614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Regulated nucleo-cytoplasmic shuttling of human aci-reductone dioxygenase (hADI1) and its potential role in mRNA processing.2007
- Author(s)
  Gotoh, I., T.Uekita, M.Seiki.
- Journal Title
  
  Genes Cells 12
  
  Pages: 105-117
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Multifunctional roles of MT1-MMP in myofiber formation and morphostatic maintenance of skeletal muscle.2006
- Author(s)
  Ohtake, Y., H.Tojo, M.Seiki.
- Journal Title
  
  J Cell Sci 119
  
  Pages: 3822-3832
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.2006
- Author(s)
  Egawa, N., N.Koshikawa, T.Tomari, K.Nabeshima, T.Isobe, M.Seiki.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 37576-37585
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] MT1-MMP : a potent modifier of pericellular microenvironment.2006
- Author(s)
  Itoh, Y.M.Seiki.
- Journal Title
  
  J Cell Physiol 206
  
  Pages: 1-8
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] MT1-MMP : a potent modifier of pericellular microenvironment2006
- Author(s)
  Itoh, Y., Seiki, M.
- Journal Title
  
  J Cell Physiol 1
  
  Pages: 1-8
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP.2006
- Author(s)
  Itoh, Y., N.Ito, H.Nagase, R.D.Evans, S.A.Bird, M.Seiki.
- Journal Title
  
  Mol Biol Cell 17
  
  Pages: 5390-5399
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand.2006
- Author(s)
  Hikita, A., I.Yana, H.Wakeyama, M.Nakamura, Y.Kadono, Y.Oshima, K.Nakamura, M.Seiki, S.Tanaka.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 36846-36855
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration.2006
- Author(s)
  Takino, T., Y.Watanabe, M.Matsui, H.Miyamori, T.Kudo, M.Seiki, H.Sato.
- Journal Title
  
  Exp Cell Res 312
  
  Pages: 1381-1389
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Type I collagen abrogates the clathrin-mediated internalization of membrane type 1 matrixmetalloproteinase (MT1-MMP) via the MT1-MMP hemopexin domain.2006
- Author(s)
  Lafleur, M.A., F.A. Mercuri, N.Ruangpanit, M.Seiki, H.Sato, E.W.Thompson.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 6826-6840
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP)2005
- Author(s)
  Irie, K, Seiki, M, 他5名
- Journal Title
  
  Med Mol Morphol 38・1
  
  Pages: 43-6
- NAID
  10018374513
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Palmitoyalion at Cys574 is essential for MT1-MMP to promote cell migration2005
- Author(s)
  Anilkumar, N, Seiki M, 他4名
- Journal Title
  
  FASEB J 19・10
  
  Pages: 1326-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] CC44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase2005
- Author(s)
  Suenaga, N., Seiki, M., 他2名
- Journal Title
  
  Oncogene 24・5
  
  Pages: 859-868
- Data Source
  KAKENHI-PROJECT-17012003
[Journal Article] CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase2005
- Author(s)
  Suenaga, N., Seiki, M.(two others).
- Journal Title
  
  Oncogene Vol.24, No.5
  
  Pages: 859-868
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo2005
- Author(s)
  Nonaka, T., Seiki, M.(three others).
- Journal Title
  
  Mol.Can.Ther. Vol.4, No.8
  
  Pages: 1157-1166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration.2005
- Author(s)
  Anilkumar, N., T.Uekita, J.R.Couchman, H.Nagase, M.Seiki, Y.Itoh.
- Journal Title
  
  Faseb J 19
  
  Pages: 1326-1328
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase.2005
- Author(s)
  Suenaga, N., H.Mori, Y.Itoh, M.Seiki.
- Journal Title
  
  Oncogene 24
  
  Pages: 859-868
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP).2005
- Author(s)
  Irie, K., K.Komori, M.Seiki, E.Tsuruga, Y.Sakakura, T.Kaku, T.Yajima.
- Journal Title
  
  Med Mol Morphol 38
  
  Pages: 43-46
- NAID
  10018374513
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Matrix metalloproteinase expression and function during fin regeneration in zebrafish : analysis of MT1-MMP, MMP2 and TIMP22005
- Author(s)
  Bai, S., Seiki, M.(eight others).
- Journal Title
  
  Matrix Biol. Vol.24, No.4
  
  Pages: 247-260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain.2005
- Author(s)
  Koshikawa, N., T.Minegishi, A.Sharabi, V.Quaranta, M.Seiki.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 88-93
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo2005
- Author(s)
  NoNaka, T, Yana, I, Seiki, M
- Journal Title
  
  Mol Cancer Ther 4・8
  
  Pages: 1157-66
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase ARD) in the methionine salvage pathway.2005
- Author(s)
  Hirano, W., I.Gotoh, T.Uekita, M.Seiki.
- Journal Title
  
  Genes Cells 10
  
  Pages: 565-574
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Matrix metalloproteinase expression and function during fin regeneration in zebrafish : analysis of MT1-MMP, MMP2 and TIMP22005
- Author(s)
  Bai, S, Seiki, M, 他8名
- Journal Title
  
  Matrix Biol 24・4
  
  Pages: 247-60
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Membrane-type 1 matrix metalloproteinase cytopiasmic tail binding protein-1(MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway2005
- Author(s)
  Hirano, W., Seiki, M., 他2名
- Journal Title
  
  Genes Cells 10・6
  
  Pages: 565-574
- Data Source
  KAKENHI-PROJECT-17012003
[Journal Article] Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration2005
- Author(s)
  Anikumar, N, Seiki, M(four others).
- Journal Title
  
  FASEB J Vol.19, No.19
  
  Pages: 1326-1328
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Jr.Matrix metalloproteinase expression and function during fin regeneration in zebrafish : analysis of MT1-MMP, MMP2 and TIMP2.2005
- Author(s)
  Bai, S., R.Thummel, A.R.Godwin, H.Nagase, Y.Itoh, L.Li, R.Evans, J.McDermott, M.Seiki, M.P.Sarras
- Journal Title
  
  Matrix Biol 24
  
  Pages: 247-260
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain2005
- Author(s)
  Koshikawa, N., Seiki, M.(three others).
- Journal Title
  
  J.Biol.Chem. Vol.280, No.1
  
  Pages: 88-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP)2005
- Author(s)
  Irie, K., Seiki, M.(five others).
- Journal Title
  
  Med.Mol.Morphol. Vol.38, No.1
  
  Pages: 43-46
- NAID
  10018374513
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.2005
- Author(s)
  Nonaka, T., K.Nishibashi, Y.Itoh, I.Yana, M.Seiki.
- Journal Title
  
  Mol Cancer Ther 4
  
  Pages: 1157-1166
- Data Source
  KAKENHI-PROJECT-17014019
[Journal Article] Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain2005
- Author(s)
  Koshikawa, N, Seiki, M, 他3名
- Journal Title
  
  J Biol Chem. 280・1
  
  Pages: 88-93
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] CD44 binding through the hemopexin-like domain is criticat for its shedding by membrane-type 1 matrix metalloproteinase2005
- Author(s)
  Suenaga, N, Seiki, M, 他2名
- Journal Title
  
  Oncogene 24・5
  
  Pages: 859-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209011
[Journal Article] Genetic screening of new genes responsible for cellular adaptation to hypoxia using a genome-wide shRNA library
- Author(s)
  Yoshino, S., T . Hara, J. S. Weng, Y . Takahashi, M. Seiki, and T . Sakamoto
- Journal Title
  
  PLos One
  
  Volume: 7(4)
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] EphA2 N末端フラグメント抗体2018
- Inventor(s)
  越川直彦、清木元治
- Industrial Property Rights Holder
  国立大学法人東京大学、神奈川県立病院機構
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-534429
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16H04695
[Patent] 生体組織から線維芽細胞を単離する方法およびそれに用いるキット2017
- Inventor(s)
  滝野隆久、遠藤良夫、二宮致、清木元治
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H04695
[Patent] がんの検査方法及び検査用キット2014
- Inventor(s)
  清木元治、越川直彦
- Industrial Property Rights Holder
  清木元治、越川直彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-026026
- Filing Date
  2014-02-13
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] がんの検査方法及び検査用キット2014
- Inventor(s)
  清木元治, 越川直彦
- Industrial Property Rights Holder
  清木元治, 越川直彦
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-13
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] がんの検査方法及び検査用キット2014
- Inventor(s)
  清木元治, 越川直彦
- Industrial Property Rights Holder
  清木元治, 越川直彦
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-13
- Overseas
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] がんの検査方法及び検査用キット2014
- Inventor(s)
  清木元治、越川直彦
- Industrial Property Rights Holder
  清木元治、越川直彦
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-13
- Overseas
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] 同一試料中の2種の物質を検出又は測定する方法2013
- Inventor(s)
  清木元治, 越川直彦
- Industrial Property Rights Holder
  清木元治, 越川直彦
- Industrial Property Rights Type
  特許
- Filing Date
  2013-07-05
- Overseas
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] METHODS OF PROGNOSIS AND DIAGNOSIS FOR CANCER2012
- Inventor(s)
  清木元治,越川直彦,中川将利,吉田栄作,吉村徹
- Industrial Property Rights Holder
  清木元治,越川直彦,中川将利,吉田栄作,吉村徹
- Industrial Property Rights Type
  特許
- Filing Date
  2012-08-13
- Overseas
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] METHODS OF PROGNOSIS AND DIAGNOSIS FOR CANCER2012
- Inventor(s)
  清木元治, 越川直彦, 中川将利, 吉田栄作, 吉村徹
- Industrial Property Rights Holder
  清木元治, 越川直彦, 中川将利, 吉田栄作, 吉村徹
- Industrial Property Rights Type
  特許
- Filing Date
  2012-08-13
- Overseas
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] 同一試料中の２種の物質を検出又は測定する方法2012
- Inventor(s)
  清木元治、越川直彦
- Industrial Property Rights Holder
  清木元治、越川直彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-151610
- Filing Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] 泌尿器科がんの検査方法および検査用キット2011
- Inventor(s)
  清木元治, 越川直彦, 執印太朗, 鎌田雅行
- Industrial Property Rights Holder
  清木元治, 越川直彦, 執印太朗, 鎌田雅行
- Industrial Property Rights Type
  特許
- Filing Date
  2011-03-08
- Data Source
  KAKENHI-PROJECT-22220014
[Patent] 泌尿器科がんの検査方法及び検査用キット2010
- Inventor(s)
  清木元治、越川直彦、執印太郎、鎌田雅之
- Industrial Property Rights Holder
  東京大学、高知大学
- Filing Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-17014019
[Patent] MT1-MMP,iFIH, FIH-1 によるHIF-1 の制御2008
- Inventor(s)
  清木元治、坂本毅治
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] 5.RNA exosome component EXOSC9 is indispensable for stress resistance in breast cancer.2019
- Author(s)
  Seiko Yoshino, Yuya Fukui, Yusuke Matsui, Motoharu Seiki, Yoshinori Murakami, Jun-ichiro Inoue, Takeharu Sakamoto
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] Epha2 cleavage by MT1-MMP acts as a switch converting a tumor suppressor into an oncoprotein and could be a possible target for cancer diagnosis2018
- Author(s)
  Koshikawa N & Seiki M
- Organizer
  ISOBM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] 1.Mint3を標的としたがん治療の可能性2018
- Author(s)
  坂本毅治，林哲郎，福井優也，鄭裕花，村上善則，清木元治
- Organizer
  第6回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] がん抑制因子から促進因子に変換するEphA2プロセシングの解明2018
- Author(s)
  1.越川直彦、星野大輔、清木元治
- Organizer
  第77回日本癌学会学術総会（大阪）
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] 浸潤細胞の捕獲を目的としたアッセイ法の開発2018
- Author(s)
  滝野隆久、清木元治
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] 肝がん診断の新規バイオマーカーの開発2017
- Author(s)
  中川将利、吉田栄作、吉村徹、清木元治、越川直彦
- Organizer
  第26回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] Playing with MT1-MMP for 25 years2017
- Author(s)
  Seiki, M.
- Organizer
  International Proteolysis Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] 炎症性モノサイトにおけるAPBA3/Mint3はがん転移性ニッチ形成を制御する2017
- Author(s)
  坂本毅治、原敏朗、中岡寛樹、林哲郎、村上善則、清木元治
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] エクソソームは細胞膜突起構造を増強し、浸潤活性を惹起する2017
- Author(s)
  星野大輔、清木元治、越川直彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] Mint3は線維芽細胞においてL1CAM 発現を誘導することでインテグリンα5β1を介したがん細胞増殖と造腫瘍能を促進する2017
- Author(s)
  坂本毅治、清木元治
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] ERKシグナル標的分子RNF126はミトコンドリアへの代謝フラックスを変えることでアノイキス抵抗性を制御する2016
- Author(s)
  坂本毅治、芳野聖、中岡寛樹、金森茜、清木元治、村上善則
- Organizer
  日本がん学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] 新たな肝細胞がん診断のバイオマーカーの同定2016
- Author(s)
  越川直彦、安田宏、清川寛、伊東文生、中川将利、吉田栄作, 吉村徹, 清木元治
- Organizer
  日本がん学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] 線維芽細胞におけるMint3は腫瘍増殖を促進する2016
- Author(s)
  中岡寛樹、金森茜、清木元治、村上善則、坂本毅治
- Organizer
  日本がん学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16H04695
[Presentation] Membrane type-1 matrix metalloproteinase promotes invasive growth signals of cancer cells by cell surface proteolysis2013
- Author(s)
  Koshikawa, N., Seiki, M.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Membrane type- 1 matrix metalloproteinase promotes invasive growth signals of cancer cells by cell surface proteolysis2013
- Author(s)
  Koshikawa, N., Seiki, M
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] マクロファージにおけるMint3 はがん転移を促進する2013
- Author(s)
  坂本　毅治、原　敏朗、清木　元治
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] 新規HIF 活性化分子Mint3は単球・マクロファージにおいてがん転移を促進する2013
- Author(s)
  坂本　毅治、原　敏朗、清木　元治
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] 新規HIF活性化分子Mint3のマクロファージでのがん悪性化における役割2013
- Author(s)
  坂本　毅治、原　敏朗、清木　元治
- Organizer
  第22回日本がん転移学会学術集会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Mint3 promotes tumor malignancy in cancer and stromal cells2013
- Author(s)
  Sakamoto,T. Hara,T., and Seiki,M
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference
- Place of Presentation
  USA, Maui
- Invited
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] 新規HIF活性化分子Mint3のマクロファージでのがん悪性化における役割2013
- Author(s)
  坂本　毅治、原　敏朗、清木　元治
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] ヒト癌細胞においてインテグリンα2β1と複合体を形成する蛋白質のプロテオミクスによる同定と解析2012
- Author(s)
  小西知江子、星野大輔、越川直彦、清木元治
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Mint3 promotes tumor malignancy in cancer and stromal cells2012
- Author(s)
  Sakamoto,T., Hara,T., and Seiki, M
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] 新規HIF活性化因子・Mint3の生体における機能の解析2012
- Author(s)
  坂本　毅治、原　敏朗、清木　元治
- Organizer
  第85回日本生化学会総会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] 卵巣がんにおけるMT1-MMPによるHB-EGFの活性化についての研究2012
- Author(s)
  越川直彦、清木元治
- Organizer
  第21回　日本がん転移学会学術集会・総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Mint3 is a new molecular target for metastasis suppression2012
- Author(s)
  Sakamoto T, Seiki M.
- Organizer
  The 16th JFCR-ISCC
- Place of Presentation
  東京
- Year and Date
  2012-01-25
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Deletion of the Mint3 gene in mice abrogates macrophage functions and increases resistance to cancer metastasis2011
- Author(s)
  原敏朗、三村耕平、坂本毅治、清木元治
- Organizer
  平成23年度がん若手研究者ワークショップ
- Place of Presentation
  長野
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] MT1-MIMP is a multidimensional regulator of tumor microenvironment2011
- Author(s)
  清木元治
- Organizer
  ゴードン会議
- Place of Presentation
  Rhode Island、米国(招待講演)
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Ubiquitin ligase RNF126 serves as a gate keeper from glycolysis to oxidative phosphorylation and regulates tumor growth2011
- Author(s)
  Yoshino S, Sakamoto T Seiki M.
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] MT1-MMP is a multidimensional regulator of tumor microenvironment2011
- Author(s)
  Seiki, M
- Organizer
  Gordon Research Conference
- Place of Presentation
  Smithfield, U.S.A
- Invited
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Ring finger protein 126, RNF126, is a new E3 ubiquitin ligase that serves as a gate keeper from glycolysis to oxidative phosphorylation and regulates tumor growth2011
- Author(s)
  芳野聖子、坂本毅治、清木元治
- Organizer
  平成23年度がん若手研究者ワークショップ
- Place of Presentation
  長野
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] MT1-MMP: a multidimensional regulator of tumor microenvironment2011
- Author(s)
  清木元治
- Organizer
  第3回CREST-SBM国際会議「がん細胞の数理科学」
- Place of Presentation
  広島大学医学部広仁会館(招待講演)
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloprotease2011
- Author(s)
  Sakamoto T, Seiki M.
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] ROLES OF THE CYTOPLASMIC TAIL OF MT1-MMP; INVADOPODIAFORMATION AND HIF-1 ACTIVATION2011
- Author(s)
  清木元治
- Organizer
  Stony Brook 大学特別セミナー
- Place of Presentation
  New York,米国(招待講演)
- Year and Date
  2011-08-16
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] ROLES OF THE CYTOPLASMIC TAIL OF MT1-MMP; INVADOPODIAFORMATION AND HIF-1 ACTIVATION2011
- Author(s)
  清木元治
- Organizer
  国際プロテオリシス学会
- Place of Presentation
  San Diego、米国(招待講演)
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] 悪性乳がんにおける、造腫瘍機能促進に関与する新規NF-κB標的遺伝子の解析2011
- Author(s)
  呉羽拓、山口憲孝、越川直彦、渡辺慎哉、清木元治、仙波健太郎、井上純一郎
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Deletion of the Mint3/Apba3 Gene in Mice Abrogates Macrophage Functions and Increases Resistance to Lipopolysaccharide-induced Septic Shock.2011
- Author(s)
  Hara T Mimura K, Hara T, Sakamoto T, Seiki M.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] MT1-MMP is a potent regulator of malignant progression in tumor microenvironment.2011
- Author(s)
  Koshikawa, N., Seiki. M.
- Organizer
  Mathematical Methods in Cancer Cell Biology
- Place of Presentation
  Hiroshima
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Mint3 in tumor stromal cells promotes tumor metastasis2011
- Author(s)
  Mimura K, Hara T, Sakamoto T, Seiki M.
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Analysis of the regulatory mechanism of HIF-1 activation by Mint3 during normoxia2011
- Author(s)
  Jane S. Weng, Sakamoto T, Seiki M.
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] ZF21, a novel focal adhesion-related protein, promotes cancer cell invasion2011
- Author(s)
  Nagano M, Hoshino D, Sakamoto T, Okihara R, Konishi M, Ko-shikawa N, Akizawa T, Seiki M
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Systemic survey of substrates and regulators of MT1-MMP2011
- Author(s)
  清木元治
- Organizer
  韓国分子生物学会総会
- Place of Presentation
  ソウル、韓国(招待講演)
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Proteolytic activation of HB-EGF by MT1-MMP in ovarian carcinoma cells2011
- Author(s)
  越川直彦、鍋島一樹、宮本新吾、目加田英輔、清木元治
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] がん細胞膜上の微小環境-悪性化制御因子としてのMT1-MMP-2011
- Author(s)
  越川直彦、清木元治
- Organizer
  第20回日本がん転移学会学術総会
- Place of Presentation
  浜松
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Mint3 in tumor stromal cells promotes tumor metastasis2011
- Author(s)
  Mimura K, Hara T, Sakamoto T, Seiki M.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Ubiquitin ligase RNF126 serves as a gate keeper from glycolysis to oxidative phosphorylation and regulates tumor growth2011
- Author(s)
  Seiko Yoshino, Sakamoto T Seiki M.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] MT1-MMP/Mint3は通常酸素下でHIF-1を活性化しマクロファージおよび癌細胞の解糖系を亢進させる2011
- Author(s)
  Sakamoto T, Seiki M.
- Organizer
  日本がん分子標的治療学会第15回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Analysis of the regulatory mechanism of HIF-1 activation by Mint3 during normoxia2011
- Author(s)
  Jane S. Weng, Sakamoto T, Seiki M.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Mint3/APBA3 regulating HIF-1 activation in macrophages play a critical role in LPS-induced septic shock in a mouse model2011
- Author(s)
  Hara T, Hara T, Sakamoto T, Seiki M.
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloprotease2011
- Author(s)
  Sakamoto T, Seiki M.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Mint3 enhances the activity of HIF-1 in macrophages by suppressing the activity of FIH-12010
- Author(s)
  坂本毅治、清木元治
- Organizer
  第19回日本がん転移学会学術集会・総会
- Place of Presentation
  金沢市文化ホール(金沢市)
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] MT1-MMPはプロテアーゼ活性非依存的にHIF-1を活性化しマクロファージのエネルギー産生を制御する2010
- Author(s)
  坂本毅治、清木元治
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] がん微小環境での悪性化制御因子としてのMT1-MMPの役割2010
- Author(s)
  越川直彦、清木元治
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] ゲノムワイドsiRNAライブラリーを用いた新規低酸素適応因子の同定2010
- Author(s)
  芳野聖子、清木元治
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] MT1-MMPによるLuのプロセシングを介した細胞接着制御についての検討2010
- Author(s)
  越川直彦、清木元治
- Organizer
  第19回日本がん転移学会学術集会・総会
- Place of Presentation
  金沢市文化ホール(金沢市)
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] Mint3 enhances the activity of hypoxia inducible factor-1 in macrophages by suppressing the activity of factor inhibiting HIF-12010
- Author(s)
  Sakamoto, T. and Seiki,M
- Organizer
  8th Joint Conference of the American Association for Cancer Research and Japanese Cancer Association
- Place of Presentation
  Waikoloa, Hawai, U.S.A
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] A Systemic survey of substracts and regulators of MT1-MMP2009
- Author(s)
  清木元治
- Organizer
  Six General Meeting of the International Proteolysis Society
- Place of Presentation
  Australia
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] コラーゲン内三次元環境下でのMT1-MMP依存性増殖を指標にした癌細胞株14種の分類2007
- Author(s)
  生見尚子、清木元治
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、横浜市
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] 14癌細胞株のコラーゲン内三次元増殖におけるMT1-MMPの依存性とMM1270の効果2007
- Author(s)
  生見尚子、清木元治
- Organizer
  第16回日本がん転移学会総会
- Place of Presentation
  富山国際会議場、富山県
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] 招待講演・膜型マトリックスメタロプロテアーゼによる細胞機能制御2007
- Author(s)
  清木元治
- Organizer
  日本ヒトプロテオーム機構第5回大会
- Place of Presentation
  日本科学未来館、東京
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] 膜型MMPによる細胞表層のプロテオリシスと癌細胞の悪性形質の制御2007
- Author(s)
  越川直彦、清木元治
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜、横浜市
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] MT1-MMPはマクロファージの浸潤においてECM分解とケモタキシンスをそれぞれ促進する2007
- Author(s)
  坂本毅治、清木元治
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、横浜市
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] ラミニンγ2単鎖に特異的に反応するモノクリナール抗体の作製2007
- Author(s)
  越川直彦、清木元治
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、横浜市
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] マクロファージにおいてMT1-MMPは細胞外基質の分解とエネルギー産生を促進する2007
- Author(s)
  坂本毅治、清木元治
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜、横浜市
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] がんの生物像を規定する微小環境:膜型MMPによる細胞表層のプロテオリシスと癌細胞の悪性形質の獲得2006
- Author(s)
  越川直彦、清木元治
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17014019
[Presentation] MT1-MMP/Mint3を介した mTORによるHIF-1活性化
- Author(s)
  坂本毅治、清木元治
- Organizer
  第1回がんと代謝研究会
- Place of Presentation
  鶴岡
- Data Source
  KAKENHI-PROJECT-22220014

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Seiki Motoharu 清木 元治

SEIKI Motoharu 清木 元治

清水 元治 セイキ モトハル

清木 元治

Research Projects

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Co-Researchers

Analysis of MT1-MMP-dependent molecular pathways in the diversity and transformation of hepatocellular carcinomaPrincipal Investigator

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Study of MT1-MMP in cancerPrincipal Investigator

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MT1-MMPを介してがん悪性形質を制御するタンパク質の解析Principal Investigator

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がん研究の資材有効保存と利用に関する研究Principal Investigator

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Tumor-stroma interaction mediated by proteasesPrincipal Investigator

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Disorganization of cell and tissue systems in cancer

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Analysis of the proteolytic events on cell surface through proteomic approachPrincipal Investigator

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Research of the physiological functions of membrane-type matrix metalloproteinasesPrincipal Investigator

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細胞外基質分解とがん細胞の浸潤制御機構Principal Investigator

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癌細胞表層における細胞外マトリックス分解制御機構の解析Principal Investigator

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がんの生物学的特性に関する研究の総括

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Activation of matrix metalloproteinases on cell surfacePrincipal Investigator

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Isolation and analysis of new memnrane-type matrix metalloproteinasesPrincipal Investigator

Principal Investigator

Seiki Motoharu 清木元治

SEIKI Motoharu 清木元治

清水元治セイキモトハル

清木元治