Nose Kiyoshi 野瀬清

… Alternative Names

NOSE Iyoshi 野瀬清

NOSE Kiyoshi 能瀬清

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Researcher Number	70012747
Other IDs
Affiliation (Current)	2025: 昭和大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help	2008: 昭和大学, 薬学部, 客員教授 1992 – 2007: 昭和大学, 薬学部, 教授 2000: 昭和大, 薬学部, 教授 1995: 昭和大学, 薬学部・微生物薬品化学, 教授 1993: 昭和大学, 薬学部・微生物薬品化学教室, 教授 … More 1986 – 1992: 東京大学, 医科学研究所, 助教授 1991: 東京大学医科学研究所, 癌細胞, 助教授 1990: The Institute of Medical Science, The University of Tokyo, 癌細胞学研究部, 助教授 1989 – 1990: 東京大学, 医科学研究所・癌細胞, 助教授 1988: 東京大学, 医科学研究学所, 助教授 1988: 東京大学, 医科研, 助教授 1986: 東大, 医科学研究所, 助教授 1986: 東大医科研, 助教授 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Biological pharmacy Except Principal Investigator Biological Sciences / Biological pharmacy / Orthopaedic surgery / Laboratory animal science / Cell biology
Keywords	Principal Investigator c-fos / Hic-5 / 活性酸素 / cDNA / 転写制御 / レドクス / がん遺伝子 / 核移行 / パキシリン / 細胞接着斑 … More / 遺伝子発現 / TGFβ / focal adhesion / nuclear lozalization / paxillin / 酸化ストレス / 接着斑 / 転写 / TGF-beta / 骨芽細胞 / レポーター / p16 / Zn-フィンガー / 過酸化水素 / osteopontin / osteoblastic cells / tumor promoter / 遺伝子クローニング / 発癌プロモーター / 細胞増殖 / Cーキナ-ゼ / オステオポンチン / CDNAクロ-ニング / 発癌プロモ-タ- / C-kinase / TPA / 白血病細胞 / フォルボールエスエル / カルシウム / 発癌促進物質 / 〓〓酵素 / 細胞内pH / C-キナーゼ / mitochondria / NADPH oxidase / reactive oxygen species / TGFb / 間葉系遺伝子 / EMT / プロテオーム / DNAアレイ / Nox4 / TGF-β / ミトコンドリア / NADPHオキシダーゼ / 上皮細胞 / p38 / MMP / 核マトリクス / LIM蛋白質 / Hic-5蛋白質 / PTP-PEST / transcription / NFkappaB / JE gene / active oxygen / NFκB / JE遺伝子 / anti-cancer drugs / Spl transcription factor / luciferase / drug screening systems / p21 / WAFl / WAF-1 / p53蛋白質 / 薬物スクリーニング / WAF1遺伝子 / 薬物探索系 / ルシフェラーゼ / 薬物探索法 / p21遺伝子 / gene expression / Zn-finger / Senescence / フオリスタチン / TGF-β1 / Znフィンガー / 細胞老化 / ras / 発がんプロモーター / 転写誘導 / トポイソメラーゼ / クロマチン / C-yos / 上皮細胞増殖因子 / myc / 形質転換 / 低酸素 / 血管新生 / 抗がん剤 / VEGF / 抗癌剤 / 炎症性サイトカイン / FE遺伝子 / レドックス制御 / 温熱療法 / シャペロン / 熱ショック蛋白 / 癌抑制遺伝子 / cDNAクローニング / ロイシンジッパ- / 遺伝子誘導 / TGFーβ_1 … More Except Principal Investigator 細胞周期 / Hic-5 / RB蛋白質 / がん抑制遺伝子 / がん遺伝子 / サイクリン / TGFβ / 癌遺伝子 / 遺伝子発現 / ミクロチスチン / 温度感受性変異株 / HIC-5 / 免疫応答 / ras遺伝子 / オートクリン因子 / pepsinogen isozymel / 前癌変化 / パキシリン / cyclin D1 / 細胞接着 / ユビキチン / 癌抑制遺伝子 / 発がんプロモ-タ- / オカダ酸クラス発がんプロモ-タ- / オカダ酸 / cdc2キナ-ゼ / Cキナ-ゼ / CNーTPBP / cdc2キナーゼ / Lymphokine / Immune Desponse / T Cell Growth / Tumor Antigen / Tumor Supressor Gene / Tumor Promoter / Viral Oncogene / Oncogene / リンフォカイン / T細胞の増殖 / 腫瘍抗原 / ウイルス発がん / focal adhesion / expression vectors / Zn finger protein / differentiation / Alu配列 / Znフィンガー / 細胞接着斑 / Zn-フィンガー / 細胞分化 / Mechanical Stress / Chondrocyte / Osteoblast / Bone Resorption / Bone Formation / 力学的刺激 / 軟骨細胞 / 骨芽細胞 / 骨吸収 / 骨形成 / Signal transduction in fertilization / DNA binding molecule of sperm / MHC class II molecule of sperm / P56^<lck> of vitelline membrane / CD4 of vitelline membrane / vitelline membrane / Sugar chain of Zona pellucida / Zona pellucida / L_3T_4原分子 / 卵黄膜 / 外来遺伝子結合性 / クラスIIMHC抗原 / 中性糖 / 哺乳類 / P56lck / CD_4〓分子 / 卵子 / 精子 / 糖鎖 / 卵透明帯 / 受精の情報伝達 / P56^<lck> キナーゼ / CD_4分子 / MHCクラスII分子 / 透明帯結合蛋白 / 透明帯酸性糖鎖 / 透明帯中性糖鎖 / 変精の情報伝達 / 外来性DNA結合分子 / 精子MHCクラスII分子 / 卵黄膜P56^<lcr> / 卵黄膜CD_4 / 卵子卵黄膜 / 卵子戸明帯糖鎖 / 卵子透明帯 / O^6-アルキルグアニン / アルキル化 / DNA附加体 / 発がん / DNA修復 / DNA複製起点 / DnaA蛋白質 / N-myc蛋白質 / ホルボールエステル / コフィリン / イノシトール輸送 / チトクロームPー448 / 1ーメチルアデノシン / cーfos遺伝子 / cーキナーゼ / GSTーp / マーカ / トランスジェニック動物 / 発癌遺伝子 / c-キナーゼ / GST-p / マーカー / matrix metalloproteinase / MMP9 / ミトコンドリア / マトリックスメタロプロテアーゼ / サイクリンD1 / 足場依存性増殖 / p21 / RhoA / 転写 / c-fos / 接着斑 / 核移行 / G-蛋白質 / 接着 / 転写因子 / がん転移 / マクロライド / チロシンキナーゼ阻害剤 / がん化シグナル / Ets-1 / CDKインヒビター / 転移 / p21^<waf1> / RB / 血管新生 / アポトーシス / Ablチロシンキナーゼ / Srcチロシンキナーゼ / p7056キナーゼ / MAPキナーゼ / Srcがん遺伝子 / Rasがん遺伝子 / U0126 / スクリーニング / シグナル伝達 / 足場非依存性増殖 / 増殖制御 / cDNA / TGF-beta / TGFbeta / DNAポリメラーゼalpha / HSP65 / HSP40 / HSP47 / 分子シャペロン / ストレス蛋白質 / 熱ショック蛋白質 / ^<cdc2>キナーゼ / RV蛋白質 / プロテインキナ-ゼC / TRE / JE遺伝子 / アラキドン酸 / プロティンフォスファタ-ゼ / リン酸化標的タンパク / ケラチノサイト / 皮膚 / 発がんプロモ-ション / カルシウム非依存性Cキナ-ゼ / protein kinase C / プロスタグランジンE_2 / 蛋白質脱リン酸化酵素2A / ヒストンデアセチラ-ゼ / cーmosキナ-ゼ / TGFーβ / ホスファチジルセリン / パピロ-マ / クレアチンキナ-ゼ / 蛋白リン酸化 / 発癌プロモ-タ- / 発癌プロモ-ション / メタロチオネイン / アラキドン酸代謝 / プロテインフォスファターゼ / カリキュリンA / 発がんプロモーター / オカダ酸クラスプロモーター / トリコスタチン / DNA複製開始点 / cーmos蛋白質 / デストリン Less

A novel cascade of TGF-β signaling dependent on mitochondrial reactive oxygen species and its biological significance
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Showa University
細胞接着斑-核シャトル複合体による足場依存性増殖のための安全装置の破綻と癌化
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
Regulation of epithelial-mesenchymal transition (EMT) by redox-based mechanismsPrincipal Investigator
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5による細胞膜-核シグナル伝達の制御機構
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
細胞老化関連遺伝子を標的とした新規抗がん剤の探索Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
Redox regulation of cell adhesion signalsPrincipal Investigator
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
増殖制御遺伝子エンハンサーを用いた抗がん剤の探索Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
細胞がん化のシグナル伝達の解析と特異的阻害剤の探索
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Institute of Infectious Diseases
細胞接着斑蛋白質Hic-5の細胞老化、がん化における役割Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Showa University
ANALYSIS OF CYTOPLASMIC FACTORS THAT PARTICIPATE IN GROWTH ARREST INDUCED BY OXIDATIVE STRESSPrincipal Investigator
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
Molecular mechanism of the interaction between signals generated by BMP and mechanical stress in osteoblasts
- Principal Investigator
  
  NODA Masaki
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Role of the Novel Gene, HIC-5, that encodes a Zn-finger Protein in Cellular Differentiation.
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
活性酸素による増殖関連遺伝子誘導の分子機構Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Showa University
Establishment of screening systems that detect chemicals against circulatory diseases using redox changes as an indicator.Principal Investigator
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
Molecular Mechanism for Redox-Regulation of the JE genePrincipal Investigator
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
熱ショック・ストレス蛋白質の機能・発現機構とその制御Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Showa University
熱ショック・ストレス蛋白質の機能、発現機構とその制御
- Principal Investigator
  
  永田和宏
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
細胞周期の制御機構における癌遺伝子、癌抑制遺伝子および関連遺伝子の研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
TGFbetaで誘導されrasで発現の消失する遺伝子(HIC-5)の増殖における機能の解析
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Showa University
酸化ストレスによる細胞増殖抑制の分子機構Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Showa University
Reles of TGF beta-1 induckble novel gence in giowth regulationPrincipal Investigator
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
細胞周期の制御機構における癌遺伝子・癌抑制遺伝子および関連遺伝子の研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
TGFβにより誘導される遺伝子の細胞増殖における機能の解析Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Showa University
細胞周期の制御機構における癌遺伝子、癌抑制遺伝子および関連遺伝子の研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
TGFーβにより誘導される遺伝子の分離とその細胞増殖における機能の解析Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
発がんプロモ-ションにおけるシグナル伝達と遺伝子発現の解析
- Principal Investigator
  
  黒木登志夫
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Molecular approach to mammalian fertilization and its application to gene transfer into fertilized egg
- Principal Investigator
  
  MORI Tsuneatsu
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tokyo
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
発がんプロモーションの機構とその阻害
- Principal Investigator
  
  FUJIKI Hirota
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
増殖因子、分化因子による発癌の促進と抑制のメカニズム解析
- Principal Investigator
  
  KUROKI Toshio
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
発がんプロモ-ションの機構とその阻害
- Principal Investigator
  
  藤木博太
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
発がんプロモ-ションの機構とその阻害
- Principal Investigator
  
  藤木博太
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
哺乳類O^6-アルキルグアニン修復酵素遺伝子のクローニング
- Principal Investigator
  
  許南浩
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
c-fos遺伝子転写制御のシグナルPrincipal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Information Exchange on Cancer Research with North American Countries
- Principal Investigator
  
  YAMAGUCHI Nobuo, 河井貞明
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  The Institute of Medical Science, The University of Tokyo
Study on the cascade of gene expression induced by tumor promoters.Principal Investigator
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Institute of Medical Science, University of Tokyo
ヒトC-fos遺伝子転写におけるトポイソメラーゼ, I, IIの機能の解析Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
アメリカ大陸を中心としてがん研究先進グループとの研究交流
- Principal Investigator
  
  KAWAI Sadaaki
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Overseas Scientific Research
- Research Institution
  The University of Tokyo
化学発癌過程における細胞形質発現の推移とその安定化
- Principal Investigator
  
  伊東信行
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University
発癌遺伝子を導入されたトランスジエニック動物での遺伝子産物の発現とその免疫応答
- Principal Investigator
  
  MORI Tsuneatsu
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
myc遺伝子産物による上皮細胞の形質転換とそれに伴う核骨格、細胞骨格の変化の解析Principal Investigator
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
化学発癌過程における細胞形質発現の推移とその安定化
- Principal Investigator
  
  伊東信行
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University
Role of Ca^<2+> on c-fos expression during differentiation of leukemia cells.Principal Investigator
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Institute of Medical Science, University of Tokyo

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Competitive nuclear export of cyclin D1 and Hic-5 regulates anchorage-dependence of cell growth and survival2009
- Author(s)
  Kazunori Mori, Etsuko Hirao, Yosuke Toya, Yukiko Oshima, Fumihiro Ishikawa, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  Mol. Biol Cell. 20
  
  Pages: 218-232
- Data Source
  KAKENHI-PROJECT-19570185
[Journal Article] Downregulation of hepatocyte nuclear factor-4α and its role in regulation of gene expression by TGF-β in mammary epithelial cells2008
- Author(s)
  Fumihiro, Ishikawa, Takashi Akimoto, Haruka Yamamoto, Yuri Araki, Toshihiko Yoshie, Kazunori Mori, Hidetoshi Hayashi, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  Exp. Cell Res. 314
  
  Pages: 2131-2141
- Data Source
  KAKENHI-PROJECT-19570185
[Journal Article] Induction of Matrix Metalloprotease Gene Expression on an Endothelial Cell Line by Direct Interaction with Malignant Cells.2007
- Author(s)
  Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K
- Journal Title
  
  Cancer Sci. 98巻・1号
  
  Pages: 58-67
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-β1-inducible clone involved in regulation of mitochondrial function, cell growth and death.2007
- Author(s)
  Kanome, T., Itoh, N., Mori, K., Kim-Kaneyama, J., Shibanuma, M., Nose, K.
- Journal Title
  
  Oncogene. (in press)
- Data Source
  KAKENHI-PROJECT-18013047
[Journal Article] Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-β1-inducible clone involved in regulation of mitochondrial function, cell growth and death.2007
- Author(s)
  Kanome, T., Itoh, N., Mori, K., Kim-Kaneyama, J., Shibanuma, M., Nose, K.
- Journal Title
  
  Oncogene (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells2007
- Author(s)
  Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K.
- Journal Title
  
  Cancer Sc. 98
  
  Pages: 58-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells.2007
- Author(s)
  Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K
- Journal Title
  
  Cancer Sc. 98巻・1号
  
  Pages: 58-67
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells.2007
- Author(s)
  Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K
- Journal Title
  
  Cancer Sci. 98巻・1号
  
  Pages: 58-67
- Data Source
  KAKENHI-PROJECT-18013047
[Journal Article] Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-β1-inducible clone involved in regulation of mitochondrial function, cell growth and death.2007
- Author(s)
  Kanome, T., Itho, N., Mori, K., Kim-Kaneyama, J., Shibanuma, M., Nose, K.
- Journal Title
  
  Oncogene. in press
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex.2006
- Author(s)
  Mori, K., Asakawa, M., Hayashi, M., Imura, M., Ohki, T., Hirao, E., Nose, K., Shibanuma, M.
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 22048-22061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Inhibition of angiogenesis and HIF-la activation by antimycin A1.2006
- Author(s)
  Maeda, M., Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K.`
- Journal Title
  
  Biol. Pharm. Bullet. 29巻・7号
  
  Pages: 1344-1348
- Data Source
  KAKENHI-PROJECT-18013047
[Journal Article] Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex.2006
- Author(s)
  Mori, K., Asakawa, M., Hayashi, M., Imura, M., Ohki, T., Hirao, E., Nose, K., Shibanuma, M.
- Journal Title
  
  J. Biol. Chem. 281巻・31号
  
  Pages: 22048-22061
- Data Source
  KAKENHI-PROJECT-18013047
[Journal Article] Inhibition of angiogenesis and HIF-1a activation by antimycin A1.2006
- Author(s)
  Maeda, M., Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K.
- Journal Title
  
  Biol. Pharm. Bullet :. 29巻・7号
  
  Pages: 1344-1348
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex.2006
- Author(s)
  Mori, K., Asakawa, M., Hayashi, M., Imura, M., Ohki, T., Hirao, E., Nose, K., Shibanuma, M.
- Journal Title
  
  J. Biol. Chem. 281巻・31号
  
  Pages: 22048-22061
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Inhibition of angiogenesis and HIF-1a activation by antimycin A1.2006
- Author(s)
  Maeda, M., Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K.
- Journal Title
  
  Biol. Pharm. Bullet. 29巻・7号
  
  Pages: 1344-1348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Inhibition of angiogenesis and HIF-la activation by antimycin A1.2006
- Author(s)
  Maeda, M., Hasebe, Y, Egawa, K., Shibanuma, M., Nose, K.
- Journal Title
  
  Biol.Pharm.Bullet. 29
  
  Pages: 1344-1348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Anthracyclines, Small-Molecule Inhibitors of Hypoxia-Inducible Factir-1 Alpha Activation.2006
- Author(s)
  Y.Yamazaki, Y.Hasebe, K.Egawa, K.Nose, S.Kunimoto, D.Ikeda.
- Journal Title
  
  Biol. Pharm. Bullet :. 29巻・10号
  
  Pages: 1999-2003
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Uni-axial stretch regulates intracellular localization of Hic-5, which is expressed in smooth muscle cells in vivo.2005
- Author(s)
  Shuri Kaneyama, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  J.Cell Sci. (In press)
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Uni-axial stretching regulates intracellular localization of Hic-5, which is expressed in smooth muscle cells in vivo.2005
- Author(s)
  Shuri Kaneyama, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  J.Cell Sci. 118(5)
  
  Pages: 937-949
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Uni-axial stretch regulates intracellular localization of Hic-5, which is expressed in smooth muscle cells in vivo.2005
- Author(s)
  Kaneyama, A., Nose, K., Shibanuma, M.
- Journal Title
  
  J.Cell Sci. 118
  
  Pages: 937-949
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Redox control of protein trafficking.2005
- Author(s)
  Nose, K.
- Journal Title
  
  Antioxidants & Redox Signaling 7(3&4)
  
  Pages: 303-307
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-52005
- Author(s)
  M.Shibanuma, K.Mori, J.Kim-Kaneyama, K.Nose.
- Journal Title
  
  Antioxidants ＆ Redox Signaling 7巻・2号
  
  Pages: 335-347
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Involvement of FAX and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-52005
- Author(s)
  M.Shibanuma, K.Mori, Joo-ri Kim-Kaneyama, K.Nose
- Journal Title
  
  Antioxidants & Redox Signaling (In press)
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-5.2005
- Author(s)
  M.Shibanuma, K.Mori, J.Kim-Kaneyama, K.Nose.
- Journal Title
  
  Antioxidants ＆ Redox Signaling 7
  
  Pages: 335-347
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Uni-axial stretch regulates intracellular localization of Hic-5, which is expressed in smooth muscle cells in vivo.2005
- Author(s)
  Kaneyama, A., Nose, K., Shibanuma, M.
- Journal Title
  
  J. Cell Sci. 118巻・2号
  
  Pages: 937-949
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-52005
- Author(s)
  M.Shibanuma, K.Mori, Joo-riKim-Kaneyama, K.Nose
- Journal Title
  
  Antioxidants & Redox Signaling 7(3&4)
  
  Pages: 335-347
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] A LIM protein, Hic-5, functions as a potential coactivator for Sp1.2004
- Author(s)
  Shibanuma, M., Kim-Kaneyama, J., Sato, S., Nose.K.
- Journal Title
  
  J.Cell. Biochern. 91
  
  Pages: 633-645
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Invasive potential induced under long-term oxidative stress in mammary epithelial cells.2004
- Author(s)
  Kazunori Mori, Motoko Shibanuma. Kivoshi Nose
- Journal Title
  
  Cancer Res. 64
  
  Pages: 7464-7472
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Gene expression profiling identifies a role for CHOP during inhibition of the mitochondrial respiratory chain
- Author(s)
  Fumihiro Ishikawa, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  J. Biochem. (Epub ahead of print)
- NAID
  10025187713
- Data Source
  KAKENHI-PROJECT-19570185
[Journal Article] Characterization of Jumping translocation breakpoint (JTB) gene produc1 isolated as a TGF-pl-inducible clone involved in regulation of mitochondrial function, cell growth and death.
- Author(s)
  Kanome, T., Itoh, N., Mori, K., Kim-Kaneyama, J., Shibanuma, M., Nose, K.
- Journal Title
  
  Uncogene (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Presentation] Transcriptional induction of MMP10 by TGFβ mediated by MEF2 and class IIa HDACs2009
- Author(s)
  Fumihiro Ishikawa, Emi Kaneko, Toshihiko Yoshie, Kiyoshi Nose, and Motoko Shibanuma
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver, British Columbia, Canada.
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-19570185
[Presentation] TGFβによるMEF2とClassIIaHDACを介したMMP10転写制御機構2008
- Author(s)
  石川文博、野瀬清、柴沼質子
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19570185
[Presentation] MMP9の発現制御に特異的に関わる新規TGFβ転写制御機構の解析2008
- Author(s)
  三瓶瑠利子、石川文博、野瀬清、柴沼質子
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19570185

1. SHIBANUMA Motoko (60245876)

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Nose Kiyoshi 野瀬 清

NOSE Iyoshi 野瀬 清

NOSE Kiyoshi 能瀬 清

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Regulation of epithelial-mesenchymal transition (EMT) by redox-based mechanismsPrincipal Investigator

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細胞老化関連遺伝子を標的とした新規抗がん剤の探索Principal Investigator

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Redox regulation of cell adhesion signalsPrincipal Investigator

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増殖制御遺伝子エンハンサーを用いた抗がん剤の探索Principal Investigator

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細胞接着斑蛋白質Hic-5の細胞老化、がん化における役割Principal Investigator

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Nose Kiyoshi 野瀬清

NOSE Iyoshi 野瀬清

NOSE Kiyoshi 能瀬清