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KIKUCHI Kunimi  菊地 九二三

ORCIDConnect your ORCID iD *help
… Alternative Names

菊地 九二三  キクチ クニミ

菊池 九二三

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Researcher Number 20006117
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2000 – 2006: 北海道大学, 遺伝子病制御研究所, 教授
1998 – 1999: Hokaido University, Reseach Section of Biochemistry Institute of Immunological S, 免疫科学研究所, 教授
1996 – 1997: 北海道大学, 免疫学研究所, 教授
1996: 北海道大学, 免疫科学研究所, 教授
1995: 北海道大学, 免疫科学研究所・生化学部門, 教授 … More
1990 – 1994: Institute of Immunological Science, Hokkaido University, 免疫科学研究所, 教授
1988: 東北大学, 抗酸菌病研究所, 助教授
1986: 東北大, 抗酸菌病研究所, 助教授
1986: Research Institute for Tuberculosis and Cancer Tohoku University - Associate Pro, 抗酸菌病研究所, 助教授 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Functional biochemistry / 病態医化学 / Pathological medical chemistry / 医学一般
Except Principal Investigator
Functional biochemistry / Functional biochemistry / Pathological medical chemistry / Biological Sciences
Keywords
Principal Investigator
プロテインホスファターゼ / チロシンホスファターゼ / PP1 / PTPεC / セリン / PP2C / PP2A / MRL / PTPε / IL-6 … More / 癌形質 / 発癌 / スレオニンホスファターゼ / プロテインホスファタ-ゼ / JNK / siRNA / Raf-1 / LDP-3 / MKP-7 / NIPP-1 / トウトマイセチン / IL-2 / CTLL-2 / 転移抑制 / トランスジェニックマウス / アポトーシス / 癌化 / 細胞分化 / 蛋白脱リン酸 / 遺伝子発現 / 細胞増殖 / ノザンブロット / LDP / ストレス応答 / M1細胞 / ERK / トートマイセチン / JNKホスファターゼ / Raf / インヒビター2 / B-Raf / DSP / apoptosis / cell differentiation / tautomycetin / dual specificity phosphatase / phosphotyrosine phosphatase / protein phosphatase / 2重特異性ホスファターゼ / トウトマイシン / インヒビター4 / 2重基質特異性ホスファタ-ゼ / セリンホスファタ-ゼ / チロシンホスファタ-ゼ / 二重基質特異性ホスファターゼ / Signal transduction / Protein dephosphorylation / Immune respose / Autoimmune disease / Protein phosphatase / PP2B / 1prマウス / チロシンホスフアターゼ / スレオニン ホスフアターゼ / プロテインホスフアターゼ / 免疫応答 / 自己免疫疾患 / 免疫病態 / Signal Transduction / Thymus / Spleen / lpr Mice / Protein Phosphatase / 分別定量 / B細胞 / T細胞 / 情報伝達 / 胸腺 / 脾臓 / lprマウス / ホスホリラーゼホスファターゼ / グリコゲン合成酵素ホスファターゼ / ラット肝 / 腫瘍原性 / 腫瘍現性 / IL-10 / 蛋白脱リン後 / 細胞周期 / イソホーム / 再生肝 / 肝癌 / 前癌状態 / SoltーFarber発癌系 / 腹水肝細胞 / 肝化学発癌 / cDNA / ラットPP1α … More
Except Principal Investigator
PP1 / PP2A / ホスファターゼ / S6キナーゼ / プロテインホスファターゼ / pp32 / MAPK / 翻訳 / 細胞増殖 / キナーゼ / 癌遺伝子 / 転写調節因子 / 肝発癌 / SET / I-2^<PP2A> / I-1^<PP2A> / LDP4 / MKP7 / TCPTP / Aurora kinase / GSK3β / tautomycetin / phosphatase / kinase / phosphorylation / リン酸化 / S6 / Protein phosphatase / SHP-2 / SHPS-1 / トウトマイシン / がん遺伝子 / がん化 / 細胞周期 / 欠損マウス / カルシニューリン / MAPKホスファターゼ / プロテアソ-ム / プロティンホスファタ-ゼ / Gタンパク質 / グルタチオンSートランスフェラ-ゼ / マ-カ-酵素 / Lymphokine / Immune Desponse / T Cell Growth / Tumor Antigen / Tumor Supressor Gene / Tumor Promoter / Viral Oncogene / Oncogene / リンフォカイン / 免疫応答 / T細胞の増殖 / 腫瘍抗原 / がん抑制遺伝子 / 発がんプロモ-タ- / ウイルス発がん / Glycogen synthase / Skeletal muscle / Liver / Diabetes / ホスホリラーゼ / グリコゲン / グリコゲン合成酵素 / 骨格筋 / 肝 / 糖尿病 / siRNA / 浸透圧刺激 / LDP / ユビキチン / 中心体 / ビメンチン / 阻害剤 / manzamenone / PTP1B / T-cell PTP / オーロラキナーゼ / MARK / dephosphorylation / gsk3b / raf / トウトマイセチン / 脱リン酸化 / calcineurin / 免疫抑制 / 癌化 / トートマイセチン / B cell antigen receptor / Tautomycin / Tyrosine protein phosphatase / threonine protein phosphatase / Serine / Signal transduction / オカダ酸 / アルツハイマー病 / 長期増強 / CD45 / ノジュラリン / B細胞抗原受容体 / チロシンホスファターゼ / トレオニンホスファターゼ / セリン / 細胞内情報伝達 / ノザンブロット分析 / cDNAのクローニング / タンパクチロシン残基ホスファターゼ / タンパクホスファターゼ / ラット肝 / 遺伝子発現制御機構 / 遺伝子クローニング / S-トランスフェラーゼ / グルタチオン / 酵素変異 / 前がん病変 / 肝発がん / mRNA / クロマチンリモデリング活性 / 結合蛋白 / クロマチン免疫沈降法 / FHAドメイン / スプライシング / 転写 / NIPP1 / 二重基質特異性ホスファターゼ / NIPP-1 / アポトーシス / 活性測定法 / 免疫抑制薬 / ノックアウトマウス / Bリンパ腫 / 腹水肝癌細胞 / がん細胞 / 増殖抑制 / インヒビター2 / 阻害蛋白 / 細胞増殖抑制 / 細胞骨格 / リン脂質 / フォスファターゼ / シグナル伝達機構 / リン酸化ペプチド抗体 / アダプター蛋白質 / 細胞内シグナル伝達 / 細胞ガン化 / small GTP結合蛋白質Rho / 細胞骨格リン酸化 / ストレス依存性シグナル伝達 / 膜リン脂質 / Crk / シアリダーゼ / プロティンホスファターゼ / Gタンパク / グルタチオンS-トランスフェラーゼ / マーカー酵素 Less
  • Research Projects

    (29 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (69 People)
  •  mRNA翻訳効率に対する転写過程での刷り込み現象

    • Principal Investigator
      島 礼
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      Miyagi Cancer Center Research Institute
  •  Regulation of cell function by protein dephosphorylation

    • Principal Investigator
      SHIMA Hiroshi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Miyagi Cancer Center Research Institute
      Hokkaido University
  •  チロシンホスファターゼPTPεCのがん抑制機構Principal Investigator

    • Principal Investigator
      菊池 九二三
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  チロシンホスファターゼPTPεCのがん関連分子としての意義の解明Principal Investigator

    • Principal Investigator
      菊池 九二三
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Molecular mechanisms and their significance of protein phosphatase families which control the network-system of signal transductionPrincipal Investigator

    • Principal Investigator
      KIKUCHI Kunimi
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Regulation of translation by protein phosphorylation.

    • Principal Investigator
      SHIMA Hiroshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  発生やがん化に及ぼす内因性Jak-STAT阻害性ホスファターゼPTPεCの役割Principal Investigator

    • Principal Investigator
      菊池 九二三
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  S6キナーゼを中心とする翻訳制御の細胞増殖,発がんにおける関与

    • Principal Investigator
      島 礼
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Regulatgion of translation by protein phosphorylation.

    • Principal Investigator
      SHIMA Hiroshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Tリンパ球におけるS6キナーゼの機能とその制御機構の研究

    • Principal Investigator
      島 礼
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hokkaido University
  •  Studies on control mechanism of protein phosphatases ds a network system of informationPrincipal Investigator

    • Principal Investigator
      KIKUCHI Kunimi
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  プロテインホスファターゼの特異的阻害蛋白遺伝子によるがんの細胞工学的制御

    • Principal Investigator
      水野 佑亮
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Physiological significance of protein phosphatases on cellular signal transduction

    • Principal Investigator
      TAKEDA Masao
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  シグナル伝達機構による細胞増殖制御

    • Principal Investigator
      稲垣 昌樹
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Aichi Cancer Center Research Institute
      Tokyo Metropolitan Institute of Gerontology
  •  発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義Principal Investigator

    • Principal Investigator
      菊地 九二三
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義Principal Investigator

    • Principal Investigator
      菊池 九二三
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義Principal Investigator

    • Principal Investigator
      菊池 九二三
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  肝発癌過程のマーカー酵素の特異的発現機構と機能の解明

    • Principal Investigator
      遠藤 英也
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tottori University
  •  Studies of protein phophatases on immune response in normal and autoimmune disease mice.Principal Investigator

    • Principal Investigator
      KIKUCHI Kunimi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      病態医化学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  肝発癌過程のマ-カ-酵素の特異的発現機構と機能の解明

    • Principal Investigator
      佐藤 清美
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hirosaki University
  •  発癌過程におけるタイプ1型プロテインホスファタ-ゼの異常発現の意義の解析Principal Investigator

    • Principal Investigator
      菊池 九二三
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  肝発癌過程のマ-カ-酵素の特異的発現機構と機能の解明

    • Principal Investigator
      佐藤 清美
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hirosaki University
  •  プロテインホスファタ-ゼによる発癌プロモ-ション過程の解析Principal Investigator

    • Principal Investigator
      菊池 九二三
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  Analysis of Signal Transduction in Immunocompetent Cells by Protein Phosphatase and its Application for Autoimmune DiseasePrincipal Investigator

    • Principal Investigator
      KIKUCHI Kunimi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hokkaido University
  •  肝化学発癌過程の前癌細胞における遺伝子および遺伝子発現の異常の解析

    • Principal Investigator
      佐藤 清美
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hirosaki University
  •  タンパク質リン酸化チロシン脱リン酸化酵素の同定と当該遺伝子のクローニング

    • Principal Investigator
      立木 蔚
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tohoku University
  •  Information Exchange on Cancer Research with North American Countries

    • Principal Investigator
      YAMAGUCHI Nobuo, 河井 貞明
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      The Institute of Medical Science, The University of Tokyo
  •  肝におけるプロティンホスファターゼの本態と意義の研究Principal Investigator

    • Principal Investigator
      菊池 九二三
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医学一般
    • Research Institution
      Tohoku University
  •  Alterations and significance of protein phosphatases, in particular of phosphatase IV, under diabetic conditions

    • Principal Investigator
      TSUIKI Shigeru
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      TOHOKU UNIVERSITY

All 2006 2005 2004

All Journal Article

  • [Journal Article] Vimentin-Ser82 as a memory phosphorylation site in astrocytes.2006

    • Author(s)
      Oguri T, Inoko A, Shima H, Izawa I, Arimura N, Yamaguchi T, Inagaki N, Kaibuchi K, Kikuchi K, Inagaki M.
    • Journal Title

      Genes Cells 11

      Pages: 531-540

    • NAID

      120000961744

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] Characterization of a novel low-molecular- mass dual specificity phosphatase-4(LDP-4) expressed in brain2006

    • Author(s)
      Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K.
    • Journal Title

      Mol Cell Biochem 296

      Pages: 177-184

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] Manzamenones inhibit T-Cell Protein Tyrosine Phosphatase2006

    • Author(s)
      Wakuda Y, Kubota T, Shima H, Okada T, Mitsuhashi S, Aoki N, Kikuchi K, Kobayashi J.
    • Journal Title

      Mar.Drugs 4

      Pages: 9-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] pp32/I-1^<PP2A> negatively regulates the Raf/MEK/ERK pathway.2005

    • Author(s)
      Fukukawa C, Tanuma N, Okada T, Kikuchi K, Shima H.
    • Journal Title

      Cancer Lett 226

      Pages: 155-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] Phosphorylation of Ser-446 determines stability of MKP-7.2005

    • Author(s)
      Katagiri C, Masuda K, Urano T, Yamashita K, Kikuchi K, Shima H.
    • Journal Title

      J Biol Chem 280

      Pages: 14716-14722

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] Characterization of a novel low-molecular-mass dual-specificity phosphaase 3(LDP-3) that enhances activation of JNK and p38.2004

    • Author(s)
      Takagaki K, Satoh T, Tanuma N, Masuda K, Takekawa M, Shima H, Kikuchi K.
    • Journal Title

      Biochem J 383

      Pages: 447-455

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] The oncoprotein I-2^<PP2A>/SET negatively regulates the MEK/ERK pathway and cell proliferation.2004

    • Author(s)
      Fukukawa C, Shima H, Tanuma N, Okada T, Kato N, Adachi Y, Kikuchi K.
    • Journal Title

      Int J Oncol 26

      Pages: 751-756

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge agelas species.2004

    • Author(s)
      Endo T, Tsuda M, Okada T, Mitsuhashi S, Shima H, Kikuchi K, Mikami Y, Fromont J, Kobayashi J.
    • Journal Title

      J Nat Prod 68

      Pages: 1262-1267

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] Protein phosphatase type 2A, PP2A, is involved in degradation of gp130.2004

    • Author(s)
      Mitsuhashi S, Shima H, Tanuma N, Sasa S, Onoe K, Ubukata M, Kikuchi K.
    • Journal Title

      Mol Cell Biochem 269

      Pages: 183-187

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • [Journal Article] Analysis of isoform specific function of PP1 catalytic subunits in mammalian cells using siRNA.2004

    • Author(s)
      Okada T, Fujii T, Tanuma N, Mitsuhashi S, Urano T, Araki Y, Shima H, Kikuchi K.
    • Journal Title

      Int J Oncol 25

      Pages: 1383-1388

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370055
  • 1.  SHIMA Hiroshi (10196462)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 10 results
  • 2.  TANUMA Nobuhiro (40333645)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 6 results
  • 3.  TAMURA Shinri (20124604)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 4.  MIZUNO Yusuke (00002121)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  村松 正実 (10035454)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  TAKEDA Masao (40030853)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  日野田 裕治 (10165128)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  TSUIKI Shigeru (90006065)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  佐藤 清美 (50006079)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  宮城 妙子 (50006110)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  NAKAMURA Kouji (70281839)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  NOMURA Miyuki (40390893)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 13.  KAWAI Sadaaki (70107423)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  野口 民夫 (70135721)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  谷口 直之 (90002188)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  遠藤 英也 (40037320)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  菅沼 雅美 (20196695)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  MATSUZAWA Syu-ichi (80239003)
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  • 58.  貝淵 弘三 (00169377)
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  • 59.  佐藤 公彦 (70003655)
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  • 62.  中島 茂 (60188935)
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  • 66.  渡部 烈 (00057316)
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  • 69.  渡邊 利雄 (60201208)
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