HINO OKIO 樋野興夫

… Alternative Names

Researcher Number	90127910
Other IDs
External Links
Affiliation (Current)	2020: 順天堂大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2003 – 2019: 順天堂大学, 医学部, 教授 2007: 順天堂大学, 医学部・, 教授 2004 – 2005: 順天堂大学, 病理学部, 教授 2001 – 2002: 財団法人癌研究会, 癌研究所・実験病理部, 部長 2000: Cancer Institute, Dept.of Experimental Pathology, Chief, 癌研究所・実験病理部, 部長 … More
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology / Biological Sciences / Cancer epidemiology and prevention / Laboratory animal science / Developmental mechanisms and the body works Except Principal Investigator Laboratory animal science / Hygiene / Experimental pathology / 小児外科 … More
Keywords	Principal Investigator 疾患モデル / 癌抑制遺伝子 / TSC2遺伝子 / 遺伝性癌 / 遺伝性がん / 多段階発がん / Animal model / ヒト結節性硬化症 / Tumor suppressor gene / Eker rat … More Except Principal Investigator トランスジェニックマウス / 肝発癌 / 発がん / がん遺伝子 / がん抑制遺伝子 / B型肝炎ウイルス / 前がん病変 / 潜在がん / 顕在がん / 分子病理 / 実験動物 / シグナル伝達 / 中皮腫 / Erc / 癌遺伝子 / 相同遺伝子組換え / ラット / 発癌 / 腎癌 / 結節性硬化症 / Tsc2遺伝子 / GPIアンカー蛋白 / ノックアウトマウス / バイオマーカー / 画像診断 / アスベスト / DNA再編成 / エンハンサー / X遺伝子 / dbpA / Y box binding protein / 癌抑制院伝子 / ES細胞 / 遺伝子変異 / Nras / mRNA / 白血病 / LEC / 標的遺伝子組換え / 遺伝子トラップ / N-ras / 癌抑制遺伝子 / Eker / Ekerラット / 腎臓 / LECラット / 肝炎肝癌 / ウイルソン病 / DMBA白血病 / PNUリンパ腫 / がん細胞 / DNA修復 / がん転移 / ヒトゲノム / 2国間協同研究 / 2国間共同研究 / 若手支援 / 国際研究者交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 次世代分子解析技術 / アカデミア創薬 / ゲノム・エピゲノム解析支援 / 個別化がん予防 / 国際交流 / ATL発症予防 / 分子疫学コーホート研究 / がん化学予防 / ATL発がん機序 / ATL発症リスク / がん分子標的薬剤 / Erc/mesothelin / 産業衛生 / プロテオミクス / プロテオーム / マイクロアレイ / 職業性呼吸器病 / 胸部エックス線 / 胸部CT / 生化学マーカー / 検診 / コホート研究 / 石綿関連疾患 / じん肺 / 肝細胞癌 / HBV DNA組込み / 染色体異常 / トランスフェクション / 発癌遺伝子 / X抗原・抗体系 / B型肝炎ウィルス / ウッドチャック肝炎ウィルス / Transfection系 / 肝炎ウイルスエンハンサーlca遺伝子 / Transgenic Mouse / ウッドチャク肝炎ウイルス / HBV / DNA組み込み / ダックB型肝炎ウイルス / ウッドチャック肝癌 / cMyc遺伝子 / 癌遺伝子1ca / ウッドチャック肝炎ウイルス / ウィルムス腫瘍 / ネフロジエ-ニック・レスト / 動物モデル / 腎移植 / ウイルスム腫瘍 / ENU / 化学発癌 / 前駆病変 / WT1 / 腎腫瘍 / 前癌病変 / 癌制御遺伝子 / WT1遺伝子 / Wilms tumor / nephrogenic rest / animal model / renal transplantaion / 脳死 / 臓器移植 / クローン技術 / ヒト胚性幹細胞 / エンハンスメント / 宗教文化 / スピリチュアリティ / <いのち>の尊厳 / 死 / ターミナルケア / スピリチュアルケア / インハーンスメント / 遺伝子治療 / 新生児集中治療 / 生命倫理の日米比較 / ヒトES細胞 / 生命倫理 / 再生医療 / 幹細胞 / 国際宗教学宗教史学会 / 死生観 / スリランカ / インド / いのち / 人胚研究 / クローン / 人工生殖 / 生命科学 / Brain Death / Organ Transplantation / Cloning / Embryonic Stem Cells / Enhancement / Religious Cultures / Spirituality / Sanctity of Life / 細胞内情報伝達 / 免疫組織化学 / Westernブロッティング / 腫瘍 / 過誤組織 / 形成異常 / 皮質結節 / モデル動物 / 神経病理 / Tuberous sclerosis complex / Intracellular signal transduction / Immunohistochemistry / Western blotting / Neoplasia / Dysplasia / 悪性中皮腫 / 腫瘍診断 / mesothelin / PET / Mesothelin遺伝子 / Erc遺伝子 / Mesothelin gene / Tsc2 gene / GPI anchor protein / knockout mouse / Carcinogenesis / ゲノム不安定性 / アシルCoA合成酵素 / 脂肪酸代謝 / hepatocarcinogenesis / genomic instability / 女性がん患者の葛藤 / 母娘の関係性 / 気遣い / 母親の不安 / 子供の不安 / がんサバイバー / 女性 / 母親役割 / 癌 / 社会系心理学 / がん教育 / 学校薬剤師 / 学習指導要領 / がん対策基本法 Less

Development of cancer education system in cooperation with school pharmacists in the regionOngoing
- Principal Investigator
  
  沼田千賀子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09040:Education on school subjects and primary/secondary education-related
- Research Institution
  Kobe Pharmaceutical University
Establishment of "cancer education and dialogue" based on "cancer philosophy"Principal Investigator
- Principal Investigator
  
  Hino Okio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Developmental mechanisms and the body works
- Research Institution
  Juntendo University
母親役割をもつがんサバイバーが子供に病状説明をする際に生じる心理的葛藤と意志決定Ongoing
- Principal Investigator
  
  栗原明美
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Lifelong developmental nursing
- Research Institution
  Juntendo University
Rehabilitation of cancer cellsPrincipal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Risk assessment of asbestos-related diseases among construction workers
- Principal Investigator
  
  SUGANUMA Narufumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Kochi University
Rehabilitation of cancer cellsPrincipal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Risk evaluation of environmental carcinogenesisPrincipal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cancer epidemiology and prevention
- Research Institution
  Juntendo University
The mechanism of loss of Erc gene ameliorates renal carcinogenesis and modulates integrin related pathway
- Principal Investigator
  
  ZHANG Danqing
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Juntendo University
Development of asbestos related tumor marker using protein array methods
- Principal Investigator
  
  SUGANUMA Narufumi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Kochi University
The functional analysis of Erc gene encoding GPI anchor protein
- Principal Investigator
  
  ZHANG Danqing
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Juntendo University
Role of dbpA in hepatocarcinogenesis
- Principal Investigator
  
  KAJINO Kazunori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University
The study of multistep carcinogenesis using unique animal modelsPrincipal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Experimental pathologic study on the pathogenesis of cerebral lesions in tuberous sclerosis
- Principal Investigator
  
  MIZUGUCHI Masashi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
アスベスト暴露に伴う悪性中皮腫の早期診断法の開発
- Principal Investigator
  
  辻井博彦
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Special Purposes
- Research Institution
  National Institute of Radiological Sciences
Molecular mechanism of hypercarcinogenic state -inflammation-induced hepatocarcinogenesis-Principal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  JUNTENDO UNIVERSITY
Research on Brain Death and Organ Transplantation from the Perspective of Comparative Religion
- Principal Investigator
  
  MACHIDA Soho
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Religious studies
- Research Institution
  Tokyo University of Foreign Studies
Multi-step carcinogenesis using genetically retired modelsPrincipal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University School of Medfcine
  Japanese Foundation For Cancer Research
ヨーロッパなどががん研究先進国との研究交流
- Principal Investigator
  
  黒木登志夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Showa University
Multistage carcinogenesis in TSC gene mutant modelsPrincipal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Cancer Institute Carcinogenesis
Pathogenesis of Human Tuberous SclerosisPrincipal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Cancer Institute
ラット実験腫瘍の染色体遺伝子背景についての研究
- Principal Investigator
  
  吉田廸弘
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
遺伝性腎癌ラットの発癌機構の解明Principal Investigator
- Principal Investigator
  
  樋野興夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
Experimental study of Wilms tumor and its precursor lesion "nephrogenic rest" by using animal models.
- Principal Investigator
  
  YOKOMORI Kinji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  小児外科
- Research Institution
  The University of Tokyo
ラット実験腫瘍の染色体遺伝子背景についての研究
- Principal Investigator
  
  杉山武敏
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
化学発癌における前癌病変、潜在癌および顕在癌の特性に関する分子病理学的研究
- Principal Investigator
  
  伊東信行
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya City University
遺伝子導入動物による発癌の研究Principal Investigator
- Principal Investigator
  
  樋野興夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinomaPrincipal Investigator
- Principal Investigator
  
  HINO Okio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Cancer Institute
ラット実験腫瘍の染色体遺伝子背景についての研究
- Principal Investigator
  
  杉山武敏
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
遺伝子導入動物による発症の研究
- Principal Investigator
  
  山村研一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
化学発癌における前癌病変、潜在癌および顕在癌の特性に関する分子病理学的追求
- Principal Investigator
  
  伊東信行
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University
遺伝性腎癌ラット繁殖システムの確立と発癌機構の解明Principal Investigator
- Principal Investigator
  
  樋野興夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
遺伝子導入動物による発癌の研究
- Principal Investigator
  
  YAMAMURA Kenichi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kumamoto University
前癌病変、潜在癌および顕在癌の特性に関する分子病理学的追求
- Principal Investigator
  
  伊東信行
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University
肝癌発生過程におけるgenomic instabilityの分子機構の解明Principal Investigator
- Principal Investigator
  
  樋野興夫
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Japanese Foundation For Cancer Research
肝炎ウイルスと肝癌発生
- Principal Investigator
  
  服部信
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
B型肝炎ウイルスによる肝発癌の解析
- Principal Investigator
  
  北川知行
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
肝炎ウイルスと肝癌発生
- Principal Investigator
  
  服部信
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
B型肝炎ウィルスによる肝発癌の解析
- Principal Investigator
  
  北川知行
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
B型肝炎ウイルスによる肝発癌の解析
- Principal Investigator
  
  北川知行
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
アメリカ大陸を中心としてがん研究先進グループとの研究交流
- Principal Investigator
  
  河井貞明
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Overseas Scientific Research
- Research Institution
  The University of Tokyo
B型肝炎ウイルスの宿主DNAへの組込みと肝癌発生
- Principal Investigator
  
  服部信
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kanazawa University
B型肝炎ウイルスと肝発癌
- Principal Investigator
  
  北川知行
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Japanese Foundation For Cancer Research

[Book] われ21世紀の新渡戸とならん2018
- Author(s)
  樋野興夫
- Total Pages
  93
- Publisher
  イーグレープ
- ISBN
  9784909170040
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 大切な人ががんになったとき…生きる力を引き出す寄り添い方2018
- Author(s)
  樋野興夫
- Total Pages
  208
- Publisher
  青春出版社
- ISBN
  4413211146
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 楕円形のこころ2018
- Author(s)
  樋野興夫
- Total Pages
  148
- Publisher
  春秋社
- ISBN
  4393716337
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] がんばりすぎない、悲しみすぎない。　「がん患者の家族」のための言葉の処方箋2017
- Author(s)
  樋野　興夫
- Total Pages
  194
- Publisher
  講談社
- ISBN
  9784062206150
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] いい人生は、最期の５年で決まる2017
- Author(s)
  樋野興夫
- Total Pages
  176
- Publisher
  SBクリエイティブ
- ISBN
  9784797389616
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 苦しみを癒す「無頓着」のすすめ2017
- Author(s)
  樋野　興夫
- Total Pages
  212
- Publisher
  ブックマン社
- ISBN
  9784893088758
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 人生から期待される生き方2017
- Author(s)
  樋野興夫
- Total Pages
  208
- Publisher
  主婦の友社
- ISBN
  9784074229079
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 人の心に贈り物を残していく2017
- Author(s)
  樋野興夫、柳田邦男
- Total Pages
  256
- Publisher
  悟空出版
- ISBN
  9784908117336
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 「あなたはそこにいるだけで価値ある存在」2016
- Author(s)
  樋野興夫
- Total Pages
  207
- Publisher
  KADOKAWA
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 「今日」という日の花を摘む2016
- Author(s)
  樋野興夫
- Total Pages
  256
- Publisher
  実業之日本社
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 「病気は人生の夏休み」2016
- Author(s)
  樋野興夫
- Total Pages
  199
- Publisher
  幻冬舎
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] 「がん哲学外来へようこそ」2016
- Author(s)
  樋野興夫
- Total Pages
  192
- Publisher
  新潮社
- Data Source
  KAKENHI-PROJECT-16K12983
[Book] Models for genitourinary cancer-Hereditary renal carcinogenesis. The CANCER handbook. Second edition.2007
- Author(s)
  Hino, O.
- Publisher
  WILEY
- Data Source
  KAKENHI-PROJECT-17013076
[Book] Cancer : Cell Structures, Carcinogens and Genomic Instability.2006
- Author(s)
  Hino O., Kobayashi T., Okimoto K.
- Total Pages
  24
- Publisher
  Birkhauser Verlag
- Data Source
  KAKENHI-PROJECT-17013076
[Book] Cancer : Cell Structures, Carinogenes and Genomic Instability.2005
- Author(s)
  Hino O., Kobayashi T., Okimoto K.
- Publisher
  Birkhauser Verlag
- Data Source
  KAKENHI-PROJECT-17013076
[Book] In New Perspectives in Cancer Research and Therapy. (Edited Shigeki Kuriyama and Hitoshi Yoshiji)2005
- Author(s)
  Hino O.
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-16390121
[Book] New Perspectives in Cancer Research and Therapy2005
- Author(s)
  Hino, O.
- Total Pages
  6
- Publisher
  Research Signpost
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Book] Philosophy of Cancer : Viewing the Conditions of Human Society from the Cancer Cell2004
- Author(s)
  Okio Hino
- Total Pages
  106
- Publisher
  to be shuppan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14310014
[Book] がん哲学がん細胞から人間社会の病理を見る2004
- Author(s)
  樋野興夫
- Total Pages
  106
- Publisher
  to be 出版
- Data Source
  KAKENHI-PROJECT-14310014
[Book] Gann Monograph on Cancer Research2004
- Author(s)
  Hino O.et al.
- Total Pages
  15
- Publisher
  2004 Japan Scientific Societies Press.
- Data Source
  KAKENHI-PROJECT-12213139
[Book] がん哲学がん細胞から人間社会の病理を見る2004
- Author(s)
  樋野興夫
- Total Pages
  106
- Publisher
  to be出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14310014
[Book] Gann Monograph on Cancer Research2004
- Author(s)
  Hino O.et al.
- Total Pages
  15
- Publisher
  2004 Japan Scientific Societies Press.
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Ammonium tetrathiomolybdate enhances the antitumor effects of cetuximab via the suppression of osteoclastogenesis in head and neck squamous carcinoma.2018
- Author(s)
  Okura H, Kobayashi T, Zhang D, Hino O, et al
- Journal Title
  
  Int J Oncol.
  
  Volume: 2 Pages: 1489-1500
- DOI
  10.3892/ijo
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22500389, KAKENHI-PROJECT-22590282, KAKENHI-PROJECT-22590738, KAKENHI-PROJECT-22790335, KAKENHI-PUBLICLY-23112514, KAKENHI-PROJECT-23390140, KAKENHI-PROJECT-23390199, KAKENHI-PROJECT-23659617, KAKENHI-PROJECT-23790050, KAKENHI-PLANNED-24108006, KAKENHI-PROJECT-24500484, KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24510065, KAKENHI-PROJECT-24701023, KAKENHI-PROJECT-25861745, KAKENHI-PROJECT-26430207, KAKENHI-PROJECT-16K09561, KAKENHI-PROJECT-17K17895
[Journal Article] Psychological transition characteristics of patients diagnosed with asbestos-related mesothelioma.2018
- Author(s)
  Kasai Y., Hino O.
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 64 Pages: 114-121
- NAID
  130007397832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K12983
[Journal Article] Clinical impacts of mesothelin expression in gastrointestinal carcinomas.2016
- Author(s)
  Einama T., Kawamata F., Kamachi H., Nishihara H., Homma S., Matsuzawa F., Mizukami T., Konishi Y., Tahara M., Kamiyama T., Hino O., Taketomi A., Todo S.
- Journal Title
  
  World J. Gastrointestinal Pathophysiology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo2016
- Author(s)
  Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa T, Kataoka Y, Yamamura K.
- Journal Title
  
  Sci. Reports
  
  Volume: 5 Pages: 17205-17205
- DOI
  10.1038/srep17205
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08259, KAKENHI-PUBLICLY-15H00905, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25460399
[Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer.2016
- Author(s)
  Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 22 Pages: 557-566
- DOI
  10.3748/wjg.v22.i2.557
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] The effects of URA1/SLC22A12 nonfunctional variants, R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression.2016
- Author(s)
  Sakiyama M, Matsuo H, Shimizu S et al.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 20148-20148
- DOI
  10.1038/srep20148
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461244, KAKENHI-PROJECT-15K15227, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25293145, KAKENHI-PROJECT-15H04315, KAKENHI-PROJECT-16K10181
[Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway.2016
- Author(s)
  Kurihara H, Maruyama R, Ishiguro K, Kanno S, Yamamoto I, Ishigami K, Mitsuhashi K, Igarashi H, Ito M, Tanuma T, Sukawa Y, Okita K, Hasegawa T, Imai K, Yamamoto H, Shinomura Y, Nosho K.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 11 Pages: 12704-120717
- DOI
  10.18632/oncotarget.7260
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-16K07145, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Changes of tryptophan metabolism in Japanese runners during an ultramarathon race.2016
- Author(s)
  Yamada N, Shibata K, Fuku M, Kuriki K, Goto G, Tokudome Y, Miyata M, Maeda K, Hoshino H, Suzuki S, Marumoto M, Ichikawa H, Agawa H, Ishikawa N, Arakawa K, Hosono A, Kobayashi M, Tokudome S.
- Journal Title
  
  Sport Sci Health
  
  Volume: 12 Pages: 77-83
- DOI
  10.1007/s11332-016-0257-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Contextual niche signals towards colorectal tumor progression by mesenchymal stem cell in the mouse xenograft model2015
- Author(s)
  Nakagaki S, Arimura Y, Nagaishi K, Isshiki H, Nasuno M, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y
- Journal Title
  
  J Gastroenterol
- Description
  【掲載確定】 Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis2015
- Author(s)
  Mitsuhashi K, Nosho K, Sukawa Y, Matsunaga Y, Ito M, Kurihara H, Kanno S, Igarashi H, Naito T, Adachi Y, Tachibana M, Tanuma T, Maguchi H, Shinohara T, Hasegawa T, Imamura M, Kimura Y, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
- Journal Title
  
  Oncotarget
- Description
  【掲載確定】 in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients.2015
- Author(s)
  Nosho K, Igarashi H, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yoshii S, Mikami M, Takahashi H, Kusumi T, Hosokawa M, Sukawa Y, Adachi Y, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
- Journal Title
  
  Digestion
  
  Volume: 91(1) Issue: 1 Pages: 57-63
- DOI
  10.1159/000368820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25293289
[Journal Article] Low-frequency IL23R coding variant associated with Crohn’s disease susceptibility in Japanese subjects identified by personal genomics analysis.2015
- Author(s)
  Onodera K, Arimura Y, Isshiki H, Kawakami K, Nagaishi K, Yamashita K, Yamamoto E, Niinuma T, Naishiro Y, Suzuki H, Imai K, Shinomura Y
- Journal Title
  
  Plos One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0137801
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08972, KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-26460975, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25460954, KAKENHI-PROJECT-25460955, KAKENHI-PROJECT-26640101
[Journal Article] Role of interleukin-32 in the mechanism of chronic inflammation in IgG4-related disease and as a predictive biomarker for drug-free remission.2015
- Author(s)
  Shimizu Y, Yamamoto M, Yajima H, Suzuki C, Naishiro Y, Takahashi H, Imai K, Shinomura Y.
- Journal Title
  
  Modern Rheumatology
  
  Volume: 26(3) Pages: 391-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway.2015
- Author(s)
  Ito M, Kanno S, Nosho K, Sukawa Y, Mitsuhashi K, Kurihara H, Igarashi H, Takahashi T, Tachibana M, Takahashi H, Yoshii S, Takenouchi T, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 137 Pages: 1258-1268
- DOI
  10.1002/ijc.29488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-26640101
[Journal Article] A potential function for neuronal exosomes : sequestering intracerebral amyloid-beta peptide2015
- Author(s)
  Yuyama, K., Sun, H., Usuki, S., Sakai, S., Hanamatsu, H., Mioka, T., Kimura, N., Okada, M., Tahara, H., Furukawa, J., Fujitani, N., Shinohara, Y. & Igarashi, Y.
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Pages: 84-8
- DOI
  10.1016/j.febslet.2014.11.027
- NAID
  120005537475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-25290039, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-221S0001
[Journal Article] Establishment of Tsc2-deficient rat embryonic stem cells2015
- Author(s)
  Ito Y., Kawano H., Kanai F., Nakamura E., Tada N., Takai S., Horie S., Arai H., Kobayashi T. & Hino O.
- Journal Title
  
  Int J Oncol
  
  Volume: 46 Pages: 1944-1952
- DOI
  10.3892/ijo.2015.2913
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670196, KAKENHI-PROJECT-26460398, KAKENHI-PROJECT-221S0001
[Journal Article] NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout2015
- Author(s)
  Chiba T, Matsuo H, Kawamura Y, Nagamori S, Nishiyama T, Wei L, Nakayama A, Nakamura T, Sakiyama M, Takada T, Taketani Y, Suma S, Naito M, Oda T, Kumagai H, Moriyama Y, Ichida K, Shimizu T, Kanai Y, Shinomiya N.
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 67(1) Pages: 281-287
- DOI
  10.1002/art.38884
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590702, KAKENHI-PROJECT-23689008, KAKENHI-PROJECT-24390217, KAKENHI-PROJECT-24591198, KAKENHI-PUBLICLY-25136714, KAKENHI-PROJECT-25293145, KAKENHI-PROJECT-25670307, KAKENHI-PROJECT-26461244, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04315, KAKENHI-PROJECT-25253008
[Journal Article] Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy.2015
- Author(s)
  Mitsuhashi K, Yamamoto I, Kurihara H, Kanno S, Ito M, Igarashi H, Ishigami K, Sukawa Y, Tachibana M, Takahashi H, Tokino T, Maruyama R, Suzuki H, Imai K, Shinomura Y, Yamamoto H, Nosho K
- Journal Title
  
  Oncotarget
  
  Volume: 6 Pages: 22114-22125
- DOI
  10.18632/oncotarget.4294
- NAID
  130005161488
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
[Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadentist: Result from the SMART database.2015
- Author(s)
  Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
- Journal Title
  
  Modern Rheumatology
  
  Volume: 27 Pages: 199-204
- DOI
  10.3109/14397595.2014.950036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861575, KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
[Journal Article] Minimal inflammogenicity of pristine single-wall carbon nanotubes2015
- Author(s)
  Toyokuni, S.
- Journal Title
  
  Nagoya J Med Sci
  
  Volume: 5
- DOI
  10.3389/fphar.2014.00200
- NAID
  120005549565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Low FOXA1 expression predicts good response to neo-adjuvant chemotherapy resulting in good outcomes for luminal HER2-negative breast cancer cases2015
- Author(s)
  Horimoto, Y., Arakawa A., Harada-Shoji N., Sonoue H., Yoshida Y., Himuro T., Igari F., Tokuda E., Mamat O., Tanabe M., Hino O. and Saito M.
- Journal Title
  
  Br J Cancer
  
  Volume: 112
- DOI
  10.1038/bjc.2014.595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.2015
- Author(s)
  Hiroko Sugiura, Shin Yasuda, Shutaro Katsurabayashi, Hiroyuki Kawano, Kentaro Endo, Kotaro Takasaki, Katsunori Iwasaki, Masumi Ichikawa, Toshiyuki Kobayashi, Okio Hino and Kanato Yamagata
- Journal Title
  
  Nature Commun.
  
  Volume: 6 Pages: 6842-6842
- DOI
  10.1038/ncomms7842
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659093, KAKENHI-PUBLICLY-25110737, KAKENHI-PROJECT-25293239, KAKENHI-PROJECT-25350988, KAKENHI-PROJECT-25670196, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-24500452
[Journal Article] Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer.2015
- Author(s)
  Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 14 Pages: 2640-2648
- DOI
  10.1245/s10434-014-4264-7
- Description
  Epub ahead of print
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670371, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-26293290
[Journal Article] Minimal inflammogenicity of pristine single-wall carbon nanotubes.2015
- Author(s)
  Toyokuni S, Jiang L, Kitaura R and Shinohara S.
- Journal Title
  
  Nagoya J Med Sci
  
  Volume: 77 Pages: 195-202
- NAID
  120005549565
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Environmental carcinognensis-100th anniversary of creating cancer.2015
- Author(s)
  Misa Imai, Okio Hino
- Journal Title
  
  Cancer Science
  
  Volume: 106 Pages: 1483-1485
- DOI
  10.1111/cas.12798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26861341, KAKENHI-PROJECT-221S0001
[Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.2015
- Author(s)
  Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
- Journal Title
  
  Oncotarget.
  
  Volume: 6 Pages: 29975-29990
- DOI
  10.18632/oncotarget.5034
- NAID
  130005161526
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K18431, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-26640101
[Journal Article] Cotyledonoid dissecting leiomyoma of the uterus : report of two cases2015
- Author(s)
  Saeki, H., Suzuki C., Yamasaki S., Hashizume A., Izumi H., Suzuki F., Ishi K., Nojima M. and Hino O.
- Journal Title
  
  Arch Gynecol Obstet
  
  Volume: 291
- DOI
  10.1007/s00404-014-3406-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer2014
- Author(s)
  Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
- Journal Title
  
  Annals of Surgical Oncology
- Description
  Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Cancer Philosophy～Thinking“Cancer Cells”Deeply2014
- Author(s)
  Hino, O
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Coffee and green tea consumption is associated with upper aerodigestive tractcancer in Japan2014
- Author(s)
  Oze I, Matsuo K, Kawakita D, Hosono S, Ito H, Watanabe M, Hatooka S, Hasegawa Y, Shinoda M, Tajima K, Tanaka H.
- Journal Title
  
  Int J Cancer
  
  Volume: 135 Issue: 2 Pages: 391-400
- DOI
  10.1002/ijc.28653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860430, KAKENHI-PROJECT-221S0001
[Journal Article] IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions2014
- Author(s)
  Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20(29) Issue: 29 Pages: 10050-61
- DOI
  10.3748/wjg.v20.i29.10050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] Epstein-Barr virus-infected cells in IgG4-related lymphadenopathy with comparison to extranodal IgG4-related disease2014
- Author(s)
  Takeuchi M, Sato Y, Yasui H, Ozawa H, Ohno K, Takata K, Gion Y, Orita Y, Tachibana T, Itoh T, Asano N, Nakamura S, Swerdlow SH, Yoshino T.
- Journal Title
  
  Am J Surg Pathol
  
  Volume: － Pages: 946-955
- DOI
  10.1097/pas.0000000000000206
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591402, KAKENHI-PROJECT-24591447, KAKENHI-PROJECT-26293078, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] Utility of PAX8 mouse monoclonal antibody in the diagnosis of thyroid, thymic, pleural and lung tumours : a comparison with polyclonal PAX8 antibody2014
- Author(s)
  Toriyama A, Mori T, Sekine S, Yoshida A, Hino O, Tsuta K.
- Journal Title
  
  Histopathology.
  
  Volume: On line Pages: 465-472
- DOI
  10.1111/his.12405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-25670868, KAKENHI-PROJECT-26460463, KAKENHI-PROJECT-221S0001
[Journal Article] Radiographic Progression of Silicosis among Japanese Tunnel Workers in Kochi.2014
- Author(s)
  Narongpon Dumavibhat, Tomomi Matsui, Eri Hoshino, Sasivimol Rattanasiri, Dittapol Muntham, Ryoji Hirota, Masamitsu Eitoku, Momo Imanaka, Basilua Andre Muzembo, Nlandu Roger Ngatu, Shinichi Kondo, Norihiko Hamada, Narufumi Suganuma
- Journal Title
  
  Journal of Occupational Health
  
  Volume: -
- NAID
  10031159406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390154
[Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma.2014
- Author(s)
  Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y
- Journal Title
  
  Tumor Biol
  
  Volume: 35 Issue: 2 Pages: 973-85
- DOI
  10.1007/s13277-013-1131-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-24650632, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] Rat N-ERC/mesothelin as a marker for in vivo screening of drugs against pancreas cancer.2014
- Author(s)
  Fukamachi K, Iigo M, Hagiwara Y, Shibata K, Futakuchi M, Alexander DB, Hino O, Suzui M, Tsuda H.
- Journal Title
  
  Plos One
  
  Volume: 9 Pages: 268-274
- DOI
  10.1371/journal.pone.0111481
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590469, KAKENHI-PROJECT-24501319, KAKENHI-PROJECT-25430154, KAKENHI-PROJECT-26460476, KAKENHI-PROJECT-221S0001
[Journal Article] Identification of immunogenic LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes and eliciting CD4+ T-cell immunity in patients with malignant disease2014
- Author(s)
  Tomita, Y.*, Yuno, A.*, Tsukamoto, H., Senju, S., Kuroda, Y., Hirayama, M., Imamura, Y., Yatsuda, J., Sayem, M. A., Irie, A., Hamada A., Jono, H., Yoshida, K., Tsunoda, T, Daigo, Y., Kohrogi, H., Yoshitake, Y., Nakamura,Y., Shinohara, M., Nishimura, Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: 3
- DOI
  10.4161/onci.28100
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22133005, KAKENHI-PROJECT-24300334, KAKENHI-PROJECT-26460972, KAKENHI-PROJECT-221S0001
[Journal Article] A common variant of organic anion transporter 4(OAT4/SLC22A11) gene is associated with renal underexcretion type gout2014
- Author(s)
  Sakiyama, M., Matsuo H., Shimizu S., Nakashima H., Nakayama A., Chiba T., Naito M., Takada T., Suzuki H., Hamajima N., Ichida K., Shimizu T. and Shinomiya N.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 29
- NAID
  130004463357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality2014
- Author(s)
  Shiono M., Kobayashi T., Takahashi R., Ueda M., Ishikawa C. and Hino O.
- Journal Title
  
  Sci Rep
  
  Volume: 4 Pages: 5927-5927
- DOI
  10.1038/srep05927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670196, KAKENHI-PROJECT-221S0001
[Journal Article] Mesenchymal stem cells cancel azoxymethane-induced tumor initiation.2014
- Author(s)
  Nasuno M, Arimura Y, Nagaishi K, Isshiki H, Onodera K, Nakagaki S, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y
- Journal Title
  
  STEM CELLS
  
  Volume: 32 Issue: 4 Pages: 913-25
- DOI
  10.1002/stem.1594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-24650632, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-25460954, KAKENHI-PROJECT-25460955, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] Ethnic Differences in ATP-binding Cassette Transporter, Sub-family G, Member 2 (ABCG2/BCRP): Genotype Combinations and Estimated Functions2014
- Author(s)
  Sakiyama M, et al.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 29(6) Issue: 6 Pages: 490-2
- DOI
  10.2133/dmpk.dmpk-14-sc-041
  10.2133/dmpk.DMPK-14-SC-041
- NAID
  130004463408
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23689008, KAKENHI-PROJECT-25293145, KAKENHI-PROJECT-25670307, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-221S0002
[Journal Article] Asbestos-related mesothelioma : Prevention, early detection, treatment2014
- Author(s)
  Imai, M. and Hino O.
- Journal Title
  
  JSM Clinical Oncology and Research
  
  Volume: 2 Issue: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.2014
- Author(s)
  Ito M, Mitsuhashi K, Igarashi H, Nosho K, Yamamoto H
- Journal Title
  
  International Journal of Cancer
  
  Volume: (Epub ahead of print) Issue: 11 Pages: 2507-15
- DOI
  10.1002/ijc.28920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer2014
- Author(s)
  Harada T, Yamamoto E, Yamano HO, Nojima M, Maruyama R, Kumegawa K, Ashida M, Yoshikawa K, Kimura T, Harada E, Takagi R, Tanaka Y, Aoki H, Nishizono M, Nakaoka M, Tuyada A, Niinuma T, Kai M, Shimoda K, Shinomura Y, Sugai T, Imai K, Suzuki H.
- Journal Title
  
  Cancer Prevention Research (Philadelphia, Pa.)
  
  Volume: 7(10) Issue: 10 Pages: 1002-10
- DOI
  10.1158/1940-6207.capr-14-0162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] Database for exchangeable gene trap clones : Pathway and gene ontology analysis of exchangeable genetrap clone mouse lines2014
- Author(s)
  Araki, M., Nakahara, M., Muta, M., Itou, M., Yanai, C., Yamazoe, F., Miyake, M., Morita, A., Araki, M., Okamoto, Y., Nakagata, M., Yoshinobu, K., Yamamura, K. and Araki, K.
- Journal Title
  
  Develop. Growth Differ
  
  Volume: 56 Pages: 161-174
- DOI
  10.1111/dgd.12116
- NAID
  40019987325
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-25430092, KAKENHI-PROJECT-221S0001
[Journal Article] Retrospective analysis of large-scale research screening of construction workers for the early diagnosis of mesothelioma2014
- Author(s)
  Hirohashi T, Igarashi K, Abe M, Hino O et al.
- Journal Title
  
  Mol Clin Oncol
  
  Volume: 2 Pages: 26-30
- DOI
  10.3892/mco.2013.197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma.2014
- Author(s)
  Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A, Todo S
- Journal Title
  
  Journal of gastroenterology
  
  Volume: 49 Pages: 81-92
- DOI
  10.1007/s00535-013-0773-6
- NAID
  120005537455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590435, KAKENHI-PROJECT-24590469, KAKENHI-PROJECT-221S0001
[Journal Article] Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia : a pooled analysis of 21 cohorts2014
- Author(s)
  Zheng, W., McLerran D.F., Rolland B.A., Fu Z., Boffetta P., Tsugane S., Irie F., Tamakoshi A., Shu X.O., Ozasa K., Nishino Y., Tsuji I., Tanaka H., Sawada N., Ohishi W., Kakizaki M., Watanabe T., Oze I., Sugawara Y., Matsuo K., et al.
- Journal Title
  
  PLoS Med
  
  Volume: 11
- DOI
  10.1371/journal.pmed.1001631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages.2014
- Author(s)
  Watari K, Shibata T, Kawahara A, Sata K, Nabeshima H, Shinoda A, Abe H, Azuma K, Murakami Y, Izumi, H, Takahashi T, Kage M, Kuwano M, Ono M.
- Journal Title
  
  PLoS One
  
  Volume: 9
- DOI
  10.1371/journal.pone.0099568
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134005, KAKENHI-PROJECT-23300350, KAKENHI-PROJECT-25830083, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25250017
[Journal Article] ERC/mesothelin is expressed in human gastric cancer tissues and cell lines2014
- Author(s)
  Ito T, Kajino K, Abe M, Hino O et al.
- Journal Title
  
  Oncol Rep
  
  Volume: 31 Pages: 27-33
- DOI
  10.3892/or.2013.2803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Rheb-syntenin interaction regulates dendritic spine formation in rodent models of tuberous sclerosis.2014
- Author(s)
  285. Sugiura H., Yasuda S., Katsurabayashi S., Oguri K., Tanaka H., Takasaki K., Iwasaki K., Kobayashi T., Hino O. and Yamagata K.
- Journal Title
  
  PNAS
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670196
[Journal Article] Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma2014
- Author(s)
  Sato, T., Suzuki Y., Mori T., Maeda M., Abe M., Hino O. and Takahashi K.
- Journal Title
  
  Cancer Med
  
  Volume: 3
- DOI
  10.1002/cam4.297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Decreased amyloid-beta Pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice2014
- Author(s)
  Yuyama, K., Sun, H., Sakai, S., Mitsutake, S., Okada, M., Tahara, H., Furukawa, J., Fujitani, N., Shinohara, Y. & Igarashi, Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Pages: 24488-24498
- DOI
  10.1074/jbc.m114.577213
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106, KAKENHI-PROJECT-26440041, KAKENHI-PROJECT-26450162, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-221S0001
[Journal Article] Activation of Rheb, but not of MTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.2014
- Author(s)
  Yasuda S, Sugiura H, Katsurabayashi S, Shimada T, Tanaka H, Takasaki K, Iwasaki K, Kobayashi T, Hino O, Yamagata K.
- Journal Title
  
  Science Rep.
  
  Volume: 4 Pages: 5155-5155
- DOI
  10.1038/srep05155
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590300, KAKENHI-PROJECT-24500452, KAKENHI-PROJECT-24659093, KAKENHI-PROJECT-24700349, KAKENHI-PUBLICLY-25110737, KAKENHI-PROJECT-25293239, KAKENHI-PROJECT-25350988, KAKENHI-PROJECT-25670196, KAKENHI-PROJECT-221S0001
[Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer2013
- Author(s)
  Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 11 Pages: 937-951
- DOI
  10.1158/1541-7786.mcr-12-0685-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650624, KAKENHI-PROJECT-23659433, KAKENHI-PROJECT-24390145, KAKENHI-PROJECT-25253057, KAKENHI-PROJECT-221S0001
[Journal Article] TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity2013
- Author(s)
  Osawa M., Kobayashi T., Okura H., Igarashi T., MizuguchiM. and Hino O
- Journal Title
  
  Plos One
  
  Volume: 8 Pages: 1-13
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Up-regulation of dbpA mRNA in hepatocellular carcinoma associated with metabolic syndrome2013
- Author(s)
  Obulhasim G., Yasen M., Kajino K., Mogushi K., Tanaka S., Mizushima H., Tanaka H., Arii S. and Hino O
- Journal Title
  
  Hepatol. Int
  
  Volume: 7 Pages: 215-225
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway.2013
- Author(s)
  Okura H, Kobayashi T, Koike M, Ohsawa M, Zhang D, Arai H, Uchiyama Y, Hino O.
- Journal Title
  
  Int. J. Oncology
  
  Volume: 43 Pages: 447-456
- DOI
  10.3892/ijo.2013.1984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-25670196
[Journal Article] Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.2013
- Author(s)
  Abe H., Mochizuki S., Ohara K., Ueno M., Ohiai H., Kitagawa Y., Hino O., Sato H. and Okada Y.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 183 Pages: 1667-1678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670196
[Journal Article] The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma.2013
- Author(s)
  Mori T, Tajima K, Hirama M, Hino O et al.
- Journal Title
  
  Journal of thoracic disease
  
  Volume: 5 Pages: 145-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Mesothelin expression is a prognostic factor in cholangiocellular carcinoma.2013
- Author(s)
  Nomura R, Fujii H, Abe M, Hino O et al.
- Journal Title
  
  International surgery
  
  Volume: 98 Pages: 164-169
- DOI
  10.9738/intsurg-d-13-00001.1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity.2013
- Author(s)
  Ohsawa M, Kobayashi T, Hino O, et al
- Journal Title
  
  Plos One
  
  Volume: 8(1)
- DOI
  10.1371/journal.pone.0054503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389, KAKENHI-PROJECT-24659490, KAKENHI-PROJECT-25670196
[Journal Article] Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15 nm in diameter does not induce mesothelial carcinogenesis in rats2013
- Author(s)
  H.Nagai
- Journal Title
  
  Pathol Int
  
  Volume: 63 Pages: 457-462
- DOI
  10.1111/pin.12093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22225001, KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24390094, KAKENHI-PROJECT-25860292, KAKENHI-PROJECT-221S0001
[Journal Article] NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in breast carcinoma MCF7/mitoxantrone-resistant cells via a caspase-independent pathway2013
- Author(s)
  Ito M., Kajino K., Abe M., Fujimura T., Mineki R., Ikegami T., Ishikawa T. and Hino O
- Journal Title
  
  Oncology Reports
  
  Volume: 29 Pages: 1492-1500
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Improved PCR amplification for molecular analysis using DNA from long-term preserved formalin-fixed, paraffin-embedded lung cancer tissue specimens.2013
- Author(s)
  Taga M, Eguchi H, Shinohara T et al.
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 6 Pages: 76-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.2013
- Author(s)
  Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: [Epub ahead of print]
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Folliculin regulates cyclin D1 expression through cis-acting elements in the 3' untranslated region of cyclin D1 mRNA2013
- Author(s)
  Kawai A, Kobayashi T, Hino O
- Journal Title
  
  Int J Oncol
  
  Volume: 42(5) Pages: 1597-604
- DOI
  10.3892/ijo.2013.1862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] The utility of serum N-ERC/mesothelin as biomarker of ovarian carcinoma2012
- Author(s)
  Saeki H., Hashizume A., Izumi H., Suzuki F., Ishi K., Nojima M., Maeda M. and Hino O.
- Journal Title
  
  Oncology Letters
  
  Volume: 4 Pages: 637-641
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex2012
- Author(s)
  Sato A., Kasai S., Kobayashi T., Takamatsu Y., Hino O., Ikeda K. and Mizuguchi M
- Journal Title
  
  Nature Communications
  
  Volume: 2295 Pages: 1-9
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen.2012
- Author(s)
  Miyanaga N, et al
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 125-130
- DOI
  10.1111/j.1349-7006.2011.02120.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] DNA binding protein A exression and methylation status in hepatocellular carcinoma and the adjacent tissue2012
- Author(s)
  Yasen M., Obulhasim G., Kajino K., Mogushi K., Mizushima H., Tanaka S., Tanaka H., Hino O. and Arii S
- Journal Title
  
  Int. J. Oncology
  
  Volume: 40 Pages: 789-797
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Model of translational cancer research in multiple myeloma.2012
- Author(s)
  Yasui H, Ishida T, Maruyama R, Nojima M, Ikeda H, Suzuki H, Hayashi T, Shinomura Y, Imai K.
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 1207-1212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Preventing of alveolar destruction and airspace enlargement in a mouse Model of pulmonary lymphangioleiomyomatosis (LAM)2012
- Author(s)
  Goncharova E.A., Goncharov D.A., Fehrenbach M., Khavin I., Ducka B., Hino O., Colby T.V., Merrilees M.J., Haczku A., Albelada S.M. and Krymskaya V.
- Journal Title
  
  Science Translational Medicine
  
  Volume: 4 Pages: 1-10
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Iron overload signature in chrysotile-induced mesothelioma.2012
- Author(s)
  Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S
- Journal Title
  
  Journal of Pathology
  
  Volume: 228巻3号 Pages: 366-377
- DOI
  10.1002/path.4075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590394, KAKENHI-PROJECT-23591363, KAKENHI-PROJECT-24390094, KAKENHI-PROJECT-24591377, KAKENHI-PROJECT-221S0001
[Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer2012
- Author(s)
  Liu Y, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- DOI
  10.1371/journal.pone.0043403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300338, KAKENHI-PROJECT-22500389, KAKENHI-PROJECT-22500997, KAKENHI-PROJECT-23590394, KAKENHI-PROJECT-23790456, KAKENHI-PROJECT-221S0001
[Journal Article] Detailed analysis of Japanese population substructure with focus on the Southwest Islands of Japan2012
- Author(s)
  Nishiyama, T., Kishino, H., Suzuki, S., Ando, R., Niimura, H., Uemura, H., Horita, M., Ohnaka, K., Kuriyama, N., Mastuo, K., Guang, Y., Wakai, K., Hamajima, N., and Tanaka, H
- Journal Title
  
  PloS one
  
  Volume: 7(4)
- DOI
  10.1371/journal.pone.0035000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300095, KAKENHI-PROJECT-23590806, KAKENHI-PROJECT-23790668, KAKENHI-PROJECT-221S0001
[Journal Article] Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation.2012
- Author(s)
  Kusakabe K, Ide N, Daigo Y, Itoh T, Higashino K, Okano Y, Tadano G, Tachibana Y, Sato Y, Inoue M, Wada T, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Tagashira S, Kido Y, Sakamoto S, et al.
- Journal Title
  
  ACS Med Chem Lett
  
  Volume: 3 Pages: 560-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Feasibility of large-scale screening using N-ERC/mesothelin levels in the blood for the early diagnosis of malignant mesothelioma2011
- Author(s)
  Imashimizu K., Shiomi K., Maeda M., Aoki N., Igarashi K., Suzuki F., Koizumi M., Suzuki K. and Hino O.
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 2 Pages: 409-411
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Autophagy-deficient mice develop multiple liver tumors2011
- Author(s)
  Takamura A., Komatsu M., Hara T., Sakamoto A., Kishi C., Waguri S., Eishi Y., Hino O., Tanaka K. and Mizushima N
- Journal Title
  
  Gene & Development
  
  Volume: 25 Pages: 795-800
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Deficiency of the Erc/mesothelingene ameliorates renal carcinogenesis in Tsc2 knockout mice2011
- Author(s)
  Zhang D., Kobayashi T., Kojima T., Kanenishi K., Hagiwara Y., Abe M., Okura H., Hamano Y., Sun G., Maeda M., Jishage K., Noda T. and Hino O.
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 720-727
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Identitication of Epstein-Barr Virus-Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer2011
- Author(s)
  Nishino R, et al
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Pages: 6272-6286
- DOI
  10.1158/1078-0432.ccr-11-0060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and Osteopontin2011
- Author(s)
  Shiomi K., Shiomi S., Ishinaga Y., Sakuraba M., Hagiwara Y., Miyashita K., Maeda M., Suzuki K., Takahashi K. and Hino O.
- Journal Title
  
  Anticancer Research
  
  Volume: 31 Pages: 1427-1430
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice2011
- Author(s)
  Zhang D, Kobayashi T, Hino O, et al
- Journal Title
  
  Cancer Sci.
  
  Volume: 102(4) Pages: 720-7
- DOI
  10.1111/j.1349-7006.2011.01846.x
- NAID
  10029291977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389, KAKENHI-PROJECT-23510244
[Journal Article] LRR4 and UPK3B are markers of primary mesothelial cells2011
- Author(s)
  Kanamori-Katayama M., Kaiho A., Ishizu Y., Okamura-Oho Y., Hino O., Abe M., Kishimoto T., Sekihara H., Nakamura Y., Suzuki H., Forrest A.R.R. and Hayashizaki Y.
- Journal Title
  
  PLoS One
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells2011
- Author(s)
  Inami Y., Waguri S., Sakamoto A., Kouno T., Nakada K., Hino O., Watanabe S., Andoh J., Iwadate M., Yamamoto M., Lee M-S., Tanaka K. and Komatsu M
- Journal Title
  
  J. Cell Biology
  
  Volume: 193 Pages: 275-284
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt2011
- Author(s)
  Nakamura H., Aoki H., Hino O. and Moriyama M
- Journal Title
  
  Hepatology Research
  
  Volume: 4 Pages: 455-462
- NAID
  10031144111
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo.2010
- Author(s)
  Inami K., Abe M., Takeda K., Hagiwara Y., Maeda M., Segawa T., Suyama M., Watanabe S., Hino O.
- Journal Title
  
  Cancer Sci. 101
  
  Pages: 969-974
- NAID
  10026591120
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo2010
- Author(s)
  Inami K., Abe M., Takeda K., Hagiwara Y., Maeda M., Segawa T., Suyama M., Watanabe S. and Hino O.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 969-974
- NAID
  10026591120
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization.2010
- Author(s)
  Inoue H., Uyama T., Suzuki T., Kazami M., Hino O., Kobayashi T., Kobayashi K., Tadokoro T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 391
  
  Pages: 1148-1153
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo2010
- Author(s)
  Inami K, Abe M, Hino O, et al
- Journal Title
  
  Cancer Sci
  
  Volume: 101(4) Pages: 969-74
- DOI
  10.1111/j.1349-7006.2009.01463.x
- NAID
  10026591120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubegene product2010
- Author(s)
  Wang L, Kobayashi T, Zhang D, Hino O, et al
- Journal Title
  
  FEBS Lett
  
  Volume: 584(1) Pages: 39-43
- DOI
  10.1016/j.febslet.2009.11.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] Knockdown of COPA, identified by loss-of-functiuon screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse mode2010
- Author(s)
  Sudo H., Tuji A., Sugyo A., Kohda M., Sogawa C., Yoshida C., Harada Y., Hino O. and Saga T.
- Journal Title
  
  Genomics
  
  Volume: 95 Pages: 210-216
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors2010
- Author(s)
  Obulhasim G., Fujii H., Matsumoto T., Yasen M., Abe M., Matsuoka S., Ohtsuji N. and Hino O.
- Journal Title
  
  Eur. J. Gynaec. Oncol.
  
  Volume: 31 Pages: 63-71
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter2010
- Author(s)
  Tan K, Hino O, Fujii H, et al
- Journal Title
  
  Hum Pathol
  
  Volume: 41(9) Pages: 1330-8
- DOI
  10.1016/j.humpath.2010.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] Serine 62 is phosphorylation site in folliculin, the Birt-Hogg-Dube gene product.2010
- Author(s)
  Wang L., Kobayashi T., Piao X., Shiono M., Takagi Y., Mineki R., Taka H., Zhang D., Abe M., Son G., Hagiwara Y., Okimoto K., Matsumoto I., Kouchi M., Hino O.
- Journal Title
  
  FEBS Letters 584
  
  Pages: 39-43
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Suppression of cell death by the secretory form of N-terminal ERC/mesothelin2010
- Author(s)
  Wang T., Kajino K., Abe M., Tan K., Maruo M., Sun G., Hagiwara Y., Maeda M. and Hino O.
- Journal Title
  
  Int. J. Molecular Med
  
  Volume: 26 Pages: 185-191
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization2010
- Author(s)
  Inoue H, Hino O, Kobayashi T, et al
- Journal Title
  
  iochem Biophys Res Commun
  
  Volume: 391(1) Pages: 1148-53
- DOI
  10.1016/j.bbrc.2009.12.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] Age depandence of rasiation-induced renal cell carcinomas in an Eker rat model2010
- Author(s)
  T. Kokubo, S. Kakinuma, M. Nishimura, Y. Shimada, et. Al
- Journal Title
  
  Cancer Sci
  
  Volume: 101(3) Pages: 616-23
- DOI
  10.1111/j.1349-7006.2009.01456.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21610029, KAKENHI-PROJECT-22500389
[Journal Article] Serum level of expressed in renal carcinoma (ERC)/mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)2010
- Author(s)
  Sakamoto Y., Nakae D., Hagiwara Y., Satoh K., Ohashi N., Fukamachi K., Tsuda H., Hirose A., Nishimura T., Hino O. and Ogata A.
- Journal Title
  
  The Jounal of Toxicological Sciences
  
  Volume: 35 Pages: 265-270
- NAID
  10026193564
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter2010
- Author(s)
  Tan K., Kajino K., Momose S., Masaoka A., Sasahara K., Shiomi K., Izumi H., Abe M., Ohtsuji N., Wang T., Hino O. and Fujii H.
- Journal Title
  
  Human Pathol
  
  Volume: 41 Pages: 1330-1338
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in mesothelioma mouse model2010
- Author(s)
  Yoshida C., Sogawa C., Tsuji A., Sudo H., Sugyo A., Uehara T., Hino O., Yoshii Y., Fujibayashi Y., Fukumura T., Koizumi M., Arano Y. and Saga T.
- Journal Title
  
  Nuclear Medicine Communications
  
  Volume: 31 Pages: 380-388
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia.2010
- Author(s)
  Ito S., Fujii H., Matsumoto T., Abe M., Ikeda K., Hino O.
- Journal Title
  
  Head Neck 32
  
  Pages: 96-103
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Age dependence of radiation-induced renal cell carcinomas in an Eker rat model.2010
- Author(s)
  Kokubo T., Kakinuma S., Kobayashi T., Watanabe F., Iritani R., Tateno K., Nishimura M., Nishikawa T., Hino O., Shimada Y.
- Journal Title
  
  Cancer Sci. 101
  
  Pages: 616-623
- NAID
  10026589138
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Suppression of cell death by the secretory form of N-terminal ERC/mesothelin2010
- Author(s)
  Wang T, Kajino K, Hino O, et al
- Journal Title
  
  Int J Mol Med
  
  Volume: 26(2) Pages: 185-91
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/20596597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] Establishment of novel monoclonal antibody to human ERC/mesothelin useful for study and diagnosis of ERC/mesothelin-expressing cancers.2009
- Author(s)
  Ishikawa K., Segawa T., Hagiwara Y., Maeda M., Abe M., Hino O.
- Journal Title
  
  Pathol. Int. 59
  
  Pages: 161-166
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Establishment and chracterization of renal carcinoma cell lines from a Bhd gene mutant (Nihon) rat.2009
- Author(s)
  Matsumoto I., Kouchi M., Okimoto K., Kijima K., Ueda T., Hirayama Y., Inoue T., Hino O.
- Journal Title
  
  Tumor Biology 30
  
  Pages: 249-256
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway.2009
- Author(s)
  Piao X., Kobayashi T., Wang L., Shiono M., Takagi Y., Sun G., Abe M., Hagiwara Y., Zhang D., Okimoto K., Kouchi M., Matsumoto I., Hino O.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 389
  
  Pages: 16-21
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] An animal model of precilinical diagnosis of pancreatic ductal carcinomas.2009
- Author(s)
  Fukamachi K., Tanaka H., Hagiwara Y., Ohara H., Joh T., Iigo M., Alexander D.B., Xu J., Long N., Takigahira M., Yonagihara K., Hino O., Saito I.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 390
  
  Pages: 636-641
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma.2008
- Author(s)
  Inami K., Kajino K., Abe M., Hgiwara Y., Maeda M., Suyama M., Watanabe S., Hino O.
- Journal Title
  
  Oncology Reports 20
  
  Pages: 1375-1380
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnipl-like (FnipL/Fnip2) protein.2008
- Author(s)
  Takagi Y., Kobayashi, T., Shiono M., Wang L., Piao X., Sun G., Zhang D., Abe M., Hagiwara Y., Takahashi K., Hino O.
- Journal Title
  
  Oncogene 27
  
  Pages: 5339-5347
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Racl activation.2008
- Author(s)
  Suzuki T., Das S.K., Inoue H., Kazami M., Hino O., Kobayashi T., Yeung R.S., Kobayashi K., Tadokoro T., Yamamoto Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun 368
  
  Pages: 132-137
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] ERC/mesothelin as a marker for chemotherapeutic response in patients with mesothelioma.2008
- Author(s)
  Tajima K., Hirama M., Shiomi K, Ishiwata T., Yoshioka M., Iwase A., Iwakami S., Yamazaki M., Toba M., Tobino K., Sugano K., Ichikawa M., Hagiwara Y., Takahashi K., Hino O.
- Journal Title
  
  Anticancer Research 28
  
  Pages: 3933-3936
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Establishment of a Novel Specific ELISA system for rat N- and C-ERC/Mesothelin. -Rat ERC/Mesothelin in the body fluids of mice bearing mesothelioma-.2008
- Author(s)
  Hagiwara Y., Hamada Y., Kuwahara M., Maeda M., Segawa T., Ishikawa K., Hino O.
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 666-670
- NAID
  10024004555
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma.2008
- Author(s)
  Shiomi K., Hagiwara Y., Sonoue K., Segawa T., Miyashita K., Maeda M., Izumi H., Masuda K., Hirabayashi M., Moroboshi T., Yoshiyama T., Ishida A., Natori Y., Inoue A., Kobayashi M., Sakao Y., Miyamoto H., Takahashi K., Hino O.
- Journal Title
  
  Clinical Cancer Res. 14
  
  Pages: 1431-1437
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Diagnostic tumor marker of asbestos-related messoth.2008
- Author(s)
  Hino O., Maeda, M.
- Journal Title
  
  Environmental Health and Preventive Medicine 13
  
  Pages: 71-74
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model.2008
- Author(s)
  Imamura O., Okada H., Takashima Y., Zhang D., Kobayashi T., Hino O.
- Journal Title
  
  Cancer Letters 268
  
  Pages: 278-285
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition.2008
- Author(s)
  Shiono M., Kobayashi T., Takahashi R., Sun G., Abe M., Zhang D., Wang L., Piao X., Takagi Y., Mineki R., Taka H., Tada N., Sonobe S., Momose S., Ueda M., Hino O.
- Journal Title
  
  Oncogene 27
  
  Pages: 6690-6697
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation2008
- Author(s)
  Suzuki T, Das SK, Inoue H, Kazami M, Hino O, Kobayashi T, Yeung RS, Kobayashi KI, Tadokoro T, Yamamoto Y.
- Journal Title
  
  Biochem Biophys Res Commun 368
  
  Pages: 132-137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Biphasic response of pancreatic β cell mass to ablation of TSC2 mice.2008
- Author(s)
  Shigeyama Y., Kobayashi T., Kido Y., Hashimoto N., Asahara S., Matsuda T., Takeda A., Inoue T., Shibutani Y., Koyanagi M., Uchida T., Inoue M., Hino O., Kasuga M., Noda T.
- Journal Title
  
  Mol. Cell. Biology 28
  
  Pages: 2971-2979
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Mesomark kit detects C-ERC/mesothelin, but not SMRP with C-terminus.2008
- Author(s)
  Segawa T., Hagiwara Y., Ishikawa K., Aoki N., Maeda M., Shiomi K., Hino O.
- Journal Title
  
  BBRC 369
  
  Pages: 915-918
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Establishment of the ELISA system to detect the amino terminal secretory form of rat Erc/ Mesothelin.2007
- Author(s)
  Nakaishi M., Kajino K., Ikesue M., Hagiwara Y., Kuwahara M., Mitani H., Horikoshi Y., Segawa T., Kon S., Maeda M., Baiyin T., Abe M., Yokoyama M., Hino O.
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 659-664
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo N-terminal hamartin-binding and C-termin.2007
- Author(s)
  Momose S., Kobayashi T., Tada N., Itoyama S., Hino O.
- Journal Title
  
  Biochem. Biophys. Res. Commun 356
  
  Pages: 693-698
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] GADD34 inhibits mammalian target of rapamycin signaling via tubero us sclerosis complex and controls cell survival under bioenergetic stress.2007
- Author(s)
  Watanabe R, Tambe Y, Inoue H, Isono T, Haneda M, Isobe K, Kobayashi T, Hino O, et al.
- Journal Title
  
  Int J Mol Med. 19・3
  
  Pages: 475-83
- Data Source
  KAKENHI-PROJECT-18500330
[Journal Article] A diagnostic biomarker of Asbestos-related mesothelioma-Example of translational research-2007
- Author(s)
  Hino, O., et. al.
- Journal Title
  
  Cancer Science 98
  
  Pages: 1147-1157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] GADD34 inhibits mammalian target of repamycin signaling via tuberous sclerosis complex and controls cell surbival under bioenergetic stress.2007
- Author(s)
  Watanabe R., Tambe Y., Inoue H., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T.
- Journal Title
  
  Int. J. Molecular Medicine 19
  
  Pages: 475-483
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Blood Tests for Asbestos-Related Mesothelioma.2007
- Author(s)
  Maeda M, Hino O
- Journal Title
  
  Oncology 71・1-2
  
  Pages: 26-31
- Data Source
  KAKENHI-PROJECT-18500330
[Journal Article] Birt-Hogg-Dube (BHD) gene mutations in human gastric cancer with high hrequency microsatellite instability.2007
- Author(s)
  Jiang W., Fujii H., Matsumoto T., Ohtsuji N., Tsurumaru M., Hino O.
- Journal Title
  
  Cancer Letter 248
  
  Pages: 103-111
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] The endoplasmic reticulum stress-inducible protein Niban regulates eIF2 α and S6K1/4E-BP1 phosphorylation.2007
- Author(s)
  Sun G.D., Kobayashi T., Abe M., Tada N., Adachi H., Shiota A., Totsuka Y., Hino O.
- Journal Title
  
  Biochem. Biophys. Res. Commun 360
  
  Pages: 181-187
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] A diagnostic biomarker of Asbestos-related mesothelioma-Example of translational research-.2007
- Author(s)
  Hino O., Shiomi K., Maeda M.
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 1147-1157
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin2007
- Author(s)
  Nakaishi, M., Kajino, K., Ikesue, M., Hagiwara, Y., Kuwahara, M., Mitani, H., Horikoshi-Sakuraba, Y., Segawa, T., Kon, S., Maeda, M., Wang, T., Abe, M., Yokoyama, M., Hino, O
- Journal Title
  
  Cancer Sci 98
  
  Pages: 659-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590748
[Journal Article] GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress2007
- Author(s)
  Watanabe R, Tambe Y, Inoue H, Isono T, Haneda M, Isobe K, Kobayashi T, Hino O, Okabe H, Chano T.
- Journal Title
  
  Int J Mol Med 19
  
  Pages: 475-483
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo2007
- Author(s)
  Momose S, Kobayashi T, Tada N, Itoyama S, Hino O.
- Journal Title
  
  Biochem Biophys Res Commun 356
  
  Pages: 693-698
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.2007
- Author(s)
  Minami K., Tambe Y., Watanabe R., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T., Inoue H.
- Journal Title
  
  J. Virology 81
  
  Pages: 11106-11115
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin2007
- Author(s)
  Nakaishi M, Kajino K, Ikesue M, Hagiwara Y, Kuwahara M, Mitani H, Horikoshi-Sakuraba Y, Segawa T, Kon S, Maeda M, Wang T, Abe M, Yokoyama M, Hino O.
- Journal Title
  
  Cancer Sci 98
  
  Pages: 659-664
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis2006
- Author(s)
  Matsumoto, F., Fujii, H., Abe, M., Kajino, K., Kobayashi, T., Matsumoto, T., Ikeda, K., Hino, O
- Journal Title
  
  Hum Pathol 37
  
  Pages: 1592-600
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590748
[Journal Article] 単一遺伝子病とゲノム遺伝性悪性腫瘍結節性硬化症.2006
- Author(s)
  樋野興夫, 小林敏之
- Journal Title
  
  ゲノム医学 6
  
  Pages: 89-94
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] [対がん戦略」がんの本質にせまる疾患モデル2006
- Author(s)
  樋野興夫
- Journal Title
  
  綜合臨床 55
  
  Pages: 419-424
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Disease models(in Japanese)2006
- Author(s)
  Hino O.
- Journal Title
  
  Sogo Rinsho 55
  
  Pages: 419-424
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway2006
- Author(s)
  Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 40242-40251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Blood tests for Asbestos-related mesothelioma.2006
- Author(s)
  Maeda M., Hino O.
- Journal Title
  
  Oncology 71
  
  Pages: 26-31
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Molecular tumor markers for asbestos-related mesothelioma : serum diagnostic markers2006
- Author(s)
  Maeda M, Hino O.
- Journal Title
  
  Pathol Int 56
  
  Pages: 649-654
- NAID
  10018400089
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Genetic and environmental factors in hereditary predisposition to tumors: a conceptual overview.2006
- Author(s)
  Hino O, et. al.
- Journal Title
  
  EXS 96
  
  Pages: 269-292
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Novel ELISA system for detection of "N-ERC/mesothelin" in the sera of mesothelioma patients.2006
- Author(s)
  Shiomi K., Miyamoto H., Segawa T., Hagiwara Y., Ota A., Maeda M., Takahashi K., Masuda K., Sakao Y., Hino O.
- Journal Title
  
  Cancer Sci 97
  
  Pages: 928-932
- NAID
  10018767738
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Tuberous sclerosis(in Japanese)2006
- Author(s)
  Hino O, Kobayashi T.
- Journal Title
  
  Genome Igaku 6
  
  Pages: 89-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Malignant perivascular epithelioid cell tumor of the colon : report of a case with molecular analysis2006
- Author(s)
  Yamamoto H, Oda Y, Yao T, Oiwa T, Kobayashi C, Tamiya S, Kawaguchi K, Hino O, Tsuneyoshi M.
- Journal Title
  
  Pathol Int 56
  
  Pages: 46-50
- NAID
  10017321109
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhdgene.2006
- Author(s)
  Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
- Journal Title
  
  Oncogene 25・20
  
  Pages: 2885-2889
- Data Source
  KAKENHI-PROJECT-17800004
[Journal Article] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube syndrome.2006
- Author(s)
  Kouchi M., Okimoto K., Matsumoto I., Tanaka K., Yasuba M., Hino O.
- Journal Title
  
  Virchow Archives 448
  
  Pages: 463-471
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Genetic and environmental factors in hereditary predisposition to tumors : a conceptual overview. Cancer. Cell Structures, Carcinogens and Genomic In stability.2006
- Author(s)
  Hino O., Kobayashi T., Okimoto K.
- Journal Title
  
  Edited by Leon P. Bignold. (in press)
- Data Source
  KAKENHI-PROJECT-17800004
[Journal Article] Novel ELISA system for detection on N-ERC/mesothelin in the sera of mesothelioma patients.2006
- Author(s)
  Shiomi K, Miyamoto H, Segawa T, Higiwara Y, Hino O, et al.
- Journal Title
  
  Cancer Sci. 97・9
  
  Pages: 928-932
- NAID
  10018767738
- Data Source
  KAKENHI-PROJECT-18500330
[Journal Article] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube(BHD) syndrome.2006
- Author(s)
  Kouchi, Mami, Okimoto, Kazuo, Matsumoto, Izumi, Tanaka, Kohji, Yasuba, Masashi, Hino, Okio
- Journal Title
  
  Virchow Archives 488・4
  
  Pages: 463-471
- Data Source
  KAKENHI-PROJECT-17800004
[Journal Article] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis2006
- Author(s)
  Matsumoto F, Fujii H, Abe M, Kajino K, Kobayashi T, Matsumoto T, Ikeda K, Hino O.
- Journal Title
  
  Hum Pathol 37
  
  Pages: 1592-1600
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Intraction of Fox01 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.2006
- Author(s)
  Cao Y., Kamioka Y., Yokoi N., Kobayashi T., Hino O., Onodera M., Mochizuki N., Nakae J.
- Journal Title
  
  J. Biological Chemistry 281
  
  Pages: 40242-40251
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation.2006
- Author(s)
  Chano T., Saji M., Inoue H., Minami K., Kobayashi T., Hino O., Okabe H.
- Journal Title
  
  Int. J. Molecular Medicine 18
  
  Pages: 425-432
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] A novel ELISA system for detection of a "N-ERC/Mesothelin" in the sera of mesothelioma patients.2006
- Author(s)
  Shiomi, K., Miyamoto, H., Segawa, T., Hagiwara, Y., Ota, A., Maeda., M., Takahashi, K., Masuda, K., Sakao, Y., Hino, O.
- Journal Title
  
  Cancer Sci. (in press)
- NAID
  10018767738
- Data Source
  KAKENHI-PROJECT-17800004
[Journal Article] Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation2006
- Author(s)
  Chano T, Saji M, Inoue H, Minami K, Kobayashi T, Hino O, Okabe H.
- Journal Title
  
  Int J Mol Med 18
  
  Pages: 425-432
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis.2006
- Author(s)
  Matsumoto F., Fujii H., Abe M., Kajino K., Kobayashi T., Matsumoto T., Ikeda K., Hino O.
- Journal Title
  
  Human Pathology 37
  
  Pages: 1592-1600
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Genetic and environmental factors in hereditary predisposition to tumors : a conceptual overview2006
- Author(s)
  Hino O, Kobayashi T, Okimoto K.
- Journal Title
  
  EXS 96
  
  Pages: 269-292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Gene Expression Profile of dbpA(DNA Binding Protein A)transgenic mice2006
- Author(s)
  Tobita, H., Kajino, K., Inami, I., Kano, S., Yasen, M., Imamura, O., Kinoshita, Y., Hino, O
- Journal Title
  
  Int J Oncol 29
  
  Pages: 673-679
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590748
[Journal Article] Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.2006
- Author(s)
  Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, et al.
- Journal Title
  
  J Biol Chem. 281・52
  
  Pages: 40242-51
- Data Source
  KAKENHI-PROJECT-18500330
[Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.2006
- Author(s)
  Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
- Journal Title
  
  Oncogene 25
  
  Pages: 2885-2889
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor.2005
- Author(s)
  Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O.et al.
- Journal Title
  
  Genes & Development 19
  
  Pages: 1779-1986
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Gene Expression Profile of dbpA (DNA Binding Protein A) transgenic mice.2005
- Author(s)
  Tobita H., Hino O., et al.
- Journal Title
  
  Int. J. Oncology (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] The up-regulation of Y box binding proteins (dbpA and YB-1) as prognostic markers of hepatocellular carcinoma.2005
- Author(s)
  Yasen M., Kajino K., Kano S., Tobita H., Yamamoto J., Uchiumi T., Kon S., Maeda M., Obulhasim G., Arii S., Hino O.
- Journal Title
  
  Clinical Cancer Research 11
  
  Pages: 7354-7361
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression2005
- Author(s)
  Ma L, Teruya-Feldstein J, Behrendt N, Chen Z, Noda T, Hino O, Cordon-Cardo C, Pandolfi PP.
- Journal Title
  
  Gene Dev 19
  
  Pages: 1779-1786
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor.2005
- Author(s)
  Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O., Cordon-Cardo C., Pandolli P.P.
- Journal Title
  
  Genes & Development 19
  
  Pages: 1779-1986
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Intentional delay of human hepatocarcinogenesis due to suppression of chronic hepatitis.2005
- Author(s)
  Hino O.
- Journal Title
  
  Intervirology 48
  
  Pages: 6-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.2005
- Author(s)
  Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P.S., Ishii N.
- Journal Title
  
  Cancer Research 65
  
  Pages: 203-209
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.2005
- Author(s)
  Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P.S., Ishii N.
- Journal Title
  
  Cancer Res 65
  
  Pages: 203-209
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Intentional delay of human hepatocarcinogenesis due to suppression of chronic hepatitis.2005
- Author(s)
  Hino O.
- Journal Title
  
  Intervirology 48
  
  Pages: 6-9
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] The up-regulation of Y box binding proteins (dbpA and YB-1) as prognostic markers of hepatocellular carcinoma.2005
- Author(s)
  Yasen M., Hino O.et al.
- Journal Title
  
  Clinical Cancer Research 11
  
  Pages: 7354-7361
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Model animals with a tuberous sclerosis gene(Tsc1/Tsc2) mutation2005
- Author(s)
  Kobayashi T, Hino O.
- Journal Title
  
  Molec Medi 42
  
  Pages: 1038-1043
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] 「肺LAMを探る分子生物学から臨床まで」 LAMのhistogenesisとM'MPH 遺伝子検索の現状をみる.2005
- Author(s)
  丸山博司, 樋野興夫
- Journal Title
  
  分子呼吸器病 9
  
  Pages: 420-425
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor.2005
- Author(s)
  Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O., Cordon-Cardo C., Pandolfi P.P.
- Journal Title
  
  Genes & Development 19
  
  Pages: 1779-1986
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] これからの疾患モデル動物家族性腫瘍結節性硬化症遺伝子(Tsc1/Tsc2)変異モデル動物2005
- Author(s)
  小林敏之, 樋野興夫
- Journal Title
  
  Molecular Medicine 42
  
  Pages: 1038-1043
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.2005
- Author(s)
  Togashi Y, Hino O., et al.
- Journal Title
  
  Oncogene (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Histogenesis of LAM and MMPH. Looking at the current status of gene examination(in Japanese)2005
- Author(s)
  Maruyama H, Hino O.
- Journal Title
  
  Molec Resp Dis 9
  
  Pages: 420-425
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Journal Article] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor.2005
- Author(s)
  Ma L., Hino O.et al.
- Journal Title
  
  Genes & Development 19
  
  Pages: 1779-1986
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Intentional delay of human hepatocarcinogenesis due to suppression on chronic hepatitis.2005
- Author(s)
  Hino O.
- Journal Title
  
  Intervirology 48
  
  Pages: 6-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Federal headship of human hepatocarcinogenesis.2005
- Author(s)
  Hino O.
- Journal Title
  
  In New Perspectives in Cancer Research and Therapy. Research Signpost (Edited Shigeki Kuriyama, Hitoshi Yoshiji)
  
  Pages: 125-130
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] The up-regulation of Y box binding proteins (dbpA and YB-1) as prognostic markers of hepatocellular carcinoma.2005
- Author(s)
  Yasen M., Kajino K., Kano S., Tobita H., Yamamoto J., Uchiumi T., Kon S., Hino O.et al.
- Journal Title
  
  Clinical Cancer Research 11
  
  Pages: 7354-7361
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.2005
- Author(s)
  Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P.S., Ishii N.
- Journal Title
  
  Cancer Research 65
  
  Pages: 203-209
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor.2005
- Author(s)
  Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O.et al.
- Journal Title
  
  Genes & Development 19
  
  Pages: 1779-1986
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Studies of familial tumors using models : genotype, phenotype, and dramatype in carcinogenesis.2004
- Author(s)
  Hino O.et al.
- Journal Title
  
  Int.J.Clin.Oncol. 9
  
  Pages: 257-261
- NAID
  10013569400
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model.2004
- Author(s)
  Hino O.et al.
- Journal Title
  
  Current Molecular Medicine 4
  
  Pages: 807-811
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model.2004
- Author(s)
  Hino O.et al.
- Journal Title
  
  Current Molecular Medicine 4
  
  Pages: 807-811
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] 癌発生観-過渡期の指導原理と新時代の形成力2004
- Author(s)
  樋野興夫
- Journal Title
  
  日本消化器病学会雑誌 101
  
  Pages: 855-859
- NAID
  10013548727
- Data Source
  KAKENHI-PROJECT-14310014
[Journal Article] The Niban gene is commonly expressed in renal tumors : A new candidate marker for renal carcinogenesis.2004
- Author(s)
  Adachi H., Majima S., Kon S., Kobayashi T., Kajino K., Mitani H., Shiina H., Igawa M., Hino O.
- Journal Title
  
  Oncogene 23
  
  Pages: 3495-3500
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] 家族性腫瘍とゲノム特集にあたって2004
- Author(s)
  樋野興夫
- Journal Title
  
  ゲノム医学 4
  
  Pages: 124-125
- Data Source
  KAKENHI-PROJECT-14310014
[Journal Article] A germline insertion in the Birt-Hogg-Dube' (BHD) gene gives rise to the Nihon Rat model of inherited renal cancer.2004
- Author(s)
  Okimoto K., Sakurai J., Kobayashi T., Mitani H., Hirayama Y., Nickerson M.L., Warren M.B., Zbar B., Schmidt L.S., Hino 0.
- Journal Title
  
  Proc Natl Acad Sci USA 101
  
  Pages: 2023-2027
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] 基礎の立場から-俯瞰的な「家族性腫瘍学」2004
- Author(s)
  樋野興夫
- Journal Title
  
  家族性腫瘍 5
  
  Pages: 2-4
- NAID
  130007539462
- Data Source
  KAKENHI-PROJECT-14310014
[Journal Article] Studies of familial tumors using models : genotype, phenotype, and dramatype in carcinogenesis.2004
- Author(s)
  Hino O.et al.
- Journal Title
  
  Int.J.Clin.Oncol. 9
  
  Pages: 257-261
- NAID
  10013569400
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Absence of allelic loss in cytomegalic neurons of cortical tuber in the Eker rat model of tuberous sclerosis.2004
- Author(s)
  Mizuguchi M., Mori M., Nozaki Y., Momoi M.Y., Itoh M., Takashima S., Hino 0.
- Journal Title
  
  Acta Neuropathol (Berl) 107
  
  Pages: 47-52
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Hereditary renal carcinogenesis fitting Knudson's two-hit model : genotype, environment, and phenotype.2003
- Author(s)
  Hino O
- Journal Title
  
  Genes Chromosomes Cancer 38
  
  Pages: 357-367
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Renal carcinogenesis : genotype, phenotype and dramatype.2003
- Author(s)
  Hino O.et al.
- Journal Title
  
  Cancer Sci 94
  
  Pages: 142-147
- NAID
  10016247074
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Renal carcinogenesis : genotype, phenotype and dramatype.2003
- Author(s)
  Hino 0., Kobayashi T., Momose S., Kikuchi Y., Adachi H., Okimoto K.
- Journal Title
  
  Cancer Sci 94
  
  Pages: 142-147
- NAID
  10016247074
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene.2003
- Author(s)
  Honda S., Kobayashi T., Kajino K., Urakami S., Igawa M., Hino 0.
- Journal Title
  
  Mo1 Carcinog 37
  
  Pages: 122-129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Hereditary renal carcinogenesis fitting Knudson's two-hit model : genotype, environment, and phenotype.2003
- Author(s)
  Hino 0.
- Journal Title
  
  Genes Chromosomes Cancer 38
  
  Pages: 357-367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling.2002
- Author(s)
  Gao, X., Zhang, Y., Arrazola, P., Hino, 0., Kobayashi, T., Yeung, R.S., Ru, B., Pan, D.
- Journal Title
  
  Nature Cell Biology 4
  
  Pages: 699-704
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Identification of the coding sequences responsible for Tsc 2-mediated tumor suppression using a transgenic rat system.2002
- Author(s)
  Momose, S., Kobayashi, T., Mitani, H., Hirabayashi, M., Ito, K., Ueda, M., Nabeshima, Y., Hino, 0.
- Journal Title
  
  Human Molecular Genetics, 11
  
  Pages: 2997-3006
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] A germ-line Tscl mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.2001
- Author(s)
  Kohayashi, T., Minowa, 0., Sugitani, Y., Takai, S., Mitani, H, Kobayashi, E, Noda, T., Hino, 0.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 98
  
  Pages: 8762-8767
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Multistep renalcarcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model-genotype, phenotype and environment.2001
- Author(s)
  Hino, 0., Majima, S., Kobayashi, T., Honda, S., Momose, S., Kikuchi, Y., Mitani, H.
- Journal Title
  
  Mutation Res 477
  
  Pages: 155-164
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] Multistep renalcarcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model-genotype, phenotype and environment.2001
- Author(s)
  Hino, O.et al.
- Journal Title
  
  Mutation Res. 477
  
  Pages: 155-164
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213139
[Journal Article] The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma
- Author(s)
  Mori T., Tajima K., Hirama M., Sato T., Kido K., Iwakami S., Sasaki S., Iwase A., Shiomi K., Maeda M., Hino O. and Takahashi K.
- Journal Title
  
  J. Thoracic Disease
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.
- Author(s)
  Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O.
- Journal Title
  
  Oncogene (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg一Dube (BHD) syndrome.
- Author(s)
  Kouchi, Mami, Okimoto, Kazuo, Matsumoto, Izumi, Tanaka, Kohji, Yasuba, Masashi, Hino, Okio
- Journal Title
  
  Virchow Archives (in press)
- Data Source
  KAKENHI-PROJECT-17800004
[Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.
- Author(s)
  Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma
- Author(s)
  Kawamata F., Homma S., Kamachi H., Einama T., Kato Y., Tsuda M., Tanaka S., Maeda M., Kajino K., Hino O., Takahashi N., Kamiyama T., Nishihara H., Taketomi A. and Todo S.
- Journal Title
  
  J. Gastroenterology
  
  Volume: (in press)
- NAID
  120005537455
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube syndrome.
- Author(s)
  Kouchi M., Okimoto K., Matsumoto I., Tanaka K., Yasuba M., Hino O.
- Journal Title
  
  Virchow Archives (in press)
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.
- Author(s)
  Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Genetic and environmental factors in hereditary predisposition to tumors : a conceptual overview. Cancer : Cell Structures, Carcinogens and Genomic Instability.
- Author(s)
  Hino 0., Kobayashi T., Okimoto K.
- Journal Title
  
  Edited by Leon P.Bignold. (in press)
- Data Source
  KAKENHI-PROJECT-17800004
[Journal Article] Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.
- Author(s)
  Kunogi M., Kurihara M., Shigihara-Ikegami T., Kobayashi T., Shindo N., Kumasaka T., Gunji Y., Kikkawa M., Iwakami S., Hino O., Takahashi K., Seyama K.
- Journal Title
  
  J. Med. Genetics (in press)
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in mesothelioma mouse model.
- Author(s)
  Yoshida C., Sogawa C., Tsuji A., Sudo H., Sugyo A., Uehara T., Hino O., Yoshii Y., Fujibayashi Y., Fukumura T., Koizumi M., Arano Y., Saga T.
- Journal Title
  
  Nuclear Medicine Communications (in press)
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Gene Expression Profile of dbpA (DNA Binding Protein A) transgenic mice.
- Author(s)
  Tobita H, Kajino K, Inami K, Kano S, Yasen M, Imamura O, Kinoshita Y, Hino O.
- Journal Title
  
  Int.J.Oncology (in press)
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer
- Author(s)
  Akatsuka S., Yamashita Y., Ohara H., Liu Y-T., Izumiya M., Abe K., Ochiai M., Jiang L., Nagai H., Okazaki Y., Murakami H., Sekido Y., Arai E., Kanai Y., Hino O., Takahashi T., Nakagama H. and Toyokuni S.
- Journal Title
  
  PloSONE
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22240093
[Journal Article] Gene Expression Profile of dbpA (DNA Binding Protein A) transgenic mice.
- Author(s)
  Tobita H, Kajino K, Inami K, Kano S, Yasen M, Imamura O, Kinoshita Y, Hino O.
- Journal Title
  
  Int.J.Oncology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390121
[Journal Article] Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway
- Author(s)
  Ohsawa M., Zhang D., Arai H., Uchiyama Y. and Hino O
- Journal Title
  
  Int. J. Oncology
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Gene Expression Profile of dbpA (DNA Binding Protein A) transgenic mice.
- Author(s)
  Tobita H, Kajino K, Inami K, Kano S, Yasen M, Imamura O, Kinoshita Y, Hino O.
- Journal Title
  
  Int.J.Oncology (in press)
- Data Source
  KAKENHI-PROJECT-17013076
[Journal Article] Ikaros is a critical target during simultaneous exposure to X-rays and N-ethyl-N-nitrosourea in mouse T-cell lymphomagenesis
- Author(s)
  Hirano S., Kakinuma S., Amasaki Y., Nishimura M., Imaoka T., Fujimono S., Hino O. and Shimada Y
- Journal Title
  
  International J. Cancer
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23659206
[Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhdgene.
- Author(s)
  Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-17800004
[Patent] 中皮種診断剤、中皮種診断キットおよび中皮種診断方法
- Inventor(s)
  樋野興夫、清藤勉
- Industrial Property Rights Holder
  株式会社免疫生物研究所
- Industrial Property Number
  2006-331409
- Data Source
  KAKENHI-PROJECT-17013076
[Presentation] Suffering of the female cancer patient informed of recurrence who has multiple problems for mother and child relations2019
- Author(s)
  Akemi Kurihara, Okio Hino
- Organizer
  Annual Meeting on Supportive Care In Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15933
[Presentation] 母親役割をもつがん患者の不安2018
- Author(s)
  栗原明美、樋野興夫
- Organizer
  第23回日本緩和医療学会
- Data Source
  KAKENHI-PROJECT-16K15933
[Presentation] Grief caused by the death of female cancer patients：daughters perspectives2018
- Author(s)
  栗原明美, 樋野興夫
- Organizer
  Global Academic Programs Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15933
[Presentation] A new approach to the tumor suppression by an anti-erbB-2 trifunctional antibody. Poster Session2016
- Author(s)
  Kato Y, Hirata H, Tsujisaki M, Matsune T, Adachi Y, Hinoda Y, Sasaki S, Imai K.
- Organizer
  10th Joint Conference of the American Association for Cancer Research（AACR）and the Japanese Cancer Association（JCA）
- Place of Presentation
  Maui, Hawaii, U.S.A.
- Year and Date
  2016-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ABCG2 gysfunction causes not only renal urate overload hyperuricemia but also renal-urate underexcretion hyperuricemia2015
- Author(s)
  Matsuo H, Nakayama A, Sakiyama M, Chiba T, Shimazu S, Nakashima H, Nakamura T, Takada Y, Takada T, Nakaoka H, Wakai K, Kawai S, Tin G, Nakagawa H, Ito T, Yamamoto K, Sakurai Y, Ichida K, Shimizu T, Shinomiya N
- Organizer
  第25回日本疫学会学術総会
- Place of Presentation
  ウインクあいち(愛知県・名古屋市)
- Year and Date
  2015-01-23
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Gene-trap mutagenesis is useful for analysis of long intergenic non-coding RNA genes.2015
- Author(s)
  Nakahara, M., Yoshinobu, K., Ito, H., Furuhata, R., Yamamura, K., Araki, M. and Araki, K.
- Organizer
  the 29th Annual Conference of the International Mammalian Genome Society
- Place of Presentation
  横浜市開港記念会館（神奈川県横浜市）
- Year and Date
  2015-11-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 新渡戸稲造とがん哲学外来～純度の高い専門性と社会的包容力～。2015
- Author(s)
  樋野興夫
- Organizer
  新渡戸稲造「武士道」出版115周年記念シンポジウム
- Place of Presentation
  札幌グランドホテル（北海道札幌市）
- Year and Date
  2015-04-19
- Invited
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] がん哲学外来～思いありのある、人生を位置づける　処方箋。2015
- Author(s)
  樋野興夫
- Organizer
  市立砺波総合病院　創立記念講演会
- Place of Presentation
  市立砺波総合病院（富山県砺波市）
- Year and Date
  2015-04-16
- Invited
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Genefic effect by dysfunctional variants of ABCG2 is tronger than environmental effects for hyperuricemia2015
- Author(s)
  Nakayama A, Matsuo H, Nakaoka H, Nakamura T, Nakashima H, Takada Y, Oikawa Y, Takada T, Sakiyama M, Shimizu S, Chiba T, Wakai K, Kawai S, Okada R, Tamura T, Shichijo Y, Akashi A, Sakurai Y, Ichida K, Shinomiya N
- Organizer
  第25回日本疫学会学術総会
- Place of Presentation
  ウインクあいち(愛知県・名古屋市)
- Year and Date
  2015-01-23
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] がん哲学外来の心得～温かい手・温かい心・温かい笑顔～。2015
- Author(s)
  樋野興夫
- Organizer
  第メディカルカフェ
- Place of Presentation
  近畿大学（大阪府東大阪市）
- Year and Date
  2015-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] A combination of the anti-fibroblast growth factor receptor 1 monoclonal antibody and interferon-a/b supresses human hepatic cancer cells in vitro and in vivo2014
- Author(s)
  Kato Y, Hiromi H, Tujisaki M, Matsune T, Sasaki S, Hinoda Y, Shinomura Y, Imai K
- Organizer
  41 Congress of the International Society of Oncology and Biomarkers
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] p53 family network and tumor suppression2014
- Author(s)
  Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
- Organizer
  The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
- Place of Presentation
  Zhangjiajie, China
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] ERC/mesothelinの最近の話題2013
- Author(s)
  樋野興夫
- Organizer
  第5回関東中皮腫症例検討会
- Place of Presentation
  東京
- Year and Date
  2013-01-22
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 中皮腫の早期診断と新規治療法の開発―大規模研究型検診―2013
- Author(s)
  樋野興夫
- Organizer
  平成24年度文部科学省がんプロフェッショナル養成基盤推進プラン採択事業　「先導的国際がん研究の動向」アスベスト暴露による中皮腫～環境発がんリスク予知と予防への新しい展開～
- Place of Presentation
  東京
- Year and Date
  2013-02-28
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Dysregulation of noncoding RNA genes and its clinical application.2013
- Author(s)
  Suzuki H, Yamamoto E, Shinomura Y and Imai K.
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference “Breakthroughs in Basic and Translational Cancer Research”
- Place of Presentation
  the Hyatt Regency Maui, Maui, HI, USA.
- Year and Date
  2013-02-21
- Invited
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Trans-Pacific variation in outcomes for men treated with primary androgen deprivation therapy for localized prostate cancer2013
- Author(s)
  Cooperberg M, Hinotsu S, Namiki M, Carroll P, Akaza H
- Organizer
  2013 AUA Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 次世代のがんプロに期待するもの2012
- Author(s)
  樋野興夫
- Organizer
  順天堂大学　医療維新をめざすICT研究者教育プラン　キックオフシンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-06-18
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 「遺伝性がんモデル」から「環境発がんモデル」への展開2012
- Author(s)
  樋野興夫
- Organizer
  発生工学・疾患モデル研究会終了記念講演会
- Place of Presentation
  東京
- Year and Date
  2012-10-23
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 中皮腫　発症前診断の取り組み2012
- Author(s)
  樋野興夫
- Organizer
  第3回「次世代の環境発がんを考える会」　―「中皮腫の早期診断と新規治療法の開発」―
- Place of Presentation
  東京
- Year and Date
  2012-08-01
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 肝発癌過程に関与するdbpAのストレス応答蛋白としての性質2007
- Author(s)
  稲見晃一, 梶野一徳, 飛田博史, 樋野興夫
- Organizer
  第15回日本消化器関連学会週間(JDDW2007)
- Place of Presentation
  神戸国際展示場
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-18590748
[Presentation] dbpA as the stress responsive protein in hepatocarcinogenesis2007
- Author(s)
  Inami, K., Kajino, K., Tobita, H., and Hino, O
- Organizer
  15 th DDW Japan
- Place of Presentation
  Kobe
- Year and Date
  2007-10-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590748
[Presentation] dbpA Tgマウスの肝発癌;形態的変化のない初期過程で発現の変化する遺伝子群2007
- Author(s)
  稲見晃一, 梶野一徳, 飛田博史, 樋野興夫
- Organizer
  第15回日本消化器関連学会週間
- Place of Presentation
  神戸国際展示場
- Year and Date
  2007-10-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590748
[Presentation] ヒト肝癌症例におけるdbpAの発現とプロモーターメチル化による発現制御2006
- Author(s)
  M Yasen, 梶野一徳, 有井滋樹, 樋野興夫
- Organizer
  第25回分子病理研究会
- Place of Presentation
  東京上野水月荘
- Year and Date
  2006-08-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590748
[Presentation] Malignant brain tumor in the cerebrum of the Eker rat model of tuberous sclerosis2005
- Author(s)
  Mizuguchi M, Itoh M, Takashima S, Yamanouchi H, Nakazato Y, Hino O.
- Organizer
  46th Annual Meeting of the Japanese Society of Neuropathology
- Place of Presentation
  Utsunomiya
- Year and Date
  2005-05-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222
[Presentation] Pathomechanism of hamartia and tumors in tuberous sclerosis2005
- Author(s)
  Mizuguchi M, Mori M, Nozaki Y, Itoh M, Takashima S, Hino O.
- Organizer
  45th Annual Meeting of the Japanese Society
- Place of Presentation
  Tokyo
- Year and Date
  2005-07-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500222

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HINO OKIO 樋野 興夫

HINO Okio 樋野 興夫

樋野 興夫 ヒノ オキオ

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Development of cancer education system in cooperation with school pharmacists in the regionOngoing

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Establishment of "cancer education and dialogue" based on "cancer philosophy"Principal Investigator

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母親役割をもつがんサバイバーが子供に病状説明をする際に生じる心理的葛藤と意志決定Ongoing

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Rehabilitation of cancer cellsPrincipal Investigator

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Rehabilitation of cancer cellsPrincipal Investigator

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Risk evaluation of environmental carcinogenesisPrincipal Investigator

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The study of multistep carcinogenesis using unique animal modelsPrincipal Investigator

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HINO OKIO 樋野興夫

HINO Okio 樋野興夫

樋野興夫ヒノオキオ