Shinomura Yasuhisa 篠村恭久

… Alternative Names

SHINOMURA Yasuhisa 篠村恭久

篠村泰久シノムラヤスヒサ

篠村恭久シノムラヤスヒサ

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Researcher Number	90162619
Other IDs
Affiliation (Current)	2022: 札幌医科大学, その他部局等, 名誉教授
Affiliation (based on the past Project Information) *help	2015 – 2017: 札幌医科大学, その他部局等, 名誉教授 2005 – 2015: Sapporo Medical University, School of Medicine, Professor, 医学部, 教授 1999 – 2004: Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 2001: 大阪大学, 医学系研究科, 助手 1997 – 1998: 大阪大学, 医学部, 助教授 1993 – 1996: 大阪大学, 医学部, 講師 1988: 大阪大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Cancer epidemiology and prevention / 内分泌・代謝学
Keywords	Principal Investigator c-kit / 胃癌 / メチル化 / GIST / 遺伝子変異 / ガストリン / 大腸癌 / マイクロRNA / 遺伝子診断 / 前癌病変 … More / エピゲノム / HOTAIR / エピジェネティクス / ゲノム / 平滑筋腫 / mutation / Helicobacter pylori / IL-1 / HB-EGF / CD9 / インターロイキン1β / ヒスタミン / ヒスチジン脱炭酸酵素 / ヘリコバクター・ピロリ / 萎縮性胃炎 / インターロイキン-1 / 肝細胞増殖因子 / サイトカイン / 過形成 / 酸分泌 / 転移 / 悪性黒色腫 / HGF / EGF / 消化管間質腫瘍 / マイクロ RNA / 標的遺伝子 / Gene expression / hypermethylation / hypomethylation / LINE-1 / H.pylori / H. pylori / 上部消化管学 / 消化管癌 / miR-196a / 癌間質 / 癌幹細胞 / non-coding RNA / 次世代シークエンサー / ncRNA / ChIP-seq / 消化管間葉系腫瘍 / 突然変異 / 消化管間葉腫瘍 / stromal tumor / 消化管運動 / カハール介在細胞 / ペースメーカー / 消化管運動異常症 / カハール / gastrointestinal motility / interstitial cells of Cajal / pacemaker / 消化管腫瘍 / 平滑筋肉腫 / アポトーシス / gastrointestinal stromal tumor / leimyoma / leiomyosarcoma / apoptosis / 胃炎 / NF-κB / p38-MAPK / PKC / gastric cancer / gastrin / gastritis / 消化器癌 / 発癌リスク予測 / 遺伝子不安定性 / gastrointestinal cancer / methylation / epigenetics / genetic diagnosis / prediction of cancer risk / 食道癌 / Fusobacterium / ESD … More Except Principal Investigator 胃癌 / HB-EGF / hepatocyte growth factor / amphiregulin / 遺伝子発現 / トランスジェニックマウス / 大腸癌 / 消化器癌 / ヘリコバクター・ピロリ / 胃炎 / 胃粘膜 / DNAメチル化 / 分子標的 / アポトーシス / STAT3 / ras / bcl-xL / bak / IRF-1 / PPARγ / cyclin D1 / AP-1 / Ets / 増殖 / 分化 / IL-10 / CD40 / NF-kappaB / ガストリン / 胃上皮細胞 / IKK / protein kinase C / NIK / TRAF6 / p38MAPK / Helicobacter Pylori / bFGF / dominant negative / tyrosine kinase inhibitor / Akt / 胃粘膜上皮細胞 / 培養 / 細胞増殖因子 / サイトカイン / ヘリバクプター / 細胞毒素 / 消化性潰瘍 / インターロイキン-1β / 胃十二指腸潰瘍 / インターロイキン-1 / mRNA / 皺襞腫大 / 組織修復 / ヘリコバクター / 変異原性物質 / Amesテスト / 胃酸 / interleukin-1β / 粘膜修復 / エピジェネティクス / ヒストン修飾 / 個別化医療 / 遺伝子診断 / 分子標的治療 / メチル化 / 腫瘍マーカー / 肝臓学 / 肝癌 / 抗体治療 / 分子改変 / 癌 / 機能性RNA / 日米欧比較 / 分子疫学 / SNP / マイクロRNA / EGF受容体 / EGF関連ペプチド / ドミナント・ネガティブ / 修復 / 癌化 / EGF receptor / EGF-related peptides / apoptosis / dominant-negative / ミスセンス変異 / Star3 / IRF-2 / アポト-シス / astat3 / Gastric cancer / Colorectal cancer / Apoptosis / Missence mutation / Stat3 / 消化管上皮 / growth / differentiation / クローン病 / マクロファージ / マウス / エンドトキシン / TNFα / IL-12 / Conh's disease / macrophage / mice / lipopolysaccharide / H.pylori / H-pylori / gastrin / gastric epithelial cells / MKK6 / 分化・増殖 / Gastric Mucosal Cell / MMK6 / Differentiation / Proliferation / Gastrin / HGF / GFP / pro HB-EGF / 細胞移植 / 肝再生療法 / 骨髄細胞 / 肝再生 / 骨髄間葉系幹細胞 / 細胞移植療法 / 再生医療 / hepatocyte / bone marrow cells / trans-differentiation / cell transplantation / regenerative medicine / インスリン様増殖因子 / 細胞外基質分解酵 / マイクロサテライト不安定性 / IGF1 receptor / 細胞外基質分解酵素 / ERK / IGF-I receptor / Akt-1 / bystander効果 / insulin-like growth factor / extracellular matrix degrading enzyme / gastrointestinal cancer / microsatellite instability / IGF- 1 receptor / 尿酸 / ヒポキサンチン / グリコ-ゲン病 / 高尿酸血症 / ミオパチ- / 運動 / オキシプリン / 筋原性高尿酸血症 / プリン体代謝 / ミオパチー / グリコーゲン病 / ミトコンドリア脳筋症 / 甲状腺機能低下症 / 電解質異常 / 運動負荷試験 / Unicacid / Hypoxanthine / Glycogenosis / Hyperunicemia / Myopathy / Exercise / 若手支援 / 国際研究者交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 次世代分子解析技術 / アカデミア創薬 / ゲノム・エピゲノム解析支援 / 個別化がん予防 / 国際交流 / ATL発症予防 / 分子疫学コーホート研究 / がん化学予防 / ATL発がん機序 / ATL発症リスク / がん分子標的薬剤 Less

Genome and epigenome analysis of early esophageal cancer and the development of molecular diagnosis using endoscopic washPrincipal Investigator
- Principal Investigator
  
  Shinomura Yasuhisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Analysis of long non-coding RNAs that predict biological malignancy in GISTPrincipal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Molecular epidemiological elucidation of Japanese, American, and European gastric and colorectal carcinogenesis by integrated analysis of functional RNA and clinical application and cancer prevention
- Principal Investigator
  
  YAMAMOTO Hiroyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cancer epidemiology and prevention
- Research Institution
  St. Marianna University School of Medicine
  Sapporo Medical University
Analysis of the abnormalities of microRNA and epigenome and the clinical application in gastroenterological cancersPrincipal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Epigenomic analysis of gastrointestinal cancer stromaPrincipal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Establishment of a treatment for advanced hepatocellular carcinoma using a tri-functional specific antibody
- Principal Investigator
  
  SASAKI Shigeru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterationsPrincipal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
消化管間質腫瘍におけるマイクロRNA発現異常の解明Principal Investigator
- Principal Investigator
  
  篠村恭久
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Mechanism of development and progression of gastrointestinal cancer by analysis of insulirrlike growth factor system and extracelluar matrix degrading enzymes
- Principal Investigator
  
  YAMAMOTO Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Development of diagnostic methods of gastrointestinal cancer using integrated analysis of nuclear moleculesPrincipal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy
- Principal Investigator
  
  IMAI Kohzoh
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Development of therapeutic transplantation of human bone marrow mesenchymal cells into injured liver.
- Principal Investigator
  
  KISO Shinichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  OSAKA UNIVERSITY
Analysis of proliferation and differentiation in the gastric epithelial cells derived from p38MAPK transgene mouse.
- Principal Investigator
  
  TSUTSUI Shusaku
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
新規癌転移関連分子Mlzeの機能解析-消化器癌の転移における役割-Principal Investigator
- Principal Investigator
  
  篠村恭久
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Interaction of proinflammatory cytokines and growth factors in gastric carcinogenesisPrincipal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of a new therapy of Chohn's disease by the regulation of Macrophage/Monocyte function
- Principal Investigator
  
  KIYOHARA Tatsuya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Role of NF-kappaB in the growth, differentiation and apoptosis of gastric epithelial cells
- Principal Investigator
  
  MIYAZAKI Yoshiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Effect of gain-of-function mutation of c-kit on apoptosis in gastrointestinal mesenchymal cellsPrincipal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of novel therapeutics targeting the function of intestinal cells of Cajal in gastrointestinal motility disorderPrincipal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Role of PPARγ in the growth, differentiation and apoptosis of gastrointestinal epithelial cells.
- Principal Investigator
  
  MIYAZAKI Yoshiji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Research on the abnormal expressions of bcl-xL and bak in gastrointestinal cancers
- Principal Investigator
  
  KANAYAMA Shuji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Role of gain-of-function mutations of c-kit gene on tumor development in gastrointestinal stromal tumor.Principal Investigator
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Role of EGF receptor in the growth, differentiation and apoptosis resistance of gastrointestinal epithelial cells.
- Principal Investigator
  
  MIYAZAKI Yoshiji, 東本好文
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
ヘリコバクター胃炎における胃癌発生メカニズムの解明と除菌対象群の設定
- Principal Investigator
  
  金山周次
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
トランスジェニックマウスを用いたHB-EGFの胃機能調節と発癌における役割の研究
- Principal Investigator
  
  東本好文
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
慢性萎縮性胃炎における胃粘膜細胞の増殖・分化に関わる炎症性サイトカインの役割Principal Investigator
- Principal Investigator
  
  篠村恭久
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
胃癌、胃十二指腸潰瘍の発症におけるヘリコバクター病原性因子の役割
- Principal Investigator
  
  金山周次
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
トランスジェニックマウスを用いた肝細胞増殖因子(HGF)の胃における役割の検討
- Principal Investigator
  
  東本好文
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
消化性潰瘍,胃癌の発症における宿主側免疫遺伝子とヘリコバクター細胞毒素の役割
- Principal Investigator
  
  金山周次
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
サイトカインの胃粘膜機能制御に及ぼす影響Principal Investigator
- Principal Investigator
  
  篠村恭久
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
ヒト胃粘膜上皮細胞培養系の開発
- Principal Investigator
  
  金山周次
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
The mechanism of a novel type of hyperuricemia, "myogenic hyperuricemia"
- Principal Investigator
  
  KONO Norio
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University Medical School

[Book] 大腸腺腫と大腸鋸歯状病変における遺伝子異常と生活習慣の関連2014
- Author(s)
  五十嵐央祥、能正勝彦、伊藤美樹、篠村恭久
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-221S0001
[Book] Inflammation-related aberrant patterns of DNA methylation : detection and role in epigenetic deregulation of cancer cell transcriptome. Inflammation and Cancer. Methods and Protocols : Volume 2 : Molecular Analysis and Pathways. Methods in Molecular Biology Edited by Serguei V. New York, USA. 5122009
- Author(s)
  Suzuki H, Toyota M, Kondo Y, Shinomura Y.
- Publisher
  Kozlov. Humana Press
- Data Source
  KAKENHI-PROJECT-20390210
[Book] 消化管と遺伝子異常. 消化管病理標本の読み方改訂2版2008
- Author(s)
  豊田実、今井浩三、篠村恭久, 中村眞一. (編集)
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-17109008
[Book] The role and clinical implication of DNA methylation in gastrointestinal cancer. Recent Advances in Gastrointestinal Carcinogenesis.2006
- Author(s)
  Toyota M, Suzuki H, Maruyama R, Tarasawa I, Yamamoto E, Tokino T, Imai K, Shinomura Y
- Publisher
  Edited by Bamba H and Ota S, Transworld Research Network, Kerala, India
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway.2016
- Author(s)
  Kurihara H, Maruyama R, Ishiguro K, Kanno S, Yamamoto I, Ishigami K, Mitsuhashi K, Igarashi H, Ito M, Tanuma T, Sukawa Y, Okita K, Hasegawa T, Imai K, Yamamoto H, Shinomura Y, Nosho K.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 11 Pages: 12704-120717
- DOI
  10.18632/oncotarget.7260
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-16K07145, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer.2016
- Author(s)
  Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 22 Pages: 557-566
- DOI
  10.3748/wjg.v22.i2.557
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer.2015
- Author(s)
  Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 14 Pages: 2640-2648
- DOI
  10.1245/s10434-014-4264-7
- Description
  Epub ahead of print
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670371, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-26293290
[Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: results from the SMART database.2015
- Author(s)
  Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
- Journal Title
  
  Modern Rheumatology
  
  Volume: 27 Pages: 199-204
- DOI
  10.3109/14397595.2014.950036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861575, KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
[Journal Article] Contextual niche signals towards colorectal tumor progression by mesenchymal stem cell in the mouse xenograft model2015
- Author(s)
  Nakagaki S, Arimura Y, Nagaishi K, Isshiki H, Nasuno M, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y
- Journal Title
  
  J Gastroenterol
- Description
  【掲載確定】 Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy.2015
- Author(s)
  Mitsuhashi K, Yamamoto I, Kurihara H, Kanno S, Ito M, Igarashi H, Ishigami K, Sukawa Y, Tachibana M, Takahashi H, Tokino T, Maruyama R, Suzuki H, Imai K, Shinomura Y, Yamamoto H, Nosho K
- Journal Title
  
  Oncotarget
  
  Volume: 6 Pages: 22114-22125
- DOI
  10.18632/oncotarget.4294
- NAID
  130005161488
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
[Journal Article] Low-Frequency IL23R Coding Variant Associated with Crohn's Disease Susceptibility in Japanese Subjects Identified by Personal Genomics Analysis2015
- Author(s)
  Onodera K, Arimura Y, Isshiki H, Kawakami K, Nagaishi K, Yamashita K, Yamamoto E, Niinuma T, Naishiro Y, Suzuki H, Imai K, Shinomura Y
- Journal Title
  
  Plos One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0137801
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08972, KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-26460975, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25460954, KAKENHI-PROJECT-25460955, KAKENHI-PROJECT-26640101
[Journal Article] 抗体治療特集「DDSがもたらした新しい臨床の風景」2015
- Author(s)
  佐々木茂, 篠村恭久, 今井浩三
- Journal Title
  
  Drug Delivery System
  
  Volume: 30 Issue: 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients.2015
- Author(s)
  Nosho K, Igarashi H, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yoshii S, Mikami M, Takahashi H, Kusumi T, Hosokawa M, Sukawa Y, Adachi Y, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
- Journal Title
  
  Digestion
  
  Volume: 91(1) Issue: 1 Pages: 57-63
- DOI
  10.1159/000368820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25293289
[Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.2015
- Author(s)
  Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
- Journal Title
  
  Oncotarget.
  
  Volume: 6 Pages: 29975-29990
- DOI
  10.18632/oncotarget.5034
- NAID
  130005161526
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K18431, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-26640101
[Journal Article] Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis2015
- Author(s)
  Mitsuhashi K, Nosho K, Sukawa Y, Matsunaga Y, Ito M, Kurihara H, Kanno S, Igarashi H, Naito T, Adachi Y, Tachibana M, Tanuma T, Maguchi H, Shinohara T, Hasegawa T, Imamura M, Kimura Y, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y
- Journal Title
  
  Oncotarget
- Description
  【掲載確定】 in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway.2015
- Author(s)
  Ito M, Kanno S, Nosho K, Sukawa Y, Mitsuhashi K, Kurihara H, Igarashi H, Takahashi T, Tachibana M, Takahashi H, Yoshii S, Takenouchi T, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 137 Pages: 1258-1268
- DOI
  10.1002/ijc.29488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14397, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-26640101
[Journal Article] Role of interleukin-32 in the mechanism of chronic inflammation in IgG4-related disease and as a predictive biomarker for drug-free remission.2015
- Author(s)
  Shimizu Y, Yamamoto M, Yajima H, Suzuki C, Naishiro Y, Takahashi H, Imai K, Shinomura Y.
- Journal Title
  
  Modern Rheumatology
  
  Volume: 26(3) Pages: 391-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] HER2 Expression and PI3K-Akt Pathway Alterations in Gastric Cancer2014
- Author(s)
  Sukawa Y, Yamamoto H, Nosho K, Ito M, Igarashi H, Naito T, Mitsuhashi K, Matsunaga Y, Takahashi T, Mikami M, Adachi Y, Suzuki H, Shinomura Y.
- Journal Title
  
  Digestion
  
  Volume: 89 Pages: 12-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma.2014
- Author(s)
  Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y
- Journal Title
  
  Tumor Biol
  
  Volume: 35 Issue: 2 Pages: 973-85
- DOI
  10.1007/s13277-013-1131-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-24650632, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma2014
- Author(s)
  Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y.
- Journal Title
  
  Tumour Biol.
  
  Volume: 35 Pages: 973-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.2014
- Author(s)
  Suzuki R, Nosho K (他14名), Yamamoto H, Shinomura Y
- Journal Title
  
  J Gastroenterol.
  
  Volume: (Epub ahead of print) Pages: 1135-1144
- DOI
  10.1007/s00535-013-0861-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23791283, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-25670371, KAKENHI-PROJECT-25830103, KAKENHI-PROJECT-25860547, KAKENHI-PROJECT-25860548
[Journal Article] Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway2014
- Author(s)
  Nosho K, Igarashi H, Nojima M, Ito M, Maruyama R, Yoshii S, Naito T, Sukawa Y, Mikami M, Sumioka W, Yamamoto E, Kurokawa S, Adachi Y, Takahashi H, Okuda H, Kusumi T, Hosokawa M, Fujita M, Hasegawa T, Okita K, Hirata K, Suzuki H, Yamamoto H, Shinomura Y.
- Journal Title
  
  Carcinogenesis
  
  Volume: 35 Pages: 776-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2014
- Author(s)
  Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y. et al.
- Journal Title
  
  J Gastroenterol
  
  Volume: 49 Pages: 1135-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa2014
- Author(s)
  Yamamoto H, Watanabe Y, Maehata T, Morita R, Yoshida Y, Oikawa R, Ishigooka S, Ozawa SI, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Shinomura Y, Itoh F
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20 Pages: 3927-3937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366
[Journal Article] Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer2014
- Author(s)
  Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y
- Journal Title
  
  Annals of Surgical Oncology
- Description
  Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] 大規模コホートを用いた大腸癌のノンコーディングRNA発現異常と生活習慣の分子疫学的解析2014
- Author(s)
  能正勝彦, 五十嵐央祥, 伊藤美樹, 三橋慧, 栗原弘義, 菅野伸一, 内藤崇史, 須河安恭敬, 松永康孝, 足立靖, 野島正寛, 今井浩三, 丸山玲緒, 鈴木拓, 山本博幸, 篠村恭久
- Journal Title
  
  日本癌病態治療研究会誌
  
  Volume: 20 Issue: 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway2014
- Author(s)
  Nosho K (他18名), Igarashi H, Ito M, Nojima M, Yamamoto H, Shinomura Y
- Journal Title
  
  Carcinogenesis
  
  Volume: 35 Pages: 776-783
- DOI
  10.1093/carcin/bgt374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-25670371
[Journal Article] Mesenchymal stem cells cancel azoxymethane-induced tumor initiation.2014
- Author(s)
  Nasuno M, Arimura Y, Nagaishi K, Isshiki H, Onodera K, Nakagaki S, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y
- Journal Title
  
  STEM CELLS
  
  Volume: 32 Issue: 4 Pages: 913-25
- DOI
  10.1002/stem.1594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-24650632, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-25460954, KAKENHI-PROJECT-25460955, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.2014
- Author(s)
  Ito M, Mitsuhashi K, Igarashi H, Nosho K, Yamamoto H
- Journal Title
  
  International Journal of Cancer
  
  Volume: (Epub ahead of print) Issue: 11 Pages: 2507-15
- DOI
  10.1002/ijc.28920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] HER2 expression and PI3K-Akt pathway alterations in gastric cancer2014
- Author(s)
  Sukawa Y, Yamamoto H (他9名), Nosho K, Shinomura Y
- Journal Title
  
  Digestion
  
  Volume: 89 Pages: 12-17
- DOI
  10.1159/000356201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2014
- Author(s)
  Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y
- Journal Title
  
  J Gastroenterol
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366
[Journal Article] Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer2014
- Author(s)
  Harada T, Yamamoto E, Yamano HO, Nojima M, Maruyama R, Kumegawa K, Ashida M, Yoshikawa K, Kimura T, Harada E, Takagi R, Tanaka Y, Aoki H, Nishizono M, Nakaoka M, Tuyada A, Niinuma T, Kai M, Shimoda K, Shinomura Y, Sugai T, Imai K, Suzuki H.
- Journal Title
  
  Cancer Prevention Research (Philadelphia, Pa.)
  
  Volume: 7(10) Issue: 10 Pages: 1002-10
- DOI
  10.1158/1940-6207.capr-14-0162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions2014
- Author(s)
  Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20(29) Issue: 29 Pages: 10050-61
- DOI
  10.3748/wjg.v20.i29.10050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa.2014
- Author(s)
  Yamamoto H (他14名), Nosho K, Shinomura Y
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 20 Pages: 3927-3937
- DOI
  10.3748/wjg.v20.i14.3927
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590928, KAKENHI-PROJECT-25460937, KAKENHI-PROJECT-25670371
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.2013
- Author(s)
  Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: [Epub ahead of print]
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2013
- Author(s)
  Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Model of translational cancer research in multiple myeloma2012
- Author(s)
  Yasui H, Ishida T, Maruyama R, Nojima M, Ikeda H, Suzuki H, Hayashi T, Shinomura Y, Imai K
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 1907-1912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] IGF-I receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers2012
- Author(s)
  Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 252-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer.2012
- Author(s)
  Sukawa Y, Yamamoto H (他11名), Nosho K, Shinomura Y
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 18 Pages: 6577-6586
- DOI
  10.3748/wjg.v18.i45.6577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23790800
[Journal Article] Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer2012
- Author(s)
  Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y
- Journal Title
  
  World J Gastroenterol
  
  Volume: 18 Pages: 2745-2755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Aberrant DNA methylation associatedwith aggressiveness of gastrointestinal stromal tumour2012
- Author(s)
  Okamoto Y, Sawaki A, Ito S, Nishida T, Takahashi T, Toyota M, Suzuki H, Shinomura Y, Takeuchi I, Shinjo K, An B, Ito H, Yamao K, Fujii M, Murakami H, Osada H, Kataoka H, Joh T, Sekido Y, Kondo Y
- Journal Title
  
  Gut
  
  Volume: 61 Pages: 392-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] The effective molecular targeted therapies for gastroenterological tumors2012
- Author(s)
  Nosho K, Shinomura Y.
- Journal Title
  
  Medical Science Digest., Japan
  
  Volume: 38 Pages: 154-157
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer.2012
- Author(s)
  Takamaru H, Yamamoto E, Suzuki H.
- Journal Title
  
  Cancer Prev Ther (Phila)
  
  Volume: 5(10) Pages: 1203-12
- DOI
  10.1158/1940-6207.capr-12-0056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
[Journal Article] IGF-I receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers2012
- Author(s)
  Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 103 Pages: 252-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer.2012
- Author(s)
  Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M,Mikami M, Matsuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y
- Journal Title
  
  World J Gastroenterol
  
  Volume: 18 Pages: 6577-6586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype2012
- Author(s)
  Yamamoto E, Suzuki H, Yamano HO, Maruyama R, Nojima M, Kamimae S, Sawada T, Ashida M, Yoshikawa K, Kimura T, Takagi R, Harada T, Suzuki R, Sato A, Kai M, Sasaki Y, Tokino T, Sugai T, Imai K, Shinomura Y, Toyota M
- Journal Title
  
  Am J Pathol
  
  Volume: 181 Pages: 1847-1861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012
- Author(s)
  Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y
- Journal Title
  
  Cancer Res
  
  Volume: 72 Pages: 1126-1136
- NAID
  10031131121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma2012
- Author(s)
  Kimura T, Yamamoto E, Yamano HO, Suzuki H, Kamimae S, Nojima M, SawadaT, Ashida M, Yoshikawa K, Takagi R, Kato R, Harada T, Suzuki R, Maruyama R, Kai M, Imai K, Shinomura Y, Sugai T, Toyota M
- Journal Title
  
  Am J Gastroenterol
  
  Volume: 107 Pages: 460-469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.2012
- Author(s)
  Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y.
- Journal Title
  
  World J Gastroenterol.
  
  Volume: 18 Pages: 2745-2755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer2012
- Author(s)
  Takamaru H, Yamamoto E, Suzuki H, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Suzuki R, Yamamoto H, Kai M, Tokino T, Sugai T, Imai K, Toyota M, Shinomura Y.
- Journal Title
  
  Cancer Prev Res
  
  Volume: 5 Pages: 1203-1212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.2012
- Author(s)
  Takeshi Niinuma
- Journal Title
  
  Cancer Research
  
  Volume: 72 Pages: 1126-1136
- DOI
  10.1158/0008-5472.can-11-1803
- NAID
  10031131121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
[Journal Article] Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer.2012
- Author(s)
  Maruyama R, Suzuki H, Yamamoto E, Imai K, Shinomura Y.
- Journal Title
  
  Tumour Biol.
  
  Volume: 33 Pages: 275-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Model of translational cancer research in multiple myeloma.2012
- Author(s)
  Yasui H, Ishida T, Maruyama R, Nojima M, Ikeda H, Suzuki H, Hayashi T, Shinomura Y, Imai K.
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 1207-1212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012
- Author(s)
  Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y.
- Journal Title
  
  Cancer Res.
  
  Volume: 72 Pages: 1126-1136
- NAID
  10031131121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Alterations in the HER2-PI3K-Akt pathway in gastric cancer2012
- Author(s)
  Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 18 Pages: 6577-6586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.2012
- Author(s)
  Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 18 Pages: 2745-2755
- DOI
  10.3748/wjg.v18.i22.2745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200
[Journal Article] Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma2012
- Author(s)
  Shitani M, Sasaki S, Akutsu N, Takagi H, Suzuki H, Nojima M, Yamamoto H, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y
- Journal Title
  
  Tumour Biol
  
  Volume: 33 Pages: 1307-1317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer2012
- Author(s)
  Maruyama R, Suzuki H, Yamamoto E, Imai K, Shinomura Y
- Journal Title
  
  Tumour Biol
  
  Volume: 33 Pages: 277-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors2011
- Author(s)
  Kamimae S, Yamamoto E, Yamano HO, Nojima M, Suzuki H, Ashida M, Hatahira T, Sato A, Kimura T, Yoshikawa K, Harada T, Hayashi S, Takamaru H, Maruyama R, Kai M, Nishiwaki M, Sugai T, Sasaki Y, Tokino T, Shinomura Y, Imai K, Toyota M
- Journal Title
  
  Cancer Prev Res
  
  Volume: 4 Pages: 674-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis2011
- Author(s)
  Hizaki K, Yamamoto H, Taniguchi H, Adachi Y, Nakazawa M, Tanuma T, Kato N, Sukawa Y, Sanchez JV, Suzuki H, Sasaki S, Imai K, Shinomura Y
- Journal Title
  
  Mod Pathol
  
  Volume: 24 Pages: 876-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Interferon-α/βand anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo2011
- Author(s)
  Sasaki S, Ishida T, Toyota M, Ota A, Suzuki H, Takaoka A, Yasui H, Yamamoto H, Takagi H, Maeda M, Seito T, Tsujisaki M, Shinomura Y, Imai K
- Journal Title
  
  PLoS One
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590853
[Journal Article] Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis.2011
- Author(s)
  Hizaki K, Yamamoto H, Taniguchi H, Adachi Y, Nakazawa M, Tanuma T, Kato N, Sukawa Y, Sanchez JV, Suzuki H, Sasaki S, Imai K, Shinomura Y.
- Journal Title
  
  Mod Pathol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] The efficacy of IGF-I receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation status2011
- Author(s)
  Ii M, Li H, Adachi Y, Yamamoto H, Ohashi H, Taniguchi H, Arimura Y, Carbone DP, Imai K, Shinomura Y
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Pages: 5048-5059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer2011
- Author(s)
  Ii M, Yamamoto H, Taniguchi H, Adachi Y, Nakazawa M, Ohashi H, Tanuma T, Sukawa Y, Suzuki H, Sasaki S, Imai K, Shinomura Y
- Journal Title
  
  Int J Oncol
  
  Volume: 39 Pages: 593-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Genome-wide profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer2011
- Author(s)
  Suzuki H, Takatsuka S, Akashi H, Yamamoto E, Nojima M, Maruyama R, Kai M, Yamano HO, Sasaki Y, Tokino T, Shinomura Y, Imai K, Toyota M
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 5646-5658
- NAID
  130004436468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo2011
- Author(s)
  Sasaki S, Ishida T, Toyota M, Ota A, Suzuki H, Takaoka A, Yasui H, Yamamoto H, Takagi H, Maeda M, Seito T, Tsujisaki M, Shinomura Y, Imai K
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer.2011
- Author(s)
  Yamamoto E, Suzuki H, Takamaru H, Yamamoto H, Toyota M, Shinomura Y.
- Journal Title
  
  Digestion 83
  
  Pages: 241-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN452011
- Author(s)
  Li H, Adachi Y, Yamamoto H, Min Y, Ohashi H, Ii M, Arimura Y, Endo T, Lee CT, Carbone DP, Imai K, Shinomura Y
- Journal Title
  
  Cancer
  
  Volume: 117 Pages: 3135-3147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659400
[Journal Article] Profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer2011
- Author(s)
  Suzuki H, Takatsuka S, Akashi H, Yamamoto E, Nojima M, Maruyama R, Kai M, Yamano H, Sasaki Y, Tokino T, Shinomura Y, Imai K, Toyota M.
- Journal Title
  
  Cancer Res.
  
  Volume: 71 Pages: 5646-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers.2010
- Author(s)
  Adachi Y, Yamamoto H, Ohashi H, Endo T, Carbone DP, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol 16
  
  Pages: 5779-5789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
- Author(s)
  Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JP, Shinomura Y, Tokino T, Toyota M.
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 342-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.2010
- Author(s)
  Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, Kimura T, Kudo T, Harada E, Sugai T, Takamaru H, Niinuma T, Maruyama R, Yamamoto H, Tokino T, Imai K, Toyota M, Shinomura Y.
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 2066-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointestinal stromal tumors.2010
- Author(s)
  Igarashi S, Suzuki H, Niinuma T, Shimizu H, Nojima M, Iwaki H, Nobuoka T, Nishida T, Miyazaki Y, Takamaru H, Yamamoto E, Yamamoto H, Tokino T, Hasegawa T, Hirata K, Imai K, Toyota M, Shinomura Y.
- Journal Title
  
  Clin Cancer Res 16
  
  Pages: 5114-5123
- NAID
  130004927691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers.2010
- Author(s)
  Wang Y, Adachi Y, Imsumran A, Yamamoto H, Piao W, Li H, Ii M, Arimura Y, Park MY, Kim D, Lee CT, Carbone DP, Imai K, Shinomura Y.
- Journal Title
  
  J Gastroenterol 45
  
  Pages: 159-170
- NAID
  10027214385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] IGFBP7 is p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
- Author(s)
  Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JPJ, Shinomura Y, Tokino T, Toyota M
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 342-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematological malignancies.2009
- Author(s)
  Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M
- Journal Title
  
  Cancer Res 69
  
  Pages: 8447-8454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity.2009
- Author(s)
  Yabana T, Arimura Y, Tanaka H, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Adachi Y, Sasaki Y, Isobe M, Fujimiya M, Imai K, Shinomura Y.
- Journal Title
  
  J Pathol 218
  
  Pages: 350-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Integrated analysis of genetic and epigenetic alterations in cancer.2009
- Author(s)
  Toyota M, Suzuki H, Yamamoto E, Yamano H, Imai K, Shinomura Y
- Journal Title
  
  Epigenomics 1
  
  Pages: 291-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.2009
- Author(s)
  Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol 15
  
  Pages: 3865-3873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma.2009
- Author(s)
  Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
- Journal Title
  
  Clin Cancer Res 15
  
  Pages: 4356-4364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy.2009
- Author(s)
  Toyota M, Suzuki H, Yamashita T, Hirata K, Shinomura Y, Tokino T, Imai K
- Journal Title
  
  Cancer Sci 100
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma.2009
- Author(s)
  Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y.
- Journal Title
  
  Clin Cancer Res 15
  
  Pages: 4356-4364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.2009
- Author(s)
  Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M.
- Journal Title
  
  Cancer Res 69
  
  Pages: 8447-8454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.2009
- Author(s)
  Yamaoka S, Yamamoto H, Nosho K, Taniguchi H, Adachi Y, Sasaki S, Arimura Y, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol 15
  
  Pages: 5579-5585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.2009
- Author(s)
  Asano K, Matsushita T, Umeno J, Hosono N, Takahashi A, Kawaguchi T, Matsumoto T, Matsui T, Kakuta Y, Kinouchi Y, Shimosegawa T, Hosokawa M, Arimura Y, Shinomura Y, Kiyohara Y, Tsunoda T, Kamatani N, Iida M, Nakamura Y, Kubo M.
- Journal Title
  
  Nat Genet 41
  
  Pages: 1325-1329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Cancer epigenomics : implications of DNA methylation in personalized cancer therapy.2009
- Author(s)
  Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y.
- Journal Title
  
  Cancer Sci 100
  
  Pages: 787-791
- NAID
  10025145027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009
- Author(s)
  Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  J Biol Chem 284
  
  Pages: 872-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.2008
- Author(s)
  Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB.
- Journal Title
  
  Cancer Res 68
  
  Pages: 2570-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008
- Author(s)
  Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M.
- Journal Title
  
  Pharmacogenomics 9
  
  Pages: 1917-1928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008
- Author(s)
  Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y.
- Journal Title
  
  J Gastroenterol 43
  
  Pages: 378-389
- NAID
  10021268741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka Y, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Carcinogenesis 29
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y.
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008
- Author(s)
  Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T.
- Journal Title
  
  Cancer Sci 99
  
  Pages: 958-966
- NAID
  10024006089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T.
- Journal Title
  
  Cancer Res 68
  
  Pages: 4123-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008
- Author(s)
  Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
- Journal Title
  
  J. Gastroenterol 43
  
  Pages: 378-389
- NAID
  10021268741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008
- Author(s)
  Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
- Journal Title
  
  Pharmacogenomics 9
  
  Pages: 1917-1928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008
- Author(s)
  Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
- Journal Title
  
  Cancer Sci 99
  
  Pages: 958-966
- NAID
  10024006089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Identification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members.2008
- Author(s)
  Sasaki Y, Ohshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Mol Cancer Res 6
  
  Pages: 395-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] A requirement for DICER to maintain full promoter CpG Island hypermethylation in human cancer cells.2008
- Author(s)
  Ting A, Suzuki H, Cope L, Schuebel K, Lee B, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
- Journal Title
  
  Cancer Res 68
  
  Pages: 2570-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T.
- Journal Title
  
  Carcinogenesis 29
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Res 68
  
  Pages: 4123-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma.2008
- Author(s)
  Nosho K, Yamamoto H, Takahashi T, Mikami M, Hizaki K, Maehata T, Taniguchi H, Yamaoka S, Adachi Y, Itoh F, Imai K, Shinomura Y.
- Journal Title
  
  Hum Pathol 39
  
  Pages: 767-775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] The hsitone deacetylase inhibitor FK288 enhances adenovirus-mediated p53 family gene therapy in cancer models.2008
- Author(s)
  Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Mol Cancer Ther 7
  
  Pages: 779-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.2008
- Author(s)
  Oki M, Yamamoto H, Taniguchi H, Adachi Y, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol 14
  
  Pages: 5650-5656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008
- Author(s)
  Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
- Journal Title
  
  British J Cancer 98
  
  Pages: 1147-1156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] DNA hypermethylation contributes incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.2008
- Author(s)
  Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
- Journal Title
  
  Gastroenterol 135
  
  Pages: 142-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Imai K, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
- Author(s)
  Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Sci 98
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007
- Author(s)
  Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
- Journal Title
  
  Oncogene 26
  
  Pages: 4699-4713
- NAID
  130004927598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007
- Author(s)
  Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Carcinogenesis 28
  
  Pages: 2459-2466
- NAID
  130004436413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007
- Author(s)
  Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Itoh F, Tokino T
- Journal Title
  
  Clin Cancer Res 13
  
  Pages: 4786-4794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus.2006
- Author(s)
  Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Cancer 106
  
  Pages: 1467-1479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Comparative genome analysis identified the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006
- Author(s)
  Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Res 66
  
  Pages: 4574-4583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Enhanced expression of suppressor of cytokine signalling-1 in the liver of chronic hepatitis C : possible involvement in resistance to interferon therapy.2005
- Author(s)
  Imanaka K, Tamura S(2番目), Kiso S(5番目), Shinomura Y(10番目)他6名
- Journal Title
  
  J Viral Hepat. 12(2)
  
  Pages: 130-138
- Data Source
  KAKENHI-PROJECT-16590593
[Journal Article] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.2005
- Author(s)
  Yamamoto K, Tamura S (11番目), Shinomura Y(14番目)(他11名)
- Journal Title
  
  Gut 54(6)
  
  Pages: 742-744
- Data Source
  KAKENHI-PROJECT-16590593
[Journal Article] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.2005
- Author(s)
  Yamamoto K, Tamura S (11番目), Shinomura Y(14番目)(他11名).
- Journal Title
  
  Gut 54.6
  
  Pages: 742-744
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590593
[Journal Article] Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells2005
- Author(s)
  Osamu Kishida, Yasuhisa Shinomura(11番目)(他9名)
- Journal Title
  
  Cancer Chemotherapy and Pharmacology 55(4)
  
  Pages: 393-403
- Data Source
  KAKENHI-PROJECT-16590593
[Journal Article] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.2005
- Author(s)
  Yamamoto K, Tamura S, Shinomura Y, et al.
- Journal Title
  
  Gut 54(6)
  
  Pages: 742-744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590593
[Journal Article] An enhanced expression of suppressor of cytokine signaling-1 in the liver of chronic hepatitis C : a possible involvement in resistance to interferon therapy.2005
- Author(s)
  Imanaka K, Tamura S, Fukui K, Ito N, Kiso S, Imai Y, Naka T, Kishimoto T, Kawata S, Shinomura Y.
- Journal Title
  
  J Viral Hepat. 12(2)
  
  Pages: 130-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells2005
- Author(s)
  Osamu Kishida, Yasuhisa Shinomura, et al.
- Journal Title
  
  Cancer Chemotherapy and Pharmacology 55(4)
  
  Pages: 393-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590593
[Journal Article] Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells2005
- Author(s)
  Osamu Kishida, Yasuhisa Shinomura(11番目) (他9名)
- Journal Title
  
  Cancer Chemotherapy and Pharmacology 55.4
  
  Pages: 393-403
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590593
[Journal Article] Gefitinib (‘Iressa', ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.2005
- Author(s)
  Kishida O, Miyazaki Y, Murayama Y, Ogasa M, Miyazaki T, Yamamoto T, Watabe K, Tsutsui S, Kiyohara T, Shimomura I, Shinomura Y.
- Journal Title
  
  Cancer Chemoth.Pharm. 55(4)
  
  Pages: 393-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Changes in gene expression associated with the loss of the interstitial cells of Cajal in the gastric fundus of W/W(V) mice.2004
- Author(s)
  Shinomura Y.
- Journal Title
  
  J Gastroenterol. 39(3)
  
  Pages: 304-305
- NAID
  10012843131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.2004
- Author(s)
  Murayama Y, Shinomura Y(13番目)他11名
- Journal Title
  
  J Cell Sci. 117
  
  Pages: 3379-3388
- Data Source
  KAKENHI-PROJECT-16590593
[Journal Article] CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.2004
- Author(s)
  Murayama Y, Miyagawa J, Oritani K, Yoshida H, Yamamoto K, Kishida O, Miyazaki T, Tsutsui S, Kiyohara T, Miyazaki Y, Higashiyama S, Matsuzawa Y, Shinomura Y
- Journal Title
  
  J Cell Sci. 117(Pt 15)
  
  Pages: 3379-3388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Distinct roles for the SgIGSF adhesion molecule and c-kit receptor tyrosine kinase in the interaction between mast cells and the mesentery.2004
- Author(s)
  Watabe K, Ito A, Koma Y, Wakayama T, Iseki S, Shinomura Y, Kitamura Y.
- Journal Title
  
  Biochem Biophys Res Commun. 324(2)
  
  Pages: 782-788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Basic Fibroblast Growth Factor Promotes the Trans-differentiation of Mouse Bone Marrow Cells into Hepatic Lineage Cells via Multiple Liver-enriched Transcription Factors.2004
- Author(s)
  Saji Y, Tamura S, Yoshida Y, Kiso S, Saeki Iizuka A, Matsumoto H, Kawasaki T, Kamada Y, Matsuzawa Y, Shinomura Y.
- Journal Title
  
  J.Hepatol. 41(4)
  
  Pages: 545-550
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha.2004
- Author(s)
  Ohashi A, Kinoshita K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y, Hirota S.
- Journal Title
  
  Int J Cancer. 111(3)
  
  Pages: 317-321
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumors from neurofibromatosis type 1 patients.2004
- Author(s)
  Kinoshita K, Hirota S, Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y
- Journal Title
  
  J Pathol. 202(1)
  
  Pages: 80-85
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Changes in gene expression associated with the loss of the interstitial cells of Cajal in the gastric fundus of W/W(V) mice2004
- Author(s)
  Shinomura Y
- Journal Title
  
  J Gastroenterol 39(3)
  
  Pages: 304-305
- NAID
  10012843131
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Changes in gene expression associated with the loss of the interstitial cells of Cajal in the gastric fundus of W/W(V) mice.2004
- Author(s)
  Shinomura Y.
- Journal Title
  
  J.Gastroenterol. 39(3)
  
  Pages: 304-305
- NAID
  10012843131
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Helicobacter pylori-induced enlarged-fold gastritis is associated with increased mutagenicity of gastric juice, increased oxidative DNA damage, and an increased risk of gastric carcinoma.2003
- Author(s)
  Nishibayashi H, Kanayama S, Kiyohara T, Yamamoto K, Miyazaki Y, Yasunaga Y, Shinomura Y, Takeshita T, Takeuchi T, Morimoto K, Matsuzawa Y
- Journal Title
  
  J Gastroenterol Hepatol. 18(12)
  
  Pages: 1384-1391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.2003
- Author(s)
  Kamada Y, Tamura S, Kiso S, Matsumoto H, Saji Y, Yoshida Y, Fukui K, Maeda N, Nishizawa H, Nagaretani H, Okamoto Y, Kihara S, Miyagawa J, Shinomura Y, Funahashi T, Matsuzawa Y
- Journal Title
  
  Gastroenterology. 125(6)
  
  Pages: 1796-1807
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] c-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors.2003
- Author(s)
  Kinoshita K, Isozaki K, Hirota S, Nishida T, Chen H, Nakahara M, Nagasawa Y, Ohashi A, Shinomura Y, Kitamura Y, Matsuzawa Y
- Journal Title
  
  J Gastroenterol Hepatol. 18(2)
  
  Pages: 147-151
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor gene in gastrointestinal stromal tumors.2003
- Author(s)
  Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, Kitamura Y
- Journal Title
  
  Gastroenterology. 125(3)
  
  Pages: 660-667
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Gastrin activates nuclear factor kappaB (NFkappaB) through a protein kinase C dependent pathway involving NFkappaB inducing kinase, inhibitor kappaB (IkappaB) kinase, and tumor necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor.2003
- Author(s)
  Ogasa M, Miyazaki Y, Hiraoka S, Kitamura S, Nagasawa Y, Kishida O, Miyazaki T, Kiyohara T, Shinomura Y, Matsuzawa Y
- Journal Title
  
  Gut. 52(6)
  
  Pages: 813-819
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumors.2003
- Author(s)
  Kinoshita K, Isozaki K, Tsutsui S, Kitamura S, Hiraoka S, Watabe K, Nakahara M, Nagasawa Y, Kiyohara T, Miyazaki Y, Hirota S, Nishida T, Shinomura Y, Matsuzawa Y
- Journal Title
  
  Eur J Gastroenterol Hepatol. 15(11)
  
  Pages: 1189-1193
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors.2003
- Author(s)
  Chen H, Isozaki K, Kinoshita K, Ohashi A, Shinomura Y, Matsuzawa Y, Kitamura Y, Hirota S
- Journal Title
  
  Int J Cancer. 105(1)
  
  Pages: 130-135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Dose-dependent and time-limited proliferation of cultured murine interstitial cells of Cajal in response to stem cell factor.2002
- Author(s)
  Nakahara M, Isozaki K, Vanderwinden JM, Shinomura Y, Kitamura Y, Hirota S, Matsuzawa Y
- Journal Title
  
  Life Sci. 70(20)
  
  Pages: 2367-2376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumors.2002
- Author(s)
  Chen H, Hirota S, Isozaki K, Sun H, Ohashi A, Kinoshita K, O'Brien P, Kapusta L, Dardick I, Obayashi T, Okazaki T, Shinomura Y, Matsuzawa Y, Kitamura Y
- Journal Title
  
  Gut. 51(6)
  
  Pages: 793-796
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.2002
- Author(s)
  Hirota S, Nishida T, Isozaki K, Taniguchi M, Nishikawa K, Ohashi A, Takabayashi A, Obayashi T, Okuno T, Kinoshita K, Chen H, Shinomura Y, Kitamura Y.
- Journal Title
  
  Gastroenterology 122(5)
  
  Pages: 1493-1499
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer.2002
- Author(s)
  Murayama Y, Miyagawa J, Shinomura Y, Kanayama S, Isozaki K, Yamamori K, Mizuno H, Ishiguro S, Kiyohara T, Miyazaki Y, Taniguchi N, Higashiyama S, Matsuzawa Y
- Journal Title
  
  Int.J.Cancer 98(4)
  
  Pages: 505-513
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Epidermal growth factor inhibits the growth of TE8 esophageal cancer cells through the activation of STAT1.2002
- Author(s)
  Ichiba M, Miyazaki Y, Kitamura S, Kiyohara T, Shinomura Y, Matsuzawa Y
- Journal Title
  
  J Gastroenterol. 37(7)
  
  Pages: 498-503
- NAID
  50000581934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Deficiency of KIT positive cells in the colon of patients with diabetes mellitus.2002
- Author(s)
  Nakahara M, Isozaki K, Hirota S, Vanderwinden JM, Takakura R, Kinoshita K, Miyagawa J, Chen H, Miyazaki Y, Kiyohara T, Shinomura Y, Matsuzawa Y
- Journal Title
  
  J.Gastroenterol.Hepatol. 17(6)
  
  Pages: 666-670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Enhanced macrophage responsiveness to lipopolysaccharide and CD40 stimulation in a murine model of inflammatory bowel disease : IL-10-deficient mice.2002
- Author(s)
  Takakura R, Kiyohara T, Murayama Y, Miyazaki Y, Miyoshi Y, Shinomura Y, Matsuzawa Y
- Journal Title
  
  Inflamm Res. 51(8)
  
  Pages: 409-415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Epigenetic inactivation of interferon regulatory factor genes in gastric cancer.
- Author(s)
  Yamashita M, Toyota M, Suzuki H, Nojima M, Yamamoto E, Kamimae S, Watanabe Y, Kai M, Akashi H, Maruyama R, Sasaki Y, Yamano H, Sugai T, Shinomura Y, Imai K, Tokino T, Itoh F
- Journal Title
  
  Cancer Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Patent] 大腸癌を治療および／または診断するための組成物ならびにその利用2013
- Inventor(s)
  篠村　恭久, 能正勝彦, 山本博幸, 鈴木拓
- Industrial Property Rights Holder
  北海道公立大学法人　札幌医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-06-14
- Data Source
  KAKENHI-PROJECT-23390200
[Patent] 腸癌を治療および/または診断するための組成物ならびにその利用2013
- Inventor(s)
  篠村恭久, 能正勝彦, 山本博幸, 鈴木拓
- Industrial Property Rights Holder
  北海道公立大学法人札幌医科大学
- Industrial Property Number
  2013-126021
- Filing Date
  2013-06-14
- Data Source
  KAKENHI-PROJECT-23390200
[Patent] 癌の検出方法および検出用キット、ならびに癌治療剤.2008
- Inventor(s)
  鈴木拓, 豊田実, 篠村恭久, 他2名
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2008-121671
- Filing Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-20390210
[Patent] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006
- Inventor(s)
  豊田実, 篠村恭久, 他
- Industrial Property Rights Holder
  北海道聖マリアンヌ医科大学
- Industrial Property Number
  2006-134878
- Filing Date
  2006-05-15
- Data Source
  KAKENHI-PROJECT-18390221
[Presentation] 大腸腫瘍の発育進展におけるFusobacterium属の役割とマイクロサテライト不安定性との関連2017
- Author(s)
  能正勝彦、篠村恭久
- Organizer
  第3回Gut microbiota研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08954
[Presentation] A combination of the anti-fibroblast growth factor receptor 1 monoclonal antibody and interferon-a/b supresses human hepatic cancer cells in vitro and in vivo2014
- Author(s)
  Kato Y, Hiromi H, Tujisaki M, Matsune T, Sasaki S, Hinoda Y, Shinomura Y, Imai K
- Organizer
  41 Congress of the International Society of Oncology and Biomarkers
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 高齢者の大腸鋸歯状病変における臨床病理学的特徴と分子異常の検討2014
- Author(s)
  能正勝彦，五十嵐央祥，伊藤美樹，内藤崇史，吉井新二，須河恭敬，三上雅史，高橋宏明，久須美貴哉，細川正夫，奥田博介，藤田昌弘，青木敬則，山本英一郎，足立　靖，沖田憲司，平田公一，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第10回日本消化管学会総会学術集会
- Place of Presentation
  福島ビューホテル（福島市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 表在型食道胃接合部癌における分子生物学的異常の解析2014
- Author(s)
  伊藤美樹，能正勝彦，五十嵐央祥，内藤崇史，三橋　慧，田沼徳真，山本佳子，高橋宏明，細川正夫，山本博幸，篠村恭久
- Organizer
  第10回日本消化管学会総会学術集会
- Place of Presentation
  福島ビューホテル（福島市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] p53 family network and tumor suppression2014
- Author(s)
  Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
- Organizer
  The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
- Place of Presentation
  Zhangjiajie, China
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Association between EBV infection and HER2 expression in gastric cancer2013
- Author(s)
  Mitsuhashi K, Sukawa Y, Nakazawa M, Naito T, Ito M, Igarashi H, Kunimoto H, Nosho K, Adachi Y, Yamamoto H, Takada K, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸鋸歯状病変におけるmicroRNA-31の役割2013
- Author(s)
  能正勝彦，五十嵐央祥，伊藤美樹，内藤崇史，三橋　慧，須河恭敬，丸山玲緒，山本英一郎，荻野周史，鈴木　拓，今井浩三，山本博幸，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸癌の新規バイオマーカー探索を目指したEGFR下流シグナルを制御するマイクロRNAの検討2013
- Author(s)
  能正勝彦，五十嵐央祥，伊藤美樹，内藤崇史，三橋　慧，野島正寛，山本英一郎，吉井新二，奥田博介，高橋宏明，久須美貴哉，細川正夫，沖田憲司，平田公一，丸山玲緒，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第79回大腸癌研究会
- Place of Presentation
  梅田スカイビル（大阪市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Associations among the HER2 signal-related factors thought to be predictive factors for the effectiveness of trastuzumab therapy in gastric cancer2013
- Author(s)
  Yamamoto H, Sukawa Y, Nakazawa M, Sumioka W, Watanabe Y, Maehata T, Morita R, Yoshida Y, Ishigooka S, Ozawa S, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Imai K, Shinomura Y, Itoh F
- Organizer
  The 4th JCA-AACR Special Joint Conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club & Resorts, Urayasu, Japan
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Analysis of the molecular features of elderly colorectal cancer patients using a large Japanese cohort study and the lmportance of sessile serrated adenoma/polyp (SSA/P) as a precursor lesion2013
- Author(s)
  Igarashi H, Nosho K, Ito M, Naito T, Mitsuhashi K, Sukawa Y, Mikami M, Yamamoto E, Nakazawa M, Sumioka W, Okuda H, Takahashi H, Kusumi T, Hosokawa M, Nojima M, Okita K, Suzuki H, Yamamoto H, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸鋸歯状病変におけるInsulin-like growth factor2（IGF2）differentially methylated region (DMR) 0メチル化レベルの解析―発癌機構の解明を目指して―2013
- Author(s)
  能正勝彦，伊藤美樹，五十嵐央祥，内藤崇史，三橋　慧，須河恭敬，足立　靖，吉井新二，鈴木　拓，山本博幸，荻野周史，篠村恭久
- Organizer
  第50回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] microRNA-34b/c異常メチル化率測定による胃癌の異時性多発リスク予測2013
- Author(s)
  鈴木　亮，山本英一郎，鈴木　拓，野島正寛，丸山玲緒，能正勝彦，山本博幸，山野泰穂，菅井　有，篠村恭久
- Organizer
  第110回日本内科学会総会講演会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Analysis of the insulin-like growth factor 2 (IGF2) differentially methylated region (DMR) 0 hypomethylation in carcinogenesis of colorectal serrated lesions2013
- Author(s)
  Nosho K, Yoshii S, Baba Y, Igarashi H, Ito M, Naito T, Sukawa Y, Mikami M, Takahashi T, Nakazawa M, Sumioka W, Takahashi H, Hosokawa M, Suzuki H, Adachi Y, Yamamoto H, Imai K, Ogino S, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 胃癌におけるトラスツズマブ治療の効果予測因子となりうるHER2シグナル関連分子異常の関連の解析2013
- Author(s)
  山本博幸，須河恭敬，能正勝彦，前畑忠輝，谷口博昭，五十嵐央祥，伊藤美樹，内藤崇史，足立　靖，鈴木　拓，伊東文生，今井浩三，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大規模コホートを用いた高齢者大腸癌と大腸鋸歯状病変の分子病理学的検討2013
- Author(s)
  沼田泰尚，能正勝彦，五十嵐央祥，伊藤美樹，内藤崇史，三橋　慧，三上雅史，高橋大賀，吉井新二，高橋宏明，久須美貴哉，細川正夫，山本英一郎，山下健太郎，有村佳昭，青木敬則，野村昌史，山本博幸，平田公一，篠村恭久
- Organizer
  第86回日本消化器内視鏡学会総会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸癌におけるmicroRNA-31発現とBRAF遺伝子変異・抗EGFR抗体薬感受性との関連性2013
- Author(s)
  五十嵐央祥，能正勝彦，伊藤美樹，野島正寛，吉井新二，丸山玲緒，内藤崇史，三橋　慧，山本英一郎，足立　靖，三上雅史，高橋宏明，奥田博介，細川正夫，沖田憲司，平田公一，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第33回日本分子腫瘍マーカー研究会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 腸癌におけるLINE-1メチル化レベルとmicroRNA発現を標的とした診断・個別化治療への応用2013
- Author(s)
  能正勝彦, 篠村恭久
- Organizer
  第9回日本消化管学会総会学術集会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 日本人の高齢者における大腸癌および大腸鋸歯状腺腫の分子生物学的特徴2013
- Author(s)
  三橋　慧，能正勝彦，内藤崇史，松永康孝，伊藤美樹，五十嵐央祥，須河恭敬，山本英一郎，丸山玲緒，足立　靖，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Analysis of the genome-wide DNA methylation level in colorectal adenoma for detecting the precursor lesion of line extreme hypomethylated colorectal cancer2013
- Author(s)
  Nosho K, Igarashi H, Ito M, Naito T, Mitsuhashi K, Sukawa Y, Nakazawa M, Sumioka W, Yoshii S, Fujita M, Yamamoto E, Adachi Y, Baba Y, Nojima M, Maruyama R, Suzuki H, Yamamoto H, Imai K, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] microRNA-31は大腸癌におけるBRAF遺伝子変異・予後と関連する2013
- Author(s)
  五十嵐央祥，能正勝彦，伊藤美樹，内藤崇史，三橋　慧，丸山玲緒，野島正寛，山本英一郎，吉井新二，足立　靖，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Dysregulation of noncoding RNA genes and its clinical application.2013
- Author(s)
  Suzuki H, Yamamoto E, Shinomura Y and Imai K.
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference “Breakthroughs in Basic and Translational Cancer Research”
- Place of Presentation
  the Hyatt Regency Maui, Maui, HI, USA.
- Year and Date
  2013-02-21
- Invited
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] 大腸鋸歯状病変の進展および分化におけるIGF-2DMR低メチル化の役割2013
- Author(s)
  内藤崇史，能正勝彦，馬場祥史，伊藤美樹，五十嵐央祥，三橋　慧，山本英一郎，丸山玲緒，鈴木　拓，足立　靖，山本博幸，平田公一，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] The relation of LINE methylation level and macroscopic type in colorectal adenoma and pT1 colorectal cancer2013
- Author(s)
  Katsuhiko Nosho, Yasuhisa Shinomura
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 大腸腫瘍におけるKRAS、BRAF、PIK3CA 変異と相関を示すmicroRNA の同定を目指したアレイシステムによる網羅的2013
- Author(s)
  能正勝彦, 篠村恭久
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 表在型食道胃接合部癌における分子生物学的異常の解析2013
- Author(s)
  伊藤美樹，能正勝彦，五十嵐央祥，内藤崇史，三橋　慧，須河恭敬，田沼徳真，山本桂子，吉井新二，高橋宏明，細川正夫，山本博幸，篠村恭久
- Organizer
  第45回胃病態機能研究会
- Place of Presentation
  名古屋市立大学（名古屋市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 消化器癌の分子標的治療の現状と課題2013
- Author(s)
  篠村　恭久
- Organizer
  第21回日本消化器病関連学会週間（JDDW2013）
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 胃癌の異時性多発リスク予測マーカーとしてのmicroRNA-34b/c異常メチル化測定2013
- Author(s)
  鈴木　亮，山本英一郎，鈴木　拓，野島正寛，丸山玲緒，能正勝彦，山本博幸，山野泰穂，菅井　有，篠村恭久
- Organizer
  第50回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 消化器癌の分子標的治療の現状と課題2013
- Author(s)
  篠村　恭久
- Organizer
  第21回日本消化器病関連学会集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-25670371
[Presentation] microRNA-34b/cの異常メチル化は胃癌の異時性多発リスクに関与する2013
- Author(s)
  鈴木亮,篠村恭久
- Organizer
  シンポジウム6HP除菌後の病態と対応 : 第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] microRNA-34b/c異常メチル化率測定による胃癌の異時性多発リスク予測2013
- Author(s)
  鈴木亮,山本英一郎,鈴木拓,野島正寛,丸山玲緒,能正勝彦,山本博幸,山野泰穂,菅井有,篠村恭久
- Organizer
  第110回日本内科学会総会講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] Characteristics of and associations among the HER2 signal-related factors thought to be predictive factors for the effectiveness of trastuzumab therapy in gastric cancer2013
- Author(s)
  Ito M, Sukawa Y, Nosho K, Igarashi H, Naito T, Kunimoto H, Mitsuhashi K, Nakazawa M, Sumioka W, Adachi Y, Mikami M, Kawayama M, Suzuki H, Yamamoto H, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸癌の分子診断学における LINE-1 メチル化レベルの重要性と microRNA 発現の網羅的解析2012
- Author(s)
  能正勝彦, 篠村恭久
- Organizer
  JDDW2012
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.2012
- Author(s)
  鈴木拓,新沼猛,野島正寛,丸山玲緒,山本英一郎,甲斐正広,能正勝彦,山本博幸,時野隆至,今井浩三,篠村恭久
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] GISTの悪性度マーカーおよび治療標的としての non-coding RNA2012
- Author(s)
  新沼猛,鈴木拓,野島正寛,高丸博之,山本英一郎,能正勝彦,山本博幸,篠村恭久
- Organizer
  第8回日本消化管学会総会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 消化管間質腫瘍におけるmicroRNA発現プロファイル解析2012
- Author(s)
  鈴木拓,新沼猛,野島正寛,山本英一郎,丸山玲緒,山本博幸,篠村恭久
- Organizer
  第49回日本臨床分子医学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] Comprehensive analysis of the genome-wide DNA methylation and microRNA expression in gastrointestinal cancers and the identification of new biomarkers targeting those alterations2012
- Author(s)
  能正勝彦, 篠村恭久
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 胃癌におけるエピジェネティックな遺伝子異常の網羅的解析2012
- Author(s)
  高丸博之、鈴木拓、山本英一郎、神前正幸、新沼猛、丸山玲緒、豊田実、篠村恭久
- Organizer
  第8回日本消化管学会総会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] microRNA-34b/cの異常メチル化は胃癌の異時性多発リスクに関与する2012
- Author(s)
  鈴木亮,山本英一郎,鈴木拓,野島正寛,丸山玲緒,能正勝彦,山本博幸,甲斐正広,山野泰穂,菅井有,今井浩三,篠村恭久
- Organizer
  第32回日本分子腫瘍マーカー研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] 腸癌のグローバル DNA メチル化、microRNA 異常発現の解析とそれらを標的とした新規バイオマーカーの探索と大腸発癌の検討2012
- Author(s)
  能正勝彦, 篠村恭久
- Organizer
  第 23 回日本消化器癌発生学会
- Place of Presentation
  鳴門
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] GISTの悪性度マーカーおよび治療標的としてのnon-coding RNA2012
- Author(s)
  新沼猛,鈴木拓,野島正寛,高丸博之,山本英一郎,能正勝彦,山本博幸,篠村恭久
- Organizer
  第8回日本消化管学会総会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] 胃癌におけるエピジェネティックな遺伝子異常の網羅的解析2011
- Author(s)
  高丸博之、鈴木拓、山本英一郎、丸山玲緒、神前正幸、新沼猛、青木由佳、澤田武、豊田実、篠村恭久
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] 消化管間質腫瘍におけるmicroRNA発現プロファイル解析2011
- Author(s)
  新沼猛、鈴木　拓、野島正寛、高丸博之、能正勝彦、山本博幸、豊田実、篠村恭久
- Organizer
  第19回日本消化器関連学会週間
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] 消化管間質腫瘍におけるmicroRNA発現プロファイル解析2011
- Author(s)
  新沼猛,鈴木拓,野島正寛,高丸博之,能正勝彦,山本博幸,豊田実,篠村恭久
- Organizer
  第53回日本消化器病学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] 胃癌におけるエピジェジェティックな遺伝子異常の網羅的解析2011
- Author(s)
  高丸博之,鈴木拓,山本英一郎,丸山玲緒,神前正幸,新沼猛,青木由佳,澤田武,豊田実,篠村恭久
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] 胃癌におけるゲノムワイドな低メチル化と染色体不安定性2011
- Author(s)
  鈴木亮,山本英一郎,鈴木拓,丸山玲緒,山野泰穂,今井浩三,豊田実,篠村恭久
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] DNAメチル化異常の網羅的な解析による新規胃癌関連遺伝子の検索2011
- Author(s)
  高丸博之,鈴木拓,山本英一郎,新沼猛,山本博幸,有村佳昭,豊田実,篠村恭久
- Organizer
  第53回日本消化器病学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659400
[Presentation] CIMP大腸癌の起源2010
- Author(s)
  山本英一郎, 鈴木拓, 山野泰穂, 神前正幸, 甲斐正広, 菅井有, 時野隆至, 今井浩三, 篠村恭久, 豊田実
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 未分化型胃癌におけるDNAメチル化異常の解明2010
- Author(s)
  高丸博之, 鈴木拓, 山本英一郎, 新沼猛, 田沼徳真, 安井寛, 甲斐正広, 山本博幸, 豊田実, 篠村恭久
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] GISTにおけるエピジェネティックな異常とその臨床的意義2010
- Author(s)
  鈴木拓, 新沼猛, 篠村恭久
- Organizer
  第18回日本消化器病関連学会週間
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 胃癌におけるmicroRNA34b/cのエピジェネティックな不活化2010
- Author(s)
  鈴木拓, 山本英一郎, 高丸博之, 五十嵐伸一, 野島正寛, 山本博幸, 豊田実, 今井浩三, 篠村恭久
- Organizer
  第6回日本消化管学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] GISTにおけるHNE-1低メチル化と悪性度との相関2010
- Author(s)
  新沼猛, 鈴木拓, 野島正寛, 五十嵐伸一, 山本英一郎, 高丸博之, 田沼徳真, 山本博幸, 時野隆至, 今井浩三, 豊田実, 篠村恭久
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] microRNAプロセシングに関わるTARBP2遺伝子の消化管癌における変異及び機能解析2010
- Author(s)
  宮本伸樹, 山本博幸, 宮本千絵, 谷口博昭, 足立靖, 日崎恵一, 井伊正則, 田沼徳真, 須河恭敬, 佐々木茂, 有村佳昭, 篠村恭久
- Organizer
  第6回日本消化管学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 消化管間質腫瘍におけるLINE-1低メチル化と悪性度との相関2010
- Author(s)
  山本英一郎, 鈴木拓, 新沼猛, 五十嵐伸一, 山本博幸, 豊田実, 篠村恭久
- Organizer
  第21回日本消化器癌発生学会総会
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 次世代シークエンサーを用いた遺伝子転写開始点予測とエピゲノム解析への応用2010
- Author(s)
  豊田実, 鈴木拓, 野島正寛, 佐々木泰史, 篠村恭久, 時野隆至, 今井浩三
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 大腸癌においてエピジェネティックに不活化したmicroRNAの網羅的解析2009
- Author(s)
  鈴木拓, 五十嵐伸一, 高丸博之, 新沼猛, 山本博幸, 時野隆至, 今井浩三, 豊田実, 篠村恭久
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 多発胃癌背景胃粘膜における異常メチル化2009
- Author(s)
  山本英一郎, 豊田実, 鈴木拓, 山本博幸, 山野泰穂, 菅井有, 今井浩三, 篠村恭久
- Organizer
  第20回日本消化器癌発生学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 新規エピゲノム解析法の開発と消化器癌発生の分子機構2009
- Author(s)
  豊田実, 鈴木拓, 山本英一郎, 山野泰穂, 篠村恭久
- Organizer
  第5回日本消化管学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 胃癌の進展におけるラミニンβ3とγ2の共発現の役割2009
- Author(s)
  井伊正則, 山本博幸, 足立靖, 谷口博昭, 日崎恵一, 大橋広和, 田沼徳真, 國本浩明, 阿久津典之, 佐々木茂, 有村佳昭, 今井浩三, 篠村恭久
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 大腸癌におけるIGFBP7のメチル化とCIMPとの相関2009
- Author(s)
  鈴木拓, 五十嵐伸一, 高丸博之, 新沼猛, 山本英一郎, 野島正寛, 山本博幸, 豊田実, 今井浩三, 篠村恭久
- Organizer
  第20回日本消化器癌発生学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] JCウイルスT抗原発現陽性胃癌のジェネティックおよびエピジェネティックな異常2008
- Author(s)
  山本博幸, 山岡聡, 宮本千絵, 井伊正則, 日崎恵一, 田沼徳真, 宮本伸樹, 奥田博介, 足立靖, 佐々木茂, 有村佳昭, 今井浩三, 篠村恭久
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] ゲノムワイドな低メチル化を指標とした胃癌の診断と発癌リスク予測への応用2008
- Author(s)
  山本英一郎, 豊田実, 篠村恭久
- Organizer
  第16回日本消化器関連学会週間
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] IGF-I受容体標的治療はマトリライシンの抑制を介してヒト消化器癌の浸潤を抑制する2008
- Author(s)
  足立靖, 山本博幸, 井伊正則, 有村佳昭, 遠藤高夫, 加藤康夫, 今井浩三, 篠村恭久
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 皺壁肥大型胃炎におけるゲノムワイドな低メチル化とCpGアイランド高メチル化の関連2008
- Author(s)
  山本英一郎, 豊田実, 鈴木拓, 野島正寛, 丸山玲緒, 五十嵐伸一, 時野隆至, 今井浩三, 篠村恭久
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] Epigenetic silencing of genes involved in signaling pathway. Symposium2007
- Author(s)
  Toyota M, Suzuki H, Shinomura Y, Tokino T, Imai K
- Organizer
  The 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Frequent epigenetic inactivation of DICKKOPF family genes in gastrointestinal tumors.2007
- Author(s)
  Suzuki H, Toyota M, Maruyama R, Imai K, Shinomura Y
- Organizer
  35th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Plaque, Czech Republic
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
- Author(s)
  Toyota M, Suzuki H, Maruyama R, Akino K, Watanabe Y, Sasaki Y, Imai K, Tokino T, Shinomura Y
- Organizer
  98th Annual Meeting of American Association for Cancer Research.
- Place of Presentation
  Los Angeles
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Epigenetic inactivation of TCF2 in human tumors2006
- Author(s)
  Toyota M, Terasawa K, Sagae S, Ogi K, Suzuki H, Maruyama R, Shinomura Y, Saito T, Imai K, Tokino T
- Organizer
  97th Annual Meeting of American Association for Cancer Research
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] DNA methylation changes in cancer: application to diagnosis and therapy. Symposium2006
- Author(s)
  Toyota M, Suzuki H, Shinomura Y, Imai K
- Organizer
  34th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Pasadena, USA
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] 消化管間質腫瘍におけるmicroRNA遺伝子のエピジェネティックな制御
- Author(s)
  新沼猛, 篠村恭久, 鈴木拓
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25670371
[Presentation] 消化管間質腫瘍の再発に関するmicroRNAの解析
- Author(s)
  伊早坂舞, 篠村恭久, 鈴木拓
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25670371

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164. 鈴木亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
165. 山本正幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
166. 苗代康可

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
167. 山下健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
168. 平田公一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
169. 菅井有

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
170. 安田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
171. 伊東文生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinomura Yasuhisa 篠村 恭久

SHINOMURA Yasuhisa 篠村 恭久

篠村 泰久 シノムラ ヤスヒサ

篠村 恭久 シノムラ ヤスヒサ

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Genome and epigenome analysis of early esophageal cancer and the development of molecular diagnosis using endoscopic washPrincipal Investigator

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Analysis of long non-coding RNAs that predict biological malignancy in GISTPrincipal Investigator

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Analysis of the abnormalities of microRNA and epigenome and the clinical application in gastroenterological cancersPrincipal Investigator

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Epigenomic analysis of gastrointestinal cancer stromaPrincipal Investigator

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Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterationsPrincipal Investigator

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消化管間質腫瘍におけるマイクロRNA発現異常の解明Principal Investigator

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Development of diagnostic methods of gastrointestinal cancer using integrated analysis of nuclear moleculesPrincipal Investigator

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Shinomura Yasuhisa 篠村恭久

SHINOMURA Yasuhisa 篠村恭久

篠村泰久シノムラヤスヒサ

篠村恭久シノムラヤスヒサ