TOYOTA Minoru 豊田実

… Alternative Names

豊田実トヨタミノル

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Researcher Number	70270676
Other IDs
Affiliation (based on the past Project Information) *help	2013: 札幌医科大学, 医学部生化学, 教授 2008 – 2011: Sapporo Medical University, 医学部, 教授 2004 – 2007: School of Medicine, Assistant Professor, 医学部, 講師 2001 – 2003: 札幌医科大学, 医学部, 助手 1995 – 1996: 国立がんセンター研究所, 発がん研究部, 研究員
Review Section/Research Field	Principal Investigator Gastroenterology / Biological Sciences / Gastroenterology / Carcinogenesis Except Principal Investigator Gastroenterology / Gastroenterology / Clinical oncology / Obstetrics and gynecology
Keywords	Principal Investigator DNAメチル化 / エピジェネティクス / クロマチン / ヒストン / Epigenetics / MCA / DNA methylation / アポトーシス / 癌抑制遺伝子 / がん抑制遺伝子 … More / ヒストンアセチル化 / エピゲノム / 消化器癌 / 機能性RNA / メチル化 / ubiquitin / Molecular target therapy / histone / methylation / ユビキチン / 分子標的治療 / メチレーション / epigenetics / tumor suppressor gene / chromatin / histone acetyiation / Tumor marker / inflammatory bowel disease / DNA methylations / 前癌病変 / 炎症 / 分子マーカー / 腫瘍マーカー / 炎症性腸疾患 / Tumor suppressor gene / Chromatin / Histone acetvlation / 細胞周期 / ヒルトンアセチル化 / エビジェネティクス / 発癌 / 転写 / 個別化医療 / オーダーメード医療 / RNA干渉 / ヒストンメチル化 / 遺伝子診断 / エピジェネテクス / 遺伝子発現 … More Except Principal Investigator エピジェネティクス / メチル化 / 消化器癌 / 分子標的治療 / 前癌病変 / 遺伝子不安定性 / 遺伝子診断 / ヒストン修飾 / DNAメチル化 / prediction of cancer risk / genetic diagnosis / epigenetics / methylation / gastrointestinal cancer / 遺伝子変異 / 発癌リスク予測 / Gastrointestinal cancer / Molecular target therapy / Epigenetics / DNA methylation / Genetic instability / 癌発生 / メチル化異常 / ヒストン / 消火器癌 / 消化管 / エピゲノム / 糖鎖 / 下部消化管学(小腸、大腸) / 脳腫瘍 / ポリコーム複合体 / グリオブラストーマ / ポリコーム / がん幹細胞 / 分子標的 / 腫瘍マーカー / 遺伝子発現 / 個別化医療 / 微小管阻害剤(タキサン系抗癌剤) / CyclinB / 細胞周期M期 / BRAC pathway / Fanconi-anemia / ASC / TMS1 / アポトーシス / エピジェネティクスの異常 / TCF2 / MCA法 / 卵巣癌 / エピジェネティックス / 発がん感受性 / aberrant crypt focus / microsatellite / 乳がん / PhIP / LOH / 染色体マッピング / PP2AB / Brca-2 / Brca-1 Less

転写後レベルでのエピジェネティックな遺伝子調節機構と発癌における役割Principal Investigator
- Principal Investigator
  
  豊田実
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Sapporo Medical University
Epigenetic plasticity as a novel target for cancer treatment
- Principal Investigator
  
  KONDO Yutaka
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Aichi Cancer Center Research Institute
Epigenetically regulated tissue repair mechanism in gastrointestinal tract
- Principal Investigator
  
  KAWAMURA I. Yuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Research Institute, International Medical Center of Japan
Development of a novel method for epigenome analysis and application to cancer diagnosis and order made therapyPrincipal Investigator
- Principal Investigator
  
  TOYOTA Minoru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Development of diagnostic methods of gastrointestinal cancer using integrated analysis of nuclear molecules
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Role of DNA methylation and altered histone modification in development and progression of cancerPrincipal Investigator
- Principal Investigator
  
  TOYOTA Minoru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy
- Principal Investigator
  
  IMAI Kohzoh
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Tailor-made therapy of gastrointestinal cancer targeting aberrant modification of biological moleculesPrincipal Investigator
- Principal Investigator
  
  TOYOTA Minoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
卵巣癌におけるエピジェネティクスの異常の解析と治療への応用についての研究
- Principal Investigator
  
  藤井美穂
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Sapporo Medical University
Development of a novel therapy for gastrointestinal cancer using epigenetic alterations as a target.Principal Investigator
- Principal Investigator
  
  TOYOTA Minoru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
The mechanism of DNA methylation dependent gene silencing in gastrointestinal cancerPrincipal Investigator
- Principal Investigator
  
  TOYOTA Minoru
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Aberrant methylation of inflammatory bowel disease and its application to risk assessment of cancerPrincipal Investigator
- Principal Investigator
  
  TOYOTA Minoru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Microsatellite instability and aberrant methylation in gastrointestinal cancer and its application to molecular target therapy
- Principal Investigator
  
  IMAI Kohzoh
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
発がん過程における遺伝子変異
- Principal Investigator
  
  長尾美奈子
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book Patent

[Book] Inflammation-related aberrant patterns of DNA methylation: detection and role in epigenetic deregulation of cancer cell transcriptome. Methods in Mol. Biol: Inflammation and cancer.(Edited by Kozlov SV)2009
- Author(s)
  Suzuki H, Toyota M, Kondo Y, Shinomura Y
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-17013073
[Book] エピジェネティクス-メチル化とヒストン修飾. がんの分子標的治療.(鶴尾隆. 編集.)2008
- Author(s)
  今井浩三、豊田実
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-19390201
[Book] CHFR as a potential anticancer target. (Edited by Dai W, Cancer Drug Discovery and Development Checkpoint Response in Cancer Therapy.)2008
- Author(s)
  Toyota M, Kashima L, Tokino T
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-17013073
[Book] 消化管病理標本の読み方改訂2版.2008
- Author(s)
  豊田実, 他
- Total Pages
  228
- Publisher
  日本メディカルセンター.
- Data Source
  KAKENHI-PROJECT-17109008
[Book] CHFR as a potential anticancer target. Cancer Drug Discovery and Development Checkpoint Response in Cancer Therapy2008
- Author(s)
  Toyota M, Kashima L, Tokino T.
- Total Pages
  314
- Publisher
  Edited by Dai W, Humana Press, NJ, USA
- Data Source
  KAKENHI-PROJECT-19390201
[Book] 消化管と遺伝子異常. 消化管病理標本の読み方改訂2版.(中村眞一. 編集.)2008
- Author(s)
  豊田実、今井浩三、篠村恭久
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-19390201
[Book] 消化管病理標本の読み方改訂2版.2008
- Author(s)
  豊田実, 他
- Total Pages
  228
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-19390201
[Book] エピジェネティクス-メチル化とヒストン修飾. がんの分子標的治療2008
- Author(s)
  今井浩三、豊田実, 鶴尾隆. (編集)
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-17109008
[Book] 消化管と遺伝子異常. 消化管病理標本の読み方改訂2版2008
- Author(s)
  豊田実、今井浩三、篠村恭久, 中村眞一. (編集)
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-17109008
[Book] 造血器腫瘍アトラス改定第4版2007
- Author(s)
  豊田実他
- Publisher
  日本医事新報社出版局
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390221
[Book] Recent Advances in Gastrointestinal Carcinogenesis2006
- Author(s)
  Toyota M, et al.
- Total Pages
  247
- Publisher
  Transworld Research Network
- Data Source
  KAKENHI-PROJECT-18390221
[Book] 別冊医学のあゆみ酸化ストレスVer.22006
- Author(s)
  豊田実他
- Total Pages
  466
- Publisher
  医歯薬出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390221
[Book] The role and clinical implication of DNA methylation in gastrointestinal cancer.(Edited by Bamba H and Ota S, Recent Advances in Gastrointestinal Carcinogenesis.)2006
- Author(s)
  Toyota M, Suzuki H, Maruyama R, Tarasawa I, Yamamoto E, Tokino T, Imai K, Shinomura Y.
- Publisher
  Transworld Research Network, Kerala
- Data Source
  KAKENHI-PROJECT-17013073
[Book] Recent Advances in Gastrointestinal Carcinogenesis2006
- Author(s)
  Toyota M et al.
- Total Pages
  247
- Publisher
  Transworld Research Network
- Data Source
  KAKENHI-PROJECT-17013073
[Book] Recent Advances in Gastrointestinal Carcinogenesis2006
- Author(s)
  Toyota M et al.
- Total Pages
  247
- Publisher
  Transworld Research Network
- Data Source
  KAKENHI-PROJECT-17390221
[Book] The role and clinical implication of DNA methylation in gastrointestinal cancer. Recent Advances in Gastrointestinal Carcinogenesis.2006
- Author(s)
  Toyota M, Suzuki H, Maruyama R, Tarasawa I, Yamamoto E, Tokino T, Imai K, Shinomura Y
- Publisher
  Edited by Bamba H and Ota S, Transworld Research Network, Kerala, India
- Data Source
  KAKENHI-PROJECT-17109008
[Book] Recent Advances in Gastrointestinal Carcinogenesis2006
- Author(s)
  Toyota M et al.
- Total Pages
  247
- Publisher
  Transworld Research Network
- Data Source
  KAKENHI-PROJECT-17109008
[Book] The role and clinical implication of DNA methylation in gastrointestinal cancer.Recent Advances in Gastrointestinal Carcinogenesis2006
- Author(s)
  Toyota, et. al.
- Total Pages
  247
- Publisher
  Transworld Research Network
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390221
[Book] わかる実験医学・エピジェネティクスがわかる.2004
- Author(s)
  豊田実他
- Publisher
  羊土社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] IGFBP7 is p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
- Author(s)
  Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JPJ, Shinomura Y, Tokino T, Toyota M.
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 342-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Epigenetic driver of genetic alterations.2010
- Author(s)
  Toyota M
- Journal Title
  
  Advances Genetics
  
  Volume: 70 Pages: 309-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300320
[Journal Article] IGFBP7 is p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
- Author(s)
  Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JPJ, Shinomura Y, Tokino T, Toyota M
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 342-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma.2009
- Author(s)
  Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
- Journal Title
  
  Clin Cancer Res 15
  
  Pages: 4356-4364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Integrated analysis of genetic and epigenetic alterations in cancer.2009
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Epigenomics 1
  
  Pages: 291-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Inflammation-related aberrant patterns of DNA methylation : detection and role in epigenetic deregulation of cancer cell transcriptome2009
- Author(s)
  Suzuki H, Toyota M, Kondo Y, Shinomura Y.
- Journal Title
  
  Methods Mol Biol 512
  
  Pages: 55-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Integrated analysis of genetic and epigenetic alterations in cancer2009
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Epigenomics 1
  
  Pages: 291-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] The Epigenome of colorectal cancer.2009
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Curr. Colorectal Cancer Rep. 5
  
  Pages: 84-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] The Epigenome of colorectal cancer2009
- Author(s)
  Toyota M, Suzuki H, Shinomura Y.
- Journal Title
  
  Current Colorectal Cancer Reports 5
  
  Pages: 84-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] a potent tumor suppressor2009
- Author(s)
  Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y,, Tokino T. CHFR
- Journal Title
  
  downregulates interleukin-8 via inhibition of NF-κB. Oncogene 28
  
  Pages: 2643-2653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy.2009
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy2009
- Author(s)
  Toyota M., et.al.
- Journal Title
  
  Cancer Sci 100
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] p53 family members regulate the expression of the apolipoprotein D gene2009
- Author(s)
  Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 872-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Overexpression of Aurora a by loss of CHFR gene expresion increases the growth of HTLV-1-infected T cells through enhanced NF-kB activity.2009
- Author(s)
  Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara J, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
- Journal Title
  
  Int J Cancer 124
  
  Pages: 2607-2615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Integrated analysis of genetic and epigenetic alterations in cancer.2009
- Author(s)
  Toyota M, Suzuki H, Yamamoto E, Yamano H, Imai K, Shinomura Y
- Journal Title
  
  Epigenomics 1
  
  Pages: 291-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] CHFR, a potent tumor suppressor, downregulates interleukin-8 via inhibition of NF-・B2009
- Author(s)
  Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, , Tokino T.
- Journal Title
  
  Oncogene (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma2009
- Author(s)
  Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y.
- Journal Title
  
  Clin Cancer Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Sensitive and specific detection of early gastric cancer using DNA methylation analysis of gastric washing.2009
- Author(s)
  Watanabe, Y, Kim, HS, Castoro, RJ, Chyng, W, Estecio, MR, Kondo, K, Guo, Y, Ahmed, SS, Toyota, M, Itoh, F, Suk, KT, Cho, MY, Shen, L, Jelinek, J, Issa, JP.
- Journal Title
  
  Gastroenterol 136
  
  Pages: 2149-2158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] The epigenome of colorectal cancer2009
- Author(s)
  Toyota M., et.al.
- Journal Title
  
  Curr. Colorectal Cancer Rep 5
  
  Pages: 84-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Cancer Epigenomics: Implications of DNA methylation in personalized therapy.2009
- Author(s)
  Toyota M, Suzuki H, Yamashita T, Hirata K, Shinomura Y, Tokino T, Imai K
- Journal Title
  
  Cancer Sci 100
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma.2009
- Author(s)
  Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
- Journal Title
  
  Clin Cancer Res 15
  
  Pages: 4356-4364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy.2009
- Author(s)
  Toyota M, Suzuki H, Yamashita T, Hirata K, Shinomura Y, Tokino T, Imai K
- Journal Title
  
  Cancer Sci 100
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy2009
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] The Epigenome of colorectal cancer.2009
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Curr.Colorectal Cancer Rep. 5
  
  Pages: 84-89
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Sensitive and specific detection of early gastric cancer using DNA methylation analysis of gastric washing2009
- Author(s)
  Watanabe, Y, Kim, HS, Castoro, RJ, Chyng, W, Estecio, MR, Kondo, K, Guo, Y, Ahmed, SS, Toyota, M, Itoh, F, Suk, KT, Cho, MY, Shen, L, Jelinek, J and Issa, JP.
- Journal Title
  
  Gastroenterol, Published on line
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy.2009
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Overexpression of Aurora a by loss of CHFR gene expresion increases the growth of HTLV-1-infected T cells through enhanced NF-kB activity2009
- Author(s)
  Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara J, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N.
- Journal Title
  
  Int J Cancer 124
  
  Pages: 2607-2615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Elevated Dnmt3a activity promotes polyposis in ApcMin mice by relaxing extracellular restrains on Wnt signaling.2009
- Author(s)
  Samuel MS, Suzuki H, Buchert M, Putoczki TL, Tebbutt NC, Lundgren-May T, Christou A, Inglese M, Toyota M, Heath JK, Ward RL, Waring PM, Ernst M
- Journal Title
  
  Gastroenterol 137
  
  Pages: 902-913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Characteristic epigenetic profiles of malignant pleural mesothelioma.2009
- Author(s)
  Goto Y, Shinjo K, Kondo Y, Shen L, Toyota M, Suzuki H, Gao Y, An B, Fujii M, Murakami H, Osada H, Taniguchi T, Usami N, Kondo M, Hasegawa Y, Shimokata K, Matsuo K, Hida T, Fujimoto N, Kishimoto T, Issa JP, Sekido Y
- Journal Title
  
  Cancer Res 69
  
  Pages: 9073-9082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy2009
- Author(s)
  Toyota M, Suzuki H, Yamashita T, Hirata K, Shinomura Y, Tokino T, Imai K.
- Journal Title
  
  Cancer Sci 100
  
  Pages: 787-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009
- Author(s)
  Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  J Biol Chem 284
  
  Pages: 872-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer2008
- Author(s)
  Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T.
- Journal Title
  
  British J Cancer 98
  
  Pages: 1147-1156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka Y, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Carcinogenesis 29
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008
- Author(s)
  Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
- Journal Title
  
  J. Gastroenterol 43
  
  Pages: 378-389
- NAID
  10021268741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008
- Author(s)
  Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
- Journal Title
  
  Pharmacogenomics 9
  
  Pages: 1917-1928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma2008
- Author(s)
  Sogabe Y, Suzuki H, Toyota M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T.
- Journal Title
  
  Int J Oncol 32
  
  Pages: 1253-1261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] A requirement for DICER to maintain full promoter CpG Island hypermethylation in human cancer cells.2008
- Author(s)
  Ting A, Suzuki H, Cope L, Schuebel K, Lee B, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
- Journal Title
  
  Cancer Res 68
  
  Pages: 2570-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008
- Author(s)
  Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
- Journal Title
  
  Cancer Sci 99
  
  Pages: 958-966
- NAID
  10024006089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Identification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members2008
- Author(s)
  Sasaki Y, Ohshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T.
- Journal Title
  
  Mol Cancer Res 6
  
  Pages: 395-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer2008
- Author(s)
  Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T.
- Journal Title
  
  Cancer Res 68
  
  Pages: 4123-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] The hsitone deacetylase inhibitor FK288 enhances adenovirus-mediated p53 family gene therapy in cancer models2008
- Author(s)
  Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T.
- Journal Title
  
  Mol Cancer Ther 7
  
  Pages: 779-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Identification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members.2008
- Author(s)
  Sasaki Y, Ohshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Mol Cancer Res 6
  
  Pages: 395-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] A requirement for DICER to maintain full promoter CpG Island hypermethylation in human cancer cells2008
- Author(s)
  Ting A, Suzuki H, Cope L, Schuebel K, Lee B, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB.
- Journal Title
  
  Cancer Res 68
  
  Pages: 2570-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] dentification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members.2008
- Author(s)
  Sasaki Y, Ohshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  ol Cancer Res 6
  
  Pages: 395-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Imai K, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y.
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] A requirement for DICER to maintain full promoter CpG Island hypermethylation in human cancer cells.2008
- Author(s)
  Ting A, Suzuki H, Cope L, Schuebel K, Lee B, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
- Journal Title
  
  Cancer Res 68
  
  Pages: 2570-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] DNA hypermethylation contributes incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.2008
- Author(s)
  Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
- Journal Title
  
  Gastroenterol 135
  
  Pages: 142-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors2008
- Author(s)
  Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M.
- Journal Title
  
  Pharmacogenomics 9
  
  Pages: 1917-1928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Cancer Res. 68
  
  Pages: 4123-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M, et. al.
- Journal Title
  
  Cancer Res. 68(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390221
[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka Y, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Carcinogenesis 29
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Res 68
  
  Pages: 4123-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M., et al.
- Journal Title
  
  Cancer Res. 68
  
  Pages: 4123-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] The hsitone deacetylase inhibitor FK288 enhances adenovirus-mediated p53 family gene therapy in cancer models.2008
- Author(s)
  Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Mol Cancer Ther 7
  
  Pages: 779-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer2008
- Author(s)
  Toyota M., et.al.
- Journal Title
  
  Cancer Res 68
  
  Pages: 4123-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008
- Author(s)
  Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
- Journal Title
  
  British J Cancer 98
  
  Pages: 1147-1156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] DNA hypermethylation contributes incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.2008
- Author(s)
  Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
- Journal Title
  
  Gastroenterol 135
  
  Pages: 142-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008
- Author(s)
  Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
- Journal Title
  
  Pharmacogenomics 9
  
  Pages: 1917-1928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma2008
- Author(s)
  Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y.
- Journal Title
  
  J. Gastroenterol 43
  
  Pages: 378-389
- NAID
  10021268741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] DNA hypermethylation contributes incomplete synthesis of carbohydrate determinants in gastrointestinal cancer2008
- Author(s)
  Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T.
- Journal Title
  
  Gastroenterol 135
  
  Pages: 142-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka Y, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T.
- Journal Title
  
  Carcinogenesis 29
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] The hsitone deacetylase inhibitor FK288 enhances adenovirus- mediated p53 family gene therapy in cancer models.2008
- Author(s)
  Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Mol Cancer Ther 7
  
  Pages: 779-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Imai K, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev 2555-2564
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Res 68
  
  Pages: 4123-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma2008
- Author(s)
  Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T.
- Journal Title
  
  Cancer Sci 99
  
  Pages: 958-966
- NAID
  10024006089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Imai K, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007
- Author(s)
  Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Itoh F, Tokino T
- Journal Title
  
  Clin Cancer Res 13
  
  Pages: 4786-4794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Antitumor effect of adenoviras-mediated p53 family gene transfer on osteosarcoma cell lines2007
- Author(s)
  Ohshima Y, Sasaki Y, Negishi H, Idogawa M, Toyota M, Yamashita T, Wada T, Nagoya S, Kawaguchi S, Yamashita T, Tokino T.
- Journal Title
  
  Cancer Biol Ther 6
  
  Pages: 1058-1066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Comparing the DNA hypermethylation with gene mutations in human colorectal cancer2007
- Author(s)
  Schuebel KE, Chen E, Cope Lm Glockner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB.
- Journal Title
  
  Plos Genet 3
  
  Pages: 1709-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
- Author(s)
  Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Sci 98
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors2007
- Author(s)
  Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y.
- Journal Title
  
  Carcinogenesis 28
  
  Pages: 2459-2466
- NAID
  130004436413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Integrated genetic and epigenetic analysis identifies colon cancer corresponding to three different subclasses of disease.2007
- Author(s)
  Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, Hernandez N, Chen X, Ahmed S, Konishi K, Hamilton SR, Issa JPJ
- Journal Title
  
  Proc Natl Acad Sci U S A 104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Gene amplification and overexpression of PRDM14 in breast cancer2007
- Author(s)
  Nishikawa N, Toyota M, Suzuki H, Homma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
- Journal Title
  
  Cancer Res 67
  
  Pages: 9649-9657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer2007
- Author(s)
  Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Itoh F, Tokino T.
- Journal Title
  
  Clin Cancer Res 13
  
  Pages: 4786-4794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Gene amplification and overexpression of PRDM14 in breast cancer2007
- Author(s)
  Nishikawa N, Toyota M, Suzuki H, Homma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
- Journal Title
  
  Cancer Res 67
  
  Pages: 9649-9657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Antitumor effect of adenoviras-mediated p53 family gene transfer on osteosarcoma cell lines.2007
- Author(s)
  Ohshima Y, Sasaki Y, Negishi H, Idogawa M, Toyota M, Yamashita T, Wada T, Nagoya S, Kawaguchi S, Yamashita T, Tokino T
- Journal Title
  
  ncer Biol Ther 6
  
  Pages: 1058-1066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
- Author(s)
  Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Sci 98
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Comparing the DNA hypermethylation with gene mutations in human colorectal cancer.2007
- Author(s)
  Schuebel KE, Chen E, Cope Lm Glockner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engel, M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB
- Journal Title
  
  Plos Genet 3
  
  Pages: 1709-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Integrated genetic and epigenetic analysis identifies colon cancer corresponding to three different subclasses of disease2007
- Author(s)
  Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, Hernandez N, Chen X, Ahmed S, Konishi K, Hamilton SR, Issa JPJ.
- Journal Title
  
  Proc Natl Acad Sci U S A 104
  
  Pages: 18654-18659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007
- Author(s)
  Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
- Journal Title
  
  Oncogene 26
  
  Pages: 4699-4713
- NAID
  130004927598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer2007
- Author(s)
  Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y.
- Journal Title
  
  Oncogene 26
  
  Pages: 4699-4713
- NAID
  130004927598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer2007
- Author(s)
  Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T.
- Journal Title
  
  Cancer Sci 98
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007
- Author(s)
  Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
- Journal Title
  
  Oncogene 26
  
  Pages: 4699-4713
- NAID
  130004927598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Comparing the DNA hypermethylation with gene mutations in human colorectal cancer.2007
- Author(s)
  Schuebel KE, Chen E, Cope Lm Glockner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB
- Journal Title
  
  Plos Genet 3
  
  Pages: 1709-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007
- Author(s)
  Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Carcinogenesis 28
  
  Pages: 2459-2466
- NAID
  130004436413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Gene amplification and overexpression of PRDM14 in breast cancer2007
- Author(s)
  Nishikawa N, Toyota M, Suzuki H, Homma. T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T.
- Journal Title
  
  Cancer Res 67
  
  Pages: 9649-9657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390201
[Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007
- Author(s)
  Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Itoh F, Tokino T
- Journal Title
  
  Clin Cancer Res 13
  
  Pages: 4786-4794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007
- Author(s)
  Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Carcinogenesis 28
  
  Pages: 2459-2466
- NAID
  130004436413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] HOXB13 is epigenetically inactivated in human renal cell carcinoma and may be a tumor suppressor gene.2006
- Author(s)
  Okuda H, Toyota M, Ishida W, Furihata M, Tsuchiya M, Kamada T, Tokino T, Shuin T
- Journal Title
  
  Oncogene 25
  
  Pages: 1733-1742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus.2006
- Author(s)
  Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Cancer 106
  
  Pages: 1467-1479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Comparative genome analysis identified the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006
- Author(s)
  aruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Res 66
  
  Pages: 4574-4583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus.2006
- Author(s)
  Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Cancer 106
  
  Pages: 1467-1479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Comparative genome analysis identified the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006
- Author(s)
  Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Res 66
  
  Pages: 4574-4583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] The Ras effector RASS2 is a novel tumor suppressor gene in human colorectal cancer.2005
- Author(s)
  Akino K, Toyota M et al.
- Journal Title
  
  Gastroenterology 128(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.2005
- Author(s)
  Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K
- Journal Title
  
  J Gastroenterol 40
  
  Pages: 504-510
- NAID
  10015648191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005
- Author(s)
  Murai M, Toyota M, Suzuki H, Satoh A, Akino K, Mita H, Tokino T, Imai K
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 1021-1027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Haploinsufficiency in multiploid colorectal cancer.2005
- Author(s)
  Toyota M. et al.
- Journal Title
  
  J.Gastroenterol. 40・7
  
  Pages: 771-772
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] The Ras Effector RASS2 is a novel tumor suppressor gene in human colorectal cancer.2005
- Author(s)
  Akino K, Toyota M et al.
- Journal Title
  
  Gastroenterology 128(In press)
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic changes in solid and hematopoietic tumors.2005
- Author(s)
  Toyota M. et al.
- Journal Title
  
  Semm.Oncol. 32・5
  
  Pages: 521-530
- Data Source
  KAKENHI-PROJECT-17390221
[Journal Article] The RAS effector RASSF2 is a novel tumor suppressor in colorectal cancer.2005
- Author(s)
  Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa JP, Hinoda Y, Imai K, Tokino T
- Journal Title
  
  Gastroenterol 129
  
  Pages: 156-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] he RAS effector RASSF2 is a novel tumor suppressor in colorectal cancer.2005
- Author(s)
  Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa JP, Hinoda Y, Imai K, Tokino T
- Journal Title
  
  Gastroenterol 129
  
  Pages: 156-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Epigenetic changes in solid and hematopoietic tumors.2005
- Author(s)
  Toyota M, Issa JP
- Journal Title
  
  Semm Oncol 32 (5)
  
  Pages: 521-530
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390221
[Journal Article] Epigenetic changes in solid and hematopoietic tumors.2005
- Author(s)
  Toyota M, Issa JP
- Journal Title
  
  Semm Oncol 32・5
  
  Pages: 521-530
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390221
[Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005
- Author(s)
  Murai M, Toyota M et al.
- Journal Title
  
  Clin Cancer Res. 11
  
  Pages: 1021-1027
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] Haploinsufficiency in multiploid colorectal cancer.2005
- Author(s)
  Toyota M. et al.
- Journal Title
  
  J.Gastroenterol. 40・7
  
  Pages: 771-772
- Data Source
  KAKENHI-PROJECT-17390221
[Journal Article] Epigenetic changes in solid and hematopoietic tumors.2005
- Author(s)
  Toyota M, Issa JP
- Journal Title
  
  Semin. Oncol. 32
  
  Pages: 521-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005
- Author(s)
  Murai M, Toyota M et al.
- Journal Title
  
  Clin Cancer Res. 11
  
  Pages: 1021-1027
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] The Ras Effector RASS2 is a novel tumor suppressor gene in human colorectal cancer.2005
- Author(s)
  Akino K, Toyota M et al.
- Journal Title
  
  Gastroenterology 128(In press)
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] The Ras Effector RASS2 is a novel tumor suppressor gene in human colorectal cancer.2005
- Author(s)
  Akino K, Toyota M et al.
- Journal Title
  
  Gastroenterology 128(In press)
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005
- Author(s)
  Murai M, Toyota M et al.
- Journal Title
  
  Clin Cancer Res. 11
  
  Pages: 1021-1027
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005
- Author(s)
  Murai M, Toyota M, Suzuki H, Satoh A, Akino K, Mita H, Tokino T, Imai K
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 1021-1027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Aberrant methylation and silencing of the BNIP3 gene in hematopietic tumors.2005
- Author(s)
  Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Ishida T, Tokino T, Imai K
- Journal Title
  
  British J Cancer 92
  
  Pages: 1165-1172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Epigenetic changes in solid and hematopoietic tumors.2005
- Author(s)
  Toyota M. et al.
- Journal Title
  
  Semm.Oncol. 32・5
  
  Pages: 521-530
- Data Source
  KAKENHI-PROJECT-17013073
[Journal Article] Epigenetic inactivation of TMS1/ASC in ovarian cancer.2004
- Author(s)
  Terasawa K, Toyota M et al.
- Journal Title
  
  Clin Cancer Res. 10
  
  Pages: 2000-2006
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Epigenetic inactivation of class II transactivator (CIITA) is associated with absence of interferon-γ induced HLA-DR expression in colorectal and gastric cancer cells.2004
- Author(s)
  Satoh A, Toyota M et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 8876-8886
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Epigenetic inactivation of SFRP's complements genetic alterations to allow constitutive Wnt pathway signaling in human colorectal cancer.2004
- Author(s)
  Suzuki H, Toyota M et al.
- Journal Title
  
  Nat.Genet. 36
  
  Pages: 417-422
- NAID
  130004436353
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Identification of SCN3B as a novel p53-inducible proapoptotic gene.2004
- Author(s)
  Adachi K, Toyota M et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 7791-7798
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Epigenetic inactivation of SFRP's complements genetic alterations to allow constitutive Wnt pathway signaling in human colorectal cancer.2004
- Author(s)
  Suzuki H, Toyota M, Imai K et al.
- Journal Title
  
  Nat.Genet. 36
  
  Pages: 417-422
- NAID
  130004436353
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] Epigenetic inactivation of TMS1/ASC in ovarian cancer2004
- Author(s)
  Terasawa K, Toyota M et al.
- Journal Title
  
  Clin Cancer Res 10
  
  Pages: 2000-2006
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of TMS1/ASC in ovarian cancer.2004
- Author(s)
  Terasawa K, Toyota M et al.
- Journal Title
  
  Clin Cancer Res. 10
  
  Pages: 2000-2006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of class II transactivator (CIITA) is associated with absence of interferon-γ induced HLA-DR expression in colorectal and gastric cancer cells.2004
- Author(s)
  Satoh A, Toyota M, Imai K et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 8876-8886
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] Epigenetic inactivation of SFRP's complements genetic alterations to allow constitutive Wnt pathway signaling in human colorectal cancer2004
- Author(s)
  Suzuki H, Toyota M et al.
- Journal Title
  
  Nat. Genet. 36
  
  Pages: 417-422
- NAID
  130004436353
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of class II transactivator (CIITA) is associated with absence of interferon-y induced HLA-DR expression in colorectal and gastric cancer cells2004
- Author(s)
  Satoh A, Toyota M et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 8876-8886
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Identification of SCN3B as a novel p53-inducible proapoptotic gene.2004
- Author(s)
  Adachi K, Toyota M et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 7791-7798
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of SFRP's complements genetic alterations to allow constitutive Wnt pathway signaling in human colorectal cancer.2004
- Author(s)
  Suzuki H, Toyota M et al.
- Journal Title
  
  Nat.Genet. 36
  
  Pages: 417-422
- NAID
  130004436353
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Epigenetic inactivation of class II transactivator (CIITA) is associated with absence of interferon-γ induced HLA-DR expression in colorectal and gastric cancer cells.2004
- Author(s)
  Satoh A, Toyota M et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 8876-8886
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of CHFR in human tumors.2003
- Author(s)
  Toyota M. et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 100
  
  Pages: 7818-7823
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Epigenetic inactivation of CHFR in human tumors2003
- Author(s)
  Toyota et al.
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 7818-7823
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of CHFR in human tumors.2003
- Author(s)
  Toyota M et al.
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 7818-7823
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.2003
- Author(s)
  Satoh A., Toyota M.et al.
- Journal Title
  
  Cancer Res. 63
  
  Pages: 8606-8613
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Epigenetic inactivation of CHFR in human tumors.2003
- Author(s)
  Toyota et al.
- Journal Title
  
  Proc Natl Acad Sci USA. 100
  
  Pages: 7818-7823
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer2003
- Author(s)
  Satoh A, Toyota M et al.
- Journal Title
  
  Cancer Res 63
  
  Pages: 8606-8613
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of CHFR in human tumors.2003
- Author(s)
  Toyota M et al.
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 7818-7823
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer2003
- Author(s)
  Obata T, Toyota M et al.
- Journal Title
  
  Clin Cancer Res 9
  
  Pages: 6410-6418
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.2003
- Author(s)
  Satoh A, Toyota M et al.
- Journal Title
  
  Cancer Res. 63
  
  Pages: 8606-8613
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.2003
- Author(s)
  Obata T, Toyota M et al.
- Journal Title
  
  Clin Cancer Res. 9
  
  Pages: 6410-6418
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390234
[Journal Article] Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia.2003
- Author(s)
  Shen L., Toyota M.et al.
- Journal Title
  
  Blood 101
  
  Pages: 1413-1416
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] DNA methylation and environmental exposures in human hepatocellular carcinoma.2002
- Author(s)
  Shen L., Toyota M.et al.
- Journal Title
  
  J.Natl.Cancer Inst. 94
  
  Pages: 755-761
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13214090
[Journal Article] Epigenetic inactivation of interferon regulatory factor genes in gastric cancer.
- Author(s)
  Yamashita M, Toyota M, Suzuki H, Nojima M, Yamamoto E, Kamimae S, Watanabe Y, Kai M, Akashi H, Maruyama R, Sasaki Y, Yamano H, Sugai T, Shinomura Y, Imai K, Tokino T, Itoh F
- Journal Title
  
  Cancer Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Patent] Method for detection of diseases using colonic mucosa.2010
- Inventor(s)
  豊田実, 山本英一郎, 神前正幸, 鈴木拓, 山野泰穂
- Industrial Property Rights Holder
  札幌医科大学
- Filing Date
  2010-08-30
- Overseas
- Data Source
  KAKENHI-PROJECT-22300320
[Patent] 新規遺伝子ACMG1のメチル化を指標とする胃癌の診断方法2009
- Inventor(s)
  豊田実、今井浩三、株式会社ジェネティックラボ
- Industrial Property Rights Holder
  豊田実、株式会社ジェネティックラボ
- Acquisition Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-17109008
[Patent] 新規遺伝子ACMG1のメチル化を指標とする胃癌の診断方法2009
- Inventor(s)
  豊田実、株式会社ジェネティックラボ
- Industrial Property Rights Holder
  豊田実、株式会社ジェネティックラボ
- Acquisition Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-17013073
[Patent] Method for detection of diseases using colonicmucosa2009
- Inventor(s)
  豊田実
- Industrial Property Rights Holder
  札幌医科大学
- Filing Date
  2009-08-28
- Overseas
- Data Source
  KAKENHI-PROJECT-17013073
[Patent] Method for detection of diseases using colonic mucosa2009
- Inventor(s)
  豊田実, 今井浩三
- Industrial Property Rights Holder
  札幌医科大学
- Filing Date
  2009-08-28
- Overseas
- Data Source
  KAKENHI-PROJECT-17109008
[Patent] 癌の検出方法および検出用キット、ならびに癌治療剤2008
- Inventor(s)
  豊田実、他4名
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2008-121671
- Filing Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-17013073
[Patent] 癌の検出方法および検出用キット、ならびに癌治療剤.2008
- Inventor(s)
  豊田実, 他4名
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2008-121671
- Filing Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-19390201
[Patent] 癌の検出方法および検出用キット、ならびに癌治療剤2008
- Inventor(s)
  豊田実
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2008-121671
- Filing Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-17013073
[Patent] 癌の検出方法および検出用キット、ならびに癌治療剤.2008
- Inventor(s)
  鈴木拓, 豊田実, 今井浩三, 他2名
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2008-121671
- Filing Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-17109008
[Patent] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006
- Inventor(s)
  豊田実
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2006-134878
- Acquisition Date
  2006-05-12
- Data Source
  KAKENHI-PROJECT-17013073
[Patent] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006
- Inventor(s)
  豊田実, 篠村恭久, 他
- Industrial Property Rights Holder
  北海道聖マリアンヌ医科大学
- Industrial Property Number
  2006-134878
- Filing Date
  2006-05-15
- Data Source
  KAKENHI-PROJECT-18390221
[Patent] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006
- Inventor(s)
  今井浩三, 豊田実他
- Industrial Property Rights Holder
  北海道聖マリアンナ医科大学
- Industrial Property Number
  2006-134878
- Filing Date
  2006-05-15
- Data Source
  KAKENHI-PROJECT-17109008
[Patent] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006
- Inventor(s)
  豊田実他
- Industrial Property Rights Holder
  北海道聖マリアンナ医科大学
- Industrial Property Number
  2006-134878
- Filing Date
  2006-05-15
- Data Source
  KAKENHI-PROJECT-17390221
[Patent] 胃粘膜洗浄・液を利用した疾患関連マーカー2006
- Inventor(s)
  豊田実, 他
- Industrial Property Rights Holder
  札幌医科大学
- Filing Date
  2006-05-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390221
[Patent] 乳癌および卵巣癌の治療薬、検出方法ならびに検出用キット2006
- Inventor(s)
  豊田実
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2006-263232
- Acquisition Date
  2006-09-27
- Data Source
  KAKENHI-PROJECT-17013073
[Patent] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006
- Inventor(s)
  豊田実他
- Industrial Property Rights Holder
  北海道聖マリアンナ医科大学
- Industrial Property Number
  2006-134878
- Filing Date
  2006-05-15
- Data Source
  KAKENHI-PROJECT-17013073
[Patent] ACMG1のメチル化を指標とする胃癌の診断方法2005
- Inventor(s)
  豊田実
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2005-220779
- Filing Date
  2005-07-29
- Data Source
  KAKENHI-PROJECT-17390221
[Patent] 新規遺伝子ACMG1のメチル化を指標とする胃癌の診断方法.2005
- Inventor(s)
  豊田他6名
- Industrial Property Rights Holder
  北海道
- Industrial Property Number
  2005-220779
- Filing Date
  2005-07-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854016
[Patent] 新規遺伝子ACMG1のメチル化を指標とする胃癌の診断方法2005
- Inventor(s)
  豊田他6名
- Industrial Property Rights Holder
  北海道
- Industrial Property Number
  2005-220779
- Filing Date
  2005-07-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390221
[Patent] ACMG1のメチル化を指標とする胃癌の診断方法2005
- Inventor(s)
  豊田実
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2005-220779
- Filing Date
  2005-07-29
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Epigenomic analysis for small cell numbers of lamina propria T cells and macrophage/dendritic cell fraction in ulcerative colitis2012
- Author(s)
  大坪武史、遠藤高帆、豊田哲郎、大島健志朗、萩原輝記、河村裕、小西文雄、矢野秀朗、斉藤幸夫、服部正平、稲垣匡子、河村由紀、土肥多惠子
- Organizer
  日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590712
[Presentation] IL-6, a potential inducer of DNA hypermethylation and malignant-type glycosylation in ulcerative colitis2011
- Author(s)
  Kawamura YI、Toyota M、Hagiwara T、Suzuki H、Yamazaki M、Okada T、Kawamura YJ、Konishi F、Yano H、Saito Y、Dohi T
- Organizer
  米国消化器病週間
- Place of Presentation
  シカゴ
- Data Source
  KAKENHI-PROJECT-22590712
[Presentation] 消化管でみられる癌性糖鎖不全とエピゲノム異常ワークショップ2 癌のepigeneticsとmicroRNA2011
- Author(s)
  河村由紀、豊田実、橋本真一、萩原輝記、山崎元美、河村裕、小西文雄、斉藤幸夫、服部正平、土肥多惠子
- Organizer
  日本病態治療研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590712
[Presentation] Genome wide analysis of epigenetically silenced genes using next-generation sequencer.2010
- Author(s)
  Toyota M.
- Organizer
  8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association : Cancer Genomics, Epigenomics, and the Development of Novel Therapy.
- Place of Presentation
  Hawaii, USA
- Year and Date
  2010-02-07
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Cancer epigenome analysis by massive parallel sequencing.2010
- Author(s)
  Toyota M
- Organizer
  Fifth Asian Epigenomics Meeting.
- Place of Presentation
  Jeju, Korea(招待講演)
- Year and Date
  2010-06-20
- Data Source
  KAKENHI-PROJECT-22300320
[Presentation] Epigenetics as Cancer Biomarkers.2010
- Author(s)
  Toyota M
- Organizer
  38th Congress of the International Society for Oncology and BioMarkers.
- Place of Presentation
  Munich, Germany(招待講演)
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-22300320
[Presentation] Genome wide analysis of transcription start sites of epigenetically silenced genes using next-generation sequencer.2010
- Author(s)
  Toyota M.
- Organizer
  An AACR Special Conference on Cancer Epigenetics.
- Place of Presentation
  San Juan, Puerto Rico
- Year and Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] IL-6 induces expression of DNA methyltransferases, gene silencing, and malignant-type glycosylation in ulcerative colitis and colitic cancer2010
- Author(s)
  Kawamura YI、Toyota M、Kawashima R、Okada T、Hagiwara T、Kawamura YJ、Konishi F、Matsumoto T、Dohi T
- Organizer
  米国消化器病週間
- Place of Presentation
  ニューオリンズ
- Data Source
  KAKENHI-PROJECT-22590712
[Presentation] IL-6誘導性DNA高メチル化がもたらす潰瘍性大腸炎およびcolitic cancerの糖鎖異常2010
- Author(s)
  河村由紀、豊田実、川島麗、萩原輝記、河村裕、小西文雄、斉藤幸夫、松本誉之、神奈木玲児、今井浩三、土肥多惠子
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590712
[Presentation] IL-6はDNAメチル基転移酵素の異所性発現を介して潰瘍性大腸炎における糖鎖異常を誘導する2010
- Author(s)
  河村由紀、豊田実、Vongsavanh Phongsisay、岡田俊彦、山崎元美、河村裕、小西文雄、斉藤幸夫、鈴木拓、神奈木玲児、松本誉之、今井浩三、土肥多惠子
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590712
[Presentation] The Origin of Colorectal Cancer with CpG Island Methylator Phenotype.2010
- Author(s)
  Toyota M
- Organizer
  41st International Symposium of The Princess Takamatsu Cancer Research Fund.
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-22300320
[Presentation] 新規エピゲノム法の開発と消化器癌発生の分子機構2009
- Author(s)
  豊田実、鈴木拓、山本英一郎、山野泰穂、篠村恭久
- Organizer
  第5回日本消化管学会総会、シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] 新規エピゲノム法の開発と消化器癌発生の分子機構.2009
- Author(s)
  豊田実, 他
- Organizer
  第5回日本消化管学会総会
- Place of Presentation
  東京
- Year and Date
  2009-02-12
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] The role of epigenetic changes in cancer immunothelapy2009
- Author(s)
  Toyota M, Imai K.
- Organizer
  US-Japan Workshop on Immunological Molecular Markers in Oncology
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Colorectal cancer epigenetics.2009
- Author(s)
  Toyota M
- Organizer
  37Th Meeting of International Society for Oncology and Biomarkers. Amsterdam
- Place of Presentation
  Netherlands
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Colorectal cancer epigenome and clinical implication.2009
- Author(s)
  Toyota M, Suzuki H, Yamamoto E, Kamimae S, Nijima M, Shinomura Y, Imai K
- Organizer
  First Guangzhou Symposium of Cancer Epigenetics and Kick-off Meeting of A3 Forsight Program and 973 Project
- Place of Presentation
  Guangzhou, China
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] CpG island methylator phenotype in colorectal cancer.2009
- Author(s)
  Toyota M.
- Organizer
  The 14th Korean-Japan Cancer Research Workshop.
- Place of Presentation
  Kanazawa, Japan
- Year and Date
  2009-12-19
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] The role of epigenetic changes in cancer immunothelapy.2009
- Author(s)
  Toyota M, Imai K
- Organizer
  US-Japan Workshop on Immunological Molecular Markers in Oncology
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Colorectal Cancer Epigenetics2009
- Author(s)
  Toyota M., Imai K.
- Organizer
  International Society for Oncology and Biomarkers 37^<Th> Meeting
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] 新規エピゲノム法の開発と消化器癌発生の分子機構2009
- Author(s)
  豊田実, 他
- Organizer
  第5回日本消化管学会総会
- Place of Presentation
  東京
- Year and Date
  2009-02-12
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] The role of epigenetic changes in cancer immunothelapy.2009
- Author(s)
  Toyota M, Imai K
- Organizer
  US-Japan Workshop on Immunological Molecular Markers in Oncology
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] がんにおいてDNAメチル化で不活化される新規遺伝子の同定2009
- Author(s)
  豊田実
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Colorectal cancer epigenome and clinical implication.2009
- Author(s)
  Toyota M.
- Organizer
  First Guangzhou Symposium of Cancer Epigenetics and Kick-off Meeting of A3 Forsighy Program and 973 Project
- Place of Presentation
  Guangzhou, China
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] 新規エピゲノム法の開発と消化器癌発生の分子機構.2009
- Author(s)
  豊田実, 他
- Organizer
  第5回日本消化管学会総会
- Place of Presentation
  東京
- Year and Date
  2009-02-12
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] CpG island methylator phenotype in colorectal cancer.2009
- Author(s)
  Toyota M
- Organizer
  The 14th Korean-Japan Cancer Research Workshop
- Place of Presentation
  Kanazawa
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Colorectal Cancer Epigenetics2009
- Author(s)
  Toyota M.
- Organizer
  International Society for Oncology and Biomarkers 37^<Th> Meeting
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Epigenetic gene silencing and micro RNA in human colon cancer.2008
- Author(s)
  Toyota M, et al.
- Organizer
  36th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] The role of DNA methylation changes in signaling pathway.2008
- Author(s)
  Toyota M, et al.
- Organizer
  AACR Special Conference on Cancer Research : Cancer Epigenetics
- Place of Presentation
  Boston, USA
- Year and Date
  2008-05-28
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Epigenetic gene silencing and microRNA in human colon cancer2008
- Author(s)
  Toyota M.
- Organizer
  Symposium, 36th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] The role of DNA methylation changes in signaling pathway2008
- Author(s)
  Toyota M
- Organizer
  AACR Special Conference on Cancer Research : Cancer Epigenetics
- Place of Presentation
  Boston, USA
- Year and Date
  2008-05-28
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] 大腸癌のシグナル経路異常におけるDNAメチル化の役割2008
- Author(s)
  豊田実, 他
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Epigenetic gene silencing and microRNA in human colon cancer. Symposium2008
- Author(s)
  Toyota M, Imai K
- Organizer
  36th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] The role of DNA methylation changes in signaling pathway.2008
- Author(s)
  Toyota M, et al.
- Organizer
  AACR Special Conference on Cancer Research : Cancer Epigenetics
- Place of Presentation
  Boston, USA
- Year and Date
  2008-05-28
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic gene silencing and microRNA in human colon cancer2008
- Author(s)
  Toyota M
- Organizer
  36th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] 大腸癌のシグナル経路異常におけるDNAメチル化の役割2008
- Author(s)
  豊田実, 他
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic gene silencing and microRNA in human colon cancer.2008
- Author(s)
  Toyota M, et al.
- Organizer
  36th Congress of the International Societyfor Oncodevelopmental Biology and Medicine
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] 大腸癌のシグナル経路異常におけるDNAメチル化の役割2008
- Author(s)
  豊田実, 他
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] The role of DNA methylation changes in signaling pathway.2008
- Author(s)
  Toyota M, Imai K
- Organizer
  AACR Special Conference on Cancer Research: Cancer Epigenetics
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] 大腸癌のシグナル経路異常におけるDNAメチル化の役割2008
- Author(s)
  豊田実、鈴木拓、篠村恭久、時野隆至、今井浩三
- Organizer
  第67回日本癌学会総会、シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] The role of DNA methylation changes in signaling pathway2008
- Author(s)
  Toyota M.
- Organizer
  AACR Special Conference on Cancer Research : Cancer Epigenetics
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] The role of DNA methylation changes in signaling pathway.2008
- Author(s)
  Toyota M, Imai K
- Organizer
  AACR Special Conference on Cancer Research: Cancer Epigenetics
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] 癌におけるエピジェネティックな異常の網羅的解析2008
- Author(s)
  豊田実、鈴木拓、篠村恭久、時野隆至
- Organizer
  第31回日本分子生物学会第81回日本生化学会合同年会、シンポジウム
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic gene silencing and microRNA in human colon cancer.2008
- Author(s)
  Toyota M, Imai K
- Organizer
  Symposium, 36th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] 慢性胃炎におけるエピジェネティックな異常-DNAメチル化のおこるプロセス-2007
- Author(s)
  豊田実
- Organizer
  第49回日本消化器病学会大会
- Place of Presentation
  神戸市
- Year and Date
  2007-10-21
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] The role of DNA methylation changes in signal transduction in gastric cancer2007
- Author(s)
  豊田実、鈴木拓、今井浩三、時野隆至、篠村恭久
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic silencing of genes involved in signaling pathway. Symposium2007
- Author(s)
  Toyota M, Suzuki H, Shinomura Y, Tokino T, Imai K
- Organizer
  The 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Epigenetic silencing of genes involved in signaling pathways in gastric cancer.2007
- Author(s)
  Toyota M
- Organizer
  35th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2007-09-18
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Frequent epigenetic inactivation of DICKKOPF family genes in gastrointestinal tumors.2007
- Author(s)
  Suzuki H, Toyota M, Maruyama R, Imai K, Shinomura Y
- Organizer
  35th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Plaque, Czech Republic
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Epigenetic silencing of genes involved in signaling pathway2007
- Author(s)
  Toyota, M, et. al.
- Organizer
  The 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Hawaii.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390221
[Presentation] The role of DNA methylation changes in signal transduction in gastric cancer.2007
- Author(s)
  豊田実
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜市
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] 慢性胃炎におけるエピジェネティックな異常-DNAメチル化のおこるプロセス-2007
- Author(s)
  豊田実
- Organizer
  第49回日本消化器病学会大会
- Place of Presentation
  神戸市
- Year and Date
  2007-10-21
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic alterations in gastrointestinal cancer: functional consequences and clinical application.2007
- Author(s)
  Toyota M
- Organizer
  IARC Cancer Epigenetics Meeting
- Place of Presentation
  Lyon, France
- Year and Date
  2007-12-06
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic silencing of genes involved in signaling pathways in gastric cancer.2007
- Author(s)
  Toyota M, et. al.
- Organizer
  35th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] 消化器癌におけるエピジェネティックな異常の解析と臨床応用2007
- Author(s)
  豊田実
- Organizer
  日本消化器病学会東海支部第107回例会・第18回教育講演会
- Place of Presentation
  名古屋
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic silencing of genes involved in signaling pathway2007
- Author(s)
  Toyota M, et. al.
- Organizer
  The 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Hawaii
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390221
[Presentation] Epigenetic alterations in gastrointestinal cancer:functional consequences and clinical application2007
- Author(s)
  Toyota M
- Organizer
  IARC Cancer Epigenetics Meeting
- Place of Presentation
  Lyon,France
- Year and Date
  2007-12-06
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Epigenetic silencing of genes involved in signaling pathways in gastric cancer. Symposium2007
- Author(s)
  Toyota M, Imai K
- Organizer
  5th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Plaque, Czech Republic
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Epigenetic silencing of genes involved in signaling pathways in gastric cancer2007
- Author(s)
  Toyota M.
- Organizer
  Symposium, 35th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Plaque, Czech Republic
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic silencing of genes involved in signaling pathway.2007
- Author(s)
  Toyota M, Suzuki H, Shinomura Y, Tokino T, Imai K
- Organizer
  Symposium, The 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
- Author(s)
  Toyota M, Suzuki H, Maruyama R, Akino K, Watanabe Y, Sasaki Y, Imai K, Tokino T, Shinomura Y
- Organizer
  98th Annual Meeting of American Association for Cancer Research.
- Place of Presentation
  Los Angeles
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
- Author(s)
  Toyota M, et. al.
- Organizer
  American Association for Cancer Research, Annual Meeting 2007
- Place of Presentation
  Los Angeles
- Data Source
  KAKENHI-PROJECT-18390221
[Presentation] The role of DNR methylation changes in signal transduction in gastric cancer2007
- Author(s)
  豊田実
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜市
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Epigenetic alterations in gastrointestinal cancer : functional consequences and clinical application2007
- Author(s)
  Toyota M.
- Organizer
  IARC Cancer Epigenetics Meeting
- Place of Presentation
  Lyon, France
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic silencing of genes involved in signaling pathways in gastric cancer2007
- Author(s)
  Toyota M
- Organizer
  35th Congress of the Iternational Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Prague,Czech Republic
- Year and Date
  2007-09-18
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] 慢性胃炎におけるエピジェネティックな異常-DNAメチル化のおこるプロセス-2007
- Author(s)
  豊田実、山本英一郎、篠村恭久
- Organizer
  第49回日本消化器病学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390201
[Presentation] Epigenetic inactivation of TCF2 in human tumors2006
- Author(s)
  Toyota M, Terasawa K, Sagae S, Ogi K, Suzuki H, Maruyama R, Shinomura Y, Saito T, Imai K, Tokino T
- Organizer
  97th Annual Meeting of American Association for Cancer Research
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-17109008
[Presentation] DNA methylation changes in cancer: application to diagnosis and therapy.2006
- Author(s)
  Toyota M, Suzuki H, Shinomura Y, Imai K
- Organizer
  Symposium, 34th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Pasadena, USA
- Data Source
  KAKENHI-PROJECT-17013073
[Presentation] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006
- Author(s)
  Toyota, et. al.
- Organizer
  American Association for Cancer Research, Annual Meeting
- Place of Presentation
  Washington DC
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390221
[Presentation] Epigenetic inactivation of TCF2 in human tumors2006
- Author(s)
  Toyota M, et. al.
- Organizer
  American Association for Cancer Research, Annual Meeting 2007
- Place of Presentation
  Washington DC
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390221
[Presentation] DNA methylation changes in cancer:application to diagnosis and therany2006
- Author(s)
  Toyota M, et. al.
- Organizer
  34 Congress of the International Society for Oncodevelonmental Biolosv and Medicine
- Place of Presentation
  Pasadena
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390221
[Presentation] DNA methylation changes in cancer: application to diagnosis and therapy. Symposium2006
- Author(s)
  Toyota M, Suzuki H, Shinomura Y, Imai K
- Organizer
  34th Congress of the International Society for Oncodevelopmental Biology and Medicine
- Place of Presentation
  Pasadena, USA
- Data Source
  KAKENHI-PROJECT-17109008

1. IMAI Kohzoh (60117603)

# of Collaborated Projects: 4 results

# of Collaborated Products: 43 results
2. YAMAMOTO Hiroyuki (40332910)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. SUZUKI Hiromu (20381254)

# of Collaborated Projects: 3 results

# of Collaborated Products: 58 results
4. ARIMURA Yoshiaki (80305218)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHINOMURA Yasuhisa (90162619)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
6. ENDO Takao (40191928)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KONDO Yutaka (00419897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NATSUME Atsushi (30362255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UESUGI Motonari (10402926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAWAMURA I. Yuki (10392391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. ITOH Fumio (90223180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 長尾美奈子 (40100151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 牛島俊和 (90232818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中釜斉 (30198030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 藤井美穂 (00260761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 寒河江悟 (00187056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 時野隆至 (40202197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 甲斐正広 (80260777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山本英一郎 (60567915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 野島正寛 (00457699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOYOTA Minoru 豊田 実

豊田 実 トヨタ ミノル

Research Projects

Research Products

Co-Researchers

転写後レベルでのエピジェネティックな遺伝子調節機構と発癌における役割Principal Investigator

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Epigenetic plasticity as a novel target for cancer treatment

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Epigenetically regulated tissue repair mechanism in gastrointestinal tract

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Development of a novel method for epigenome analysis and application to cancer diagnosis and order made therapyPrincipal Investigator

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Development of diagnostic methods of gastrointestinal cancer using integrated analysis of nuclear molecules

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Role of DNA methylation and altered histone modification in development and progression of cancerPrincipal Investigator

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Review Section

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Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy

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Tailor-made therapy of gastrointestinal cancer targeting aberrant modification of biological moleculesPrincipal Investigator

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卵巣癌におけるエピジェネティクスの異常の解析と治療への応用についての研究

Principal Investigator

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Development of a novel therapy for gastrointestinal cancer using epigenetic alterations as a target.Principal Investigator

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The mechanism of DNA methylation dependent gene silencing in gastrointestinal cancerPrincipal Investigator

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Aberrant methylation of inflammatory bowel disease and its application to risk assessment of cancerPrincipal Investigator

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Microsatellite instability and aberrant methylation in gastrointestinal cancer and its application to molecular target therapy

Principal Investigator

Project Period (FY)

TOYOTA Minoru 豊田実

豊田実トヨタミノル

[Book] 別冊医学のあゆみ酸化ストレスVer.22006