TAKAI Yoshimi 高井義美

Researcher Number	60093514
Other IDs
Affiliation *help	2015 – 2018 : 神戸大学, 医学研究科, 特命教授 2013 – 2015 : 神戸大学, 医学(系)研究科(研究院), 教授 2014 : 神戸大学, 大学院医学研究科, 教授 2012 : 神戸大学, 医学(系)研究科(研究院), 特命教授 2011 : 神戸大学, 医学(系)研究科(研究院), 教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Pathological medical chemistry / 物質生物化学 / General medical chemistry / 代謝生物化学 / Functional biochemistry Except Principal Investigator Biological Sciences / Digestive surgery / 成果取りまとめ / 物質生物化学 … More
Keywords	Principal Investigator GTP結合蛋白質 / Rho / Cキナーゼ / 細胞増殖因子 / Ras / 低分子量GTP結合蛋白質 / Rab3A / Rabphilin-3A / ras p21 / 細胞増殖 … More Except Principal Investigator GTP結合蛋白質 / 低分子量G蛋白質 / 神経伝達物質 / 低分子量GTP結合蛋白質 / イオンチャネル / Rabphilin-3A / Rab3A / 血管平滑筋 / 心筋症 / 心筋細胞 / 癌遺伝子 / イノシトールリン酸代謝 / がん / 心筋虚血 / Rho / シグナル伝達 / 細胞死 / がん遺伝子 / 共役機構 / 百日咳毒素 / アクティブゾーン / ADPリボシル化 / 癌 / サイクリックAMP / RabGDI / Ca^<2+> / 細胞内小胞輸送 / リポ蛋白 / ロイコトリエン / 血管内皮由来弛緩因子 / シナプトタグミン / 血管内皮 / エンドセリン / rabphilin / 遺伝子 / 酵母 / ADP-ribosylation / C2様領域 / リゾフォスファチジルコリン / Low molecular weight / calcium ion / 個人に最適ながん治療 / アラキドン酸 / コレステロール逆転送系 / 腫瘍血管 / ナトリウム利尿ペプチドファミリー / 嗅球 / 分子標的治療 / Secretion / GDP解離抑制因子 / プロテインキナーゼ / BDNF / smp p25A / カルシウム依存性プロテーゼ / 阻害剤 / mechanical stress / Yeast / スクリーニング / Gbetagamma subunit / 薬剤耐性 / 成果取り纏め / がん特性 / 細胞増殖因子 / がんゲノム / 遺伝子操作動物 / NDPキナーゼ / ウイルス / 細胞内情報伝達 / GDP-dissociation inhibitor / 膵外分泌腺細胞 / BNP / Small G Protein / Phosphorylation / ras蛋白質ファミリー / 受容性 / 蛋白質リン酸化反応 / Botulinum toxin / 細胞分化 / Research Materials / 医療・福祉 / 細胞組織 / 分泌 / がん研究の連携 / 増殖因子 / 低分子量GTP結合蛋白 / 膜容量変化 / G蛋白 / 情報伝達 / 細胞膜受容体 / アボトーシス / マクロファージ / signal transduction / がん診断・予防 / Small GTP-binding protein / リン酸化 / アンカリング蛋白質 / カルシウム濃度 / トランスメンブランコントロ-ル / regulated secretion / 再生 / 酸化LDL / Screening / 巨核球 / NGF / Growth factor / IRFファミリー / カルモジュリン遺伝子 / 研究支援・広報 / Ca調節 / Signal transduction / 研究資料 / ゲルゾリン / HDL / がん科学のニューフロンティア / Cancer Genome / 心肥大 / 細胞接着因子 / 細胞増殖 / Bile Acids / バイオサイエンス / ヒトがん / アクチビンA / VIP / endothelin / 細胞・組織 / ワ-トマニン / Molecular Target Therapy / 低分子量G蛋白 / 発がん制御 / 嗅神経細胞 / 哺乳類 / ral3A p25 / インシュリン / Cβγサブユニット / カルデスモン / cardiomyocytes / IGF / Membrane receptor / 走化性ペプチド / インターフェロン / 膵腺房細胞 / ナトリウム利尿ペプチドファミリ- / サイクリックGMP / Heterotrimeric G-protein / Small Molecular Weight G proteins / シナプス小胞 / 味細胞 / Support for Young Investigators / 大腸癌 / カルシウム依存性プロテアーゼ / ボツリヌス毒素 / ゲノム / chromaffin cells / リポ蛋白リパ-ゼ / ANP / membrane capacitance / アドレノメデュリン / 単離膵腺房細胞 / ゲルゾリンファミリー / キャッチ機構 / Pancreatic Acini / 収縮環 / カルパクチン / 細胞生物学 / 胆汁酸 / 細胞競合 / 若手支授 / がんの体系的理解 / SDMF / 視細胞 / PtdIns 3-kinase / GTP-binding protein / がん細胞 / 活性酸素生成 / rab3A p25 / 発がん抑制 / がん治療 / Small molecular GTP-binding protein / リポ蛋白リパーゼ / チロシンキナーゼ / ラッチ機構 / 受容体 / NO / アポトーシス / ホスホリパーゼC / 神経栄養因子 / 機能領域 / 細胞間相互作用 / GTP結分蛋白質 / 大腸粘膜上皮細胞 / Ca^<2+>センサー / Ras蛋白質ファミリー / イノシト-ル三リン酸 / VLDL受容体 / bFGF / PD-ECGF / カルモデュリンキナーゼII / Vesicle transport / Colon Carcinogenesis / p53 / ERMファミリー / エンドセリンファミリー / リポソーム / Cancer / nectin / 細胞接着 / 国際学術研究交流 / 心不全 / Ras protein family / RIFファミリー / シナプス / GDP解離促進因子 / NDPキナ-ゼ / pancreatic acinar cells / 若手支援 / 嗅神経 / PI-3-キナーゼ / 分化 / 平滑筋ミオシン / Wortmannin / 増殖 / Gβγサブユニット / CETP / 3量体G蛋白質 / Ca^<2+>チャネル / 研究資材 / smg p25a / G protein / 樹状細胞 / Gene Manipulated Animals / エンドセリンファミリ- / Protein tyrosine kinase / ウィルス / がん研究の推進 / トランスメンブランコントロール / 大腸発癌 / International Scientific Exchange / ムスカリン受容体 / 嗅細胞 / 分子薬理学 / 発がん / CNP / CD44 / カルシウム依存性ブロテアーゼ / Angiotensin II / 細胞質分裂 / 先端的研究 / ルテニウムレッド / M-CSF / アクチンフィラメント / 転移 / Mammalian / 嗅上皮 / 白血病 / トランスロケーション / adrenomedulin / Doc2 / がん転移 / GDP-dissociation stimulator / furaー2 / 胎児型ミオシン重鎖 / がん研究支援 / 低分子量 / アンジオテンシンII / VLDL容体 / 遺伝学 / リポコルチン Less

上皮細胞の競合に関与する細胞間接着分子の同定と作用機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  高井義美
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Roles and modes of action of nectins in heterotypic cell-cell adhesionsPrincipal Investigator
- Principal Investigator
  
  Takai Yoshimi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Cell competition: a mechanism for survival of the fittest in the multi-cellular communityOngoing
- Principal Investigator
  
  藤田恭之
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Comprehensive Study on Regeneration of Olfactory Epithelium and Bulb
- Principal Investigator
  
  KEN-ICH Nibu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kobe University
Roles of Cell Adhesion and Signaling in Cell MorphogenesisPrincipal Investigator
- Principal Investigator
  
  TAKAI YOSHIMI
- Project Period (FY)
  2009 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Role of cell adhesion signaling in the abnormal cell polarization of cancer cellsPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
  Osaka University
Integrative Research Toward the Conquest of Cancer
- Principal Investigator
  
  TANIGUCHI Tadatsgu
- Project Period (FY)
  2004 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Field
  
  成果取りまとめ
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Genetic and Epigenetic Dysregulation in Cancer
- Principal Investigator
  
  NODA Tetsuo
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
  Tohoku University
Disorganization of cell and tissue systems in cancerPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
  Osaka University
細胞増殖のシグナリング機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
がんの生物学的特性の研究の総括
- Principal Investigator
  
  SASAZUKI Takehiko, 黒木登志夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
  Showa University
  The University of Tokyo
がんの戦略的先端研究
- Principal Investigator
  
  渋谷正史, 吉田光昭
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
がんの生物学的特性に関する研究の総括Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1999 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
General Promotion of Cancer Research in Japan
- Principal Investigator
  
  TSURUO Tahashi
- Project Period (FY)
  1999 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tokyo
Modes of activation and action of Small G proteinsPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
C_2様領域を持つ新しい蛋白質Rabphilin-3AとDoc2の機能と作用機構
- Principal Investigator
  
  佐々木卓也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
シナプスにおける新しいCa^<2+>センサーの機能と作用機構
- Principal Investigator
  
  白瀧博通
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
神経伝達物質の放出機構におけるRab3A低分子量G蛋白質系の機能と作用機構
- Principal Investigator
  
  佐々木卓也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
プレ・ポストシナプスの相互作用における低分子量G蛋白質の役割と作用機構
- Principal Investigator
  
  SHIRATAKI Hiromichi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
心筋細胞の刺激受容機構とシグナル伝達系
- Principal Investigator
  
  矢崎義雄
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
細胞質分裂における低分子量G蛋白質Rhoの機能と作用機構
- Principal Investigator
  
  佐々木卓也
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
細胞の増殖・分化のシグナルの伝達機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
Signal transduction of Small GTP-binding proteinsPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
cDNAs and antibodies for small GTP-binding proteinsPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
細胞内情報伝達系と細胞増殖の制御機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
血管機能における神経・体液性因子の相関・病態
- Principal Investigator
  
  北徹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
蛋白質の選別輸送における低分子量GTP結合蛋白質の機能と作用機構
- Principal Investigator
  
  佐々木卓也
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
GTP-binding Proteins as Cellular Signal Transducer
- Principal Investigator
  
  UI Michio
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
  The Institute of Physical and Chemical Research
Action mechanisms and roles of small GTP-binding proteins
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
蛋白質の選別輸送における低分子量GTP結合蛋白質の機能と作用機構
- Principal Investigator
  
  佐々木卓也
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
神経伝達物質放出における低分子量GTP結合蛋白質の機能と作用機構
- Principal Investigator
  
  貝淵弘三
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
情報転換因子としてのGTP結合蛋白質
- Principal Investigator
  
  UI Michio
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  The University of Tokyo
動脈硬化症の分子生物学的解析と予防・抑制対策に関する総合的研究
- Principal Investigator
  
  北徹
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
細胞内情報伝達系と細胞増殖の制御機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
血管機能における神経・体液性因子の相関・病態
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Studies on the conformation and functions of ras-related low Mr GTP-binding proteins.
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu University
signal transduction of small GTP binding proteinsPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kode University
cDNAs and antibodies for small GTP-binding proteinsPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Kobe University
トランスメンブランコントロ-ルにおけるGTP結合蛋白質の役割
- Principal Investigator
  
  野村靖幸
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
バイオサイエンスの進展に基づくがんの重点研究
- Principal Investigator
  
  豊島久真男
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
細胞内情報伝達系と細胞増殖の制御機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
バイオサイエンスの進展に基づくがんの重点研究
- Principal Investigator
  
  豊島久真男
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
バイオサイエンスの進展に基づくがんの重点研究
- Principal Investigator
  
  豊島久真男
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
細胞増殖シグナル伝達の機構と癌遺伝子産物の作用Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
蛋白質リン酸化反応の生物学的意義に関する総合的研究
- Principal Investigator
  
  日高弘義
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Nagoya University
心筋細胞の損傷・修復過程とその修飾因子
- Principal Investigator
  
  河合忠一
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
トランスメンブランコントロールにおけるGTP結合蛋白質の役割
- Principal Investigator
  
  野村靖幸
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
細胞分化の制御におけるCキナ-ゼとrasp21類似GTP結合蛋白質の作用機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Physiological roles of low molecular weight 20KG GTP-binding protein : Effects on secretion in pancreatic acinar cells.
- Principal Investigator
  
  MARUYAMA Yoshio
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical School
Small GTP-Binding Proteins and Intracellular Messenger SystemsPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Kobe University
cDNAs and Antibodies for Small GTP-binding ProteinsPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
細胞の癌化におけるCキナーゼと癌遺伝子の相互作用Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
細胞増殖因子による細胞周期の制御機構におけるCキナーゼの役割Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
心筋細胞の損傷・修復過程とその修飾因子
- Principal Investigator
  
  河合忠一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
MECHANISM OF ACTION OF BILE ACIDS AS PROMOTER FOR COLON CARCINOGENESIS
- Principal Investigator
  
  OHYANAGI Harumasa
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KOBE UNIVERSITY
細胞の癌化におけるCキナーゼと癌遺伝子の相互作用Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
シナプスの可塑性におけるCキナーゼの役割Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kobe University
神経伝達物質によるイノシトールリン脂質代謝の抑制機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
心筋細胞の損傷・修復過程とその修飾因子
- Principal Investigator
  
  河合忠一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Phosphoinositide metabolism in transmembrane signallingPrincipal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Kobe University
細胞の癌化におけるCキナーゼと癌遺伝子の相互作用Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
受容分子からイオンチャネルへの情報伝達
- Principal Investigator
  
  栗原堅三
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Hokkaido University
神経活性物質受容体によるジグリセリド産生の制御機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kobe University
血管平滑筋細胞の細胞膜受容伝達機構を構成する蛋白質の同定とその機能の解析Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kobe University
血管平滑筋収縮蛋白の制御
- Principal Investigator
  
  野々村禎昭
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
血管平滑筋収縮蛋白の制御
- Principal Investigator
  
  野々村禎昭
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
Cキナーゼとカルシウムによる細胞増殖の制御機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
細胞膜リン脂質の動的代謝による新しいカルシウムイオンの動員機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kobe University
神経活性物質受容体によるジグリセリド産生の制御機構Principal Investigator
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kobe University
Mechanisms of signaling from cell surface receptors to nuclear genes.Principal Investigator
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Kobe University

All 2017 2016 2015 2014 2013 2011 2009 Other

All Journal Article Presentation

[Journal Article] Multiple roles of afadin in the ultrastructural morphogenesis of mouse hippocampal mossy fiber synapses.2017
- Author(s)
  Sai, K., Wang, S., Kaito, A., Fujiwara, T., Maruo, T., Itoh, Y., Miyata, M., Sakakibara, S., Miyazaki, N., Murata, K., Yamaguchi, Y., Haruta, T., Nishioka, H., Motojima, Y., Komura, M., Kimura, K., Mandai, K., Takai, Y., and Mizoguchi, A.
- Journal Title
  
  J Comp Neurol
  
  Volume : 印刷中
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26251013
[Journal Article] Developmental changes in the flotillin-1 expression pattern of the rat visual cortex.2017
- Author(s)
  Miyata M, Maruo T, Kaito A, Wang S, Yamamoto H, Fujiwara T, Mizoguchi A, Mandai K, Takai Y
- Journal Title
  
  Molecular and Cellular Neuroscience
  
  Volume : 79 Pages : 34-44
- DOI
  10.1016/j.mcn.2016.12.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06463, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19036, KAKENHI-PROJECT-26460283
[Journal Article] Nectin-4 Co-stimulates the Prolactin Receptor by Interacting with SOCS1 and Inhibiting Its Activity on the JAK2-STAT5a Signaling Pathway.2017
- Author(s)
  Maruoka, M., Kedashiro, S., Ueda, Y., Mizutani, K., and Takai, Y.
- Journal Title
  
  J Biol Chem
  
  Volume : 292 Pages : 6895-6909
- DOI
  10.1074/jbc.M116.769091
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19035
[Journal Article] Aging-dependent expression of synapse-related proteins in the mouse brain.2017
- Author(s)
  Shiotani H, Maruo T, Sakakibara S, Miyata M, Mandai K, Mochizuki H, Takai Y
- Journal Title
  
  Genes to Cells
  
  Volume : 22 Pages : 472-484
- DOI
  10.1111/gtc.12489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06463, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19036
[Journal Article] Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium.2016
- Author(s)
  Sayaka Katsunuma, Hisao Honda, Tomoyasu Shinoda, Yukitaka Ishimoto, Takaki Miyata, Hiroshi Kiyonari, Takaya Abe, Ken-ichi Nibu, Yoshimi Takai, and Hideru Togashi.
- Journal Title
  
  The Journal of Cell Biology
  
  Volume : 212 Issue : 5 Pages : 561-575
- Publisher
  Rockefeller University Press
- DOI
  10.1083/jcb.201509020
- Year and Date
  2016-02-29
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10782, KAKENHI-PROJECT-25440117, KAKENHI-PROJECT-26540158, KAKENHI-PROJECT-15K18953, KAKENHI-PLANNED-22111006, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-25440107, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26400205
[Journal Article] A novel nectin-mediated cell adhesion apparatus that is implicated in prolactin receptor signaling for mammary gland development2016
- Author(s)
  Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, Komori T, Shimono Y, Takai Y
- Journal Title
  
  J Biol Chem
  
  Volume : 291 Pages : 5817-5831
- DOI
  10.1074/jbc.M115.685917
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14381, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19035, KAKENHI-PROJECT-16K20411
[Journal Article] Regulatory role of the cell adhesion molecule nectin-1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus.2016
- Author(s)
  Geng, X., Mandai, K., Maruo, T., Wang, S., Fujiwara, T., Mizoguchi, A., Takai, Y., and Mori, M.
- Journal Title
  
  Genes Cells
  
  Volume : 21 Pages : 88-98
- DOI
  10.1111/gtc.12322
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26251013
[Journal Article] The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus2016
- Author(s)
  Kobayashi S, Hida Y, Ishizaki H, Inoue E, Tanaka-Okamoto M, Yamasaki M, Miyazaki T, Masahiro F, Kitajima I, Takai Y, Watanabe M, Ohtsuka T, Manabe T
- Journal Title
  
  Eur J Neurosci
  
  Volume : 44 Pages : 2272-2284
- DOI
  10.1111/ejn.13331
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-15H04272, KAKENHI-PROJECT-26460250, KAKENHI-PROJECT-26460251, KAKENHI-PROJECT-15K14309, KAKENHI-PROJECT-15K08612
[Journal Article] Localization of nectin-2delta at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain.2016
- Author(s)
  Miyata M, Mandai K, Maruo T, Sato J, Shiotani H, Kaito A, Itoh Y, Wang S, Fujiwara T, Mizoguchi A, Takai Y, Rikitake Y
- Journal Title
  
  Brain Research
  
  Volume : 1649 Pages : 90-101
- DOI
  10.1016/j.brainres.2016.08.023
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06463, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19036
[Journal Article] Nectin spot: a novel type of nectin-mediated cell adhesion apparatus.2016
- Author(s)
  Mizutani, K., and Takai, Y.
- Journal Title
  
  Biochem J
  
  Volume : 473 Pages : 2691-2715
- DOI
  10.1042/BCJ20160235
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] Activity-dependent alteration of the morphology of a hippocampal giant synapse.2016
- Author(s)
  Maruo, T., Mandai, K., Takai, Y., and Mori, M.
- Journal Title
  
  Mol Cell Neurosci
  
  Volume : 71 Pages : 25-33
- DOI
  10.1016/j.mcn.2015.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26251013
[Journal Article] The cell adhesion molecule necl-4/cadm4 serves as a nobel regulator for contact inhibition of cell movement and proliferation.2015
- Author(s)
  Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y.
- Journal Title
  
  PloS One.
  
  Volume : 10 Issue : 4 Pages : e0124259
- Publisher
  Public Library of Science
- DOI
  10.1371/journal.pone.0124259
- Year and Date
  2015-04-20
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24790284, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26860190, KAKENHI-PROJECT-25461128
[Journal Article] Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb.2015
- Author(s)
  Inoue T, Fujiwara T, Rikitake Y, Maruo T, Mandai K, Kimura K, Kayahara T, Wang S, Ioth Y, Sai K, Mori M, Mori K, Mizoguchi A, Takai Y.
- Journal Title
  
  J Comp Neurol.
  
  Volume : 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26114007
[Journal Article] Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb.2015
- Author(s)
  Inoue T, Fujiwara T, Rikitake Y, Maruo T, Mandai K, Kimura K, Kayahara T, Wang S, Ioth Y, Sai K, Mori M, Mori K, Mizoguchi A, Takai Y.
- Journal Title
  
  J Comp Neurol.
  
  Volume : 印刷中
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21227005
[Journal Article] Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb.2015
- Author(s)
  Inoue T, Fujiwara T, Rikitake Y, Maruo T, Mandai K, Kimura K, Kayahara T, Wang S, Ioth Y, Sai K, Mori M, Mori K, Mizoguchi A, Takai Y.
- Journal Title
  
  J Comp Neurol.
  
  Volume : 印刷中
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26251013
[Journal Article] Nectin-1 spots regulate the branching of olfactory mitral cell dendrites.2015
- Author(s)
  Fujiwara, T., Inoue, T., Maruo, T., Rikitake, Y., Ieki, N., Mandai, K., Kimura, K., Kayahara, T., Wang, S., Itoh, Y., Sai, K., Mori, M., Mori, K., Takai, Y., and Mizoguchi, A.
- Journal Title
  
  Mol Cell Neurosci
  
  Volume : 68 Pages : 143-150
- DOI
  10.1016/j.mcn.2015.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26251013
[Journal Article] Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb.2015
- Author(s)
  Inoue, T., Fujiwara, T., Rikitake, Y., Maruo, T., Mandai, K., Kimura, K, Kayahara, T, Wang, S., Itoh, Y., Sai, K., Mori, M., Mori, K., Mizoguchi, A., and Takai, Y.
- Journal Title
  
  J Comp Neurol
  
  Volume : 523 Pages : 1824-1839
- DOI
  10.1002/cne.23762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26251013
[Journal Article] Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.2015
- Author(s)
  Pujari R, Hunte R, Thomas R, van der Weyden L, Rauch D, Ratner L, Nyborg JK, Ramos JC, Takai Y, Shembade N.
- Journal Title
  
  PLoS Pathog.
  
  Volume : 16
- DOI
  10.1371/journal.ppat.1004721
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] Downregulation of CXCR4 in metastasized breast cancer cells and implication in their dormancy2015
- Author(s)
  Nobutani K, Shimono Y, Mizutani K, Ueda Y, Suzuki T, Kitayama M, Minami A, Momose K, Miyawaki K, Akashi K, Azuma T, Takai Y
- Journal Title
  
  PLoS One
  
  Volume : 10
- DOI
  10.1371/journal.pone.0130032
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14381, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic ablation of afadin.2015
- Author(s)
  Yamamoto H, Mandai K, Konno D, Maruo T, Matsuzaki F, Takai Y
- Journal Title
  
  Brain Res.
  
  Volume : 43 Pages : 775-86
- DOI
  10.1016/j.brainres.2015.05.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06727, KAKENHI-PLANNED-24113006, KAKENHI-PROJECT-26251013
[Journal Article] Quantitative analysis of the cellular composition in seminiferous tubules in normal and genetically modified infertile mice.2015
- Author(s)
  Nakata H, Wakayama T, Takai Y, Iseki S.
- Journal Title
  
  J Histochem Cytochem.
  
  Volume : 63 Issue : 2 Pages : 99-113
- Publisher
  Histochemical Society
- DOI
  10.1369/0022155414562045
- Year and Date
  2015-02-27
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-25460241
[Journal Article] Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the extended ligand-binding site.2015
- Author(s)
  Fujiwara Y, Goda N, Tamashiro T, Narita H, Satomura K, Tenno T, Nakagawa A, Oda M, Suzuki M, Sakisaka T, Takai Y, Hiroaki H.
- Journal Title
  
  Protein Science
  
  Volume : 24 Pages : 376-385
- DOI
  10.1002/pro.2628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-25293071, KAKENHI-PLANNED-26114007, KAKENHI-PUBLICLY-26117513, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26440028, KAKENHI-PROJECT-15H04337
[Journal Article] Nectins and nectin-like molecules in development and disease.2015
- Author(s)
  Mandai K, Rikitake Y, Mori M, Takai Y.
- Journal Title
  
  Curr Top Dev Biol.
  
  Volume : 112 Pages : 197-231
- DOI
  10.1016/bs.ctdb.2014.11.019
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24590354, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities2014
- Author(s)
  Fukuda T, Kominami K, Wang S, Togashi H, Hirata K, Mizoguchi A, Rikitake Y, Takai Y.
- Journal Title
  
  Development
  
  Volume : 141 Pages : 399-409
- DOI
  10.1242/dev.094995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23300284, KAKENHI-PUBLICLY-25111716, KAKENHI-PUBLICLY-25127710, KAKENHI-PROJECT-25440107, KAKENHI-PROJECT-26400205
[Journal Article] Absence of primary cilia in cell cycle-arrested human breast cancer cells2014
- Author(s)
  Nobutani K, Shimono Y, Yoshida M, Mizutani K, Minami A, Kono S, Mukohara T, Yamasaki T, Itoh T, Takao S, Minami H, Azuma T, Takai Y.
- Journal Title
  
  Genes Cells
  
  Volume : 19 Pages : 141-152
- DOI
  10.1111/gtc.12122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23501268, KAKENHI-PROJECT-24790284, KAKENHI-PUBLICLY-25130707
[Journal Article] Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.2014
- Author(s)
  Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y.
- Journal Title
  
  PLoS One
  
  Volume : 9
- DOI
  10.1371/journal.pone.0089763
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-21500372, KAKENHI-PROJECT-24590354, KAKENHI-PUBLICLY-25111716, KAKENHI-PUBLICLY-25127710, KAKENHI-PROJECT-25440107, KAKENHI-PROJECT-25860214, KAKENHI-PROJECT-26400205
[Journal Article] Suppression of the TGF-β1-induced protein expression of SNAI1 and N-cadherin by miR-199a2014
- Author(s)
  Suzuki T, Mizutani K, Minami A, Nobutani K, Kurita S, Nagino M, Shimono Y, Takai Y.
- Journal Title
  
  Genes Cells
  
  Volume : 19 Pages : 667-675
- DOI
  10.1111/gtc.12166
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23501268, KAKENHI-PROJECT-24790283, KAKENHI-PROJECT-24790284, KAKENHI-PUBLICLY-25130707, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26860190
[Journal Article] Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium2014
- Author(s)
  Tanaka-Okamoto M, Itoh Y, Miyoshi J, Mizoguchi A, Mizutani K, Takai Y, Inoue M.
- Journal Title
  
  PLoS One
  
  Volume : 9
- DOI
  10.1371/journal.pone.0110549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24790284, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26860190
[Journal Article] s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin2014
- Author(s)
  Kobayashi R, Kurita S, Miyata M, Maruo T, Mandai K, Rikitake Y, Takai Y.
- Journal Title
  
  Genes Cells
  
  Volume : 19 Pages : 853-863
- DOI
  10.1111/gtc.12185
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24590354, KAKENHI-PROJECT-24790283, KAKENHI-PROJECT-25860214, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.2014
- Author(s)
  Yoshida T, Iwata T, Takai Y, Birchmeier W, Yamato M, Okano T.
- Journal Title
  
  Genes Cells.
  
  Volume : 19 Pages : 842-852
- DOI
  10.1111/gtc.12184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.2014
- Author(s)
  Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, Smyth SS, Li Z, Takai Y, Whiteheart SW.
- Journal Title
  
  J Clin Invest.
  
  Volume : 124 Pages : 4517-4528
- DOI
  10.1172/JCI75572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.2014
- Author(s)
  Zhu Q, Yamakuchi M, Ture S, de la Luz Garcia-Hernandez M, Ko KA, Modjeski KL, LoMonaco MB, Johnson AD, O'Donnell CJ, Takai Y, Morrell CN, Lowenstein CJ.
- Journal Title
  
  J Clin Invest
  
  Volume : 124 Pages : 4503-4516
- DOI
  10.1172/JCI71245
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26293130
[Journal Article] Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain2013
- Author(s)
  Yamamoto H, Maruo T, Majima T, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Mandai K, Takai Y.
- Journal Title
  
  PLoS One
  
  Volume : 8
- DOI
  10.1371/journal.pone.0080356
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PUBLICLY-24111532
[Journal Article] Nectin and junctional adhesion molecule are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells.2013
- Author(s)
  Yamada T, Kuramitsu K, Rikitsu E, Kurita S, Ikeda W, Takai Y.
- Journal Title
  
  Genes Cells.
  
  Volume : 18 Pages : 985-998
- DOI
  10.1111/gtc.12091
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005
[Journal Article] Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain.2013
- Author(s)
  Ratta-Apha W, Hishimoto A, Mouri K, Shiroiwa K, Sasada T, Yoshida M, Supriyanto I, Ueno Y, Asano M, Shirakawa O, Togashi H, Takai Y, Sora I.
- Journal Title
  
  Neurosci Res.
  
  Volume : 77 Pages : 222-227
- DOI
  10.1016/j.neures.2013.08.010
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005
[Journal Article] Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.2013
- Author(s)
  Kurita S, Yamada T, Rikitsu E, Ikeda W, Takai Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume : 288 Pages : 29356-29368
- DOI
  10.1074/jbc.M113.453464
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24790283
[Journal Article] Necl-2/CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons.2013
- Author(s)
  Yamada A, Inoue E, Deguchi-Tawarada M, Matsui C, Togawa A, Nakatani T, Ono Y, Takai Y.
- Journal Title
  
  Mol Cell Neurosci.
  
  Volume : 56 Pages : 234-243
- DOI
  10.1016/j.mcn.2013.06.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005
[Journal Article] Statins exert pleiotropic effects through SmgGDS up-regulation with a resultant Rac1 degradation2013
- Author(s)
  Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H.
- Journal Title
  
  Arterioscler Throm VascBiol
  
  Volume : 33 Pages : 1591-1600
- DOI
  10.1161/ATVBAHA.112.300922
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-22390154, KAKENHI-PROJECT-23659071, KAKENHI-PROJECT-25461100, KAKENHI-PROJECT-25670379
[Journal Article] Interaction of Necl-4/CADM4 with ErbB3 and integrin a6b4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.2013
- Author(s)
  Sugiyama H, Mizutani K, Kurita S, Okimoto N, Shimono Y, Takai Y.
- Journal Title
  
  Genes Cells
  
  Volume : 18 Pages : 519-528
- DOI
  10.1111/gtc.12056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23501268, KAKENHI-PROJECT-24790284, KAKENHI-PUBLICLY-23130510
[Journal Article] Nectin-like molecule-5 regulates intimal thickening following carotid artery ligation in mice2013
- Author(s)
  Kureha F, Satomi-Kobayashi S, Kubo Y, Kinugasa M, Ishida T, Takai Y, Hirata K, Rikitake Y.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume : 33 Pages : 1206-1211
- DOI
  10.1161/ATVBAHA.113.301425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-25461128
[Journal Article] Regulation of dendritic filopodial interactions by ZO-1 and implications for dendrite morphogenesis.2013
- Author(s)
  Komaki R, Togashi H, Takai Y.
- Journal Title
  
  PLoS One.
  
  Volume : 8
- DOI
  10.1371/journal.pone.0076201
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21227005
[Journal Article] Reduction of ST6GAL1-catalyzed Sialylation of Nectin-like Molecule 2/Cell Adhesion Molecule 1 and Enhancement of the ErbB2/ErbB3 Signaling by MicroRNA-199a2013
- Author(s)
  Minami A, Shimono Y, Mizutani K, Nobutani K, Momose K, Azuma T, Takai Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume : 288 Pages : 11845-11853
- DOI
  10.1074/jbc.M112.405993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24790284, KAKENHI-PROJECT-23501268, KAKENHI-PUBLICLY-23130510
[Presentation] Roles of afadin in the development of the cellular architecture of the hippocampus.2016
- Author(s)
  宮田宗明、丸尾知彦、山本昆明、垣内愛加、王淑杰、藤原武志、溝口明、萬代研二、高井義美
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] ネクチン-2αとマウス手綱核2016
- Author(s)
  塩谷元、萬代研二、宮田宗明、丸尾知彦、垣内愛加、王淑杰、藤原武志、溝口明、望月秀樹、高井義美
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] SBF-SEM 3D reconstitution analysis reveals alterations in composition and morphology of mouse hippocampal mossy fiber synapses by afadin knockout2015
- Author(s)
  Takeshi Fujiwara, Shujie Wang, Yu Itoh, Kousyoku Sai, Aika Kaito, Naoyuki Miyazaki, Kazuyoshi Murata, Tomohiko Maruo, Hideaki Yamamoto, Kenji Mandai, Yoshimi Takai, Akira Mizoguchi
- Organizer
  第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
- Place of Presentation
  神戸国際会議場・展示場
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] AdAMS: Activith-dependent alteration of morphology of a hippocampal mossy fiber bouton.2015
- Author(s)
  Maruo Tomohiko, Mandai Kenji, Takai Yoshimi, Mori Masahiro
- Organizer
  第３８回日本神経科学大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] 転移乳がん細胞におけるCXCR4の発現低下とがん休眠との関連2015
- Author(s)
  上田悠貴、信谷健太郎、下野洋平、水谷清人、鈴木俊裕、北山美登里、南晶洋、百瀬健次、宮脇恒太、赤司浩一、東健、高井義美
- Organizer
  第７４回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] 細胞の接着とシグナル伝達2015
- Author(s)
  高井義美
- Organizer
  第３８回日本分子生物学会年会・第８８回日本生化学会大会　合同大会　(BMB2015)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] 乳腺分化を制御する新規のネクチン依存性細胞間接着装置2015
- Author(s)
  圓岡真宏、北山美登里、水谷清人、高井義美
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会（BMB2015）
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-26114007
[Presentation] 乳腺分化を制御する新規のネクチン依存性細胞間接着装置2015
- Author(s)
  圓岡真宏、北山-吉田美登里、水谷清人、高井義美
- Organizer
  第３８回日本分子生物学会年会・第８８回日本生化学会大会　合同大会　(BMB2015)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] 細胞の接着とシグナル伝達2015
- Author(s)
  高井義美
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会（BMB2015）
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PLANNED-26114007
[Presentation] 転移乳がんにおけるCXCR4の発現低下とがん休眠との関連2015
- Author(s)
  上田悠貴、信谷健太郎、下野洋平、水谷清人、鈴木俊裕、北山美登里、南晶洋、百瀬健次、宮脇恒太、赤司浩一、東健、高井義美
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PLANNED-26114007
[Presentation] 細胞のがん化と細胞接着装置2011
- Author(s)
  高井義美
- Organizer
  第７０回日本癌学会学術総会　モーニングレクチャー
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Roles of nectins in heterotypic cell adhesion.2011
- Author(s)
  Yoshimi Takai
- Organizer
  5th Mechanobiology Conference 2011
- Place of Presentation
  Singapore
- Invited
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] 異種細胞間接着形成におけるネクチンの機能と作用機構2011
- Author(s)
  高井義美
- Organizer
  第２８回日本医学会総会２０１１
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Roles and modes of action of nectin in adhesion between heterogeneous cells.2011
- Author(s)
  Yoshimi Takai
- Organizer
  Gordon Research Conference on Cell Contact & Adhesion 2011
- Place of Presentation
  Vermont, USA
- Invited
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Nectins and nectin-like molecules : roles and modes of action in tumorigenesis, invasion, and metastasis2009
- Author(s)
  Yoshimi Takai
- Organizer
  Global COE international Symposium"New Aspects in Immunology and Cancer Research"
- Place of Presentation
  秋田大学(秋田県)
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Regulatory Mechanism of Active Zone Formation by Nectin-Afadin Adhesion System2009
- Author(s)
  Yoshimi Takai
- Organizer
  "Current Trends in Biomedicine"workshop"Active Zones as organizers of neuronal communication"
- Place of Presentation
  UNIA(Spain)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] SBF-SEM 3D reconstitution analysis reveals alterations in composition and morphology of mouse hippocampal mossy fiber synapses by afadin knockout.
- Author(s)
  Takeshi Fujiwara, Shujie Wang, Yu Itoh, Kousyoku Sai, Aika Kaito, Naoyuki Miyazaki, Kazuyoshi Murata, Tomohiko Maruo, Hideaki Yamamoto, Kenji Mandai, Yoshimi Takai, Akira Mizoguchi
- Organizer
  第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
- Place of Presentation
  神戸国際会議場・展示場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PLANNED-26114007
[Presentation] Afadin plays an important role in formation of puncta adherentia junction and differentiation of presynapses in hippocampal neurons.
- Author(s)
  Daisaku Toyoshima, Kenji Mandai, Tomohiko Maruo, Irwan Supriyanto, Hideru Togashi, Takahito Inoue, Masahiro Mori, Yoshimi Takai
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] Afadin-deficiency leads to the formation of double cortex by abnormal radial glial scaffold and cell-autonomous impairment of neuronal migration during development.
- Author(s)
  Hideaki Yamamoto, Kenji Mandai, Daijiro Konno, Tomohiko Maruo, Fumio Matsuzaki, Yoshimi Takai
- Organizer
  2014 CSHL Conference on Glia in Health & Disease
- Place of Presentation
  New York, NY, USA
- Year and Date
  2014-07-17 – 2014-07-21
- Data Source
  KAKENHI-PLANNED-26114007
[Presentation] マイクロRNA-199aはTGFβ－1で誘導されるSNAI1とN-cadherinの発現を抑制する
- Author(s)
  鈴木俊裕、水谷清人、南晶洋、信谷健太郎、梛野正人、下野洋平、高井義美
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PLANNED-26114007
[Presentation] シグナル伝達と細胞接着―研究の歴史と展望―
- Author(s)
  高井義美
- Organizer
  第１００回日本消化器病学会総会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-23 – 2014-04-26
- Invited
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] Afadin-deficiency leads to the formation of double cortex by abnormal radial glial scaffold and cell-autonomous impairment of neuronal migration during development.
- Author(s)
  Hideaki Yamamoto, Kenji Mandai, Daijiro Konno, Tomohiko Maruo, Fumio Matsuzaki, Yoshimi Takai
- Organizer
  2014 CSHL Conference on Glia in Health & Disease
- Place of Presentation
  New York, NY, USA
- Year and Date
  2014-07-17 – 2014-07-21
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Afadin plays an important role in formation of puncta adherentia junction and differentiation of presynapses in hippocampal neurons.
- Author(s)
  Daisaku Toyoshima, Kenji Mandai, Tomohiko Maruo, Irwan Supriyanto, Hideru Togashi, Takahito Inoue, Masahiro Mori, Yoshimi Takai
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] SBF-SEM 3D reconstitution analysis reveals alterations in composition and morphology of mouse hippocampal mossy fiber synapses by afadin knockout.
- Author(s)
  Takeshi Fujiwara, Shujie Wang, Yu Itoh, Kousyoku Sai, Aika Kaito, Naoyuki Miyazaki, Kazuyoshi Murata, Tomohiko Maruo, Hideaki Yamamoto, Kenji Mandai, Yoshimi Takai, Akira Mizoguchi
- Organizer
  第１２０回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
- Place of Presentation
  神戸国際会議場・展示場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Nectin and afadin in cell adhesion and signaling.
- Author(s)
  Yoshimi Takai
- Organizer
  Symposium on Membrane Biology, Univesity of Washington and Kobe University
- Place of Presentation
  Seattle, WA, USA
- Year and Date
  2014-03-27 – 2014-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] シグナル伝達と細胞接着―研究の歴史と展望―
- Author(s)
  高井義美
- Organizer
  第１００回日本消化器病学会総会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-23 – 2014-04-26
- Invited
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] マイクロRNA-199aはTGFβ－1で誘導されるSNAI1とN-cadherinの発現を抑制する
- Author(s)
  鈴木俊裕、水谷清人、南晶洋、信谷健太郎、梛野正人、下野洋平、高井義美
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Afadin-deficiency leads to the formation of double cortex by abnormal radial glial scaffold and cell-autonomous impairment of neuronal migration during development.
- Author(s)
  Hideaki Yamamoto, Kenji Mandai, Daijiro Konno, Tomohiko Maruo, Fumio Matsuzaki, Yoshimi Takai
- Organizer
  2014 CSHL Conference on Glia in Health & Disease
- Place of Presentation
  New York, NY, USA
- Year and Date
  2014-07-17 – 2014-07-21
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] Nectins Regulate the Mosaic Cellular Pattern Formation in the Olfactory Epithelium.
- Author(s)
  Sayaka Katsunuma, Hideru Togashi , Ken-ichi Nibu and Yoshimi Takai
- Organizer
  16th Asian Research Symposium in Rhinology (ARSR)
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2013-08-29 – 2013-08-31
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Afadin plays an important role in formation of puncta adherentia junction and differentiation of presynapses in hippocampal neurons.
- Author(s)
  Daisaku Toyoshima, Kenji Mandai, Tomohiko Maruo, Irwan Supriyanto, Hideru Togashi, Takahito Inoue, Masahiro Mori, Yoshimi Takai
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PLANNED-26114007
[Presentation] マイクロRNA-199aはTGFβ－1で誘導されるSNAI1とN-cadherinの発現を抑制する
- Author(s)
  鈴木俊裕、水谷清人、南晶洋、信谷健太郎、梛野正人、下野洋平、高井義美
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26251013

1. KAIBUCHI Kozo (00169377)

# of Collaborated Projects : 18results

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2. SASAKI Takuya (40241278)

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TAKAI Yoshimi 高井 義美

Research Projects

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Co-Researchers

上皮細胞の競合に関与する細胞間接着分子の同定と作用機構の解明Principal InvestigatorOngoing

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Roles and modes of action of nectins in heterotypic cell-cell adhesionsPrincipal Investigator

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Cell competition: a mechanism for survival of the fittest in the multi-cellular communityOngoing

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Roles of Cell Adhesion and Signaling in Cell MorphogenesisPrincipal Investigator

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Role of cell adhesion signaling in the abnormal cell polarization of cancer cellsPrincipal Investigator

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Disorganization of cell and tissue systems in cancerPrincipal Investigator

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細胞増殖のシグナリング機構Principal Investigator

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がんの生物学的特性に関する研究の総括Principal Investigator

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TAKAI Yoshimi 高井義美