Shimizu Kazuya 清水一也

… Alternative Names

SHIMIZU Kazuya 清水一也

清水一也シミズカズヤ

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Researcher Number	50335353
Other IDs
Affiliation (Current)	2023: 神戸大学, 保健学研究科, 保健学研究員
Affiliation (based on the past Project Information) *help	2023: 神戸大学, 保健学研究科, 保健学研究員 2016 – 2021: 神戸大学, 保健学研究科, 保健学研究員 2011 – 2015: 神戸大学, 保健学研究科, 研究員 2014: 神戸大学, 保健学研究科, 保健学研究員 2002 – 2003: 大阪大学, 医学系研究科, 助手 2001: 大阪大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 50010:Tumor biology-related / Pathological medical chemistry Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery / Biological Sciences
Keywords	Principal Investigator 膵臓癌 / 膵臓がん / 微小環境 / 癌幹細胞 / がん幹細胞 / オルガノイド / 神経浸潤 / CD133 / 抗がん剤耐性 / 膵癌 … More / がん微小環境 / iPS / 癌微小環境 / 膵臓外科学 / 胚性幹細胞 / 受精卵 / c-Jun N-terminal kinase / 細胞極性形成 / シナプス形成 / Cdc42 / Rac / 細胞間接着 / カドヘリン / 細胞分化 / アファディン / ネクチン … More Except Principal Investigator 膵臓癌 / エクソソーム / 膵臓がん / 遠隔転移 / 抗がん剤耐性 / 肝転移 / 癌幹細胞 / がん幹細胞 / ゲムシタビン / 膵癌 / 膵臓外科学 / 膵がん / 肝臓転移 / 微小環境 / がん微小環境 / Frabin-Cdc42系 / Nectin-Afadin-Ponsin系 / Rab11 / Gab-1 / Frabin-Cdc42 / Nectin-Afadin / Cadherin-Catenin系 / Nectin-Afadin系 / がん / Necl-5 / Rac / Cdc42 / ネクチン / 細胞運動 / 細胞接着 / 細胞増殖 Less

抗がん剤耐性膵臓癌に対するモノアミンオキシダーゼB阻害剤の抗腫瘍効果に関する研究
- Principal Investigator
  
  三好真琴
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
Establishment of organoid culture method to reconstruct neural invasion of pancreatic cancer cellsPrincipal Investigator
- Principal Investigator
  
  清水一也
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kobe University
The mechanism of promoting remote metastasis by exosome derived from pancreatic cancer
- Principal Investigator
  
  堀裕一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
Pancreatic cancer derived exosomes promote early liver metastasis
- Principal Investigator
  
  Hori Yuichi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
Establishment of novel target therapy for K-ras/MMP-10 signaling pathway in chemotherapy-resistant pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Shimizu Kazuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kobe University
Targeting strategy to inhibit liver metastasis for pancreatic cancer
- Principal Investigator
  
  HORI YUICHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kobe University
Reconstruction of pancreatic cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  SHIMIZU KAZUYA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kobe University
Reconstitution of microenvironment surrounding pancreatic cancer
- Principal Investigator
  
  HORI YUICHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kobe University
Targeting therapy using chemotherapy-resistant pancreatic cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Kazuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kobe University
細胞間接着による細胞分化の制御機構Principal Investigator
- Principal Investigator
  
  清水一也
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
細胞増殖のシグナリング機構
- Principal Investigator
  
  高井義美
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012

All Journal Article Presentation

[Journal Article] Pancreatic cancer cell-derived exosomes induce epithelial-mesenchymal transition in human pancreatic cancer cells themselves partially via transforming growth factor β12022
- Author(s)
  Nakayama F , Miyoshi M , Kimoto A , Kawano A, Miyashita K , Kamoshida S , Shimizu K , Hori Y
- Journal Title
  
  Med Mol Morphol
  
  Volume: - Issue: 3 Pages: 227-235
- DOI
  10.1007/s00795-022-00321-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08705, KAKENHI-PROJECT-21K07099, KAKENHI-PROJECT-21K08684
[Journal Article] Xenografts Derived From Patients? Ascites Recapitulate the Gemcitabine Resistance Observed in Pancreatic Cancer Patients2019
- Author(s)
  Machinaga Akihito、Hori Yuichi、Shimizu Kazuya、Okahara Kyohei、Yanagita Emmy、Miyoshi Makoto、Itoh Tomoo、Sasai Ken
- Journal Title
  
  Pancreas
  
  Volume: 48 Issue: 10 Pages: 1294-1302
- DOI
  10.1097/mpa.0000000000001438
- NAID
  120006777076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08705, KAKENHI-PROJECT-17K10697
[Journal Article] Gemcitabine enhances Kras-MEK-induced matrix metalloproteinase-10 expression via histone acetylation in gemcitabine-resistant pancreatic tumor-initiating cells.2017
- Author(s)
  Shimizu K, Nishiyama T, Hori Y
- Journal Title
  
  Pancreas
  
  Volume: 46 Issue: 2 Pages: 268-275
- DOI
  10.1097/mpa.0000000000000744
- NAID
  120005970750
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462059, KAKENHI-PROJECT-15K10183, KAKENHI-PROJECT-17K10697
[Journal Article] Gemcitabine Enhances Kras-MEK-induced Matrix Metalloproteinase-10 Expression via Histone Acetylation in Gemcitabine-resistant Pancreatic Tumor-initiating Cells2016
- Author(s)
  Shimizu K, Nishiyama T, Hori Y
- Journal Title
  
  Pancreas
  
  Volume: 未定
- NAID
  120005970750
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462059
[Journal Article] Novel cell line and animal model for human biliary tract cancer2016
- Author(s)
  Shinozaki K, Ajiki T, Murakami S, Matsumoto T, Akita M, Shimizu K, Hori Y
- Journal Title
  
  Medical Research Archieves
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10183
[Journal Article] Novel cell line and animal model for human biliary tract cancer2016
- Author(s)
  Shinozaki K, Ajiki T, Murakami S, Matsumoto T, Akita M, Shimizu K, Hori Y
- Journal Title
  
  Medical Research Archieves
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462059
[Journal Article] Gemcitabine Enhances Kras-MEK-induced Matrix Metalloproteinase-10 Expression via Histone Acetylation in Gemcitabine-resistant Pancreatic Tumor-initiating Cells2016
- Author(s)
  Shimizu K, Nishiyama T, Hori Y
- Journal Title
  
  Pancreas
  
  Volume: 未定
- NAID
  120005970750
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10183
[Journal Article] Identification of a novel subpopulation of tumor-initiating cells from gemcitabine-resistant pancreatic ductal adenocarcinoma patients.2013
- Author(s)
  Shimizu K, Chiba S, Hori Y.
- Journal Title
  
  PLoS One.
  
  Volume: 21 Issue: 11 Pages: e81283-e81283
- DOI
  10.1371/journal.pone.0081283
- NAID
  120005356910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592007, KAKENHI-PROJECT-24592025
[Journal Article] Distinct expression of CD133 between intraductal papillary neoplasms of the bile duct and bile duct adenocarcinomas2012
- Author(s)
  Ohtsubo I, Ajiki T, Hori Y, Murakami S, Shimizu K, Fukumoto T, Ku Y.
- Journal Title
  
  Hepatol Res.
  
  Volume: Vol.42 Pages: 574-582
- NAID
  10031144272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592007
[Presentation] Patient-derived orthotopic pancreatic cancer tissue xenografts recapitulate remote metastasis and cancer-associated hypercoagulation2021
- Author(s)
  Miyashita K, Miyoshi M, Kimoto A, Ohnaga T, Shimizu K, Hori Y
- Organizer
  American pancreatic Association 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] Patient-derived orthotopic pancreatic cancer tissue xenografts recapitulate remote metastasis and cancer-associated hypercoagulation2021
- Author(s)
  Miyashita K, Miyoshi M, Kimoto A,Ohnaga T, Shimizu K, Hori Y
- Organizer
  American pancreatic Association
- Data Source
  KAKENHI-PROJECT-21K07099
[Presentation] 膵臓がん細胞由来のエクソソームは自身の上皮間葉転換を誘発する2021
- Author(s)
  木本愛、中山郁也、三好真琴、宮下久美子、後藤百香、河野朱莉、前谷織江、渡邊ありさ、大永智貴、清水一也、堀裕一
- Organizer
  第52回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌患者由来腫瘍片の同所性異種移植は遠隔転移とがん関連凝固異常を再現できる2021
- Author(s)
  大永智貴、渡邊ありさ、三好真琴、宮下久美子、後藤百香、中山郁也、河野朱莉、前谷織江、木本愛、清水一也、堀裕一
- Organizer
  第30回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-21K07099
[Presentation] Pancreatic cancer cell-derived exosomes induce their own epithelial-mesenchymal transition2021
- Author(s)
  Miyoshi M, Miyashita K, Kimoto A,Ohnaga T, Shimizu K, Hori Y
- Organizer
  American pancreatic Association
- Data Source
  KAKENHI-PROJECT-21K07099
[Presentation] Patient-derived orthotopic pancreatic cancer tissue xenografts recapitulate remote metastasis and cancer-associated hypercoagulation2021
- Author(s)
  Miyashita K, Miyoshi M, Kimoto A, Ohnaga T, Shimizu K, Hori Y
- Organizer
  American pancreatic Association 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08684
[Presentation] Patient-derived orthotopic pancreatic cancer tissue xenografts recapitulate remote metastasis and cancer-associated hypercoagulation2021
- Author(s)
  Miyashita K, Miyoshi M, Shimizu K, Kawano A, Hori Y
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌患者由来腫瘍片の同所性異種移植は遠隔転移とがん関連凝固異常を再現できる2021
- Author(s)
  大永智貴、渡邊ありさ、三好真琴、宮下久美子、後藤百香、中山郁也、河野朱莉、前谷織江、木本愛、清水一也、堀裕一
- Organizer
  第30回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-21K08684
[Presentation] Patient-derived orthotopic pancreatic cancer tissue xenografts recapitulate remote metastasis and cancer-associated hypercoagulation2021
- Author(s)
  Miyashita K, Miyoshi M, Shimizu K, Kawano A, Hori Y
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-21K07099
[Presentation] 膵臓がん細胞由来のエクソソームは自身の上皮間葉転換を誘発する2021
- Author(s)
  木本愛、中山郁也、三好真琴、宮下久美子、後藤百香、河野朱莉、前谷織江、渡邊ありさ、大永智貴、清水一也、堀裕一
- Organizer
  第52回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-21K08684
[Presentation] 膵臓がん細胞由来エクソソームは血管内皮細胞を傷害して遠隔転移を亢進する2021
- Author(s)
  堀裕一、清水一也、三好真琴、寺田夢、脇田美音、大下彩、高嶋宏滋、宮下久美子、後藤百香、中山郁也、河野朱莉、前谷織江、渡邊ありさ、味木徹夫
- Organizer
  第51回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵臓がんorthotopic allograft implantationマウスモデルの開発2021
- Author(s)
  渡邊ありさ、清水一也、三好真琴、寺田夢、脇田美音、大下彩、高嶋宏滋、宮下久美子、後藤百香、中山郁也、河野朱莉、前谷織江、味木徹夫、堀裕一
- Organizer
  第51回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] Pancreatic cancer cell-derived exosomes induce their own epithelial-mesenchymal transition2021
- Author(s)
  Miyoshi M, Miyashita K, Kimoto A, Ohnaga T, Shimizu K, Hori Y
- Organizer
  American pancreatic Association 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08684
[Presentation] 膵臓がん細胞由来のエクソソームは自身の上皮間葉転換を誘発する2021
- Author(s)
  木本愛、中山郁也、三好真琴、宮下久美子、後藤百香、河野朱莉、前谷織江、渡邊ありさ、大永智貴、清水一也、堀裕一
- Organizer
  第52回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-21K07099
[Presentation] Patient-derived orthotopic pancreatic cancer tissue xenografts recapitulate remote metastasis and cancer-associated hypercoagulation2021
- Author(s)
  Miyashita K, Miyoshi M, Shimizu K, Kawano A, Hori Y
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-21K08684
[Presentation] Pancreatic cancer cell-derived exosomes induce their own epithelial-mesenchymal transition2021
- Author(s)
  Miyoshi M, Miyashita K, Kimoto A, Ohnaga T, Shimizu K, Hori Y
- Organizer
  American pancreatic Association 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌患者由来腫瘍片の同所性異種移植は遠隔転移とがん関連凝固異常を再現できる2021
- Author(s)
  大永智貴、渡邊ありさ、三好真琴、宮下久美子、後藤百香、中山郁也、河野朱莉、前谷織江、木本愛、清水一也、堀裕一
- Organizer
  第30回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] Exosomes from pancreatic cancer cells promote distant metastasis due to injured vascular endothelial cells2020
- Author(s)
  Akari Kawano, Kazuya Shimizu, Makoto Miyoshi, Kumiko Miyashita, Yume Terada, Mion Wakita, Aya Oshimo, Hiroshi Takashima, Yuichi Hori
- Organizer
  第79回日本癌学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵臓がん同所性移植片移植マウスモデルの開発2020
- Author(s)
  前谷織江、三好真琴、清水一也、宮下久美子、後藤百香、堀裕一
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵臓がん細胞のorthotopic allograft implantationマウスモデルの開発2020
- Author(s)
  中山郁也、清水一也、三好真琴、寺田夢、脇田美音、大下彩、高嶋宏滋、宮下久美子、渡邊ありさ、後藤百香、河野朱莉、前谷織江、味木徹夫、堀裕一
- Organizer
  JDDW2020
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] Monoamine oxidase B inhibitor has anti-proliferative effect on Gemcitabine-resistant pancreatic cancer cells2020
- Author(s)
  Kumiko Miyashita, Makoto Miyoshi, Kazuya Shimizu, Ken Sasai, Tsuyoshi Akagi, Yuichi Hori
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] 膵臓がん細胞由来エクソソームは血管内皮細胞を傷害して遠隔転移を亢進する2020
- Author(s)
  後藤百香、清水一也、三好真琴、寺田夢、脇田美音、大下彩、高嶋宏滋、宮下久美子、渡邊ありさ、中山郁也、河野朱莉、前谷織江、堀裕一
- Organizer
  第29回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵臓がんorthotopic allograft implantationマウスモデルの開発2020
- Author(s)
  前谷織江、清水一也、三好真琴、寺田夢、脇田美音、大下彩、高嶋宏滋、宮下久美子、渡邊ありさ、後藤百香、中山郁也、河野朱莉、堀裕一
- Organizer
  第29回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] 膵臓がん細胞由来エクソソームは血管内皮細胞を傷害して遠隔転移を亢進する2020
- Author(s)
  後藤百香、三好真琴、清水一也、宮下久美子、前谷織江、堀裕一
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌細胞由来エクソソームは肝転移を亢進する2019
- Author(s)
  高嶋宏滋、清水一也、鶴田大生、梅本陵平、寺田夢、脇田美音、大下彩、三好真琴、味木徹夫、堀裕一
- Organizer
  第50回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] ヒト膵癌細胞由来エクソソームは肝転移を亢進する2019
- Author(s)
  脇田美音、清水一也、鶴田大生、梅本陵平、寺田夢、大下彩、高嶋宏滋、宮下久美子、三好真琴、堀裕一
- Organizer
  第28回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌細胞由来エクソソームは遠隔転移を亢進する2019
- Author(s)
  鶴田大生、清水一也、梅本陵平、大下彩、寺田夢、高嶋宏滋、脇田美音、宮下久美子、三好真琴、堀裕一
- Organizer
  第51回日本臨床分子形態学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] ヒト膵癌細胞由来エクソソームは肝転移を亢進する2019
- Author(s)
  大下彩、清水一也、鶴田大生、梅本陵平、寺田夢、高嶋宏滋、脇田美音、宮下久美子、三好真琴、堀裕一
- Organizer
  第27回JDDW
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌細胞由来エクソソームは遠隔転移を亢進する2019
- Author(s)
  鶴田大生、清水一也、梅本陵平、大下彩、寺田夢、高嶋宏滋、脇田美音、宮下久美子、三好真琴、堀裕一
- Organizer
  第51回日本臨床分子形態学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌細胞由来エクソソームは肝転移を亢進する2019
- Author(s)
  高嶋宏滋、清水一也、鶴田大生、梅本陵平、寺田夢、脇田美音、大下彩、三好真琴、味木徹夫、堀裕一
- Organizer
  第50回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌細胞由来エクソソームは肝転移を亢進する2019
- Author(s)
  大下彩、清水一也、鶴田大生、梅本陵平、寺田夢、高嶋宏滋、脇田美音、宮下久美子、三好真琴、堀裕一
- Organizer
  第27回JDDW
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] ヒト膵癌細胞由来エクソソームは遠隔転移を亢進する2019
- Author(s)
  寺田夢、清水一也、鶴田大生、梅本陵平、脇田美音、大下彩、高嶋宏滋、宮下久美子、三好真琴、堀裕一
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] ヒト膵癌細胞由来エクソソームは遠隔転移を亢進する2019
- Author(s)
  寺田夢、清水一也、鶴田大生、梅本陵平、脇田美音、大下彩、高嶋宏滋、宮下久美子、三好真琴、堀裕一
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] 抗がん剤耐性の膵臓癌に対する脂質メディエーターの効果2019
- Author(s)
  梅本陵平、清水一也、鶴田大生、大下彩、高嶋宏滋、寺田夢、脇田美音、三好真琴、堀裕一
- Organizer
  第51回日本臨床分子形態学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] 抗がん剤耐性の膵臓癌に対する脂質メディエーターの効果2019
- Author(s)
  梅本陵平、清水一也、鶴田大生、大下彩、高嶋宏滋、寺田夢、脇田美音、三好真琴、堀裕一
- Organizer
  第51回日本臨床分子形態学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] ヒト膵癌細胞由来エクソソームは肝転移を亢進する2019
- Author(s)
  脇田美音、清水一也、鶴田大生、梅本陵平、寺田夢、大下彩、高嶋宏滋、宮下久美子、三好真琴、堀裕一
- Organizer
  第28回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] 抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立とその解析2018
- Author(s)
  鶴田大生、清水一也、梅本陵平、角井祐介、竹垣普恵、西村綾乃、三好真琴、赤城剛、笹井研、堀裕一
- Organizer
  第49回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] 抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立とその解析2018
- Author(s)
  梅本陵平、清水一也、鶴田大生、角井祐介、竹垣普恵、西村綾乃、三好真琴、堀裕一
- Organizer
  第50回日本臨床分子形態学会
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] 抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立とその解析2018
- Author(s)
  梅本陵平、清水一也、鶴田大生、角井祐介、竹垣普惠、西村綾乃、三好真琴、堀裕一
- Organizer
  第50回日本臨床分子形態学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] 抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立とその解析2018
- Author(s)
  鶴田大生、清水一也、梅本陵平、角井祐介、竹垣普惠、西村綾乃、三好真琴、赤城剛、笹井研、堀裕一
- Organizer
  第49回日本膵臓学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] Ascites-derived PDX models effectively recapitulate the gemcitabine-resistance observed in pancreatic cancer patients.2018
- Author(s)
  Akihito Machinaga, Yuichi Hori, Kazuya Shimizu, Kyohei Okahara, Makoto miyoshi, Tomoo Itho, Ken Sasai
- Organizer
  AACR special conference on Pancreatic Cancer: Advances in Science and Clinical Care
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08705
[Presentation] Ascites-derived-PDX models effectively recapitulate the gemcitabine-resistance observed in pancreatic cancer patients.2018
- Author(s)
  Akihito Mochinaga, Yuichi Hori, Kazuya Shimizu, Kyohei Okahara, Makoto Miyoshi, Tomoi Itho, Ken Sasai
- Organizer
  AACR special conference on Pancreatic Cancer: Advances in Science and Clinical Care
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] Gemcitabine Enhances Kras-MEK-induced Matrix Metalloproteinase-10 Expression in Gemcitabine-resistant Pancreatic Tumor-initiating Cells2017
- Author(s)
  Ayano Nishimura, Kazuya Shimizu, Yusuke Kadoi, Yukie Takegaki,Makoto Miyoshi,Yuichi Hori
- Organizer
  アメリカ膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] がん遺伝子を導入したマウス膵臓組織幹細胞はがん幹細胞様の表現型を示す2017
- Author(s)
  竹垣普惠、清水一也、角井祐介、西村綾乃、三好真琴、赤城剛、笹井研、堀裕一
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] 抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立と解析2017
- Author(s)
  角井祐介、清水一也、竹垣普惠、西村綾乃、三好真琴、赤城剛、笹井研、堀裕一
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] Oncogene transduced mouse pancreatic stem/progenitor cells show phenotypes similar to tumor-initiating cells2017
- Author(s)
  Yukie Takegaki, Kazuya Shimizu, Yusuke Kadoi, Ayano Nishimura, Makoto Miyoshi, Tsuyoshi Akagi, Ken Sasai, Yuichi Hori
- Organizer
  アメリカ膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] Gemcitabine Enhances Kras-MEK-induced Matrix Metalloproteinase-10 Expression in Gemcitabine-resistant Pancreatic Tumor-initiating Cells2017
- Author(s)
  Ayano Nishimura, Kazuya Shimizu, Yusuke Kadoi, Yukie Takegaki,Makoto Miyoshi,Yuichi Hori
- Organizer
  アメリカ膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] がん遺伝子を導入したマウス膵臓組織幹細胞はがん幹細胞様の表現型を示す2017
- Author(s)
  竹垣普惠、清水一也、角井祐介、西村綾乃、三好真琴、赤城剛、笹井研、堀裕一
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] Oncogene transduced mouse pancreatic stem/progenitor cells show phenotypes similar to tumor-initiating cells2017
- Author(s)
  Yukie Takegaki, Kazuya Shimizu, Yusuke Kadoi, Ayano Nishimura, Makoto Miyoshi, Tsuyoshi Akagi, Ken Sasai, Yuichi Hori
- Organizer
  アメリカ膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] 抗がん剤耐性膵癌細胞ではヒストンアセチル化を介したKras-MEK-Matrix Metalloproteinase-10シグナルがGemcitabine投与で増強する2017
- Author(s)
  西村綾乃、清水一也、角井祐介、竹垣普惠、三好真琴、堀裕一
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] 抗がん剤耐性膵癌細胞ではヒストンアセチル化を介したKras-MEK-Matrix Metalloproteinase-10シグナルがGemcitabine投与で増強する2017
- Author(s)
  西村綾乃、清水一也、角井祐介、竹垣普惠、三好真琴、堀裕一
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K10697
[Presentation] 抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立と解析2017
- Author(s)
  角井祐介、清水一也、竹垣普惠、西村綾乃、三好真琴、赤城剛、笹井研、堀裕一
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] Gemcitabine Enhances Kras-MEK-induced Matrix Metalloproteinase-10 Expression in Gemcitabine-resistant Pancreatic Tumor-initiating Cells2016
- Author(s)
  Tsuchida Y,Shimizu K, Uenoyama K, Ise Y, Nishiyama S, Hori Y
- Organizer
  第20回 International Association of Pancreatology
- Place of Presentation
  仙台
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] Co-culture with Pancreatic Ductal Adenocarcinoma Cells Converts Acinar Cells to Ductal Phenotype2016
- Author(s)
  Nishiyama S,Shimizu K, Uenoyama K, Ise Y, Tsuchida Y, Hori Y
- Organizer
  第20回 International Association of Pancreatology
- Place of Presentation
  仙台
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] Oncogene-mediated Mouse Pancreatic Progenitor Cells Show Cancer Stem Cell Phenotype2016
- Author(s)
  Ise Y, Shimizu K, Uenoyama K,Nishiyama S, Tsuchida Y, Hori Y
- Organizer
  第20回　International Association of Pancreatology
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26462059
[Presentation] Gemcitabine enhances Kras-MEK-induced matrix metalloproteinase-10 expression via histone acetylation in gemcitabine-resistant pancreatic tumor-initiating cells.2016
- Author(s)
  Tsuchida Y, Shimizu K, Uenoyama K ,Ise Y, Nishiyama S, Hori Y
- Organizer
  第20回　International Association of Pancreatology
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26462059
[Presentation] Co-culture with Pancreatic Ductal Adenocarcinoma Cells Converts Acinar Cells to Ductal Phenotype2016
- Author(s)
  Nishiyama S, Shimizu K, Uenoyama K, Ise Y, Tsuchida Y, Hori Y
- Organizer
  第20回　International Association of Pancreatology
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-26462059
[Presentation] Oncogene-mediated Mouse Pancreatic Progenitor Cells Show Cancer Stem Cell Phenotype2016
- Author(s)
  Ise1 Y, Shimizu K, Uenoyama K, Nishiyama S, Tsuchida, Y, HoriY
- Organizer
  第20回 International Association of Pancreatology
- Place of Presentation
  仙台
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] Oncogene-mediated Mouse Pancreatic Stem Cell Shows Pancreatic Cancer Stem Cell Phenotype2015
- Author(s)
  Nishiyama T, Shimizu K, Uenoyama K, Yamasaki C, Hori Y
- Organizer
  第19回国際膵臓学会
- Place of Presentation
  中国・上海
- Year and Date
  2015-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462059
[Presentation] Pancreatic Ductal Adenocarcinoma Primes the Adjacent Normal Ducts for a Precancerous Phenotype2015
- Author(s)
  Uenoyama K, Shimizu K, Nishiyama T, Yamasaki C, Hori Y
- Organizer
  第19回国際膵臓学会
- Place of Presentation
  中国・上海
- Year and Date
  2015-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462059
[Presentation] nsulin-Producing Cells Derived from the Immortalized Pancreatic Stem Cells2015
- Author(s)
  Yamasaki C, Shimizu K, Uenoyama K, Nishiyama T, Hori Y
- Organizer
  第19回国際膵臓学会
- Place of Presentation
  中国・上海
- Year and Date
  2015-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] Insulin-Producing Cells Derived from the Immortalized Pancreatic Stem Cells2015
- Author(s)
  Yamasaki C, Shimizu K, Uenoyama K, Nishiyama T, Hori Y
- Organizer
  第19回国際膵臓学会
- Place of Presentation
  中国・上海
- Year and Date
  2015-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462059
[Presentation] Oncogene-mediated Mouse Pancreatic Stem Cell Shows Pancreatic Cancer Stem Cell Phenotype2015
- Author(s)
  Nishiyama T, Shimizu K, Uenoyama K, Yamasaki C, Hori Y
- Organizer
  第19回国際膵臓学会
- Place of Presentation
  中国・上海
- Year and Date
  2015-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10183
[Presentation] Gemcitabineが初代膵癌細胞に及ぼす効果の検討 -新規治療薬の開発をめざして-2013
- Author(s)
  藤原範人、清水一也、西山嵩晃、片山南詩、神農祐樹、平井里奈、三浦拓真、上野山恭平、山崎千寛、堀裕一
- Organizer
  第45回日本臨床分子形態学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23592007
[Presentation] Gemcitabineが初代膵癌細胞に及ぼす効果の検討 -新規治療薬の開発をめざして-2013
- Author(s)
  藤原範人、清水一也、西山嵩晃、片山南詩、神農祐樹、平井里奈、三浦拓真、上野山恭平、山崎千寛、堀裕一
- Organizer
  第45回日本臨床分子形態学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24592025
[Presentation] 膵組織幹細胞を用いた再生医療研究2013
- Author(s)
  堀裕一、清水一也、中村幸恵
- Organizer
  第44回日本膵臓学会大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24592025
[Presentation] 膵組織幹細胞を用いた再生医療研究2013
- Author(s)
  堀裕一、清水一也
- Organizer
  第44回日本膵臓学会
- Place of Presentation
  山形
- Year and Date
  2013-07-25
- Data Source
  KAKENHI-PROJECT-23592007
[Presentation] Direct interaction between human pancreatic cancer stem cells and stromal cells remodels extracellular matrix formation for cancer stem cell niche.2012
- Author(s)
  Shimizu K
- Organizer
  10th International Society for Stem Cell Research
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-24592025
[Presentation] Direct interaction between human pancreatic cancer stem cells and stromal cells remodels extracellular matrix formation for cancer stem cell niche2012
- Author(s)
  Shimizu K.
- Organizer
  10^<th> International Society for Stem Cell Research
- Place of Presentation
  横浜
- Year and Date
  2012-06-13
- Data Source
  KAKENHI-PROJECT-23592007
[Presentation] Direct interaction between human pancreatic cancer stem cells and stromal cells remodels extracellular matrix formation for cancer stem cell niche.2012
- Author(s)
  Shimizu K
- Organizer
  10th International Society for Stem Cell Research
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23592007
[Presentation] Direct interaction between human pancreatic cancer stem cells and stromal cells remodels extracellular matrix formation for cancer stem cell niche.2012
- Author(s)
  堀裕一、清水一也、中村幸恵
- Organizer
  American Association for Cancer Research
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-23592007
[Presentation] Direct interaction between pancreatic cancer stem cells and stromal cells remodels extracellular matrix formation for cancer stem cell niche2012
- Author(s)
  Hori Y, Shimizu K.
- Organizer
  103^<rd> American Association for Cancer Research
- Place of Presentation
  Chicago, USA
- Year and Date
  2012-04-01
- Data Source
  KAKENHI-PROJECT-23592007
[Presentation] 膵癌の進展機構における組織幹細胞の関与2012
- Author(s)
  堀裕一、清水一也
- Organizer
  第43回日本膵臓学会
- Place of Presentation
  山形
- Year and Date
  2012-06-28
- Data Source
  KAKENHI-PROJECT-23592007

1. HORI Yuichi (80248004)

# of Collaborated Projects: 9 results

# of Collaborated Products: 79 results
2. 三好真琴 (50433389)

# of Collaborated Projects: 5 results

# of Collaborated Products: 49 results
3. 高井義美 (60093514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 入江賢児 (90232628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 匂坂敏朗 (80359843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 池田わたる (90362699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 扇田久和 (50379236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中西宏之 (80314318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 萬代研二 (50322186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 三好淳 (80166214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 的崎尚 (80252782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 佐々木卓也 (40241278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 味木徹夫 (80379403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shimizu Kazuya 清水 一也

SHIMIZU Kazuya 清水 一也

清水 一也 シミズ カズヤ

Research Projects

Research Products

Co-Researchers

抗がん剤耐性膵臓癌に対するモノアミンオキシダーゼB阻害剤の抗腫瘍効果に関する研究

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Establishment of organoid culture method to reconstruct neural invasion of pancreatic cancer cellsPrincipal Investigator

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The mechanism of promoting remote metastasis by exosome derived from pancreatic cancer

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Pancreatic cancer derived exosomes promote early liver metastasis

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Establishment of novel target therapy for K-ras/MMP-10 signaling pathway in chemotherapy-resistant pancreatic cancerPrincipal Investigator

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Targeting strategy to inhibit liver metastasis for pancreatic cancer

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Reconstruction of pancreatic cancer microenvironmentPrincipal Investigator

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Reconstitution of microenvironment surrounding pancreatic cancer

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Targeting therapy using chemotherapy-resistant pancreatic cancer stem cellsPrincipal Investigator

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細胞間接着による細胞分化の制御機構Principal Investigator

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細胞増殖のシグナリング機構

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[Journal Article] Pancreatic cancer cell-derived exosomes induce epithelial-mesenchymal transition in human pancreatic cancer cells themselves partially via transforming growth factor β12022

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[Journal Article] Xenografts Derived From Patients? Ascites Recapitulate the Gemcitabine Resistance Observed in Pancreatic Cancer Patients2019

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Shimizu Kazuya 清水一也

SHIMIZU Kazuya 清水一也

清水一也シミズカズヤ