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HORIUCHI Seikoh
堀内 正公
Connect your ORCID iD
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Researcher Number
10117377
Other IDs
External Links
Affiliation (based on the past Project Information)
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2004: 熊本大, 教授
2003: 熊本大学, 大学院・医学薬学研究部, 教授
1992 – 2002: 熊本大学, 医学部, 教授
1999: 熊本大学, 医学研究科, 教授
1990 – 1991: 熊本大学, 医学部, 講師
1987 – 1988: 熊本大学, 医学部, 講師
1986: 熊本大, 医学部, 講師
Review Section/Research Field
Principal Investigator
内分泌・代謝学
/
Metabolomics
/
Pathological medical chemistry
/
General medical chemistry
/
Metabolomics
/
Biological Sciences
Except Principal Investigator
内分泌・代謝学
/
老化(加齢)
/
Biological pharmacy
/
Metabolomics
/
Metabolomics
/
Pediatrics
/
Kidney internal medicine
Keywords
Principal Investigator
糖尿病合併症 / マクロファージ / AGE / 泡沫細胞 / スカベンジャー受容体 / 動脈硬化 / AGE受容体 / スカベンジャーレセプター / メイラード反応後期生成物 / 老化現象
…
More
/ グリケーション / RAGE / CD36 / aging / diabetic complications / メイラード反応 / コレステロール逆転送系 / Diabetic Complications / Reverse Cholesterol Transport / 細胞膜レセプター / ノックアウトマウス / リポ蛋白 / アセチルLDL / レセプター介在エンドサイトーシス / 老化 / 糖尿病 / advanced glycation end products (AGE) / scavenger receptor / ACAT / macrophage / 動脈硬化症 / Oxidative stress / Maillard reaction / Atherosclerosis / Galectin-3 / SR-BI / レセプタークローニング / マクロファージ増殖 / 酸化LDL / リゾリン脂質 / 増殖シグナル / HDL / コレステロールエステル選択的輸送系 / ステロイド生産臓器 / カベオリン / コレステロ / ガレクチン / リガンド構造 / GAピリジン / SR-A / アンタゴニスト / メイラード反応後期生成物(AGE) / AGEレセプター / 血管平滑筋細胞 / AGE receptor / macrophages / vascular smooth muscle cells / 糖化反応 / メイラード後期生成物 / AGE(Advanced Glycation End-Products) / 翻訳後蛋白修飾 / 後期反応生成物(AGE) / 主要AGE構造体 / 主要蛍光物質 / 抗AGE特異抗体 / main AGE-structure / fluorescence / crosslinking / posttranslational protein modification / コレステロール代謝 / cDNAクローニング / cholesterol metabolism / foam cells / cDNA cloning / メイラード後期生成物(AGE) / インスリン / PI3 kinase / 細胞内情報伝達系 / インスリン受容体 / lyn / MAP kinase / スカベンジャー受容体(MSR) / インスリン受容体(HIR) / advanced glycation end products (AGF) / insulin / intracellular signal transduction / P13 kinase / insulin receptor / HDL代謝 / Glycation / HDL metabolism / Maillard Reaction endproduct / AGE Receptor / Scavenger Receptor / Maillard Reaction Endproducts / AGE-Receptor / 非酵素的糖付加反応 / メイラー反応 / Nonenzymatic glycosylation / Aging process / Diabetic complications / Receptor
…
More
Except Principal Investigator
動脈硬化 / AGE / マクロファージ / ACAT / CD36 / メイラード反応 / 老化 / 糖尿病 / AGE受容体 / リゾフォスファチジルコリン / 酸化LDL / 血管新生 / Angiogenesis / HIV-1 / N-Myristoylation / Bystander effect / カルボキシメチルリジン / galectin-3 / 泡沫細胞 / コレステロールエステル / macrophage / differentiation / Tetrandrine / VEGF / 変性LDL / NO合成酵素 / Advanced glycation end products (AGE) / グリケーション / 蛍光物質 / 臨床マーカー / ヒト単球遊走活性 / SR-A / RAGE / 糖尿病性血管合併症 / リポ蛋白 / アポ蛋白Aー1含有リポ蛋白 / アポ蛋白AーI含有リポ蛋白 / apoA-I / apoA-II / lipoprotins containing apoA-I / high densitiy lipoprotins / immunoaffinity chromatography / LpA-I / A-II / LCAT / atheroscierosis / reverse cholesterol transport / macrophage foam cells / M-CSF / CETP / コレステロール逆転送系 / SDMF / Rho / VLDL受容体 / VLDL容体 / HDL / 増殖因子 / Small G Protein / 腎臓 / 細胞外マトリックス / 糖化反応最終産物 / 糖尿病性腎症 / 糖化反応 / メサンギウム細胞 / 糸球体 / 血管合併症 / diabetes mellitus / kidney / Maillard reaction / extracellular matrix / 粥状動脈硬化 / 血管内皮細胞 / 血管形成 / 血管平滑筋細胞 / 形質転換 / 接着分子 / LOX-1 / ずり応力 / 酸化LDL受容体 / Atherosclerosis / Vascular endothelial cell / Vasculogenesis / Vascular smooth muscle cell / Phenotypic conversion / Adhesion molecule / Oxidized LDL / HiIV-1 / advanced glycation end products(AGE) / ペントシジン / ガレクチン-3 / アストロサイト / 痴呆 / advanced glycation and products(AGE) / astrocyte / amyloid β protein / Alzheimer's disease / advanced glycation and products / 封入体 / アルツハイマー病 / ピック病 / advanced glycation end products (AGE) / N^<epsilon>- (carboxymethyl) lysine / pentosidine / receptor for AGE / astrocytes / aging / dementia / cholesteryl ester / vesicle / vitamin D / atherosclerosis / foam cells / cholesterol ester / Advanced Glycation End Products / 脈絡膜 / 腫瘍壊死因子-alpha / 血管内皮増殖因子 / Fangchinoline / 腫瘍懐死因子-alpha / Advanced Glycation Endproduct / 網膜 / 糖尿病性網膜症 / THF-α / Advanced Glycation End Product / N^ε-(carboxymethyl)lysine / Choroidal Capillary / Tumor Necrosis Factor-alpha / Nifedipine
Less
Research Projects
(
29
results)
Co-Researchers
(
40
People)
Project Start Year (Newest)
Project Start Year (Oldest)
アディポサイトカインに対する化学修飾蛋白の効果とアディポネクチンの抗動脈硬化作用
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
2004
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Review Section
Biological Sciences
Research Institution
Kumamoto University
AGE受容体のリガンド構造と受容体アンタゴニストの開発
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
2003 – 2004
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Metabolomics
Research Institution
Kumamoto University
ヒト未梢血単球の遊走現象を担う新規AGE受容体の同定と機能分析
Principal Investigator
堺 政和
Project Period (FY)
2003 – 2004
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Metabolomics
Research Institution
Kumamoto University
Roles of CD36 and SR-BI as novel AGE-receptors
Principal Investigator
Principal Investigator
HORIUCHI Seikoh
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Metabolomics
Research Institution
Kumamoto University
Roles of AGE for mechanism of angiogenesis
Principal Investigator
KOBAYASHI Shinjiro
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Biological pharmacy
Research Institution
Hokuriku University
Regulation of ACAT in diabetes and insuliln resistant
Principal Investigator
MIYAZAKI Akira
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Metabolomics
Research Institution
Kumamoto University
分泌型スカベンジャー受容体、ガレクチン3のエンドサイトーシス機能の解析
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
1999
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Metabolomics
Research Institution
Kumamoto University
AGE Structures and their Biomedical Significance
Principal Investigator
Principal Investigator
HORIUCHI Seikoh
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (A).
Research Field
Pathological medical chemistry
Research Institution
Kumamoto University
Role of AGE Receptors in Diabetic Complications
Principal Investigator
Principal Investigator
HORIUCHI Seikoh
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
Metabolomics
Research Institution
Kumamoto University
HDLによる細胞コレステロール搬出系におけるカベオリンの意義
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Metabolomics
Research Institution
Kumamoto University
Regulation of ACAT, an enzyme involved in cholesterol esterification and foam cell formation in vascular walls
Principal Investigator
MIYAZAKI Akira
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Metabolomics
Research Institution
Kumamoto University
コレステロールエステルのステロイド産生臓器への選択的輸送系の細胞遺伝学的解析
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
1997
Research Category
Grant-in-Aid for Exploratory Research
Research Field
内分泌・代謝学
Research Institution
Kumamoto University
Molecular Mechanism of Atherosclerosis
Principal Investigator
KITA Toru
Project Period (FY)
1997 – 2000
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
KYOTO UNIVERSITY
Biological clearance system for advanced glycation end products (AGE) -Insulin signal regulates endocytic uptake of AGE-proteins
Principal Investigator
Principal Investigator
HORIUCHI Seikoh
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
内分泌・代謝学
Research Institution
Kumamoto University
The switch for initiation of tumorigenesis and infectivity of HIV-1 : Protein N-myristoylation
Principal Investigator
SHOJI Shozo
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Biological pharmacy
Research Institution
Kumamoto University
Significance of advanced glycation end products in brain aging
Principal Investigator
KIMURA Takemi
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
老化(加齢)
Research Institution
Kumamoto University
動脈硬化の成因および病態解明に関する総合的研究
Principal Investigator
MATSUZAWA Yuji
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
内分泌・代謝学
Research Institution
Osaka University
メイラード反応後期生成物の主要構造と、老化や糖尿病における生体内発現様式の解析
Principal Investigator
ARAKI Norie
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
老化(加齢)
Research Institution
Kumamoto University
酸化LDLによるマクロファージ増殖機構の解析-特にリゾリン脂質の細胞内情報伝達における役割について
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
1996
Research Category
Grant-in-Aid for Exploratory Research
Research Field
内分泌・代謝学
Research Institution
Kumamoto University
Molecular Biology of Acyl-coenzyme A : cholesterol Acyltransferase
Principal Investigator
Principal Investigator
HORIUCHI Seikoh
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for international Scientific Research
Research Field
Pathological medical chemistry
Research Institution
Kumamoto University
Detemination of The Main Advanced Glycation End Product of The Maillard Reaction and Its Significance as A Biochemical Marker for Diabetic Complications
Principal Investigator
Principal Investigator
HORIUCHI Seikoh
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
内分泌・代謝学
Research Institution
Kumamoto University
Role of advanced glycation end-product in the development and progression of diabetic nephropathy.
Principal Investigator
MAKINO Hirofumi
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Kidney internal medicine
Research Institution
Okayama University
Structure and Function of Receptors for Advanced Glycation End Products of the Maillard Reaction
Principal Investigator
Principal Investigator
HORIUCHI Seikoh
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
General medical chemistry
Research Institution
Kumamoto University
メイラード反応後期生成物に対する細胞膜レセプターの構造と機能
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
1992
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General medical chemistry
Research Institution
Kumamoto University
動脈硬化症の分子生物学的解析と予防・抑制対策に関する総合的研究
Principal Investigator
北 徹
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
内分泌・代謝学
Research Institution
Kyoto University
Function and structure of high density lipoproteins during childhood
Principal Investigator
OHTA Takao
Project Period (FY)
1990 – 1991
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Pediatrics
Research Institution
Kumamoto University
マクロファージによる化学修飾リポ蛋白の認識とコレステロール蓄積機構との相関
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
1987
Research Category
Grant-in-Aid for Special Project Research
Research Institution
Kumamoto University
Non-enzymatic glycosylation of proteins in biological sytem and its physiological significance in aging process.
Principal Investigator
Principal Investigator
HORIUCHI Seikoh
Project Period (FY)
1987 – 1988
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Pathological medical chemistry
Research Institution
Kumamoto University
マクロファージによる化学修飾リポ蛋白の認識とコレステロール蓄積機構との相関
Principal Investigator
Principal Investigator
堀内 正公
Project Period (FY)
1986
Research Category
Grant-in-Aid for Special Project Research
Research Institution
Kumamoto University
# of Projects (Dsc)
# of Projects (Asc)
1.
MIYAZAKI Akira
(70253721)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
2.
MATSUZAWA Yuji
(70116101)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
3.
KITA Toru
(60161460)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
4.
YAMADA Nobuhiro
(40200729)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
5.
斎藤 康
(50101358)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
6.
ARAKI Norie
(80253722)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
HAKAMATA Hideki
(70284750)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
OHTA Takao
(70185271)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
堺 政和
(40346979)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
高橋 潔
(70045631)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
MAEDA Kenji
(90023853)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
MAKINO Hirofumi
(50165685)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
SHIKATA Kenichi
(00243452)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
ANDO Joji
(20159528)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
MARUYAMA Ikuro
(20082282)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
ARAKI Eiichi
(10253733)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
SHOJI Shozo
(60040317)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
TAKAHASHI Ichiro
(40091045)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
MISUMI Shogo
(40264311)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
FURUISHI Kazuchika
(40238663)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
KIMURA Takemi
(50284766)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
MIYAKAWA Taihei
(90040542)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
NAGAI Ryoji
(20315295)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
TAKEYA Motohiro
(90155052)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
KOBAYASHI Shinjiro
(10186744)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
横山 光宏
(40135794)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
池田 康夫
(00110883)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
池田 剛
(80295138)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
山本 徳男
(30192412)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
高井 義美
(60093514)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
IENAGA Kazuharu
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
YAMAJI Hiroaki
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
CHANG Ta-Yuan
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
KOIKE Hiroyuki
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
CHANG TaーYua
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
PAUL J.Thorn
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
BARD Smedsro
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
JOHN W.Bayne
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
39.
VINCENT M. M
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
40.
HAGINO Nobuyoshi
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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