HOTTA Katsuyuki 堀田勝幸

… Alternative Names

堀田勝幸ホッタカツユキ

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Researcher Number	70379816
Other IDs
Affiliation (Current)	2025: 岡山大学, 医療開発領域, 教授
Affiliation (based on the past Project Information) *help	2015 – 2023: 岡山大学, 大学病院, 教授 2014: 岡山大学, 大学病院, 講師 2013 – 2014: 岡山大学, 大学病院, 助教 2008: 岡山大, 助教 2007: Okayama University, 保健環境センター, 助教 2006: 岡山大学, 保健環境センター, 助手
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Public health/Health science Except Principal Investigator Basic Section 90140:Medical technology assessment-related / Basic Section 90130:Medical systems-related / Respiratory organ internal medicine
Keywords	Principal Investigator EGFR-TKI / 肺癌 / EGFR肺癌 / EGFR変異陽性肺癌 / EGFR遺伝子変異陽性肺癌 / インターロイキン6（IL-6） / EGFR遺伝子変異陽性非小細胞肺がん / チロシンキナーゼ阻害薬 / IL-6 / EGFR … More / クォンティフェロン検査 / 結核健診 / 医療系大学生 / ツベルクリン反応検査 / 結核検診 / クォンティフェロン … More Except Principal Investigator データマネジメント / 薬事承認申請 / 品質マネジメント / 先進医療 / 特定臨床研究 / 臨床研究法 / 悪性腫瘍 / 予防医学 / 遺伝子検査学 / 臨床検査システム / 固形癌 / メチル化 / エピゲノム / 先制医療 / 生体情報・計測 / 腫瘍検査学 / 検査・診断システム / mTOR阻害薬 / BIBW2552 / JAK1/2阻害薬 / everolimus / ｍTOR阻害薬 / 遺伝子改変マウス / 用量依存性 / gefitinib / AZD1480 / everolims / EGFR / NNK / Ogg1ホモノックアウトマウス / bevacizumab / cetuximab / JAK-1/2 inhibitors / everolimus (mTOR阻害薬), / afatinib / EGFR遺伝子改変マウス Less

EGFR肺癌における第3世代EGFR-TKI耐性へのIL-6の関与と克服の検討Principal Investigator
- Principal Investigator
  
  堀田勝幸
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Okayama University
Quality management of Advanced medical care clinical resarch under Clinical Trial Act for pharmaceutial approval application
- Principal Investigator
  
  Sakurai Jun
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  Okayama University
Preemptive Medicine to Solid Tumors based on Epigenomics
- Principal Investigator
  
  NAGASAKA TAKESHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Kawasaki Medical School
Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutationsPrincipal Investigator
- Principal Investigator
  
  Hotta Katsuyuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Okayama University
Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse
- Principal Investigator
  
  KIURA Katsuyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
医療系大学生に対するクォンティフェロン検査を用いた結核対策の精度向上に関する検討Principal Investigator
- Principal Investigator
  
  堀田勝幸
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Public health/Health science
- Research Institution
  Okayama University

All 2018 2015 2014 2013 2012 2011 2007

All Journal Article Presentation

[Journal Article] Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations.2018
- Author(s)
  Tamura T, Kato Y, Ohashi K, Ninomiya K, Makimoto G, Gotoda H, Kubo T, Ichihara E, Tanaka T, Ichimura K, Maeda Y, Hotta K, Kiura K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 495 Issue: 1 Pages: 360-367
- DOI
  10.1016/j.bbrc.2017.10.175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19454, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-26430163, KAKENHI-PROJECT-16K15458
[Journal Article] Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer.2014
- Author(s)
  Ochi N, Takigawa N, Harada D, Yasugi M, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 322 Issue: 1 Pages: 168-177
- DOI
  10.1016/j.yexcr.2014.01.007
- NAID
  120005517858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene.2014
- Author(s)
  Isozaki H, Yasugi M, Takigawa N, Hotta K, Ichihara E, Taniguchi A, Toyooka S, Hashida S, Sendo T, Tanimoto M, Kiura K.
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 2014 Issue: 10 Pages: 963-968
- DOI
  10.1093/jjco/hyu110
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors.2014
- Author(s)
  Yasugi M, Takigawa N, Ochi N, Ohashi K, Harada D, Ninomiya T, Murakami T, Honda Y, Ichihara E, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 326 Issue: 2 Pages: 201-209
- DOI
  10.1016/j.yexcr.2014.04.012
- NAID
  120005526613
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.2013
- Author(s)
  Takeda H, Takigawa N, Ohashi K, Minami D, Kataoka I, Ichihara E, Ochi N, Tanimoto M, Kiura K.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 319 Issue: 2 Pages: 417-423
- DOI
  10.1158/1541-7786.mcr-12-0401
- NAID
  120005359097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-23651046, KAKENHI-PROJECT-24310042, KAKENHI-PLANNED-23114010
[Journal Article] Impact of physical size on gefitinib efficacy in patients with non-small cell lung cancer harboring EGFR mutations.2013
- Author(s)
  Ichihara E, Hotta K, Takigawa N, Kudo K, Kato Y, Honda Y, Hayakawa H, Minami D, Sato A, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Lung Cancer.
  
  Volume: 81 Issue: 3 Pages: 435-439
- DOI
  10.1016/j.lungcan.2013.05.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Establishment of pemetrexed-resistant non-small cell lung cancer cell lines2011
- Author(s)
  Zhang D, Ochi N, Takigawa N, Tanimoto I, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K
- Journal Title
  
  Cancer Lett
  
  Volume: 309 Issue: 2 Pages: 228-235
- DOI
  10.1016/j.canlet.2011.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Whole Blood Interferon-gamma Assay for Baseline Tuberculosis Screening among Japanese Healthcare Students2007
- Author(s)
  Hotta K, et. al.
- Journal Title
  
  Plos One 2(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790397
[Presentation] Interleukin-6 Is a Valuable Predictive Marker for Therapeutic Effect of Gefitinib in Patients with Advanced NSCLC Harboring EGFR Mutations2015
- Author(s)
  Y. Kato, K. Hotta, T. Tamura, T. Tanaka, K. Ichimura, K. Ohashi, T. Kubo, E. Ichihara, M. Tanimoto, K. Kiura
- Organizer
  第16回世界肺癌会議
- Place of Presentation
  米国コロラド州デンバー
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430163
[Presentation] ALK inactivation induced acquired resistance to alectinib in lung cancer harboring EML4-ALK fusion gene.2014
- Author(s)
  Hideko Isozaki, Eiki Ichihara, Masayuki Yasugi, Ocihi Nobuaki, Katsuyuki Hotta, Nagio Takigawa, Toshiaki Sendo, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  The 105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, CA. USA
- Year and Date
  2014-04-08
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Afatinib prolonged survival in EGFR-driven lung cancer model compared to gefitinib2012
- Author(s)
  Takashi Ninomiya, Eiki Ichihara, Akiko Hisamoto, Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura, Nagio Takigawa, Nobuaki Ochi, Masayuki Yasugi, Daijiro Harada.
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  McCormick Place in Chicago, Illinois
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Effect of AZD1480 on lung tumor in transgenic mice carrying activating EGFR mutation2012
- Author(s)
  Toshi Murakami, Nagio Takigawa, Takashi Ninomiya, Nobuhiro Honda, Hideko Isozaki, Eiki Ichihara, Akiko Hisamoto, Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  McCormick Place in Chicago, Illinois
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Role of ERK reactivation mediated by Src in acquired resistance to gefitinib in non-small cell lung cancer with EGFR mutation2011
- Author(s)
  Ochi N, Takigawa N, Ohashi K, Takeda H, Fujii M, Kubo T, Ichihara E, Hotta K, Tanimoto M, Kiura K
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orange County Convention Center, Orlando, FL, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] 医療系大学生に対するクォンティフェロン検査(QFT)を用いた結核対策の精度向2007
- Author(s)
  堀田勝幸、他
- Organizer
  第42回日本呼吸器学会中国四国地方会
- Place of Presentation
  広島
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-18790397
[Presentation] 医療系大学生に対するクォンティフェロン検査(QFT)を用いた結核対策の精度向2007
- Author(s)
  堀田勝幸、他
- Organizer
  第45回全国大学保健管理研究集会
- Place of Presentation
  別府
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-18790397

1. KIURA Katsuyuki (10243502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. 加藤有加 (50544904)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. TKIGAWA Nagio (60325107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. TAKATA Minoru (30281728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKABEPPU Yusaku (30180350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YOSHINO Tadashi (70183704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAGASAKA TAKESHI (30452569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Sakurai Jun (30444657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 市原英基 (40549705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. 山口佳之 (10230377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 楳田祐三 (10573735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 堅田洋佑 (20716881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 西田直生志 (60281755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 母里淑子 (70708081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 四方賢一 (00243452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大野彩 (20584626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Tamura Tomoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. Ninomiya Kiichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Ohashi Kadoaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. Makimoto Go

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOTTA Katsuyuki 堀田 勝幸

堀田 勝幸 ホッタ カツユキ

Research Projects

Research Products

Co-Researchers

EGFR肺癌における第3世代EGFR-TKI耐性へのIL-6の関与と克服の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Quality management of Advanced medical care clinical resarch under Clinical Trial Act for pharmaceutial approval application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Preemptive Medicine to Solid Tumors based on Epigenomics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

医療系大学生に対するクォンティフェロン検査を用いた結核対策の精度向上に関する検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer.2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors.2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Impact of physical size on gefitinib efficacy in patients with non-small cell lung cancer harboring EGFR mutations.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of pemetrexed-resistant non-small cell lung cancer cell lines2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Whole Blood Interferon-gamma Assay for Baseline Tuberculosis Screening among Japanese Healthcare Students2007

HOTTA Katsuyuki 堀田勝幸

堀田勝幸ホッタカツユキ