YOKOI Tsuyoshi 横井毅

Researcher Number	70135226
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016 – 2021: 名古屋大学, 医学系研究科, 教授 2013 – 2015: 名古屋大学, 医学(系)研究科(研究院), 教授 2008 – 2012: Kanazawa University, 薬学系, 教授 2008: 金沢大学, 大学院・自然科学研究科, 教授 2002 – 2007: 金沢大学, 医学系研究科, 教授 … More 1997 – 2002: 金沢大学, 薬学部, 教授 2001: 金沢大学, 医学研究科, 教授 1990 – 1996: 北海道大学, 薬学部, 助教授 1991: Univ. of Hokkaido, Dep. of Pharmac., Associate Professor, 薬学部・分析化学, 助教授 1990: 北海道大学, 薬学部・分析, 助教授 1989: 東北大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological pharmacy / Applied pharmacology / 応用薬理学・医療系薬学 / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Biological pharmacy / Legal medicine / General surgery / 医薬分子機能学 / General surgery / Physical pharmacy / Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator マイクロRNA / 薬物性肝障害 / バイオマーカー / CYP2A6 / チトクロムP450 / 薬物誘導性肝障害 / トログリタゾン / プロテインジスルフィドイソメラーゼ / カルレチクリン / LECラット … More / 自己免疫性抗体 / 肝炎 / miR-148a / CYP3A4 / チトクロームP450 / microRNA / ハロタン / 医薬品副作用 / カルバマゼピン / 代謝的活性化 / 動物モデル / 遺伝子診断 / SM-12502 / polymorphism / population study / poor metabolizer / genotyping / troglitazone / 医薬品開発 / チトクロ-ムPー450 / エンケファリン / 合成ペプチド / ロイシンーエンケファリン / メチオニンーエンケファリン / miR-27b / miR-125b / miR-378 / PXR / CYP1B1 / CYP24 / miR-22 / 細胞毒性 / 個人差 / Pregnane X receptor / 転写後調節 / ヒト肝細胞 / 転写因子 / 肝細胞障害モデル動物 / ヒト肝障害患者血清 / 末梢血microRNA / ターゲットタンパク質 / ヘルパーT細胞 / 肝細胞障害モデルラット / 胆汁うっ滞モデルラット / ヒト間葉系幹細胞 / ヒトアルブミン / CYP3A4酵素活性 / 分化誘導 / 薬物相互作用 / hypersensitivity / 皮膚障害 / フェニトイン / 薬物過敏症 / 薬物アレルギー / 免疫学的因子 / 反応性代謝物 / グルクロン酸転移酵素 / アシルグルクロニド / ジクロフェナク / ゾメピラク / 加水分解酵素阻害薬 / グルタチオン合成阻害薬 / 加水分解酵素 / アシルグルクロナイド / UGT1A3 / UGT2B7 / アルコール性肝障害 / Autoimmune antibodies / LEC rats / Hepatitis / Protein disulfide isomerase / Cyclosporin-A / D-Penicillamine / クマリン / poor mtabolizer / チトクロームP450 2D6 / チトクロームP450 2A6 / drugmetabolism / 発がん / CYP2D6 / CYP1A2 / coumarin / HITECマウス / ポリフェノール / エビガロカテキンガレート / ベンツ[a]ピレン / 突然変異検出 / 化学発癌 / 遺伝子損傷 / エピガロカテキンガレート / epigallocatechin gallate / benzo[a]pyrene / mutagenesis / antimutagenesis / HITEC mouse / rpsL gene / 薬物代謝酵素 / SNPs / ニコチン / トランスポーター / 人種差 / 肝障害 / キノン体代謝物 / drug metabolizing enzyme / cytochrome P450 / Nicotine / transporter / Phenotyping / DNAマイクロアレイ / 毒性予測 / アセトアミノフェン / チオアセタミド / QTクラスタリング / 四塩化炭素 / アルドラーゼB / 自己抗体 / 肝毒性 / ラット / クラスタリング解析 / DNAチップ / ジエチルニトロソアミン / DNA microarray / drug induced hepatotoxicity / prediction / QT clastering / acetaminophen / 薬物性肝障害、 / 個体差 / 抗てんかん薬 / 薬剤性肝障害 / 代謝多型 / 代謝多型血 / 肝障害予測 / 特異体質性肝障害 / 肝類洞内皮細胞 / 薬物性腎障害 / 毒性発現機序解析 / 毒性発現予測試験系 / グルタチオン / ラモトリギン / エナラプリル / in vitro cell-based スクリーニング / 酸化ストレス / 毒性発現機序 / 血中マイクロRNA / 薬剤反応性 / 薬学 / 細胞・組織 / エクソゾーム / 特異体質性薬物性肝障害 / 動物病態モデル / 肝障害発症機序 / 炎症免疫因子 / 特異体質性 / 発症機序 / 前臨床医薬品開発 / 胆汁うっ滞性肝障害 / エクソソーム / 免疫因子 / 非実質細胞 … More Except Principal Investigator P450 / チトクロームP450 / PCR / P-450IIIA / アフラトキシンB_1 / チトクロームP-450 / Nuclear polyhedorosis virus / Poor metabolizer / CYP1A2 / CYP2D6 / CYP2C / 薬物代謝酵素 / CYP / トランスジェニックマウス / バキュロウイルス発現系 / 大量発現系 / CYP3A7 / p21 / ハプトグロビン / ハプトグロビンcDNAプロ-ブ / 血痕検査 / HP^o型 / パーキンソン病 / FMO / MPTP / TIQ / cDNAクローニング / 人工臓器学 / ヒトES細胞 / 細胞・組織 / 再生医学 / 移植・再生医療 / バイオテクノロジー / 国際情報交換 / アメリカ / 遺伝的多型 / プロ-ブ / 血痕 / 親子鑑定 / DNA Fingerprint法 / 血清蛋白型 / 個人識別 / DNA多型 / pHYN22 / MCT118 / VNTR / GStπ gene / ORM型 / Factor1 / 唾液アミラ-ゼ / フィンガ-プリント法 / PCR法 / 蛋白多型 / 人獣鑑定 / 性別鑑定 / RFLP_S / DNA / 赤血球酵素 / 血清蛋白 / Genetic polymorphism / Probe / Blood stain / Paternity testing / DNA fingerprinting / Serum protein / Individual identification / 胎児 / 肝臓 / SRalphaプロモーター / デキサメタゾン / チトクロムPー450 / Pー450IIIA / SF9細胞 / nuclear polyhedorosis virus / umu試験 / 薬物代謝 / チトクロ-ムPー450 / ヒト胎児肝 / 細胞毒性試験 / 転写調節機構 / MCFー7 / Pー450HFLa / Pー450_<NF> / Fetus / Liver / Aflatoxin B_1 / SRalpha promoter / Dexamethasone / Cytochrome P-450 / カフェイン / N-アセチル転移酵素 / 多型性 / チトクローム P450 / poor metabolizer / S-メフェニトイン / P-450IID6 / P-450IIC / 遺伝的多型性 / P-450IA2 / eytensive metabolizer / Cytochrome P450 / Caffeine / N-acetyltransferase / Polymorphism / 胎児特異的 / 代謝的活性化 / 発現調節 / fetus-specific / transgenicmouse / bioactivation / 代替法 / p53欠損マウス / 細胞発現系 / 肝細胞 / p53欠失マウス / N-アセチルトランスフェラーゼ / in vitro 毒性試験 / Alternatives / Transgenic mouse / p53-Knockout mouse / Cell expression system / Hepatocyte / ヒト肝ミクロゾーム / フェニトイン / テガフール / 個人差 / P450組成比 / 共発現系 / 薬物相互作用 / チトクロムP450 / CYP3A4 / 組換えヒトP450 / NADPH-P450還元酵素 / チトクロームb5 / 大腸菌 / テストステロン / human liver microsomes / phenytoin / tegafur / Individual difference / P450 contents / coexpressing system / drug Interaction / 可逆性不死化 / ヒト肝細胞株 / ヒト肝内皮細胞株 / バイオ人工肝臓 / ブタ肝細胞分離 / 不死化肝細胞 / テロメレース / ブタ肝不全 / reversible immortalization / human hepatocyte cell line / human liver endothelial cell line / bioartificial liver / porcine hepatocyte isolation / 多環芳香族炭化水素 / ディーゼル排出粉塵 / アンドロゲン様 / 抗アンドロゲン活性 / モノヒドロキシ多環芳香族炭化水素 / 酵母two-hybrid法 / 蛍光検出逆相HPLC / 尿 / 喫煙 / 4-ヒドロキシベンツ[a]アントラセン / エストロゲン様 / 抗エストロゲン活性 / モノヒドロキシ体 / polycyclic aromatic hydrocarbon / diesel exhaust particulate / androgen / antiandrogen activity / monohydroxylated polycyclic aromatic hydrocarbon / east two-hybrid assay / HPLC / fluoresecnce detection / urine / smoking / 肝線維化 / lncRNA / エクソソーム / 肝障害 / non-coding RNA / microRNA / 肝星細胞 / 長鎖非コードRNA Less

Comprehensive functional analysis of lncRNAs in liver fibrosis
- Principal Investigator
  
  織田進吾
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Nagoya University
特異体質性薬物性肝障害発症の個体差の決定因子の解明と予測試験系の開発Principal Investigator
- Principal Investigator
  
  横井毅
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya University
Establishment of a predictive test system for idiosyncratic drug-induced liver injury and study for evaluation of onset biomarkersPrincipal Investigator
- Principal Investigator
  
  Yokoi Tsuyoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya University
Factors of individual variability in onset of drug-induced liver injuryPrincipal Investigator
- Principal Investigator
  
  Yokoi Tsuyoshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya University
Risk assessment and mechanistic analysis of adverse reactions of the acyl glucuronides.Principal Investigator
- Principal Investigator
  
  Yokoi Tsuyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya University
Establishment of drug hypersensitivity animal model and investigation of the mechanism.Principal Investigator
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya University
  Kanazawa University
ヒト組織適合性抗原遺伝多型に相関して発症する特異体質性薬物性肝障害の予測系の構築Principal Investigator
- Principal Investigator
  
  横井毅
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
ヒト間葉系幹細胞からの肝細胞様細胞の作成と薬物動態毒性学的評価研究Principal Investigator
- Principal Investigator
  
  横井毅
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
MicroRNAs as biomarkers for drug-induced liver injuryPrincipal Investigator
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kanazawa University
Hepatic differentiation of human embryonic stem cells and its application to the development of a bioartificial liver system
- Principal Investigator
  
  TANAKA Noriaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Okayama University
ヒト初代培養肝細胞におけるマイクロRNAの役割Principal Investigator
- Principal Investigator
  
  横井毅
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Role of microRNA on drug-induced hepatotoxocityPrincipal Investigator
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Studies to develop the prediction system for drug metabolism, pharmacokineties and toxicity.Principal Investigator
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kanazawa University
Study on Endocrine Disruption of Polycyclic Aromatic Hydrocarbons and Their Metabolites and Its Assay
- Principal Investigator
  
  HAYAKAWA Kazuichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Bioartificial liver development using reversibly immortalized human liver cell lines.
- Principal Investigator
  
  TANAKA Noriaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Okayama University
Investigation and evaluation of genetic polymorphisms of drug metabolizingPrincipal Investigator
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kanazawa University
PREDICTION OF DRUG DISPOSITION BY HUMAN DRUG METABOLIZING ENZYMES
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  KANAZAWA UNIVERSITY
Evaluation of the antimutagenic effect of (-)-epegallocatechin gallate (EGCG) against chemical-induced mutagenesis of transgenic HITEC micePrincipal Investigator
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kanazawa University
Pharmacogenetics of drug metabolizing enzymesPrincipal Investigator
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Analysis of human fetus-specific cytochrome P450 : Evaluation of its function (s) by using transgenic mice and estimation of regulation mechnism (S).
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
DEVELOPMENT OF NOVEL ALTERNATIVE METHODS FOR THE PREDICTION OF DRUG METABOLISM IN HUMANS
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
パーキンソン病の原因解明:脳内におけるMPTP及びその類似化合物の代謝を司る酵素系の同定及びcDNAクローニング
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Can the Occurence of Autoantibody to Protein Disulfide Isomerase be a Marker for the Development of Hepatitis?Principal Investigator
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
特異自己免疫抗体の出現は劇症肝炎発生の原因か?肝炎自然発症(LEC)ラットをモデルとしてPrincipal Investigator
- Principal Investigator
  
  横井毅
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
チトクロ-ムPー450の新しい生理的意義に関する研究ー内因性生理活性ペプチドの調節における役割ーPrincipal Investigator
- Principal Investigator
  
  横井毅
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
System for the regulation of in vivo drug concentration ; Analyzes of genetic polymorphisms of drug metabolizing enzymes
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Basic study for dunction and gene regulation of human fetal liver P-450
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
ハプトグロビン特異的DNAの多型性.検出とその法医学的応用およびHp^o型との関連
- Principal Investigator
  
  勾坂薫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tohoku University
Application of New Genetic Markers on Proteins, Enzymes and DNA to Forensic Medicine.
- Principal Investigator
  
  HARADA Shoji
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Legal medicine
- Research Institution
  University of Tsukuba

[Book] 日本薬理学会雑誌2014
- Author(s)
  横井　毅
- Publisher
  日本薬理学会
- Data Source
  KAKENHI-PROJECT-24659073
[Book] 月刊薬事2014
- Author(s)
  横井　毅
- Total Pages
  195
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-24659073
[Book] 月刊薬事2014
- Author(s)
  横井　毅
- Total Pages
  195
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-25293037
[Book] 日本薬理学雑誌2014
- Author(s)
  横井　毅
- Publisher
  日本薬理学会
- Data Source
  KAKENHI-PROJECT-25293037
[Book] Ann. Rev. Pharmacol. Toxicol.2013
- Author(s)
  Tsuyoshi Yokoi and Miki Nakajima.
- Total Pages
  24
- Publisher
  Annual Reviews, A Nonprofit Scholarly Publisher
- Data Source
  KAKENHI-PROJECT-24659073
[Book] 薬物代謝反応・代謝酵素の多様性と薬物相互作用の予測, 「In vitro毒性・動態評価の最前線」小島肇監修2013
- Author(s)
  横井毅
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-24659073
[Book] 医薬品開発に必要なストラテジー上2011
- Author(s)
  横井毅
- Total Pages
  310
- Publisher
  金芳堂(日本薬理学会編)分担
- Data Source
  KAKENHI-PROJECT-21390174
[Book] 薬物代謝に関与する酵素とその反応機構,薬物代謝と毒性発現「薬物代謝学医療薬学・医薬品開発の基礎として第3版」2010
- Author(s)
  横井毅
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-21390174
[Book] Troglitazone. Adverse Drug Reactions. In Handbook of Experimental Pharmacology 1962010
- Author(s)
  Tsuyoshi Yokoi
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-21390174
[Book] 薬物代謝学(加藤隆一、山添康、横井毅編集)2010
- Author(s)
  横井毅
- Total Pages
  250
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-22659031
[Book] 薬物代謝学(加藤隆一、山添康、横井毅編集)2010
- Author(s)
  横井毅
- Total Pages
  250
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-21390174
[Book] Mechanism of Adverse Drug Reaction (共著)2009
- Author(s)
  Tsuyoshi Yokoi(in press)
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18390049
[Book] In Hepatotoxicity : From Genomics to in vitro and in vivo2007
- Author(s)
  Rawiwan Maniratanachote, and Tsuyoshi Yokoi : Amechanistic view of troglitazone hepatotoxicity
- Publisher
  S.C. Sahu Ed. John Wiley & Sons, Ltd. Pp
- Data Source
  KAKENHI-PROJECT-18390049
[Book] A mechanistic view of troglitazone hepatotoxicity.2007
- Author(s)
  Rawiwan Maniratanachote, and Tsuyoshi Yokoi
- Total Pages
  682
- Publisher
  John Wiley & Sons, Ltd
- Data Source
  KAKENHI-PROJECT-18390049
[Book] In Mechanism of Adverse Drug Reaction, Handbook of Expreimental Pharmacology, Springer
- Author(s)
  Tsuyoshi Yokoi : Troglitazone
- Publisher
  J. Uetrecht (in press)
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Plasma miR-218a-5p as a biomarker for acute cholestatic liver injury in rats and investigation of its pathophysiological roles.2021
- Author(s)
  Shingo Oda, Yuka Hirabuki, Taiki Takeuchi, Takumi Kagawa, and Tsuyoshi Yokoi.
- Journal Title
  
  Journal of Applied Toxicology
  
  Volume: in press
- DOI
  10.1002/jat.4144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03388
[Journal Article] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury2021
- Author(s)
  Shingo Oda, Yuka Uchida, Michael D. Aleo, Petra H. Koza-Taylor, Yusuke Matsui, Masanori Hizue, Lisa D. Marroquin, Jessica Whritenour, Eri Uchida, and Tsuyoshi Yokoi.
- Journal Title
  
  Archives of Toxicology
  
  Volume: in press Pages: 149-168
- DOI
  10.1007/s00204-020-02882-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03388, KAKENHI-PROJECT-18H03207
[Journal Article] Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production.2020
- Author(s)
  Reo Kawata, Shingo Oda, Yoshihiro Koya, Hiroaki Kajiyama, and Tsuyoshi Yokoi.
- Journal Title
  
  Toxicology
  
  Volume: 443 Pages: 152544-152544
- DOI
  10.1016/j.tox.2020.152544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03388
[Journal Article] Exacerbation of gefitinib-induced liver injury by glutathione reduction in mice.2020
- Author(s)
  Shingo Oda, Nanaka Miyazaki, Koichi Tsuneyama, and Tsuyoshi Yokoi.
- Journal Title
  
  Jouranal of Toxicological Sciences
  
  Volume: 45 Pages: 493-502
- NAID
  130007884274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03388
[Journal Article] Exacerbation of gefitinib-induced liver injury by glutathione reduction in mice2020
- Author(s)
  Oda Shingo、Miyazaki Nanaka、Tsuneyama Koichi、Yokoi Tsuyoshi
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 45 Issue: 8 Pages: 493-502
- DOI
  10.2131/jts.45.493
- NAID
  130007884274
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-19K07099
[Journal Article] Pharmacological evidence for the involvement of ryanodine receptors in halothane-induced liver injury in mice.2020
- Author(s)
  Ru Jia, Shingo Oda, and Tsuyoshi Yokoi.
- Journal Title
  
  Toxicology
  
  Volume: 443 Pages: 152560-152560
- DOI
  10.1016/j.tox.2020.152560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03388
[Journal Article] Strain and interindividual differences in lamotrigine-induced liver injury in mice.2019
- Author(s)
  Sho Akai, Shingo Oda, and Tsuyoshi Yokoi.
- Journal Title
  
  Journal of Applied Toxicology
  
  Volume: 39 Pages: 451-460
- DOI
  10.1002/jat.3736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03388
[Journal Article] Establishment of a novel mouse model of troglitazone-induced liver injury and analysis of its hepatotoxic mechanism.2019
- Author(s)
  Jia Ru、Oda Shingo、Tsuneyama Koichi、Urano Yuya、Yokoi Tsuyoshi
- Journal Title
  
  Journal of Applied Toxicology
  
  Volume: 39 Pages: 1541-1556
- DOI
  10.1002/jat.3838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-19H03388
[Journal Article] Experimental evidence of liver injury by BSEP inhibiting drug with a bile salt supplementation in rats.2019
- Author(s)
  Fuhua Yang, Shingo Oda, Taiki Takeuchi, Koichi Tsuneyama, and Tsuyoshi Yokoi.
- Journal Title
  
  Toxicological Sciences
  
  Volume: 170 Pages: 95-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03388
[Journal Article] Comprehensive analysis of serum microRNAs in hapatic sinusoidal obstruction syndrome (SOS) in rats: implication as early-phase biomarkers for SOS.2018
- Author(s)
  Takeuchi Masaki、Oda Shingo、Tsuneyama Koichi、Yokoi Tsuyoshi
- Journal Title
  
  Arch. Toxicol.
  
  Volume: 92 Pages: 2947-2962
- DOI
  10.1007/s00204-018-2269-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-16H02616
[Journal Article] Comprehensive hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice.2018
- Author(s)
  Urano Yuya、Oda Shingo、Tsuneyama Koichi、Yokoi Tsuyoshi
- Journal Title
  
  Chem. Biol. Interact.
  
  Volume: 296 Pages: 185-197
- DOI
  10.1016/j.cbi.2018.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-16H02616
[Journal Article] Identification of specific microRNA biomarkers in early stage of hepatocellular injury, cholestasis, and steatosis in rat.2018
- Author(s)
  Takumi Kagawa, Yuji Shirai, Shingo Oda and Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. Sci.
  
  Volume: 166 Pages: 228-239
- DOI
  10.1093/toxsci/kfy200
- NAID
  130007432275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02616
[Journal Article] Role of cytochrome P450-mediated metabolism and involvement of reactive metabolite formations on antiepileptic drug-induced liver injuries2018
- Author(s)
  1)Eita Sasaki, and Tsuyoshi Yokoi
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 43 Issue: 2 Pages: 75-87
- DOI
  10.2131/jts.43.75
- NAID
  130006404126
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02616
[Journal Article] MicroRNA in rat liver sinusoidal endothelial cells and hepatocytes and application to circulating biomarkers that discern pathogenesis of liver injuries.2018
- Author(s)
  Shingo Oda, Masaki Takeuchi, Sho Akai, Yuji Shirai, Koichi Tsuneyama, and Tsuyoshi Yokoi
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 188 Pages: 916-928
- DOI
  10.1016/j.ajpath.2017.12.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02616
[Journal Article] Cell-based assay using glutathione-depleted HepaRG human liver cells for predicting drug-induced liver injury.2018
- Author(s)
  Jieyu Xu, Shingo Oda and Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. In Vitro
  
  Volume: 48 Pages: 286-301
- DOI
  10.1016/j.tiv.2018.01.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02616
[Journal Article] Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice2017
- Author(s)
  Oda S, Shirai Y, Akai S, Nakajima A, Tsuneyama K, Yokoi T.
- Journal Title
  
  J. Appl. Toxicol.
  
  Volume: 37 Pages: 545-553
- DOI
  10.1002/jat.3388
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15098, KAKENHI-PROJECT-15K21057, KAKENHI-PROJECT-16H02616
[Journal Article] A modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk.2017
- Author(s)
  Takafumi Tomida, Hayao Okamura, Tsuyoshi Yokoi, Yoshihiro Konno.
- Journal Title
  
  Journal of Applied Toxicology
  
  Volume: 37 Pages: 382-390
- DOI
  10.1002/jat.3371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02616
[Journal Article] Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steratohepatitis, or drug-induced liver injury.2017
- Author(s)
  Yu Yamaura, Naoyuki Tatsumi, Shingo Takagi, Shinsaku Tokumitsu, Tatsuki Fukami, Kazuto Tajiri, Masami Minemura, Tsuyoshi Yokoi and Miki Nkajima.
- Journal Title
  
  Clinical Biochemistry
  
  Volume: 50 Pages: 1034-1039
- DOI
  10.1016/j.clinbiochem.2017.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02616
[Journal Article] Estabolishment of a novel mouse model for pioglitazone-mediated skeletal muscle injuty.2017
- Author(s)
  Sho Akai, Shingo Oda and Tsuyoshi Yokoi
- Journal Title
  
  Toxicology
  
  Volume: 382 Pages: 1-9
- DOI
  10.1016/j.tox.2017.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02616
[Journal Article] Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis2017
- Author(s)
  Shirai Y, Oda S, Makino S, Tsuneyama K, Yokoi T.
- Journal Title
  
  Lab. Invest.
  
  Volume: in press Pages: 545-553
- DOI
  10.1038/labinvest.2017.22
- NAID
  130006582043
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15098, KAKENHI-PROJECT-15K21057, KAKENHI-PROJECT-16H02616
[Journal Article] Pathogenetic analyses of carbamazepine-induced liver injury in F344 rats focused on immune- and inflammation-related factors.2016
- Author(s)
  Eita Sasaki, Azumi Iida, Shingo Oda, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakaima, and Tsuyoshi Yokoi
- Journal Title
  
  Exp Toxicol Pathol.
  
  Volume: 68 Pages: 27-38
- DOI
  10.1016/j.etp.2015.09.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15001, KAKENHI-PROJECT-15K15098, KAKENHI-PROJECT-25293037
[Journal Article] Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats.2016
- Author(s)
  Akai S, Uematsu Y, Tsuneyama K, Oda S, Yokoi T.
- Journal Title
  
  J. Appl. Toxicol
  
  Volume: 36 Pages: 702-705
- DOI
  10.1002/jat.3202
- NAID
  130005483633
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15098, KAKENHI-PROJECT-25293037, KAKENHI-PROJECT-15K15001
[Journal Article] Micro RNA-mediated Th2 bias in the pathogenesis of methimazole-induced acute liver injury in mice.2016
- Author(s)
  Yasuaki Uematsu, Sho Akai, Tomoaki Tochitani, Shingo Oda, Toru Yamada, Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. Appl. Pharmacol.
  
  Volume: 07 Pages: 1-9
- DOI
  10.1016/j.taap.2016.07.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K21057, KAKENHI-PROJECT-15K15001
[Journal Article] Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism.2016
- Author(s)
  Shohei Takai, Shingo Oda, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi.
- Journal Title
  
  J Appl Toxicol.
  
  Volume: 36 Pages: 35-37
- DOI
  10.1002/jat.3141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15001, KAKENHI-PROJECT-15K15098, KAKENHI-PROJECT-25293037
[Journal Article] Zomepirac acyl glucuronide is responsible for zomepirac-induced acute kidney injury in mice2016
- Author(s)
  Iwamura A, Watanabe K, Akai S, Nishinosono T, Tsuneyama K, Oda S, Kume T, Yokoi T.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 44 Pages: 888-896
- DOI
  10.1124/dmd.116.069575
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15098, KAKENHI-PROJECT-15K21057, KAKENHI-PROJECT-15K15001
[Journal Article] Toxicological evaluation of acyl glucuronides utilizing half-lives, peptide adducts, and immunostimulation assays.2015
- Author(s)
  Atsushi Iwamura, Masahito Ito, Hideaki Mitsui, Jun Hasegawa, Keigo Kosaka, Ichiro Kino, Minoru Tsuda, Miki Nakajima, Tsuyoshi Yokoi and Toshiyuki Kume.
- Journal Title
  
  Toxicol. In Vitro
  
  Volume: 30 Pages: 241-249
- DOI
  10.1016/j.tiv.2015.10.013
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293037
[Journal Article] Role of P450-mediated metabolism and identification of novel thiol-conjugated metabolites in mice with phenytoin-induced liver injury.2015
- Author(s)
  Sasaki E, Iwamura A, Tsuneyama K, Fukami T, Nakajima M, Kume T, Yokoi T.
- Journal Title
  
  Toxicol. Lett.
  
  Volume: 232 Pages: 79-88
- DOI
  10.1016/j.toxlet.2014.10.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-25293037, KAKENHI-PROJECT-25670175, KAKENHI-PROJECT-15K15001
[Journal Article] A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development2015
- Author(s)
  Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi, and Miki Nakajima
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 30 Issue: 1 Pages: 30-51
- DOI
  10.1016/j.dmpk.2014.12.001
- NAID
  50014415979
- ISSN
  1347-4367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293037
[Journal Article] Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice.2015
- Author(s)
  Takai S, Higuchi S, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T.
- Journal Title
  
  J. Appl. Toxicol.
  
  Volume: 35 Pages: 142-151
- DOI
  10.1002/jat.3002
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-25293037, KAKENHI-PROJECT-15K15001
[Journal Article] Carbamazepine-induced liver injury required CYP3A-mediated metabolism and glutathione depletion in rats.2015
- Author(s)
  Azumi Iida, Eita Sasaki, Shingo Oda, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Pages: 958-968
- DOI
  10.1124/dmd.115.063370
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15001
[Journal Article] Development of a cell-based assay system considering drug metabolism and immune- and inflammatory-related factors for the risk assessment of drug-induced liver injury2014
- Author(s)
  Azusa Yano, Shingo Oda, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Txicol. Lett.
  
  Volume: in press Pages: 13-24
- DOI
  10.1016/j.toxlet.2014.04.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24659073, KAKENHI-PROJECT-25293037
[Journal Article] An orphan esterase ABHD10 mudolates probenecid acyl glucuronidation in human liver.2014
- Author(s)
  Yusuke Ito, Tatsuki Fukami, Tsuyoshi Yokoi, and Miki Nakajima
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 12 Pages: 2109-2116
- DOI
  10.1124/dmd.114.059485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293037
[Journal Article] Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs.2014
- Author(s)
  Miyashita T, Kimura K, Fukami T, Nakajima M, Yokoi T
- Journal Title
  
  Drug Metabolism and Dispositions
  
  Volume: 42 Pages: 1-8
- DOI
  10.1124/dmd.113.054478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293037
[Journal Article] 薬物代謝と肝障害2014
- Author(s)
  横井毅
- Journal Title
  
  月刊薬事
  
  Volume: 56 (じほう出版) Pages: 21-25
- Data Source
  KAKENHI-PROJECT-24659073
[Journal Article] 薬物性肝障害における免疫・炎症因子の関与2014
- Author(s)
  織田進吾、横井毅
- Journal Title
  
  日本皮膚アレルギー・接触皮膚炎学会雑誌
  
  Volume: 8 (in press) (日本皮膚アレルギー・接触皮膚炎学会出版)
- Data Source
  KAKENHI-PROJECT-24659073
[Journal Article] Involvement of oxidative stress and immune- and inframmation-related factors in azathioprine-induced liver injury.2014
- Author(s)
  Matsuo K, Sasaki E, Higuchi S, Takai S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T.
- Journal Title
  
  Txicol. Lett
  
  Volume: 224(2) Pages: 215-224
- DOI
  10.1016/j.toxlet.2013.10.025
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-25293037
[Journal Article] 薬物代謝と免疫・炎症を考慮した薬物性肝障害の理解と展望2014
- Author(s)
  横井毅
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 143 (in press) (日本薬理学会出版)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659073
[Journal Article] 体内動態と薬物相互作用の基礎と応用-食品成分への展開-2013
- Author(s)
  横井毅
- Journal Title
  
  食品加工技術
  
  Volume: 33 (日本食品機械研究会出版) Pages: 7-13
- NAID
  40019636439
- Data Source
  KAKENHI-PROJECT-24659073
[Journal Article] A novel mouse model for phenytoin-induced liver injury : involvement of immune-related factors and P450-mediated metabolism2013
- Author(s)
  Eita Sasaki, Kentaro Matsuo, Azumi Iida, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. Sci.
  
  Volume: 136 Pages: 250-263
- DOI
  10.1093/toxsci/kft184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659073
[Journal Article] Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury.2012
- Author(s)
  Satonori Higuchi, et al
- Journal Title
  
  J. Appl. Toxicol.
  
  Volume: (in press) Pages: 815-822
- DOI
  10.1002/jat.1706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174, KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24659073
[Journal Article] Involvement of immune-related factors in diclofenac-induced acute liver in mice.2012
- Author(s)
  Yano A.
- Journal Title
  
  Toxicology
  
  Volume: 293(1-3) Pages: 107-114
- DOI
  10.1016/j.tox.2012.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590433, KAKENHI-PROJECT-24659073
[Journal Article] Th2 cytokines-mediated　methimazole-induced liver injury in mice.2012
- Author(s)
  Masanori Kobayashi, Satorori Higuchi, Mika Ide, Satomi Nishikawa, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi.
- Journal Title
  
  J. Appl. Toxicol.
  
  Volume: 32 Pages: 823-833
- DOI
  10.1002/jat.2731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659073
[Journal Article] Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries2012
- Author(s)
  Yoshikawa Y, Miyashita T, Higuchi S, Tsuneyama K, et al.
- Journal Title
  
  Toxcol. Appl. Pharmacol.
  
  Volume: 264(1) Pages: 42-50
- DOI
  10.1016/j.taap.2012.06.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24659073
[Journal Article] Hepatoprotecitve effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models.2012
- Author(s)
  Taisha Miyashita, Yasuyuki Toyoda, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi.
- Journal Title
  
  J. Toxicol. Sci
  
  Volume: 37 Pages: 931-942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659073
[Journal Article] Metabolic activation and inflammation reactions involved in carbamazepine-induced liver injury2012
- Author(s)
  Higuchi S, Yano A, Takai S, Tsuneyama K, et al.
- Journal Title
  
  Toxicol. Sci
  
  Volume: 130(1) Pages: 4-16
- DOI
  10.1093/toxsci/kfs222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24659073
[Journal Article] Mechanism of exacebrative effect of progesterone on drug-induced liver injury2012
- Author(s)
  Yasuyuki Toyoda, Shinya Endo, Koichi Tsuneyama, Taishi Miyashita, Azusa Yano, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxcol. Sci.
  
  Volume: 126 Pages: 16-27
- DOI
  10.1093/toxsci/kfr326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174, KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24659073
[Journal Article] Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.2012
- Author(s)
  Yu Yamaura, Miki Nakajima, Shingo Takagi, Tatsuki Fukami, Koichi Tsuneyama, and Tsuyoshi Yokoi
- Journal Title
  
  PLoS One
  
  Volume: 7
- DOI
  10.1371/journal.pone.0030250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174, KAKENHI-PROJECT-24390181
[Journal Article] Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury.2012
- Author(s)
  Masakazu Kakuni, Mayu Morita, Kentaro Matsuo, Yumiko Katoh, Miki Nakajima, Chise Tateno, and Tsuyoshi Yokoi.
- Journal Title
  
  Toxicol. Lett.
  
  Volume: 214 Pages: 9-18
- DOI
  10.1016/j.toxlet.2012.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659073
[Journal Article] PPARα is regulated by miR-21 and miR-27b in human liver2011
- Author(s)
  Kida K, Nakajima M, Mohri T, Oda Y, Takagi S, Fukami T, Yokoi T
- Journal Title
  
  Pharm. Res.
  
  Volume: 28 Pages: 2467-2476
- DOI
  10.1007/s11095-011-0473-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] MicroRNAs from biology to future pharmacotherapy : Regulation of cyto chrome P450s and nuclear receptors2011
- Author(s)
  Nakajima M, Yokoi T
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 131 Pages: 330-337
- DOI
  10.1016/j.pharmthera.2011.04.009
- NAID
  120003141910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Toxicological implications of modulation of gene expression by microRNAs2011
- Author(s)
  Yokoi T, Nakajima M
- Journal Title
  
  Toxicol. Sci.
  
  Volume: 123 Pages: 1-14
- DOI
  10.1093/toxsci/kfr168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Toxicological evaluation of acyl glucuronides of NSAIDs using HEK293 cells stably expressing human UGT and human hepatocytes2011
- Author(s)
  Toshihisa Koga, Ryoichi Fujiwara, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 39 Pages: 54-60
- DOI
  10.1124/dmd.110.035600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174
[Journal Article] MicroRNAs regulate human hepatocyte nuclear factor 4αmodulating the expression of metabolic enzymes and cellular cycle2010
- Author(s)
  Takagi S, Nakajima M, Kida K, Yamaura Y, Fukami T, Yokoi T
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 4415-4422
- DOI
  10.1074/jbc.m109.085431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Human CYP2E1 is regulated by miR-3782010
- Author(s)
  Mohri T, Nakajima M, Fukami T, Takamiya M, Aoki Y, Yokoi T
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 79 Pages: 1045-1052
- DOI
  10.1016/j.bcp.2009.11.015
- NAID
  120002029018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Interleukin-17 is involved inα-naphthylisothiocyanate-induced liver injury in mice2010
- Author(s)
  Masanori Kobayashi, Satonori Higuchi, Katsuhiko Mizuno, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxicology
  
  Volume: 275 Pages: 50-57
- DOI
  10.1016/j.tox.2010.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174
[Journal Article] Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b2009
- Author(s)
  Komagata S, Nakajima M, Takagi S, Mohri T, Taniya T, Yokoi T
- Journal Title
  
  Mol. Pharmacol.
  
  Volume: 76 Pages: 702-709
- DOI
  10.1124/mol.109.056986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity2009
- Author(s)
  Yukitaka Yoshikawa, Hiroko Hosomi, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. In Vitro
  
  Volume: 23 Pages: 1179-1187
- DOI
  10.1016/j.tiv.2009.05.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174
[Journal Article] Mitabolic activation of benzodiazepine by CYP3A42009
- Author(s)
  Katsuhiko Mizuno, Miki Katoh, Hirotoshi Okumura, Nao Nakagawa, Toru Negishi, Takanori Hashizume, Miki Nakajima, Tsuyoshi Yokoi
- Journal Title
  
  Drug Metab. Dispos 37
  
  Pages: 345-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] MicroRNA regulates human vitamin D receptor2009
- Author(s)
  Mohri T, Nakajima M, Takagi S, Komagata S, Yokoi T
- Journal Title
  
  Int. J. Cancer
  
  Volume: 125 Pages: 1328-1333
- DOI
  10.1002/ijc.24459
- NAID
  130005024425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Halothane-induced liver injury is mediated by interleukin-17 in mice2009
- Author(s)
  Eisuke Kobayashi, Masanori Kobayashi, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. Sci.
  
  Volume: 111 Pages: 302-310
- DOI
  10.1093/toxsci/kfp165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174
[Journal Article] Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants : naphthalene, styrene, and toluene2008
- Author(s)
  Tatsuki Fukami, Miki Katoh, Tsuyoshi Yokoi, Miki Nakajima
- Journal Title
  
  Chem.Res.Toxicol 21
  
  Pages: 720-725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Regulatiion of insulin-like growth factor binding protein-1 and lipoprotein lipase by aryl hydrocarbon receptor2008
- Author(s)
  Keiichi Minami, Miki Nakajima, Yuto Fujiki, Miki Katoh, Frank J. Gonzalez, Tsuyoshi Yokoi
- Journal Title
  
  J.Tox.Sci 33
  
  Pages: 405-413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Post-transcriptional regulation of human pregnane X receptor by microRNA affects the expression of cytochrome P450 3A42008
- Author(s)
  Shingo Takagi, Miki Nakajima, Takuya Mohri, Tsuyoshi Yokoi
- Journal Title
  
  J.Biol.Chem 283
  
  Pages: 9674-9680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Glucuronidation of thyroxine in human liver, jejunum, and kidney microsomes2007
- Author(s)
  Hiroyuki Yamanaka, Miki Nakajima, Miki Katoh, Tsuyoshi Yokoi
- Journal Title
  
  Drug Metab. Dispos 35
  
  Pages: 1642-7648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Change of drug excretory pathway by CCl4-induced liver dysfunction in rat2007
- Author(s)
  Hirotoshi Okumura, Miki Katoh, Keiichi Minami, Miki Nakajima, Tsuyoshi Yokoi
- Journal Title
  
  Biochem.Pharmacol 74
  
  Pages: 488-495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Knockdown of γ-glutamylsysteine synthetase in rat causes acetaminophen-induced hepatotoxicity2007
- Author(s)
  Sho Akai, Hiroko Hosomi, Keiichi Minami, Koichi Tsuneyama, Miki Katoh, Miki Nakajima, Tsuyoshi Yokoi
- Journal Title
  
  J.Biol.Chem 282
  
  Pages: 23996-24003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Gene expression analyses for hepatotoxicity in thioacetamide administered rat by DNA microarrays2006
- Author(s)
  Keiichi Minami, Rawiwan Maniratanachote, Miki Katoh, Miki Nakajima, Tsuyoshi Yokoi
- Journal Title
  
  Mut. Res 603
  
  Pages: 64-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Kinetic analyses for species differences in P-glycoprotein-mediated drug transport2006
- Author(s)
  Miki Katoh, Naoto Suzuyama, ToshiyukiTakeuchi, Sumie Yoshitomi, Satoru Asahi, Tsuyoshi Yokoi
- Journal Title
  
  J.Pharm.Sci 95
  
  Pages: 2673-2683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Simultaneousmeasurement of gene expression for hepatotoxicity in thioacetamide-administered rats by DNA micro arrays.2006
- Author(s)
  Minami, K., Maniratanachote, R., Katoh, M., Nakajima, M., Yokoi, T.
- Journal Title
  
  Mutat.Res. 603(1)
  
  Pages: 64-73
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] MicroRNA regulates the expression of human CYP1B12006
- Author(s)
  Yuki Tsuchiya, Miki Nakajima, Shingo Takagi, Takao Taniya, Tsuyoshi Yokoi
- Journal Title
  
  Cancer Res 66
  
  Pages: 9090-9098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Binding of steroidogenic factor-1 to the regulatory region might not be critical for transcriptional regulation of human CYP1B1 gene2006
- Author(s)
  Yuki Tsuchiya, Miki Nakajima, Shingo Takagi, Miki Katoh, Wenchao Zheng, Colin R Jefcoate, Tsuyoshi Yokoi
- Journal Title
  
  J.Biochem 139
  
  Pages: 527-534
- NAID
  10018846913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-γ coactivator 1α2006
- Author(s)
  Masahiro Ito, Miki Nakajima, Eriko Higashi, Rhoko Yoshida, Kiyoshi Nagata, Yasushi Yamazoe, Tsuyoshi Yokoi
- Journal Title
  
  J.Pharmacol.Exp.Ther 319
  
  Pages: 693-702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Dephosphorylation of ribosomal P0 protein in response to troglitazone-induced cytotoxicity2006
- Author(s)
  Rawiwan Maniratanachote, Keiichi Minami, Miki Katoh, Miki Nakajima, Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. Lett 166
  
  Pages: 189-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Journal Article] Detection of autoantibody to aldolase B in sera from patients with troglitazone-induced liver dysfunction.2005
- Author(s)
  Maniratanachote, R., Shibata, A., Kaneko, S., Yamamori, I, Wakasugi, T., Sawazaki, T., Katoh, K., Tokudome, S., Nakajima, M., Yokoi, T.
- Journal Title
  
  Toxicology 216(1)
  
  Pages: 15-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] Chaperone proteins involved in troglitazone-induced toxicity in human hepatoma cell lines.2005
- Author(s)
  Maniratanachote, R., Minami, K., Katoh, M., Nakajima, M., Yokoi, T.
- Journal Title
  
  Toxicol.Sci. 83(2)
  
  Pages: 293-302
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats.2005
- Author(s)
  Minami, K., Saito, T., Narahara, M., Tomita, H., Kato, H., Sugiyama, H., Katoh, M., Nakajima, M., Yokoi, T.
- Journal Title
  
  Toxicol.Sci. 87(1)
  
  Pages: 296-305
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies.2004
- Author(s)
  Nishimura, M., Naito, S., Yokoi, T.
- Journal Title
  
  Drag Metab.Pharmacokinet 19(2)
  
  Pages: 135-149
- NAID
  10012923634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] Role of aryl hydrocarbon receptor and Cyplbl in antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin.2004
- Author(s)
  Takemoto, K., Nakajima, M., Fujiki, Y., Katoh, M., Gonzalez, F.J., Yokoi, T.
- Journal Title
  
  Arch.Toxicol. 78(6)
  
  Pages: 309-315
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] Critical enhancer region to which AhR/ARNT and Sp1 bind in human CYP1B1 gene2003
- Author(s)
  Tsuchiya, Y., Nakajima, M., Yokoi, T.
- Journal Title
  
  J.Biochem. 133(5)
  
  Pages: 583-592
- NAID
  50000853730
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] Effects of histone deacetylation and DNA methylation on constitutive and TCDD-inducible expressions of human CYP1 family in MCF-7 and HeLa cells.2003
- Author(s)
  Nakajima, M., Iwanari M., Yokoi, T.
- Journal Title
  
  Toxicol.Lett. 144(2)
  
  Pages: 247-256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines.2003
- Author(s)
  Tsuchiya, Y., Nakajima, M., Itoh, S., Iwanari, M., Yokoi, T.
- Journal Title
  
  Toxicol.Sci. 72(2)
  
  Pages: 253-259
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390172
[Journal Article] MicroRNA regulates human vitamin D receptorr
- Author(s)
  Takuya Mohri, Miki Nakajima, Shingo Takagi, Tsuyoshi Yokoi
- Journal Title
  
  Int J Cance in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390049
[Patent] 肝保護作用を有するタンパク質、肝障害予防・保護用化合物のスクリーニング方法2010
- Inventor(s)
  横井毅、吉川幸孝
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Number
  2010-065172
- Filing Date
  2010-03-19
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Exploration of small RNA biomarkers in serum exosomes for testicular injury in rats.2021
- Author(s)
  Reo Kawata, Takumi Kagawa, Shingo Oda, Tsuyoshi Yokoi.
- Organizer
  60th Annual Meeting of Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] The involvement of ryanodine receptors in halothane-induced liver injury in mice.2021
- Author(s)
  Ru Jia, Shingo Oda, Tsuyoshi Yokoi.
- Organizer
  60th Annual Meeting of Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] ラットにおける胆汁うっ滞性肝障害のバイオマーカーとしての miR 218a 5p の有用性及びその機能解析2020
- Author(s)
  平吹有香，織田進吾，武内太輝，香川匠，横井毅
- Organizer
  第2回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-19K07099
[Presentation] ラットにおける胆汁うっ滞性肝障害のバイオマーカーとしてのmiR-2048a-5p の有用性及びその機能解析2020
- Author(s)
  平吹有香、織田進吾、武内太輝、香川匠、横井毅
- Organizer
  第2回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] Investigation of pathophysiological roles of miR-218a-5p in cholestatic liver injury in rats.2020
- Author(s)
  Yuka Hirabuki, Shingo Oda, Taiki Takeuchi, Takumi Kagawa, Tsuyoshi Yokoi.
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] ラットにおける胆汁うっ滞性肝障害のバイオマーカーとしての miR-218a-5p の有用性及びその機能解析2020
- Author(s)
  平吹有香，織田進吾，武内太輝，香川匠，横井毅
- Organizer
  第２回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-19K07099
[Presentation] An in vitro coculture system of human PBMCs with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury.2020
- Author(s)
  Shingo Oda, Yuka Uchida, Michael D. Aleo, Petra H. Koza-Taylor, Masanori Hizue, Lisa D. Marroquin, Jessica Whritenour, Eri Uchida, Tsuyoshi Yokoi.
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] Transcirptomic landscape in murine plasma of hepatocellular liver injury for biomarker discovery.2019
- Author(s)
  Shingo Oda, Ken Itoh, and Tsuyoshi Yokoi.
- Organizer
  IUTOX 15th International Congress of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] 胆汁酸塩経口負荷ラットにおける薬剤性肝障害の評価.2019
- Author(s)
  織田進吾, 楊馥華, 武内太輝, 横井毅.
- Organizer
  第26回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] Establishment of a novel mouse model of troglitazone-induced liver injury and analysis of its hepatotoxic mechanism.2019
- Author(s)
  Ru Jia, Shingo Oda, Koichi Tsuneyama, Yuya Urano, Tsuyoshi Yokoi.
- Organizer
  第1回日本毒性学会医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] Transcriptomic landscape in murine plasma of hepatocellular liver injury for biomarker discovery2019
- Author(s)
  Shingo Oda, Ken Ito, Tsuyoshi Yokoi
- Organizer
  15th IUTOX
- Data Source
  KAKENHI-PROJECT-19K07099
[Presentation] Application of microRNAs derived from liver sinusoidal endothelial cells to circulating biomarkers that discern pathogenesis of liver injuries.2019
- Author(s)
  Shingo Oda, Masaki Takeuchi, Sho Akai, Yuji Shirai, and Tsuyoshi Yokoi.
- Organizer
  58th Annual Meeting of Society of Toxicology, March 10-14, 2019, Baltimore Convention Center, Baltimore, Maryland, USA.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Gefitinib及びNaphthalene誘導性肺障害モデルマウスを用いたバイオマーカーとしての血中miRNA探索.2019
- Author(s)
  大矢寛子，織田進吾，横井毅.
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] Analysis of PlaAnalysis of plasma MicroRNAs as Biomarkers for Drug-induced Cholestatic Liver Injury in Rats.2019
- Author(s)
  平吹有香、織田進吾、武内太輝、香川匠、横井毅.
- Organizer
  第34回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-19H03388
[Presentation] 胆汁酸塩経口負荷ラットにおける薬剤性肝障害の評価2019
- Author(s)
  織田進吾, 楊馥華, 武内太輝, 横井毅
- Organizer
  第26回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-19K07099
[Presentation] 胆汁うっ滞性肝障害ラットのバイオマーカーとしてのmicroRNA探索2019
- Author(s)
  平吹有香，織田進吾，武内太輝，香川匠，横井毅
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-19K07099
[Presentation] Establishment of gefitinib-induced liver injury and its pathogenic mechanisms in mice.2018
- Author(s)
  Shingo Oda, Nanaka Miyazaki, Ru Jia, Koichi Tsuneyama, and Tsuyoshi Yokoi.
- Organizer
  The 8th International Congress of Asian Society of Toxicology, June 17-20, 2018, The Royal Cliff Grand Hotel, Pattaya, Thailand.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Systemic glutathione depletion causes acute kidney injury.2018
- Author(s)
  Akiko Matsubara, Shingo Oda, Ru Jia, and Tsuyoshi Yokoi.
- Organizer
  International Meeting of 22nd Microsomes and Drug Oxidations and 33rd Japanese Society of the Study of Xenobiotics, October 1-5, 2018, Ishikawa Ongakudo Hall, Kanazawa, Ishikawa, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] 胆汁うっ滞および脂肪肝を病型別に早期予測が可能な血漿miRNAバイオマーカー探索研究．2018
- Author(s)
  香川　匠、白井勇司、Tomas ZARYBNICKY、織田進吾、横井　毅
- Organizer
  2018年7月18日-７月20日、第45回日本毒性学会学術年会、大阪国際会議場グランキューブ大阪、大阪府大阪市
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] 病型および臓器特異的な毒性予測バイオマーカーとしてのmiRNA2018
- Author(s)
  横井　毅、香川　匠、　織田進吾
- Organizer
  2018年7月18日-７月20日、第45回日本毒性学会学術年会、大阪国際会議場グランキューブ大阪、大阪府大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Cellular and animal models for human drug-induced liver injury.2018
- Author(s)
  Tsuyoshi Yokoi.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology, July 1-6, 2018, Kyoto International Conference Center, Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] ゲフィチニブ誘導性肝障害マウスモデルの作成及びグルタチオン枯渇の影響．2018
- Author(s)
  織田進吾、宮崎菜々華、賈茹、常山幸一、横井　毅
- Organizer
  2018年7月18日-７月20日、第45回日本毒性学会学術年会、大阪国際会議場グランキューブ大阪、大阪府大阪市
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Involvement of microRNAs and immune- and inflammation-related factors in drug-induced liver injury.2017
- Author(s)
  Tsuyoshi Yokoi
- Organizer
  2017年7月10日～７月12日、第44回日本毒性学会学術年会、パシフィコ横浜、横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Individual variability of carbamazepine-induced liver injury in mice2017
- Author(s)
  Yasuaki Uematsu, Sho Akai, Shingo Oda, Toru Yamada, Tsuyoshi Yokoi.
- Organizer
  56th Annual Meeting of Society of Toxicology,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] 毒性理解のための薬物動態的アプローチ2017
- Author(s)
  横井　毅
- Organizer
  シンポジウム、2017年7月10日～７月12日、第44回日本毒性学会学術年会、パシフィコ横浜、神奈川県横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Establishment of a novel cell-based assay for drug-induced liver injury (DILI) potential considering immune- and inflammation-related factors.2017
- Author(s)
  Tsuyoshi Yokoi and Shingo Oda.
- Organizer
  56th Annual Meeting of Society of Toxicology, March 12-16, 2017, Baltimore Convention Center, Baltimore, Maryland, USA.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Establishment and characterization of a mouse model of rhabdomyolysis by administration of statin and fibrate.2017
- Author(s)
  Katsuhiro Watanabe, Shingo Oda, Sho Akai, Akiko Matsubara, and Tsuyoshi Yokoi.
- Organizer
  21th North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Characterization of microRNAome in rat liver sinusoidal endothelial cells and hepatocytes and their potential application to plasma biomarkers that discern pathogenesis of liver injuries2017
- Author(s)
  Shingo Oda, Masataka Takeuchi, Yuji Shirai, Sho Akai, Koichi Tsuneyama, Tsuyoshi Yokoi.
- Organizer
  56th Annual Meeting of Society of Toxicology, March 12-16, 2017, Baltimore Convention Center, Baltimore, Maryland, USA.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Characterization of microRNAome in rat liver sinusoidal endothelial cells and hepatocytes and their potential application to plasma biomarkers that discern pathogenesis of liver injuries2017
- Author(s)
  Shingo Oda, Masataka Takeuchi, Yuji Shirai, Sho Akai, Koichi Tsuneyama, Tsuyoshi Yokoi.
- Organizer
  56th Annual Meeting of Society of Toxicology,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Comparison of in vitro cytotoxicity assays using glutathione-depleted HepaRG and HepG2 cells for predicting drug-induced liver injury.2017
- Author(s)
  Jieyu Xu, Shingo Oda, Tsuyoshi Yokoi.
- Organizer
  56th Annual Meeting of Society of Toxicology,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] 特異体質性薬物性肝障害の免疫学的機序2017
- Author(s)
  横井　毅
- Organizer
  特別講演、2017年9月4日～5日、第24回日本免疫毒性学会学術年会、北里大学獣医学部講堂、青森県十和田市
- Invited
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Individual variability of carbamazepine-induced liver injury in mice.2017
- Author(s)
  Yasuaki Uematsu, Sho Akai, Shingo Oda, Toru Yamada, Tsuyoshi Yokoi.
- Organizer
  56th Annual Meeting of Society of Toxicology, March 12-16, 2017, Baltimore Convention Center, Baltimore, Maryland, USA.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Comparison of in vitro cytotoxicity assays using glutathione-depleted HepaRG and HepG2 cells for predicting drug-induced liver injury.2017
- Author(s)
  Jieyu Xu, Shingo Oda, Tsuyoshi Yokoi.
- Organizer
  56th Annual Meeting of Society of Toxicology, March 12-16, 2017, Baltimore Convention Center, Baltimore, Maryland, USA.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02616
[Presentation] Individual variability of carbamazepine-induced liver injury in mice.2017
- Author(s)
  Yasuaki Uematsu, Sho Akai, Shingo Oda, Toru Yamada, Tsuyoshi Yokoi.
- Organizer
  56th Annual Meeting of Society of Toxicology
- Place of Presentation
  Baltimore Convention Center, Baltimore, Maryland, USA.
- Year and Date
  2017-03-12
- Data Source
  KAKENHI-PROJECT-15K15001
[Presentation] ラモトリギン誘導性肝障害発症メカニズムのC57BL/6J マウスを用いた解析.2016
- Author(s)
  赤井翔、織田進吾、横井毅.
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  愛知県産業労働センターウインクあいち、愛知県名古屋市
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-15K15001
[Presentation] メチマゾール誘導性肝障害ラットモデルの作成及び肝障害発症メカニズムの解析2015
- Author(s)
  赤井　翔、上松泰明、常山幸一、織田進吾、横井毅．
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂、石川県金沢市
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-15K15001
[Presentation] ジクロフェナク誘導性肝障害におけるアシルグルクロナイドの関与2015
- Author(s)
  清木俊雄、織田進吾、横井毅
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂、石川県金沢市
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] Toxicological evaluation of acyl glucuronides utilizing half-lives, peptide adducts, and immunostimulation assays.2015
- Author(s)
  岩村　篤、伊藤雅仁、三井英晃、長谷川洵、小坂圭吾、木野一郎、津田実、中島美紀、横井毅、久米利行
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  タワーホール船堀、東京都江戸川区
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] Toxicological evaluation of acyl glucuronides utilizing half-lives, peptide adducts, and immunostimulation assays.2015
- Author(s)
  岩村　篤、伊藤雅仁、三井英晃、長谷川洵、小坂圭吾、木野一郎、津田実、中島美紀、横井毅、久米利行．
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  タワーホール船堀、東京都江戸川区
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K15001
[Presentation] メチマゾール誘導性肝障害ラットモデルの作成及び肝障害発症メカニズムの解析．2015
- Author(s)
  赤井　翔、上松泰明、常山幸一、織田進吾、横井毅
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂、石川県金沢市
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] HepaRG細胞および免疫・炎症関連遺伝子マーカーを用いた薬剤性肝障害リスク評価系の構築2015
- Author(s)
  織田進吾、松尾研太郎、横井毅
- Organizer
  第5回名古屋大学医学系研究科・生理学研究所合同シンポジウム
- Place of Presentation
  生理学研究所大会議室、愛知県岡崎市
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] Acyl glucuronide involved in zomepirac-induced nephrotoxicity.2015
- Author(s)
  渡辺克仁、岩村　篤、赤井　翔、西之園　翼、常山幸一、織田進吾、横井毅．
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  タワーホール船堀、東京都江戸川区
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K15001
[Presentation] Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis.2015
- Author(s)
  白井勇司、織田進吾、牧野早也香、常山幸一、横井毅
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  タワーホール船堀、東京都江戸川区
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K15001
[Presentation] Investigation of the role of acyl glucuronide in diclofenac-induced liver injury in mice.2015
- Author(s)
  織田進吾、清木俊雄、横井毅
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  タワーホール船堀、東京都江戸川区
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] 薬物性肝障害の動物モデルの作出と発症メカニズムの解析2014
- Author(s)
  横井　毅
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市青年会館ホール、熊本市
- Invited
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] Identification of a P450-mediated hepatotoxicity-associated glutathione-conjugate of phenytoin in phenytoin-induced liver injury in mice2014
- Author(s)
  Tsuyoshi Yokoi, Eita Sasaki, Atsushi Iwamura, Tatsuki Fukami, Miki Nakajima, Toshiyuki Kume
- Organizer
  53rd Annual Meeting and ToxExpo
- Place of Presentation
  Phenixコンベンションセンター, Phoenix, USA
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] A novel mouse model for phenytoin-induced liver injury : involvement of immune-related factors and P450-mediated metabolism2014
- Author(s)
  Eita Sasaki, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  53rd Annual Meeting and ToxExpo
- Place of Presentation
  Phenixコンベンションセンターー, Phoenix, USA
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 薬物性肝障害の多様性への対応と予測2014
- Author(s)
  横井毅
- Organizer
  第42回構造活性相関シンポジウム
- Place of Presentation
  くまもと森都心プラザプラザホール（熊本県熊本市）
- Year and Date
  2014-11-13
- Invited
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] 薬物性肝障害の動物モデルの作出と発症メカニズムの解析2014
- Author(s)
  横井毅
- Organizer
  シンポジウム「特異体質性薬物毒性の研究最前線」日本薬学会第134年会
- Place of Presentation
  熊本市青年会館ホール、熊本
- Year and Date
  2014-03-30
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 薬物性肝障害の予測試験系の開発とバイオマーカー2014
- Author(s)
  横井毅
- Organizer
  薬物動態談話会4月例会
- Place of Presentation
  千里ライフサエンスセンター（大阪府豊中市）
- Year and Date
  2014-04-15
- Invited
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] 特異体質性薬物毒性の研究最前線：薬物性肝障害の動物モデルの作出と発症メカニズムの解析2014
- Author(s)
  横井　毅
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市青年会館ホール、熊本市
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 特異体質性肝障害のバイマーカーの探索と応用2014
- Author(s)
  横井毅
- Organizer
  日本代替法学会第27回年会シンポジウム
- Place of Presentation
  横浜国立大学教育人間学部講義棟８号館103教室（神奈川県横浜市）
- Year and Date
  2014-12-06
- Invited
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] 薬の副作用発現の個人差と創薬2014
- Author(s)
  横井毅
- Organizer
  名古屋大学予防早期医療創成センター第4回ワークショップ
- Place of Presentation
  名古屋大学野依記念学術交流館、名古屋
- Year and Date
  2014-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] フェニトイン誘導性肝障害マウスの作出と発症メカニズムの解明2013
- Author(s)
  佐々木永太、常山幸一、深見達基、中島美紀、横井毅
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  幕張メッセ、千葉 (ポスター)
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 薬物性肝障害における免疫学的因子の関与2013
- Author(s)
  横井　毅
- Organizer
  第43回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
- Place of Presentation
  ホテル日航金沢、金沢市
- Invited
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] 薬物誘導性肝障害に免疫学的機序が果たす役割2013
- Author(s)
  横井毅
- Organizer
  第155回日本獣医学会学術集会
- Place of Presentation
  東京大学農学部講堂、文京区、東京
- Year and Date
  2013-03-30
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] Biomarkers for Drug-induced Liver Injury.2013
- Author(s)
  横井　毅
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  江戸川区船堀タワーホール、東京都江戸川区
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] A reactive metabolite formed by P450, which is readily subjected to glutathione conjugation, would be causal for phenytoin-induced liver injury2013
- Author(s)
  Eita Sasaki, Atsushi Iwamura, Toshiyuki Kume, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  船堀タワーホール、江戸川区、東京都 (ポスター)
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] アシルグルクロニドによる細胞毒性のメカニズム解析2013
- Author(s)
  宮下泰志、深見達基、中島美紀、横井　毅
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  幕張メッセ、千葉市
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] 薬物性肝障害における免疫学的因子の関与2013
- Author(s)
  横井毅
- Organizer
  シンポジウム「薬疹の理解に必要な免疫学」第43回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
- Place of Presentation
  ホテル日航金沢、金沢市
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 薬疹の理解に必要な免疫学：薬物性肝障害における免疫学的因子の関与2013
- Author(s)
  横井毅
- Organizer
  第43回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
- Place of Presentation
  ホテル日航金沢、金沢市
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] A reactive metabolite formed by P450, which is readily subjected to glutathione conjugation, would be causal for phenytoin-induced liver injury2013
- Author(s)
  9. Eita Sasaki, Atsushi Iwamura, Toshiyuki Kume, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  江戸川区船堀タワーホール、東京都江戸川区
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] アザチオプリン誘導性肝障害マウスにおける発症メカニズムの解析2013
- Author(s)
  松尾研太朗、樋口悟法、常山幸一、深見達基、中島美紀、横井毅
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  幕張メッセ、千葉 (ポスター)
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] Biomarkers for Drug-induced Liver Injury2013
- Author(s)
  横井　毅
- Organizer
  Symposium at 28th Japanese Society for the study of Xenobyobics (JSSX)
- Place of Presentation
  江戸川区船堀タワーホール、東京都江戸川区
- Invited
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] Biomarkers for Drug-induced Liver Injury2013
- Author(s)
  横井毅
- Organizer
  Symposium at 28^<th> Japanese Society for the study of Xenobyobics (JSSX)
- Place of Presentation
  船堀タワーホール、江戸川区、東京都
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] Regulation of cytochrome P450s and nuclear receptors by microRNAs and its toxicological implications2012
- Author(s)
  横井毅
- Organizer
  2012 ADME & Predictive Toxicology Meeting
- Place of Presentation
  Holiday Inn Munich City Centre (Germany)(招待講演)
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] カルバマゼピン誘導性肝障害における代謝的活性化と炎症の関与2012
- Author(s)
  樋口悟法、常山幸一、深見達基、中島美紀、横井毅
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台国際センター、仙台 (ポスター)
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 薬物誘発性肝障害における代謝と免疫の役割2012
- Author(s)
  横井　毅
- Organizer
  第26回日本薬物動態学会ワークショップ
- Place of Presentation
  慶応義塾大学薬学部（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 体内動態と薬物相互作用の基礎と応用～食品成分への展開～2012
- Author(s)
  横井　毅
- Organizer
  第10回日本食品・機械研究会フォーラム
- Place of Presentation
  富士教育研修所（静岡県）
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 薬物性肝障害の予測試験系とバイオマーカー2012
- Author(s)
  横井　毅
- Organizer
  第16回薬物動態談話会セミナー
- Place of Presentation
  東レ総合研修センター（静岡県）
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] Metabolic activation and inflammation reactions involved in carbamazepine-induced liver injury2012
- Author(s)
  Tsuyoshi Yokoi, Satonori Higuchi, Azusa Yano, Shohei Takai, Koichi Tsuneyama, Tatsuki Fukami, and Miki Nakajima
- Organizer
  18th North American Regional Meeting
- Place of Presentation
  Dallas, USA (Poster)
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 特異体質性薬物性肝障害モデル2012
- Author(s)
  横井　毅
- Organizer
  第59回日本実験動物学会総会
- Place of Presentation
  ビーコンプラザ別府市（大分県）
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 特異体質性薬物性肝障害の前臨床基礎研究2012
- Author(s)
  横井　毅
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台国際センター（宮城県）
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 毒作用発現バイオマーカーとしてのマイクロRNA2012
- Author(s)
  横井　毅
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台国際センター（宮城県）
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] Prediction of immune-mediated drug-induced liver injury in preclinical Drug development2011
- Author(s)
  横井毅
- Organizer
  World Pharma Congress 2011, Symposium
- Place of Presentation
  Loews Philadelphia Hotel (USA)(招待講演)
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Approaches to predict drug-induced liver injur2011
- Author(s)
  横井毅
- Organizer
  4^<th> Asia-Pacific ISSX Meeting, Symposium
- Place of Presentation
  National Cheng Kung University, Tainan (Taiwan)(招待講演)
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Prediction of immune-mediated drug-induced liver injury in preclinical Drug development2011
- Author(s)
  横井毅, 中島美紀
- Organizer
  4^<th> Asia-Pacific ISSX Meeting, Symposium
- Place of Presentation
  National Cheng Kung University, Tainan (Taiwan)(招待講演)
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] MicroRNA regulation of cytochrome P450 drug-metabolizing enzymes2011
- Author(s)
  横井毅
- Organizer
  Experimental Biology 2011, Symposium
- Place of Presentation
  Washington DC Convention Center (USA)(招待講演)
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Involvement of interleukin-17 in drug-induced liver injury in mice2010
- Author(s)
  Eisuke Kobayashi, Masanori Kobayashi, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  SOT 49th Annual Meeting
- Place of Presentation
  Hilton Salt Lake City Center Hotel, Salt Lake City-USA
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Rogulation of human cytochrome P450s and nuclear receptors by micro RNAs.2010
- Author(s)
  横井毅
- Organizer
  18^<th> International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Beijing International Conference Censer(China)(招待講演)
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PROJECT-22659031
[Presentation] 代謝物を考慮した薬物誘導性肝障害の予測試験系の検討2010
- Author(s)
  横井毅
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖繩コンベンションセンター(沖繩県)(招待講演)
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-22659031
[Presentation] Approaches to predict idiysyncratic and immune-mediated drug-induced liver injury.2010
- Author(s)
  横井毅
- Organizer
  25^<th> JSSX Annual Meeting
- Place of Presentation
  大宮ソニックシティ(埼玉県)(招待講演)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-22659031
[Presentation] Approaches to predict idiysyncratic and immune-mediated drug-induced liver injury.2010
- Author(s)
  横井毅
- Organizer
  25^<th>JSSX Annual Meeting(招待講演)
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] 代謝物を考慮した薬物誘導性肝障害の予測試験系の検討2010
- Author(s)
  横井毅
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄コンベンションセンター(沖縄県) 招待講演
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Human PPARa is regulated by miR-212010
- Author(s)
  Katsuhiko Kida, Miki Nakajima, Takuya Mohri, Yuki Oda, Shingo Tagagi, Tatsuki Fukami, and Tsuyoshi Yokoi
- Organizer
  9th International ISSX Meeting
- Place of Presentation
  Istanbul Conventin & Exihition Center, Istanbul-Tukey
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Mechanism of hepatoprotective effect of tamoxifen against drug-induced liver injury2010
- Author(s)
  Yukitaka Yoshikawa, Yasuyuki Toyoda, Satonori Higuchi, Tohru Tsuku, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  9th International ISSX Meeting
- Place of Presentation
  Istanbul Conventin & Exihition Center, Istanbul-Tukey
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] 薬物代謝酵素の発現調節と薬物性肝障害2010
- Author(s)
  横井毅
- Organizer
  第26回日本薬学会創薬セミナー
- Place of Presentation
  八ヶ岳ロイヤルホテル(山梨県)(招待講演)
- Year and Date
  2010-07-29
- Data Source
  KAKENHI-PROJECT-22659031
[Presentation] Regulation of human cytochrome P3450s and nuclear receptors by micro RNAs.2010
- Author(s)
  横井毅
- Organizer
  18^<th> International Symposium on Microsomes and Drug Oxidations(招待溝演)
- Place of Presentation
  Beijing International Conference Center(China)
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] 肝毒性評価:発現メカニズム解明へのアプローチ2010
- Author(s)
  横井毅
- Organizer
  HAB学術年会(招待溝演)
- Place of Presentation
  昭和大学上条講堂(東京都)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] 肝毒性評価発現メカニズム解明へのアプローチ2010
- Author(s)
  横井毅
- Organizer
  HAB学術年会
- Place of Presentation
  昭和大学上条講堂(東京都)(招待講演)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22659031
[Presentation] 薬物代謝酵素の発現調節と薬物性肝障害2010
- Author(s)
  横井毅
- Organizer
  第26回日本薬学会創薬セミナー
- Place of Presentation
  八ヶ岳ロイヤルホテル(山梨県) 招待講演
- Year and Date
  2010-07-29
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] 薬物性肝障害の予測試験系とバイオマーカー2010
- Author(s)
  横井毅
- Organizer
  第14回薬物動態談話会セミナー
- Place of Presentation
  東レ(株)研修センケー(静岡県) 招待講演
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] 薬物性肝障害の予測試験系とバイオマーカー2010
- Author(s)
  横井毅
- Organizer
  第14回薬物動態談話会セミナー
- Place of Presentation
  東レ(株)研修センター(静岡県)(招待講演)
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-22659031
[Presentation] 薬物代謝酵素とmicroRNA制御2009
- Author(s)
  横井毅
- Organizer
  CBI学会
- Place of Presentation
  日本化学会化学会館 (東京)
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Human hepatocyte nuclear factor 4a is regulated bymiR-242009
- Author(s)
  Shingo Takagi, Miki Nakajima, Katsuhiko Kida, Tatsuki Fukami, and Tsuyoshi Yokoi
- Organizer
  3rd Asia Pacific ISSX Meeting
- Place of Presentation
  The Imperial Queen's Park Hotel, Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Halothane-induced liver injury is mediated by interleukin-17 in mice2009
- Author(s)
  Tsuyoshi Yokoi, Eisuke Kobayashi, Tatsuki Fukami, and Miki Nakajima
- Organizer
  16^<th> North American Regional ISSX Meeting
- Place of Presentation
  Baltimore Marriott Waterfront, Baltimore, USA
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Metabolic activation of benzodiazepines by CYP3A42009
- Author(s)
  Katsuhiko Mizuno, Miki Katoh, HirotoshiOkumura, Nao Nakagawa, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  3rd Asia Pacific ISSX Meeting
- Place of Presentation
  The Imperial Queen's Park Hotel, Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] MiR-24 regulates human HNF4a expression2009
- Author(s)
  Shingo Takagi, Miki Nakajima, Katsuhiko Kida, Tatsuki Fukami, and Tsuyoshi Yokoi
- Organizer
  16th International Conference on Cytochrome P450
- Place of Presentation
  Bankoku Shinryokan, Nago, Japan
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Knockdown of superoxide dismutase 2 in BRL3 cell and rat to evaluate the drug-induced hepatotoxicity2009
- Author(s)
  Yukitaka Yoshikawa, Hiroko Hosomi, Mayu Morita, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  SOT 48th Annual Meeting
- Place of Presentation
  Baltimore Convention Center, Baltimore, USA
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] MicroRNA regulates the expression of human CYP2E12009
- Author(s)
  Takuya Mohri, Miki Nakajima, Tatsuki Fukami, and Tsuyoshi Yokoi
- Organizer
  16th International Conference on Cytochrome P450
- Place of Presentation
  Bankoku Shinryokan, Nago, Japan
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] microRNAによるヒトVDRの発現制御2008
- Author(s)
  茂利拓也、中島美紀、高木信伍、横井毅
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] 反応性代謝物を考慮した肝障害性予測試験系2008
- Author(s)
  横井毅
- Organizer
  日本薬物動態学会第22回ワークショップ招待講演
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] Micro RNAs regulate the expression of human cytochrome P450 1B1 and P450 3A42008
- Author(s)
  T. Yokoi, et al.
- Organizer
  Plenary Session on 17^<th> International Symposioum on Microsomes and Drug Oxidations
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] CYP enzymes and cancer : regulation by steroids and miRNA.2008
- Author(s)
  T. Yokoi, et al.
- Organizer
  9th Advanced Course on "Steroid Enzymesand Cancer"
- Place of Presentation
  Erice, Italy
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] CYP enzymes and cancer : regulation by steroids and miRNA2008
- Author(s)
  Tsuyoshi Yokoi, Miki Nakajima
- Organizer
  9th Advanced Course on "Steroid Enzymes and Cancer"
- Place of Presentation
  Erice, Italy.
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] 薬物代謝酵素と核内レセプターのmicroRNAによる発現調節2008
- Author(s)
  中島美紀、高木信伍、駒形小夜香、茂利拓也、土屋祐樹、横井毅
- Organizer
  第23回日本薬物動態学会年会, シンポジウム
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] Human CYP1B1 is regulated by microRNA, miR-27b2007
- Author(s)
  Tsuyoshi Yokoi, Shingo Takagi, Yuki Tsuchiya, Miki Katoh, Takao Taniya, Miki Nakajima
- Organizer
  15th International Conference on cytochrome P450
- Place of Presentation
  Bled, Slovenia
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] MicroRNA regulates CYP enzymes.2007
- Author(s)
  T. Yokoi
- Organizer
  Special Seminar for Biomedical Research Centre
- Place of Presentation
  Dundee-UK
- Year and Date
  2007-09-12
- Data Source
  KAKENHI-PROJECT-19659036
[Presentation] Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase via aryl hydrocarbon receptor2006
- Author(s)
  Keiichi Minami, Miki Nakajima, Yuto Fujiki, Miki Katoh, Frank J. Gonzalez, Tsuyoshi Yokoi
- Organizer
  20^<th> IUBMB International Congress of Biochemistry and Molecular Biology and 11^<th> FAOBMB Congress
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] 薬物排泄に及ぼす肝障害の影響2006
- Author(s)
  奥村浩敏、加藤美紀、南圭一、中島美紀、横井毅
- Organizer
  日本薬学会北陸支部会
- Place of Presentation
  金沢
- Year and Date
  2006-07-08
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] Human cytochrome P450 CYP1B1 is a target of microRNA, miR-27b2006
- Author(s)
  Yuki Tsuchiya, Shingo Takagi, Miki Nakajima, Miki Katoh, Takao Taniya, Tsuyoshi Yokoi
- Organizer
  20^<th> IUBMB International Congress of Biochemistry and Molecular Biology and 11^<th> FAOBMB Congress
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] Human CYP1B1 is regulated by microRNA, miR-27b2006
- Author(s)
  Shingo Takagi, Yuki Tsuchiya, Miki Nakajima, Miki Katoh, Takao Taniya, Tsuyoshi Yokoi
- Organizer
  第21回日本薬物動態学会年会
- Place of Presentation
  シンポジウム, 東京
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] Metabolic activation and drug induced hepatotoxicity-the troglitazone case-2006
- Author(s)
  Tsuyoshi Yokoi
- Organizer
  第21回日本薬物動態学会年会
- Place of Presentation
  シンポジウム, 東京
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] Ribosomal protein P0 dephosphorylation associated with troglitazone-induced cytotoxicity2006
- Author(s)
  Rawiwan Maniratanachote, Miki Katoh, Mik Nakajima, Tsuyoshi Yokoi
- Organizer
  The 1^<st> Asia Pacific ISSX Meeting
- Place of Presentation
  Jeju, Korea
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] ヒトCYP1B1遺伝子の発現はmicroRNAにより制御される2006
- Author(s)
  高木信吾、土屋佑樹、中島美紀、加藤美紀、谷屋隆雄、横井毅
- Organizer
  日本薬学会北陸支部会
- Place of Presentation
  金沢
- Year and Date
  2006-07-08
- Data Source
  KAKENHI-PROJECT-18390049
[Presentation] 薬物性肝障害とバイオマーカーとしてのマイクロRNA
- Author(s)
  横井　毅
- Organizer
  安全性評価研究会セミナー
- Place of Presentation
  武田バイオ開発センター講堂（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] 薬の副作用発現の個人差と創薬
- Author(s)
  横井　毅
- Organizer
  名古屋大学予防早期医療創成センター第４回ワークショップ
- Place of Presentation
  名古屋大学野依記念学術交流館、名古屋市
- Invited
- Data Source
  KAKENHI-PROJECT-24659073
[Presentation] ヒトにおけるプロベネシドアシルグルクロニド生成と分解を担う酵素の同定
- Author(s)
  伊藤祐介、深見達基、中島美紀、横井　毅
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢大学自然研研究科棟、金沢市
- Data Source
  KAKENHI-PROJECT-25293037
[Presentation] 薬物動態・安全性とmicroRNA
- Author(s)
  横井　毅
- Organizer
  第４回新たな創薬パラダイムの創出、システム薬学研究機構シンポジウム
- Place of Presentation
  東京大学医科学研究所（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-24659073

1. KAMATAKI Tetsuya (00009177)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. ITOH Susumu (70223154)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. NAKAJIMA Miki (70266162)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
4. SAKUMA Tsutomu (30250468)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 澤田稔 (30215917)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. NAKAYAMA Kazuo (20261323)

# of Collaborated Projects: 3 results

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7. KITAMURA Ryuji (40221212)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 織田進吾 (10725534)

# of Collaborated Projects: 3 results

# of Collaborated Products: 48 results
9. TABATA Yashuiko (50211371)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KATOH Miki (70345594)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
11. TANAKA Noriaki (10127566)

# of Collaborated Projects: 2 results

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12. MOCHITATE Katsumi (20132863)

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13. KONDO Eisaku (30252951)

# of Collaborated Projects: 2 results

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14. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 2 results

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15. KOBAYASHI Naoya (10325102)

# of Collaborated Projects: 1 results

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16. YAMATSUJI Tomoki (40379730)

# of Collaborated Projects: 1 results

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17. KATO Jun (90379743)

# of Collaborated Projects: 1 results

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18. NAKANISHI Toru (30243463)

# of Collaborated Projects: 1 results

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19. KATAYAMA Hiroshi (90161067)

# of Collaborated Projects: 1 results

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20. FUKAMI Tatsuki (00532300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
21. HARADA Shoji (60086618)

# of Collaborated Projects: 1 results

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22. YOSHIOKA Hisabumi (80108935)

# of Collaborated Projects: 1 results

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23. UMEZU Kazuo (10091828)

# of Collaborated Projects: 1 results

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24. SUZUKI Koichi (60171211)

# of Collaborated Projects: 1 results

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25. HUKUSHIMA Hirobumi (70135218)

# of Collaborated Projects: 1 results

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26. MIYAZAKI Masahiro (90116509)

# of Collaborated Projects: 1 results

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27. KOIDE Norio (20142333)

# of Collaborated Projects: 1 results

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28. HAYAKAWA Kazuichi (40115267)

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29. TORIBA Akira (50313680)

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30. KIZU Ryoichi (80143915)

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31. 勾坂薫 (70006740)

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32. 岩佐峰雄 (00021452)

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33. 寺沢浩一 (40142715)

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34. 石本剛一 (30024673)

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35. 藤田健一 (60281820)

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36. AKASU Hiroyuki

# of Collaborated Projects: 1 results

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37. EJIRI Yoko

# of Collaborated Projects: 1 results

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38. SHIMADA Noriaki

# of Collaborated Projects: 1 results

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39. NAKAJI Syuhei

# of Collaborated Projects: 1 results

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40. SADAMORI Hiroshi

# of Collaborated Projects: 1 results

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41. JANE Lebkowsky

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42. IRA J. Fox

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45. 常山幸一

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46. 松井佑介

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YOKOI Tsuyoshi 横井 毅

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特異体質性薬物性肝障害発症の個体差の決定因子の解明と予測試験系の開発Principal Investigator

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Establishment of a predictive test system for idiosyncratic drug-induced liver injury and study for evaluation of onset biomarkersPrincipal Investigator

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Factors of individual variability in onset of drug-induced liver injuryPrincipal Investigator

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Risk assessment and mechanistic analysis of adverse reactions of the acyl glucuronides.Principal Investigator

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Establishment of drug hypersensitivity animal model and investigation of the mechanism.Principal Investigator

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ヒト組織適合性抗原遺伝多型に相関して発症する特異体質性薬物性肝障害の予測系の構築Principal Investigator

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ヒト間葉系幹細胞からの肝細胞様細胞の作成と薬物動態毒性学的評価研究Principal Investigator

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MicroRNAs as biomarkers for drug-induced liver injuryPrincipal Investigator

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ヒト初代培養肝細胞におけるマイクロRNAの役割Principal Investigator

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Role of microRNA on drug-induced hepatotoxocityPrincipal Investigator

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Studies to develop the prediction system for drug metabolism, pharmacokineties and toxicity.Principal Investigator

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YOKOI Tsuyoshi 横井毅