SHIMIZU Takeshi 清水猛史

Researcher Number	00206202
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2024: 滋賀医科大学, 医学部, 非常勤講師 2008 – 2023: Shiga University of Medical Science, 医学部, 教授 2004: Shiga University of Medical Science, Department of Otorhinolaryngology, Professor, 医学部, 教授 2003: 三重大学, 医学部附属病院, 助教授 2001: Mie Univ. Faculty of Medicine associate Prof., 医学部・附属病院, 助教授 1996 – 2000: 三重大学, 医学部・附属病院, 講師 1993 – 1995: 三重大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology / Otorhinolaryngology
Keywords	Principal Investigator 鼻粘膜 / IL-8 / 粘液 / サイトカイン / 好酸球 / 慢性副鼻腔炎 / 抗原特異的免疫グロブリン / IL-10 / アポトーシス / スギ花粉症 … More / 抗原特異的IgE抗体 / メモリーT細胞 / IL-35 / 制御性T細胞 / 舌下免疫療法 / スギ・ヒノキ花粉症 / LPS / mucus / Nasal epithelium / 分泌 / 杯細胞 / モノクローナル抗体 / amphiregulin / TGF-alpha / ムチン / ＭＵＣ５ＡＣ / 鼻茸形成 / ＥＧＦ受容体 / 組織リモデリング / 上皮細胞 / アレルギー性鼻炎 / 鼻茸 / 好酸球性副鼻腔炎 / 杯細胞化生 / 末梢血単核球サブセット / ダニアレルギー性鼻炎 / 抗原親和性 / 特異的免疫グロブリン / 制御性Ｔ細胞 / スギ花粉舌下免疫療法 / 網羅的RNA解析 / 特異的IgG4 / 抗原特異的IgG4抗体 / 制御性濾胞性T細胞 / ヒノキ花粉症 / 制御性B細胞 / Eosinophil / Neutrophil / Allergy / Prostaplandin E_2 / 好中球 / アレルギー / プロスタグランディンE_2 / MUC gene / monoclonal antibody / nasal epithelium / cell culture / secretory cell / goblet cell / secretion / 線毛細胞 / 細胞分化 / マクロライド / マクロライド剤 / 細胞培養 / 分泌細胞 / Mucus secretion / Nasal gland / Mucus / Goblet cell / Nasal allergy / Chronic sinusitis / Monoclonal antibody / ELISA / 腺細胞 / 鼻汁 / ＴＮＦ－alpha / ＬＰＳ / ＩＬ－８ / ＥＧF受容体阻害薬 / 線維芽細胞 / 鼻粘膜上皮細胞 / ラット鼻粘膜 / ＥＧＦ受容体阻害薬 / ADAM / EGFR / 気道上皮細胞 / MUC5AC / 粘液産生 / 鼻副鼻腔炎 / TNFα / プロスタグランディンE2 / VEGF / リポキシン受容体 / リポキシン / 鼻科学 / エンドトキシン / 粘液糖蛋白 / 細胞増殖 … More Except Principal Investigator mucus / animal model / chronic sinusitis / 動物モデル / 慢性副鼻腔炎 / 気道液 / 好酸球性副鼻腔炎 / 凝固系因子 / 好酸球性鼻副鼻腔炎 / 耳鼻咽喉科学 / PARs / fibronectin / GM-CSF / 活性化第１０因子 / トロンビン / 線維芽細胞 / EGF受容体インヒビター / RANTES / eotaxin / TGF-beta / フィブロネクチン / 鼻茸線維芽細胞 / 血液凝固因子 / extracellular matrix / submucosal gland / remodeling / nasal polyposis / allergic rhinitis / 気道分泌 / ムチン遺伝子 / 副鼻腔 / 鼻 / 細胞外マトリックス / 粘液 / 粘膜下腺 / リモデリング / 鼻茸 / アレルギー性鼻炎 / growth factor / hyperplasia / differentiation / proliferation / gland / 粘性・弾性 / 粘性,弾性 / 粘性、弾性 / 粘液産生モデル / 腺の増殖 / 腺の分化 / 増殖因子 / 過形成 / 分化 / 増殖 / 腺細胞 / neutrophil / 3-D culture / goblet cell / mucous cell / serous cell / mucus production / airway / 粘液腔 / 気通液 / レオロジー / 奬液腺 / 奨液腺 / 粘膜産生 / 好中球 / 3D培養 / 杯細胞 / 漿液腺 / 粘液腺 / 粘液産生 / 気道 / カニクイザル / クラリスロマイシン / マクロライド / インフルエンザウイルス / 嗅粘膜 / タウ蛋白 / アミロイドβ / ヒト鼻腔 / 早期診断 / アルツハイマー病 / TSLP / IL-25 / IL-33 / プロテアーゼ / アレルゲン / 気道上皮細胞 / 抗原 / アレルギー / 上皮細胞 / サイトカイン Less

New understanding of the immune mechanism of sublingual immunotherapyPrincipal Investigator
- Principal Investigator
  
  清水猛史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shiga University of Medical Science
A mechanism of sublingual immunotherapy with Japanese cedar extract for the treatment of patients with Japanese cedar and cypress pollinosisPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKESHI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shiga University of Medical Science
Elucidation of the pathophysiology of eosinophilic chronic rhinosinusitis focusing on the action of coagulation factors on fibroblasts and eosinophils
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Tissue remodering of eosinophilic chronic rhinosinusitisPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKESHI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Efficacy of clarithromycin against avian influenza A virus
- Principal Investigator
  
  ARIKATA MASAHIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodelingPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKESHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
The role of epithelial derived cytokines (TSLP, IL-25,IL-33) in the airway diseases
- Principal Investigator
  
  KOUZAKI Hideaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Role of lipoxin as an inhibitory mediator in upper airway inflammationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Remodeling of the nose and the paranasal sinuses under diseased conditions
- Principal Investigator
  
  MAJIMA Yuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Prostaglandin E_2 inhibits airway inflammationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
  Mie University
MECHANISMS OF PROLIFERATION AND DIFFERENTIATION OF AIRWAY GLANDS
- Principal Investigator
  
  MAJIMA Yuichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Secretory cell differentiation and mucus secretion in cultures of human nasal epithelial cells.Principal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
The study of mucus hypersecretion in respiratory glands.
- Principal Investigator
  
  MAJIMA Yuichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Monoclonal antibodies as probes for studying human nasal secretionsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
鼻粘膜上皮の杯細胞化生に関する研究-エンドトキシンを利用した動物モデル作成と細胞特異的分化マーカーと免疫組織化学法を用いた病態の解明-Principal Investigator
- Principal Investigator
  
  清水猛史
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University

[Book] Recent Advances in Rhinosinusitis and Nasal Polyposis2015
- Author(s)
  Shimizu T, Shimzu S, Ogawa T, Takezawa K, Kouzaki H
- Publisher
  Kugler Publications, Amsterdam
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites2023
- Author(s)
  Murao Takuya、Kouzaki Hideaki、Arai Hiroyuki、Matsumoto Koji、Nakamura Keigo、Kawakita Kento、Tojima Ichiro、Shimizu Shino、Yuta Atsushi、Shimizu Takeshi
- Journal Title
  
  International Forum of Allergy & Rhinology
  
  Volume: 14 Issue: 1 Pages: 57-67
- DOI
  10.1002/alr.23221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24492
[Journal Article] CLINICAL EFFICASY OF HOUSE DUST MITE SUBLINGUAL IMMUNOTHERAPY WITH MITICURE® TABLETS IN 115 PAITENTS FOR 3 YEARS2023
- Author(s)
 湯田厚司、小川由起子、神前英明、清水猛史
- Journal Title
 
 Japanese Journal of Allergology
 
 Volume: 72 Issue: 3 Pages: 273-280
- DOI
 10.15036/arerugi.72.273
- ISSN
 0021-4884, 1347-7935
- Language
 Japanese
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23K24492
[Journal Article] Sublingual immunotherapy decreases the avidity of antigen‐specific IgE in patients with Japanese cedar pollinosis2023
- Author(s)
  Nakamura Keigo、Kouzaki Hideaki、Murao Takuya、Kawakita Kento、Arai Hiroyuki、Matsumoto Koji、Kubo Yoshihito、Tojima Ichiro、Shimizu Shino、Ogawa Yukiko、Yuta Atsushi、Sakai Rika、Ohno Hitoshi、Kido Hiroshi、Shimizu Takeshi
- Journal Title
  
  Allergy
  
  Volume: 78 Issue: 12 Pages: 3268-3271
- DOI
  10.1111/all.15900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24492
[Journal Article] CLINICAL EFFICACY OF SUBLINGUAL IMMUNOTHERAPY WITH CEDAR POLLEN IN A YEAR OF MASSIVE CEDAR POLLEN DISPERSAL AND ITS EFFECT ON JAPANESE CYPRESS POLLINOSIS2023
- Author(s)
  湯田厚司、小川由起子、神前英明、清水猛史
- Journal Title
  
  Japanese Journal of Allergology
  
  Volume: 72 Issue: 10 Pages: 1230-1239
- DOI
  10.15036/arerugi.72.1230
- ISSN
  0021-4884, 1347-7935
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24492
[Journal Article] CROSSTALK BETWEEN INNATE AND ACQUIRED IMMUNITY IN ALLERGEN IMMUNOTHERAPY2022
- Author(s)
  神前英明、中村圭吾、湯田厚司、清水猛史
- Journal Title
  
  Japanese Journal of Allergology
  
  Volume: 71 Issue: 10 Pages: 1207-1210
- DOI
  10.15036/arerugi.71.1207
- ISSN
  0021-4884, 1347-7935
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24492
[Journal Article] Sublingual immunotherapy with Japanese cedar pollen extract induces apoptosis of memory CD4 + T cells2022
- Author(s)
 Arai Hiroyuki、Kouzaki Hideaki、Murao Takuya、Nakamura Keigo、Kawakita Kento、Matsumoto Koji、Kikuoka Hirotaka、Yuta Atsushi、Shimizu Takeshi
- Journal Title
 
 Clinical & Experimental Allergy
 
 Volume: 52 Issue: 8 Pages: 974-978
- DOI
 10.1111/cea.14183
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23K24492
[Journal Article] ENHANCED CLINICAL EFFECTS OF CEDARCURE® TABLETS OF SUBLINGUAL IMMUNOTHERAPY OVER THE YEARS OF TREATMENT AND THE IMPACT OF OUTCOME BY COMBINED USE OF MITE SUBLINGUAL IMMUNOTHERAPY (DUAL SLIT) FOR JAPANESE CEDAR POLLINOSIS2022
- Author(s)
 湯田厚司、小川由起子、村尾拓哉、神前英明、清水猛史
- Journal Title
 
 Japanese Journal of Allergology
 
 Volume: 71 Issue: 9 Pages: 1122-1128
- DOI
 10.15036/arerugi.71.1122
- ISSN
 0021-4884, 1347-7935
- Language
 Japanese
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23K24492
[Journal Article] Anti-inflammatory roles of interleukin-35 in the pathogenesis of Japanese cedar pollinosis2021
- Author(s)
  Kouzaki Hideaki、Arai Yukihiro、Nakamura Keigo、Murao Takuya、Tojima Ichiro、Shimizu Shino、Yuta Atsushi、Shimizu Takeshi
- Journal Title
  
  Asia Pacific Allergy
  
  Volume: 11 Issue: 3 Pages: 1-10
- DOI
  10.5415/apallergy.2021.11.e34
- NAID
  120007161278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03802
[Journal Article] Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in patients with combined Japanese cedar and Japanese cypress pollinosis2020
- Author(s)
  Kikuoka Hirotaka、Kouzaki Hideaki、Matsumoto Koji、Arai Hiroyuki、Yamamoto Sayuri、Tojima Ichiro、Shimizu Shino、Miyashita Hiromi、Ogawa Yukiko、Osada Toshihiro、Okano Mitsuhiro、Yuta Atsushi、Shimizu Takeshi
- Journal Title
  
  Clinical Immunology
  
  Volume: 210 Pages: 108310-108310
- DOI
  10.1016/j.clim.2019.108310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16908, KAKENHI-PROJECT-19H03802, KAKENHI-PROJECT-18K16883
[Journal Article] Dynamic change of anti‐inflammatory cytokine IL‐35 in allergen immune therapy for Japanese cedar pollinosis2019
- Author(s)
  Kouzaki Hideaki、Arikata Masahiko、Koji Matsumoto、Arai Hiroyuki、Yamamoto Sayuri、Kikuoka Hirotaka、Fujimoto Noriki、Ogawa Yukiko、Yuta Atsushi、Shimizu Takeshi
- Journal Title
  
  Allergy
  
  Volume: 00 Issue: 4 Pages: 1-3
- DOI
  10.1111/all.14124
- NAID
  120006777345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03802
[Journal Article] The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways2018
- Author(s)
  Shimizu Shino, Takezawa-Yasuoka Kumiko, Ogawa Takao, Tojima Ichiro, Kouzaki Hideaki, Shimizu Takeshi
- Journal Title
  
  Clinical Immunology
  
  Volume: 188 Pages: 1-6
- DOI
  10.1016/j.clim.2017.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20200, KAKENHI-PROJECT-16K11212
[Journal Article] Thrombin and activated coagulation factor X stimulate the release of cytokines and fibronectin from nasal polyp fibroblasts via protease-activated receptors2017
- Author(s)
  Shimizu S, Tojima I, Takezawa K, Matsumoto K, Kouzaki H, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 31 Issue: 1 Pages: 13-18
- DOI
  10.2500/ajra.2017.31.4400
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462581, KAKENHI-PROJECT-16K11212, KAKENHI-PROJECT-15K20200
[Journal Article] 難治性上気道炎症に対する新たな局所治療薬としてのEpidermal growth factor(EGF)受容体阻害薬の可能性2016
- Author(s)
  竹澤公美子、小河孝夫、清水志乃、清水猛史
- Journal Title
  
  耳鼻免疫アレルギー
  
  Volume: ３４ Pages: 1-7
- NAID
  130005141309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion in airway epithelialium2016
- Author(s)
  Takezawa K, Ogawa T, Shimizu S, Shimizu T
- Journal Title
  
  Ａｍ　Ｊ　Ｒｈｉｎｏｌ　Ａｌｌｅｒｇｙ
  
  Volume: ３０ Issue: 1 Pages: 1-6
- DOI
  10.2500/ajra.2016.30.4263
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] 難治性上気道炎症に対する新たな局所治療薬としてのEpidermal growth factor (EGF)受容体阻害薬の可能性2016
- Author(s)
  竹澤公美子、小河孝夫、清水志乃、清水猛史
- Journal Title
  
  耳鼻免疫アレルギー
  
  Volume: ３４ Pages: 1-7
- NAID
  130005141309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhinosinusitis2016
- Author(s)
  Shimizu T, Shimizu S, Ogawa T, Takezawa K, Kouzaki H
- Journal Title
  
  Recent advances in thinosinusitis and nasal polyposis
  
  Volume: 0 Pages: 111-116
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in tissue remodeling2014
- Author(s)
  Shimizu S, Kouzaki H, Ogawa T, Takezaka K, Tojima I, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 28 Pages: 103-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] Eosinophil epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling2014
- Author(s)
  Shimizu S, Kouzaki H, Ogawa T, Takezawa K, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 28 Issue: 2 Pages: 103-109
- DOI
  10.2500/ajra.2014.28.4018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23592509, KAKENHI-PROJECT-24791770, KAKENHI-PROJECT-26462581
[Journal Article] Transcription of interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells2013
- Author(s)
  Kouzaki H, Tojima I, Kita H, Shimizu T
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: in press Issue: 5 Pages: 741-750
- DOI
  10.1165/rcmb.2012-0304oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791594
[Journal Article] 好酸球性副鼻腔炎の疑問-ニカワ様鼻汁の本態は何か?好酸球は何をしているのか?2012
- Author(s)
  清水猛史
- Journal Title
  
  耳鼻臨床
  
  Volume: 105 Pages: 803-812
- NAID
  10031012193
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] 免疫アレルギー学の最前線 IL-25 誘導によるアレルギー性炎症2012
- Author(s)
  神前英明、清水猛史
- Journal Title
  
  耳鼻咽喉科免疫アレルギー
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791594
[Journal Article] Interleukin-25 induces allergic inflammation2012
- Author(s)
  神前英明、清水猛史
- Journal Title
  
  Journal of Japan Society of Immunology & Allergology in Otolaryngology
  
  Volume: 30 Issue: 3 Pages: 237-242
- DOI
  10.5648/jjiao.30.237
- NAID
  10031163497
- ISSN
  0913-0691, 2185-5900
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791594
[Journal Article] 好酸球性副鼻腔炎の疑問－ニカワ様鼻汁の本態は何か？好酸球は何をしているのか？2012
- Author(s)
  清水猛史
- Journal Title
  
  耳鼻臨床
  
  Volume: 105 Pages: 803-812
- NAID
  10031012193
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] 上皮細胞から放出される IL-33 とその役割2011
- Author(s)
  神前英明, 紀太博仁, 清水猛史
- Journal Title
  
  日本鼻科学会会誌
- NAID
  130004546071
- URL
  http://dx.doi.org/10.7248/jjrhi.50.46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791594
[Journal Article] Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats.2009
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Journal Title
  
  Ann Otol Rhinol Laryngol 118
  
  Pages: 536-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats2009
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Journal Title
  
  Ann Otol Rhinol Laryngol 118
  
  Pages: 536-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] EP4 agonist inhibits lipopolysaccharide-induced mucus secretion in airway epithelial cells.2008
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Journal Title
  
  Ann Otol Rhinol Laryngol 117
  
  Pages: 51-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] EP4 agonist inhibits lipopolysaccharide-induced mucus secretion in airway epithelial cells2008
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Journal Title
  
  Ann Otol Rhinol Laryngol 117
  
  Pages: 51-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells.2003
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Am J Respir Grit Med 168
  
  Pages: 581-587
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390516
[Journal Article] A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium of sensitized rats.2003
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  J Allergy Clin Immunol 112
  
  Pages: 119-125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390516
[Journal Article] In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells.2003
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Am J Respir Crit Med 168
  
  Pages: 581-587
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390516
[Journal Article] 上気道炎症におけるリポキシンの役割
- Author(s)
  清水志乃、星恵理子、神前英明, 他
- Journal Title
  
  耳鼻免疫アレルギー(JJIAO)
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] 上気道炎症におけるリポキシンの役割
- Author(s)
  清水志乃、星恵理子、神前英明、清水猛史
- Journal Title
  
  耳鼻免疫アレルギー(JJIAO) 印刷中
- Data Source
  KAKENHI-PROJECT-20591999
[Patent] 採取パーツと採取パーツを備える生体組織採取具2014
- Inventor(s)
  南條俊文、福原崇臣、濱中健一、遠山育夫、清水志乃
- Industrial Property Rights Holder
  パナソニックヘルスケア株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-011126
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462663
[Patent] 生体組織採取器具2014
- Inventor(s)
  森分優太、篠原紀行、南條俊文、濱中健一、遠山育夫、清水志乃等
- Industrial Property Rights Holder
  パナソニックヘルスケア株式会社
- Industrial Property Rights Type
  意匠
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462663
[Presentation] ダニ舌下免疫療法115例の3年間の治療成績2024
- Author(s)
  湯田厚司、小川由起子、神前英明、清水猛史
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] New understanding of the immune mechanism of sublingual innunotherapy2024
- Author(s)
  Shimizu T
- Organizer
  日韓耳鼻咽喉科学会2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] A Transcription Factor Blimp1 in CD4 + T cells Promotes Type 2 Immune Responses in the Lungs While it Suppresses IgE Antibody Production in Mice2023
- Author(s)
  Koji Matsumoto, HIrohito Kita, Takeshi Shimizu
- Organizer
  IFOS DUBAI ENT WORLD CONGRESS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] Role of infiltrating eosinophils in pathophysiology of CRS2023
- Author(s)
  Takeshi Shimizu
- Organizer
  IFOS DUBAI ENT WORLD CONGRESS 2023
- Invited
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] ダニ舌下免疫療法における濾胞性制御性T細胞の増加と臨床症状スコアの関連について2023
- Author(s)
  村尾拓哉、神前英明、湯田厚司、清水猛史
- Organizer
  第71回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] 上気道炎症の病態と制御ー臨床における疑問に挑むー2023
- Author(s)
  清水猛史
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] 舌下免疫療法における濾胞性制御性T細胞の変化と臨床症状スコアについて2022
- Author(s)
  村尾拓哉、神前英明、湯田厚司、清水猛史
- Organizer
  村尾拓哉、神前英明、湯田厚司、清水猛史
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] 抗原特異的IgE抗体の抗原親和性からみた舌下免疫療法の新たな作用機序2022
- Author(s)
  中村圭吾、神前英明、坂井利香、湯田厚司、木戸博、清水猛史
- Organizer
  第2回日本耳鼻咽喉科免疫アレルギー感染症学会
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] シダキュア錠1-3年目治療例の2022年治療成績とDual SLITが花粉期成績に及ぼす影響2022
- Author(s)
  湯田厚司、村尾拓哉、清水猛史
- Organizer
  第61回日本鼻科学会
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] アレルゲン免疫療法の進歩2021
- Author(s)
  神前英明、湯田厚司、清水猛史
- Organizer
  第122回日本耳鼻咽喉科頭頸部外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] 上気道炎症の業態とその制御-臨床における疑問とその解明2021
- Author(s)
  清水猛史
- Organizer
  第60回日本鼻科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] アレルゲン免疫療法の進歩2021
- Author(s)
  神前英明、湯田厚司、清水猛史
- Organizer
  第122回日本耳鼻咽喉科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ花粉舌下免疫療法によるMemory CD4+T細胞のアポトーシス誘導2021
- Author(s)
  新井宏幸、神前英明、中村圭吾、村尾拓哉、湯田厚司、清水猛史
- Organizer
  第122回日本耳鼻咽喉科学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] アレルゲン免疫療法のメカニズム解明へのアプローチ2021
- Author(s)
  神前英明、菊岡弘高、新井、湯田厚司、清水猛史
- Organizer
  第1回耳鼻咽喉科免疫アレルギー感染症学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ花粉舌下免疫療法によるメモリーCD4+T細胞のアポトーシス誘導2021
- Author(s)
  新井宏幸、神前英明、中村圭吾、村尾拓哉、湯田厚司、清水猛史
- Organizer
  第122回日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ花粉舌下免疫療法における制御性B細胞によるメモリーTh2細胞、Tfh2細胞のアポトーシス誘導2021
- Author(s)
  新井宏幸、神前英明、村尾拓哉、中村圭吾、湯田厚司、清水猛史
- Organizer
  第60回日本鼻科学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] Sublingual immunotherapy with Japanese cedar pollen extract induces apoptosis of memory CD4+ T cells2020
- Author(s)
  Hiroyuki Arai, Hideaki Kouzaki, Atsushi Yuta, Takeshi Shimizu
- Organizer
  JSA/WAO Joint Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ花粉舌下免疫療法におけるメモリーCD4+T細胞のアポトーシス2020
- Author(s)
  新井宏幸、神前英明、湯田厚司、清水猛史
- Organizer
  第38回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] Future prediction of Japanese cedar (JC) and Japanese cypress pollen scattering and the immunological effects of sublingual immunotherapy with JC pollen extracts for the treatment of combined JC and Japanese cypress pollinosis2019
- Author(s)
  Takeshi Shimizu
- Organizer
  5th Rhinology Research Forun in Asia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ・ヒノキ花粉症患者におけるスギ花粉症舌下免疫療法のヒノキ花粉症に対する免疫学的作用2019
- Author(s)
  菊岡弘高、神前英明、松本晃治、戸嶋一郎、清水志乃、長田年弘、岡野光博、湯田厚司、清水猛史
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ・ヒノキ花粉症患者におけるスギ花粉症舌下免疫療法のヒノキ花粉症に対する免疫学的作用2019
- Author(s)
  菊岡弘高、神前英明、松本晃治、戸嶋一郎、清水志乃、長田年弘、岡野光博、湯田厚司、清水猛史
- Organizer
  第1回日本アレルギー学会地方会近畿支部学術講演会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] 上気道炎症における組織リモデリングとその制御2018
- Author(s)
  清水志乃
- Organizer
  第67回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of eosinophils in pathophysiology of eosinophilic CRS2017
- Author(s)
  Takeshi Shimizu
- Organizer
  The 9th annual meeting of the Thai Rhinologic Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of infiltrating eosinophils in pathophysiology of CRS2017
- Author(s)
  Takeshi Shimizu
- Organizer
  Rhinology World Congress Hong Kong
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion and neutrophil infiltration in airway epithelium2016
- Author(s)
  Takezawa K, Ogawa T, Shimizu S, ShimizuT
- Organizer
  35th Congress of the International Society of Inflammation & Allergy of the Nose
- Place of Presentation
  Stockholm
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] 上気道炎症の組織リモデリングにおける凝固系因子と好酸球の役割2016
- Author(s)
  清水志乃
- Organizer
  日本鼻科学会
- Place of Presentation
  宇都宮市
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of EGFR in upperairway inflammation2016
- Author(s)
  Shimizu T
- Organizer
  2nd Rhinology Research Forum in Asia
- Place of Presentation
  Singapore
- Year and Date
  2016-12-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Eosinophil-epithelial cell interaactions stimulate the production of MUC5AC mucin and profibrotic cytokines through the transactivation of epidermal growth factor receptor in airway epithelial cells2015
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  16th World Congress of Rhinology
- Place of Presentation
  San Paulo, Brazil
- Year and Date
  2015-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2015
- Author(s)
  Shimizu T
- Organizer
  17th Asian Research Symposium in Rhinology
- Place of Presentation
  Beijing, China
- Year and Date
  2015-04-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Our research interests and pathogenesis of eosinophilic chronic rhinosinusitis2015
- Author(s)
  Shimizu T
- Organizer
  11th Research Symposium on Human Natural Defense System
- Place of Presentation
  Seoul, Korea
- Year and Date
  2015-10-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Interaction between coagulation and upper airway inflammation2015
- Author(s)
  Shimizu T
- Organizer
  13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2015-12-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Tsissue remodeling of eosinophil-associated chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  Kyung Hee International Rhinologic Symposium 2013
- Place of Presentation
  Seoul, South Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhunosinusitis2013
- Author(s)
  Shimizu T, Shimizu S, Ogawa T, Takezawa K, Kouzaki H
- Organizer
  VIIInternational Syumposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
- Place of Presentation
  Matsue
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Transcription of Interleukin-25 and Extracellular Release of the Protein Is Regulated by Allergen Proteases in Airway Epithelial Cells2013
- Author(s)
  Kouzaki H, Tojima I, Kita H, Shimizu T
- Organizer
  AAAAI 2013 Annual Meeting
- Place of Presentation
  USA
- Year and Date
  2013-02-25
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  The 12th Taiwan-Japan conference on Otolaryngology-Head and Neck Surgery
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
 Shimizu T, Shimizu S
- Organizer
 The 12^<th> Taiwan-Japan Conference on Otolarynggology-Head and Neck Surgery
- Place of Presentation
 Taipei
- Data Source
 KAKENHI-PROJECT-23592509
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  16th Asian Research Symposium in Rhinology
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Symposium, Up-to-date Research in CRS : Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
 Shimizu T, Shimizu S
- Organizer
 16^<th> Asian Research Symposium in Rhinology
- Place of Presentation
 Tokyo
- Data Source
 KAKENHI-PROJECT-23592509
[Presentation] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  VII International symposium on recent advances in rhinosinusitis and nasal polyposis
- Place of Presentation
  Matsue, Shimane
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 粘液・サイトカイニン分泌における好酸球と上皮細胞の交互作用2012
- Author(s)
  清水志乃、清水猛史
- Organizer
  アレルギー・好酸球研究会2012
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] プロテアーゼは気道上皮細胞において PAR-2 受容体を介して IL-25 産生を誘導する2012
- Author(s)
  神前英明、戸嶋一郎、紀太博仁、清水猛史
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  滋賀
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 粘液・サイトカイン分泌における好酸球と上皮細胞の相互作用2012
- Author(s)
  清水志乃、清水猛史
- Organizer
  アレルギー・好酸球研究会2012
- Place of Presentation
  東京
- Year and Date
  2012-06-23
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 粘液・サイトカイン分泌における好酸球と上皮細胞の相互作用2012
- Author(s)
  清水志乃、神前英明、清水猛史
- Organizer
  第31回気道分泌研究会
- Place of Presentation
  東京
- Year and Date
  2012-04-07
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 気道上皮細胞と好酸球の相互作用による粘液・サイトカイン分泌2012
- Author(s)
  清水志乃、神前英明、清水猛史
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大津市
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Eosinophil- epithelial cell interaction enhances mucin production and tissue remodeling2012
- Author(s)
 Shimizu S, Kouzaki H, Shimizu T
- Organizer
 The 14^<th> Japan-Korea Joint Meeting of Otorhinolaryngology -Head and Neck Surgery
- Place of Presentation
 Kyoto
- Data Source
 KAKENHI-PROJECT-23592509
[Presentation] 抗原暴露による上皮細胞にけるIL-25誘導のメカニズム2012
- Author(s)
  神前英明、戸嶋一郎、紀太博仁、清水猛史
- Organizer
  第62回日本アレルギー学会秋季学術大会
- Place of Presentation
  大阪
- Year and Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] Eosinophil-epithelial cell interaction enhances mucin production and tissue remodeling2012
- Author(s)
  Shino Shimizu, Hideaki Kouzaki, Takeshi Shimizu
- Organizer
  The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Place of Presentation
  ソウル、大韓民国
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 副鼻腔粘膜上皮細胞からみた好酸球性副鼻腔炎2012
- Author(s)
  神前英明、清水志乃、清水猛史
- Organizer
  第51回日本鼻科学会
- Place of Presentation
  千葉
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 空中アレルゲンはATP を介してIL-33 を放出させ、Th2 タイプの自然免疫反応を引き起こす2011
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  第29回日本耳鼻咽喉科免疫アレルギ-学会
- Place of Presentation
  大分
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 上皮細胞から放出されるIL-33とその役割2011
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  第41回日本職業・環境アレルギー学会
- Place of Presentation
  名古屋
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 空中アレルゲンはATP を介してIL-33 を放出させ、Th2 タイプの自然免疫反応を引き起こす2011
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 上気道炎症におけるリポキシンの役割2011
- Author(s)
  清水志乃、星恵理子、神前英明、清水猛史
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大分市
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-20591999
[Presentation] 上気道炎症におけるリポキシンの役割2011
- Author(s)
  清水志乃、星恵理子、神前英明, 他
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  全日空ホテルオアシスタワー(大分市)
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-20591999
[Presentation] 気道上皮細胞由来の IL-33 の放出とその役割2010
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  気道上皮細胞由来の IL-33 の放出とその役割
- Place of Presentation
  札幌
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 気道上皮細胞由来のIL-33 の放出とその役割2010
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  第60回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] Role of Prostaglandin E2 as a protective mediator for airway inflammation.2008
- Author(s)
 Hattori R, Shimizu S, Majima Y, Shimizu T
- Organizer
 13^<th> Asian Research Symposium in Rhinology
- Place of Presentation
 Bankok, Thailand
- Year and Date
 2008-11-20
- Data Source
 KAKENHI-PROJECT-20591999
[Presentation] Prostaglandin E2 receptor (EP)agonists inhibit antigen-Induced mucus production and eosinophil infiltration in ratnasal epithelium2008
- Author(s)
 Shimizu T, Hattori R Shimizu S, Majima Y
- Organizer
 The 27^<th> international symposium of Infection and allergy of the nose
- Place of Presentation
 Crete, Greece
- Year and Date
 2008-06-17
- Data Source
 KAKENHI-PROJECT-20591999
[Presentation] Role of prostaglandin E2 as a protective mediator for airway inflammation2008
- Author(s)
 Shimizu T
- Organizer
 The 13^<th> asian research symposium in rhinology
- Place of Presentation
 Bankok, Thailand
- Year and Date
 2008-11-21
- Data Source
 KAKENHI-PROJECT-20591999
[Presentation] Prostaglandin E2 receptor agonists inhibit antigen-induced mucus production and eosinophil infiltration in rat nasal epithelium.2008
- Author(s)
 Shimizu T, Hattori R, Shimizu S, Majima Y
- Organizer
 27^<th> International Symposium of Infection & Allergey of the Nose
- Place of Presentation
 Crete, Greece
- Year and Date
 2008-06-17
- Data Source
 KAKENHI-PROJECT-20591999
[Presentation] 気道上皮細胞と好酸球の相互作用による粘液・サイトカイン分泌
- Author(s)
  清水志乃、小河孝夫、戸嶋一郎、神前英明、清水猛史
- Organizer
  第112回日本耳鼻咽喉科学会学術講演会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Mucus hypersecretion in the pathogenesis of upper airway inflammation; its merits and demerits
- Author(s)
  Shimizu T
- Organizer
  10th Research Symposium on Human Natural Defense System
- Place of Presentation
  Seoul, Republic of Korea
- Year and Date
  2014-10-18 – 2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] ROle of eosinophils in tissue remodeling of chronic rhinosinusitis
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  32nd International Symposium of Infection & Allergy of Nose
- Place of Presentation
  Amsterdam, Kingdom of the Netherlands
- Year and Date
  2014-06-22 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-26462581

1. KOUZAKI Hideaki (50505592)

# of Collaborated Projects: 5 results

# of Collaborated Products: 84 results
2. KOUZAKI Hideaki (10402710)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TOJIMA Ichiro (80567347)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
4. MAJIMA Yuichi (60024791)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. YUTA Atsushi (80293778)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
6. OGAWA Takao (90549908)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. SAKAKURA Yasuo (40024723)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 新井宏幸 (60816627)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. SENO Satoshi (90378464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIBAYAMA Masayuki (20402711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HOSHI Eriko (20467385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. TOOYAMA Ikuo (20207533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ARIKATA MASAHIKO (50634383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HARADA Teruhiko (20183569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKEUCHI Kazuhiko (50206942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 安岡公美子 (80711837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山本小百合 (10828114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 中多祐介 (80794958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 松本晃治 (40750138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. 中村圭吾 (50848380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
21. 川北憲人 (50915121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. KITA Hirohito

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
23. 竹澤公美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU Takeshi 清水 猛史

Research Projects

Research Products

Co-Researchers

New understanding of the immune mechanism of sublingual immunotherapyPrincipal Investigator

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A mechanism of sublingual immunotherapy with Japanese cedar extract for the treatment of patients with Japanese cedar and cypress pollinosisPrincipal Investigator

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Elucidation of the pathophysiology of eosinophilic chronic rhinosinusitis focusing on the action of coagulation factors on fibroblasts and eosinophils

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Tissue remodering of eosinophilic chronic rhinosinusitisPrincipal Investigator

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Efficacy of clarithromycin against avian influenza A virus

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Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease

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Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodelingPrincipal Investigator

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The role of epithelial derived cytokines (TSLP, IL-25,IL-33) in the airway diseases

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Role of lipoxin as an inhibitory mediator in upper airway inflammationPrincipal Investigator

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Remodeling of the nose and the paranasal sinuses under diseased conditions

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Prostaglandin E_2 inhibits airway inflammationPrincipal Investigator

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MECHANISMS OF PROLIFERATION AND DIFFERENTIATION OF AIRWAY GLANDS

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Secretory cell differentiation and mucus secretion in cultures of human nasal epithelial cells.Principal Investigator

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SHIMIZU Takeshi 清水猛史