Tooyama Ikuo 遠山育夫

… Alternative Names

TOOYAMA Ikuo 遠山育夫

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Researcher Number	20207533
Other IDs
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Affiliation (Current)	2025: 滋賀医科大学, 医学部, 理事
Affiliation (based on the past Project Information) *help	2020 – 2024: 滋賀医科大学, 医学部, 理事 2015 – 2019: 滋賀医科大学, 神経難病研究センター, 教授 2004 – 2015: 滋賀医科大学, 分子神経科学研究センター, 教授 2005: Shiga University of Medical Science, Faculty of Medicine, Professor, 医学部, 教授 2004: 国立大学法人滋賀医科大学, 医学部, 教授 … More 2003: 滋賀医科大学, 医学部, 教授 2002: 滋賀医科大学, 分枝神経科学研究センター, 教授 1999 – 2002: Shiga University of Medical Science, Inst. of Molecular Neurobiology, Professor, 分子神経科学研究センター, 教授 1999 – 2000: 滋賀医科大学, 医学部, 教授 1995 – 1998: 滋賀医科大学, 分子神経生物学研究センター, 助教授 1995: Shiga University of Medical Science, Molecular Neurobiology Research Center, Ass, 分子生物学研究センター, 助教授 1995: Inst.of Molecular Neurobiology Assistant Professor, 分子神経生物學研究センター, 助教授 1994: 滋賀医科大学, 分子神経生物学研究センター, 助手 1989 – 1992: SHIGA UNIV. OF MEDICAL SCIENCE, DIV. OF NEUROANATOMY, ASSISTANT, 分子神経生物学研究センター, 助手 1988: 滋賀医大, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Biological Sciences / Biomedical engineering/Biological material science / Basic Section 90110:Biomedical engineering-related / Medium-sized Section 46:Neuroscience and related fields / Nerve anatomy/Neuropathology / Neurology / General anatomy (including Histology/Embryology) / Neurochemistry/Neuropharmacology / Experimental pathology / Neuroscience in general … More Except Principal Investigator … More General anatomy (including Histology/Embryology) / Nerve anatomy/Neuropathology / Otorhinolaryngology / Digestive surgery / Otorhinolaryngology / Human genetics / Medium-sized Section 38:Agricultural chemistry and related fields / Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Hygiene and public health / Radiation science / Biomedical engineering/Biomaterial science and engineering / 神経解剖学 / Urology / Public health/Health science / Psychiatric science / Biomedical engineering/Biological material science Less
Keywords	Principal Investigator アルツハイマー病 / 診断 / 核磁気共鳴画像 / 認知症 / 神経科学 / alternative splicing / 脳神経疾患 / ベータアミロイド / タウタンパク / アミロイドオリゴマー … More / 治療 / 診断薬 / mRNA / FGF / タウ / memory / learning / acetylcholine / 記憶 / 学習 / アセチルコリン / 神経化学 / 神経変性疾患 / 核磁気共鳴医学 / 画像診断 / 分子イメージング / 非ヒト霊長類モデル / アミロイド / 組織細胞化学 / プリオン / AI / タウプロテイン / 脳神経 / antibody / cholinergic neurons / alternative splicin / 抗体 / コリン作動性神経 / choinesterase inhibitor / neurotransmitter / Alzheimer's disease / コリンエステラーゼ阻害薬 / コリンエストラーゼ阻害薬 / 神経伝達物質 / adrenal gland / hormone / receptor / Acidic fibroblast growth factor / 免疫組織化学 / PCR / 副腎 / ホルモン / 受容体 / 酸性線維芽細胞成長因子 / 神経病理 / 鼻粘膜 / 老化 / オリゴマー / 血液 / 体外診断 / フッ素 / MR画像 / 超常磁性酸化鉄 / フッ素MR画像法 / 核磁気共鳴 / パーキンソン病 / 疾患モデル動物 / 核移植 / 疾患モデル / ES細胞 / トランスジェニック動物 / 一酸化窒素合成酵素 / 脳機能解析法 / 核移行シグナル / 転写因子 / 神経細胞死 / トランスフェクション / ペプチド核酸 / 一酸化窒素 / アンチセンス … More Except Principal Investigator 免疫組織化学 / mRNA / RT-PCR / アルツハイマー病 / 有機化学 / CNP / バソプレッシン / メニエール病 / immunohistochemistry / c-fos / ラット / vasopressin / cDNA / Immunohistochemistry / コリン神経 / コリンアセチル基転移酵素 / アミロイドβ / 核酸 / 毒性オリゴマー / 抗毒性ターン特異抗体 / 認知症 / 脳神経疾患 / アセチルコリン / 水代謝 / 内耳 / endolymphatic hydrops / Meniere's disease / inner ear / molecular biology / 内リンパ水腫 / 分子生物学 / rat brain / 抗利尿ホルモン / ラット脳 / 敗血症性脳症 / 上腸間膜動脈閉塞症 / 脳 / PCR法 / in situハイブリダイゼーション / Cholinergic / 疫学 / ホスホロチオエート・オリゴ / バゾプレッシン / 毒性配座特異抗体 / 抗毒性ターン抗体 / 毒性立体配座 / ジスルフィド結合 / オリゴマー / 分子内ジスルフィド結合 / 抗Aβ42毒性配座特異抗体 / 抗体 / ２量体 / ジスルフィド架橋 / 分子内ジスルフィド架橋 / メタボローム / メタボロミクス / 疫学研究 / 予防 / 脳萎縮 / 一般女性 / 女性 / 動脈硬化 / 13C-MR / アルツハイマーモデル / １３C-NMR / 13C-NMR / グルコース代謝 / 脳代謝画像 / APPマウス / 末梢神経疾患 / 末梢神経 / ミトコンドリア / 人類遺伝学 / 診断薬 / 核磁気共鳴画像 / 神経科学 / Antigen preparation / Cholinergic system / Brain / Antibody to acetylcholine / 免疫組織学 / コリン神経系 / アセチルコリン抗体 / Acetylcholine / Vasopressin / Meniere disease / regulation system of inner ear fluid / Inner ear / アクアポリン / Alternative splicing / Adenosine deaminase / Histidine decarboxylase / Colooalization / Neurotransmitter / Hypothalamus / 遺伝子発現 / スプライシング / 隆起乳頭体核 / アデノシンデアミネース / ヒスチジン脱炭酸酵素 / 共存 / 神経伝達物質 / 視床下部 / コリン作動性 / vertigo / Water regulation / バソプレシン / 神経ペプチド / 内耳水代謝 / めまい / バンプレッシン / メニニール病 / phosphorylated c-Jun / c-Jun / c-Fos / systemic inflammatory response syndrome / CLP / Rat / SIRS / CNS / c-fos、 / phosphorylated c-jun / c-jun / parasympathetic nervous system / antisense oligonucleotide / retinal ganglion cells / cholinergic neurons / choline acetyltransferase / alternative splicing / MAP2 / 分子変換 / 脳機能解析 / 副交感神経 / アンチセンス・オリゴヌクレオチド / 網膜神経節細胞 / コリン作動性神経 / 選択的スプライシング / VIP / inner ear fluid regultion / オキシトシン / PCR / 利尿ホルモン / image analysis / histochemistry / primers / reverse transcription / PCR method / in situ hybrydization / 細胞 / 画像解核 / 組織固定 / 画像解析 / 組織化学 / プライマー / 逆転写 / endotoxin / occlusion of the superior mesenteric artery / エンドトキシン / c‐fos / opioid / dopaminergic / antibody / brain / polyclonal / monoclonal / deltorphine / 生後発達 / モノクローナル抗体 / 黒質線条体 / デルトルフィン / probe design / electron microscopy / in situ hybridization / quantitative image analysis / biotin phosphoramidite / in situハイブリダイゼ-ション / プロ-ブ / 自動合成機 / プローブ / ビオチン / Bile acids / Electron microscopy / Carbon tetrachloride / Mouse / Liver / Taurine antibody / Taurine / タウロコ-ル酸 / 胆汁酸 / 肝臓 / 電子顕微鏡 / 四塩化炭素 / マウス / 肝 / タウリン抗体 / タウリン / Glia / Senile plaque / Nitric oxide synthase / NADPH diaphorase / Fibroblast growth factor / Alzheimer's Disease / 老化 / 痴呆 / NADPHジアホラ-ゼ / アストログリア / FGF受容体 / bFGF / aFGF / FGF / アストロサイト / 老人斑 / 亜酸化窒素 / 成長因子受容体 / 線維芽細胞成長因子 / コリン神経脱落 / 痴呆症 / アルツハイマ-病 / バレル構造 / 体性運動野 / 視覚野 / 生後発育 / セロトニン / 神経回路 / 可塑性 / シナプス / 嗅粘膜 / タウ蛋白 / ヒト鼻腔 / 早期診断 / 下部尿路障害 / 脊髄グリア細胞 / 間質性膀胱炎 / 過活動膀胱 / 排尿学 / 下部尿路機能障害 / 発現制御 / 神経 / 遺伝子 / 転写障害 / 神経変性 / 転写因子 / 循環器・高血圧 / 循環器・高血圧疫学 / 潜在性動脈硬化 / 頭部MRI / コホート研究 / 脳卒中 / 循環器・高血圧・疫学 / 社会医学 / 総合失調症 / 再生医療 / 神経画像 / 神経幹細胞 / 動物モデル / 統合失調症 / 精神生理学 / HVJ-E / 超常磁性鉄 / 組胞画像 / 蛍光プローブ / 常時性鉄粒子 / 細胞標識 / 近赤外 / 蛍光 / ナノ粒子 / 分子イメージング / 幹細胞 / MRI / CRNA増幅法 / ポリチミジン・オリゴヌクレオテド / ホスホロチオエ-トオリゴ / バゾブレッシン / ポリチミジン・オリゴヌクレオチド / cRNA増幅法 / T7プロモーター / 脳機能解析法 / RNAポリメラーゼ / アンチセンスRNA Less

Simultaneous analysis of multiple abnormal brain proteins in Alzheimer's disease using multiple fluorine MR imagingPrincipal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Shiga University of Medical Science
Development to ultra-early diagnosis and prevention of AD by using a specific antibody against the toxic conformation of amyloid beta
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Doshisha University
  Kyoto University
Development of AI technology to detect prion activity of pathogenic proteins in nasal mucosa and its application to diagnosis of dementiaPrincipal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Shiga University of Medical Science
Epidemiological study of dementia related factors using metabolomics analysis in general Japanese men
- Principal Investigator
  
  Kadota Aya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Shiga University of Medical Science
Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kyoto University
Simultaneous analysis of Aβ oligomers, Aβ fibrils and phosphrylated tau protein using fluroine-MRIPrincipal Investigator
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Development novel probes for fluorine MRI to detect neurodegenerative diseases
- Principal Investigator
  
  Taguchi Hiroyasu
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shiga University of Medical Science
Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in COX6A1
- Principal Investigator
  
  Makino Satoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tohoku University
Subclinical atherosclerosis and brain atrophy in the general Japanese women
- Principal Investigator
  
  Miura Katsuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hygiene and public health
- Research Institution
  Shiga University of Medical Science
ケミカルシフトの違いを利用したフッ素MR画像による複数の脳内異常蛋白の同時解析Principal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Development of novel diagnostic and therapeutic methods on Alzheimer's disease by targeting amyloid oligomersPrincipal Investigator
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.Principal Investigator
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Study of a highly sensitive C-13 MR glucose metobolite mapping with the brain of an Altzheimer model mouse
- Principal Investigator
  
  Morikawa Shigehiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Shiga University of Medical Science
Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
フッ素ＭＲ画像法と光画像法によるアミロイドオリゴマーのｉｎ　ｖｉｖｏ病態解析Principal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
General transcription factor TAF1 is involved in transcriptional impairment and neurodegeneration
- Principal Investigator
  
  MAKINO Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tohoku University
  Yamagata University
Central sensitization mechanism depends on microglia participates in Lower Urinary Tract Symption
- Principal Investigator
  
  TSURU Teruhiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Shiga University of Medical Science
Comparison Western Japan with Eastern Japan about the cause of asymptomatic cerebrovascular disorders and hippocampal atrophy in general Japanese men
- Principal Investigator
  
  MIURA Katsuyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Shiga University of Medical Science
Development of hemodiagnostic methods for Alzheimer's disease using curcuimin derivativesPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Development of amyloid imaging using fluorine-MRIPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shiga University of Medical Science
Research on production of a primate model for schizophrenia and development of transplant therapy by neural stem cell grafts
- Principal Investigator
  
  MORI Norio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Hamamatsu University School of Medicine
Development of diagnostic methods for Parkinson disease using high fieled magnetic resonance imagingPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shiga University of Medical Science
ES細胞をししたアルツハイマー病モデルサルの作成Principal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Shiga University of Medical Science
Non-invasive MRI tracking of labeled stem cells and its application to regenerative medicine
- Principal Investigator
  
  INUBUSHI Toshiro
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shiga University of Medical Science
Novel cholineacetyltransferase variants (pChAT) in the brain of human and monkeyPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
A study for regulation of inner ear fluid using molecular biology metod
- Principal Investigator
  
  KITANO Hiroya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tottori University
Study on novel cholinergic pathways in the brain of patients with Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Shiga University of Medical Science
Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rats
- Principal Investigator
  
  KIMURA Hisoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
Localization of peptides that regulate inner ear fluid in the rat
- Principal Investigator
  
  KITANO Hiroya
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
神経細胞の核内転写因子の人工制御による脳機構の解明Principal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neuroscience in general
- Research Institution
  Shiga University of Medical Science
Studies on Neuronal mRNA Splicing
- Principal Investigator
  
  YASUHARA Osamu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
Study on the central nervous system of rat with systemic inflammatory response syndrome (SIRS)
- Principal Investigator
  
  HASE Takanori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shiga University of Medical Science
生体内増幅アンチセンスRNAを用いる脳機能解析法の開発
- Principal Investigator
  
  YASUHARA Osamu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
Expression of fluid regulation peptides in the inner ear.
- Principal Investigator
  
  KITANO Hiroya
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga Universityof Medical Science
Development of in situ PCR method and its application to histochemistry
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shiga University of Medical Science
Localization and function of acidic fibroblast growth factor in adrenal glandPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shiga University of Medical Science
Joint study on deltorphines in the mammalian brain
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Shiga University of Medical Science
"Expression of c-fos protein in rat brain after occlusion of superior mesenteric artery (immunohistochemical investigation)"
- Principal Investigator
  
  HASE Takanobu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shiga University of Medical Science
Non-radioactive in situ hybridization histochemistry using chemically defined boitin-labeled probes.
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shiga University of Medical Science(SUMS)
Molecular neurobiological study on the deterioration of specific genes for dementia of Alzheimer type
- Principal Investigator
  
  HIMURA Hiroshi
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Shiga University of Medical Science
Taurine Immunohistochemistry in the Liver
- Principal Investigator
  
  OCHI Junzo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shiga University of Medical Science
シナプス形成に関するモノアミン神経の機能形態学的研究
- Principal Investigator
  
  木村宏
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Shiga University of Medical Science
IMMUNOHISTOCHEMICAL STUDY OF THE CENTRAL CHOLINERGIC SYSTEM BY USING ANTIBODY TO ACETYLCHOLINE.
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  神経解剖学
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE

[Book] FRUITS, VEGETABLES AND HERBS: Bioactive Foods in Health Promotion2017
- Author(s)
  Ikuo Tooyama, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Hiroyasu Taguchi and Daijiro Yanagisawa
- Total Pages
  593
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-15K01282
[Book] Curcumin against amyloid pathology in mental health and brain composition.; In Health Fruits, Vegetables, and Herbs: Bioactive Foods in Promoting Edited by Ronald Watson and Victor Preedy2016
- Author(s)
  Ikuo Tooyama, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Hiroyasu Taguchi, Daijiro Yanagisawa
- Total Pages
  19
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26640042
[Book] FRUITS, VEGETABLES AND HERBS: Bioactive Foods in Health Promotion2016
- Author(s)
  Tooyama I, Ibrahim NF, Durani LW, Haemzah HS, Damanhuri MHA, Wan Ngah WZ, Taguchi H, Yanagisawa D
- Total Pages
  593
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26290022
[Book] 神経内科学テキスト改訂第2版(分担執筆)2005
- Author(s)
  遠山育夫
- Total Pages
  10
- Publisher
  南江堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes2024
- Author(s)
  Aldoghachi Asraa Faris、Yanagisawa Daijiro、Pahrudin Arrozi Aslina、Abu Bakar Zulzikry Hafiz、Taguchi Hiroyasu、Ishigaki Shinsuke、Morino Katsutaro、Tooyama Ikuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 694 Pages: 149392-149392
- DOI
  10.1016/j.bbrc.2023.149392
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07370, KAKENHI-PROJECT-23K28411
[Journal Article] アルツハイマー病の新規MRプローブ2023
- Author(s)
  遠山育夫、柳沢大治郎
- Journal Title
  
  医学のあゆみ
  
  Volume: 287 Pages: 985-990
- Data Source
  KAKENHI-PROJECT-23K28411
[Journal Article] Visualization of Amyloid Oligomers in the Brain of Patients with Alzheimer’s Disease2023
- Author(s)
  Tooyama Ikuo、Kato Tomoko、Taguchi Hiroyasu、Kageyama Yusuke、Irie Kazuhiro、Hirahara Yukie、Yanagisawa Daijiro
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 56 Issue: 6 Pages: 87-94
- DOI
  10.1267/ahc.23-00058
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2023-12-28
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14689, KAKENHI-PROJECT-22K07370, KAKENHI-PROJECT-23H00325, KAKENHI-PROJECT-23K28411
[Journal Article] Immunohistochemical Analysis of Mitochondrial Ferritin in the Midbrain of Patients with Parkinson’s Disease2023
- Author(s)
  Tsubaki Haruka、Yanagisawa Daijiro、Kageyama Yusuke、Hafiz Abu Baker Zulzikry、Mukaisho Ken-ichi、Tooyama Ikuo
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 56 Issue: 2 Pages: 21-27
- DOI
  10.1267/ahc.22-00109
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2023-04-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20588, KAKENHI-PROJECT-22K07370
[Journal Article] Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 382022
- Author(s)
  Chikugo Ayaka、Irie Yumi、Tsukano Chihiro、Uchino Ayumi、Maki Takahito、Kume Toshiaki、Kawase Taiji、Hirose Kenji、Kageyama Yusuke、Tooyama Ikuo、Irie Kazuhiro
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 13 Issue: 19 Pages: 2913-2923
- DOI
  10.1021/acschemneuro.2c00436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] LC3/FtMt Colocalization Patterns Reveal the Progression of FtMt Accumulation in Nigral Neurons of Patients with Progressive Supranuclear Palsy2022
- Author(s)
  Abu Bakar Zulzikry Hafiz、Bellier Jean-Pierre、Yanagisawa Daijiro、Kato Tomoko、Mukaisho Ken-ichi、Tooyama Ikuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 537-537
- DOI
  10.3390/ijms23010537
- NAID
  120007183408
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-22K07370, KAKENHI-PROJECT-20K20588
[Journal Article] A Histochemical Analysis of Neurofibrillary Tangles in Olfactory Epithelium, a Study Based on an Autopsy Case of Juvenile Alzheimer’s Disease2022
- Author(s)
  Shimizu S, Tojima I, Nakamura K, Kouzaki H, Kanesaka T, Ogawa N, Hashizume Y, Akatsu H, Hori A, Tooyama I, Shimizu T
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 55 Issue: 3 Pages: 93-98
- DOI
  10.1267/ahc.22-00048
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2022-06-29
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20588, KAKENHI-PROJECT-22H04923
[Journal Article] Structural analysis of the TxCo-1 antibody effective against the toxic conformer of amyloid β2022
- Author(s)
  Irie Kazuhiro、Irie Yumi、Matushima Yuka、Kita Akiko、Kageyama Yusuke、Tooyama Ikuo
- Journal Title
  
  Photon Factory Highlights 2021
  
  Volume: 2021 Pages: 30-31
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Structure Optimization of the Toxic Conformation Model of Amyloid β42 by Intramolecular Disulfide Bond Formation2022
- Author(s)
  Matsushima Yuka、Irie Yumi、Kageyama Yusuke、Bellier Jean‐Pierre、Tooyama Ikuo、Maki Takahito、Kume Toshiaki、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  ChemBioChem
  
  Volume: n/a Issue: 8
- DOI
  10.1002/cbic.202200029
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-19H00921
[Journal Article] Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models2022
- Author(s)
  Uchino Ayumi、Irie Yumi、Tsukano Chihiro、Kawase Taiji、Hirose Kenji、Kageyama Yusuke、Tooyama Ikuo、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 13 Issue: 16 Pages: 2517-2528
- DOI
  10.1021/acschemneuro.2c00363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-22KJ1961
[Journal Article] Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men2021
- Author(s)
  Syaifullah AH, Shiino A, Fujiyoshi A, Kadota A, Kondo K, Ito T, Segawa H, Moniruzzaman M, Waki T, Miyagawa N, Tooyama I, Ueshima H, Miura K; SESSA Research Group.
- Journal Title
  
  Alcohol
  
  Volume: 90 Pages: 57
- DOI
  10.1016/j.alcohol.2020.11.006
- URL
  https://pure.teikyo.jp/en/publications/f0bb33c9-2cc2-4461-9558-d588d907dde6
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04074, KAKENHI-PROJECT-18H03048, KAKENHI-PROJECT-19H03898
[Journal Article] Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain2021
- Author(s)
  Kageyama Yusuke、Irie Yumi、Matsushima Yuka、Segawa Tatsuya、Bellier Jean-Pierre、Hidaka Kumi、Sugiyama Hiroshi、Kaneda Daita、Hashizume Yoshio、Akatsu Hiroyasu、Miki Kunio、Kita Akiko、Walker Douglas G.、Irie Kazuhiro、Tooyama Ikuo
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 12 Issue: 18 Pages: 3418-3432
- DOI
  10.1021/acschemneuro.1c00416
- NAID
  120007161279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-16H06277
[Journal Article] Loss of lysosomal proteins Progranulin and Prosaposin associated with increased neurofibrillary tangle development in Alzheimer’s disease.2021
- Author(s)
  Mendsaikhan A, Tooyama I, Serrano GE, Beach TG, Walker DG
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 80 Issue: 8 Pages: 741-753
- DOI
  10.1093/jnen/nlab056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20588
[Journal Article] Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils2021
- Author(s)
  Yanagisawa D, Kato T, Taguchi H, Shirai N, Hirao K, Sogabe T, Tomiyama T, Gamo K, Hirahara Y, Kitada M, Tooyama I
- Journal Title
  
  Biomaterials
  
  Volume: 270 Pages: 120686-120686
- DOI
  10.1016/j.biomaterials.2021.120686
- NAID
  120006959909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06814, KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-19K20670, KAKENHI-PROJECT-17H03560
[Journal Article] Nasal extracts from patients with Alzheimer’s disease induce tau aggregates in a cellular model of tau propagation.2021
- Author(s)
  slina Pahrudin Arrozi, Daijiro Yanagisawa, Tomoko Kato, Hiroyasu Akatsu, Yoshio Hashizume, Daita Kaneda, Ikuo Tooyama
- Journal Title
  
  Journal of Alzheimer’s Disease Reports
  
  Volume: 5 Issue: 1 Pages: 263-274
- DOI
  10.3233/adr-210298
- NAID
  120007028250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20588, KAKENHI-PROJECT-19K20670
[Journal Article] Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease2021
- Author(s)
  Yanagisawa Daijiro、Ibrahim Nor Faeizah、Taguchi Hiroyasu、Morikawa Shigehiro、Tomiyama Takami、Tooyama Ikuo
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 5 Pages: 1362-1362
- DOI
  10.3390/molecules26051362
- NAID
  120007028249
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-17H03560
[Journal Article] Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study2021
- Author(s)
  Moniruzzaman Mohammad、Kadota Aya、Shiino Akihiko、Fujiyoshi Akira、Ito Takahiro、Haidar Syaifullah Ali、Miyagawa Naoko、Kondo Keiko、Hisamatsu Takashi、Segawa Hiroyoshi、Tooyama Ikuo、Ueshima Hirotsugu、Miura Katsuyuki、_ _
- Journal Title
  
  Journal of Physical Activity and Health
  
  Volume: 18 Issue: 2 Pages: 157-164
- DOI
  10.1123/jpah.2019-0659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03898, KAKENHI-PROJECT-18H04074
[Journal Article] Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases.2020
- Author(s)
  Tsubaki H, Tooyama I, Walker DG
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 24 Pages: 9357-9357
- DOI
  10.3390/ijms21249357
- NAID
  120006951355
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-19K07843
[Journal Article] Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells2020
- Author(s)
  Buyandelger Undral、Walker Douglas Gordon、Taguchi Hiroyasu、Yanagisawa Daijiro、Tooyama Ikuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 532 Issue: 4 Pages: 668-674
- DOI
  10.1016/j.bbrc.2020.08.114
- NAID
  120006887065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-19K07843
[Journal Article] Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis2020
- Author(s)
  Buyandelger Undral、Walker Douglas G.、Yanagisawa Daijiro、Morimura Toshifumi、Tooyama Ikuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 10 Pages: 3635-3635
- DOI
  10.3390/ijms21103635
- NAID
  120006862374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-19K07843
[Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020
- Author(s)
  Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: - Issue: 1 Pages: 45-60
- DOI
  10.3233/jad-191081
- NAID
  120006859791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-17K17812, KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-20K16491, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-18H02566
[Journal Article] Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.2019
- Author(s)
  Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Makpol S, Wan Ngah WZ, Damanhuri HA, Tooyama I
- Journal Title
  
  Alzheimers Dis.
  
  Volume: 72 Issue: 1 Pages: 229-246
- DOI
  10.3233/jad-181171
- NAID
  120006768262
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-17K01355
[Journal Article] Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology2019
- Author(s)
  Mendsaikhan Anarmaa、Tooyama Ikuo、Bellier Jean-Pierre、Serrano Geidy E.、Sue Lucia I.、Lue Lih-Fen、Beach Thomas G.、Walker Douglas G.
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 7 Issue: 1 Pages: 215-215
- DOI
  10.1186/s40478-019-0862-8
- NAID
  120006777342
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-19K07843, KAKENHI-PROJECT-17H03560
[Journal Article] Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat2018
- Author(s)
  Hamezah Hamizah Shahirah、Durani Lina Wati、Yanagisawa Daijiro、Ibrahim Nor Faeizah、Aizat Wan Mohd、Bellier Jean Pierre、Makpol Suzana、Ngah Wan Zurinah Wan、Damanhuri Hanafi Ahmad、Tooyama Ikuo
- Journal Title
  
  Experimental Gerontology
  
  Volume: 111 Pages: 53-64
- DOI
  10.1016/j.exger.2018.07.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-17H03560
[Journal Article] Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y52018
- Author(s)
  Yanagisawa Daijiro、Hamezah Hamizah Shahirah、Durani Lina Wati、Taguchi Hiroyasu、Tooyama Ikuo
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 12 Pages: e0208440-e0208440
- DOI
  10.1371/journal.pone.0208440
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-15K01282
[Journal Article] Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice2018
- Author(s)
  Durani Lina Wati、Hamezah Hamizah Shahirah、Ibrahim Nor Faeizah、Yanagisawa Daijiro、Nasaruddin Muhammad Luqman、Mori Masaki、Azizan Kamalrul Azlan、Damanhuri Hanafi Ahmad、Makpol Suzana、Wan Ngah Wan Zurinah、Tooyama Ikuo
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 64 Issue: 1 Pages: 249-267
- DOI
  10.3233/jad-170880
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560
[Journal Article] Tocotrienol-rich fraction modulates amyloid pathology and improves cognitive function in AβPP/PS1 mice.2017
- Author(s)
  Ibrahim NF, Yanagisawa D, Durania LW, Hamezaha HS, HDamanhuri HD, Wan Ngahb WZ, Tsuji M, Kiuchi Y, Ono K, Tooyama I
- Journal Title
  
  Journal of Alzheiemrs Disease
  
  Volume: 55 Issue: 2 Pages: 597-617
- DOI
  10.3233/jad-160685
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26461266, KAKENHI-PROJECT-15K16321
[Journal Article] Fluorine-19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice2017
- Author(s)
  Yanagisawa Daijiro、Ibrahim Nor Faeizah、Taguchi Hiroyasu、Morikawa Shigehiro、Kato Tomoko、Hirao Koichi、Shirai Nobuaki、Sogabe Takayuki、Tooyama Ikuo
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 96 Issue: 5 Pages: 841-851
- DOI
  10.1002/jnr.24188
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K01563, KAKENHI-PROJECT-26282145, KAKENHI-PROJECT-17H03560
[Journal Article] Fluorodopa is a promising fluorine-19 MRI probe for evaluating striatal dopaminergic function in a rat model of Parkinson’s disease.2017
- Author(s)
  Yanagisawa D, Oda K, Inden M, Morikawa S, Inubushi T, Taniguchi T, Hijioka M, Kitamura Y, Tooyama I
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 印刷中 Issue: 7 Pages: 1485-1494
- DOI
  10.1002/jnr.23983
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-15K16321
[Journal Article] Mitochondrial Ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates alpha-Synuclein expression.2017
- Author(s)
  Hongpeng Guan, HongKuan Yang, Mingchun Yang, Daijiro Yanagisawa, Jean-Pierre Bellier, Masaki Mori, Shogo Takahata, Takashi Nonaka, Shiguang Zhao, Ikuo Tooyama.
- Journal Title
  
  Experimental Neurology
  
  Volume: 291 Pages: 51-61
- DOI
  10.1016/j.expneurol.2017.02.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01486, KAKENHI-PROJECT-15K15387, KAKENHI-PROJECT-15K08327
[Journal Article] Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM.2017
- Author(s)
  Shiino A, Chen Y-W, Tanigaki K, Yamada A, Vigers P, Watanabe T, Tooyama I, Akiguchi I
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Pages: 39818-39818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum2017
- Author(s)
  Durani Lina Wati、Hamezah Hamizah Shahirah、Ibrahim Nor Faeizah、Yanagisawa Daijiro、Makpol Suzana、Damanhuri Hanafi Ahmad、Tooyama Ikuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 493 Issue: 3 Pages: 1356-1363
- DOI
  10.1016/j.bbrc.2017.09.164
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560
[Journal Article] Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions2017
- Author(s)
  Hamezah Hamizah Shahirah、Durani Lina Wati、Ibrahim Nor Faeizah、Yanagisawa Daijiro、Kato Tomoko、Shiino Akihiko、Tanaka Sachiko、Damanhuri Hanafi Ahmad、Ngah Wan Zurinah Wan、Tooyama Ikuo
- Journal Title
  
  Experimental Gerontology
  
  Volume: 99 Pages: 69-79
- DOI
  10.1016/j.exger.2017.09.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560
[Journal Article] Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis.2016
- Author(s)
  Yang M, Yang H, Guan H, Bellier JP, Zhao S, Tooyama I
- Journal Title
  
  Neuroscience
  
  Volume: 328 Pages: 92-106
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Amyloid imaging using fluorine-19 magnetic resonance imaging (19F-MRI).2016
- Author(s)
  Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S
- Journal Title
  
  Ageing Research Reviews
  
  Volume: 15 Pages: 1568-1637
- DOI
  10.1016/j.arr.2015.12.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K01282, KAKENHI-PROJECT-15K16321, KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-24240071, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26282145
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid ß aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochem Biophys Report
  
  Volume: 4 Pages: 357-368
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] Up-regulation of mitochondrial ferritin by proinflammatory cytokines: Implications for a role in Alzheimer’s disease.2015
- Author(s)
  Yang H, Guan H, Yang M, Liu Z, Takeuchi S, Yanagisawa D, Vincent SR, Zhao S, Tooyama I
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 45 Issue: 3 Pages: 797-811
- DOI
  10.3233/jad-142595
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid β aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochem Biophys Report
  
  Volume: 4 Pages: 357-368
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.2015
- Author(s)
  Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I
- Journal Title
  
  Neurosci Lett.
  
  Volume: ５９０１ Pages: 19-24
- DOI
  10.1016/j.neulet.2015.02.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-26290022, KAKENHI-PUBLICLY-26111709
[Journal Article] Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds.2015
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Australian Journal of Chemistry
  
  Volume: 68 Pages: 224-229
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Diagnosis of amyloid-positive mild cognitive impairment using structural magnetic resonance imaging: the worth of multiple regions of interest.2015
- Author(s)
  Vigers P, Shiino A, Tooyama I
- Journal Title
  
  Integrative Molecular Medicine
  
  Volume: 2 Pages: 205-213
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid β aggregation2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 4 Pages: 357-368
- DOI
  10.1016/j.bbrep.2015.10.009
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16321, KAKENHI-PROJECT-26670554
[Journal Article] Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds.2015
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Australian Journal of Chemistry
  
  Volume: 68 Pages: 224-229
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid ß aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochem Biophys Report
  
  Volume: 4 Pages: 357-368
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K01282
[Journal Article] ynthesis and Tautomerism of Curcumin Derivatives and Related Compounds.2015
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Australian Journal of Chemistry
  
  Volume: 68 Pages: 224-229
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] フッ素ＭＲ画像法によるアミロイドオリゴマーのin vivo病態解析2014
- Author(s)
  遠山育夫、柳沢大治郎、NOr Faeizah Ibrahim, 田口弘康
- Journal Title
  
  遺伝子医学MooK
  
  Volume: 26 Pages: 190-194
- Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] Inhalable Curcumin: Offering the Potential for Translation to Imaging and Treatment of Alzheimer's Disease.2014
- Author(s)
  McClure R, Yanagisawa D, Stec D, Koktysh D, Xhillari D, Jaeger R, Chekmenev E, Tooyama I, Gore1 JC, Pham W
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 144 Issue: 1 Pages: 283-295
- DOI
  10.3233/jad-140798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554
[Journal Article] Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds2014
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Australian Journal of Chemistry
  
  Volume: 68 Issue: 2 Pages: 224-229
- DOI
  10.1071/ch14464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-25750159, KAKENHI-PROJECT-26670554, KAKENHI-PROJECT-26282145
[Journal Article] Development of a method to measure Aβ42 in nasal cavity samples and its appilication in normal human volunteers.2014
- Author(s)
  Nanjo T, Fukuhara T, Kameshima N, Yanagisawa D, Shimizu S, Shimizu T, Shiino A, Akatsu H, Yamamotyo T, Tooyama I
- Journal Title
  
  Journal of Brain Science
  
  Volume: 4 Pages: 5-23
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26640042
[Journal Article] Curcumin derivative with substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PSI mice2014
- Author(s)
  Yanagisawa D, Ibraham NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I
- Journal Title
  
  Neurobiol Aging
  
  Volume: 36 Issue: 1 Pages: 210-210
- DOI
  10.1016/j.neurobiolaging.2014.07.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-25750159, KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554, KAKENHI-PROJECT-26282145
[Journal Article] A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.2014
- Author(s)
  Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K.
- Journal Title
  
  Am J Hum Genet.
  
  Volume: 95 Issue: 3 Pages: 294-300
- DOI
  10.1016/j.ajhg.2014.07.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590400, KAKENHI-PROJECT-24592441, KAKENHI-PUBLICLY-25129701, KAKENHI-PROJECT-25293041, KAKENHI-PROJECT-25460403, KAKENHI-PROJECT-25461537, KAKENHI-PROJECT-25670087, KAKENHI-PROJECT-25860842, KAKENHI-PROJECT-25870074, KAKENHI-PROJECT-26870067
[Journal Article] Preferred features of a fluorine-19 MRI probe foramyloid detection in the brain2014
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Sogabe T, Toovama I
- Journal Title
  
  J AIzhei mer's Dis
  
  Volume: 39 Issue: 3 Pages: 617-631
- DOI
  10.3233/jad-131025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-23300188, KAKENHI-PUBLICLY-24111522, KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-24240071, KAKENHI-PROJECT-25750159
[Journal Article] Knockdown of p53 suppresses Nanog expression in embryonic stem cells.2013
- Author(s)
  Abdelalim EM, Tooyama I.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 443 Issue: 2 Pages: 652-657
- DOI
  10.1016/j.bbrc.2013.12.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590400
[Journal Article] β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway.2013
- Author(s)
  Kameshima, N., Yanagisawa, D., Tooyama, I.
- Journal Title
  
  Neurosci. Res
  
  Volume: 76 Issue: 3 Pages: 169-172
- DOI
  10.1016/j.neures.2013.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111522
[Journal Article] Visualizing Hepatic Copper Release in Long-Evans Cinnamon Rats Using Single-Photon Emission Computed Tomography.2013
- Author(s)
  Yezdimer, E.M., Umemoto, T., Yamada, H., Makino, S., Tooyama I
- Journal Title
  
  Appl. Biochem. Biotechnol
  
  Volume: 170 Issue: 5 Pages: 1138-1150
- DOI
  10.1007/s12010-013-0252-9
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111522, KAKENHI-PROJECT-24590400
[Journal Article] Mitochondrial ferritin in neurodegenerative diseases.2013
- Author(s)
  Yang, H., Yang, M., Guan, H., Liu, Z., Zhao, S., Takeuchi, S., Yanagisawa, D., Tooyama. I.
- Journal Title
  
  Neurosci Res.
  
  Volume: 77 Issue: 1-2 Pages: 1-7
- DOI
  10.1016/j.neures.2013.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111522, KAKENHI-PROJECT-24590400
[Journal Article] Generation of a Monoclonal Antibody Specifically Reacting with Neuron-specific TATA-Box Binding Protein-Associated Factor 1 (N-TAF1)2013
- Author(s)
  Makino S, Masuda C, Ando S, Tamiya G, Tooyama I.
- Journal Title
  
  Antibodies
  
  Volume: 2 Issue: 1 Pages: 1-8
- DOI
  10.3390/antib2010001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590300, KAKENHI-PROJECT-24590400, KAKENHI-PUBLICLY-24112702
[Journal Article] Distinct Localization of Peripheral and Central Types of Choline Acetyltransferase in the Rat Cochlea2013
- Author(s)
  Kitanishi T, Aimi Y, Kitano H, Suzuki M, Kimura H, Saito A, Shimizu T, Tooyama I
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 46 Issue: 5 Pages: 145-152
- DOI
  10.1267/ahc.13021
- NAID
  130003381868
- ISSN
  0044-5991, 1347-5800
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease2012
- Author(s)
  亀島直子
- Journal Title
  
  Neuroscience Letters
  
  Volume: 513 Issue: 2 Pages: 166-169
- DOI
  10.1016/j.neulet.2012.02.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07718, KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-23650192
[Journal Article] Correlation of A β deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease2012
- Author(s)
  Kameshima N, Nanjou T, Fukuhara T, Yanagisawa D, Tooyama I
- Journal Title
  
  Neurosci Lett
  
  Volume: 513 Pages: 166-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650192
[Journal Article] UBR5 Gene Mutation Is Associated with Familial Adult Myoclonic Epilepsy in a Japanese Family2012
- Author(s)
  Kato T, Tamiya G, Koyama S, Nakamura T, Makino S, Arawaka S, Kawanami T, Tooyama I.
- Journal Title
  
  ISRN Neurol
  
  Volume: 2012 Pages: 508308-508308
- DOI
  10.5402/2012/508308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590300, KAKENHI-PROJECT-24590400, KAKENHI-PUBLICLY-24112702
[Journal Article] In Vivo Detection of Copper Ions by Magnetic Resonance ImagingUsing a Prion-Based Contrast Agent.2012
- Author(s)
  Makino S
- Journal Title
  
  Appl Biochem Biotechnol.
  
  Volume: 168 Issue: 3 Pages: 504-518
- DOI
  10.1007/s12010-012-9792-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-24590400
[Journal Article] アルツハイマー病診断のための新規MR造影剤の開発2012
- Author(s)
  遠山育夫
- Journal Title
  
  神戸医師会報
  
  Volume: 2月号 Pages: 51-57
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] In vivo detection of amyloid b deposition using 19F magnetic resonance imaging with a 19F-containing curcumin derivative in a mouse model of Alzheimer’s disease.2011
- Author(s)
  柳沢大治郎、遠山育夫ほか
- Journal Title
  
  Neuroscience
  
  Volume: 184 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650192
[Journal Article] 核磁気共鳴画像によるアミロイドイメージング用トレーサー2011
- Author(s)
  遠山育夫, 田口弘康、柳沢大治郎
- Journal Title
  
  鳥取医療
  
  Volume: 4 Pages: 68-74
- NAID
  40019763907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] In vivo detection of amyloid β deposition using 19F magnetic resonance imaging with a 19F-containing curcumin derivative in a mouse model of Alzheimer's disease2011
- Author(s)
  Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitania M, Shirai N, Hirao K, Shiino A, Inubushid T, Tooyama I
- Journal Title
  
  Neuroscience
  
  Volume: 184 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650192
[Journal Article] Curcuminoid binds to amyloid β(1-42) oligomer and fibril.2011
- Author(s)
  Yanagisawa H, Taguchi H, Yamamoto A, Shirai N, Hirao K, Tooyama I
- Journal Title
  
  J Alzheimers Dis
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex2011
- Author(s)
  Wang L, Yang H, Zhao S, Sato H, Konishi Y, Beach TG, Abdelalim EM, Bisem NJ, Tooyama I
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina2010
- Author(s)
  Abdelalim EM, Tooyama I
- Journal Title
  
  Peptides 31
  
  Pages: 180-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Relationship between the tautomeric structures of curcumin derivatives and their A β-binding activities in the context of therapies for Alzheimer's disease.2010
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada K N, Yamamoto A, Tooyama I
- Journal Title
  
  Biomaterials
  
  Volume: 31 Pages: 4179-4185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] Amyloid imaging using high-filed magnetic resonance.2010
- Author(s)
  Amatsubo T, Yanagisawa D, Morikawa S, Tooyama I
- Journal Title
  
  Magn Reson Med Sci
  
  Volume: 9 Pages: 95-99
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder2009
- Author(s)
  Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
- Journal Title
  
  Am J Med Genet B Neuropsychiatr Genet. 150B(7)
  
  Pages: 967-976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] 動物モデルを使った高磁場MRIによる認知症診断の可能性2009
- Author(s)
  遠山育夫, 田口弘康, 雨坪知音, 森川茂廣
- Journal Title
  
  Cognition and Dementia 8
  
  Pages: 53-57
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19) F magnetic resonance imaging.2009
- Author(s)
  Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I.
- Journal Title
  
  Neurosci Res. 63
  
  Pages: 76-81
- NAID
  10027499428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging2009
- Author(s)
  Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I.
- Journal Title
  
  Neurosci Res 63
  
  Pages: 76-81
- NAID
  10027499428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging.2009
- Author(s)
  Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I.
- Journal Title
  
  Neurosci Res 63
  
  Pages: 76-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury.2009
- Author(s)
  Yanagida T, Tsushima J, KitamuraY, Yanagisawa D, Takata T, Shibaike T, Yamamoto A, Taniguchi T, Yasui H, Taira T, Morikawa S, Inubhi T Tooyama I, Ariga H
- Journal Title
  
  Oxidative Medicine and Cellular Longevity 2
  
  Pages: 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using 19F magnetic resonance imaging2009
- Author(s)
  Amatsubo T, Morikawa S, Matsuda K, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I
- Journal Title
  
  Neurosci Res 63
  
  Pages: 76-81
- NAID
  10027499428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Application of microglia to possible cell therapy for Alzheimer's disease2009
- Author(s)
  Ikuo Tooyama, Hiroaki Nakahara, Song Yang
- Journal Title
  
  鳥取臨床医学 2
  
  Pages: 142-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury.2009
- Author(s)
  Yanagida T, Tsushima J, Kitamura Y, Yanagisawa D, Takata T, Shibaike T, Yamamoto A, Taniguchi T, Yasui H, Morikawa S, Inubiushi T, Tooyama I, Agira H
- Journal Title
  
  Oxid Med Cell Longev. 2
  
  Pages: 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2(PCNT2) in bipolar disorder2008
- Author(s)
  Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Tohyama M, Yoshikawa T, Mori N.
- Journal Title
  
  Biol Psychiatry 63(7)
  
  Pages: 678-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] 高次機能心の障害を科学する2008
- Author(s)
  遠山正彌, 森則夫
- Journal Title
  
  脳21 11(1)
  
  Pages: 65-71
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats.2008
- Author(s)
  Yanagisawa D, Kitamura Y, Inden M, Takata K, Taniguchi T, Morikawa S, Morita M, Inubushi T, Tooyama L, Taira T, Iguchi-Ariga SM, Akaike A, Ariga H
- Journal Title
  
  J Cereb Blood Flow Metab 28
  
  Pages: 563-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Fluorine-19 Fast Recovery Fast Spin Echo Imaging for Mapping of 5-Fluorouracil2008
- Author(s)
  Morikawa S, Inubushi T, Morita M, Murakami K, Masuda C, Maki J, Tooyama I
- Journal Title
  
  Magn Resn Med Sci 6
  
  Pages: 235-240
- NAID
  10020158662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization2008
- Author(s)
  Kubota K, Kumamoto N, Matsuzaki S. Hashimoto R, Hattori T, Okuda H, Takam H, Taked M, Katayama T, Tohyama M.
- Journal Title
  
  Biochem Biophys Res Commun 379
  
  Pages: 191-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons.2008
- Author(s)
  Abdelalim EM, (4名省略) Mori N, Tooyama I.
- Journal Title
  
  Neuroscience 155(1)
  
  Pages: 192-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] 【21世紀の脳科学をみすえて】高次機能心の障害を科学する2008
- Author(s)
  遠山正彌, 森則夫
- Journal Title
  
  脳21 11巻1号
  
  Pages: 65-71
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Microglial transplantation increases amyloid-β clearance in Alzheimer model rats.2007
- Author(s)
  Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M Inubushi T, Tsuichiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I
- Journal Title
  
  FEBS Letters 581
  
  Pages: 475-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659110
[Journal Article] Immunohistochemical mapping of NPR-A in the brainstem of Macaca Fascicularis.2007
- Author(s)
  Abdelalim EM, Osman, AHK, Takada T, Torii R, Tooyama I
- Journal Title
  
  Neuroscience 145
  
  Pages: 1087-1096
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Immunohistochemical mapping of natriuretic peptide receptor-A in the brainstem of Macaca fascicularis.2007
- Author(s)
  Abdelalim EM, Osman AH, Takada T, Torii, Tooyama I
- Journal Title
  
  Neuroscience 145
  
  Pages: 1087-1096
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.2007
- Author(s)
  Kimura S, Bellier J-P, Matsuo A, Tooyama I, Kimura H
- Journal Title
  
  Neurochem Internatinal 50
  
  Pages: 251-255
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Magnetic resonance imaging using hemagglutinating virus of Japan-envelope vector successfully detects localization of intra-cardially administered microglia in normal mouse brain2007
- Author(s)
  Song Y, Morikawa S, Morita M, Inubushi T, Takada T, Torii R, Tooyama I.
- Journal Title
  
  Neurosci Lett. 395(1)
  
  Pages: 42-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] ミクログリア研究の新しい展開アルツハイマー病の細胞治療法の可能性.2007
- Author(s)
  遠山育夫.
- Journal Title
  
  Dementia Japan 21(3)
  
  Pages: 261-269
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Fluorine-19 fast recovery fast spin echo imaging for mapping 5-fluorouracil2007
- Author(s)
  Morikawa S, Inubushi T, Morita M, Murakami K, Masuda C, Maki J, Tooyama I.
- Journal Title
  
  Magnetic Resonance Medical Science 6(4)
  
  Pages: 235-40
- NAID
  10020158662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Fluorine-19 fast recovery fast spin echo imaging for mapping 5-fluorouracil2007
- Author(s)
  Morikawa S, Inubushi T, Morita M, Murakami K, Masuda C, Maki J, Tooyama I.
- Journal Title
  
  Magn Reson Med Sci. 6(4)
  
  Pages: 235-40
- NAID
  10020158662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] The MR tracking of ATDC5 cells using fluorinated poly-L-Lysine-CF3.2007
- Author(s)
  Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I.
- Journal Title
  
  Biomaterials 28
  
  Pages: 434-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats2007
- Author(s)
  Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M, Inubushi T, Tsuchiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I
- Journal Title
  
  FEBS Lett. 581(3)
  
  Pages: 475-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.2007
- Author(s)
  Kimura S, Bellier J-P, Matsuo A, Tooyama I, Kimura H
- Journal Title
  
  Neurochemical International 581
  
  Pages: 251-255
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Molecular Cloning of BNP from heart and its immunohistochemical localization in the hypothalamus of monkey2006
- Author(s)
  EM Abdelalim, T Takada, Ryuzo Torii, I Tooyama
- Journal Title
  
  Peptides 27
  
  Pages: 1886-1893
- Data Source
  KAKENHI-PROJECT-18659110
[Journal Article] In vitro expression of natriuretic peptides in cardiomyocytes differentiated from monkey embryonic stem cells.2006
- Author(s)
  Abdelalim EM, Takada T, Toyoda F, Omatsu-Kanbe M, Matsuura H, Tooyama I, R Torii.
- Journal Title
  
  Biochem Biophys Res Commun 340
  
  Pages: 689-695
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Localization of fibroblast growth factor-1 (FGF1) in cholinergic neurons innervating the rat larynx.2006
- Author(s)
  Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I
- Journal Title
  
  J Histochem Cytochem 54
  
  Pages: 1061-1067
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Localization of fibroblast growth factor-1 (FGF1) in cholinergic neurons innervating the rat larynx.2006
- Author(s)
  Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I
- Journal Title
  
  Journal of Histochemistry and Cytochemistry 54
  
  Pages: 1061-1067
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Localization of fibroblast growth factor-1(FGF1) in cholinergic neurons innervating the rat larynx.2006
- Author(s)
  Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I
- Journal Title
  
  J Histochem Cytochem 54
  
  Pages: 1061-1067
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Molecular Cloning of BNP from Heart and Its Immunohistochemical Localization in the Hypothalamus of Monkey.2006
- Author(s)
  Abdelalim EM, Takada T, Torii R, Tooyama I
- Journal Title
  
  Peptides 27
  
  Pages: 1886-1893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain2006
- Author(s)
  Song Y, Morikawa S, Inubushi T, Takada T, Torii R, Kitamura Y, Taniguchi T, Tooyama I.
- Journal Title
  
  Histol Histopathol 21
  
  Pages: 705-711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] In Vitro Expression of Natriuretic Peptides in Cardiomyocytes Differentiated from Monkey Embryonic Stem Cells2006
- Author(s)
  EM Abdelalim, T Takada, F Toyoda, M Omatsu, H Matsuura, I Tooyama, Ryuzo Torii
- Journal Title
  
  Biochemical Biophysical Research Communications 340
  
  Pages: 689-695
- Data Source
  KAKENHI-PROJECT-18659110
[Journal Article] Molecular Cloning of BNP from Heart and Its Immunohistochemical Localization in the Hypothalamus of Monkey.2006
- Author(s)
  Abdelalim EM, Takada T, Torii R, Tooyama I
- Journal Title
  
  Peptides 29
  
  Pages: 1886-1893
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Comparison of FGF1 (aFGF) Expression between the Dorsal Motor Nucleus of Vagus and the Hypoglossal Nucleus of Rat2006
- Author(s)
  Toyoda K, Okano H, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Tooyama I
- Journal Title
  
  Acta Histochem Cytochem 39
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Comparison of FGF1(aFGF) Expression between the Dorsal Motor Nucleus of Vagus and the Hypoglossal Nucleus of Rat.2006
- Author(s)
  Toyoda K, Okano H, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Tooyama I
- Journal Title
  
  Acta Histochem Cytochem 39
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] In vitro expression of natriuretic peptides in cardiomyocytes differentiated from monkey embryonic stem cells.2005
- Author(s)
  Abdelalim EM, Takada T, Toyoda F, Omatsu-Kanbe M, Matsuura H, Tooyama I, Torii R
- Journal Title
  
  Biochem Biophys Res Commun 340
  
  Pages: 689-695
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat cholineacetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.2005
- Author(s)
  A Matsuo, JP Belier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochemistry International 46・5
  
  Pages: 423-433
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in untracellular translocation.2005
- Author(s)
  A Matsuo, JP Bellier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochemical International 46
  
  Pages: 423-433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in untracellular translocation.2005
- Author(s)
  A Matsuo, JP Bellier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochem International 46
  
  Pages: 423-433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Immunohistochemical study of TAFII250 in the rat laryngeal nervous system.2005
- Author(s)
  Okano H, Bamba H, Hisa Y, Makino S, Ando S, Tammiya G, Goto S, Kaji R, Tooyama I
- Journal Title
  
  Histochem Histopathol 20
  
  Pages: 1049-1035
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Immunohistochemical study of TAFII250 in the rat laryngeal nervous system2005
- Author(s)
  Okano H, Bamba H, Hisa Y, Makino S, Ando S, Tammiya G, Goto S, Kaji R, Tooyama I
- Journal Title
  
  Histol Histopathol 20
  
  Pages: 1029-1035
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Immunohistochemical study of TAFII250 in the rat laryngeal nervous system.2005
- Author(s)
  Okano H, Bamba H, Hisa Y, Makino S, Ando S, Tammiya G, Goto S, Kaji R, Tooyama I
- Journal Title
  
  Histology and Histopathology 20
  
  Pages: 1049-1035
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Cloning and structure of monkey cChAT from the striatum of Japanese macaque (Macaca fuscata)2005
- Author(s)
  Song Y, Kimura S, Bellier JP, Yasuhara O, Kimura H, Torii, R, Tooyama I
- Journal Title
  
  Neuroscience Research 52(Supple)
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Coexpression pattern of two variants of choline acetyltransferase and neuronal nitric oxide synthase in myenteric neurons of porcine ileum.2004
- Author(s)
  A Brehmer, F Schrodl, W Neuuber, I Tooyama, H Kimura
- Journal Title
  
  Journal of Chemical Neuroanatomy 27
  
  Pages: 33-41
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Coexpression pattern of two variants of choline acetyltransferase and neuronal nitric oxide synthase in myenteric neurons of porcine ileum.2004
- Author(s)
  A Brehmer, F Schrodl, W Neuuber, I Tooyama, H Kimura
- Journal Title
  
  J Chem Neuroanat 27
  
  Pages: 33-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Coexpression pattern of two variants of choline acetyltransferase and neuronal nitric oxide synthase in myenteric neurons of porcine ileum.2004
- Author(s)
  A Brehmer, F Schrodl, W Neuuber, I Tooyama, H Kimura
- Journal Title
  
  Journal Chemical Neuroanatomy 27
  
  Pages: 33-41
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Effective magnetic labeling of transplanted cells with HVJ-E for magnetic resonance imaging.2004
- Author(s)
  Toyoda K, Tooyama I, et al.
- Journal Title
  
  Neuroreport 15・4
  
  Pages: 589-593
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltranferase.2004
- Author(s)
  O Yasuhara, Y Aimi, A Shibano, A Matsuo, JP Bellier, M Park, I Tooyama, H Kimura
- Journal Title
  
  J Comp Neurol 472
  
  Pages: 232-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Ameliorative effects of acetyl-L-carnitine and acidic fibroblast growth factor fragment analog on brain lipid hydroperoxide level, passive avoidance learning and/or immunoreactivity for choline acetyltransferase in the medial septum in senescenceaccelerated mice.2004
- Author(s)
  K Sasaki, M Ishibashi, F Yasui, S Matsugo, I Tooyama, H Kimura, O Oomura
- Journal Title
  
  International Congress Series 1260
  
  Pages: 123-128
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.2004
- Author(s)
  A Casini, A Pinna, I Tooyama, H Kimura, G Di Chiara, TG Renda
- Journal Title
  
  European Journal of HIstochemistry 48
  
  Pages: 135-140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.2004
- Author(s)
  A Casini, A Pinna, I Tooyama, H Kimura, G Di Chiara, TG Renda
- Journal Title
  
  Eur J Histochem 48
  
  Pages: 135-140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltranferase.2004
- Author(s)
  O Yasuhara, Y Aimi, A Shibano, A Matsuo, JP Bellier, M Park, I Tooyama, H Kimura
- Journal Title
  
  Journal Comparative Neurology 472
  
  Pages: 232-245
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Amyloid Imaging Using High-Field Magnetic Resonance
- Author(s)
  Amatsubo T, Morikawa S, Taguchi H, Tooyama I
- Journal Title
  
  Magn Resn Med Sci (in press)
- NAID
  10027851175
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Amyloid Imaging Using High-Field Magnetic Resonance
- Author(s)
  Tomone Amatsubo, Shigehiro Morikawa, Hiroyasu Taguchi, Ikuo Tooyama
- Journal Title
  
  Magn Resn Med Sci (in press)
- NAID
  10027851175
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] 動物モデルを使った高磁場MRIによる認知症診断の可能性.
- Author(s)
  遠山育夫, 田口弘康, 雨坪知音, 森川茂廣
- Journal Title
  
  Cognition and Dementia 8(2)
  
  Pages: 121-125
- Data Source
  KAKENHI-PROJECT-19209039
[Patent] 配座固定アミロイドβ４２誘導体2024
- Inventor(s)
  入江一浩、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Holder
  入江一浩、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-010920
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23H00325
[Patent] 抗アミロイドβ４２モノクローナル抗体2021
- Inventor(s)
  入江一浩、松島由佳、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Holder
  入江一浩、松島由佳、入江由美、遠山育夫、景山裕介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-059059
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H00921
[Patent] ミトコンドリアフェリチン発現誘導剤2020
- Inventor(s)
  遠山育夫、柳沢大治郎、田口弘康
- Industrial Property Rights Holder
  遠山育夫、柳沢大治郎、田口弘康
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-144256
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-17H03560
[Patent] チオレドキシン相互作用タンパク質発現抑制剤2020
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-141272
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-17H03560
[Patent] アミロイドオリゴマーの画像診断薬2019
- Inventor(s)
  遠山育夫、田口弘康、柳沢大次郎、加藤智子
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-033405
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H03560
[Patent] 神経難病の画像診断薬及び体外診断薬2017
- Inventor(s)
  田口弘康、遠山育夫, 柳沢大治郎、曾我部孝行、白井伸明、平尾浩一
- Industrial Property Rights Holder
  田口弘康、遠山育夫, 柳沢大治郎、曾我部孝行、白井伸明、平尾浩一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-046350
- Filing Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-15K01282
[Patent] 神経難病の画像診断薬及び体外診断薬2017
- Inventor(s)
  遠山育夫, 田口弘康、柳沢大治郎、曾我部孝行、白井伸明、平尾浩一
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-046350
- Filing Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-26290022
[Patent] 神経難病のMR画像診断薬2014
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Filing Date
  2014-01-06
- Overseas
- Data Source
  KAKENHI-PUBLICLY-24111522
[Patent] 採取パーツと採取パーツを備える生体組織採取具2014
- Inventor(s)
  南條俊文、福原崇臣、濱中健一、遠山育夫、清水志乃
- Industrial Property Rights Holder
  パナソニックヘルスケア株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-011126
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462663
[Patent] 生体組織採取器具2014
- Inventor(s)
  森分優太、篠原紀行、南條俊文、濱中健一、遠山育夫、清水志乃等
- Industrial Property Rights Holder
  パナソニックヘルスケア株式会社
- Industrial Property Rights Type
  意匠
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462663
[Patent] 神経難病のMR画像診断薬2014
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Filing Date
  2014-01-06
- Overseas
- Data Source
  KAKENHI-PROJECT-22300153
[Patent] 神経難病のＭＲ画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-202531
- Filing Date
  2013-09-27
- Data Source
  KAKENHI-PUBLICLY-24111522
[Patent] 神経難病のMR画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-202531
- Filing Date
  2013-09-27
- Data Source
  KAKENHI-PROJECT-22300153
[Patent] 神経難病のMR画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-001948
- Filing Date
  2013-01-09
- Data Source
  KAKENHI-PROJECT-22300153
[Patent] 神経難病のＭＲ画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-202531
- Filing Date
  2013-09-27
- Data Source
  KAKENHI-PROJECT-22300153
[Patent] 神経難病のＭＲ画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-001948
- Filing Date
  2013-01-09
- Data Source
  KAKENHI-PUBLICLY-24111522
[Patent] アミロイドβ蛋白凝集体結合化合物とその用途2012
- Inventor(s)
  田口弘康、遠山育夫、柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Number
  2012-099685
- Filing Date
  2012-04-25
- Data Source
  KAKENHI-PROJECT-23650192
[Patent] 認知症の治療及び予防用の医薬組成物2012
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-260046
- Filing Date
  2012-11-18
- Data Source
  KAKENHI-PUBLICLY-24111522
[Patent] 球状金ナノ粒子組成物2007
- Inventor(s)
  細見智栄、遠山育夫、犬伏俊郎、森川茂廣、山田弘志
- Industrial Property Rights Holder
  国立大学法人滋賀医科大学、株式会社アイ、エス、ティ
- Industrial Property Number
  2007-338733
- Filing Date
  2007-12-28
- Data Source
  KAKENHI-PROJECT-16100006
[Presentation] 神経難病におけるニューロセラノスティクス2024
- Author(s)
  遠山育夫
- Organizer
  第２回京都薬科大学シナジー共同研究講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K28411
[Presentation] 毒性アミロイドβの立体構造に立脚した抗体開発2023
- Author(s)
  景山裕介、入江由美、松島由佳、瀬川辰也、喜田昭子、赤津祐康、金田大太、橋詰良夫、入江一浩、遠山育夫
- Organizer
  第12回日本認知症予防学会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00325
[Presentation] アミロイドβ40の平行β-シート型3量体モデルの構造最適化2023
- Author(s)
  内野歩美、入江由美、筑後文馨、塚野千尋、牧俊人、久米利明、景山裕介、遠山育夫、入江一浩
- Organizer
  2023年度日本農芸化学会大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 鼻粘膜に存在する認知症原因タンパクのプリオン活性を利用した診断法の検討2023
- Author(s)
  遠山育夫、Aslina Pahrudin Arrozi、柳沢大治郎、水上民夫、金田大太
- Organizer
  第50回日本脳科学会
- Data Source
  KAKENHI-PROJECT-20K20588
[Presentation] アミロイドβ40の毒性２および３量体モデルの構造最適化2023
- Author(s)
  入江一浩、内野歩美、筑後文馨、入江由美、塚野千尋、川瀬泰司、廣瀬賢治、景山裕介、遠山育夫、柳田亮、牧俊人、久米利明
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-23H00325
[Presentation] Development of a conformation specific antibody identifying toxic conformation of amyloid β peptide2022
- Author(s)
  Kageyama Yusuke、Irie Yumi、Matsushima Yuka、Segawa Tatsuya、Kaneda Daita、Hashizume Yoshio、Akatsu Hiroyasu、Miki Kunio、Kita Akiko、Irie Kazuhiro、Tooyama Ikuo
- Organizer
  第63回日本神経病理学会総会学術研究会（京都）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] MRIを用いた認知症の分子イメージング2020
- Author(s)
  遠山育夫、柳沢大治郎、田口弘康
- Organizer
  第39回日本認知症学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Therapeutic effects of a curcumin derivative Shiga-Y5 in the brain of a mouse model of Alzheimer’s disease2019
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第13回日中合同組織細胞化学セミナー
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] :Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of APP/PS1 transgenic mice and its modulation by tocotrienol-rich fraction.2019
- Author(s)
  Hamezah HS, Yanagisawa D, Durani LW, Ibrahim NF, Damanhuri HA, Ngah WZW, Tooyama
- Organizer
  第46回日本脳科学会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] rTg4510マウスのタウ蓄積量を変動させる因子の探索2019
- Author(s)
  柳沢　大治郎、Hamizah Shahirah Hamezah、Aslina Pahrudin Arrozi、遠山　育夫
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Effect of genetic background on tau accumulation in rTg4510 mice2019
- Author(s)
  Daijiro Yanagisawa, Hamizah Shahirah Hamezah, Aslina Pahrudin Arrozi, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] ヒト組織切片を用いたアルツハイマー病の神経原線維変化に結合する新規化合物の探索2019
- Author(s)
  加藤智子，柳沢大治郎，田口弘康，遠山育夫
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Fluorine-19 magnetic resonance imaging to detect tau pathology in rTg4510 mice2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第18回国際薬理学・臨床薬理学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Effect of TRF on memory, proteome profile, and amyloid pathology in APP/PS1 mice2018
- Author(s)
  Hamizah Shahirah Hamezah, Lina Wati Durani, Nor Faeizah Ibrahim, Daijiro Yanagisawa, Suzana Makpol, Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Ikuo Tooyama
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] etection of abnormal protein accumulation in Alzheimer’s disease using magnetic resonance imaging2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第５回モンゴル神経科学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Detection of abnormal protein accumulation in Alzheimer’s disease using magnetic resonance imaging.2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  The 5th Annual Meeting of Mongolian Neuroscience Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] F-methyl-curcumin-1 (Shiga-Y5) はアルツハイマー病の画像診断や治療の候補化合物である2018
- Author(s)
  遠山育夫、柳沢大治郎、田口弘康
- Organizer
  第45回日本脳科学会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MRIによる脳内タウ凝集体の検出2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Shigehiro Morikawa, Tomoko Kato, Ikuo Tooyama
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] F-methyl-curcumin-1 (Shiga-Y5) はアルツハイマー病の画像診断や治療の候補化合物である2018
- Author(s)
  遠山育夫、柳沢大治郎、田口弘康
- Organizer
  第45回日本脳科学会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Curcumin derivative with C-4 substituent attenuated amyloid deposition, but did not affect tau pathology in mouse models.2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Lina Wati Durani, Hamizah Shahirah, Hamezah, Ikuo Tooyama
- Organizer
  Alzheimer’s Association International Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Application of double MR imaging for analysis of multiple pathological proteins in the brain of transgenic mouse model of Alzheimer’s disease2017
- Author(s)
  kuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第44回日本脳科学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease2017
- Author(s)
  Ikuo Tooyama, Anarmaa Mendsaikhan, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第４回モンゴル神経科学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] ocotrienol-rich fraction derived palm oil alleviates cognitive impairment and alters metabolite profiling in AβPP/PS1 Alzheimer’s disease mice model2017
- Author(s)
  Lina Wati Durani, Hamizah Shahirah Hamezah, Nor Faeizah Ibrahim, Daijiro Yanagisawa, Muhammad Luqman Nasaruddin, Masaki Mori, Hanafi Ahmad Damanhuri, Suzana Makpol, Wan Zurinah Wan Ngah, Ikuo Tooyama
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease2017
- Author(s)
  Ikuo Tooyama, Anarmaa Mendsaikhan, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第４回モンゴル神経科学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  Alzheimer's Association International Conference 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Application of double MR imaging for analysis of senile plaques and Aβ oligomers in the brain of APP/PS1 double transgenic mouse model of Alzheimer’s disease2017
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  中国微小脳循環学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Tau imaging using fluorine-19 MRI in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Ikuo Tooyama
- Organizer
  国際アルツハイマー病学会2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Application of double MR imaging for analysis of multiple pathological proteins in the brain of transgenic mouse model of Alzheimer’s disease.2017
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第44回日本脳科学会総会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy2017
- Author(s)
  aijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第12回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] フッ素MRIによるタウ病変のイメージング2017
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、遠山育夫
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy.2017
- Author(s)
  aijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第12回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MRIによるタウ病変のイメージング2017
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、遠山育夫
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] rain atrophy, cognitive functions and oxidative stress in aged rats.2017
- Author(s)
  Hamizah Shahirah Hamezah, Lina Wati Durani, Nor Faeizah Ibrahima, Daijiro Yanagisawa, Tomoko Kato, Akihiko Shiinoa, Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Ikuo Tooyama
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] アルツハイマー病の病態解明のためのフッ素MRIによるダブルプローブイメージング法の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第11回日本分子イメージング学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Development on Shiga-Y, a potential diagnostic and therapeutic agent for Alzheimer's disease, using mouse model of dementia2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Tomoko, Kato, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi
- Organizer
  第31回SAMサテライト国際シンポシウム
- Place of Presentation
  京都
- Year and Date
  2016-07-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] ッ素MR画像化法によるAβオリゴマーの検出の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] pplication of double MR imaging to detect amyloid oligomers in the brain of APP/PS1 transgenic model mice.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Tomoko Kato, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント、カナダ
- Year and Date
  2016-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] A novel curcumin derivative, f-methyl-curcumin-1 (fmec1), is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Tooyama, D. Yanagisawa, N. F. Ibrahim, H. Taguchi
- Organizer
  14th Meeting of Asia-Pacific Society for Neurochemistry
- Place of Presentation
  クアラルンプール、マレーシア
- Year and Date
  2016-07-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] -methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Tomoko Kato, Shieghiro Morikawa
- Organizer
  第57回日本神経学会総
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Application of double MR imaging to detect amyloid oligomers in the brain of APP/PS1 transgenic model mice2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Tomoko Kato, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント、カナダ
- Year and Date
  2016-07-22
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] アルツハイマー病の病態解明のためのフッ素MRIによるダブルプローブイメージング法の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第11回日本分子イメージング学
- Place of Presentation
  神戸
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MR画像化法によるAβオリゴマーの検出の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫:
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Tomoko Kato, Shieghiro Morikawa
- Organizer
  第57回日本神経学会総会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, and Ikuo Tooyama
- Organizer
  アルツハイマー病協会国際会議(AAIC)2015
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Styrylbenzoxazole and curcumin derivatives that have preferred features of a fluorine-19 MRI probe for amyloid imaging.2015
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikaw
- Organizer
  国際分子イメージング学会2015
- Place of Presentation
  米国ホノルル市
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, and Ikuo Tooyama
- Organizer
  アルツハイマー協会国際会議(AAIC）2015
- Place of Presentation
  米国ワシントンＤＣ
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Styrylbenzoxazole and curcumin derivatives that have preferred features of a fluorine-19 MRI probe for amyloid imaging.2015
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  国際分子イメージング学会2015
- Place of Presentation
  米国ホノルル市
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Effect of novel curcumin derivatives on amyloid aggregation and the cell toxicity2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Effect of novel curcumin derivatives on amyloid aggregation and the cell toxicity.2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] クルクミン誘導体によるアミロイドβ凝集抑制作用の解析2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Yanagisawa D, Ibrahim NF, Durani LW, Hamezah HS, Taguchi H, Morikawa S, Hirao K, Shirai N, Tooyama I.
- Organizer
  Alzheimer’s Association International Conference on Alzheimer’s Disease 2015,
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] Effect of novel curcumin derivatives on amyloid aggregation and the cell toxicity.2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Targeting Antioxidant Pathways in Neurodegeneration2015
- Author(s)
  Tooyama I
- Organizer
  第１回抗酸化物質ｓと細胞変性に関する国際会議
- Place of Presentation
  マレーシア国クアラルンプール市
- Year and Date
  2015-06-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, and Ikuo Tooyama
- Organizer
  アルツハイマー病協会国際会議(AAIC)2015
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Styrylbenzoxazole and curcumin derivatives that have preferred features of a fluorine-19 MRI probe for amyloid imaging.2015
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  国際分子イメージング学会2015
- Place of Presentation
  米国ホノルル市
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] argeting Antioxidant Pathways in Neurodegeneration2015
- Author(s)
  Ikuo Tooyama:
- Organizer
  第１回抗酸化物質ｓと細胞変性に関する国際会議
- Place of Presentation
  マレーシア国クアラルンプール市
- Year and Date
  2015-06-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] クルクミン誘導体によるAβ凝集抑制効果とAβによる細胞障害軽減効果の解析2014
- Author(s)
  柳沢大治郎、遠山育夫、Ibrahim, Nor Faeizah、田口弘康
- Organizer
  第11回サプリメント研究会
- Place of Presentation
  東京、日本
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイド斑の検出（その2）2013
- Author(s)
  Yanagisawa D, Morikawa S, Taguchi H, Shiino A, Inubushi T, Ibrahim NF, Tooyama I
- Organizer
  第36回日本神経科学会学術大会（Neuro2013）
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病遺伝子改変マウスの鼻粘膜Aβ42量は脳内Aβ42の蓄積量に比例する2013
- Author(s)
  遠山育夫、亀島直子、南條俊文、福原崇臣、柳沢大治郎
- Organizer
  第54回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-24111522
[Presentation] Preferable features of Fluorine-19 MRI probe required for amyloid detection in the brain2013
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Inubushi T, Ibrahim NF, Hirao K, Shirai N, Sogabe T, Tooyama I
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PUBLICLY-24111522
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイド斑の検出（その2）2013
- Author(s)
  柳沢大治郎、森川茂廣、田口弘康、椎野顯彦、犬伏俊郎、Nor Faeizah Ibrahim、遠山育夫
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-24111522
[Presentation] Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.2013
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Inubushi T, Ibrahim NF, Hirao K, Shirai N, Sogabe T, Tooyama I
- Organizer
  第15回国際アルツハイマー病会議 (AAIC2013)
- Place of Presentation
  米国ボストン
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] A novel 19F MRI probe for detecting amyloid deposition in Alzheimer’s disease2012
- Author(s)
  Ikuo Tooyama
- Organizer
  第５回ハルピン国際脳神経外科学会
- Place of Presentation
  中国ハルピン市
- Year and Date
  2012-07-13
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111522
[Presentation] クルクミン骨格をもつ高磁場MRI用アミロイドイメージング試薬の検討2012
- Author(s)
  遠山育夫
- Organizer
  第53回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] クルクミン骨格をもつ高磁場ＭＲ用アミロイドイメージング試薬の検討2012
- Author(s)
  遠山育夫
- Organizer
  第53回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Aβ deposition in the nasal cavity in the brain of a transgenic mouse model of Alzheimer's disease2012
- Author(s)
  Naoko Kameshima, Toshifumi Nanjou, Takaomi Fukuhara, Ikuo Tooyama
- Organizer
  アルツハイマー学会国際会議2012
- Place of Presentation
  カナダ、バンクーバー
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] A novel 19F MRI probe for detecting amyloid plaques in Alzheiemr's disease2012
- Author(s)
  Tooyama I
- Organizer
  The 5th Harbin International Neurosugery Conference
- Place of Presentation
  中国、ハルビン
- Invited
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Development of a simple and sensitive method for measurements of A,and its application to measure Aβ contents in human nasalsmea2012
- Author(s)
  Nanjo T, Kameshima N, Fukuhara T, Sogabe S, Tooyama I
- Organizer
  第14回国際アルツハイマー病会議(ICAD2012)
- Place of Presentation
  カナダバンクーバー市
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] A novel 19F MRI probe for detecting amyloid deposition in Alzheimer’s disease2012
- Author(s)
  遠山育夫
- Organizer
  The 5th Harbin International Neurosurgical Conference
- Place of Presentation
  中国、ハルピン市
- Invited
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin binding activity to B-amyloid oligomer2011
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイドの検出2011
- Author(s)
  柳沢大治郎、森川茂廣、田口弘康、椎野顕彦、犬伏俊郎、遠山育夫
- Organizer
  第34回日本神経科学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病とクルクミン2011
- Author(s)
  遠山育夫
- Organizer
  第5回認知症サプリメント研究会
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin binding activity to ss-amyloid oligomer2011
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo, T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病診断のための新規MR造影剤の開発2011
- Author(s)
  遠山育夫
- Organizer
  平成24年度神戸医師会学術講演会
- Place of Presentation
  神戸市(特別講演)(招待講演)
- Year and Date
  2011-04-09
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin derivatives for amyloid detection using 19F magnetic resonance imaging2011
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Development of highy accurate mesurements of Aβ using formic acid2011
- Author(s)
  Nanjo T, Tooyama I, Kameshima N, Fukuhara T
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイドの検出2011
- Author(s)
  柳沢大治郎、森川茂廣、田口弘康、椎野顕彦、犬伏俊郎、遠山育夫
- Organizer
  第34回日本神経科学会学術大会(Neuro2011)
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Aβ40 deposition in the nasal cavity of a transgenic mouse model of Alzheimer's disease2011
- Author(s)
  Kameshima N, Tooyama I, Fukuhara T, Kouge M, Nanjo T
- Organizer
  第13回国際アルツハイマー病会議 (ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] アルツハイマー病とクルクミン2011
- Author(s)
  遠山育夫
- Organizer
  第5回認知症サプリメント研究会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] アルツハイマー病の新しい診断基準とバイオマーカー研究について2011
- Author(s)
  遠山育夫
- Organizer
  湖北認知症セミナー(招待講演)
- Place of Presentation
  長浜
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] クルクミンのケトエノール互変異性とアミロイド親和性を利用したアルツハイマー病診断薬の検討2011
- Author(s)
  遠山育夫、柳沢大治郎、田口弘康
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病とクルクミン2011
- Author(s)
  遠山育夫
- Organizer
  第5回認知症サプリメント研究会
- Place of Presentation
  東京
- Year and Date
  2011-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病とクルクミン2011
- Author(s)
  遠山育夫
- Organizer
  第5回認知症サプリメント研究会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] パーキンソン病モデルラットにおけるfluoro-dopaのMR画像2010
- Author(s)
  遠山育夫、小田恵輔、柳沢大治郎、高田和幸、北村佳久、谷口隆之、森川茂廣、犬伏俊郎
- Organizer
  第5回日本分子イメージング学会総会・学術集会
- Place of Presentation
  大津市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] パーキンソン病モデルラットにおける fluoro-dopa のMR画像2010
- Author(s)
  遠山育夫, 小田恵輔, 柳沢大治郎, 高田和幸, 北村佳久, 谷口隆之, 森川茂廣, 犬伏俊郎
- Organizer
  第5回分子イメージング学会
- Place of Presentation
  大津市
- Year and Date
  2010-05-23
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Binding form of curcumin derivatives to B-amyloid aggregates2010
- Author(s)
  Ynagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第12回国際アルツハイマー病会議(ICAD2010)
- Place of Presentation
  米国ホノルル市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Binding form of curcumin derivatives to β-amyloid aggregates.2010
- Author(s)
  Yanagisawa D, Tooyama I, ほか
- Organizer
  第12回国際アルツハイマー病会議(ICAD2010)
- Place of Presentation
  米国ホノルル市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Interaction of the brain tissues with trifluoromethoxy-benzylated ligands for amyloid detection using 19F magnetic resonance imaging2008
- Author(s)
  Tomone Amatsubo, Shigehiro Morikawa, Keiko Matsuda, Toshiro Inubushi, Makoto Urushitani, Hiroyasu Taguchi, Nobuaki Shirai, Koichi Hirao, Masanari Kato, Kyuya Morino, Hirohiko Kimura, Ichiro Nakano, Chikako Yoshida, Takashi Okada, Mitsuo Sano, Ikuo Tooyama
- Organizer
  第10回国際アルツハイマー病会議(ICAD2008)
- Place of Presentation
  米国シカゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Bezoxazol derivatives containing trifluoromethoxy-benzyl amino group for amyloid detection in APP transgenic mice using ^<19>F magnetic resonance imaging2008
- Author(s)
  H Taguchi, T Amatsubo, S Morikawa, K Matsuda, N Shirai, K Hirao, M Kato, HMorino, H Kimura, I Nakano, C Yoshida, T Okada, MSano, I Tooyama
- Organizer
  第11回国際アルツハイマー病会議(ICAD2008)
- Place of Presentation
  米国シカゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Trifluoromethoxy-benzylated化合物と脳組織の相互作用による19Fシグナル強度の変化2008
- Author(s)
  雨坪知音、森川茂廣、松田敬子、田口弘康、白井伸明、平尾浩一、遠山育夫
- Organizer
  第3回日本分子イメージング学会総会・学術集会
- Place of Presentation
  さいたま市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] 統合失調症病態モデルとしての子宮内仮死経験ラットの検討.2007
- Author(s)
  和久田智靖, 松崎秀夫, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] アルツハイマー病の細胞治療法とMR画像法による投与細胞のin vivo追跡法2007
- Author(s)
  遠山育夫
- Organizer
  第34回日本脳科学会
- Place of Presentation
  出雲市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Immunohistochemical Mapping of NPR-A in the Brainstem of Macaca Fascicularis2007
- Author(s)
  E. M. Abdelalim, A. K. Osman, T. Takada, R. Torii, and I. Tooyama
- Organizer
  第30回日本神経科学会議
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18659110
[Presentation] 脳内神経再生の修飾による統合失調症の新しい治療法開発の試み.2007
- Author(s)
  松崎秀夫, 和久田智靖, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] 統合失調症病態モデルとしての子宮内仮死経験ラットの検討2007
- Author(s)
  和久田智靖, 松崎秀夫, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] MR tracking of transplanted neural cells using fluorinated poly-L-lysine-CF32007
- Author(s)
  Makoto Urushitani, Chiaki Masuda, Hiroyasu Taguchi, Shigehiro Morikawa, Toshiro Inubushi, Nobuaki Shirai, Koichi Hirao, Ikuo Tooyama
- Organizer
  第37回北米神経科学会議(Neuro2007)
- Place of Presentation
  米国サンディエゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] アルツハイマー病の細胞治療法とMR画像法による投与細胞のin vivo追跡法.2007
- Author(s)
  遠山育夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] 脳内神経再生の修飾による統合失調症の新しい治療法開発の試み2007
- Author(s)
  松崎秀夫, 和久田智靖, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim NF, Durani L, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I
- Organizer
  北米神経科学会議（Neuro2014)
- Place of Presentation
  ワシントンDC、米国
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Voxel Based Morphometry (VBM)評価方法によるアルツハイマー病の早期診断
- Author(s)
  古賀恒行、遠山育夫、森川茂廣、谷垣健二、椎野顯彦
- Organizer
  第42回日本磁気共鳴医学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-09-18 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] A novel 19F MRI probe for detecting amyloid deposition in Alzheimer’s disease.
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Akihiko Shiino, Toshiro Inubushi, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  アルツハイマー病国際学会（AAIC2014）
- Place of Presentation
  デンマークコペンハーゲン市
- Year and Date
  2014-07-14 – 2014-07-17
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Induction of mitochondrial ferritin by proinflammatory cytokines is mediated via NF-kappaB signaling pathway and involves in neuroprotection in Alzheimer’s disease.
- Author(s)
  H. YANG, H. GUAN, M. YANG, Z. LIU, S. ZHAO, S. TAKEUCHI, D. YANAGISAWA, S. R. VINCENT, I. TOOYAMA
- Organizer
  北米神経科学会（Neuroscience2014）
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] 高磁場MR 装置を利用したフッ素MRI アミロイドイメージングのためのstyrylbenzoxazole 誘導体の開発
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、椎野顯彦、犬伏俊郎、遠山育夫
- Organizer
  第9回日本分子イメージング学会学術集会
- Place of Presentation
  豊中市
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] 高磁場MR装置を利用したフッ素MRIアミロイドイメージングのためのstyrylbenzoxazole誘導体の開発
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、椎野顯彦、犬伏俊郎、遠山育夫
- Organizer
  第9回分子イメージング学会
- Place of Presentation
  大阪市豊中市
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Effect of novel curcumin derivatives on amyloid pathology in APP/PS1 mice
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第３７回日本神経科学大会(Neuroscience 2014)
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-11 – 2014-09-15
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice.
- Author(s)
  D. YANAGISAWA, H. TAGUCHI, N. IBRAHIM, L. DURANI1, S. MORIKAWA, K. HIRAO, N.　SHIRAI, T. SOGABE, I. TOOYAMA
- Organizer
  北米神経科学会（Neuroscience2014）
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Fluorine-19 MRI probe for detecting amyloid deposition in Alzheimer’s disease
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Shigehiro Morikawa, Akihiko Shiino, Koichi Hirao, Nobuaki Shirai,Takayuki Sogabe
- Organizer
  第３７回日本神経科学大会(Neuroscience 2014)
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-11 – 2014-09-15
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice.
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim N, Durani L, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I.
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, D. C., United States of America
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] Effect of novel curcumin derivatives on amyloid pathology in APP/PS1 mice
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第37回日本神経科学学会学術大会
- Place of Presentation
  横浜市、日本
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26290022

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Tooyama Ikuo 遠山 育夫

TOOYAMA Ikuo 遠山 育夫

Research Projects

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Simultaneous analysis of multiple abnormal brain proteins in Alzheimer's disease using multiple fluorine MR imagingPrincipal Investigator

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Development of AI technology to detect prion activity of pathogenic proteins in nasal mucosa and its application to diagnosis of dementiaPrincipal Investigator

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Simultaneous analysis of Aβ oligomers, Aβ fibrils and phosphrylated tau protein using fluroine-MRIPrincipal Investigator

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ケミカルシフトの違いを利用したフッ素MR画像による複数の脳内異常蛋白の同時解析Principal Investigator

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Development of novel diagnostic and therapeutic methods on Alzheimer's disease by targeting amyloid oligomersPrincipal Investigator

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Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.Principal Investigator

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Tooyama Ikuo 遠山育夫

TOOYAMA Ikuo 遠山育夫

フッ素ＭＲ画像法と光画像法によるアミロイドオリゴマーのｉｎ　ｖｉｖｏ病態解析Principal Investigator