Tooyama Ikuo 遠山育夫

… Alternative Names

Researcher Number	20207533
Other IDs
External Links
Affiliation (Current)	2018 : 滋賀医科大学, 神経難病研究センター, 教授
Affiliation (based on the past Project Information) *help	2015 – 2018 : 滋賀医科大学, 神経難病研究センター, 教授 2004 – 2015 : 滋賀医科大学, 分子神経科学研究センター, 教授 2005 : Shiga University of Medical Science, Faculty of Medicine, Professor, 医学部, 教授 2004 : 国立大学法人滋賀医科大学, 医学部, 教授 2003 : 滋賀医科大学, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Biomedical engineering/Biological material science / Biological Sciences / General anatomy (including Histology/Embryology) / Neurology / Neurochemistry/Neuropharmacology / Neuroscience in general / Nerve anatomy/Neuropathology / Experimental pathology Except Principal Investigator General anatomy (including Histology/Embryology) … More
Keywords	Principal Investigator アルツハイマー病 / 診断 / 核磁気共鳴画像 / 認知症 / 神経科学 / alternative splicing / ベータアミロイド / 脳神経疾患 / 治療 / FGF … More Except Principal Investigator 免疫組織化学 / mRNA / RT-PCR / c-fos / コリンアセチル基転移酵素 / immunohistochemistry / CNP / コリン神経 / Immunohistochemistry / ラット / vasopressin / バソプレッシン / メニエール病 / cDNA / 核酸 / 敗血症性脳症 / Cholinergic / アセチルコリン / 内リンパ水腫 / PCR法 / アルツハイマー病 / バゾプレッシン / inner ear / 分子生物学 / 水代謝 / Meniere's disease / 疫学 / 上腸間膜動脈閉塞症 / rat brain / 内耳 / ラット脳 / ホスホロチオエート・オリゴ / molecular biology / 脳 / endolymphatic hydrops / in situハイブリダイゼーション / 抗利尿ホルモン / Electron microscopy / 選択的スプライシング / c-fos、 / ホスホロチオエ-トオリゴ / アクアポリン / T7プロモーター / 成長因子受容体 / 13C-MR / 遺伝子発現 / 嗅粘膜 / 神経画像 / electron microscopy / 循環器・高血圧・疫学 / オキシトシン / タウリン抗体 / Fibroblast growth factor / Cholinergic system / 可塑性 / ナノ粒子 / phosphorylated c-jun / bFGF / 体性運動野 / FGF / デルトルフィン / 循環器・高血圧疫学 / 内耳水代謝 / 精神生理学 / アミロイドβ / 電子顕微鏡 / 生後発達 / 細胞標識 / 共存 / alternative splicing / 脳卒中 / phosphorylated c-Jun / MRI / 神経科学 / プローブ / 脳機能解析 / 過活動膀胱 / dopaminergic / 蛍光プローブ / Taurine / 末梢神経疾患 / 早期診断 / 蛍光 / c-Fos / VIP / c-jun / CRNA増幅法 / 脳神経疾患 / 自動合成機 / Mouse / biotin phosphoramidite / opioid / アルツハイマーモデル / 一般女性 / バレル構造 / PCR / 脳代謝画像 / 人類遺伝学 / Carbon tetrachloride / マウス / Colooalization / NADPH diaphorase / Water regulation / cRNA増幅法 / 神経幹細胞 / 動物モデル / スプライシング / 統合失調症 / 四塩化炭素 / vertigo / Adenosine deaminase / Rat / endotoxin / 社会医学 / エンドトキシン / in situハイブリダイゼ-ション / Nitric oxide synthase / 頭部MRI / deltorphine / 女性 / 逆転写 / Alzheimer's Disease / 神経変性 / 転写因子 / 神経ペプチド / 下部尿路障害 / 幹細胞 / in situ hybrydization / SIRS / 神経伝達物質 / 転写障害 / parasympathetic nervous system / cholinergic neurons / Inner ear / regulation system of inner ear fluid / ヒスチジン脱炭酸酵素 / 診断薬 / グルコース代謝 / Vasopressin / プロ-ブ / 利尿ホルモン / コリン作動性 / Histidine decarboxylase / systemic inflammatory response syndrome / antibody / in situ hybridization / 画像解核 / 胆汁酸 / タウリン / 有機化学 / 脊髄グリア細胞 / 網膜神経節細胞 / アデノシンデアミネース / ミトコンドリア / Meniere disease / ポリチミジン・オリゴヌクレオテド / ヒト鼻腔 / アンチセンスRNA / 下部尿路機能障害 / 肝 / histochemistry / 超常磁性鉄 / HVJ-E / コリン作動性神経 / Alternative splicing / RNAポリメラーゼ / 組胞画像 / c‐fos / FGF受容体 / monoclonal / Liver / タウロコ-ル酸 / 発現制御 / occlusion of the superior mesenteric artery / 排尿学 / Taurine antibody / ポリチミジン・オリゴヌクレオチド / 視覚野 / 肝臓 / アストロサイト / 亜酸化窒素 / Antigen preparation / タウ蛋白 / probe design / antisense oligonucleotide / brain / quantitative image analysis / 老人斑 / Antibody to acetylcholine / メニニール病 / CLP / 脳機能解析法 / ビオチン / Acetylcholine / APPマウス / choline acetyltransferase / 脳萎縮 / セロトニン / primers / シナプス / 13C-NMR / 間質性膀胱炎 / 副交感神経 / 組織化学 / aFGF / 免疫組織学 / 神経回路 / PCR method / 循環器・高血圧 / 組織固定 / 痴呆症 / 線維芽細胞成長因子 / 視床下部 / image analysis / MAP2 / 痴呆 / プライマー / Neurotransmitter / 画像解析 / Glia / reverse transcription / 予防 / 常時性鉄粒子 / 総合失調症 / c-Jun / バゾブレッシン / 動脈硬化 / 細胞 / バソプレシン / retinal ganglion cells / コホート研究 / Brain / CNS / Bile acids / 潜在性動脈硬化 / 遺伝子 / NADPHジアホラ-ゼ / アストログリア / 近赤外 / アンチセンス・オリゴヌクレオチド / 神経 / 分子イメージング / 老化 / 末梢神経 / バンプレッシン / 隆起乳頭体核 / inner ear fluid regultion / コリン神経脱落 / アルツハイマ-病 / 認知症 / めまい / 生後発育 / モノクローナル抗体 / Senile plaque / 核磁気共鳴画像 / polyclonal / 分子変換 / Hypothalamus / １３C-NMR / アセチルコリン抗体 / 黒質線条体 / コリン神経系 / 再生医療 Less

Simultaneous analysis of Aß oligomers, Aß fibrils and phosphrylated tau protein using fluroine-MRIPrincipal InvestigatorOngoing
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
神経難病診断のためのMR画像用試薬の開発Ongoing
- Principal Investigator
  
  田口弘康
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shiga University of Medical Science
Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in COX6A1
- Principal Investigator
  
  Makino Satoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tohoku University
Subclinical atherosclerosis and brain atrophy in the general Japanese women
- Principal Investigator
  
  Miura Katsuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hygiene and public health
- Research Institution
  Shiga University of Medical Science
ケミカルシフトの違いを利用したフッ素MR画像による複数の脳内異常蛋白の同時解析Principal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Development of novel diagnostic and therapeutic methods on Alzheimer's disease by targeting amyloid oligomersPrincipal Investigator
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.Principal Investigator
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Study of a highly sensitive C-13 MR glucose metobolite mapping with the brain of an Altzheimer model mouse
- Principal Investigator
  
  Morikawa Shigehiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Shiga University of Medical Science
Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
フッ素ＭＲ画像法と光画像法によるアミロイドオリゴマーのｉｎ　ｖｉｖｏ病態解析Principal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
General transcription factor TAF1 is involved in transcriptional impairment and neurodegeneration
- Principal Investigator
  
  MAKINO Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tohoku University
  Yamagata University
Central sensitization mechanism depends on microglia participates in Lower Urinary Tract Symption
- Principal Investigator
  
  TSURU Teruhiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Shiga University of Medical Science
Comparison Western Japan with Eastern Japan about the cause of asymptomatic cerebrovascular disorders and hippocampal atrophy in general Japanese men
- Principal Investigator
  
  MIURA Katsuyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Shiga University of Medical Science
Development of hemodiagnostic methods for Alzheimer's disease using curcuimin derivativesPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Development of amyloid imaging using fluorine-MRIPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shiga University of Medical Science
Research on production of a primate model for schizophrenia and development of transplant therapy by neural stem cell grafts
- Principal Investigator
  
  MORI Norio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Hamamatsu University School of Medicine
Development of diagnostic methods for Parkinson disease using high fieled magnetic resonance imagingPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shiga University of Medical Science
ES細胞をししたアルツハイマー病モデルサルの作成Principal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Shiga University of Medical Science
Non-invasive MRI tracking of labeled stem cells and its application to regenerative medicine
- Principal Investigator
  
  INUBUSHI Toshiro
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shiga University of Medical Science
Novel cholineacetyltransferase variants (pChAT) in the brain of human and monkeyPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
A study for regulation of inner ear fluid using molecular biology metod
- Principal Investigator
  
  KITANO Hiroya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tottori University
Study on novel cholinergic pathways in the brain of patients with Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Shiga University of Medical Science
Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rats
- Principal Investigator
  
  KIMURA Hisoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
Localization of peptides that regulate inner ear fluid in the rat
- Principal Investigator
  
  KITANO Hiroya
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
神経細胞の核内転写因子の人工制御による脳機構の解明Principal Investigator
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neuroscience in general
- Research Institution
  Shiga University of Medical Science
Studies on Neuronal mRNA Splicing
- Principal Investigator
  
  YASUHARA Osamu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
Study on the central nervous system of rat with systemic inflammatory response syndrome (SIRS)
- Principal Investigator
  
  HASE Takanori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shiga University of Medical Science
生体内増幅アンチセンスRNAを用いる脳機能解析法の開発
- Principal Investigator
  
  YASUHARA Osamu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
Expression of fluid regulation peptides in the inner ear.
- Principal Investigator
  
  KITANO Hiroya
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga Universityof Medical Science
Development of in situ PCR method and its application to histochemistry
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shiga University of Medical Science
Localization and function of acidic fibroblast growth factor in adrenal glandPrincipal Investigator
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shiga University of Medical Science
Joint study on deltorphines in the mammalian brain
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Shiga University of Medical Science
"Expression of c-fos protein in rat brain after occlusion of superior mesenteric artery (immunohistochemical investigation)"
- Principal Investigator
  
  HASE Takanobu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shiga University of Medical Science
Non-radioactive in situ hybridization histochemistry using chemically defined boitin-labeled probes.
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shiga University of Medical Science(SUMS)
Molecular neurobiological study on the deterioration of specific genes for dementia of Alzheimer type
- Principal Investigator
  
  HIMURA Hiroshi
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Shiga University of Medical Science
Taurine Immunohistochemistry in the Liver
- Principal Investigator
  
  OCHI Junzo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shiga University of Medical Science
シナプス形成に関するモノアミン神経の機能形態学的研究
- Principal Investigator
  
  木村宏
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Shiga University of Medical Science
IMMUNOHISTOCHEMICAL STUDY OF THE CENTRAL CHOLINERGIC SYSTEM BY USING ANTIBODY TO ACETYLCHOLINE.
- Principal Investigator
  
  KIMURA Hiroshi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  神経解剖学
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE

[Book] FRUITS, VEGETABLES AND HERBS: Bioactive Foods in Health Promotion2017
- Author(s)
  Ikuo Tooyama, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Hiroyasu Taguchi and Daijiro Yanagisawa
- Total Pages
  593
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-15K01282
[Book] Curcumin against amyloid pathology in mental health and brain composition.; In Health Fruits, Vegetables, and Herbs: Bioactive Foods in Promoting Edited by Ronald Watson and Victor Preedy2016
- Author(s)
  Ikuo Tooyama, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Hiroyasu Taguchi, Daijiro Yanagisawa
- Total Pages
  19
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26640042
[Book] FRUITS, VEGETABLES AND HERBS: Bioactive Foods in Health Promotion2016
- Author(s)
  Tooyama I, Ibrahim NF, Durani LW, Haemzah HS, Damanhuri MHA, Wan Ngah WZ, Taguchi H, Yanagisawa D
- Total Pages
  593
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26290022
[Book] 神経内科学テキスト改訂第2版(分担執筆)2005
- Author(s)
  遠山育夫
- Total Pages
  10
- Publisher
  南江堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice.2017
- Author(s)
  Ibrahim NF, Yanagisawa D, Durania LW, Hamezaha HS, HDamanhuri HD, Wan Ngahb WZ, Tsuji M, Kiuchi Y, Ono K, Tooyama I
- Journal Title
  
  J Alzheimers Dis
  
  Volume : 55 Pages : 597-617
- DOI
  10.3233/jad-160685
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26461266, KAKENHI-PROJECT-15K16321
[Journal Article] Fluorine-19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice2017
- Author(s)
  Yanagisawa Daijiro、Ibrahim Nor Faeizah、Taguchi Hiroyasu、Morikawa Shigehiro、Kato Tomoko、Hirao Koichi、Shirai Nobuaki、Sogabe Takayuki、Tooyama Ikuo
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume : 96 Pages : 841-851
- DOI
  10.1002/jnr.24188
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01282, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K01563, KAKENHI-PROJECT-26282145, KAKENHI-PROJECT-17H03560
[Journal Article] Fluorodopa is a promising fluorine-19 MRI probe for evaluating striatal dopaminergic function in a rat model of Parkinson’s disease2017
- Author(s)
  Yanagisawa D, Oda K, Inden M, Morikawa S, Inubushi T, Taniguchi T, Hijioka M, Kitamura Y, Tooyama I
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume : 印刷中
- DOI
  10.1002/jnr.23983
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-15K16321
[Journal Article] Mitochondrial ferritin protects SH-SY5Y cells against H 2 O 2 -induced oxidative stress and modulates α-synuclein expression2017
- Author(s)
  Hongpeng Guan, HongKuan Yang, Mingchun Yang, Daijiro Yanagisawa, Jean-Pierre Bellier, Masaki Mori, Shogo Takahata, Takashi Nonaka, Shiguang Zhao, Ikuo Tooyama.
- Journal Title
  
  Exp Neurol.
  
  Volume : 291 Pages : 51-61
- DOI
  10.1016/j.expneurol.2017.02.001
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01486, KAKENHI-PROJECT-15K15387, KAKENHI-PROJECT-15K08327
[Journal Article] Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM.2017
- Author(s)
  Shiino A, Chen Y-W, Tanigaki K, Yamada A, Vigers P, Watanabe T, Tooyama I, Akiguchi I
- Journal Title
  
  Scientific Reports
  
  Volume : 3 Pages : 39818-39818
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum2017
- Author(s)
  Durani Lina Wati、Hamezah Hamizah Shahirah、Ibrahim Nor Faeizah、Yanagisawa Daijiro、Makpol Suzana、Damanhuri Hanafi Ahmad、Tooyama Ikuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume : 493 Pages : 1356-1363
- DOI
  10.1016/j.bbrc.2017.09.164
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560
[Journal Article] Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions2017
- Author(s)
  Hamezah Hamizah Shahirah、Durani Lina Wati、Ibrahim Nor Faeizah、Yanagisawa Daijiro、Kato Tomoko、Shiino Akihiko、Tanaka Sachiko、Damanhuri Hanafi Ahmad、Ngah Wan Zurinah Wan、Tooyama Ikuo
- Journal Title
  
  Experimental Gerontology
  
  Volume : 99 Pages : 69-79
- DOI
  10.1016/j.exger.2017.09.008
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560
[Journal Article] Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis.2016
- Author(s)
  Yang M, Yang H, Guan H, Bellier JP, Zhao S, Tooyama I
- Journal Title
  
  Neuroscience
  
  Volume : 328 Pages : 92-106
- Acknowledgement Compliant / Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Amyloid imaging using fluorine-19 magnetic resonance imaging (19F-MRI)2016
- Author(s)
  Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S
- Journal Title
  
  Ageing Research Review
  
  Volume : 15 Pages : 1568-1637
- DOI
  10.1016/j.arr.2015.12.008
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01282, KAKENHI-PROJECT-15K16321, KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-24240071, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26282145
[Journal Article] Inhalable Curcumin: Offering the Potential for Translation to Imaging and Treatment of Alzheimer's Disease.2015
- Author(s)
  McClure R, Yanagisawa D, Stec D, Koktysh D, Xhillari D, Jaeger R, Chekmenev E, Tooyama I, Gore JC, Pham W.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume : 44 Pages : 283-295
- DOI
  10.3233/jad-140798
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670554, KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid ß aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochem Biophys Report
  
  Volume : 4 Pages : 357-368
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] Up-regulation of mitochondrial ferritin by proinflammatory cytokines: Implications for a role in Alzheimer’s disease.2015
- Author(s)
  Yang H, Guan H, Yang M, Liu Z, Takeuchi S, Yanagisawa D, Vincent SR, Zhao S, Tooyama I
- Journal Title
  
  J Alzheimer's Disease
  
  Volume : 45 Pages : 797-811
- DOI
  10.3233/jad-142595
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid β aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochem Biophys Report
  
  Volume : 4 Pages : 357-368
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds.2015
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Australian Journal of Chemistry
  
  Volume : 68 Pages : 224-229
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Synthesis and tautomerism of curcumin derivatives and related compounds.2015
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Aust. J. Chem.
  
  Volume : 68 Pages : 224-229
- DOI
  10.1071/ch14464
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25750159, KAKENHI-PROJECT-26670554, KAKENHI-PROJECT-26282145, KAKENHI-PROJECT-24240020
[Journal Article] Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice.2015
- Author(s)
  Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I
- Journal Title
  
  Neurobiol Aging
  
  Volume : 36 Pages : 201-210
- DOI
  10.1016/j.neurobiolaging.2014.07.041
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25750159, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554, KAKENHI-PROJECT-26282145, KAKENHI-PROJECT-24240020, KAKENHI-PUBLICLY-26111709
[Journal Article] Diagnosis of amyloid-positive mild cognitive impairment using structural magnetic resonance imaging: the worth of multiple regions of interest.2015
- Author(s)
  Vigers P, Shiino A, Tooyama I
- Journal Title
  
  Integrative Molecular Medicine
  
  Volume : 2 Pages : 205-213
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid β aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume : 4 Pages : 357-368
- DOI
  10.1016/j.bbrep.2015.10.009
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16321, KAKENHI-PROJECT-26670554
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid ß aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochem Biophys Report
  
  Volume : 4 Pages : 357-368
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01282
[Journal Article] ynthesis and Tautomerism of Curcumin Derivatives and Related Compounds.2015
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Australian Journal of Chemistry
  
  Volume : 68 Pages : 224-229
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.2015
- Author(s)
  Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I
- Journal Title
  
  Neurosci Lett.
  
  Volume : 591 Pages : 19-24
- Publisher
  Elsevier
- DOI
  10.1016/j.neulet.2015.02.013
- PMID
  25676811
- ISSN
  0304-3940
- Year and Date
  2015-03-30
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-26290022, KAKENHI-PUBLICLY-26111709
[Journal Article] フッ素ＭＲ画像法によるアミロイドオリゴマーのin vivo病態解析2014
- Author(s)
  遠山育夫、柳沢大治郎、NOr Faeizah Ibrahim, 田口弘康
- Journal Title
  
  遺伝子医学MooK
  
  Volume : 26 Pages : 190-194
- Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26111709
[Journal Article] Development of a method to measure Aβ42 in nasal cavity samples and its appilication in normal human volunteers.2014
- Author(s)
  Nanjo T, Fukuhara T, Kameshima N, Yanagisawa D, Shimizu S, Shimizu T, Shiino A, Akatsu H, Yamamotyo T, Tooyama I
- Journal Title
  
  Journal of Brain Science
  
  Volume : 4 Pages : 5-23
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640042
[Journal Article] mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.2014
- Author(s)
  Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K.
- Journal Title
  
  10.1016/j.ajhg.2014.07.013.
  
  Volume : 95 Pages : 294-300
- DOI
  10.1016/j.ajhg.2014.07.013
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590400, KAKENHI-PROJECT-24592441, KAKENHI-PUBLICLY-25129701, KAKENHI-PROJECT-25293041, KAKENHI-PROJECT-25460403, KAKENHI-PROJECT-25461537, KAKENHI-PROJECT-25670087, KAKENHI-PROJECT-25860842, KAKENHI-PROJECT-25870074, KAKENHI-PROJECT-26870067
[Journal Article] Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.2014
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Sogabe T, Toovama I
- Journal Title
  
  J Alzheimer’s Dis
  
  Volume : 39 Pages : 617-631
- DOI
  10.3233/jad-131025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-23300188, KAKENHI-PUBLICLY-24111522, KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-24240071, KAKENHI-PROJECT-25750159
[Journal Article] Knockdown of p53 suppresses Nanog expression in embryonic stem cells.2013
- Author(s)
  Abdelalim EM, Tooyama I.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 443 Pages : 652-657
- DOI
  10.1016/j.bbrc.2013.12.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590400
[Journal Article] Distinct localization of peripheral and central types of choline acetyltransfer ase in the rat cochlea2013
- Author(s)
  Kitanishi T, Aimi Y, Kitano H, Suzuki M, Kimura H, Saito A, Shimizu T, Tooyama I
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume : 46 Issue : 5 Pages : 145-152
- Publisher
  Japan Society of Histochemistry and Cytochemistry
- DOI
  10.1267/ahc.13021
- PMID
  24194628
- ISSN
  0044-5991
- Year and Date
  2013-10-30
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway2013
- Author(s)
  Kameshima, N., Yanagisawa, D., Tooyama, I.
- Journal Title
  
  Neuroscience Research
  
  Volume : 76 Pages : 169-172
- DOI
  10.1016/j.neures.2013.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111522
[Journal Article] Visualizing hepatic copper release in Long-Evans cinnamon rats using single-photon emission computed tomography.2013
- Author(s)
  Yezdimer, E.M., Umemoto, T., Yamada, H., Makino, S., Tooyama I
- Journal Title
  
  Appl Biochem Biotechnol
  
  Volume : 170 Pages : 1138-1150
- DOI
  10.1007/s12010-013-0252-9
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111522, KAKENHI-PROJECT-24590400
[Journal Article] Mitochondrial ferritin in neurodegenerative diseases.2013
- Author(s)
  Yang, H., Yang, M., Guan, H., Liu, Z., Zhao, S., Takeuchi, S., Yanagisawa, D., Tooyama. I.
- Journal Title
  
  Neurosci Res
  
  Volume : 77 Pages : 1-7
- DOI
  10.1016/j.neures.2013.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111522, KAKENHI-PROJECT-24590400
[Journal Article] Generation of a Monoclonal Antibody Specifically Reacting with Neuron-specific TATA-Box Binding Protein-Associated Factor 1 (N-TAF1).2013
- Author(s)
  Makino S, Masuda C, Ando S, Tamiya G, Tooyama I.
- Journal Title
  
  Antibodies
  
  Volume : 2 Pages : 1-8
- DOI
  10.3390/antib2010001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590300, KAKENHI-PROJECT-24590400, KAKENHI-PUBLICLY-24112702
[Journal Article] Correlation of A β deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease2012
- Author(s)
  Kameshima N, Nanjou T, Fukuhara T, Yanagisawa D, Tooyama I
- Journal Title
  
  Neurosci Lett
  
  Volume : 513 Pages : 166-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650192
[Journal Article] Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease.2012
- Author(s)
  亀島直子
- Journal Title
  
  Neurosci Lett
  
  Volume : 513 Pages : 166-169
- DOI
  10.1016/j.neulet.2012.02.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07718, KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-23650192
[Journal Article] UBR5 gene mutation is associated with familial adult myoclonic epilepsy in a Japanese family.2012
- Author(s)
  Kato T, Tamiya G, Koyama S, Nakamura T, Makino S, Arawaka S, Kawanami T, Tooyama I.
- Journal Title
  
  ISRN Neurol
  
  Volume : 2012 Pages : 508308-508308
- DOI
  10.5402/2012/508308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590300, KAKENHI-PROJECT-24590400, KAKENHI-PUBLICLY-24112702
[Journal Article] In vivo detection of copper ions by magnetic resonance imaging using a prion-based contrast agent.2012
- Author(s)
  Makino S
- Journal Title
  
  Appl Biochem Biotechnol
  
  Volume : 168 Pages : 504-518
- DOI
  10.1007/s12010-012-9792-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-24590400
[Journal Article] アルツハイマー病診断のための新規MR造影剤の開発2012
- Author(s)
  遠山育夫
- Journal Title
  
  神戸医師会報
  
  Volume : 2月号 Pages : 51-57
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] In vivo detection of amyloid b deposition using 19F magnetic resonance imaging with a 19F-containing curcumin derivative in a mouse model of Alzheimer’s disease.2011
- Author(s)
  柳沢大治郎、遠山育夫ほか
- Journal Title
  
  Neuroscience
  
  Volume : 184 Pages : 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650192
[Journal Article] 核磁気共鳴画像によるアミロイドイメージング用トレーサー2011
- Author(s)
  遠山育夫, 田口弘康、柳沢大治郎
- Journal Title
  
  鳥取医療
  
  Volume : 4 Pages : 68-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] In vivo detection of amyloid β deposition using 19F magnetic resonance imaging with a 19F-containing curcumin derivative in a mouse model of Alzheimer's disease2011
- Author(s)
  Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitania M, Shirai N, Hirao K, Shiino A, Inubushid T, Tooyama I
- Journal Title
  
  Neuroscience
  
  Volume : 184 Pages : 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650192
[Journal Article] Curcuminoid binds to amyloid β(1-42) oligomer and fibril.2011
- Author(s)
  Yanagisawa H, Taguchi H, Yamamoto A, Shirai N, Hirao K, Tooyama I
- Journal Title
  
  J Alzheimers Dis
  
  Volume : (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex2011
- Author(s)
  Wang L, Yang H, Zhao S, Sato H, Konishi Y, Beach TG, Abdelalim EM, Bisem NJ, Tooyama I
- Journal Title
  
  PLoS ONE
  
  Volume : 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina2010
- Author(s)
  Abdelalim EM, Tooyama I
- Journal Title
  
  Peptides 31
  
  Pages : 180-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Relationship between the tautomeric structures of curcumin derivatives and their A β-binding activities in the context of therapies for Alzheimer's disease.2010
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada K N, Yamamoto A, Tooyama I
- Journal Title
  
  Biomaterials
  
  Volume : 31 Pages : 4179-4185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] Amyloid imaging using high-filed magnetic resonance.2010
- Author(s)
  Amatsubo T, Yanagisawa D, Morikawa S, Tooyama I
- Journal Title
  
  Magn Reson Med Sci
  
  Volume : 9 Pages : 95-99
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder2009
- Author(s)
  Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
- Journal Title
  
  Am J Med Genet B Neuropsychiatr Genet. 150B(7)
  
  Pages : 967-976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] 動物モデルを使った高磁場MRIによる認知症診断の可能性2009
- Author(s)
  遠山育夫, 田口弘康, 雨坪知音, 森川茂廣
- Journal Title
  
  Cognition and Dementia 8
  
  Pages : 53-57
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19) F magnetic resonance imaging.2009
- Author(s)
  Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I.
- Journal Title
  
  Neurosci Res. 63
  
  Pages : 76-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging2009
- Author(s)
  Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I.
- Journal Title
  
  Neurosci Res 63
  
  Pages : 76-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging.2009
- Author(s)
  Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I.
- Journal Title
  
  Neurosci Res 63
  
  Pages : 76-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury.2009
- Author(s)
  Yanagida T, Tsushima J, KitamuraY, Yanagisawa D, Takata T, Shibaike T, Yamamoto A, Taniguchi T, Yasui H, Taira T, Morikawa S, Inubhi T Tooyama I, Ariga H
- Journal Title
  
  Oxidative Medicine and Cellular Longevity 2
  
  Pages : 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using 19F magnetic resonance imaging2009
- Author(s)
  Amatsubo T, Morikawa S, Matsuda K, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I
- Journal Title
  
  Neurosci Res 63
  
  Pages : 76-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Application of microglia to possible cell therapy for Alzheimer's disease2009
- Author(s)
  Ikuo Tooyama, Hiroaki Nakahara, Song Yang
- Journal Title
  
  鳥取臨床医学 2
  
  Pages : 142-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury.2009
- Author(s)
  Yanagida T, Tsushima J, Kitamura Y, Yanagisawa D, Takata T, Shibaike T, Yamamoto A, Taniguchi T, Yasui H, Morikawa S, Inubiushi T, Tooyama I, Agira H
- Journal Title
  
  Oxid Med Cell Longev. 2
  
  Pages : 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2(PCNT2) in bipolar disorder2008
- Author(s)
  Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Tohyama M, Yoshikawa T, Mori N.
- Journal Title
  
  Biol Psychiatry 63(7)
  
  Pages : 678-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] 高次機能心の障害を科学する2008
- Author(s)
  遠山正彌, 森則夫
- Journal Title
  
  脳21 11(1)
  
  Pages : 65-71
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats.2008
- Author(s)
  Yanagisawa D, Kitamura Y, Inden M, Takata K, Taniguchi T, Morikawa S, Morita M, Inubushi T, Tooyama L, Taira T, Iguchi-Ariga SM, Akaike A, Ariga H
- Journal Title
  
  J Cereb Blood Flow Metab 28
  
  Pages : 563-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Fluorine-19 Fast Recovery Fast Spin Echo Imaging for Mapping of 5-Fluorouracil2008
- Author(s)
  Morikawa S, Inubushi T, Morita M, Murakami K, Masuda C, Maki J, Tooyama I
- Journal Title
  
  Magn Resn Med Sci 6
  
  Pages : 235-240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization2008
- Author(s)
  Kubota K, Kumamoto N, Matsuzaki S. Hashimoto R, Hattori T, Okuda H, Takam H, Taked M, Katayama T, Tohyama M.
- Journal Title
  
  Biochem Biophys Res Commun 379
  
  Pages : 191-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons.2008
- Author(s)
  Abdelalim EM, (4名省略) Mori N, Tooyama I.
- Journal Title
  
  Neuroscience 155(1)
  
  Pages : 192-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] 【21世紀の脳科学をみすえて】高次機能心の障害を科学する2008
- Author(s)
  遠山正彌, 森則夫
- Journal Title
  
  脳21 11巻1号
  
  Pages : 65-71
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Microglial transplantation increases amyloid-β clearance in Alzheimer model rats.2007
- Author(s)
  Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M Inubushi T, Tsuichiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I
- Journal Title
  
  FEBS Letters 581
  
  Pages : 475-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659110
[Journal Article] Immunohistochemical mapping of NPR-A in the brainstem of Macaca Fascicularis.2007
- Author(s)
  Abdelalim EM, Osman, AHK, Takada T, Torii R, Tooyama I
- Journal Title
  
  Neuroscience 145
  
  Pages : 1087-1096
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Immunohistochemical mapping of natriuretic peptide receptor-A in the brainstem of Macaca fascicularis.2007
- Author(s)
  Abdelalim EM, Osman AH, Takada T, Torii, Tooyama I
- Journal Title
  
  Neuroscience 145
  
  Pages : 1087-1096
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.2007
- Author(s)
  Kimura S, Bellier J-P, Matsuo A, Tooyama I, Kimura H
- Journal Title
  
  Neurochem Internatinal 50
  
  Pages : 251-255
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Magnetic resonance imaging using hemagglutinating virus of Japan-envelope vector successfully detects localization of intra-cardially administered microglia in normal mouse brain2007
- Author(s)
  Song Y, Morikawa S, Morita M, Inubushi T, Takada T, Torii R, Tooyama I.
- Journal Title
  
  Neurosci Lett. 395(1)
  
  Pages : 42-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] ミクログリア研究の新しい展開アルツハイマー病の細胞治療法の可能性.2007
- Author(s)
  遠山育夫.
- Journal Title
  
  Dementia Japan 21(3)
  
  Pages : 261-269
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Fluorine-19 fast recovery fast spin echo imaging for mapping 5-fluorouracil2007
- Author(s)
  Morikawa S, Inubushi T, Morita M, Murakami K, Masuda C, Maki J, Tooyama I.
- Journal Title
  
  Magnetic Resonance Medical Science 6(4)
  
  Pages : 235-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209039
[Journal Article] Fluorine-19 fast recovery fast spin echo imaging for mapping 5-fluorouracil2007
- Author(s)
  Morikawa S, Inubushi T, Morita M, Murakami K, Masuda C, Maki J, Tooyama I.
- Journal Title
  
  Magn Reson Med Sci. 6(4)
  
  Pages : 235-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] The MR tracking of ATDC5 cells using fluorinated poly-L-Lysine-CF3.2007
- Author(s)
  Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I.
- Journal Title
  
  Biomaterials 28
  
  Pages : 434-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats2007
- Author(s)
  Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M, Inubushi T, Tsuchiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I
- Journal Title
  
  FEBS Lett. 581(3)
  
  Pages : 475-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.2007
- Author(s)
  Kimura S, Bellier J-P, Matsuo A, Tooyama I, Kimura H
- Journal Title
  
  Neurochemical International 581
  
  Pages : 251-255
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Molecular Cloning of BNP from heart and its immunohistochemical localization in the hypothalamus of monkey2006
- Author(s)
  EM Abdelalim, T Takada, Ryuzo Torii, I Tooyama
- Journal Title
  
  Peptides 27
  
  Pages : 1886-1893
- Data Source
  KAKENHI-PROJECT-18659110
[Journal Article] In vitro expression of natriuretic peptides in cardiomyocytes differentiated from monkey embryonic stem cells.2006
- Author(s)
  Abdelalim EM, Takada T, Toyoda F, Omatsu-Kanbe M, Matsuura H, Tooyama I, R Torii.
- Journal Title
  
  Biochem Biophys Res Commun 340
  
  Pages : 689-695
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Localization of fibroblast growth factor-1 (FGF1) in cholinergic neurons innervating the rat larynx.2006
- Author(s)
  Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I
- Journal Title
  
  J Histochem Cytochem 54
  
  Pages : 1061-1067
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Localization of fibroblast growth factor-1 (FGF1) in cholinergic neurons innervating the rat larynx.2006
- Author(s)
  Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I
- Journal Title
  
  Journal of Histochemistry and Cytochemistry 54
  
  Pages : 1061-1067
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Localization of fibroblast growth factor-1(FGF1) in cholinergic neurons innervating the rat larynx.2006
- Author(s)
  Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I
- Journal Title
  
  J Histochem Cytochem 54
  
  Pages : 1061-1067
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Molecular Cloning of BNP from Heart and Its Immunohistochemical Localization in the Hypothalamus of Monkey.2006
- Author(s)
  Abdelalim EM, Takada T, Torii R, Tooyama I
- Journal Title
  
  Peptides 27
  
  Pages : 1886-1893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain2006
- Author(s)
  Song Y, Morikawa S, Inubushi T, Takada T, Torii R, Kitamura Y, Taniguchi T, Tooyama I.
- Journal Title
  
  Histol Histopathol 21
  
  Pages : 705-711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] In Vitro Expression of Natriuretic Peptides in Cardiomyocytes Differentiated from Monkey Embryonic Stem Cells2006
- Author(s)
  EM Abdelalim, T Takada, F Toyoda, M Omatsu, H Matsuura, I Tooyama, Ryuzo Torii
- Journal Title
  
  Biochemical Biophysical Research Communications 340
  
  Pages : 689-695
- Data Source
  KAKENHI-PROJECT-18659110
[Journal Article] Molecular Cloning of BNP from Heart and Its Immunohistochemical Localization in the Hypothalamus of Monkey.2006
- Author(s)
  Abdelalim EM, Takada T, Torii R, Tooyama I
- Journal Title
  
  Peptides 29
  
  Pages : 1886-1893
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Comparison of FGF1 (aFGF) Expression between the Dorsal Motor Nucleus of Vagus and the Hypoglossal Nucleus of Rat2006
- Author(s)
  Toyoda K, Okano H, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Tooyama I
- Journal Title
  
  Acta Histochem Cytochem 39
  
  Pages : 1-7
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Comparison of FGF1(aFGF) Expression between the Dorsal Motor Nucleus of Vagus and the Hypoglossal Nucleus of Rat.2006
- Author(s)
  Toyoda K, Okano H, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Tooyama I
- Journal Title
  
  Acta Histochem Cytochem 39
  
  Pages : 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] In vitro expression of natriuretic peptides in cardiomyocytes differentiated from monkey embryonic stem cells.2005
- Author(s)
  Abdelalim EM, Takada T, Toyoda F, Omatsu-Kanbe M, Matsuura H, Tooyama I, Torii R
- Journal Title
  
  Biochem Biophys Res Commun 340
  
  Pages : 689-695
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat cholineacetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.2005
- Author(s)
  A Matsuo, JP Belier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochemistry International 46・5
  
  Pages : 423-433
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in untracellular translocation.2005
- Author(s)
  A Matsuo, JP Bellier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochemical International 46
  
  Pages : 423-433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in untracellular translocation.2005
- Author(s)
  A Matsuo, JP Bellier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochem International 46
  
  Pages : 423-433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Immunohistochemical study of TAFII250 in the rat laryngeal nervous system.2005
- Author(s)
  Okano H, Bamba H, Hisa Y, Makino S, Ando S, Tammiya G, Goto S, Kaji R, Tooyama I
- Journal Title
  
  Histochem Histopathol 20
  
  Pages : 1049-1035
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Immunohistochemical study of TAFII250 in the rat laryngeal nervous system2005
- Author(s)
  Okano H, Bamba H, Hisa Y, Makino S, Ando S, Tammiya G, Goto S, Kaji R, Tooyama I
- Journal Title
  
  Histol Histopathol 20
  
  Pages : 1029-1035
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Immunohistochemical study of TAFII250 in the rat laryngeal nervous system.2005
- Author(s)
  Okano H, Bamba H, Hisa Y, Makino S, Ando S, Tammiya G, Goto S, Kaji R, Tooyama I
- Journal Title
  
  Histology and Histopathology 20
  
  Pages : 1049-1035
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Cloning and structure of monkey cChAT from the striatum of Japanese macaque (Macaca fuscata)2005
- Author(s)
  Song Y, Kimura S, Bellier JP, Yasuhara O, Kimura H, Torii, R, Tooyama I
- Journal Title
  
  Neuroscience Research 52(Supple)
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Coexpression pattern of two variants of choline acetyltransferase and neuronal nitric oxide synthase in myenteric neurons of porcine ileum.2004
- Author(s)
  A Brehmer, F Schrodl, W Neuuber, I Tooyama, H Kimura
- Journal Title
  
  Journal of Chemical Neuroanatomy 27
  
  Pages : 33-41
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Coexpression pattern of two variants of choline acetyltransferase and neuronal nitric oxide synthase in myenteric neurons of porcine ileum.2004
- Author(s)
  A Brehmer, F Schrodl, W Neuuber, I Tooyama, H Kimura
- Journal Title
  
  J Chem Neuroanat 27
  
  Pages : 33-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Coexpression pattern of two variants of choline acetyltransferase and neuronal nitric oxide synthase in myenteric neurons of porcine ileum.2004
- Author(s)
  A Brehmer, F Schrodl, W Neuuber, I Tooyama, H Kimura
- Journal Title
  
  Journal Chemical Neuroanatomy 27
  
  Pages : 33-41
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Effective magnetic labeling of transplanted cells with HVJ-E for magnetic resonance imaging.2004
- Author(s)
  Toyoda K, Tooyama I, et al.
- Journal Title
  
  Neuroreport 15・4
  
  Pages : 589-593
- Data Source
  KAKENHI-PROJECT-16100006
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltranferase.2004
- Author(s)
  O Yasuhara, Y Aimi, A Shibano, A Matsuo, JP Bellier, M Park, I Tooyama, H Kimura
- Journal Title
  
  J Comp Neurol 472
  
  Pages : 232-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Ameliorative effects of acetyl-L-carnitine and acidic fibroblast growth factor fragment analog on brain lipid hydroperoxide level, passive avoidance learning and/or immunoreactivity for choline acetyltransferase in the medial septum in senescenceaccelerated mice.2004
- Author(s)
  K Sasaki, M Ishibashi, F Yasui, S Matsugo, I Tooyama, H Kimura, O Oomura
- Journal Title
  
  International Congress Series 1260
  
  Pages : 123-128
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.2004
- Author(s)
  A Casini, A Pinna, I Tooyama, H Kimura, G Di Chiara, TG Renda
- Journal Title
  
  European Journal of HIstochemistry 48
  
  Pages : 135-140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.2004
- Author(s)
  A Casini, A Pinna, I Tooyama, H Kimura, G Di Chiara, TG Renda
- Journal Title
  
  Eur J Histochem 48
  
  Pages : 135-140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltranferase.2004
- Author(s)
  O Yasuhara, Y Aimi, A Shibano, A Matsuo, JP Bellier, M Park, I Tooyama, H Kimura
- Journal Title
  
  Journal Comparative Neurology 472
  
  Pages : 232-245
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Amyloid Imaging Using High-Field Magnetic Resonance
- Author(s)
  Amatsubo T, Morikawa S, Taguchi H, Tooyama I
- Journal Title
  
  Magn Resn Med Sci (in press)
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Amyloid Imaging Using High-Field Magnetic Resonance
- Author(s)
  Tomone Amatsubo, Shigehiro Morikawa, Hiroyasu Taguchi, Ikuo Tooyama
- Journal Title
  
  Magn Resn Med Sci (in press)
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] 動物モデルを使った高磁場MRIによる認知症診断の可能性.
- Author(s)
  遠山育夫, 田口弘康, 雨坪知音, 森川茂廣
- Journal Title
  
  Cognition and Dementia 8(2)
  
  Pages : 121-125
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] Application of double MR imaging for analysis of multiple pathological proteins in the brain of transgenic mouse model of Alzheimer’s disease2017
- Author(s)
  kuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第44回日本脳科学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease2017
- Author(s)
  Ikuo Tooyama, Anarmaa Mendsaikhan, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第４回モンゴル神経科学会
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] ocotrienol-rich fraction derived palm oil alleviates cognitive impairment and alters metabolite profiling in AβPP/PS1 Alzheimer’s disease mice model2017
- Author(s)
  Lina Wati Durani, Hamizah Shahirah Hamezah, Nor Faeizah Ibrahim, Daijiro Yanagisawa, Muhammad Luqman Nasaruddin, Masaki Mori, Hanafi Ahmad Damanhuri, Suzana Makpol, Wan Zurinah Wan Ngah, Ikuo Tooyama
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  Alzheimer's Association International Conference 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease2017
- Author(s)
  Ikuo Tooyama, Anarmaa Mendsaikhan, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第４回モンゴル神経科学会
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Application of double MR imaging for analysis of senile plaques and Aβ oligomers in the brain of APP/PS1 double transgenic mouse model of Alzheimer’s disease2017
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  中国微小脳循環学会
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Tau imaging using fluorine-19 MRI in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Ikuo Tooyama
- Organizer
  国際アルツハイマー病学会2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] Application of double MR imaging for analysis of multiple pathological proteins in the brain of transgenic mouse model of Alzheimer’s disease.2017
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第44回日本脳科学会総会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy2017
- Author(s)
  aijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第12回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] フッ素MRIによるタウ病変のイメージング2017
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、遠山育夫
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy.2017
- Author(s)
  aijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第12回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MRIによるタウ病変のイメージング2017
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、遠山育夫
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] rain atrophy, cognitive functions and oxidative stress in aged rats.2017
- Author(s)
  Hamizah Shahirah Hamezah, Lina Wati Durani, Nor Faeizah Ibrahima, Daijiro Yanagisawa, Tomoko Kato, Akihiko Shiinoa, Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Ikuo Tooyama
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-17H03560
[Presentation] アルツハイマー病の病態解明のためのフッ素MRIによるダブルプローブイメージング法の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第11回日本分子イメージング学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Development on Shiga-Y, a potential diagnostic and therapeutic agent for Alzheimer's disease, using mouse model of dementia2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Tomoko, Kato, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi
- Organizer
  第31回SAMサテライト国際シンポシウム
- Place of Presentation
  京都
- Year and Date
  2016-07-09
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] ッ素MR画像化法によるAβオリゴマーの検出の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] pplication of double MR imaging to detect amyloid oligomers in the brain of APP/PS1 transgenic model mice.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Tomoko Kato, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント、カナダ
- Year and Date
  2016-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] A novel curcumin derivative, f-methyl-curcumin-1 (fmec1), is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Tooyama, D. Yanagisawa, N. F. Ibrahim, H. Taguchi
- Organizer
  14th Meeting of Asia-Pacific Society for Neurochemistry
- Place of Presentation
  クアラルンプール、マレーシア
- Year and Date
  2016-07-27
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] -methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Tomoko Kato, Shieghiro Morikawa
- Organizer
  第57回日本神経学会総
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Application of double MR imaging to detect amyloid oligomers in the brain of APP/PS1 transgenic model mice2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Tomoko Kato, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント、カナダ
- Year and Date
  2016-07-22
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] アルツハイマー病の病態解明のためのフッ素MRIによるダブルプローブイメージング法の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第11回日本分子イメージング学
- Place of Presentation
  神戸
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MR画像化法によるAβオリゴマーの検出の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫:
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Tomoko Kato, Shieghiro Morikawa
- Organizer
  第57回日本神経学会総会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, and Ikuo Tooyama
- Organizer
  アルツハイマー病協会国際会議(AAIC)2015
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Styrylbenzoxazole and curcumin derivatives that have preferred features of a fluorine-19 MRI probe for amyloid imaging.2015
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikaw
- Organizer
  国際分子イメージング学会2015
- Place of Presentation
  米国ホノルル市
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, and Ikuo Tooyama
- Organizer
  アルツハイマー協会国際会議(AAIC）2015
- Place of Presentation
  米国ワシントンＤＣ
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Styrylbenzoxazole and curcumin derivatives that have preferred features of a fluorine-19 MRI probe for amyloid imaging.2015
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  国際分子イメージング学会2015
- Place of Presentation
  米国ホノルル市
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Effect of novel curcumin derivatives on amyloid aggregation and the cell toxicity2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Effect of novel curcumin derivatives on amyloid aggregation and the cell toxicity.2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] クルクミン誘導体によるアミロイドβ凝集抑制作用の解析2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Yanagisawa D, Ibrahim NF, Durani LW, Hamezah HS, Taguchi H, Morikawa S, Hirao K, Shirai N, Tooyama I.
- Organizer
  Alzheimer’s Association International Conference on Alzheimer’s Disease 2015,
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] Effect of novel curcumin derivatives on amyloid aggregation and the cell toxicity.2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Targeting Antioxidant Pathways in Neurodegeneration2015
- Author(s)
  Tooyama I
- Organizer
  第１回抗酸化物質ｓと細胞変性に関する国際会議
- Place of Presentation
  マレーシア国クアラルンプール市
- Year and Date
  2015-06-03
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, and Ikuo Tooyama
- Organizer
  アルツハイマー病協会国際会議(AAIC)2015
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Styrylbenzoxazole and curcumin derivatives that have preferred features of a fluorine-19 MRI probe for amyloid imaging.2015
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  国際分子イメージング学会2015
- Place of Presentation
  米国ホノルル市
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] argeting Antioxidant Pathways in Neurodegeneration2015
- Author(s)
  Ikuo Tooyama:
- Organizer
  第１回抗酸化物質ｓと細胞変性に関する国際会議
- Place of Presentation
  マレーシア国クアラルンプール市
- Year and Date
  2015-06-03
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] クルクミン誘導体によるAβ凝集抑制効果とAβによる細胞障害軽減効果の解析2014
- Author(s)
  柳沢大治郎、遠山育夫、Ibrahim, Nor Faeizah、田口弘康
- Organizer
  第11回サプリメント研究会
- Place of Presentation
  東京、日本
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイド斑の検出（その2）2013
- Author(s)
  Yanagisawa D, Morikawa S, Taguchi H, Shiino A, Inubushi T, Ibrahim NF, Tooyama I
- Organizer
  第36回日本神経科学会学術大会（Neuro2013）
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病遺伝子改変マウスの鼻粘膜Aβ42量は脳内Aβ42の蓄積量に比例する2013
- Author(s)
  遠山育夫、亀島直子、南條俊文、福原崇臣、柳沢大治郎
- Organizer
  第54回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-24111522
[Presentation] Preferable features of Fluorine-19 MRI probe required for amyloid detection in the brain2013
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Inubushi T, Ibrahim NF, Hirao K, Shirai N, Sogabe T, Tooyama I
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PUBLICLY-24111522
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイド斑の検出（その2）2013
- Author(s)
  柳沢大治郎、森川茂廣、田口弘康、椎野顯彦、犬伏俊郎、Nor Faeizah Ibrahim、遠山育夫
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-24111522
[Presentation] Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.2013
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Inubushi T, Ibrahim NF, Hirao K, Shirai N, Sogabe T, Tooyama I
- Organizer
  第15回国際アルツハイマー病会議 (AAIC2013)
- Place of Presentation
  米国ボストン
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] A novel 19F MRI probe for detecting amyloid deposition in Alzheimer’s disease2012
- Author(s)
  Ikuo Tooyama
- Organizer
  第５回ハルピン国際脳神経外科学会
- Place of Presentation
  中国ハルピン市
- Year and Date
  2012-07-13
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111522
[Presentation] クルクミン骨格をもつ高磁場MRI用アミロイドイメージング試薬の検討2012
- Author(s)
  遠山育夫
- Organizer
  第53回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Aβ deposition in the nasal cavity in the brain of a transgenic mouse model of Alzheimer's disease2012
- Author(s)
  Naoko Kameshima, Toshifumi Nanjou, Takaomi Fukuhara, Ikuo Tooyama
- Organizer
  アルツハイマー学会国際会議2012
- Place of Presentation
  カナダ、バンクーバー
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] A novel 19F MRI probe for detecting amyloid plaques in Alzheiemr's disease2012
- Author(s)
  Tooyama I
- Organizer
  The 5th Harbin International Neurosugery Conference
- Place of Presentation
  中国、ハルビン
- Invited
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Development of a simple and sensitive method for measurements of A,and its application to measure Aβ contents in human nasalsmea2012
- Author(s)
  Nanjo T, Kameshima N, Fukuhara T, Sogabe S, Tooyama I
- Organizer
  第14回国際アルツハイマー病会議(ICAD2012)
- Place of Presentation
  カナダバンクーバー市
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] A novel 19F MRI probe for detecting amyloid deposition in Alzheimer’s disease2012
- Author(s)
  遠山育夫
- Organizer
  The 5th Harbin International Neurosurgical Conference
- Place of Presentation
  中国、ハルピン市
- Invited
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin binding activity to B-amyloid oligomer2011
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin binding activity to ss-amyloid oligomer2011
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo, T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病診断のための新規MR造影剤の開発2011
- Author(s)
  遠山育夫
- Organizer
  平成24年度神戸医師会学術講演会
- Place of Presentation
  神戸市(特別講演)(招待講演)
- Year and Date
  2011-04-09
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin derivatives for amyloid detection using 19F magnetic resonance imaging2011
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Development of highy accurate mesurements of Aβ using formic acid2011
- Author(s)
  Nanjo T, Tooyama I, Kameshima N, Fukuhara T
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイドの検出2011
- Author(s)
  柳沢大治郎、森川茂廣、田口弘康、椎野顕彦、犬伏俊郎、遠山育夫
- Organizer
  第34回日本神経科学会学術大会(Neuro2011)
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Aβ40 deposition in the nasal cavity of a transgenic mouse model of Alzheimer's disease2011
- Author(s)
  Kameshima N, Tooyama I, Fukuhara T, Kouge M, Nanjo T
- Organizer
  第13回国際アルツハイマー病会議 (ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] アルツハイマー病とクルクミン2011
- Author(s)
  遠山育夫
- Organizer
  第5回認知症サプリメント研究会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] アルツハイマー病の新しい診断基準とバイオマーカー研究について2011
- Author(s)
  遠山育夫
- Organizer
  湖北認知症セミナー(招待講演)
- Place of Presentation
  長浜
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] クルクミンのケトエノール互変異性とアミロイド親和性を利用したアルツハイマー病診断薬の検討2011
- Author(s)
  遠山育夫、柳沢大治郎、田口弘康
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病とクルクミン2011
- Author(s)
  遠山育夫
- Organizer
  第5回認知症サプリメント研究会
- Place of Presentation
  東京
- Year and Date
  2011-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病とクルクミン2011
- Author(s)
  遠山育夫
- Organizer
  第5回認知症サプリメント研究会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-23650192
[Presentation] パーキンソン病モデルラットにおけるfluoro-dopaのMR画像2010
- Author(s)
  遠山育夫、小田恵輔、柳沢大治郎、高田和幸、北村佳久、谷口隆之、森川茂廣、犬伏俊郎
- Organizer
  第5回日本分子イメージング学会総会・学術集会
- Place of Presentation
  大津市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] パーキンソン病モデルラットにおける fluoro-dopa のMR画像2010
- Author(s)
  遠山育夫, 小田恵輔, 柳沢大治郎, 高田和幸, 北村佳久, 谷口隆之, 森川茂廣, 犬伏俊郎
- Organizer
  第5回分子イメージング学会
- Place of Presentation
  大津市
- Year and Date
  2010-05-23
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Binding form of curcumin derivatives to B-amyloid aggregates2010
- Author(s)
  Ynagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第12回国際アルツハイマー病会議(ICAD2010)
- Place of Presentation
  米国ホノルル市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Binding form of curcumin derivatives to β-amyloid aggregates.2010
- Author(s)
  Yanagisawa D, Tooyama I, ほか
- Organizer
  第12回国際アルツハイマー病会議(ICAD2010)
- Place of Presentation
  米国ホノルル市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Interaction of the brain tissues with trifluoromethoxy-benzylated ligands for amyloid detection using 19F magnetic resonance imaging2008
- Author(s)
  Tomone Amatsubo, Shigehiro Morikawa, Keiko Matsuda, Toshiro Inubushi, Makoto Urushitani, Hiroyasu Taguchi, Nobuaki Shirai, Koichi Hirao, Masanari Kato, Kyuya Morino, Hirohiko Kimura, Ichiro Nakano, Chikako Yoshida, Takashi Okada, Mitsuo Sano, Ikuo Tooyama
- Organizer
  第10回国際アルツハイマー病会議(ICAD2008)
- Place of Presentation
  米国シカゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Trifluoromethoxy-benzylated化合物と脳組織の相互作用による19Fシグナル強度の変化2008
- Author(s)
  雨坪知音、森川茂廣、松田敬子、田口弘康、白井伸明、平尾浩一、遠山育夫
- Organizer
  第3回日本分子イメージング学会総会・学術集会
- Place of Presentation
  さいたま市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Bezoxazol derivatives containing trifluoromethoxy-benzyl amino group for amyloid detection in APP transgenic mice using ^<19>F magnetic resonance imaging2008
- Author(s)
  H Taguchi, T Amatsubo, S Morikawa, K Matsuda, N Shirai, K Hirao, M Kato, HMorino, H Kimura, I Nakano, C Yoshida, T Okada, MSano, I Tooyama
- Organizer
  第11回国際アルツハイマー病会議(ICAD2008)
- Place of Presentation
  米国シカゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] 統合失調症病態モデルとしての子宮内仮死経験ラットの検討.2007
- Author(s)
  和久田智靖, 松崎秀夫, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] アルツハイマー病の細胞治療法とMR画像法による投与細胞のin vivo追跡法2007
- Author(s)
  遠山育夫
- Organizer
  第34回日本脳科学会
- Place of Presentation
  出雲市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Immunohistochemical Mapping of NPR-A in the Brainstem of Macaca Fascicularis2007
- Author(s)
  E. M. Abdelalim, A. K. Osman, T. Takada, R. Torii, and I. Tooyama
- Organizer
  第30回日本神経科学会議
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18659110
[Presentation] 脳内神経再生の修飾による統合失調症の新しい治療法開発の試み.2007
- Author(s)
  松崎秀夫, 和久田智靖, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] 統合失調症病態モデルとしての子宮内仮死経験ラットの検討2007
- Author(s)
  和久田智靖, 松崎秀夫, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] MR tracking of transplanted neural cells using fluorinated poly-L-lysine-CF32007
- Author(s)
  Makoto Urushitani, Chiaki Masuda, Hiroyasu Taguchi, Shigehiro Morikawa, Toshiro Inubushi, Nobuaki Shirai, Koichi Hirao, Ikuo Tooyama
- Organizer
  第37回北米神経科学会議(Neuro2007)
- Place of Presentation
  米国サンディエゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] アルツハイマー病の細胞治療法とMR画像法による投与細胞のin vivo追跡法.2007
- Author(s)
  遠山育夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] 脳内神経再生の修飾による統合失調症の新しい治療法開発の試み2007
- Author(s)
  松崎秀夫, 和久田智靖, 土手基慶, 岩田泰秀, 鈴木勝昭, 遠山正彌, 森則夫
- Organizer
  日本脳科学会第34回総会
- Place of Presentation
  島根県出雲市
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19209039
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim NF, Durani L, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I
- Organizer
  北米神経科学会議（Neuro2014)
- Place of Presentation
  ワシントンDC、米国
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Voxel Based Morphometry (VBM)評価方法によるアルツハイマー病の早期診断
- Author(s)
  古賀恒行、遠山育夫、森川茂廣、谷垣健二、椎野顯彦
- Organizer
  第42回日本磁気共鳴医学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-09-18 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] A novel 19F MRI probe for detecting amyloid deposition in Alzheimer’s disease.
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Akihiko Shiino, Toshiro Inubushi, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  アルツハイマー病国際学会（AAIC2014）
- Place of Presentation
  デンマークコペンハーゲン市
- Year and Date
  2014-07-14 – 2014-07-17
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Induction of mitochondrial ferritin by proinflammatory cytokines is mediated via NF-kappaB signaling pathway and involves in neuroprotection in Alzheimer’s disease.
- Author(s)
  H. YANG, H. GUAN, M. YANG, Z. LIU, S. ZHAO, S. TAKEUCHI, D. YANAGISAWA, S. R. VINCENT, I. TOOYAMA
- Organizer
  北米神経科学会（Neuroscience2014）
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] 高磁場MR 装置を利用したフッ素MRI アミロイドイメージングのためのstyrylbenzoxazole 誘導体の開発
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、椎野顯彦、犬伏俊郎、遠山育夫
- Organizer
  第9回日本分子イメージング学会学術集会
- Place of Presentation
  豊中市
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] 高磁場MR装置を利用したフッ素MRIアミロイドイメージングのためのstyrylbenzoxazole誘導体の開発
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、椎野顯彦、犬伏俊郎、遠山育夫
- Organizer
  第9回分子イメージング学会
- Place of Presentation
  大阪市豊中市
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Effect of novel curcumin derivatives on amyloid pathology in APP/PS1 mice
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第３７回日本神経科学大会(Neuroscience 2014)
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-11 – 2014-09-15
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice.
- Author(s)
  D. YANAGISAWA, H. TAGUCHI, N. IBRAHIM, L. DURANI1, S. MORIKAWA, K. HIRAO, N.　SHIRAI, T. SOGABE, I. TOOYAMA
- Organizer
  北米神経科学会（Neuroscience2014）
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Fluorine-19 MRI probe for detecting amyloid deposition in Alzheimer’s disease
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Shigehiro Morikawa, Akihiko Shiino, Koichi Hirao, Nobuaki Shirai,Takayuki Sogabe
- Organizer
  第３７回日本神経科学大会(Neuroscience 2014)
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-11 – 2014-09-15
- Data Source
  KAKENHI-PUBLICLY-26111709
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice.
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim N, Durani L, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I.
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, D. C., United States of America
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] Effect of novel curcumin derivatives on amyloid pathology in APP/PS1 mice
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第37回日本神経科学学会学術大会
- Place of Presentation
  横浜市、日本
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26290022

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Tooyama Ikuo 遠山 育夫

TOOYAMA Ikuo 遠山 育夫

Research Projects

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Co-Researchers

Simultaneous analysis of A&#223; oligomers, A&#223; fibrils and phosphrylated tau protein using fluroine-MRIPrincipal InvestigatorOngoing

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神経難病診断のためのMR画像用試薬の開発Ongoing

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ケミカルシフトの違いを利用したフッ素MR画像による複数の脳内異常蛋白の同時解析Principal Investigator

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Development of novel diagnostic and therapeutic methods on Alzheimer's disease by targeting amyloid oligomersPrincipal Investigator

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Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.Principal Investigator

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フッ素ＭＲ画像法と光画像法によるアミロイドオリゴマーのｉｎ ｖｉｖｏ病態解析Principal Investigator

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Review Section

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Development of hemodiagnostic methods for Alzheimer's disease using curcuimin derivativesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Tooyama Ikuo 遠山育夫

TOOYAMA Ikuo 遠山育夫

Simultaneous analysis of Aß oligomers, Aß fibrils and phosphrylated tau protein using fluroine-MRIPrincipal InvestigatorOngoing

フッ素ＭＲ画像法と光画像法によるアミロイドオリゴマーのｉｎ　ｖｉｖｏ病態解析Principal Investigator