SHIMIZU Takeshi 清水猛史

Researcher Number	00206202
Other IDs
Affiliation (Current)	2023: 滋賀医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2008 – 2022: Shiga University of Medical Science, 医学部, 教授 2004: Shiga University of Medical Science, Department of Otorhinolaryngology, Professor, 医学部, 教授 2003: 三重大学, 医学部附属病院, 助教授 2001: Mie Univ. Faculty of Medicine associate Prof., 医学部・附属病院, 助教授 1996 – 2000: 三重大学, 医学部・附属病院, 講師 1993 – 1995: 三重大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology / Otorhinolaryngology
Keywords	Principal Investigator 鼻粘膜 / IL-8 / 慢性副鼻腔炎 / 好酸球 / サイトカイン / 粘液 / 杯細胞化生 / 好酸球性副鼻腔炎 / 鼻茸 / アレルギー性鼻炎 … More / 上皮細胞 / 組織リモデリング / ＥＧＦ受容体 / 鼻茸形成 / ＭＵＣ５ＡＣ / ムチン / TGF-alpha / amphiregulin / モノクローナル抗体 / 杯細胞 / 分泌 / Nasal epithelium / mucus / LPS / スギ・ヒノキ花粉症 / 舌下免疫療法 / 抗原特異的免疫グロブリン / 細胞増殖 / 粘液糖蛋白 / エンドトキシン / 鼻科学 / リポキシン / リポキシン受容体 / VEGF / プロスタグランディンE2 / TNFα / 鼻副鼻腔炎 / 粘液産生 / MUC5AC / 気道上皮細胞 / EGFR / ADAM / ＥＧＦ受容体阻害薬 / ラット鼻粘膜 / 鼻粘膜上皮細胞 / 線維芽細胞 / ＥＧF受容体阻害薬 / ＩＬ－８ / ＬＰＳ / ＴＮＦ－alpha / 鼻汁 / 腺細胞 / ELISA / Monoclonal antibody / Chronic sinusitis / Nasal allergy / Goblet cell / Mucus / Nasal gland / Mucus secretion / 分泌細胞 / 細胞培養 / マクロライド剤 / マクロライド / 細胞分化 / 線毛細胞 / secretion / goblet cell / secretory cell / cell culture / nasal epithelium / monoclonal antibody / MUC gene / プロスタグランディンE_2 / アレルギー / 好中球 / Prostaplandin E_2 / Allergy / Neutrophil / Eosinophil / 制御性B細胞 / 制御性T細胞 / IL-35 / メモリーT細胞 / 抗原特異的IgE抗体 / スギ花粉症 / ヒノキ花粉症 / 制御性濾胞性T細胞 / 抗原特異的IgG4抗体 / アポトーシス / IL-10 / 特異的IgG4 / 網羅的RNA解析 / スギ花粉舌下免疫療法 / 制御性Ｔ細胞 / 特異的免疫グロブリン / ダニアレルギー性鼻炎 / 末梢血単核球サブセット … More Except Principal Investigator mucus / 好酸球性副鼻腔炎 / 気道液 / 慢性副鼻腔炎 / 動物モデル / chronic sinusitis / animal model / サイトカイン / 上皮細胞 / アレルギー / 抗原 / 気道上皮細胞 / アレルゲン / プロテアーゼ / IL-33 / IL-25 / TSLP / アルツハイマー病 / 早期診断 / ヒト鼻腔 / アミロイドβ / タウ蛋白 / 嗅粘膜 / インフルエンザウイルス / マクロライド / クラリスロマイシン / カニクイザル / 気道 / 粘液産生 / 粘液腺 / 漿液腺 / 杯細胞 / 3D培養 / 好中球 / 粘膜産生 / 奨液腺 / 奬液腺 / レオロジー / 気通液 / 粘液腔 / airway / mucus production / serous cell / mucous cell / goblet cell / 3-D culture / neutrophil / 腺細胞 / 増殖 / 分化 / 過形成 / 増殖因子 / 腺の分化 / 腺の増殖 / 粘液産生モデル / 粘性、弾性 / 粘性,弾性 / 粘性・弾性 / gland / proliferation / differentiation / hyperplasia / growth factor / アレルギー性鼻炎 / 鼻茸 / リモデリング / 粘膜下腺 / 粘液 / 細胞外マトリックス / 鼻 / 副鼻腔 / ムチン遺伝子 / 気道分泌 / allergic rhinitis / nasal polyposis / remodeling / submucosal gland / extracellular matrix / 血液凝固因子 / 鼻茸線維芽細胞 / フィブロネクチン / TGF-beta / eotaxin / RANTES / EGF受容体インヒビター / 線維芽細胞 / トロンビン / 活性化第１０因子 / GM-CSF / fibronectin / PARs / 耳鼻咽喉科学 / 好酸球性鼻副鼻腔炎 / 凝固系因子 Less

New mechanisms of sublingual immunotherapy for the treatment of allergic rhinitisPrincipal Investigator
- Principal Investigator
  
  清水猛史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shiga University of Medical Science
A mechanism of sublingual immunotherapy with Japanese cedar extract for the treatment of patients with Japanese cedar and cypress pollinosisPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKESHI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shiga University of Medical Science
Elucidation of the pathophysiology of eosinophilic chronic rhinosinusitis focusing on the action of coagulation factors on fibroblasts and eosinophils
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Tissue remodering of eosinophilic chronic rhinosinusitisPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKESHI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Efficacy of clarithromycin against avian influenza A virus
- Principal Investigator
  
  ARIKATA MASAHIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodelingPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKESHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
The role of epithelial derived cytokines (TSLP, IL-25,IL-33) in the airway diseases
- Principal Investigator
  
  KOUZAKI Hideaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Role of lipoxin as an inhibitory mediator in upper airway inflammationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Remodeling of the nose and the paranasal sinuses under diseased conditions
- Principal Investigator
  
  MAJIMA Yuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Prostaglandin E_2 inhibits airway inflammationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
  Mie University
MECHANISMS OF PROLIFERATION AND DIFFERENTIATION OF AIRWAY GLANDS
- Principal Investigator
  
  MAJIMA Yuichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Secretory cell differentiation and mucus secretion in cultures of human nasal epithelial cells.Principal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
The study of mucus hypersecretion in respiratory glands.
- Principal Investigator
  
  MAJIMA Yuichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Monoclonal antibodies as probes for studying human nasal secretionsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takeshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
鼻粘膜上皮の杯細胞化生に関する研究-エンドトキシンを利用した動物モデル作成と細胞特異的分化マーカーと免疫組織化学法を用いた病態の解明-Principal Investigator
- Principal Investigator
  
  清水猛史
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University

[Book] Recent Advances in Rhinosinusitis and Nasal Polyposis2015
- Author(s)
  Shimizu T, Shimzu S, Ogawa T, Takezawa K, Kouzaki H
- Publisher
  Kugler Publications, Amsterdam
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Anti-inflammatory roles of interleukin-35 in the pathogenesis of Japanese cedar pollinosis2021
- Author(s)
  Kouzaki Hideaki、Arai Yukihiro、Nakamura Keigo、Murao Takuya、Tojima Ichiro、Shimizu Shino、Yuta Atsushi、Shimizu Takeshi
- Journal Title
  
  Asia Pacific Allergy
  
  Volume: 11 Pages: 1-10
- DOI
  10.5415/apallergy.2021.11.e34
- NAID
  120007161278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03802
[Journal Article] Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in patients with combined Japanese cedar and Japanese cypress pollinosis2020
- Author(s)
  Kikuoka Hirotaka、Kouzaki Hideaki、Matsumoto Koji、Arai Hiroyuki、Yamamoto Sayuri、Tojima Ichiro、Shimizu Shino、Miyashita Hiromi、Ogawa Yukiko、Osada Toshihiro、Okano Mitsuhiro、Yuta Atsushi、Shimizu Takeshi
- Journal Title
  
  Clinical Immunology
  
  Volume: 210 Pages: 108310-108310
- DOI
  10.1016/j.clim.2019.108310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16908, KAKENHI-PROJECT-19H03802, KAKENHI-PROJECT-18K16883
[Journal Article] Dynamic change of anti‐inflammatory cytokine IL‐35 in allergen immune therapy for Japanese cedar pollinosis2019
- Author(s)
  Kouzaki Hideaki、Arikata Masahiko、Koji Matsumoto、Arai Hiroyuki、Yamamoto Sayuri、Kikuoka Hirotaka、Fujimoto Noriki、Ogawa Yukiko、Yuta Atsushi、Shimizu Takeshi
- Journal Title
  
  Allergy
  
  Volume: 00 Pages: 1-3
- DOI
  10.1111/all.14124
- NAID
  120006777345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03802
[Journal Article] The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways2018
- Author(s)
  Shimizu Shino, Takezawa-Yasuoka Kumiko, Ogawa Takao, Tojima Ichiro, Kouzaki Hideaki, Shimizu Takeshi
- Journal Title
  
  Clinical Immunology
  
  Volume: 188 Pages: 1-6
- DOI
  10.1016/j.clim.2017.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20200, KAKENHI-PROJECT-16K11212
[Journal Article] Thrombin and activated coagulation factor X stimulate the release of cytokines and fibronectin from nasal polyp fibroblasts protease-activated receptors2017
- Author(s)
  Shimizu S, Tojima I, Takezawa K, Matsumoto K, Kouzaki H, Shimizu T
- Journal Title
  
  American Journal of Rhinology and Allergy
  
  Volume: 31 Pages: 13-18
- DOI
  10.2500/ajra.2017.31.4400
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462581, KAKENHI-PROJECT-16K11212, KAKENHI-PROJECT-15K20200
[Journal Article] 難治性上気道炎症に対する新たな局所治療薬としてのEpidermal growth factor(EGF)受容体阻害薬の可能性2016
- Author(s)
  竹澤公美子、小河孝夫、清水志乃、清水猛史
- Journal Title
  
  耳鼻免疫アレルギー
  
  Volume: ３４ Pages: 1-7
- NAID
  130005141309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion in airway epithelium2016
- Author(s)
  Takezawa K, Ogawa T, Shimizu S, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: ３０ Pages: 1-6
- DOI
  10.2500/ajra.2016.30.4263
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] 難治性上気道炎症に対する新たな局所治療薬としてのEpidermal growth factor (EGF)受容体阻害薬の可能性2016
- Author(s)
  竹澤公美子、小河孝夫、清水志乃、清水猛史
- Journal Title
  
  耳鼻免疫アレルギー
  
  Volume: ３４ Pages: 1-7
- NAID
  130005141309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhinosinusitis2016
- Author(s)
  Shimizu T, Shimizu S, Ogawa T, Takezawa K, Kouzaki H
- Journal Title
  
  Recent advances in thinosinusitis and nasal polyposis
  
  Volume: 0 Pages: 111-116
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in tissue remodeling2014
- Author(s)
  Shimizu S, Kouzaki H, Ogawa T, Takezaka K, Tojima I, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 28 Pages: 103-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling.2014
- Author(s)
  Shimizu S, Kouzaki H, Ogawa T, Takezawa K, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 28 Pages: 103-109
- DOI
  10.2500/ajra.2014.28.4018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23592509, KAKENHI-PROJECT-24791770, KAKENHI-PROJECT-26462581
[Journal Article] Transcription of interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells.2013
- Author(s)
  Kouzaki H, Tojima I, Kita H, Shimizu T
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: in press
- DOI
  10.1165/rcmb.2012-0304oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791594
[Journal Article] 好酸球性副鼻腔炎の疑問-ニカワ様鼻汁の本態は何か?好酸球は何をしているのか?2012
- Author(s)
  清水猛史
- Journal Title
  
  耳鼻臨床
  
  Volume: 105 Pages: 803-812
- NAID
  10031012193
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] 免疫アレルギー学の最前線 IL-25 誘導によるアレルギー性炎症2012
- Author(s)
  神前英明、清水猛史
- Journal Title
  
  耳鼻咽喉科免疫アレルギー
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791594
[Journal Article] 好酸球性副鼻腔炎の疑問－ニカワ様鼻汁の本態は何か？好酸球は何をしているのか？2012
- Author(s)
  清水猛史
- Journal Title
  
  耳鼻臨床
  
  Volume: 105 Pages: 803-812
- NAID
  10031012193
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] Interleukin-25 induces allergic inflammation2012
- Author(s)
  神前英明、清水猛史
- Journal Title
  
  Journal of Japan Society of Immunology & Allergology in Otolaryngology
  
  Volume: 30 Issue: 3 Pages: 237-242
- DOI
  10.5648/jjiao.30.237
- NAID
  10031163497
- ISSN
  0913-0691, 2185-5900
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791594
[Journal Article] 上皮細胞から放出される IL-33 とその役割2011
- Author(s)
  神前英明, 紀太博仁, 清水猛史
- Journal Title
  
  日本鼻科学会会誌
- NAID
  130004546071
- URL
  http://dx.doi.org/10.7248/jjrhi.50.46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791594
[Journal Article] Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats.2009
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Journal Title
  
  Ann Otol Rhinol Laryngol 118
  
  Pages: 536-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats2009
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Journal Title
  
  Ann Otol Rhinol Laryngol 118
  
  Pages: 536-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] EP4 agonist inhibits lipopolysaccharide-induced mucus secretion in airway epithelial cells.2008
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Journal Title
  
  Ann Otol Rhinol Laryngol 117
  
  Pages: 51-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] EP4 agonist inhibits lipopolysaccharide-induced mucus secretion in airway epithelial cells2008
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Journal Title
  
  Ann Otol Rhinol Laryngol 117
  
  Pages: 51-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells.2003
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Am J Respir Grit Med 168
  
  Pages: 581-587
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390516
[Journal Article] A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium of sensitized rats.2003
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  J Allergy Clin Immunol 112
  
  Pages: 119-125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390516
[Journal Article] In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells.2003
- Author(s)
  Shimizu T, et al.
- Journal Title
  
  Am J Respir Crit Med 168
  
  Pages: 581-587
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390516
[Journal Article] 上気道炎症におけるリポキシンの役割
- Author(s)
  清水志乃、星恵理子、神前英明, 他
- Journal Title
  
  耳鼻免疫アレルギー(JJIAO)
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-20591999
[Journal Article] 上気道炎症におけるリポキシンの役割
- Author(s)
  清水志乃、星恵理子、神前英明、清水猛史
- Journal Title
  
  耳鼻免疫アレルギー(JJIAO) 印刷中
- Data Source
  KAKENHI-PROJECT-20591999
[Patent] 採取パーツと採取パーツを備える生体組織採取具2014
- Inventor(s)
  南條俊文、福原崇臣、濱中健一、遠山育夫、清水志乃
- Industrial Property Rights Holder
  パナソニックヘルスケア株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-011126
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462663
[Patent] 生体組織採取器具2014
- Inventor(s)
  森分優太、篠原紀行、南條俊文、濱中健一、遠山育夫、清水志乃等
- Industrial Property Rights Holder
  パナソニックヘルスケア株式会社
- Industrial Property Rights Type
  意匠
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462663
[Presentation] アレルゲン免疫療法の進歩2021
- Author(s)
  神前英明、湯田厚司、清水猛史
- Organizer
  第122回日本耳鼻咽喉科頭頸部外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] 上気道炎症の業態とその制御-臨床における疑問とその解明2021
- Author(s)
  清水猛史
- Organizer
  第60回日本鼻科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] アレルゲン免疫療法の進歩2021
- Author(s)
  神前英明、湯田厚司、清水猛史
- Organizer
  第122回日本耳鼻咽喉科学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ花粉舌下免疫療法によるMemory CD4+T細胞のアポトーシス誘導2021
- Author(s)
  新井宏幸、神前英明、中村圭吾、村尾拓哉、湯田厚司、清水猛史
- Organizer
  第122回日本耳鼻咽喉科学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] アレルゲン免疫療法のメカニズム解明へのアプローチ2021
- Author(s)
  神前英明、菊岡弘高、新井、湯田厚司、清水猛史
- Organizer
  第1回耳鼻咽喉科免疫アレルギー感染症学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ花粉舌下免疫療法によるメモリーCD4+T細胞のアポトーシス誘導2021
- Author(s)
  新井宏幸、神前英明、中村圭吾、村尾拓哉、湯田厚司、清水猛史
- Organizer
  第122回日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ花粉舌下免疫療法における制御性B細胞によるメモリーTh2細胞、Tfh2細胞のアポトーシス誘導2021
- Author(s)
  新井宏幸、神前英明、村尾拓哉、中村圭吾、湯田厚司、清水猛史
- Organizer
  第60回日本鼻科学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] Sublingual immunotherapy with Japanese cedar pollen extract induces apoptosis of memory CD4+ T cells2020
- Author(s)
  Hiroyuki Arai, Hideaki Kouzaki, Atsushi Yuta, Takeshi Shimizu
- Organizer
  JSA/WAO Joint Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ花粉舌下免疫療法におけるメモリーCD4+T細胞のアポトーシス2020
- Author(s)
  新井宏幸、神前英明、湯田厚司、清水猛史
- Organizer
  第38回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] Future prediction of Japanese cedar (JC) and Japanese cypress pollen scattering and the immunological effects of sublingual immunotherapy with JC pollen extracts for the treatment of combined JC and Japanese cypress pollinosis2019
- Author(s)
  Takeshi Shimizu
- Organizer
  5th Rhinology Research Forun in Asia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ・ヒノキ花粉症患者におけるスギ花粉症舌下免疫療法のヒノキ花粉症に対する免疫学的作用2019
- Author(s)
  菊岡弘高、神前英明、松本晃治、戸嶋一郎、清水志乃、長田年弘、岡野光博、湯田厚司、清水猛史
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] スギ・ヒノキ花粉症患者におけるスギ花粉症舌下免疫療法のヒノキ花粉症に対する免疫学的作用2019
- Author(s)
  菊岡弘高、神前英明、松本晃治、戸嶋一郎、清水志乃、長田年弘、岡野光博、湯田厚司、清水猛史
- Organizer
  第1回日本アレルギー学会地方会近畿支部学術講演会
- Data Source
  KAKENHI-PROJECT-19H03802
[Presentation] 上気道炎症における組織リモデリングとその制御2018
- Author(s)
  清水志乃
- Organizer
  第67回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of eosinophils in pathophysiology of eosinophilic CRS2017
- Author(s)
  Takeshi Shimizu
- Organizer
  The 9th annual meeting of the Thai Rhinologic Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of infiltrating eosinophils in pathophysiology of CRS2017
- Author(s)
  Takeshi Shimizu
- Organizer
  Rhinology World Congress Hong Kong
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion and neutrophil infiltration in airway epithelium2016
- Author(s)
  Takezawa K, Ogawa T, Shimizu S, ShimizuT
- Organizer
  35th Congress of the International Society of Inflammation & Allergy of the Nose
- Place of Presentation
  Stockholm
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] 上気道炎症の組織リモデリングにおける凝固系因子と好酸球の役割2016
- Author(s)
  清水志乃
- Organizer
  日本鼻科学会
- Place of Presentation
  宇都宮市
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of EGFR in upperairway inflammation2016
- Author(s)
  Shimizu T
- Organizer
  2nd Rhinology Research Forum in Asia
- Place of Presentation
  Singapore
- Year and Date
  2016-12-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Eosinophil-epithelial cell interaactions stimulate the production of MUC5AC mucin and profibrotic cytokines through the transactivation of epidermal growth factor receptor in airway epithelial cells2015
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  16th World Congress of Rhinology
- Place of Presentation
  San Paulo, Brazil
- Year and Date
  2015-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2015
- Author(s)
  Shimizu T
- Organizer
  17th Asian Research Symposium in Rhinology
- Place of Presentation
  Beijing, China
- Year and Date
  2015-04-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Our research interests and pathogenesis of eosinophilic chronic rhinosinusitis2015
- Author(s)
  Shimizu T
- Organizer
  11th Research Symposium on Human Natural Defense System
- Place of Presentation
  Seoul, Korea
- Year and Date
  2015-10-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Interaction between coagulation and upper airway inflammation2015
- Author(s)
  Shimizu T
- Organizer
  13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2015-12-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Tsissue remodeling of eosinophil-associated chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  Kyung Hee International Rhinologic Symposium 2013
- Place of Presentation
  Seoul, South Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhunosinusitis2013
- Author(s)
  Shimizu T, Shimizu S, Ogawa T, Takezawa K, Kouzaki H
- Organizer
  VIIInternational Syumposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
- Place of Presentation
  Matsue
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Transcription of Interleukin-25 and Extracellular Release of the Protein Is Regulated by Allergen Proteases in Airway Epithelial Cells2013
- Author(s)
  Kouzaki H, Tojima I, Kita H, Shimizu T
- Organizer
  AAAAI 2013 Annual Meeting
- Place of Presentation
  USA
- Year and Date
  2013-02-25
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  The 12th Taiwan-Japan conference on Otolaryngology-Head and Neck Surgery
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  The 12^<th> Taiwan-Japan Conference on Otolarynggology-Head and Neck Surgery
- Place of Presentation
  Taipei
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  16th Asian Research Symposium in Rhinology
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Symposium, Up-to-date Research in CRS : Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  16^<th> Asian Research Symposium in Rhinology
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  VII International symposium on recent advances in rhinosinusitis and nasal polyposis
- Place of Presentation
  Matsue, Shimane
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 粘液・サイトカイニン分泌における好酸球と上皮細胞の交互作用2012
- Author(s)
  清水志乃、清水猛史
- Organizer
  アレルギー・好酸球研究会2012
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] プロテアーゼは気道上皮細胞において PAR-2 受容体を介して IL-25 産生を誘導する2012
- Author(s)
  神前英明、戸嶋一郎、紀太博仁、清水猛史
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  滋賀
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 粘液・サイトカイン分泌における好酸球と上皮細胞の相互作用2012
- Author(s)
  清水志乃、清水猛史
- Organizer
  アレルギー・好酸球研究会2012
- Place of Presentation
  東京
- Year and Date
  2012-06-23
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 粘液・サイトカイン分泌における好酸球と上皮細胞の相互作用2012
- Author(s)
  清水志乃、神前英明、清水猛史
- Organizer
  第31回気道分泌研究会
- Place of Presentation
  東京
- Year and Date
  2012-04-07
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 気道上皮細胞と好酸球の相互作用による粘液・サイトカイン分泌2012
- Author(s)
  清水志乃、神前英明、清水猛史
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大津市
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Eosinophil- epithelial cell interaction enhances mucin production and tissue remodeling2012
- Author(s)
  Shimizu S, Kouzaki H, Shimizu T
- Organizer
  The 14^<th> Japan-Korea Joint Meeting of Otorhinolaryngology -Head and Neck Surgery
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 抗原暴露による上皮細胞にけるIL-25誘導のメカニズム2012
- Author(s)
  神前英明、戸嶋一郎、紀太博仁、清水猛史
- Organizer
  第62回日本アレルギー学会秋季学術大会
- Place of Presentation
  大阪
- Year and Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] Eosinophil-epithelial cell interaction enhances mucin production and tissue remodeling2012
- Author(s)
  Shino Shimizu, Hideaki Kouzaki, Takeshi Shimizu
- Organizer
  The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Place of Presentation
  ソウル、大韓民国
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 副鼻腔粘膜上皮細胞からみた好酸球性副鼻腔炎2012
- Author(s)
  神前英明、清水志乃、清水猛史
- Organizer
  第51回日本鼻科学会
- Place of Presentation
  千葉
- Year and Date
  2012-09-29
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 空中アレルゲンはATP を介してIL-33 を放出させ、Th2 タイプの自然免疫反応を引き起こす2011
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  第29回日本耳鼻咽喉科免疫アレルギ-学会
- Place of Presentation
  大分
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 上皮細胞から放出されるIL-33とその役割2011
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  第41回日本職業・環境アレルギー学会
- Place of Presentation
  名古屋
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 空中アレルゲンはATP を介してIL-33 を放出させ、Th2 タイプの自然免疫反応を引き起こす2011
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 上気道炎症におけるリポキシンの役割2011
- Author(s)
  清水志乃、星恵理子、神前英明、清水猛史
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大分市
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-20591999
[Presentation] 上気道炎症におけるリポキシンの役割2011
- Author(s)
  清水志乃、星恵理子、神前英明, 他
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  全日空ホテルオアシスタワー(大分市)
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-20591999
[Presentation] 気道上皮細胞由来の IL-33 の放出とその役割2010
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  気道上皮細胞由来の IL-33 の放出とその役割
- Place of Presentation
  札幌
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] 気道上皮細胞由来のIL-33 の放出とその役割2010
- Author(s)
  神前英明、紀太博仁、清水猛史
- Organizer
  第60回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-22791594
[Presentation] Role of Prostaglandin E2 as a protective mediator for airway inflammation.2008
- Author(s)
  Hattori R, Shimizu S, Majima Y, Shimizu T
- Organizer
  13^<th> Asian Research Symposium in Rhinology
- Place of Presentation
  Bankok, Thailand
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-20591999
[Presentation] Prostaglandin E2 receptor (EP)agonists inhibit antigen-Induced mucus production and eosinophil infiltration in ratnasal epithelium2008
- Author(s)
  Shimizu T, Hattori R Shimizu S, Majima Y
- Organizer
  The 27^<th> international symposium of Infection and allergy of the nose
- Place of Presentation
  Crete, Greece
- Year and Date
  2008-06-17
- Data Source
  KAKENHI-PROJECT-20591999
[Presentation] Role of prostaglandin E2 as a protective mediator for airway inflammation2008
- Author(s)
  Shimizu T
- Organizer
  The 13^<th> asian research symposium in rhinology
- Place of Presentation
  Bankok, Thailand
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-20591999
[Presentation] Prostaglandin E2 receptor agonists inhibit antigen-induced mucus production and eosinophil infiltration in rat nasal epithelium.2008
- Author(s)
  Shimizu T, Hattori R, Shimizu S, Majima Y
- Organizer
  27^<th> International Symposium of Infection & Allergey of the Nose
- Place of Presentation
  Crete, Greece
- Year and Date
  2008-06-17
- Data Source
  KAKENHI-PROJECT-20591999
[Presentation] 気道上皮細胞と好酸球の相互作用による粘液・サイトカイン分泌
- Author(s)
  清水志乃、小河孝夫、戸嶋一郎、神前英明、清水猛史
- Organizer
  第112回日本耳鼻咽喉科学会学術講演会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Mucus hypersecretion in the pathogenesis of upper airway inflammation; its merits and demerits
- Author(s)
  Shimizu T
- Organizer
  10th Research Symposium on Human Natural Defense System
- Place of Presentation
  Seoul, Republic of Korea
- Year and Date
  2014-10-18 – 2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] ROle of eosinophils in tissue remodeling of chronic rhinosinusitis
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  32nd International Symposium of Infection & Allergy of Nose
- Place of Presentation
  Amsterdam, Kingdom of the Netherlands
- Year and Date
  2014-06-22 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-26462581

1. KOUZAKI Hideaki (50505592)

# of Collaborated Projects: 5 results

# of Collaborated Products: 76 results
2. KOUZAKI Hideaki (10402710)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TOJIMA Ichiro (80567347)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
4. MAJIMA Yuichi (60024791)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. YUTA Atsushi (80293778)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
6. OGAWA Takao (90549908)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. SAKAKURA Yasuo (40024723)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 新井宏幸 (60816627)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. SENO Satoshi (90378464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIBAYAMA Masayuki (20402711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HOSHI Eriko (20467385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. TOOYAMA Ikuo (20207533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ARIKATA MASAHIKO (50634383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HARADA Teruhiko (20183569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKEUCHI Kazuhiko (50206942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 安岡公美子 (80711837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山本小百合 (10828114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中多祐介 (80794958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 松本晃治 (40750138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 中村圭吾 (50848380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 川北憲人 (50915121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KITA Hirohito

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
23. 菊岡弘高

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 竹澤公美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU Takeshi 清水 猛史

Research Projects

Research Products

Co-Researchers

New mechanisms of sublingual immunotherapy for the treatment of allergic rhinitisPrincipal Investigator

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A mechanism of sublingual immunotherapy with Japanese cedar extract for the treatment of patients with Japanese cedar and cypress pollinosisPrincipal Investigator

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Review Section

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Elucidation of the pathophysiology of eosinophilic chronic rhinosinusitis focusing on the action of coagulation factors on fibroblasts and eosinophils

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Tissue remodering of eosinophilic chronic rhinosinusitisPrincipal Investigator

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Efficacy of clarithromycin against avian influenza A virus

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Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease

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Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodelingPrincipal Investigator

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The role of epithelial derived cytokines (TSLP, IL-25,IL-33) in the airway diseases

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Role of lipoxin as an inhibitory mediator in upper airway inflammationPrincipal Investigator

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Remodeling of the nose and the paranasal sinuses under diseased conditions

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Prostaglandin E_2 inhibits airway inflammationPrincipal Investigator

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Research Institution

MECHANISMS OF PROLIFERATION AND DIFFERENTIATION OF AIRWAY GLANDS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Secretory cell differentiation and mucus secretion in cultures of human nasal epithelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

SHIMIZU Takeshi 清水猛史