KITSUTAKA ATSUSHI 橘高敦史

… Alternative Names

Researcher Number	00214833
Other IDs
Affiliation (Current) *help	2018 : 帝京大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2003 – 2018 : 帝京大学, 薬学部, 教授 2000 – 2002 : 帝京大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Chemical pharmacy / Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Drug development chemistry / Applied biochemistry / Chemical pharmacy
Keywords	Principal Investigator 活性型ビタミンD_3 / ビタミンD受容体 / タキステロール / ビタミンD / ビタミンDレセプター(VDR) / ビタミンD誘導体合成 / active vitamin D_3 / 14-エピ-活性型ビタミンD_3 / 有機化学 / アゴニスト … More Except Principal Investigator 癌 / 遺伝子 / ゲノム / シトクロムP450 / 骨粗鬆症 / 有機化学 / ビタミンD / 核酸 / A環修飾ビタミンD / 活性型ビタミンD / 合成 / ビタミンDレセプター / コンホメーション / 構造活性相関 / Furansulfolene / HL-60 cell differentiation / Conformation analysis / 糖の利用 / Chemical utilization of sugars / ゲノム編集 / ビタミンD レセプター / Stereoselective synthesis / HL-60細胞分化誘導 / Structure-activity relationship / ペプチド核酸 / コンホメーション解析 / 遺伝子改変ラット / シグナル伝達 / ビタミンD受容体 / ビタミンD活性 / HL-60細胞分化誘導能 / Vitamin D receptor / フラン縮環3-スルホレン / 酵素 / 糖の化学的利用 / リガンド・レセプター複合体 / A-Ring modified vitamin D / 立体選択的合成 / フランスルホレン Less

Elongation of half-life time of vitamin D receptor ligands: acquisition of metabolic resistance and development of selective inhibitors against inactivation enzyme of vitamin DPrincipal InvestigatorOngoing
- Principal Investigator
  
  橘高敦史
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Teikyo University
ゲノム編集法により作製した遺伝子改変ラットを用いたビタミンD誘導体評価系の構築Ongoing
- Principal Investigator
  
  榊利之
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University
ビタミンＤ由来光反応異性体の新規構造展開：骨作用増強と生体内半減期増長分子の開発Principal InvestigatorOngoing
- Principal Investigator
  
  橘高敦史
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Study and development of a 14-epi-tachysterol skeleton and enhancing bone formation via flexibility of ligand binding domain of vitamin D receptorPrincipal Investigator
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Design and synthesis of chiral peptide nucleic acid for antigene therapeutics
- Principal Investigator
  
  SUGIYAMA TORU
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Teikyo University
  The University of Tokyo
Protein Engineering of vitamin D hydroxylases and design of their inhibitors based on their tertiary structure
- Principal Investigator
  
  SAKAKI Toshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University
Study on structural development of novel 14-epi-19-norprevitamin D type seco-steroids working on bone formationPrincipal Investigator
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Design and development of antigene agents based on strand invasion mechanism
- Principal Investigator
  
  SUGIYAMA Toru
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
14-epi-Previtamin D Analogs : Design and Synthesis of Selective Ligands for Nuclear Receptor and Membrane ReceptorPrincipal Investigator
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Development of selective nuclear receptor modulators with a 2,25-modified seco-steroidal skeletonPrincipal Investigator
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Design and Synthesis of Vitamin D Receptor Antagonists : Remedy for Pagets DeseasePrincipal Investigator
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
DMA Lesions on the Specific Site in the Transcription Factor Binding Domain with RecA-Oligonucleotide ComplexesPrincipal Investigator
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Organic Chemical Creation of Substances with Novel Function and Its Application
- Principal Investigator
  
  TAKAYAMA Hiroaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University

[Book] スタンダード薬学シリーズⅡ ３　化学系薬学Ⅲ.「自然が生み出す薬物」2016
- Author(s)
  橘高敦史　領域担当編集
- Total Pages
  334
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-15K07869
[Book] スタンダード薬学シリーズⅡ ３　化学系薬学Ⅱ.「生体分子・医薬品の化学による理解」2016
- Author(s)
  橘高敦史
- Total Pages
  346
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-15K07869
[Book] Vitamins and Hormones Vol. 1002016
- Author(s)
  Atsushi Kittaka, Masashi Takano, and Hiroshi Saitoh
- Total Pages
  473
- Publisher
  Elsevier Inc. Academic Press: Burlington
- Data Source
  KAKENHI-PROJECT-15K07869
[Book] Vitamins and Hormones Vol. 1002016
- Author(s)
  Eiji Munetsuna, Atsushi Kittaka, Tai C. Chen, and Toshiyuki Sakaki
- Total Pages
  473
- Publisher
  Elsevier Inc. Academic Press: Burlington
- Data Source
  KAKENHI-PROJECT-15K07869
[Book] スタンダード薬学シリーズⅡ ３　化学系薬学Ⅰ.「化学物質の性質と反応」2015
- Author(s)
  橘高敦史　領域担当編集
- Total Pages
  445
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-24590021
[Book] ビタミンDと疾患～基礎の理解と臨床への応用～2014
- Author(s)
  岡野登志夫編、橘高敦史共著
- Total Pages
  246
- Publisher
  医薬ジャーナル社（大阪）
- Data Source
  KAKENHI-PROJECT-24590021
[Book] 薬学用語辞典2012
- Author(s)
  橘高敦史
- Total Pages
  535
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-21380067
[Book] 薬学用語辞典2012
- Author(s)
  橘高敦史
- Total Pages
  535
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-21590022
[Book] 薬学用語辞典2012
- Author(s)
  橘高敦史
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-21380067
[Book] 薬学用語辞典2012
- Author(s)
  橘高敦史, ら
- Total Pages
  535
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-21590022
[Book] ビタミン総合事典2010
- Author(s)
  榊利之, 橘高敦史, 他158名
- Total Pages
  624
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21380067
[Book] ビタミン総合事典2010
- Author(s)
  榊利之、橘高敦史(他158名)
- Total Pages
  624
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21380067
[Book] ビタミン総合事典2010
- Author(s)
  橘高敦史, ら
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21590022
[Book] 創薬科学・医薬化学2007
- Author(s)
  橘高敦史
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-19590016
[Book] スタンダード薬学シリーズ3 化学系薬学 IV演習編2007
- Author(s)
  橘高敦史
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-19590016
[Book] 創薬科学・医薬化学14章抗菌薬、15章抗がん剤、16章抗エイズ薬、17章骨粗鬆症治療薬と高齢化2007
- Author(s)
  橘高敦史編著
- Publisher
  化学同人(京都)
- Data Source
  KAKENHI-PROJECT-19590016
[Book] 「スタンダード薬学シリーズ3化学系薬学IV演習編」第I部13 章、15 章(SBO 75,76)、第II部1章(SBO 7, 8, 9).2007
- Author(s)
  橘高敦史分担執筆
- Publisher
  日本薬学会編東京化学同人(東京)
- Data Source
  KAKENHI-PROJECT-19590016
[Book] 知っておきたい有機反応1002006
- Author(s)
  橘高敦史
- Publisher
  東京化学同人
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Book] スタンダード薬学シリーズ3 化学系薬学II. ターゲット分子の合成と生体分子・医薬品の化学 SBO 24, 27, 28, 50.2005
- Author(s)
  橘高敦史
- Publisher
  東京化学同人
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Book] スタンダード薬学シリーズ3 化学系薬学II.ターゲット分子の合成と生体分子・医薬品の化学 SBO 24,27,28,50.2005
- Author(s)
  橘高敦史
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-17590012
[Book] メディシナルケミストリー第5章「受容体での薬物作用」2003
- Author(s)
  橘高敦史(翻訳)
- Publisher
  丸善株式会社(東京・日本橋)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Book] スタンダ-ド薬学シリ-ズ化学系薬学演習編
- Author(s)
  橘高敦史
- Publisher
  東京化学同人(印刷中)
- Data Source
  KAKENHI-PROJECT-17590012
[Book] 創薬科学
- Author(s)
  橘高敦史
- Publisher
  化学同人(印刷中)
- Data Source
  KAKENHI-PROJECT-17590012
[Book] 創薬科学
- Author(s)
  橘高敦史
- Publisher
  化学同人(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Book] スタンダード薬学シリーズ化学系薬学演習編
- Author(s)
  橘高敦史
- Publisher
  東京化学同人(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: Based on synthesis and X-ray co-crystallographic analysis with human vitamin D receptor2018
- Author(s)
  Daisuke Sawada, Shinji Kakuda, Akiko Takeuchi, Fumihiro Kawagoe, Midori Takimoto-Kamimura, and Atsushi Kittaka
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume : 16 (14) Pages : 2448-2455
- DOI
  10.1039/c8ob00158h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Peptide Nucleic Acid Possessing PreQ1 as a Cationic Analogue of Guanine2018
- Author(s)
  Toru Sugiyama, Misaki Kohara, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
- Journal Title
  
  Peptide Science 2017
  
  Volume : 54 Pages : 192-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Metabolism of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D 3 by CYP24A1 and biological activity of its 24 R -hydroxylated metabolite2018
- Author(s)
  Kaori Yasuda, Eri Tohyama, Masashi Takano, Atsushi Kittaka, Miho Ohta, Shinichi Ikushiro, and Toshiyuki Sakaki
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume : 178 (4) Pages : 333-339
- DOI
  10.1016/j.jsbmb.2018.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-17K15261
[Journal Article] Specific interactions between vitamin D receptor and ligand depending on its chirality: ab initio fragment molecular orbital calculations2018
- Author(s)
  Ryosuke Takeda, Rie Suzuki, Ittetsu Kobayashi, Kentaro Kawai, Atsushi Kittaka, Midori Takimoto-Kamimura, and Noriyuki Kurita
- Journal Title
  
  Chem-Bio Inform. J.
  
  Volume : 18 Pages : 32-43
- DOI
  10.1273/cbij.18.32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Proposal of potent inhibitors for vitamin-D receptor based on ab initio fragment molecular orbital calculations2018
- Author(s)
  Ryosuke Takeda, Ittetsu Kobayashi, Rie Suzuki, Kentaro Kawai, Atsushi Kittaka, Midori Takimoto-Kamimura, and Noriyuki Kurita
- Journal Title
  
  Journal of Molecular Graphics and Modelling
  
  Volume : 80 (3) Pages : 320-326
- DOI
  10.1016/j.jmgm.2018.01.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Recent Developments for Introducing a Hexafluoroisopropanol Unit into the Vitamin D Side Chain2018
- Author(s)
  Fumihiro Kawagoe, Toru Sugiyama, Motonari Uesugi, and Atsushi Kittaka
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 177 (3) Pages : 250-254
- DOI
  10.1016/j.jsbmb.2017.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique2018
- Author(s)
  Hiroki Mano, Shinichi Ikushiro, Nozomi Saito, Atsushi Kittaka, and Toshiyuki Sakaki
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume : 178 (4) Pages : 55-59
- DOI
  10.1016/j.jsbmb.2017.10.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-16K14904
[Journal Article] Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor2017
- Author(s)
  H Mano M Nishikawa K Yasuda S Ikushiro N Saito D Sawada S Honzawa M Takano A Kittaka T Sakaki
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 167 Pages : 61-66
- DOI
  10.1016/j.jsbmb.2016.11.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-26460008, KAKENHI-PROJECT-16K14904, KAKENHI-PROJECT-17K15261, KAKENHI-PROJECT-15K18686
[Journal Article] 効率的ファレカルシトリオール側鎖構造の構築2017
- Author(s)
  川越文裕、杉山亨、上杉志成、橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 91 (4) Pages : 277-277
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 高感度かつ短時間にビタミンD誘導体のVDR親和性を評価するシステムの開発2017
- Author(s)
  真野寛生、生城真一、高野真史、橘高敦史、榊利之
- Journal Title
  
  ビタミン
  
  Volume : 91 (4) Pages : 263-263
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Preparation of New Fmoc 2-Thiouracil Monomer for the Synthesis of Pseudo-complementary PNA2017
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Peptide Science 2016
  
  Volume : 53 Pages : 217-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] ビタミンD誘導体AH-1のCYP24A1代謝物24位エピマーの合成2017
- Author(s)
  高野真史、安田佳織、真野寛生、遠山枝李、榊　利之、橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 91 (4) Pages : 277-277
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Synthesis　of 2α- and 2β-(3-hydroxypropyl)-7,8-cis-14-epi-1α,25-dihydroxy-19-norvitamin D3 and their biological activity2017
- Author(s)
  Daisuke Sawada, Eiji Ochiai, Akiko Takeuchi, Shinji Kakuda, Midori Kamimura-Takimoto, Fumihiro Kawagoe, and Atsushi Kittaka
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 167
- DOI
  10.1016/j.jsbmb.2016.09.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460008, KAKENHI-PROJECT-15K07869
[Journal Article] 1α,25(OH)2D3 Analog, MART-10, Inhibits Neuroendocrine Tumor Cell Metastasis After VEGF-A Stimulation2017
- Author(s)
  Kun-Chun Chiang, Chun-Nan Yeh, Jong-Hwei S. Pang, Jun-Te Hsu, Ta-Sen Yeh, Li-Wei Chen, Sheng-Fong Kuo, Masashi Takano, Tai C. Chen, Atsushi Kittaka, Po-Jen Hsieh, Horng-Heng Juang
- Journal Title
  
  Anticancer Res.
  
  Volume : 37 (11) Pages : 6215-6221
- DOI
  10.21873/anticanres.12072
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA2017
- Author(s)
  Toru Sugiyama, Genki Hasegawa, Chie Niikura, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume : 27 (15) Pages : 3337-3341
- DOI
  10.1016/j.bmcl.2017.06.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Synthesis of the CYP24A1 major metabolite of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D 32017
- Author(s)
  Masashi Takano, Kaori Yasuda, Eri Tohyama, Erika Higuchi, Toshiyuki Sakaki, and Atsushi Kittaka
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume : 印刷中 Pages : 75-78
- DOI
  10.1016/j.jsbmb.2016.11.022
- Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-17K15261, KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-15K18686, KAKENHI-PROJECT-15K08031
[Journal Article] Specific interactions between vitamin-D receptor and its ligands: ab initio molecular orbital calculations in water2017
- Author(s)
  Ryosuke Takeda, Ittetsu Kobayashi, Kanako Shimamura, Hiromi Ishimura, Ryushi Kadoya, Kentaro Kawai, Atsushi Kittaka, Midori Takimoto-Kamimura and Noriyuki Kurita
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 印刷中
- DOI
  10.1016/j.jsbmb.2017.02.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] MART-10 represses cholangiocarcinoma cell growth and high vitamin D receptor expression indicates better prognosis for cholangiocarcinoma2017
- Author(s)
  Kun-Chun Chiang, Ta-Sen Yeh, Cheng-Cheng Huang, Yu-Chan Chang, Horng-Heng Juang, Chi-Tung Cheng, Jong-Hwei S. Pang, Jun-Te Hsu, Masashi Takano, Tai C. Chen, Atsushi Kittaka, Michael Hsiao, and Chun-Nan Yeh
- Journal Title
  
  Sci. Rep.
  
  Volume : 7
- DOI
  10.1038/srep43773
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] ビタミンD受容体(VDR)の活性を制御するノンセコステロイド型VDRリガンドの創製2017
- Author(s)
  三澤隆史、出水庸介、谷内出友美、大岡伸通、野尻久雄、橘高敦史、槇島　誠、内藤幹彦、栗原正明
- Journal Title
  
  ビタミン
  
  Volume : 91 Pages : 113-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 分割型ルシフェラーゼを用いたビタミンD受容体リガンド検出系の構築および化合物スクリーニングへの応用2017
- Author(s)
  真野寛生、生城真一、高野真史、橘高敦史、榊　利之
- Journal Title
  
  ビタミン
  
  Volume : 91 Pages : 165-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] ビタミンD誘導体合成：制がんおよび骨形成活性への効果2017
- Author(s)
  橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 91 Pages : 174-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 分割型ルシフェラーゼを用いたビタミンD受容体リガンド検出バイオセンサーの応用2016
- Author(s)
  真野寛生、西川美宇、安田佳織、生城真一、高野真史、橘高敦史、榊利之
- Journal Title
  
  ビタミン
  
  Volume : 90 Pages : 221-221
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 2α位にアゾール基を有するビタミンＤ誘導体の代謝および骨密度上昇作用メカニズムの解明2016
- Author(s)
  遠山枝李、安田佳織、真野寛生、鎌倉昌樹、生城真一、太田美穂、高野真史、橘高敦史、榊利之
- Journal Title
  
  ビタミン
  
  Volume : 90 Pages : 191-191
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 2α-[2-(テトラゾール-2-イル)エチル]-1α,24,25-トリヒドロキシビタミンD3の合成2016
- Author(s)
  高野真史，安田佳織，遠山枝李，榊利之，橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 90 Pages : 196-196
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 短い側鎖を有する19-ノルビタミンD誘導体の合成と生物活性評価2016
- Author(s)
  川越文裕、安田佳織、高野真史、松本洋太郎、竹内明子、杉山亨、上杉志成、榊利之、橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 90 Pages : 195-195
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 25-ヒドロキシビタミンD3ラクトン代謝物と異性体の合成研究2016
- Author(s)
  樋口恵理香、杉山亨、高野真史、上杉志成、橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 90 Pages : 195-195
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] ビタミンD受容体 (VDR) の活性を制御するノンセコステロイド型VDRリガンドの創製2016
- Author(s)
  三澤隆史、出水庸介、谷内出友美、大岡伸通、木下恵愛、野尻久雄、橘高敦史、槇島誠、内藤幹彦、栗原正明
- Journal Title
  
  ビタミン
  
  Volume : 90 Pages : 197-197
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Synthesis, metabolism, and biological activity of 2-[3-(tetrazolyl)propyl]-1a,25-dihydroxy-19-norvitamin D32016
- Author(s)
  Masashi Takano, Kaori Yasuda, Erika Higuchi, Eri Tohyama, Akiko Takeuchi, Toshiyuki Sakaki, and Atsushi Kittaka
- Journal Title
  
  J Steroid Biochem Mol Biol.
  
  Volume : in press Pages : 40-44
- DOI
  10.1016/j.jsbmb.2015.07.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-15K18686
[Journal Article] MART-10, the new brand of 1α,25(OH)2D3 analog, is a potent anti-angiogenic agent in vivo and in vitro2016
- Author(s)
  Kun Chun Chiang, Chi-Chin Sun, Ming-Huang Chen, Chi-Ying Huang, Jun-Te Hsu, Ta-Sen Yeh, Li-Wei Chen, Sheng-Fong Kuo, Horng-Heng Juang, Masashi Takano, Atsushi Kittaka, Tai C. Chen, Chun Nan Yeh, Jong-Hwei S. Pang
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 155 Pages : 26-34
- DOI
  10.1016/j.jsbmb.2015.09.022
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Revisiting the 7,8-cis-vitamin D3 derivatives: synthesis, evaluating the biological activity, and study of the binding configuration2016
- Author(s)
  Daisuke Sawada, Shinji Kakuda, Midori Kamimura-Takimoto, Akiko Takeuchi, Yotaro Matsumoto, Atsushi Kittaka
- Journal Title
  
  Tetrahedron
  
  Volume : 72 Pages : 2838-2948
- DOI
  10.1016/j.tet.2016.03.081
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460008, KAKENHI-PROJECT-15K07869
[Journal Article] 7,8-cis-19-Norvitamin D3の合成とVDR結合および7,8-cis-vitamin D3の化学的性質2016
- Author(s)
  澤田大介、松本洋太郎、川越文裕、竹内明子、角田真二、上村みどり、橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 90 Pages : 84-85
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Peptide Nucleic Acid with a Lysine side chain at the beta-Position: Synthesis and Application for DNA Cleavage2016
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume : in press
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA2016
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Journal Title
  
  Peptide Science
  
  Volume : 2015 Pages : 307-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590135
[Journal Article] Peptide Nucleic Acid with a Lysine side chain at the β-Position: Synthesis and Application for DNA Cleavage2016
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume : 64
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590135
[Journal Article] 1α,25(OH)2D3 Analog, MART-10, Inhibits Neuroendocrine Tumor Cell Growth Through Induction of G0/G1 Cell-cycle Arrest and Apoptosis2016
- Author(s)
  Kun Chun Chiang, Chun-Nan Yeh, Jong-Hwei S. Pang, Jun-Te Hsu, Ta-Sen Yeh, Li-Wei Chen, Sheng-Fong Kuo, Po-Jen Hsieh, Yi-Chun Pan, Masashi Takano, Tai C. Chen, Tsui-Hsia Feng, Atsushi Kittaka, and Horng-Heng Juang
- Journal Title
  
  Anticancer Res.
  
  Volume : 36 Pages : 3307-3313
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 25(OH)D is effective to repress human cholangiocarcinoma cell growth through the conversion of 25(OH)D to 1α,25(OH)2D32016
- Author(s)
  Kun-Chun Chiang, Chun-Nan Yeh, Cheng-cheng Huang, Ta-Sen Yeh, Jong-Hwei S. Pang, Jun-Te Hsu, Li-Wei Chen, Sheng-Fong Kuo, Atsushi Kittaka, Tai C. Chen, and Horng-Heng Juang
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume : 17
- DOI
  10.3390/ijms17081326
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Synthesis of PNA Oligomers Containing Modified Deazaguanines for the Development of Functional PNA2016
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Peptide Science 2015
  
  Volume : 52 Pages : 307-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Peptide nucleic acid with a lysine side chain at the beta-position: synthesis and application for DNA cleavage2016
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume : 64 Pages : 817-823
- DOI
  10.1248/cpb.c16-00191
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-26460169
[Journal Article] Efficient N-Acyldopamine Synthesis2016
- Author(s)
  Yotaro Matsumoto, Akihiro Ito, Motonari Uesugi, and Atsushi Kittaka
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume : 64 Pages : 935-940
- DOI
  10.1248/cpb.c16-00162
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] The vitamin D analog, MART-10, attenuates triple negative breast cancer cells metastatic potential2016
- Author(s)
  Kun-Chun Chiang, Ta-Sen Yeh, Shin-Cheh Chen, Jong-Hwei S. Pang, Chun-Nan Yeh, Jun-Te Hsu, Li-Wei Chen, Sheng-Fong Kuo, Masashi Takano, Atsushi Kittaka, Tai C. Chen, Chi-Chin Sun, and Horng-Heng Juang
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume : 17 Pages : 606-619
- DOI
  10.3390/ijms17040606
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells2016
- Author(s)
  Shih-Wei Yang, Chi-Ying Tsai, Yi-Chun Pan, Chun-Nan Yeh, Jong-Hwei S. Pang, Masashi Takano, Atsushi Kittaka, Horng-Heng Juang, Tai C. Chen, and Kun-Chun Chiang
- Journal Title
  
  Drug Design, Development and Therapy
  
  Volume : 10 Pages : 1995-2002
- DOI
  10.2147/dddt.s107256
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] MART-10, the Vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential2015
- Author(s)
  Kun-Chun Chiang, Sheng-Fong Kuo, Chih-Hung Chen, Sohching Ng, Shu-Fu Lin, Chun-Nan Yeh, Li-Wei Chen, Masashi Takano, Tai C. Chen, Horng-Heng Juang, Atsushi Kittaka, Jen-Der Lin, Jong-Hwei S. Pang
- Journal Title
  
  Cancer Letters
  
  Volume : 369 Pages : 76-85
- DOI
  10.1016/j.canlet.2015.07.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Modified Deazaguanines for the Synthesis of PNA2015
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Peptide Science 2014
  
  Volume : 51 Pages : 87-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Hepatocellular carcinoma cells express 25(OH)D-1α-hydroxylase and are able to convert 25(OH)D to 1α,25(OH)2D, leading to the 25(OH)D-induced growth inhibition2015
- Author(s)
  Kun-Chun Chiang, Cho-Li Yen, Chun-Nan Yeh, Jun-Te Hsu, Li-Wei Chen, Sheng-Fong Kuo, Shang-Yu Wang, Chi-Chin Sun, Atsushi Kittaka, Tai C. Chen, Ta-Sen Yeh, Shu-Yuan Hsu, Horng-Heng Juang
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 154 Pages : 47-52
- DOI
  10.1016/j.jsbmb.2015.06.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton.2015
- Author(s)
  Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Bioorganic Medicinal chemistry letter
  
  Volume : 25 Pages : 5362-5366
- DOI
  10.1016/j.bmcl.2015.09.030
- Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049
[Journal Article] 細胞選択的及び遺伝子選択的活性を有するビタミンD誘導体の生物活性評価2015
- Author(s)
  石澤通康、高野真史、橘高敦史、坂根里枝、須原義智、山田幸子、槇島　誠
- Journal Title
  
  ビタミン
  
  Volume : 89 Pages : 39-39
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] ビタミンD受容体リガンドの創製2015
- Author(s)
  橘高敦史、澤田大介
- Journal Title
  
  ファルマシア
  
  Volume : 51 Pages : 196-200
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] 分割型ルシフェラーゼを用いたビタミンDバイオセンサーの開発2015
- Author(s)
  真野寛生、西川美宇、安田佳織、鎌倉昌樹、生城真一、高野真史、斉藤望、橘高敦史、榊利之
- Journal Title
  
  ビタミン
  
  Volume : 89 Pages : 264-264
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 強い骨密度上昇作用を有するビタミンD誘導体の代謝様式の解明2015
- Author(s)
  遠山枝李、安田佳織、生城真一、鎌倉昌樹、高野真史、橘高敦史、榊　利之
- Journal Title
  
  ビタミン
  
  Volume : 89 Pages : 258-258
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 2α位にトリアゾリルプロピル基を有する19-ノル型ビタミンD3の合成と生物活性評価2015
- Author(s)
  高野真史、樋口恵理香、安田佳織、榊　利之、橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 89 Pages : 232-232
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] SYNTHESIS AND PRELIMINARY BIOLOGICAL EVALUATION OF 2-[3-(TETRAZOLYL)PROPYL]-1α,25-DIHYDROXY-19-NORVITAMIN D32015
- Author(s)
  Masashi Takano, Erika Higuchi, Kazunari Higashi, Keisuke Hirano, Akiko Takeuchi, Daisuke Sawada, and Atsushi Kittaka
- Journal Title
  
  Heterocycles
  
  Volume : 90 Pages : 1274-1287
- DOI
  10.3987/com-14-s(k)108
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590021, KAKENHI-PROJECT-25860011, KAKENHI-PROJECT-26460008
[Journal Article] Modified deazaguanines for the synthesis of PNA2015
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Journal Title
  
  Peptide Science
  
  Volume : 2014 Pages : 87-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590135
[Journal Article] Vitamin D & Analogues in Cancer Prevention & Therapy Research2015
- Author(s)
  Tai C. Chen, Toshiyuki Sakaki, and Atsushi Kittaka
- Journal Title
  
  Adjacent Government
  
  Volume : 7 Pages : 66-67
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] Development of bioluminescent sensor to detect vitamin D receptor ligands in the living cells2015
- Author(s)
  Hiroki Mano, Miyu Nishikawa, Kaori Yasuda, Shinichi Ikushiro, Nozomi Saito, Masashi Takano, Atsushi Kittaka, and Toshiyuki Sakaki
- Journal Title
  
  Bioconjug Chem
  
  Volume : 26 Pages : 2038-2045
- DOI
  10.1021/acs.bioconjchem.5b00433
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-25292062, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-15K18686
[Journal Article] 19-Norvitamin D Analogs for Breast Cancer Therapy2015
- Author(s)
  Yotaro Matsumoto, Atsushi Kittaka, and Tai C. Chen
- Journal Title
  
  Can. J. Physiol. Pharmacol.
  
  Volume : 93 Pages : 333-348
- DOI
  10.1139/cjpp-2014-0452
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Journal Article] 19-Norvitamin D Analogs for Breast Cancer Therapy2015
- Author(s)
  Yotaro Matsumoto, Atsushi Kittaka, and Tai C. Chen
- Journal Title
  
  Canadian Journal of Physiol. Pharmacol.
  
  Volume : 93 Pages : 123-149
- DOI
  10.1139/cjpp-2014-0356
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Modified Deazaguanines for the Synthesis of PNA2015
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Peptide Science 2014
  
  Volume : 51 Pages : 87-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] A Peptide Nucleic Acid to Reduce Type I Collagen Production by Fibroblast Cells2015
- Author(s)
  Yasutada Imamura, Suzuka Tsuboi, Toru Sugiyama, Atsushi Kittaka, and Yonchol Shin
- Journal Title
  
  Open Journal of Medicinal Chemistry
  
  Volume : 5 Pages : 1-8
- DOI
  10.4236/ojmc.2015.51001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590021, KAKENHI-PROJECT-24590135
[Journal Article] Synthesis and metabolic studies of 1α,2α,25-, 1α,4α,25- and 1α,4β,25-trihydroxyvitamin D32015
- Author(s)
  Masashi Takano, Daisuke Sawada, Kaori Yasuda, Miyu Nishikawa, Akiko Takeuchi, Ken-ichiro Takagi, Kyohei Horie, G. Satyanarayana Reddy, Tai C. Chen, Toshiyuki Sakaki, and Atsushi Kittaka
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 148 Pages : 34-37
- DOI
  10.1016/j.jsbmb.2014.09.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590021, KAKENHI-PROJECT-26460008
[Journal Article] Design and synthesis of 2α-(tetrazolylethyl)-1α,25-dihydroxyvitamin D_3 as a high affinity ligand for vitamin D receptor2014
- Author(s)
  Miki Matsuo, Asami Hasegawa, Masashi Takano, Hiroshi Saito, Shinji Kakuda, Kenichiro Takagi, Eiji Ochiai, Kyohei Horie, Midori Takimoto-Kamimura, Kazuya Takenouchi, Daisuke Sawada, and Atsushi Kittaka
- Journal Title
  
  J. Steroid Biochem. Mol. Biol
  
  Volume : 140 Pages : 201-203
- DOI
  10.1016/j.jsbmb.2013.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021, KAKENHI-PROJECT-26460008, KAKENHI-PROJECT-23590015
[Journal Article] Sequence-Specific Cleavage of DNA by β-Peptide Nucleic Acid Bearing a Pendant Metal Complex2014
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Peptide Science 2013
  
  Volume : 50 Pages : 369-370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Chemopreventive and Chemotherapeutic Effect of Dietary Supplementation of Vitamin D on Cholangiocarcinoma in a Chemical-Induced Animal Model2014
- Author(s)
  Kun-Chun Chiang, Chun-Nan Yeh, Kun-Ju Lin, Li-Jen Su, Tzu-Chen Yen, Jong-Hwei S. Pang, Atsushi Kittaka, Chi-Chin Sun, Miin-Fu Chen, Yi-Yin Jan, Horng-Heng Juang, Ta-Sen Yeh, and Tai C. Chen
- Journal Title
  
  Oncotarget
  
  Volume : 5 Pages : 3849-3861
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] メチルステロール酸化酵素SC4MOLによる2位置換基付加型ビタミンD誘導体の代謝2014
- Author(s)
  安田佳織、岩永由麻、小川和亮、生城真一、鎌倉昌樹、高野真史、齋藤　望、橘高敦史、藤島利江、太田美穂、榊　利之
- Journal Title
  
  ビタミン
  
  Volume : 88 Pages : 243-243
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Synthesis and Biological Activity of 1α,2α,25-Trihydroxyvitamin D3: Active Metabolite of 2α-(3-Hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by Human CYP3A42014
- Author(s)
  Masashi Takano, Saori Ohya, Kaori Yasuda, Miyu Nishikawa, Akiko Takeuchi, Daisuke Sawada, Toshiyuki Sakaki, and Atsushi Kittaka
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume : 62 (2) Pages : 182-184
- DOI
  10.1248/cpb.c13-00646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590015, KAKENHI-PROJECT-24590021, KAKENHI-PROJECT-25860011, KAKENHI-PROJECT-26460008
[Journal Article] 2α位にテトラゾールプロピル基を有する19-ノル型ビタミンD3の合成と生物活性評価2014
- Author(s)
  高野真史、樋口恵理香、竹内明子、澤田大介、橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 88 Pages : 244-244
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] MART-10, a Less Calcemic Vitamin D Analog, Is More Potent Than 1,25-Dihydroxyvitamin D3 in Inhibiting the Metastatic Potential of MCF-7 Breast Cancer Cells in Vitro2014
- Author(s)
  Kun-Chun Chiang, Shin-Cheh Chen, Chun-Nan Yeh, Jong-Hwei S. Pang, Shih-Che Shen, Jun-Te Hsu, Yu-Yin Liu, Li-Wei Chen, Sheng-Fong Kuo, Masashi Takano, Atsushi Kittaka, Chi-Chin Sun, Horng-Heng Juang, and Tai C. Chen
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 139 Pages : 54-60
- DOI
  10.1016/j.jsbmb.2013.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Vitamin D against Cancer2014
- Author(s)
  Tai C. Chen, Atsushi Kittaka, and Gunnar Norstedt
- Journal Title
  
  International Innovation
  
  Volume : 157 Pages : 18-19
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] The Vitamin D analog, MART-10, represses metastasis potential via downregulation of epithelial-mesenchymal transition in pancreatic cancer cells2014
- Author(s)
  Kun-Chun Chiang, Chun-Nan Yeh, Jun-Te Hsu, Yi-Yin Jan, Li-Wei Chen, Sheng-Fong Kuo, Masashi Takano, Atsushi Kittaka, Tai-C Chen, Wen-Tsung Chen, Jong-Hwei S.Pang, Ta-Sen Yeh, and Horng-Heng Juang
- Journal Title
  
  Cancer Letters
  
  Volume : 354 Pages : 235-244
- DOI
  10.1016/j.canlet.2014.08.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Synthesis and properties of 14-epi-1a,25-dihydroxy-19-nortachysterol and its 2-substituted derivatives2014
- Author(s)
  Daisuke Sawada and Atsushi Kittaka
- Journal Title
  
  Current Topics in Medicinal Chemistry
  
  Volume : 14 Pages : 2454-2459
- DOI
  10.2174/1568026615666141208103741
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590021, KAKENHI-PROJECT-26460008
[Journal Article] Sequence-specific cleavage of DNA by β-peptide nucleic acid bearing a pendant metal complex2014
- Author(s)
  Toru Sugiyama, keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Journal Title
  
  Peptide Science
  
  Volume : 2013 Pages : 369-370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590135
[Journal Article] CYP24A1 as a Potential Target for Cancer Therapy2014
- Author(s)
  Toshiyuki Sakaki, Kaori Yasuda, Atsushi Kittaka, Keiko Yamamoto, and Tai C. Chen
- Journal Title
  
  Anti-Cancer Agents Med. Chem.
  
  Volume : 14 Pages : 97-108
- DOI
  10.2174/18715206113139990307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone2013
- Author(s)
  Toru Sugiyama and Atsushi Kittaka
- Journal Title
  
  Molecules
  
  Volume : 18 Pages : 287-310
- DOI
  10.3390/molecules18010287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Synthesis of 2α-Heteroarylalkyl Active Vitamin D3 with Therapeutic Effect on Enhancing Bone Mineral Density in vivo2013
- Author(s)
  Miki Matsuo, Asami Hasegawa, Masashi Takano, Hiroshi Saito, Shinji Kakuda, Takayuki Chida, Ken-ichiro Takagi, Eiji Ochiai, Kyohei Horie, Yoshifumi Harada, Midori Takimoto-Kamimura, Kazuya Takenouchi, Daisuke Sawada, and Atsushi Kittaka
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume : 4 (7) Pages : 671-674
- DOI
  10.1021/ml400098w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590015, KAKENHI-PROJECT-24590021
[Journal Article] Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone2013
- Author(s)
  Toru Sugiyama, Atsushi Kittaka
- Journal Title
  
  Molecules
  
  Volume : 18 Pages : 287-310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099
[Journal Article] 14-エピ-タキステロール類の合成とVDR結合様式の解明2013
- Author(s)
  澤田大介、堀江恭平、落合鋭士、竹内明子、角田真二、上村みどり、橘高敦史
- Journal Title
  
  ビタミン
  
  Volume : 87 Pages : 220-220
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] 2α-アゾールエチル基を有する1α,25-ジヒドロキシビタミンD3の合成と生物活性評価2013
- Author(s)
  橘高敦史、松尾実紀、長谷川麻美、高野真史、澤田大介、齋藤　博、角田真二、高木健一郎、落合鋭士、堀江恭平、上村みどり、竹之内一弥
- Journal Title
  
  ビタミン
  
  Volume : 87 Pages : 652-652
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Synthesis of β-Chiral Peptide Nucleic Acids Bearing Lysine Side Chains2013
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Peptide Science 2012
  
  Volume : 49 Pages : 385-386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] MART-10, a Novel Vitamin D Analog, Inhibits Head and Neck Squamous Carcinoma Cells Growth through Cell Cycle Arrest at G0/G1 with Upregulation of p21 and p27 and Downregulation of Telomerase2013
- Author(s)
  Kunchun Chiang, Chun-Nan Yeh, Jun-Te Hsu, Li-Wei Chen, Sheng-Fong Kuo, Chi-Chin Sun, Cheng-Cheng Huang, Jong-Hwei S. Pang, John N. Flanagan, Masashi Takano, Atsushi Kittaka, Horng-Heng Juang, Shih-Wei Yang and Tai C. Chen
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume : 138 Pages : 427-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] The roles of cytochrome P450 enzymes in prostate cancer development and treatment2012
- Author(s)
  Chen TC, Sakaki T, Yamamoto K, Kittaka A
- Journal Title
  
  Anticancer Res
  
  Volume : 32 Pages : 291-298
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of ss-chiral peptide nucleic acids and their DNA binding properties2012
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Journal Title
  
  Peptide Science 2011
  
  Pages : 353-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099
[Journal Article] Potent 19-Norvitamin D Analogs for Prostate and Liver Cancer Therapy2012
- Author(s)
  Atsushi Kittaka, Akihiro Yoshida, Kun-Chun Chiang, Masashi Takano, Daisuke Sawada, Toshiyuki Sakaki, and Tai C. Chen
- Journal Title
  
  Future Med. Chem.
  
  Volume : 4 (16) Pages : 2049-2065
- DOI
  10.4155/fmc.12.130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590015, KAKENHI-PROJECT-24590021
[Journal Article] The Difference between 14-Epi-previtamin D_3 and 14-Epi-19-norprevitamin D_3 : Their Synthesis and Binding Affinity for Human VDR2012
- Author(s)
  Sawada D, Kittaka A., 他6名
- Journal Title
  
  Anticancer Res
  
  Volume : 32 Pages : 319-326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] C15-Functionalized 16-Ene-1α,25-dihydroxyvitamin D_3 is a New Vitamin D Analog with Unique Biological Properties2012
- Author(s)
  Kumagai G, Kittaka A., 他10名
- Journal Title
  
  Anticancer Res
  
  Volume : 32 Pages : 311-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] The Roles of Cytochrome P-450 Enzymes in Prostate Cancer Development and Treatment2012
- Author(s)
  Tai C. Chen, Toshiyuki Sakaki, Keiko Yamamoto, and Atsushi Kittaka
- Journal Title
  
  Anticancer Res
  
  Volume : 32 Pages : 291-298
- URL
  http://ar.iiarjournals.org/content/32/1/291.full?sid=d6507568-bc32-4ba6-841c-6b606396458b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] C15-Functionalized 16-Ene-1., 25-dihydroxyvitamin D3 is a New Vitamin D Analog with Unique Biological Properties2012
- Author(s)
  Go Kumagai, Masashi Takano, Kanako Shindo, Daisuke Sawada, Nozomi Saito, Hiroshi Saito, Sshinji Kakuda, Ken-ichiro Takagi, Midori Takimoto-Kamimura, Kazuya Takenouchi, Tai C. Chen and Atsushi Kittaka
- Journal Title
  
  Anticancer Res
  
  Volume : 32 Pages : 311-318
- URL
  http://ar.iiarjournals.org/content/32/1/311.full?sid=d6507568-bc32-4ba6-841c-6b606396458b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] The Difference between 14-Epi-previtamin D3 and 14-Epi-19-nor-previtamin D3 : Their Synthesis and Binding Affinity for Human VDR2012
- Author(s)
  Daisuke Sawada, Tomoyuki Katayama, Yuya Tsukuda, Nozomi Saito, Hiroshi Saito, Shinji Kakuda, Midori Takimoto-Kamimura, Kazuya Takenouchi, and Atsushi Kittaka
- Journal Title
  
  Anticancer Res
  
  Volume : 32 Pages : 319-326
- URL
  http://ar.iiarjournals.org/content/32/1/319.full?sid=d6507568-bc32-4ba6-841c-6b606396458b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] Substitution at carbon 2 of 19-nor-1a, 25-dihydroxyvitamin D_3 with 3-hydroxypropyl group generates an analog with enhanced chemotherapeutic potency in PC-3 prostate cancer cells2011
- Author(s)
  Iglesias-Gato D, Zheng S, Flanagan J. N., Jiang L, Kittaka A, Sakaki T, (他5名)
- Journal Title
  
  J. Steroid. Mol. Biol
  
  Volume : 127 Pages : 269-275
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Mechanism of the Anti-proliferative Action of 25-Hydroxy-19-nor-vitamin D3 in Human Prostate CellsVD_3 action2011
- Author(s)
  Munetsuna E., Kittaka A, Sakaki T.(他8名)
- Journal Title
  
  J Mol Endocrinol
  
  Volume : 47 Pages : 209-218
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 4-substituted chiral PNA monomers2011
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Journal Title
  
  Peptide Science 2010
  
  Volume : 284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099
[Journal Article] ss-PNA: Peptide nucleic acid (PNA) with a chiral center at the ss-position of the PNA backbone2011
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume : 21 Pages : 7317-7320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099
[Journal Article] Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D_3 with 3-hydroxypropyl group generates an analog with enhanced chemotherapeutic potency in PC-3 prostate cancer cells2011
- Author(s)
  Iglesias-Gato D, Kittaka A, Sakaki T, 他8名
- Journal Title
  
  J.Steroid.Mol.Biol.
  
  Volume : 127 Pages : 269-275
- DOI
  10.1016/j.bbadis.2010.07.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Development of 14-epi-19-Nortachysterol and Its Unprecedented Binding Configuration for the Human Vitamin D Receptor2011
- Author(s)
  Sawada D, Kittaka A., 他6名
- Journal Title
  
  J. Am. Chem. Soc
  
  Volume : 133 Pages : 7215-7221
- DOI
  10.1021/ja201481j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067, KAKENHI-PROJECT-21590022
[Journal Article] Novel Vitamin D Analogs for Prostate Cancer Therapy2011
- Author(s)
  Chen TC, Kittaka A
- Journal Title
  
  International Scholarly Research Network(ISRN) Urology
  
  Volume : 32
- DOI
  10.5402/2011/301490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067, KAKENHI-PROJECT-21590022
[Journal Article] New C15-Substituted Active Vitamin D32011
- Author(s)
  Shindo K, Kittaka A., 他12名
- Journal Title
  
  Org. Lett
  
  Volume : 13 Pages : 2852-2855
- DOI
  10.1021/ol200828s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067, KAKENHI-PROJECT-21590022
[Journal Article] 19-Nor-2.-(3-hydroxypropyl)-1., 25-dihydroxyvitamin D3(MART-10) is a Potent Cell Growth Regulator with Enhanced Chemotherapeutic Potency in Liver Cancer Cells2011
- Author(s)
  Chiang KC, Kittaka A., 他7名
- Journal Title
  
  Steroids 2011
  
  Volume : 76 Pages : 1513-1519
- DOI
  10.1016/j.steroids.2011.08.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067, KAKENHI-PROJECT-21590022
[Journal Article] β-PNA : Peptide Nucleic Acid(PNA) with a Chiral Center at the.-Position of the PNA Backbone2011
- Author(s)
  Toru Sugiyama
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume : 21 Pages : 7317-7320
- DOI
  10.1016/j.bmcl.2011.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099, KAKENHI-PROJECT-21590022
[Journal Article] Synthesis of C15-Modified 16-ene-active vitamin D_3 analogs for the receptor-ligand interaction studies2011
- Author(s)
  Atsushi Kittaka, et al
- Journal Title
  
  Anticancer Res.
  
  Volume : 31 Pages : 1500-1501
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] Mechanism of the Anti-proliferative Action of 25-Hydroxy-19-nor-vitamin D_3 in Human Prostate Cells2011
- Author(s)
  Eiji Munetsuna, Sachie Nakabayashi, Rie Kawanami, Kaori Yasuda, Miho Ohta, Midori A. Arai, Atsushi Kittaka, Tai C. Chen, Masaki Kamakura, Shinichi Ikushiro and Toshiyuki Sakaki
- Journal Title
  
  J.Mol.Endocrinol.
  
  Volume : 47 Pages : 209-218
- DOI
  10.1530/jme-11-0008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] Substitution at Carbon 2 of 19-Nor-1α,25-dihydroxyvitamin D_3 with 3-Hydroxypropyl Group Generates an Analog with Enhanced Chemotherapeutic Potency in PC-3 Prostate Cancer Cells2011
- Author(s)
  Diego Iglesias-Gato, Shasha Zheng, John N. Flanagan, Lan Jiang, Atsushi Kittaka, Toshiyuki Sakaki, Keiko Yamamoto, Toshimasa Itoh, Nathan K. LeBrasseur, Gunnar Norstedt, Tai C. Chen
- Journal Title
  
  J.Steroid Biochem.Mol.Biol.
  
  Volume : 127 Pages : 269-275
- DOI
  10.1016/j.jsbmb.2011.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] Synthesis of 4-Substituted Chiral PNA Monomers2011
- Author(s)
  Toru Sugiyama, Yasutaka Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Peptide Science 2010
  
  Volume : 47 Pages : 284-284
- URL
  http://www.prf.or.jp/psb.html
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] Synthesis of C-2 Substituted Vitamin D Derivatives Having Ringed Side Chains and Biological Evaluation, Especially Biological Effect on Bone by Modification at C-2 Position2011
- Author(s)
  Hiroshi Saitoh, Takayuki Chida, Kenichiro Takagi, Kyohei Horie, Yoshiyuki Sawai, Yuko Nakamura, Yoshifumi Harada, Kazuya Takenouchi, and Atsushi Kittaka
- Journal Title
  
  Org. Biomol. Chem
  
  Volume : 9 Pages : 3954-3964
- DOI
  10.1039/c1ob05142c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] CYP105A1二重変異体を発現する放線菌を用いた活性型ビタミンD3の生産2011
- Author(s)
  安田佳織、林恵子、生城真一、鎌倉昌樹、宗綱栄二、杉本宏、城宜嗣、橘高敦史、太田美穂、榊利之
- Journal Title
  
  ビタミン
  
  Volume : 85 Pages : 109-114
- URL
  http://web.kyoto-inet.or.jp/people/vsojkn/journal/index.html
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] CYP105A1二重変異体を発現する放線菌を用いた活性型ビタミンD_3の生産2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之(他6名)
- Journal Title
  
  ビタミン誌
  
  Volume : 82 Pages : 649-661
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 2b-and 2a-Substituted-14-epi-previtamin D_3 and Their Genomic Activity2010
- Author(s)
  Sawada D, Katayama T, Kittaka A, (他7名)
- Journal Title
  
  Tetrahedron
  
  Volume : 66 Pages : 5407-5423
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Facile Synthesis of Stereoisomers of the Non-Secosteroidal Ligand LG190178 and their Evaluation Using the Mutant Vitamin D Receptor2010
- Author(s)
  Demizu Y, Nakatsu A, Kittaka A(他7名)
- Journal Title
  
  Lett. Org. Chem
  
  Volume : 8 Pages : 43-47
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 2a-Substituted-14-epiprevitamin D_3 and Testing of Its Genomic Activity2010
- Author(s)
  Sawada D, Tsukuda Y, Kittaka A, (他6名)
- Journal Title
  
  J. Steroid Biochem. Mol. Biol
  
  Volume : 121 Pages : 20-24
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Studies on the Synthesis and Metabolism of 14-epi-2α-(3-Hydroxypropyl)-19-norvitamin D_3 and Its 2β-Isomer2010
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  Heterocycles
  
  Volume : 82 Pages : 649-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] Sequence-specific cleavage of DNA by peptide nucleic acids conjugated with metal complexes2010
- Author(s)
  Toru Sugiyama, Keiko Ninomiya, Yasutada Imamura, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Journal Title
  
  Peptide Science 2009
  
  Pages : 425-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099
[Journal Article] Three-step hydroxylation of vitamin D_3 by a genetically engineered CYP105A12010
- Author(s)
  Hayashi K, Sugimoto H, Kittaka A, Sakaki T(他6名)
- Journal Title
  
  FEBS J
  
  Volume : 277 Pages : 3999-4009
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Studies on Synthesis and Metabolism of 14-epi-2a-(3-Hydroxy propyl)-19-norvitamin D_3 and its 2a-isomer2010
- Author(s)
  Kittaka A, Hara H, Yasuda K, Sakaki T(他6名)
- Journal Title
  
  Heterocycles
  
  Volume : 82 Pages : 649-661
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Three-step hydroxylation of vitamin D_3 by a genetically engineered CYP 105A12010
- Author(s)
  Hayashi K, Sugimoto H, Kittaka A, Sakaki T, 他6名
- Journal Title
  
  FEBS J
  
  Volume : 277 Pages : 3999-4009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Studies on Synthesis and Metabolism of 14-epi-2a-(3-Hydroxypropyl) -19-norvitamin D_3 and its 2a-isomer2010
- Author(s)
  Kittaka A, Hara H, Yasuda K, Sakaki T, 他6名
- Journal Title
  
  Heterocycles
  
  Volume : 82 Pages : 649-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 2β-Substituted-14-epi-previtamin D_3 and Testing of Its Genomic Activity2010
- Author(s)
  Sawada D, Tsukuda Y, Kittaka A, 他6名
- Journal Title
  
  J.Steroid Biochem.Mol.Biol.
  
  Volume : 121 Pages : 20-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Sequence-specific cleavage of DNA by peptide nucleic acids conjugated with metal complexes2010
- Author(s)
  T.Sugiyama, K.Ninomiya, Y.Imamura, M.Kurihara, M.Takano, A.Kittaka
- Journal Title
  
  Peptide Science 2009
  
  Pages : 425-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099
[Journal Article] Synthesis of 2β- and 2α-Substituted-14-epi-previtamin D_3 and Their Genomic Activity2010
- Author(s)
  Sawada D, Katayama T, Kittaka A, 他7名
- Journal Title
  
  Tetrahedron
  
  Volume : 66 Pages : 5407-5423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Facile Synthesis of Stereoisomers of the Non-Secosteroidal Ligand LG190178 and their Evaluation Using the Mutant Vitamin D Receptor2010
- Author(s)
  Demizu Y, Nakatsu A, Kittaka A , 他7名
- Journal Title
  
  Lett.Org.Chem
  
  Volume : 8 Pages : 43-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] CYP 105A1二重変異体を発現する放線菌を用いた活性型ビタミンD_3の生産2010
- Author(s)
  安田佳織、杉本宏、橘高敦史, 榊利之, 他6名
- Journal Title
  
  ビタミン誌
  
  Volume : 82 Pages : 649-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis and Biological Evaluation of 4-Substituted Vitamin D and 14-Epi-Previtamin D Analogs2009
- Author(s)
  Sawada D, Yuya Tsukuda, Kittaka A., 他5名
- Journal Title
  
  Chem.Pharm.Bull. 57
  
  Pages : 1431-1433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Cooperative strand Kurihara, Atsushi Kittaka2009
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Masaaki Kurihara, Atsushi Kittaka
- Journal Title
  
  Cooperative strand 2008
  
  Pages : 481-482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099
[Journal Article] Evaluation of 19-nor-2a-(3-hydroxyl propyl)-1a, 25-dihydroxyvitamin D_3 As a Therapeutic Agent for Androgendependent Prostate Cance2009
- Author(s)
  Flanagan JN, Zheng S, Kittaka A, Sakaki T, (他10名)
- Journal Title
  
  Anticancer Res
  
  Volume : 29 Pages : 3547-3553
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] 14-epi-MART-10 and 14-epi-MART-11 with Antiproliferative and Cell Differentiation2009
- Author(s)
  Kittaka A, Hara H, Takano M, Sakaki T(他13名)
- Journal Title
  
  Anticancer Res
  
  Volume : 29 Pages : 3563-3569
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of a 1alpha-C-Methyl Analogue of 25-Hydroxyvitamin D_3 : Interaction with a Mutant Vitamin D Receptor Arg274Leu2009
- Author(s)
  Honzawa S, Takahashi N, Kittaka A, (他5名)
- Journal Title
  
  Tetrahedron
  
  Volume : 65 Pages : 7135-7145
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 2a-Propoxy-1α, 25-dihydroxyvitamin D_3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A12009
- Author(s)
  Saito N, Suhara Y, Sakaki T, Kittaka A(他3名)
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 19 Pages : 5640-5643
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis and Biological Evaluation of 4-Substituted Vitamin D and 14-Epi-Previtamin D Analogs2009
- Author(s)
  Sawada D, Yuya Tsukuda, Kittaka A.(他5名)
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume : 57 Pages : 1431-1433
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 2α-substituted-14-epiprevitamin D_3 and its genomic activity2009
- Author(s)
  Sawada D, Katayama T, Kittaka A, (他9名)
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume : 19 Pages : 5397-5400
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Cooperative strand invasion by peptide nucleic acid2009
- Author(s)
  T.Sugiyama, Y.Imamura, M.Kurihara, A.Kittaka
- Journal Title
  
  Peptide Science 2008
  
  Pages : 481-482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590099
[Journal Article] TEI-9647 とTEI-9648 の構造活性相関研究 ; 2α位と24 位の化学修飾~最強のVDR アンタゴニスト活性を目指して~2009
- Author(s)
  橘高敦史、齋藤望、竹之内一弥、石塚誠一
- Journal Title
  
  ビタミン 83巻(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Synthesis of 2alpha-substituted-14-epi-previtamin D_3 and its genomic activity2009
- Author(s)
  Sawada D, Katayama T, Kittaka A, 他9名
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages : 5397-5400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of a 1alpha-C-Methyl Analogue of 25-Hydroxyvitamin D_3 : Interaction with a Mutant Vitamin D Receptor Arg274Leu"2009
- Author(s)
  Honzawa S, Takahashi N, Kittaka A, 他5名
- Journal Title
  
  Tetrahedron 65
  
  Pages : 7135-7145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 2α-Propoxy-1α, 25-dihydroxyvitamin D_3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A12009
- Author(s)
  Saito N, Suhara Y, Sakaki T, Kittaka A, 他3名
- Journal Title
  
  Bioorganic & Medicinal Chemistry 17
  
  Pages : 4296-4301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Evaluation of 19-nor-2α-(3-hydroxypropyl)-1α, 25-dihydroxyvitamin D_3 As a Therapeutic Agent for Androgen-dependent Prostate Cancer2009
- Author(s)
  Flanagan JN, Zheng S, Kittaka A, Sakaki T, 他10名
- Journal Title
  
  Anticancer Res. 29
  
  Pages : 3547-3553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] 14-epi-MART-10 and 14-epi-MART-11 with Antiproliferative and Cell Differentiation : Synthesis and Biological Evaluations2009
- Author(s)
  Kittaka A, Hara H, Takano M, Sakaki T, 他13名
- Journal Title
  
  Anticancer Res. 29
  
  Pages : 3563-3569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis and Biological Activities of 14-epi-MART-10 and 14-epi-MART-11 : Implications for Cancer and Osteoporosis Treatment2009
- Author(s)
  Atsushi Kittaka
- Journal Title
  
  Anticancer Res. 29(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] TEI-9647とTEI-9648の構造活性相関研究 : 2α位と24位の化学修飾〜最強のVDRアンタゴニスト活性を目指して〜2009
- Author(s)
  橘高敦史
- Journal Title
  
  ビタミン 83(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] TEI-9647とTEI-9648の構造活性相関研究:2α位と24位の化学修飾～最強のVDRアンタゴニスト活性を目指して～2009
- Author(s)
  橘高敦史, ら
- Journal Title
  
  ビタミン 83
  
  Pages : 569-579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] Synthesis and Biological Activities of 14-eprMART-10 and 14-epi-MART-11: Implications for Cancer and Osteoporosis Treatment2009
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  Anticancer Res. 29
  
  Pages : 3563-3569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590022
[Journal Article] Seco-ステロイド骨格の構造展開と核内受容体を介する生物活性2008
- Author(s)
  橘高敦史
- Journal Title
  
  薬学雑誌2008 128
  
  Pages : 1235-1250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] The 2α-(3-hydroxypropyl) group as an active motif in vitamin D_3 analogues as agonists of the mutant vitamin Dreceptor (Arg274Leu)2008
- Author(s)
  Shinobu Honzawa, Yasuhiro Yamamoto, Atsushi Yamashita, Takayuki Sugiura, Masaaki Kurihara, Midori M. Arai, Shigeaki Kato, Atsushi Kittaka
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages : 3002-3024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] (2 S,2' R)-Analogue of LG190178 Is a Major Active Isomer2008
- Author(s)
  Wataru Hakamata, Yukiko Sato, Haruhiro Okuda, Shinobu Honzawa, Nozomi Saito, Seishi Kishimoto, Atsushi Yamashita, Takayuki Sugiura, Atsushi Kittaka, Masaaki Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett 18
  
  Pages : 120-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Seco-ステロイド骨格の構造展開と核内受容体を介する生物活性2008
- Author(s)
  橘高敦史
- Journal Title
  
  薬学雑誌 128
  
  Pages : 1235-1250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Vitamin D Hormone : Structural Refinement of the seco-Steroidal Skeleton and the Nucle Biological Activity2008
- Author(s)
  At sushi Kittaka
- Journal Title
  
  Anticancer Res. 28
  
  Pages : 1618-1619
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] High-Throughput System for Analyzing Ligand-Induced Cofactor Recruitment by Vitamin D Receptor2007
- Author(s)
  Midori A.Arai, Ken-ichi Takeyama, Saya Ito, Shigeaki Kato, Tai C.Chen, Atsushi Kittaka
- Journal Title
  
  Bioconjugate Chem
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Creative Synthesis of Novel Vitamin D Analogs for Health and Disease2007
- Author(s)
  Atsushi Kittaka, Nozomi Saito, Sinobu Honzawa, Kazuya Takenouchi, Seiichi Ishizuka, Tai C. Chen, Sara Peleg, Sigeaki Kato Midori A. Arai
- Journal Title
  
  J. Steroid Biochem. Mol. Biol. 103
  
  Pages : 269-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Creative Synthesis of Novel Vitamin D Analogs for Health and Disease2007
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Recognition of Longer Duplex DNA by Cooperative Strand Invasion2007
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Masaaki Kurihara, Atsushi Kittaka
- Journal Title
  
  Nucleic Acids Symp. Ser. No. 51
  
  Pages : 269-270
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] ビタミンD_3-26,23-ラクトンを基盤とするビタミンD受容体アンタゴニストの設計と合成2007
- Author(s)
  齋藤望、橘高敦史
- Journal Title
  
  有機合成化学協会誌 65
  
  Pages : 947-958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Kinetic Studies of 25-Hydroxy-19-Nor-Vitamin D_3 and 1α,25-Dihydroxy-19-Nor-Vitamin D_3 Hydroxylation by CYP27B1 and CYP24A12007
- Author(s)
  Naoko Urushino, Sachie Nakabayashi, Midori A. Arai, Atsushi Kittaka, Tai C. Chen, Keiko Yamamoto, Keiko Hayashi, Shigeaki Kato, Miho Ohta, Masaki Kamakura, Shinichi Ikushiro, Toshiyuki Sakaki
- Journal Title
  
  Drug Metab. Dispos. 35
  
  Pages : 1482-1488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] High-Throughput System for Analyzing Ligand-Induced Cofactor Recruitment by Vitamin D Receptor2007
- Author(s)
  Midori A. Arai, Ken-ichi Takeyama, Saya Ito, Shigeaki Kato, Tai C. Chen, Atsushi Kittaka
- Journal Title
  
  Bioconjugate Chem. 18
  
  Pages : 614-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Evaluation of C-2-Substituted 19-Nor-1α,25-dihydroxyvitamin D_3 Analogs as Therapeutic Agents for Prostate Cancer2007
- Author(s)
  Tai C. Chen, Kelly S. Persons, Shasha Zheng, Jeffrey Mathieu, Michael F. Holick, Y. F. Lee, B. Bao, Midori A. Arai, Atsushi Kittaka
- Journal Title
  
  J. Steroid Biochem. Mol. Biol. 103
  
  Pages : 717-720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Creative Synthesis of Novel Vitamin D Analogs for Health and Disease2007
- Author(s)
  Atsushi Kittaka, Nozomi Saito, Sinobu Honzawa, Kazuya Takenouchi, Seiichi Ishizuka, Tai C. Chen, Sara Peleg, Sigeaki Kato, Midori A. Arai
- Journal Title
  
  J. Steroid Biochem. Mol. Biol. doi:10.1016/j.jsbmb.2006.12.002
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Synthesis and Biological Evaluation of Several Structural Analogs of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand2007
- Author(s)
  Yoshitomo Suhara, Saori Oka, Atsushi Kittaka, Hiroaki Takayama, Keizo Waku, Takayuki Sugiura
- Journal Title
  
  Bioorg. Med. Chem. 15(2)
  
  Pages : 854-867
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Creative Synthesis of Novel Vitamin D Analogs for Health and Disease2007
- Author(s)
  Atsushi Kittaka, et. al.
- Journal Title
  
  J. Steroid Biochem. Mol. Biol 103
  
  Pages : 269-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] アポ型とポロ型2007
- Author(s)
  橘高敦史, ら
- Journal Title
  
  有機合成化学協会誌 65
  
  Pages : 1011-1011
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Evaluation of C-2-Substituted 19-Nor-1α, 25-dihydroxy- vitamin D_3 Analogs as Therapeutic Agents for Prostate Cancer2007
- Author(s)
  Tai C.Chen, K.S.Persons, S.Zheng, J.Mathieu, M.F.Holick, Y.F.Lee, B.Bao, Midori A.Arai, Atsushi Kittaka
- Journal Title
  
  J. Steroid Biochem. Mol. Biol. doi:10.1016/j.jsbmb.2006.12.009
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Recent Progress of Study on Vitamin D Analogs2006
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  Clinical Calcium 16・7
  
  Pages : 1154-1165
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] ビタミンD受容体(VDR)モジュレーターと新たな評価系の開発2006
- Author(s)
  橘高敦史
- Journal Title
  
  上原記念生命科学財団研究報告集 20
  
  Pages : 16-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] ビタミンD受容体(VDR)モジュレ-タ-と新たな評価系の開発2006
- Author(s)
  橘高敦史
- Journal Title
  
  上原記念生命科学財団研究報告集 20
  
  Pages : 16-19
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Further Synthetic and Biological Studies on Vitamin D Hormone Antagonists Based on C24-Alkylation and C2α-Functionalization of 25-Dehydro-1α-hydroxyvitamin D_3-26, 23-lactones2006
- Author(s)
  Nozomi Saito, Toshihiro Matsunaga, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, Jun-ichi Namekawa, Seiichi Ishizuka, Atsushi Kittaka
- Journal Title
  
  J. Med. Chem. 49 (24)
  
  Pages : 7063-7075
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Highly Potent Vitamin D Antagonists : Design, Synthesis and Biological Evaluation"2006
- Author(s)
  Nozomi Saito, Atsushi Kittaka
- Journal Title
  
  Chem Bio Chem 7(10)
  
  Pages : 1478-1490
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Efficient Synthesis of Carbopeptoid Oligomers : Insight into Mimicry of β-Peptide2006
- Author(s)
  Yoshitomo Suhara, Masaaki Kurihara, Atsushi Kittaka, Yoshitaka Ichikawa
- Journal Title
  
  Tetrahedron 62(34)
  
  Pages : 8207-8217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Probing a Water Channel near the A-Ring of Receptor- Bound 1α, 25-Dihydroxyvitamin D_3 with Selected 2α- Substituted Analogues2006
- Author(s)
  Shinji Hourai, Toshie Fujishima, Atsushi Kittaka, Yoshitomo Suhara, Hiroaki Takayama, Natacha Rochel, Dino Moras
- Journal Title
  
  J. Med. Chem 49 (17)
  
  Pages : 5199-5205
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Biological Activities of 2α-Substituted Analogues of 1α, 25-Dihydroxyvitamin D_3 in Transcriptional Regulation and Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation2006
- Author(s)
  Eiji Takahashi, Kimie Nakagawa, Yoshitomo Suhara, Atsushi Kittaka, Ken-ichi Nihei, Katsuhiro Konno, Hiroaki Takayama, Keiichi Ozono, Toshio Okano
- Journal Title
  
  Biol. Pharm. Bull. 29(11)
  
  Pages : 2246-2250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Sequence-specific Recognition of Double-Stranded DNA by Cooperative Strand Invasion2006
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Wataru Hakamata, Masaaki Kurihara, Atsushi Kittaka
- Journal Title
  
  Nucleic Acids Symp. Ser. (No. 50)
  
  Pages : 157-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Recent Progress of Study on Vitamin D Analogs2006
- Author(s)
  Atsushi Kittaka, Nozomi Saito, Masashi Takano
- Journal Title
  
  Clinical Calcium 16 (7)
  
  Pages : 1154-1165
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Methyl-introduced A-ring Analogues of 1α,25- Dihydroxyvitamin D_3 : Synthesis and Biological Evaluation2006
- Author(s)
  Toshie Fujishima, Ryuji Tsutsumi, Yoichi Negishi, Shinya Fujii, Hiroaki Takayama, Atsushi Kittaka, Masaaki Kurihara
- Journal Title
  
  Anticancer Research 26 (4)
  
  Pages : 2633-2636
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Novel 2-Alkyl-1α, 25-dihydroxy-19-norvitamin D_3 : Efficient Synthesis with Julia Olefination, Evaluation of Biological Activity, and Development of New Analyzing System for Co-activator Recruitment2006
- Author(s)
  Midori A.Arai, Atsushi Kittaka
- Journal Title
  
  Anticancer Research 26 (4)
  
  Pages : 2621-2632
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Recent Results on A-Ring Modification of 1α, 25- Dihydroxyvitamin D_3 : Design and Synthesis of VDR-Agonists and Antagonists with High Biological Activity2006
- Author(s)
  Nozomi Saito, Shinobu Honzawa, Atsushi Kittaka
- Journal Title
  
  Current Topics in Medicinal Chemistry 6(12)
  
  Pages : 1273-1288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Synthesis and 2α-Modification of 24-Phenylvitamin D_3 Lactones : Effects on VDR Antagonistic Activity2006
- Author(s)
  Nozomi Saito, Toshihiro Matsunaga, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, Seiichi Ishizuka, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Heterocycles 67(1)
  
  Pages : 311-336
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Efficient Synthesis of 2-Alkylated 1α,25-Dihydroxy-19-norvitamin D_3 with Julia Olefination and Its Biological Activity2005
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  Anticancer Research 25
  
  Pages : 2288-2288
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Metabolism of 2α-Propoxy-lα, 25-dihydroxyvitamin D_3 and 2a-(3-Hydroxypropoxy)-1α, 25-dihydroxyvitamin D_3 by Human CYP27A1 and CYP24A12005
- Author(s)
  Daisuke Abe, Toshiyuki Sakaki, Tatsuya Kusudo, Atsushi Kittaka, Nozomi Saito, Yoshitomo Suhara, Toshie Fujishima, Hiroaki Takayama, Hiromi Hamamoto, Masaki Kamakura, Miho Ohta, Kuniyo Inouye
- Journal Title
  
  Drug Metabolism and Disposition 33 (6)
  
  Pages : 778-784
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Efficient Synthesis of 2-Alkylated 1α, 25-Dihydroxy-19-norvitamin D_3 with Julia Olefination and Its Biological Activity2005
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  Anticancer Research 25
  
  Pages : 2288-2288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Design, Synthesis and Biological Activity of Less Calcemic, Prohormone- and Hormone-like 19-Norvitamin D_3 Analogs for Prostate Cancer Treatment2005
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  Journal of Bone and Mineral Research. Suppl. 1 20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] The Antagonizm between 2-Methyl-1, 25-dihydroxyvitamin D_3 and 2-Methyl-20-epi-1, 25-dihydroxyvitamin D_3 in Non-genomic Pathway-mediated Biological Responses Induced by lα, 25-Dihydroxyvitamin D_3 Assessed by NB4 Cell Differentiation2005
- Author(s)
  Daishiro Miura, Anthony W.Norman, Mathew T.Mizwicky, Toshie Fujishima, Katsuhiro Konno, Atsushi Kittaka, Hiroaki Takayama, Seiichi Ishizuka
- Journal Title
  
  J Steroid Biochem. Ma. Biol. 94 (5)
  
  Pages : 469-479
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Design and Synthesis of 19-Norvitamin D_3 Analogs as Prostate Cancer Chemoprevention Agents : Less Calcemic and Prohormone Like Activity2005
- Author(s)
  Midori A.Arai, Ryuji Tsutsumi, Tai C.Chen, Michael F.Holick, Toshiyuki Sakaki, Naoko Urushino, Kuniyo Inoue, Atsushi Kittaka
- Journal Title
  
  Anticancer Research 25
  
  Pages : 2278-2278
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Synthesis of 25-Hydoxy-19-norvitamin D_3 Analogs and Their Antiproliferative Activities on Prostate Cells2005
- Author(s)
  Midori A.Arai, Ryuji Tsutsumi, Hideki Hara, Tai C.Chen, Toshiyuki Sakaki, Naoko Urushino, Kuniyo Inouye, Atsushi Kittaka
- Journal Title
  
  Heterocycles 66 (1)
  
  Pages : 469-479
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Cooperative Strand Invasion of Double-Stranded DNA by Peptide Nucleic Acid2005
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Wataru Hakamata, Masaaki Kurihara, Atsushi Kittaka
- Journal Title
  
  Nucleic Acids Symp. Ser. (No. 49)
  
  Pages : 167-168
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Novel 2, 2-Functionalized Analogues of 1α, 25- Dihydroxyvitamin D_3 : Synthesis, Biological Evaluation and Their Possible Binding Modes to Vitamin D Receptor2005
- Author(s)
  Toshie Fujishima, Ryuji Tsutsumi, Yoichi Negishi, Hiroaki Takayama, Atsushi Kittaka, Masaaki Kurihara
- Journal Title
  
  Anticancer Research 25
  
  Pages : 2285-2285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Design, Synthesis and Biological Activity of Less Calcemic, Prohormone- and Hormone-like 19-Norvitamin D_3 Analogs for Prostate Cancer Treatment2005
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  J.Bone Miner.Res.Suppl.1 20
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Synthesis of 24, 24-Ethanovitamin D_3 Lactones Using Ruthenium-Catalyzed Intermolecular Enyne Metathesis : Potent Vitamin D Receptor Antagonists2005
- Author(s)
  Nozomi Saito, Manami Masuda, Hiroshi Saito, Kazuya Takenouchi, Ishizuka Seiichi, Jun-ichi Namekawa, Midori Takimoto-Kamimura, Atsushi Kittaka
- Journal Title
  
  Synthesis (15)
  
  Pages : 2533-2543
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Design, Synthesis and Biological Evaluation of Novel lα, 25-Dihydroxyvitamin D_3 Analogues Possessing Aromatic Ring on 2α-Position2005
- Author(s)
  Shinobu Honzawa, Koshiro Hirasaka, Yasuhiro Yamamoto, Salα Peleg, Toshie Fujishima, Masaaki Kurihara, Nozomi Saito, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Tetrahedron 61 (47)
  
  Pages : 11253-11263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Efficient Synthesis of 2-Alkylated 1α, 25-Dihydroxy- 19-norvitamin D_3 with Julia Olefination and Its Biological Activity2005
- Author(s)
  Atsushi Kittaka, Keiichiro Ono, Nozomi Saito, Akihiro Yoshida, Shinobu Honzawa, Toshie Fujishima, Hiroaki Takayama, Midori A. Arai, Tai C. Chen
- Journal Title
  
  Anticancer Research 25
  
  Pages : 2288-2288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Schiff Bade Formation Between 5-Formly1-2'-deoxyuridine and lysine ε-Amino Group at Monomer and Oligomer Levels2004
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  Heterocycles 64巻
  
  Pages : 367-382
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Seco-ステロイド骨格A環と側鎖の新たな構造修飾:ビタミンD受容体のアゴニストからアンタゴニストまで2004
- Author(s)
  橘高敦史
- Journal Title
  
  ビタミン 78巻・10号
  
  Pages : 528-529
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Topological Stabilization of PNA-DNA Invasion Complex2004
- Author(s)
  Toru Sugiyama, Reiko Kuroda, Atsushi Kittaka
- Journal Title
  
  Nucleic Acids Symp. (No. 48)
  
  Pages : 39-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-lα, 25-dihydroxyvitamin D_3 Including 2-epi-ED-71 and Its 20-Epimers with HL-60 Cell Differentiation Activity2004
- Author(s)
  Nozomi Saito, Yoshitomo Suhara, Masaaki Kurihara, Toshie Fujishima, Shinobu Honzawa, Hitoshi Takayanagi, Toshiro Kozono, Masahiko Matsumoto, Masayuki Ohmori, Naoki Miyata, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  J Org.Chem. 69(22)
  
  Pages : 7463-7471
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Schiff Base Formation Between 5-Formyl-2'-deoxyuridine and Lysine ε-Amino Group at Monomer and Oligomer Levels2004
- Author(s)
  Atsushi Kittaka, Chikafumi Horii, Hiromichi Tanaka, Tadashi Miyasaka, Kazuo T.Nakamura, Reiko Kuroda, Toru Sugiyama
- Journal Title
  
  Heterocycles 64
  
  Pages : 367-382
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Schiff Base Formation Between 5-Formyl-2'-deoxyuridine and Lysine ε-Amino Group at Monomer and Oligomer Levels2004
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  Heterocycles 64巻
  
  Pages : 367-382
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of Novel 1α, 25-Dihydroxy-19-norvitamin D_3 with an Amide Conjugate2004
- Author(s)
  Yoshitomo Suhara, Keiichiro Ono, Akihiro Yoshida, Toshie Fujishima, Nozomi Saito, Shinobu Honzawa, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Heterocycles 62(1)
  
  Pages : 423-436
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] 2,2-Functionalized Analogues of 1α, 25-Dihydroxyvitamin D_3, The Potent Inducers of Cell Differentiation2004
- Author(s)
  Toshie Fujishima, Atsushi Kittaka, Masaaki Kurihara, Nozomi Saito, Shinobu Honzawa, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 89-90 (May)
  
  Pages : 89-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of PNA Using a Fmoc/Boc Protecting Group Strategy2004
- Author(s)
  Toru Sugiyama, Atsushi Kittaka, Yohei Takemoto, Reiko Kuroda
- Journal Title
  
  Peptide Science 2003
  
  Pages : 447-448
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] 24, 24-Dimethylvitamin D_3-26, 23-lactones and Their 2α-Functionalized Analogues as Highly Potent VDR Antagonists2004
- Author(s)
  Nozomi Saito, Manami Masuda, Toshihiro Matsunaga, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, Seiichi Ishizuka, Midori Kamimura, Atsushi Kittaka
- Journal Title
  
  Tetrahedron 60 (36)
  
  Pages : 7951-7961
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Metabolism of A-Ring Diastereomers of 1α, 25-Dihydroxyvitamin D_3 by CYP24A12004
- Author(s)
  Tatsuya Kusudo, Toshiyuki Sakaki, Daisuke Abe, Toshie Fujishima, Atsushi Kittaka, Hiroaki Takayama, Susumi Hatakeyama, Miho Ohta, Kuniyo Inouye
- Journal Title
  
  Biochem.Biophys.Res.Commun 321 (4)
  
  Pages : 774-782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of 2,2-Dimethyl-1,25-dihydroxyvitamin D_3 : A-Ring Structural Motif that Modulates Interactions of Vitamin D Receptor with Transcriptional Coactivators2003
- Author(s)
  Toshie Fujishima, Atsushi Kittaka, Kazuyoshi Yamaoka, Ken-ichi Takeyama, Shigeaki Kato, Hiroaki Takayama
- Journal Title
  
  Org.Biomol.Chem. 1(11)
  
  Pages : 1863-1869
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Drug action at receptors (translation)2003
- Author(s)
  Atushi Kittaka
- Journal Title
  
  Medicinal Chemistry (Maruzen, Tokyo)
  
  Pages : 64-90
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Design, Synthesis, and Biological Studies of the A-Ring Modified 1,25-Dihydroxyvitamin D_3 Analogs2003
- Author(s)
  Hiroaki Takayama, Atsushi Kittaka, Toshie Fujishima, Yoshitomo Suhara
- Journal Title
  
  Recent Results in Cancer Research Vol. 164, Vitamin D analogs in cancer prevention and therapy (Reichrath J.,Fridrich M.,Tilgen W.Eds.) (Springer-Verlag : Berlin Heidelberg, Germany)
  
  Pages : 289-317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Concise Synthesis and Biological Activities of 2α-Alkyl-and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-Dihydroxyvitamin D_32003
- Author(s)
  Shinobu Honzawa, Yoshitomo Suhara, Ken-ichi Nihei, Nozomi Saito, Seishi Kishimoto, Toshie Fujishima, Masaaki Kurihara, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Bioorg.Med.Chem.Lett. 13(20)
  
  Pages : 3503-3506
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Aggregation of RecA-Derived Peptides on Single-Stranded Oligonucleotides Triggered by Schiff Base-Mediated Crosslinking2003
- Author(s)
  Toru Sugiyama, Atsushi Kittaka, Hiroaki Takayama, Mitsugu Tomioka, Yoshiteru Ida, Reiko Kuroda
- Journal Title
  
  Bioorg.Med.Chem.Lett. 13(17)
  
  Pages : 2847-2851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Design and Synthesis of Potent Vitamin D Receptor Antagonists with A-Ring Modifications : Remarkable Effects of 2α-Methyl Introduction on Antagonistic Activity2003
- Author(s)
  Toshie Fujishima, Yoshinori Kojima, Isao Azumaya, Atsushi Kittaka, Hiroaki Takayama
- Journal Title
  
  Bioorg.Med.Chem. 11(17)
  
  Pages : 3621-3631
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Efficient and Convergent Coupling Rouye for the Short-step Synthesis of Enantio-pure 2α- and 2β-Alkylated 1α,25-Dihydroxy-19^nor-vitamin D_3 Analogues2003
- Author(s)
  Akihiro Yoshida, Keiichiro Ono, Yoshitomo Suhara, Nozomi Saito, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Synlett (8)
  
  Pages : 1175-1179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of an A-Ring Synthon of 2α-Substituted Vitamin D_3 Analogues Utilizing Grignard Reaction Towards Methyl 2,3-Anhydro-4,6-O-benzylidene-α-D-mannopyranoside2003
- Author(s)
  Shinobu Honzawa, Yasuhiro Yamamoto, Koshiro Hirasaka, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Heterocycles 61
  
  Pages : 327-338
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Remarkable Effect of 2α-Modification on the VDR Antagonistic Activity of 1α-Hydroxyvitamin D_3-26,23-Lactones2003
- Author(s)
  Nozomi Saito, Toshihiro Matsunaga, Toshie Fujishima, Miyuki Anzai, Hiroshi Saito, Kazuya Takenouchi, Daishiro Miura, Seiichi Ishizuka, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Org.Biomol.Chem. 1(24)
  
  Pages : 4396-4402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Dramatic Enhancement of Antagonistic Activity on Vitamin D Receptor : A Double Functionalization of 1α-Hydroxyvitamin D3-26,23-Lactones2003
- Author(s)
  Nozomi Saito, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, Seiichi Ishizuka, Toshie Fujishima, Akihiro Yoshida, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  Org.Lett. 5 (25)
  
  Pages : 4859-4862
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis of 2-Modified 1α,25-Dihydroxy-19-norvitamin D_3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells2003
- Author(s)
  Keiichiro Ono, Akihiro Yoshida, Nozomi Saito, Toshie Fujishima, Shinobu Honzawa, Yoshitomo Suhara, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka
- Journal Title
  
  J.Org.Chem. 68(19)
  
  Pages : 7407-7415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Metabolism of 20-Epimer of 1α,25-Dihydroxyvitamin D_3 by CYP24 : Species-based Difference between Humans and Rats2003
- Author(s)
  Tatsuya Kusudo, Toshiyuki Sakaki, Abe Daisuke, Toshie Fujishima, Atsushi Kittaka, Hiroaki Takayama, Miho Ohta, Kuniyo Inoue
- Journal Title
  
  Biochem.Biophys.Res.Commun. 309(4)
  
  Pages : 885-892
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590021
[Journal Article] Synthesis and Biologica Activities of 14- epi-MART-10 and 14- epi-MART-11 : Implications for Cancer and Osteoporosis Treatment
- Author(s)
  Atsushi Kittaka, Hideki Hara, Masashi Takano, Daisuke Sawada, Midori A. Arai, Kenichiro Takagi, Takayuki Chida, Yoshifumi Harada, Hiroshi Saito, Kazuya Takenouchi, Seiichi Ishizuka, Keiko Hayashi, Shinichi Ikushiro, Toshiyuki Sakaki, Takayuki Sugiura, Tai C. Chen
- Journal Title
  
  Anticancer Res.(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Evaluation of 19-nor-2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D_3 As a Therapeutic Agent for Androgen-dependent Prostate Cancer
- Author(s)
  John N. Flanagan, Shasha Zheng, Kun-Chun Chiang, Atsushi Kittaka, Toshiyuki Sakaki, Sachie akabayashi, Remco A. Spanjaard, Kelly S. Persons, Jeffrey S. athieu, Michael F. Holick, Tai C. Chen
- Journal Title
  
  Anticancer Res.(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590016
[Journal Article] Creative Synthesis of Novel Vitamin D Analogs for Health and Disease
- Author(s)
  Atsushi Kittaka, et al.
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology in press
- Data Source
  KAKENHI-PROJECT-17590012
[Journal Article] Design, Synthesis and Biological Activity of Less Calcemic, Prohormone-and Hormone-like 19-Norvitamin D_3 Analogs for Prostate Cancer Treatment
- Author(s)
  Atsushi Kittaka, Midori A.Arai, Ryuji Tsutsumi, Toshiyuki Sakaki, Naoko Urushino, Kuniyo Inouye, Saya Ito, Ken-ichi Takeyama, Shigeaki Kato, Michael F.Holick, Tai C.Chen
- Journal Title
  
  J Bone Miner. Res. Suppl 12005
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590012
[Presentation] 14-エピ-19-ノルタキステロールの8,9-ジヒドロ化と高いビタミンD活性2018
- Author(s)
  川越文裕、澤田大介、竹内明子、上杉志成、橘高敦史
- Organizer
  日本薬学会第138年会（金沢　もてなしドーム）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] グアニンPNAモノマーの新規カチオン性アナログ2018
- Author(s)
  杉山　亨、小原美咲、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史
- Organizer
  日本薬学会第138年会（金沢　もてなしドーム）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 再生医療を指向したβ-アミノ酸を含む新規コラーゲン模倣物の創製2018
- Author(s)
  下田茜、伊東未祐、上村光、杉山亨、橘高敦史、須原義智
- Organizer
  日本薬学会第138年会（金沢　もてなしドーム）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2-[2-(テトラゾール-2-イル)エチル]-1α,25(OH)2-19-ノルビタミンD3の合成2018
- Author(s)
  高野真史，橘高敦史
- Organizer
  日本薬学会第138年会（金沢　もてなしドーム）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] SYNTHESIS OF FALECALCITRIOL DERIVATIVES USING CF3TMS AS A TRIFLUOROMETHYLATION REAGENT2017
- Author(s)
  F. Kawagoe, T. Sugiyama, M. Uesugi, A. Kittaka
- Organizer
  20th Vitamin D Workshop
- Place of Presentation
  Rosen Hotel, Orland, USA
- Year and Date
  2017-03-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ビタミンD誘導体AH-1のCYP24A1代謝物24位エピマーの合成2017
- Author(s)
  高野真史，安田佳織，真野寛生，遠山枝李，榊　利之，橘高敦史
- Organizer
  日本ビタミン学会第69回大会(横浜市開港記念会館）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 電荷を帯びたグアニンアナログをもつPNAの合成2017
- Author(s)
  杉山亨、小原美咲、栗原正明、橘高敦史
- Organizer
  第61回日本薬学会関東支部大会（慶應義塾大学薬学部）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2位置換基上にアゾールを有するビタミンD3誘導体の合成2017
- Author(s)
  高野真史，安田佳織，榊　利之，橘高敦史
- Organizer
  第3回 Neo Vitamin D Workshop 学術集会（海運倶楽部）
- Invited
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 効率的ファレカルシトリオール側鎖構造の構築2017
- Author(s)
  川越文裕、杉山亨、上杉志成、橘高敦史
- Organizer
  日本ビタミン学会第69回大会(横浜市開港記念会館）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 高感度かつ短時間にビタミンD誘導体のVDR親和性を評価するシステムの開発2017
- Author(s)
  真野寛生、生城真一、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第69回大会(横浜市開港記念会館）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 正電荷を帯びたグアニン誘導体をもつPNAの合成2017
- Author(s)
  杉山　亨,　小原美咲,　桑田啓子,　今村保忠,　出水庸介,　栗原正明,　橘高敦史
- Organizer
  第35回メディシナルケミストリーシンポジウム（名古屋大学）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ビタミンD誘導体AH-1のCYP24A1代謝物24位エピマーの合成2017
- Author(s)
  高野真史・安田佳織真野寛生・遠山枝李榊利之・橘高敦史
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] FMO calculations on specific interactions between vitamin-D receptor and its ligands2017
- Author(s)
  Ryosuke Takeda, Ittetsu Kobayashi, Kanako Shimamura, Hiromi Ishimura, Ryushi Kadoya, Kentaro Kawai, Atsushi Kittaka, Midori Takimoto-Kamimura, Noriyuki Kurita
- Organizer
  CBI学会2017年大会（タワーホール船堀）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] (24S)-2α-[2-(テトラゾール-2-イル)エチル]-1α,24,25-トリヒドロキシビタミンD3の合成2017
- Author(s)
  高野真史・安田佳織真野寛生・遠山枝李榊利之・橘高敦史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] アゾール基を有するビタミンＤ誘導体のCYP24A1による代謝2017
- Author(s)
  遠山枝李・安田佳織真野寛生・鎌倉昌樹生城真一・高野真史橘高敦史・太田美穂榊利之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] SYNTHETIC STUDIES ON VITAMIN D DERIVATIVES WITH LACTONE SIDE CHAIN2017
- Author(s)
  A. Nagata, Y. Akagi, T. Yamaguchi, M. Odagi, A. Kittaka, M. Uesugi, K. Nagasawa
- Organizer
  20th Vitamin D Workshop
- Place of Presentation
  Rosen Hotel, Orland, USA
- Year and Date
  2017-03-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] (24S)-2α-[2-(テトラゾール-2-イル)エチル]-1α,24,25-トリヒドロキシビタミンD3の合成2017
- Author(s)
  高野真史，安田佳織，真野寛生，遠山枝李，榊利之，橘高敦史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] SYNTHESIS OF (24S)-ISOMER OF AH-1 CYP24A1 METABOLITE2017
- Author(s)
  M. Takano, K. Yasuda, H. Mano, E. Tohyama, T. Sakaki, and A. Kittaka
- Organizer
  20th Vitamin D Workshop
- Place of Presentation
  Rosen Hotel, Orland, USA
- Year and Date
  2017-03-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 7,8-シス-14-エピ-2-(3-ヒドロキシプロピル)-1α,25-ジヒドロキシ-19-ノルビタミンD3の合成2017
- Author(s)
  澤田大介、川越文裕、落合鋭士、竹内明子、角田真二、上村みどり、橘高敦史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 標準的Fmoc法固相合成のための2-チオウラシルPNAモノマー2017
- Author(s)
  杉山亨、長谷川元気、新倉千絵、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] アゾール基を有するビタミンＤ誘導体のCYP24A1による代謝2017
- Author(s)
  遠山枝李、安田佳織、真野寛生、鎌倉昌樹、生城真一、太田美穂、高野真史、橘高敦史、榊　利之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] CD環部側鎖にラクトン及びラクタムを有する活性型ビタミンD誘導体の合成研究2017
- Author(s)
  赤木祐介、山口卓也、永田亜希子、小田木陽、橘高敦史、上杉志成、長澤和夫
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 造腫瘍性代謝物様の活性を有する脂質代謝物としてのN-アシルドーパミンの同定2017
- Author(s)
  伊藤昭博、芹澤茉里子、Asad Ali Shah、前田里子、中田明子、松本洋太郎、有田誠、橘高敦史、上杉志成、吉田稔
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 4種の14-エピ-8,9-ジヒドロ-1α,25-ジヒドロキシ-19-ノルタキステロールの合成2017
- Author(s)
  川越文裕、澤田大介、竹内明子、上杉志成、橘高敦史
- Organizer
  第43回反応と合成の進歩シンポジウム（富山国際会議場）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] PEPTIDE NUCLEIC ACID POSSESSING PREQ1 AS A CATIONIC ANALOGUE OF GUANINE2017
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Organizer
  第54回ペプチド討論会（大阪府立大学、中百舌鳥キャンパス）
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2α位にアゾール基を有するビタミンＤ誘導体の代謝および骨密度上昇作用メカニズムの解明2016
- Author(s)
  遠山枝李、安田佳織、真野寛生、鎌倉昌樹、生城真一、太田美穂、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 2α-[2-(テトラゾール-2-イル)エチル]-1α,24,25-トリヒドロキシビタミンD3の合成2016
- Author(s)
  高野真史、安田佳織、遠山枝李、榊利之、橘高敦史
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 分割型ルシフェラーゼを用いたビタミンD受容体リガンド検出バイオセンサーの応用2016
- Author(s)
  真野寛生、西川美宇、安田佳織、生城真一、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 骨粗鬆症治療薬への応用を目指したビタミンＤ誘導体の CYP24A1 による代謝2016
- Author(s)
  遠山枝李、安田佳織、真野寛生、鎌倉昌樹、生城真一、太田美穂、高野真史、橘高敦史、榊利之
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  仙台
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 骨粗鬆症あるいは癌治療薬への応用を目指したビタミンＤ誘導体の代謝様式の解明2016
- Author(s)
  遠山枝李・安田佳織真野寛生・鎌倉昌樹生城真一・太田美穂高野真史・橘高敦史榊利之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ビタミンD受容体 (VDR) の活性を制御するノンセコステロイド型VDRリガンドの創製2016
- Author(s)
  三澤隆史、出水庸介、谷内出友美、大岡伸通、木下恵愛、野尻久雄、橘高敦史、槇島誠、内藤幹彦、栗原正明
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 25-ヒドロキシビタミンD3ラクトン代謝物と異性体の合成研究2016
- Author(s)
  樋口恵理香、杉山亨、高野真史、上杉志成、橘高敦史
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2α-[2-(テトラゾール-2-イル)エチル]-1α,24,25-トリヒドロキシビタミンD3の合成2016
- Author(s)
  高野真史，安田佳織，遠山枝李，榊利之，橘高敦史
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 短い側鎖を有する19-ノルビタミンD誘導体の合成と生物活性評価2016
- Author(s)
  川越文裕、安田佳織、高野真史、松本洋太郎、竹内明子、杉山亨、上杉志成、榊利之、橘高敦史
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] SYNTHESIS OF 7,8-CIS-VITAMIN D3 ANALOGS2016
- Author(s)
  D. Sawada, S. Kakuda, M. Kamimura-Takimoto, A. Takeuchi, Y. Matsumoto, and A. Kittaka
- Organizer
  19th Vitamin D Workshop
- Place of Presentation
  Boston, USA
- Year and Date
  2016-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] SYNTHESIS OF (24R)-2α-[2-(TETRAZOL-2-YL)ETHYL]-1α,24,25-TRIHYDROXYVITAMIN D32016
- Author(s)
  M. Takano, K. Yasuda, E. Tohyama, T. Sakaki, and A. Kittaka
- Organizer
  19th Vitamin D Workshop
- Place of Presentation
  Boston, USA
- Year and Date
  2016-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 22-ヒドロキシ-2-メチリデン-19,23,24,25,26,27-ヘキサノルビタミンD3と異性体の合成2016
- Author(s)
  川越文裕、高野真史、松本洋太郎、杉山亨、上杉志成、橘高敦史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 25-ヒドロキシビタミンD3ラクトン代謝産物と異性体の合成研究2016
- Author(s)
  樋口恵理香、杉山　亨、高野真史、上杉志成、橘高敦史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 強い骨密度上昇作用を有するビタミンD誘導体の代謝様式の解明2016
- Author(s)
  遠山枝李・安田佳織生城真一・鎌倉昌樹高野真史・橘高敦史榊利之
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 2位置換基上にアゾールを有するビタミンD3誘導体（AH-1）のCYP24A1代謝物の化学合成2016
- Author(s)
  高野真史、安田佳織、真野寛生、遠山枝李、榊　利之、橘高敦史
- Organizer
  第2回 Neo Vitamin D Workshop 学術集会
- Place of Presentation
  TKPガーデンシティ品川
- Year and Date
  2016-08-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2α位にアゾール基を有するビタミンＤ誘導体の代謝および骨密度上昇作用メカニズムの解明2016
- Author(s)
  遠山枝李、安田佳織、真野寛生、鎌倉昌樹、生城真一、太田美穂、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 分割型ルシフェラーゼを用いたビタミンD受容体リガンド検出バイオセンサーの応用2016
- Author(s)
  真野寛生、西川美宇、安田佳織、生城真一、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2α-[2-(テトラゾール-2-イル)エチル]-1α,25(OH)2-ビタミンD3のCYP24A1代謝物の合成2016
- Author(s)
  高野真史、安田佳織、遠山枝李、榊利之、橘高敦史
- Organizer
  第46回複素環化学討論会
- Place of Presentation
  金沢歌劇座
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] NEW FMOC 2-THIOURACIL MONOMER FOR THE SYNTHESIS OF PSEUDO-COMPLEMENTARY PNA2016
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 機能性分子を目指した修飾デアザグアニンのペプチド核酸への導入2016
- Author(s)
  杉山亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  第46回複素環化学討論会
- Place of Presentation
  金沢歌劇座
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ビタミンD誘導体のCYP24A1代謝物の化学合成2016
- Author(s)
  高野真史，安田佳織，真野寛生,　遠山枝李，榊利之，橘高敦史
- Organizer
  第42回反応と合成の進歩シンポジウム
- Place of Presentation
  清水文化会館
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] Fmoc法による擬似相補的PNAの合成2016
- Author(s)
  杉山亨、長谷川元気、新倉千絵、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ヒトATRA耐性急性前骨髄球性白血病細胞の分化誘導活性を有するノンセコステロイド型ビタミンD受容体リガンド2016
- Author(s)
  野尻久雄、村田拓哉、橘高敦史、出水庸介、三澤隆史、栗原正明
- Organizer
  第2回 Neo Vitamin D Workshop 学術集会
- Place of Presentation
  TKPガーデンシティ品川
- Year and Date
  2016-08-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] Fmoc固相合成法のための擬似相補的PNAモノマーの開発2016
- Author(s)
  杉山亨、長谷川元気、新倉千絵、栗原正明、橘高敦史
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学薬学部
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 造腫瘍性代謝物様の活性を有する新規内因性脂質代謝物の発見2016
- Author(s)
  伊藤昭博、芹澤茉里子、Asad Ali Shah、三野光識、松岡聖二、中田明子、前田里子、松本洋太郎、中尾洋一、有田誠、橘高敦史、上杉志成、吉田稔
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] CF3TMSを用いたファレカルシトリオール誘導体の合成2016
- Author(s)
  川越文裕、高野真史、杉山亨、上杉志成、橘高敦史
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] CYP24A1はビタミンD誘導体の開発における鍵酵素である2016
- Author(s)
  榊　利之、安田佳織、生城真一、山本恵子、橘高敦史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 転写因子 HIF-1αをターゲットとする新規アシルドーパミンの合成2016
- Author(s)
  松本洋太郎、溝越怜、本谷小佑里、伊藤昭博、橘高敦史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ビタミンD誘導体合成：制がんおよび骨形成活性への効果2016
- Author(s)
  橘高敦史、高野真史、澤田大介
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] デアザグアニン誘導体を持つPNAの合成2016
- Author(s)
  杉山　亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2α-[2-(テトラゾール-2-イル)エチル]-1α,25(OH)2-ビタミンD3代謝物の同定2016
- Author(s)
  高野真史，安田佳織，榊　利之，橘高敦史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 25-ヒドロキシビタミンD3ラクトン代謝産物と異性体の合成研究2016
- Author(s)
  樋口恵理香、杉山　亨、高野真史、上杉志成、橘高敦史
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] 22-ヒドロキシ-2-メチリデン-19, 23, 24, 25, 26, 27-へキサノルビタミンD3と異性体の合成2016
- Author(s)
  川越文裕、高野真史、松本洋太郎、杉山　亨、上杉志成、橘高敦史
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] デアザグアニン誘導体を持つPNAの合成2016
- Author(s)
  杉山　亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] 7,8-cis-19-Norvitamin D3の合成とVDR結合および7,8-cis-vitamin D3の化学的性質2015
- Author(s)
  澤田大介、松本洋太郎、川越文裕、竹内明子、角田真二、上村みどり、橘高敦史
- Organizer
  第348回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京大学薬学部（東京都文京区）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 分割型ルシフェラーゼを用いたビタミンDバイオセンサーの開発2015
- Author(s)
  真野寛生、西川美宇、安田佳織、鎌倉昌樹、生城真一、高野真史、斉藤　望、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良県新公会堂（奈良県奈良市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 強い骨密度上昇作用を有するビタミンD誘導体の代謝様式の解明2015
- Author(s)
  遠山枝李、安田佳織、生城真一、鎌倉昌樹、高野真史、橘高敦史、榊　利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良県新公会堂（奈良県奈良市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2α位にトリアゾリルプロピル基を有する19-ノル型ビタミンD3の合成と生物活性評価2015
- Author(s)
  高野真史、樋口恵理香、安田佳織、榊　利之、橘高敦史
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良県新公会堂（奈良県奈良市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] SYNTHESIS, METABOLISM, AND BIOLOGICAL ACTIVITY OF 2-[3-(TETRAZOLYL)PROPYL]-1α,25-DIHYDROXY-19-NORVITAMIN D32015
- Author(s)
  M. Takano, E. Higuchi, K. Yasuda, E. Tohyama, A. Takeuchi, T. Sakaki, and A. Kittaka
- Organizer
  18th Vitamin D Workshoｐ
- Place of Presentation
  Delft, Holland
- Year and Date
  2015-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] Incorporation of a peptide nucleic acid into a normal human fibroblast cell reduced type I collagen production2015
- Author(s)
  Yasutada Imamura, Suzuka Tsuboi, Toru Sugiyama, Atsushi Kittaka, Yonchol Shin
- Organizer
  9th International Conference on Proteoglycans and 10th Pan Pacific Connective Tissue Societies Symposium
- Place of Presentation
  Ewha Womans University（韓国ソウル）
- Year and Date
  2015-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] 機能性PNAの開発を目指した修飾デアザグアニン含有PNAオリゴマーの合成2015
- Author(s)
  杉山　亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  第５２回ペプチド討論会
- Place of Presentation
  平塚市中央公民館（神奈川県平塚市）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] CYP24A1 is a key enzyme to develop vitamin D analogs as anti-osteoporosis or anti-cancer drugs2015
- Author(s)
  Toshiyuki Sakaki, Kaori Yasuda, Shinichi Ikushiro, Keiko Yamamoto, Tai C. Chen, Atsushi Kittaka
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  国立オリンピック記念青少年総合センター（東京都渋谷区）
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] CYP24A1-dependent metabolism of a promising vitamin D analog for osteoporosis treatment2015
- Author(s)
  Eri Tohyama, Kaori Yasuda, Masaki Kamakura, Shinichi Ikushiro, Masashi Takano, Atsushi Kittaka, Toshiyuki Sakaki
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  国立オリンピック記念青少年総合センター（東京都渋谷区）
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] Incorporation of a peptide nucleic acid into a normal human fibroblast cell reduced type I collagen production2015
- Author(s)
  Yasutada Imamura, Suzuka Tsuboi, Toru Sugiyama, Atsushi Kittaka, Yonchol Shin
- Organizer
  9th International Conference on Proteoglycans and 10th Pan Pacific Connective Tissue Societies Symposium
- Place of Presentation
  韓国ソウル Ewha Womans University
- Year and Date
  2015-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ビタミンD誘導体合成2015
- Author(s)
  齋藤望、高野真史、澤田大介、橘高敦史
- Organizer
  第1回 Neo Vitamin D Workshop 学術集会
- Place of Presentation
  大津プリンスホテル（滋賀県大津市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2位にアゾールプロピル基を有する19-ノル型ビタミンD3の合成と生物活性評価2015
- Author(s)
  高野真史，樋口恵理香，安田佳織，榊利之，橘高敦史
- Organizer
  第1回 Neo Vitamin D Workshop 学術集会
- Place of Presentation
  大津プリンスホテル（滋賀県大津市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ヒト由来メチルステロール酸化酵素SC4MOLによるビタミンD誘導体の代謝2015
- Author(s)
  安田佳織、岩永由麻、小川和亮、高野真史、橘高敦史、太田美穂、鎌倉昌樹、生城真一、榊利之
- Organizer
  第1回 Neo Vitamin D Workshop 学術集会
- Place of Presentation
  大津プリンスホテル（滋賀県大津市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] アシルドーパミン合成法の最適化に関する研究2015
- Author(s)
  松本洋太郎、溝越怜、本谷小佑里、伊藤昭博、上杉志成、橘高敦史
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉県船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 2位置換基上にアゾールアルキル基を有する19-ノルビタミンD3の合成2015
- Author(s)
  茂田佳奈子、矢野弘樹、雨宮綾子、樋口恵理香、高野真史、橘高敦史
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部（千葉県船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 高い骨形成作用を有するビタミンD誘導体の合成、活性評価及び代謝研究2015
- Author(s)
  高野真史，安田佳織，樋口恵理香，遠山枝李，齋藤博，角田真二，高木健一郎，落合鋭士，堀江恭平，原田善史，上村みどり，竹之内一弥，榊利之，橘高敦史
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  近畿大学11月ホール（大阪府東大阪市）
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] Elucidation and regulation of novel function of N-acyldopamines2015
- Author(s)
  Akihiro Ito, Mariko Serizawa, Satoko Maeda, Akiko Nakata, Yotaro Matsumoto, Yoichi Nakao, Minoru Yoshida, Atsushi Kittaka, Motonari Uesugi
- Organizer
  【CREST疾患代謝】第３回合同領域会議
- Place of Presentation
  京都・島津製作所本社講堂（京都市中京区）
- Year and Date
  2015-11-29
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ノンセコステロイド型ビタミンD受容体リガンドの創製～官能基変換による活性制御～2015
- Author(s)
  三澤隆史、依岡桃子、出水庸介、谷内出友美、大岡伸道、木下恵愛、野尻久雄、橘高敦史、槇島　誠、内藤幹彦、栗原正明
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 修飾デアザグアニン含有PNAオリゴマーの合成2015
- Author(s)
  杉山亨,　桑田啓子,　今村保忠,　出水庸介,　栗原正明,　高野真史,　橘高敦史
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] SYNTHESIS OF PNA OLIGOMERS CONTAINING MODIFIED2015
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚中央公民館（神奈川県平塚市）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] ノンセコステロイド型VDRリガンドによるATRA耐性急性前骨髄球性白血病細胞の分化誘導2015
- Author(s)
  野尻久雄、村田拓哉、橘高敦史、出水庸介、三澤隆史、栗原正明
- Organizer
  第38回日本分子生物学会年会 & 第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（神戸市中央区）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K07869
[Presentation] 修飾デアザグアニン含有PNAオリゴマーの合成2015
- Author(s)
  杉山　亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  第３３回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] 8,9-ジヒドロ-19-ノルタキステロールの合成研究2014
- Author(s)
  松本洋太郎、山田徹、森幸樹、澤田大介、橘高敦史
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] ビタミンD：驚異のセコステロイド骨格2014
- Author(s)
  橘高敦史
- Organizer
  芝浦工業大学大学院講義
- Place of Presentation
  芝浦工業大学
- Year and Date
  2014-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2位置換基上にトリアゾール環を有する19-ノルビタミンD3の合成研究2014
- Author(s)
  小川圭瞳、谷川有梨紗、宮田英美、高野真史、松本洋太郎、橘高敦史
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] ビタミンD誘導体設計・合成・生物活性　～ビタミンD作用の多様性～2014
- Author(s)
  橘高敦史
- Organizer
  長崎大学大学院講義（メディシナルケミストリー特論１）
- Place of Presentation
  長崎大学
- Year and Date
  2014-05-27
- Invited
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 新規セコステロイド合成と受容体相互作用2014
- Author(s)
  橘高敦史
- Organizer
  長崎大学学術講演会
- Place of Presentation
  長崎大学
- Year and Date
  2014-05-26
- Invited
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] ビタミンDと太陽光2014
- Author(s)
  橘高敦史
- Organizer
  近畿化粧品原料協会学術講演会
- Place of Presentation
  薬業年金会館、大阪
- Year and Date
  2014-07-22
- Invited
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 側鎖に金属錯体を持ったβ-PNAによる配列特異的DNA切断2014
- Author(s)
  杉山　亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本市総合体育館　（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] 側鎖に金属錯体を持ったβ-PNAによる配列特異的DNA切断2014
- Author(s)
  杉山亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  日本薬学会第134年会（熊本）
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2-[3-(テトラゾール-2-イル)プロピル]-1α,25(OH)2-19-ノルビタミンD3の合成2014
- Author(s)
  高野真史，樋口恵理香，東和成，平野圭祐，竹内明子，澤田大介，橘高敦史
- Organizer
  日本薬学会第134年会（熊本）
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 14-エピ-8,9-ジヒドロ-1α,25-ジヒドロキシ-19-ノルタキステロールの合成2014
- Author(s)
  澤田大介、松本洋太郎、竹内明子、橘高敦史
- Organizer
  日本薬学会第134年会（熊本）
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] DESIGN AND SYNTHESIS OF 2α-HETEROARALKYL-1α,25-DIHYDROXYVITAMIN D3 ANALOGS AS STRONG LIGANDS FOR VITAMIN D RECEPTOR2013
- Author(s)
  M. Matsuo, A. Hasegawa, M. Takano, Y. Nakamura, H. Saitou, S. Kakuda, K. Takagi, E. Ochiai, K. Horie, M. T. Kamimura, K. Takenouchi, D. Sawada, and A. Kittaka
- Organizer
  16th Vitamin D Workshop（San Francisco, USA）
- Place of Presentation
  The Palace Hotel
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] Synthesis of 14-Epi-19-Nortachysterol and Elucidation of Its Binding Affinity and Configuration for the Human Vitamin D Receptor2013
- Author(s)
  D. Sawada, Y. Tsukuda, K. Horie, E. Ochiai, S. Kakuda, M. Takimoto-Kamimura, A. Kittaka
- Organizer
  14th Tetrahedron Symposium
- Place of Presentation
  Vienna
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 14-epi-tachysterol類の合成とVDR結合様式の解明2013
- Author(s)
  澤田大介、堀江恭平、落合鋭士、竹内明子、角田真二、上村みどり、橘高敦史
- Organizer
  日本ビタミン学会第65回大会(東京）
- Place of Presentation
  一橋講堂
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] ビタミンD誘導体設計・合成と初期的生物活性及び制癌活性の新しい知見2013
- Author(s)
  橘高敦史
- Organizer
  キッセイ薬品工業株式会社中央研究所・社内講演会
- Place of Presentation
  キッセイ薬品工業株式会社中央研究所（長野）
- Invited
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] C5-C6 Coupling of MART-10 Synthesis and Its Clinical Implication in Cancer Treatment and Prevention2013
- Author(s)
  Masashi Takano, Kun-Chun Chiang, Horng-Heng Juang, Kaori Yasuda, Toshiyuki Sakaki, Toshimasa Itoh, Keiko Yamamoto, Daisuke Sawada, John N. Flanagan, Gunnar Norstedt, Tai C. Chen, and Atsushi Kittaka
- Organizer
  第10回カルボアニオン化学国際会議（ISCC-10、同志社大学）
- Place of Presentation
  同志社大学
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2α-アゾールエチル基を有する1α,25-ジヒドロキシビタミンD3の合成と生物活性評価2013
- Author(s)
  橘高敦史、松尾実紀、長谷川麻美、高野真史、澤田大介、齋藤　博、角田真二、高木健一郎、落合鋭士、堀江恭平、上村みどり、竹之内一弥
- Organizer
  第340回脂溶性ビタミン総合研究委員会（芝浦工大）
- Place of Presentation
  芝浦工業大学芝キャンパス
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] Sequence-specific cleavage of DNA by β-peptide nucleic acid bearing a pendant metal complex2013
- Author(s)
  Toru Sugiyama, keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Organizer
  4th Asia-Pacific International Peptide Symposium
- Place of Presentation
  ホテル阪急エキスポパーク（大阪府吹田市）
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] 14-epi-tachysterol類の合成、生物活性評価、及び受容体結合様式の解明2013
- Author(s)
  澤田大介，佃　勇也，堀江恭平，竹内明子，角田真二，上村みどり，橘高敦史
- Organizer
  第31回メディシナルケミストリーシンポジウム（広島）
- Place of Presentation
  広島アステールプラザ
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] Sequence-Specific Cleavage of DNA by a Chiral Peptide Nucleic Acid Bearing a Pendant Metal Complex2013
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Organizer
  第50回ペプチド討論会（大阪）
- Place of Presentation
  ホテル阪急エキスポパーク
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 7,8-cis-vitamin D3類の合成、活性評価、及びVDR結合様式の解明2013
- Author(s)
  澤田大介、斎藤博、堀江恭平、高木健一郎、竹内明子、上村みどり、橘高敦史
- Organizer
  第39回反応と合成の進歩シンポジウム（九州大学）
- Place of Presentation
  九州大学医学部百年記念講堂
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] ビタミンＤとくすり2013
- Author(s)
  橘高敦史
- Organizer
  帝京大学公開講座
- Place of Presentation
  帝京大学板橋キャンパス
- Invited
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2α置換基上にアゾール環を有する19-ノル型ビタミンD3の合成研究2013
- Author(s)
  樋口恵理香、高野真史、澤田大介、橘高敦史
- Organizer
  第57回日本薬学会関東支部大会（帝京大学）
- Place of Presentation
  帝京大学板橋キャンパス
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 7,8-cis-1α,25(OH)2-19-norvitamin D3の合成と活性評価2013
- Author(s)
  澤田大介、森　幸樹、安部成郁、近藤美保、塩田真由美、竹内明子、橘高敦史
- Organizer
  第57回日本薬学会関東支部大会（帝京大学）
- Place of Presentation
  帝京大学板橋キャンパス
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 長鎖アルキル基を持つノンセコステロイド型VDRリガンドの創製2012
- Author(s)
  倉島恵愛、橘高敦史, 他4名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 活性型ビタミンD_3誘導体の2α側鎖上の二級水酸基の効果と生物活性評価2012
- Author(s)
  高野真史、榊利之、橘高敦史, 他11名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 優れた医療人の育成と基礎研究の両立を目指して2012
- Author(s)
  橘高敦史
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  昭和大学
- Invited
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2α-(3-ヒドロキシプロピル)-1α,25-ジヒドロキシ-19-ノルビタミンD3（MART-10）とその類縁体の合成と制がん活性等2012
- Author(s)
  橘高敦史ら
- Organizer
  第336回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京農業大学
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 1a, 4, 25-トリヒドロキシビタミンD_3の合成とヒト水酸化酵素による代謝に関する研究2012
- Author(s)
  澤田大介、榊利之、橘高敦史(他5名)
- Organizer
  日本薬学会第132年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 活性型ビタミンD_3誘導体の2a側鎖上の二級水酸基の効果と生物活性評価2012
- Author(s)
  高野真史、榊利之、橘高敦史(他11名)
- Organizer
  日本薬学会第132年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 長鎖アルキル基を持つノンセコステロイド型VDRリガンドの創製2012
- Author(s)
  倉島恵愛、橘高敦史(他4名)
- Organizer
  日本薬学会第132年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 1α,4,25-トリヒドロキシビタミンD_3の合成とヒト水酸化酵素による代謝に関する研究2012
- Author(s)
  澤田大介、榊利之、橘高敦史, 他5名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis Of New C15-Substituted 16-Ene-1α,25-dihydroxyvitamin D3 Analogs and The Receptor-ligand Interaction Studies2012
- Author(s)
  Atsushi Kittaka et al.
- Organizer
  13th Tetrahedron Symposium
- Place of Presentation
  台北
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 14-エピ-19-ノルタキステロールの合成とVDRリガンド骨格としての可能性2011
- Author(s)
  橘高敦史
- Organizer
  第332回脂溶性ビタミン総合研究委員会
- Place of Presentation
  昭和薬科大学
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] 新たなビタミンD骨格14-epi-19-ノルタキステロール2011
- Author(s)
  橘高敦史
- Organizer
  帝人・核内レセプター創薬研究会(招待講演)
- Place of Presentation
  霞が関ナレッジスクエア(千代田区)
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] Synthesis of C15-Modified 16-ene-active vitamin D3 analogs for the receptor-ligand interaction studies2011
- Author(s)
  Atsushi Kittaka, et al
- Organizer
  4th Symposium Vitamin D Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Schlossberg Hotel(Homburg, Germany)
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] 2a側鎖上にアゾール環を有する活性型ビタミンD_3誘導体の合成と生物活性評価2011
- Author(s)
  松尾実紀, 長谷川麻美, 橘高敦史(他3名)
- Organizer
  日本薬学会第131年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2α位に置換基を有するビタミンD誘導体のヒト体内における代謝予測2011
- Author(s)
  安田佳織、生城真一、鎌倉昌樹、高野真史、齋藤望、橘高敦史、太田美穂、榊利之
- Organizer
  日本ビタミン学会第63回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of C15-Modified 16-ene-active vitamin D_3 analogs for the receptor-ligand interaction studies2011
- Author(s)
  Atsushi Kittaka, et al
- Organizer
  4th Symposium Vitamin D Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Schlossberg Hotel (Homburg, Germany)
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] 新規15β-ヒドロキシ活性型ビタミンD_3誘導体の合成と生物活性評価2011
- Author(s)
  熊谷剛, 澤田大介, 橘高敦史(他8名)
- Organizer
  日本薬学会第131年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Evaluation and characterization of 14-epi-19-nortachysterol analogs from 14-epi-19-norprevitamin D_32011
- Author(s)
  Sawada D, Kittaka A(他6名)
- Organizer
  4th Symposium Vitamin D Analogs in Can cer Prevention and Therapy
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] hCYP24A1代謝抵抗性活性型ビタミンD_3誘導体の合成とATRA耐性APL細胞への活性評価2011
- Author(s)
  高野真史, 榊利之, 橘高敦史(他11名)
- Organizer
  日本薬学会第131年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of C15-Modified 16-ene-active vitamin D_3 analogs for the receptor-ligand interaction studies2011
- Author(s)
  Kittaka A(他11名)
- Organizer
  4th Symposium Vitamin D Analogs in Cancer Prevention and Therapy
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2a位にアゾール環側鎖を有する活性型ビタミンD_3の合成と生物活性評価2011
- Author(s)
  松尾実紀、橘高敦史(他11名)
- Organizer
  日本ビタミン学会第63回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] hCYP24A1代謝抵抗性活性型ビタミンD_3誘導体の合成とATRA耐性APL細胞への活性評価2011
- Author(s)
  高野真史, 榊利之, 橘高敦史, 他11名
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2位置換14-epi-19-Nortachysterol誘導体の合成と活性評価2011
- Author(s)
  澤田大介、齋藤博、橘高敦史, 他3名
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2α側鎖上にアゾール環を有する活性型ビタミンD_3誘導体の合成と生物活性評価2011
- Author(s)
  松尾実紀, 長谷川麻美, 橘高敦史, 他3名
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規15β-ヒドロキシ活性型ビタミンD_3誘導体の合成と生物活性評価2011
- Author(s)
  熊谷剛, 澤田大介, 橘高敦史, 他8名
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 4位置換キラルPNAの合成2011
- Author(s)
  杉山亨、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡、静岡
- Data Source
  KAKENHI-PROJECT-20590099
[Presentation] Synthesis and DNA binding properties of ss-chiral peptide nucleic acid2011
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Organizer
  8^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-20590099
[Presentation] ss-キラルPNAの合成とDNA結合特性2011
- Author(s)
  杉山亨、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌コンベンションセンター、札幌市
- Data Source
  KAKENHI-PROJECT-20590099
[Presentation] 2α位に置換基を有するビタミンD誘導体のヒト体内における代謝予測2011
- Author(s)
  安田佳織、橘高敦史、榊利之, 他8名
- Organizer
  日本ビタミン学会第63回大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] New Skeleton in Vitamin D Family : 14-epi-19-Nortachysterol and Its Unprecedented Binding Configuration for the Human Vitamin D Receptor2011
- Author(s)
  Sawada D, Kittaka A(他6名)
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 14-エピ-19-ノルタキステロールの合成とVDRリガンド骨格としての可能性2011
- Author(s)
  澤田大介、橘高敦史(他5名)
- Organizer
  第332回脂溶性ビタミン委員会
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 1a, 4, 25-トリヒドロキシビタミンD_3の合成とヒト水酸化酵素による代謝に関する研究2011
- Author(s)
  澤田大介、橘高敦史(他5名)
- Organizer
  第37回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Evaluation and characterization of 14-epi-19-nortachysterol analogs from 14-epi-19-norprevitamin D_32011
- Author(s)
  Sawada D, Kittaka A, 他6名
- Organizer
  4th Symposium Vitamin D Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Homburg, Germany
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2α位にアゾール環側鎖を有する活性型ビタミンD_3の合成と生物活性評価2011
- Author(s)
  松尾実紀、橘高敦史, 他11名
- Organizer
  日本ダタミン学会第63回大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 14-エピ-19-ノルタキステロールの合成とVDRリガンド骨格としての可能性2011
- Author(s)
  澤田大介、橘高敦史, 他5名
- Organizer
  第332回脂溶性ビタミン委員会
- Place of Presentation
  東京
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 14-epi-19-Nortachysterol類の合成と受容体結合様式の解明2011
- Author(s)
  澤田大介、橘高敦史, 他5名
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of C15-Modified 16-ene-active vitamin D_3 analogs for the receptor-ligand interaction studies2011
- Author(s)
  Kittaka A, 他11名
- Organizer
  4th Symposium Vitamin D Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Homburg, Germany
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] New Skeleton in Vitamin D Family : 14-epi-19-Nortachysterol and Its Unprecedented Binding Configuration for the Human Vitamin D Receptor2011
- Author(s)
  Sawada D, Kittaka A, 他6名
- Organizer
  8th AFMC International Medicinal Chemistry Symposium (AIMECS 2011)
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新たなビタミンD骨格14-epi-19-ノルタキステロール2011
- Author(s)
  橘高敦史
- Organizer
  帝人・核内レセプター創薬研究会
- Place of Presentation
  霞が関ナレッジスクエア(千代田区)(招待講演)
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] ビタミンD誘導体の合成と生物活性2010
- Author(s)
  橘高敦史
- Organizer
  研究成果発表フォーラム
- Place of Presentation
  東京ビッグサイト
- Year and Date
  2010-07-02
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] プレビタミンD研究から19-ノルタキステロールへ2010
- Author(s)
  橘高敦史
- Organizer
  第5回帝人VD3研究会
- Place of Presentation
  帝人ファーマ生物医学総合研究所
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] 変異VDR(Arg274Leu)に対するセコステロイドリガンドの設計と合成2010
- Author(s)
  橘高敦史, ら
- Organizer
  第329回脂溶性ビタミン総合研究委員会
- Place of Presentation
  国立栄養研究所
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] Synthesis of vitamin D analogs as ligands for mutant human vitamin D receptor(Arg274Leu)2010
- Author(s)
  Atsushi Kittaka, et al.
- Organizer
  240th American Chemical Society
- Place of Presentation
  Boston(USA)
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] Synthesis of new C15-substituted 16-ene-1a, 25-dihydroxyvitamin D_32010
- Author(s)
  Go Kumagai, Daisuke Sawada, Atsushi Kittaka(他11名)
- Organizer
  環太平洋国際化学会議
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Evaluation of 14-epi-19-nortachysterol analogs from 14-epi-19-norprevitamin D_32010
- Author(s)
  Daisuke Sawada, Yuya Tsukuda, Atsushi Kittaka(他9名)
- Organizer
  環太平洋国際化学会議
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Evaluation of 14-epi-19-nortachysterol analogs from 14-epi-19-norprevitamin D_32010
- Author(s)
  Daisuke Sawada, Yuya Tsukuda, Atsushi Kittaka, 他9名
- Organizer
  環太平洋国際化学会議
- Place of Presentation
  ハワイ
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of 2α-heteroaralkylvitamin D_3 analogs with potent biological activity2010
- Author(s)
  Miki Matsuo, Asami Hasegawa, Atsushi Kittaka, 他10名
- Organizer
  環太平洋国際化学会議
- Place of Presentation
  ハワイ
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of new C15-substituted 16-ene-1α,25-dihydroxyvitamin D_32010
- Author(s)
  Go Kumagai, Daisuke Sawada, Atsushi Kittaka, 他11名
- Organizer
  環太平洋国際化学会議
- Place of Presentation
  ハワイ
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒト前立腺細胞における25-hydroxy-19-nor vitamin D_3の作用機構2010
- Author(s)
  宗綱栄二, 橘高敦史, 榊利之, 他7名
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of a series of vitamin D analogs as ligands for human vitamin D receptor : super agonists, antagonists, and studies on metabolism2010
- Author(s)
  Atsushi Kittaka, Daisuke Sawada, Toshiyuki Sakaki, 他11名
- Organizer
  環太平洋国際化学会議
- Place of Presentation
  ハワイ
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 14-エピ-19-ノルタキステロール誘導体の合成と活性評価2010
- Author(s)
  澤田大介, 佃勇也, 堀江恭平, 落合鋭士, 齋藤博, 角田真二, 上村みどり, 竹之内一弥, 橘高敦史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規16-エン-1α, 15α, 25-トリヒドロキシビタミンD_3の合成研究2010
- Author(s)
  熊谷剛, 高野真史, 澤田大介, 齋藤博, 竹之内一弥, 橘高敦史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規2α-[2-(テトラゾール-1-イル)エチル]活性型ビタミンD_3の合成2010
- Author(s)
  松尾実紀, 長谷川麻美, 高野真史, 中村優子, 齋藤博, 角田真二, 高木健一郎, 落合鋭士, 堀江恭平, 上村みどり, 竹之内一弥, 澤田大介, 橘高敦史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of Novel C15-Substituted Active Vitamin D_3 Analogs with 16-Ene CD-Ring2010
- Author(s)
  Go Kumagai, Kanako Shindo, Atsushi Kittaka(他9名)
- Organizer
  第21回日仏医薬精密化学会議
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of 2a-[2-(T etrazolyl) ethyl]-1a, 25-dihydroxy Vita min D_32010
- Author(s)
  Miki Matsuo, Asami Hasegawa, Atsushi Kittaka(他10名)
- Organizer
  第21回日仏医薬精密化学会議
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2a位に2-(1H-テトラゾール-1-イル)エチル基及び2-(2H-テトラゾール-2-イル)エチル基を有する活性型ビタミンD_3の合成と生物活性評価2010
- Author(s)
  澤田大介, 佃勇也, 橘高敦史(他6名)
- Organizer
  日本ビタミン学会第62回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規15位置換活性型ビタミンD_3の合成研究2010
- Author(s)
  熊谷剛, 澤田大介, 橘高敦史(他11名)
- Organizer
  日本ビタミン学会第62回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of vitamin D analogs as ligands for mutant human vitamin D receptor(Arg274Leu)2010
- Author(s)
  Shinobu Honzawa, Naoyuki Takahashi, Atsushi Kittaka(他5名)
- Organizer
  240th American Chemical Society
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 変異VDR(Arg274Leu)に対するセコステロイドリガンドの設計と合成2010
- Author(s)
  本澤忍、高橋尚志, 橘高敦史、榊利之(他14名)
- Organizer
  第329回脂溶性ビタミン総合研究委員会
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] α側鎖上にトリアゾール環を有する活性型ビタミンD_3誘導体の合成2010
- Author(s)
  松尾実紀、高野真史、橘高敦史(他9名)
- Organizer
  第54回日本薬学会関東支部大会
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of 2a-heteroaralkylvitamin D_3 analogs with potent biological activity2010
- Author(s)
  Go Kumagai, Daisuke Sawada, Atsushi Kittaka(他11名)
- Organizer
  環太平洋国際化学会議
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of 2a-heteroaralkylvitamin D_3 analogs with potent biological activity2010
- Author(s)
  Miki Matsuo, Asami Hasegawa, Atsushi Kittaka(他10名)
- Organizer
  環太平洋国際化学会議
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] レチノイン酸耐性ヒト前骨髄球性白血病細胞の分化誘導におけるCYP24A1抵抗性新規ビタミンD誘導体の有用性2010
- Author(s)
  松本直樹、榊利之、橘高敦史(他3名)
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] CYP105A1二重変異体によるビタミンD_3の代謝とその反応機構2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之(他5名)
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of a series of vitamin D an alogs as ligands for human vitamin D receptor : super agonists, antagonists, and studies on metabolism2010
- Author(s)
  Atsushi Kittaka, Daisuke Sawada, Toshiyuki Sakaki(他11名)
- Organizer
  環太平洋国際化学会議
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒト前立腺細胞における25-hydroxy-19-nor vitamin D_3の作用機構2010
- Author(s)
  宗綱栄二, 橘高敦史, 榊利之(他7名)
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規15位置換活性型ビタミンD_3の合成とビタミンD受容体との相互作用2010
- Author(s)
  新藤香菜子、熊谷剛、橘高敦史(他10名)
- Organizer
  第36回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規15位置換活性型ビタミンD_3の合成とビタミンD受容体との相互作用2010
- Author(s)
  熊谷剛、澤田大介、橘高敦史(他9名)
- Organizer
  第54回日本薬学会関東支部大会
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] α-ヘテロアラルキル活性型ビタミンD_3誘導体の合成と生物活性2010
- Author(s)
  松尾実紀, 長谷川麻美、橘高敦史(他11名)
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of Novel C15-Substituted Active Vitamin D_3 Analogs with 16-Ene CD-Ring2010
- Author(s)
  Go Kumagai, Kanako Shindo, Atsushi Kittaka, 他9名
- Organizer
  第21回日仏医薬精密化学会議(京都)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of 2α-[2-(Tetrazolyl)ethyl]-1α, 25-dihydroxy Vitamin D_32010
- Author(s)
  Miki Matsuo, Asami Hasegawa, Atsushi Kittaka, 他10名
- Organizer
  第21回日仏医薬精密化学会議
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2α位に2-(1H-テトラゾールー1-イル)エチル基及び2-(2H-テトラゾールー2-イル)エチル基を有する活性型ビタミンD_3の合成と生物活性評価2010
- Author(s)
  澤田大介, 佃勇也, 橘高敦史, 他6名
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規15位置換活性型ビタミンD_3の合成研究2010
- Author(s)
  熊谷剛, 澤田大介, 橘高敦史, 他11名
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] CYP105A1二重変異体発現放線菌によるビタミンD_3の代謝2010
- Author(s)
  安田佳織, 杉本宏, 橘高敦史, 榊利之, 他5名
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規2a-[2-(テトラゾール-1-イル)エチル]活性型ビタミンD_3の合成2010
- Author(s)
  松尾実紀、橘高敦史(他11名)
- Organizer
  日本薬学会第130年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 14-エピ-19-ノルタキステロール誘導体の合成と活性評価2010
- Author(s)
  澤田大介、橘高敦史(他7名)
- Organizer
  日本薬学会第130年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規16-エン-1a, 15a, 25-トリヒドロキシビタミンD_3の合成研究2010
- Author(s)
  熊谷剛、高野真史、澤田大介、齋藤博、竹之内一弥、橘高敦史
- Organizer
  日本薬学会第130年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ビタミンD受容体リガンド結合領域のwater channelとの相互作用を基盤とする新規ビタミンD誘導体の設計と合成2010
- Author(s)
  橘高敦史
- Organizer
  明治薬科大学セミナー
- Place of Presentation
  明治薬科大学
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] Synthesis of a series of vitamin D analogs as ligands for human vitamin Dreceptor super agonists, antagonists, and studies on metabolism2010
- Author(s)
  Atsushi Kittaka, et al.
- Organizer
  環太平洋国際化学会議2010
- Place of Presentation
  Honolulu(USA)
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] 2α側鎖上にトリアゾール環を有する活性型ビタミンD_3誘導体の合成2010
- Author(s)
  松尾実紀、高野真史、橘高敦史, 他9名
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 変異VDR(Arg274Leu)に対するセコステロイドリガンドの設計と合成2010
- Author(s)
  本澤忍、高橋尚志, 橘高敦史, 榊利之, 他14名
- Organizer
  第329回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of vitamin D analogs as ligands for mutant human vitamin D receptor (Arg274Leu)2010
- Author(s)
  Shinobu Honzawa, Naoyuki Takahashi, Atsushi Kittaka, 他5名
- Organizer
  240th American Chemical Society
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2α-ヘテロアラルキル活性型ビタミンD_3誘導体の合成と生物活性2010
- Author(s)
  松尾実紀, 長谷川麻美、橘高敦史, 他11名
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規15位置換活性型ビタミンD_3の合成とビタミンD受容体との相互作用2010
- Author(s)
  新藤香菜子、熊谷剛、橘高敦史, 他10名
- Organizer
  第36回反応と合成の進歩シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 新規15β-ヒドロキシ活性型ビタミンD_3誘導体の合成研究2010
- Author(s)
  熊谷剛、澤田大介、橘高敦史, 他9名
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] レチノイン酸耐性ヒト前骨髄球性白血病細胞の分化誘導におけるCYP24A1抵抗性新規ビタミンD誘導体の有用性2010
- Author(s)
  松本直樹、榊利之、橘高敦史, 他3名
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] CYP105A1二重変異体によるビタミンD_3の代謝とその反応機構2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之, 他5名
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis of 4-substituted chiral PNA monomers2010
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, Atsushi Kittaka
- Organizer
  5^<th> International peptide Symposium
- Place of Presentation
  国立京都国際会館、京都
- Data Source
  KAKENHI-PROJECT-20590099
[Presentation] ペプチド核酸-金属錯体コンジュゲートによるDNA切断2010
- Author(s)
  杉山亨、二宮啓子、今村保忠、栗原正明、高野真史、橘高敦史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ、岡山
- Data Source
  KAKENHI-PROJECT-20590099
[Presentation] Novel C15-Substituted Active Vitamin D_3 Analogs : Design, Synthesis and Biological Activity2009
- Author(s)
  K Shindo, M Takano, G Kumagai, N Saito, H Saito, K Takagi, S Kakuda, M Takimoto-Kamimura, K Takenouchi, S Ishizuka, D Sawada, A Kittaka
- Organizer
  14th Vitamin D Workshop
- Place of Presentation
  Brugge, Belgium
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 活性型ビタミンD_3誘導体における核内受容体 Water Channel の維持と生物活性2009
- Author(s)
  高野真史, 澤田大介, 林恵子, 生城真一, 榊利之, 角田真二, 高木健一郎, 堀江恭平, 上村みどり, 竹之内一弥, 杉浦隆之, 野尻久雄, 橘高敦司
- Organizer
  日本ビタミン学会第61回大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 2位置換型ビタミンDラクタム(DLAM)誘導体の合成研究とその生物活性評価2009
- Author(s)
  東邦瑠衣、阿部純子、宇根内史、中村優子、齋藤博、落合鋭士、高木健一郎、石塚誠一、滑川淳一、橘高敦史、竹之内一弥、長澤和夫
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  日大・理工・船橋
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 2位側鎖上に複素環を有する活性型ビタミンD_3の合成2009
- Author(s)
  長谷川麻美、高野真史、中村優子、齋藤博、高木健一郎、堀江恭平、竹之内一弥、澤田大介、橘高敦史
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 核内受容体Water Channel を維持する2α置換活性型ビタミンD_32009
- Author(s)
  高野真史、澤田大介、林恵子、生城真一、榊利之、角田真二、高木健一郎、堀江恭平、上村みどり、石塚誠一、竹之内一弥、杉浦隆之、橘高敦史
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 2α側鎖上に複素環を有する活性型ビタミンD_3誘導体の合成と生物活性2009
- Author(s)
  松尾実紀, 長谷川麻美, 高野真史, 中村優子, 齋藤博, 角田真二, 高木健一郎, 落合鋭士, 堀江恭平, 上村みどり, 竹之内一弥, 澤田大介, 橘高敦史
- Organizer
  第39回複素環化学討論会
- Place of Presentation
  柏
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis and Preliminary Biological Eveluation of New 14-Epi-Previtamin D_3 and Its 19-Nor-Analogs with 2-Modification2009
- Author(s)
  D Sawada, Y Tsukuda, N Saito, T Katayama, M Takano, H Saito, K Takagi, S Kakuda, M Takimoto-Kamimura, K Takenouchi, S Ishizuka, A Kittaka
- Organizer
  14th Vitamin D Workshop
- Place of Presentation
  Brugge, Belgium
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Novel Calcitriol Derivatives : Design, Synthesis, and Preliminary Biological Evaluation2009
- Author(s)
  Atsushi Kittaka
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  九州大学医学部百年記念講堂
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] 4位に置換基を導入した14-エピ-プレビタミンD_3の合成と生物活性評価2009
- Author(s)
  佃勇也、澤田大介、齋藤博、高木健一郎、堀江恭平、竹之内一弥、橘高敦史
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンD受容体の強力なアゴニストとアンタゴニストの設計と合成2009
- Author(s)
  橘高敦史
- Organizer
  研究成果発表フォーラム
- Place of Presentation
  東京ビッグサイト
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] 新規活性型ビタミンD_3誘導体の設計と合成:核内受容体リガンド結合領域との相互作用2009
- Author(s)
  橘高敦史
- Organizer
  神戸薬科大学大学院講演会
- Place of Presentation
  神戸薬科大学
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] ビタミンD誘導体合成とビタミンD受容体リガンド結合領域での相互作用と生物活性:水分子にも着目して2009
- Author(s)
  橘高敦史
- Organizer
  第5回帝人VD3研究会帝人ファーマ株式会社生物医学総合研究所主催
- Place of Presentation
  日野市(富士電機研修室)
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-21590022
[Presentation] 活性型ビタミンD_3誘導体における核内受容体Water Channelの維持と生物活性2009
- Author(s)
  高野真史, 澤田大介, 林恵子, 生城真一, 榊利之, 橘高敦司(他7名)
- Organizer
  日本ビタミン学会第61回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Synthesis and Preliminary Biological Eveluation of New 14-Epi-Previtamin D_3 and Its 19-Nor-Analogs with 2-Modification2009
- Author(s)
  D Sawada, Y, A Kittaka(他10名)
- Organizer
  14th Vitamin D Workshop
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Novel C15-Substituted Active Vitamin D_3 Analogs : Design, Synthesis and Biological Activity2009
- Author(s)
  K Shindo, M Takano, G Kumagai, N Saito, H Saito, K Takagi, S Kakuda, M Takimoto-Kamimura, K Takenouchi, S Ishizuka, D Sawada and A Kittaka
- Organizer
  14th Vitamin D Workshop
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ペプチド核酸-金属錯体コンジュゲートによる配列特異的DNA切断2009
- Author(s)
  杉山亨、二宮啓子、今村保忠、栗原正明、高野真史、橘高敦史
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州国際会議場、福岡
- Data Source
  KAKENHI-PROJECT-20590099
[Presentation] Synthesis and Biological Evaluation of Novel 2-Substituted 14- epi-Previtamin D_3 Analogs2008
- Author(s)
  Daisuke Sawada, Yuya Tsukuda, Nozomi Saito, Tomoyuki Katayama, Hiroshi Saito, Ken-ichiro Takagi, Kazuya Takenouchi, Seiichi Ishizuka, Midori Takimoto-Kamimura, Masashi Takano, Atsushi Kittaka
- Organizer
  第236回アメリカ化学会
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 活性型ビタミンD_3誘導体の合成と生物活性 : 2位修飾、CD環修飾2008
- Author(s)
  橘高敦史
- Organizer
  第4回帝人VD3研究会
- Place of Presentation
  帝人生物医学総合研究所
- Year and Date
  2008-06-02
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 2位置換14-エピプレビタミンD_3誘導体の合成と活性評価2008
- Author(s)
  橘高敦史, ら
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 新規4位置換14-エピプレビタミンD_3の合成2008
- Author(s)
  橘高敦史, ら
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシヒコ横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] VDR及び変異VDRに作用するノンセコ型リガンドの設計と合成2008
- Author(s)
  金子文也、佐藤由紀子、岩井すみれ、本澤忍、山下純、橘高敦史、加藤茂明、奥田晴宏、栗原正明
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] New Vitamin D_3 Analogs : 2α-(2,3-Dihydroxypropoxy)-and 2α-(2-Hydroxypropoxy)- Active Vitamin D_3 with Highly Potent VDR Agonism2008
- Author(s)
  Masashi Takano, Daisuke Sawada, Keiko Hayashi, Shin-ichi Ikushiro, Toshiyuki Sakaki, Ken-ichiro Takagi, Seiichi Ishizuka, Midori Takimoto-Kamimura, Maiko Gokoh, Takayuki Sugiura, Atsushi Kittaka
- Organizer
  第236回アメリカ化学会
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Cooperative Strand Invasion by Peptide Nucleic Acid2008
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Masaaki Kurihara, Atsushi Kittaka
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 活性型ビタミンD_3の2α位の構造修飾とVDR リガンド結合領域に存在する水分子(water channel)との相互作用と生物活性2008
- Author(s)
  高野真史、澤田大介、杉浦隆之、橘高敦史、角田真二、高木健一郎、上村みどり、石塚誠一、竹之内一弥、林恵子、生城真一、榊利之
- Organizer
  第321回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京農業大学
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ヒト前立腺由来PZ-HPV-7 細胞におけるビタミンD_3誘導体の細胞増殖抑制作用および代謝2008
- Author(s)
  中林佐知栄、鎌倉昌樹、池田進之介、荒井緑、橘高敦史、楠堂達哉、山下均、太田美穂、生城真一、榊利之
- Organizer
  日本ビタミン学会第60回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 14-エピプレビタミンD_3への4位置換基の導入2008
- Author(s)
  佃勇也、澤田大介、高木健一郎、石塚誠一、橘高敦史
- Organizer
  日本ビタミン学会第60回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Structure-Activity Relationship Study on Vitamin D Receptor Antagonist TEI-9647 Analogs2008
- Author(s)
  Nozomi Saito, Manami Masuda, Toshihiro Matsunaga, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, Jun-ichi Namekawa, Seiichi Ishizuka, Midori Takimoto-Kamimura, Atsushi Kittaka
- Organizer
  第236回アメリカ化学会
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Efficient Synthesis of 2α-(3-Hydroxypropyl)-1α,25-dihydroxy-19-norvitamin D_3 (MART-10) with Julia Olefination2008
- Author(s)
  Atsushi Kittaka
- Organizer
  Meeting on Vitamin D Analogs : MART-10
- Place of Presentation
  神田学士会館
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 14-epi-Previtamin D_3誘導体の合成とGenomic作用2008
- Author(s)
  澤田大介、佃勇也、高野真史、橘高敦史、齋藤博、高木健一郎、落合鋭士、竹之内一弥
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 活性型ビタミンD_3の2α置換と核内受容体Water Channel2008
- Author(s)
  高野真史、澤田大介、杉浦隆之、橘高敦史、林恵子、生城真一、榊利之、角田真二、高木健一郎、上村みどり、竹之内一弥、石塚誠一
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 2位置換型ビタミンDラクタム(DLAM)誘導体の合成と生物活性評価2008
- Author(s)
  阿部純子、宇根内史、東邦瑠衣、中村優子、齋藤博、落合鋭士、高木健一郎、石塚誠一、滑川淳一、橘高敦史、竹之内一弥、長澤和夫
- Organizer
  第19回日本レチノイド研究会
- Place of Presentation
  東京慈恵会医大
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 2α-(2-hydroxypropoxy)-1α,25-dihydroxyvitamin D_3 の合成と生物活性評価2008
- Author(s)
  高野真史、澤田大介、林恵子、生城真一、榊利之、高木健一郎、石塚誠一、杉浦隆之、橘高敦史
- Organizer
  日本ビタミン学会第60回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Seco-ステロイド骨格の構造展開と核内受容体を介する生物活性(受賞講演)2008
- Author(s)
  橘高敦史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 2位置換14-エピプレビタミンD_3誘導体の合成と活性評価2008
- Author(s)
  澤田大介、佃勇也、片山智之、齋藤望、齋藤博、竹之内一弥、高木健一郎、滑川淳一、石塚誠一、橘高敦史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 協同的ストランドインベージョンによる二本鎖DNA 内18塩基の厳密な認識2008
- Author(s)
  杉山亨、今村保忠、栗原正明、橘高敦史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 新しいseco-ステロイド骨格の修飾部位 : 15位置換活性型ビタミンD_3の合成と生物活性2008
- Author(s)
  新藤香菜子、高野真史、齋藤望、齋藤博、高木健一郎、竹之内一弥、石塚誠一、澤田大介、橘高敦史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 2α置換基に不斉炭素を有する新規ビタミンD_3誘導体の合成と生物活性評価2008
- Author(s)
  高野真史、澤田大介、林恵子、生城真一、榊利之、高木健一郎、石塚誠一、岸本成史、杉浦隆之、橘高敦史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Vitamin D hormone : structural refinement of the secosteroidal skeleton and the nuclear receptor mediated biological activity2008
- Author(s)
  Atsushi Kittaka, Daisuke Sawada, Masashi Takano, Nozomi Saito, Tomoyuki Katayama, Kanako Shindo, Yuya Tsukuda, Shinobu Honzawa, Midori A. Arai, Hiroshi Saito, Ken-ichiro Takagi, Kazuya Takenouchi, Seiichi Ishizuka, Toshiyuki Sakaki, and Tai C. Chen
- Organizer
  3rd Symposium Vitamin D Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Krefeld, Germany
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 19-Nor-2α-(3-hydroxypropyl)-1α,25-Dihydroxyvitamin D_3 Has Enhanced Chemotherapeutic Potency in Prostate Cancer Cells2008
- Author(s)
  J. N. Flanagan, A. Kittaka, T. Sakaki, Y. F. Lee, M. F. Holick, T. C. Chen
- Organizer
  3rd Symposium Vitamin D Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Krefeld, Germany
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンDレセプターノンセコ型リガンドの設計と合成2008
- Author(s)
  金子文也、佐藤由紀子、袴田航、奥田晴宏、本澤忍、山下純、杉浦隆之、橘高敦史、加藤茂明、栗原正明
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 前立腺細胞PZ-HPV-7 におけるビタミンD_3誘導体の代謝及び増殖抑制作用メカニズムの解明2008
- Author(s)
  中林佐知栄、池田進之介、林恵子、生城真一、鎌倉昌樹、荒井緑、橘高敦史、TaiC. Chen、太田美穂、榊利之
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Seco-ステロイド骨格の構造展開と核内受容体を介する生物活性(宮田賞受賞講演)2008
- Author(s)
  橘高敦史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 新規4位置換14-エピプレビタミンD_3の合成2008
- Author(s)
  佃勇也、澤田大介、高木健一郎、石塚誠一、橘高敦史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] New Vitamin D_3 Analogs : 2alpha-(2, 3-Dihydroxypropoxy)- and 2alpha-(2-Hydroxypropoxy)-Active Vitamin D_3 with Highly Potent VDR Agonism2008
- Author(s)
  Atsushi Kittakaら
- Organizer
  第236回アメリカ化学会
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンDホルモン : 2α置換と核内受容体water channel2008
- Author(s)
  橘高敦史
- Organizer
  薬学部セミナー
- Place of Presentation
  帝京大学薬学部
- Year and Date
  2008-06-18
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 活性型ビタミンD_3の2α位の構造修飾とVDRリガンド結合領域に存在する水分子(water channel)との相互作用と生物活性2008
- Author(s)
  橘高敦史
- Organizer
  第321回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京農業大学
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Vitamin D Hormone : Structural Refinement of the seco-Steroidal Skeleton and the Nuclear Receptor Mediated Biological Activity2008
- Author(s)
  Atsushi Kittaka
- Organizer
  3rd Sympos ium Vi tamin D Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Krefeld, Germany
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ペプチド核酸による協同的ストランドインベージョン2008
- Author(s)
  杉山亨、今村保忠、栗原正明、橘高敦史
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  タワーホール船堀、東京
- Data Source
  KAKENHI-PROJECT-20590099
[Presentation] 2α-(2,3-Dihydroxypropoxy)-1α,25-dihydroxyvitamin D_3の合成と生物活性評価2007
- Author(s)
  高野真史、澤田大介、林恵子、生城真一、榊利之、高木健一郎、石塚誠一、岸本成史、杉浦隆之、橘高敦史
- Organizer
  日本ビタミン学会第59回大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 14-epi-Previtamin D_3 誘導体の合成とその生物活性 : Genomic作用とnon-genomic作用の分岐点2007
- Author(s)
  澤田大介、佃勇也、片山智之、齋藤望、橘高敦史、齋藤博、高木健一郎、滑川淳一、竹之内一弥、石塚誠一
- Organizer
  第33回反応と合成の進歩シンポジウム
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 14-エピ-プレビタミンD_3の構造修飾と生物活性2007
- Author(s)
  澤田大介、佃勇也、片山智之、齋藤望、齋藤博、高木健一郎、滑川淳一、竹之内一弥、石塚誠一、橘高敦史
- Organizer
  第51回日本薬学会関東支部大会
- Place of Presentation
  星薬科大学
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ノンセコ型VDR リガンドの設計と合成2007
- Author(s)
  栗原正明、佐藤由紀子、金子文也、袴田航、本澤忍、山下純、橘高敦史、加藤茂明、奥田晴宏
- Organizer
  第26回メディシナルケミストリーシンポジウム
- Place of Presentation
  相模原
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] キラルな2α置換基を有するビタミンD_3誘導体の合成と生物活性評価2007
- Author(s)
  高野真史、澤田大介、林恵子、生城真一、榊利之、高木健一郎、石塚誠一、岸本成史、杉浦隆之、橘高敦史
- Organizer
  第26回メディシナルケミストリーシンポジウム
- Place of Presentation
  相模原
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 活性型ビタミンD_3誘導体2007
- Author(s)
  橘高敦史
- Organizer
  第2回京都会議
- Place of Presentation
  京大会館
- Year and Date
  2007-12-27
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] seco-ステロイド骨格の構造展開と核内受容体を介する生物活性2007
- Author(s)
  橘高敦史
- Organizer
  九州大学大学院薬学研究院
- Place of Presentation
  九州大学
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンD受容体を介する生物活性の多様性 : 新規セコステロイド骨格による強力なアゴニスト作用、アンタゴニスト作用、およびコアクチベータ選択性の検討2007
- Author(s)
  橘高敦史
- Organizer
  国立医薬品食品衛生研究所特別講演
- Place of Presentation
  国立医薬品食品衛生研究所
- Year and Date
  2007-11-13
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 活性型ビタミンD_3誘導体の2α置換基上の立体化学と生物活性について2007
- Author(s)
  高野真史、澤田大介、林恵子、生城真一、榊利之、高木健一郎、石塚誠一、岸本成史、杉浦隆之、橘高敦史
- Organizer
  第18回日本レチノイド研究会
- Place of Presentation
  東京大学武田ホール
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Recognition of Longer Duplex DNA by Cooperative Strand Invasion2007
- Author(s)
  Toru Sugiyama, Yasutada Imamura, Masaaki Kurihara, Atsushi Kittaka
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学安田講堂
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 活性型ビタミンD_3誘導体2007
- Author(s)
  橘高敦史
- Organizer
  第2回ビタミンD京都会議
- Place of Presentation
  京大会館
- Year and Date
  2007-12-27
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] キラルな2α置換基を有するビタミンD_3誘導体の合成と生物活性評価2007
- Author(s)
  橘高敦史, ら
- Organizer
  第26回メディシナルケミストリーシンポジウム
- Place of Presentation
  グリーンホール相模大野
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンD受容体を介する生物活性の多様性:新規セコステロイド骨格による強力なアゴニスト作用、アンタゴニスト作用、およびコアクチベータ選択性の検2007
- Author(s)
  橘高敦史
- Organizer
  国立医薬品食品衛生研究所特別講演
- Place of Presentation
  国立医薬品食品衛生研究所
- Year and Date
  2007-11-13
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] seco-ステロイド骨格の構造展開と核内受容体を介する生物活性2007
- Author(s)
  橘高敦史
- Organizer
  九州大学大学院薬学研究院講演
- Place of Presentation
  九州大学大学院薬学研究院
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 14-エビ-プレビタミンD_3の構造修飾と生物活性2007
- Author(s)
  橘高敦史, ら
- Organizer
  第51回日本薬学会関東支部大会
- Place of Presentation
  星薬科大学
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 14-eprPrevitamin D_3誘導体の合成とその生物活性: Genomic作用とnon-genomic作用の分岐点2007
- Author(s)
  橘高敦史, ら
- Organizer
  第33回反応と合成の進歩シンポジウム
- Place of Presentation
  長崎ブリックホール
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンDと骨2007
- Author(s)
  橘高敦史
- Organizer
  第1回ビタミンD京都会議
- Place of Presentation
  京大会館
- Year and Date
  2007-08-21
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] A環修飾14-eprビタミンD_3と14-epr-19-ノルビタミンD_3誘導体の合成と生物活2007
- Author(s)
  橘高敦史, ら
- Organizer
  第316回脂溶性ビタミン総合研究委員会
- Place of Presentation
  同志社大学京田辺キャンパス
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 2α-(2,3Dihydroxypropoxy)-1α,25-dihydroxyvitamin D_3の合成と生物活性評価2007
- Author(s)
  橘高敦史, ら
- Organizer
  日本ビタミン学会第59回大会
- Place of Presentation
  ハウステンボス(長崎)
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Synthesis of New 14-epr-Previtamin D_3 Analogs: Effect of C2-Modification on Biological Activity(受賞発表)2007
- Author(s)
  橘高敦史, ら
- Organizer
  The 14th Annual Providence Symposium on Vitamin D
- Place of Presentation
  ブラウン大学(米国ロードアイランド州)
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンD骨格への2位置換のさらなる適用拡大:不斉炭素を持つ2α置換基の導入と2位置換14-エピプレビタミンD_3の合成研究2007
- Author(s)
  橘高敦史
- Organizer
  第3回帝人VD研究会
- Place of Presentation
  帝人ファーマ株式会社創薬研究所(東京)
- Year and Date
  2007-06-18
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンD骨格への2位置換のさらなる適用拡大 : 不斉炭素を持つ2α置換基の導入と2位置換14-エピプレビタミンD_3の合成研究2007
- Author(s)
  橘高敦史
- Organizer
  第3回帝人VD3研究会
- Place of Presentation
  帝人ファーマ株式会社生物医学総合研究所
- Year and Date
  2007-06-18
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] Synthesis of New 14- epi-Previtamin D_3 Analogs : Effect of C2-Modification on Biological Activity(Brown University Vitamin D Research Award 受賞発表)2007
- Author(s)
  Daisuke Sawada, Nozomi Saito, Tomoyuki Katayama, Yuya Tsukuda, Masashi Takano, Hiroshi Saito, Ken-ichiro Takagi, Kazuya Takenouchi, Seiichi Ishizuka, Midori Takimoto-Kamimura, Atsushi Kittaka
- Organizer
  The 14th Annual Providence Symposium on Vitamin D
- Place of Presentation
  Brown University
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] A環修飾14-epi-ビタミンD_3と14-epi-19-ノルビタミンD_3誘導体の合成と生物活性2007
- Author(s)
  澤田大介、齋藤望、片山智之、佃勇也、原英己、高野真史、橘高敦史、齋藤博、高木健一郎、千田貴之、原田善史、竹之内一弥、上村みどり、石塚誠一、Tai C.Chen
- Organizer
  第316回脂溶性ビタミン総合研究委員会
- Place of Presentation
  同志社大学
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] ビタミンDと骨2007
- Author(s)
  橘高敦史
- Organizer
  第1回京都会議
- Place of Presentation
  京大会館
- Year and Date
  2007-08-21
- Data Source
  KAKENHI-PROJECT-19590016
[Presentation] 強い骨密度上昇作用を有するビタミンD誘導体の代謝様式の解明
- Author(s)
  遠山枝李、安田佳織、生城真一、鎌倉昌樹、高野真史、橘高敦史、榊　利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05 – 2015-06-06
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2α位にトリアゾリルプロピル基を有する19-ノル型ビタミンD3の合成と生物活性評価
- Author(s)
  高野真史，樋口恵理香，安田佳織，榊　利之，橘高敦史
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05 – 2015-06-06
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] SYNTHESIS, METABOLISM, AND BIOLOGICAL ACTIVITY OF 2-[3-(TETRAZOLYL)PROPYL]- 1α,25-DIHYDROXY-19-NORVITAMIN D3
- Author(s)
  M. Takano, E. Higuchi, K. Yasuda, E. Tohyama, A. Takeuchi, T. Sakaki, and A. Kittaka
- Organizer
  18th Vitamin D Workshop
- Place of Presentation
  デルフト市、オランダ
- Year and Date
  2015-04-21 – 2015-04-24
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 分割型ルシフェラーゼを用いたビタミンDバイオセンサーの開発
- Author(s)
  真野寛生、西川美宇、安田佳織、鎌倉昌樹、生城真一、　高野真史、斉藤　望、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05 – 2015-06-06
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] デアザグアニン誘導体を持つPNA モノマーの合成
- Author(s)
  杉山亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2α-(3-ヒドロキシプロピル)活性型ビタミンD3（MART-10）の合成と制がん活性
- Author(s)
  高野真史，Kun-Chun Chiang，安田佳織，榊利之，Tai C. Chen，橘高敦史
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2-(3-トリアゾリルプロピル)-1α,25(OH)2-19-ノルビタミンD3の合成
- Author(s)
  高野真史，谷川有梨紗，小川圭瞳，宮田英美，上坂博翔，阪本祥一，橘高敦史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2位にテトラゾリルプロピル基を有する19-ノル活性型ビタミンD3の合成と代謝
- Author(s)
  樋口恵理香，安田佳織，高野真史，榊　利之，橘高敦史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 8,9-ジヒドロ-19-ノルタキステロール誘導体の合成と生物活性評価
- Author(s)
  松本洋太郎、澤田大介、竹内明子、橘高敦史
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  東北大・萩ホール
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] Modified Deazaguanines for the Synthesis of PNA
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] メチルステロール酸化酵素SC4MOLによる2位置換基付加型ビタミンD誘導体の代謝
- Author(s)
  安田佳織、岩永由麻、小川和亮、生城真一、鎌倉昌樹、高野真史、齋藤　望、橘高敦史、藤島利江、太田美穂、榊　利之
- Organizer
  日本ビタミン学会第66回大会
- Place of Presentation
  姫路商工会議所
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] MART-10 Has Enhanced Chemotherapeutic Potency- in vitro and in vivo Pre-clinical Studies
- Author(s)
  K.C. Chiang, A. Kittaka, J.N. Flanagan, T. Sakaki, G. Norstedt and T.C. Chen
- Organizer
  5th International Symposium Vitamin D and Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Krefeld, Germany
- Year and Date
  2014-05-02 – 2014-05-03
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2α-ヘテロアリールプロピル-19-ノルビタミンD3の合成と生物活性評価
- Author(s)
  高野真史、樋口恵理香、廣瀬七帆、竹内明子、澤田大介、橘高敦史
- Organizer
  第44回複素環化学討論会
- Place of Presentation
  札幌市民ホール
- Year and Date
  2014-09-10 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 2α位にテトラゾールプロピル基を有する19-ノル型ビタミンD3の合成と生物活性評価
- Author(s)
  高野真史、樋口恵理香、竹内明子、澤田大介、橘高敦史
- Organizer
  日本ビタミン学会第66回大会
- Place of Presentation
  姫路商工会議所
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1α,2α,25-, 1α,4α,25- AND 1α,4β,25-TRIHYDROXYVITAMIN D3 WITH METABOLIC STUDIES
- Author(s)
  M. Takano, D. Sawada, K. Yasuda, M. Nishikawa, A. Takeuchi, K. Takagi, K. Horie, G.S. Reddy, T.C. Chen, T. Sakaki, and A. Kittaka
- Organizer
  17th Vitamin D Workshop
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-06-17 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] Pre-clinical Studies of MART-10, a Less Calcemic Vitamin D Analog, for Cancer Prevention and Treatment
- Author(s)
  Tai C Chen, Kun-Chun Chiang, and Atsushi Kittaka
- Organizer
  Translational Science 2014 Annual Meeting
- Place of Presentation
  Omni Shoreham Hotel, Washington DC, USA
- Year and Date
  2014-04-09 – 2014-04-11
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] PNA合成のための修飾デアザグアニン
- Author(s)
  杉山　亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  第５１回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス大塚講堂（徳島県徳島市）
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24590135
[Presentation] デアザグアニン誘導体を持つPNAモノマーの合成
- Author(s)
  杉山　亨、桑田啓子、今村保忠、出水庸介、栗原正明、高野真史、橘高敦史
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590135

1. SUGIYAMA Toru (40242036)

# of Collaborated Projects : 8results

# of Collaborated Products : 50results
2. TAKANO Masashi (50386611)

# of Collaborated Projects : 6results

# of Collaborated Products : 125results
3. NOZOMI Saito (80349258)

# of Collaborated Projects : 3results

# of Collaborated Products : 19results
4. SAWADA Daisuke (00338691)

# of Collaborated Projects : 3results

# of Collaborated Products : 57results
5. SAKAKI Toshiyuki (70293909)

# of Collaborated Projects : 3results

# of Collaborated Products : 67results
6. FUJISHIMA Toshie (90286980)

# of Collaborated Projects : 3results

# of Collaborated Products : 12results
7. SUHARA Yoshitomo (30297171)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. YOSHIDA Akihiro (10292301)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. HONZAWA Shinobu (90311547)

# of Collaborated Projects : 2results

# of Collaborated Products : 10results
10. ARAI Midori (40373261)

# of Collaborated Projects : 2results

# of Collaborated Products : 8results
11. SUGIMOTO Hiroshi (90344043)

# of Collaborated Projects : 1results

# of Collaborated Products : 7results
12. IKUSHIRO Shinichi (50244679)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
13. TAKAYAMA Hiroaki (00012609)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 中川公恵 (90309435)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. Yasuda kaori

# of Collaborated Projects : 0results

# of Collaborated Products : 5results
16. Naito Mikihiko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. 谷内出友美

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
18. 出水庸介

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
19. 三澤隆史

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
20. 大岡伸通

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
21. 加納健司

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

KITSUTAKA ATSUSHI 橘高 敦史

KITTAKA Atsushi 橘高 敦史

Research Projects

Research Products

Co-Researchers

Elongation of half-life time of vitamin D receptor ligands: acquisition of metabolic resistance and development of selective inhibitors against inactivation enzyme of vitamin DPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲノム編集法 により作製した遺伝子改変ラットを用いたビタミンD誘導体評価系の構築Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ビタミンＤ由来光反応異性体の新規構造展開：骨作用増強と生体内半減期増長分子の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study and development of a 14-epi-tachysterol skeleton and enhancing bone formation via flexibility of ligand binding domain of vitamin D receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and synthesis of chiral peptide nucleic acid for antigene therapeutics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Protein Engineering of vitamin D hydroxylases and design of their inhibitors based on their tertiary structure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on structural development of novel 14-epi-19-norprevitamin D type seco-steroids working on bone formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and development of antigene agents based on strand invasion mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

14-epi-Previtamin D Analogs : Design and Synthesis of Selective Ligands for Nuclear Receptor and Membrane ReceptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of selective nuclear receptor modulators with a 2,25-modified seco-steroidal skeletonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and Synthesis of Vitamin D Receptor Antagonists : Remedy for Pagets DeseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DMA Lesions on the Specific Site in the Transcription Factor Binding Domain with RecA-Oligonucleotide ComplexesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Organic Chemical Creation of Substances with Novel Function and Its Application

Principal Investigator

Project Period (FY)

KITSUTAKA ATSUSHI 橘高敦史

KITTAKA Atsushi 橘高敦史

ゲノム編集法により作製した遺伝子改変ラットを用いたビタミンD誘導体評価系の構築Ongoing

[Book] スタンダード薬学シリーズⅡ ３　化学系薬学Ⅲ.「自然が生み出す薬物」2016

[Book] スタンダード薬学シリーズⅡ ３　化学系薬学Ⅱ.「生体分子・医薬品の化学による理解」2016

[Book] スタンダード薬学シリーズⅡ ３　化学系薬学Ⅰ.「化学物質の性質と反応」2015