SAKAKI Toshiyuki 榊利之

Researcher Number	70293909
Other IDs
External Links
Affiliation (Current)	2021: 富山県立大学, 工学部, 研究員
Affiliation (based on the past Project Information) *help	2008 – 2020: Toyama Prefectural University, 工学部, 教授 2010: 富山県立大, 工学部, 教授 2004 – 2005: 富山県立大学, 工学部, 教授 1999 – 2003: 京都大学, 農学研究科, 助教授 1999: 京都大学, 大学院・農学研究科, 助教授 1997: Kyoto University, Faculty of Agriculture, Associate Professor, 農学部, 助教授
Review Section/Research Field	Principal Investigator Applied biochemistry / General physiology / 応用微生物学・応用生物化学 / Science and Engineering / Basic Section 38030:Applied biochemistry-related Except Principal Investigator Food science / Functional biochemistry / Living organism molecular science / Chemical pharmacy / Human genetics / 応用微生物学・応用生物化学 / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator ビタミンD / シトクロムP450 / 癌 / シグナル伝達 / 骨粗鬆症 / ビタミンD受容体 / 部位特異的変異導入 / 遺伝子 / ビタミンD水酸化酵素 / 高感度検出系 … More Except Principal Investigator 亜鉛酵素 / ポリフェノール / ＵＤＰ-グルクロン酸転移酵素 / 硫酸基転移酵素 / ビタミンD / メタロプロテイナーゼ / 金属酵素 / 細胞外マトリックス / 酵素反応機構 / 癌の転移と浸潤 / チロシン / プロテアーゼ / メタロプロテアーゼ / カテキン / リグナン / 酵素阻害剤 / ガン転移 / 化学修飾 / 食品生化学 / 食品代謝物 / フラボノイド / グルクロン酸転移酵素 / シトクロムP450 / 食品 / バイオテクノロジー / 異物代謝 / 代謝酵素 / CYP / ケミカルゲノミクス / 基質認識 / 代謝物予測システム / 構造活性相関 / ケミカル・ゲノミクス / 機能性成分 / グルクロン酸抱合 / 硫酸抱合 / 国際情報交換、フィンランド / 国際情報交流、フィンランド / 薬学 / 有機化学 / 合成化学 / 骨粗鬆症治療薬 / タキステロール / 生物活性 / ビタミンD受容体 / 生体分子 / 生理活性 / 抱合代謝物 / 出芽酵母 / UDP-グルクロン-酸転移酵素 / メチル基転移酵素 / Caco2細胞 / 共培養系 / 酵母 / 代謝物調製 / UDP-グルクロン酸転移酵素 / 硫酸転移酵素 / 肝癌 / 遺伝子治療 / ベクター / アデノウイルス / AFPプロモーター / アデノウイルスベクター / Cre / loxp / Hepatocarcinoma / Gene therapy / Vector / Adenovirus / AFP promoter / 蛋白質工学 / 部位特異的変異導入 / 金属プロテイナーゼ / サーモライシン / マトリライシン / アスパルテーム / 好塩性酵素 / 酵素活性 / 酵素の安定性 / 金属プロテアーゼ / 好熱性酵素 / 塩類 / protein engineering / site-directed mutagenesis / metalloproteinase / thermolysin / matrilysin / aspartame / halophilic enzyme / enzyme activity / 炎症性腸疾患 Less

ビタミンDの消化管炎症に対する関りと新規炎症性腸疾患治療戦略Ongoing
- Principal Investigator
  
  岡田只士
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Toyama Prefectural University
Elucidation of vitamin D actions using genetically modified rats and application of vitamin D analogs to medical drugsPrincipal InvestigatorOngoing
- Principal Investigator
  
  榊利之
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Toyama Prefectural University
Construction of evaluation system for vitamin D analogs using genetically modified rats with genome editingPrincipal Investigator
- Principal Investigator
  
  SAKAKI TOSHIYUKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University
Development of highly sensitive detection system for active form of vitamin DPrincipal Investigator
- Principal Investigator
  
  Toshiyuki Sakaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University
The high-level usage of metabolites of dietary compounds for elucidating the molecular mechanism of functional foods
- Principal Investigator
  
  Ikushiro Shinichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Toyama Prefectural University
Advanced use of vitamin D hydroxylasesPrincipal Investigator
- Principal Investigator
  
  SAKAKI TOSHIYUKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University
Study and development of a 14-epi-tachysterol skeleton and enhancing bone formation via flexibility of ligand binding domain of vitamin D receptor
- Principal Investigator
  
  KITTAKA Atsushi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
Whole cell-dependent production of polyphenol conjugates using genetically engineered budding yeast
- Principal Investigator
  
  IKUSHIRO Shinichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Toyama Prefectural University
Mechanism of substrate recognition by cytochrome p450s and application to in silico prediction system of metabolites of drug candidates
- Principal Investigator
  
  AKAMATSU Miki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University
25-ヒドロキシビタミンD3のホルモン作用の解析Principal Investigator
- Principal Investigator
  
  榊利之
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Toyama Prefectural University
Protein Engineering of vitamin D hydroxylases and design of their inhibitors based on their tertiary structurePrincipal Investigator
- Principal Investigator
  
  SAKAKI Toshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University
Construction of evaluation system of metabolism for dietary compounds using human xenobiotic enzymes
- Principal Investigator
  
  IKUSHIRO Shinichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Toyama Prefectural University
Ahレセプターの生理的意義と内在性リガンドの生成機構Principal Investigator
- Principal Investigator
  
  榊利之
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Toyama Prefectural University
Construction of evaluation system for vitamin D analogsPrincipal Investigator
- Principal Investigator
  
  SAKAKI Toshiyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University
内分泌攪乱物質代謝能を有する微生物の創製Principal Investigator
- Principal Investigator
  
  榊利之
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
マトリックスメタロプロテイナーゼ-7の構造と機能の分子論的解析および阻害剤の開発
- Principal Investigator
  
  井上國世
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyoto University
METABOLISM OF VITAMIN D ANALOGS BY HUMAN ENZYMESPrincipal Investigator
- Principal Investigator
  
  SAKAKI Toshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  KYOTO UNIVERSITY
Molecular mechanism, protein engineering, and application of a thermophilic and halophilic enzyme, thermolysin
- Principal Investigator
  
  INOUYE Kuniyo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  KYOTO UNIVERSITY
Studies on vitamin D hydroxylasesPrincipal Investigator
- Principal Investigator
  
  SAKAKI Toshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  KYOTO UNIVERSITY
Development of a gene therapy vector bearing a swiching mechanism of gene expression
- Principal Investigator
  
  SAITO Izumu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human genetics
- Research Institution
  The University of Tokyo

[Book] Vitamin D Hormone2016
- Author(s)
  Eiji Munetsuna, Atsushi Kittaka, Tai C Chen, and Toshiyuki Sakaki
- Total Pages
  21
- Publisher
  UK: Academic Press
- Data Source
  KAKENHI-PROJECT-25292062
[Book] ビタミンDと疾患　(ビタミンDの代謝：ｐｐ60-68）2014
- Author(s)
  榊　利之
- Total Pages
  246
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-25292062
[Book] Fifty Years of Cytochrome P450 Research2014
- Author(s)
  S.Ikushiro, M. Nishikawa, T. Sakaki
- Total Pages
  409
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-26292072
[Book] ビタミン総合事典2010
- Author(s)
  榊利之、橘高敦史(他158名)
- Total Pages
  624
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21380067
[Book] ビタミン総合事典2010
- Author(s)
  榊利之, 橘高敦史, 他158名
- Total Pages
  624
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21380067
[Book] ビタミン総合事典2010
- Author(s)
  榊利之, (他159名)
- Total Pages
  624
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-22659043
[Book] ビタミン 83(ヒトグルクロン酸転移酵素分子種によるケルセチン抱合代謝)2009
- Author(s)
  生城真一、鎌倉昌樹、榊利之
- Data Source
  KAKENHI-PROJECT-20580138
[Journal Article] Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring2020
- Author(s)
  Milczarek Magdalena、Chodynski Micha?、Pietraszek Anita、Stachowicz-Suhs Martyna、Yasuda Kaori、Sakaki Toshiyuki、Wietrzyk Joanna、Kutner Andrzej
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Pages: 642-642
- DOI
  10.3390/ijms21020642
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Journal Article] Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions2020
- Author(s)
  Nishikawa M, Yasuda K, Takamatsu M, Abe K, Okamoto K, Horibe K, Mano H, Nakagawa K, Tsugawa N, Hirota Y, Horie T, Hinoi E, Okano T, Ikushiro S, Sakaki T.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 1-12
- DOI
  10.1038/s41598-020-62048-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11056, KAKENHI-PROJECT-18KK0455, KAKENHI-PROJECT-19H02889
[Journal Article] Concise Synthesis of 23-Hydroxylated Vitamin D3 Metabolites2019
- Author(s)
  Kawagoe Fumihiro、Sugiyama Toru、Yasuda Kaori、Uesugi Motonari、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume: 186 Pages: 161-168
- DOI
  10.1016/j.jsbmb.2018.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-17K15261, KAKENHI-PLANNED-17H06408
[Journal Article] Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes2019
- Author(s)
  Nishikawa M, Yasuda K, Takamatsu M, Abe K, Nakagawa K, Tsugawa N, Hirota Y, Tanaka K, Yamashita S, Ikushiro S, Suda T, Okano T, Sakaki T
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 185 Pages: 71-79
- DOI
  10.1016/j.jsbmb.2018.07.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00895, KAKENHI-PROJECT-18K11056, KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-17K15261
[Journal Article] Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model2019
- Author(s)
  Nachliely Matan、Trachtenberg Aviram、Khalfin Boris、Nalbandyan Karen、Cohen-Lahav Merav、Yasuda Kaori、Sakaki Toshiyuki、Kutner Andrzej、Danilenko Michael
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 188 Pages: 8-16
- DOI
  10.1016/j.jsbmb.2018.11.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15261, KAKENHI-PROJECT-19K05829, KAKENHI-PROJECT-19H02889
[Journal Article] Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D3 Analogues2019
- Author(s)
  Kawagoe Fumihiro、Yasuda Kaori、Mototani Sayuri、Sugiyama Toru、Uesugi Motonari、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
  
  ACS Omega
  
  Volume: 4 Pages: 11332-11337
- DOI
  10.1021/acsomega.9b01500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-19K05829, KAKENHI-PROJECT-19H02889
[Journal Article] Introduction of fluorine atoms to vitamin D3 side-chain and synthesis of 24,24-difluoro-25-hydroxyvitamin D32019
- Author(s)
  Kawagoe Fumihiro、Mototani Sayuri、Yasuda Kaori、Nagasawa Kazuo、Uesugi Motonari、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 195 Pages: 105477-105477
- DOI
  10.1016/j.jsbmb.2019.105477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-19H02889
[Journal Article] ビタミンD 生成と代謝2018
- Author(s)
  榊　利之、安田　佳織
- Journal Title
  
  食と医療
  
  Volume: 5 Pages: 12-18
- Open Access
- Data Source
  KAKENHI-PROJECT-16H04912
[Journal Article] Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique2018
- Author(s)
  Hiroki Mano, Shinichi Ikushiro, Nozomi Saito, Atsushi Kittaka, and Toshiyuki Sakaki
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 178 (4) Pages: 55-59
- DOI
  10.1016/j.jsbmb.2017.10.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-16K14904, KAKENHI-PROJECT-16H04912
[Journal Article] Protein engineering of CYP105s for their industrial uses2018
- Author(s)
  Yasuda Kaori、Sugimoto Hiroshi、Hayashi Keiko、Takita Teisuke、Yasukawa Kiyoshi、Ohta Miho、Kamakura Masaki、Ikushiro Shinichi、Shiro Yoshitsugu、Sakaki Toshiyuki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: 1866 Pages: 23-31
- DOI
  10.1016/j.bbapap.2017.05.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221206, KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-17K15261
[Journal Article] Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator2018
- Author(s)
  Mano Hiroki、Takano Masashi、Ikushiro Shinichi、Kittaka Atsushi、Sakaki Toshiyuki
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 505 Pages: 460-465
- DOI
  10.1016/j.bbrc.2018.09.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-15K07869
[Journal Article] Elucidation of the Osteogenic Effect of Eldecalcitol in Cyp27b1-knockout Mice2018
- Author(s)
  Hirota Y, Nakagawa K, Isomoto K, Sakaki T, Kubodera N, Maya Kamao M, Osakabe N, Yoshitomo Suhara Y, Toshio Okano T.
- Journal Title
  
  PLoS ONE
  
  Volume: 13 Pages: 0199856-0199856
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04912
[Journal Article] Metabolism of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D 3 by CYP24A1 and biological activity of its 24 R -hydroxylated metabolite2018
- Author(s)
  Kaori Yasuda, Eri Tohyama, Masashi Takano, Atsushi Kittaka, Miho Ohta, Shinichi Ikushiro, and Toshiyuki Sakaki
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 178 (4) Pages: 333-339
- DOI
  10.1016/j.jsbmb.2018.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-17K15261, KAKENHI-PROJECT-16H04912
[Journal Article] Novel split luciferase-based biosensors for evaluation of vitamin D receptor ligands and their application to estimate CYP27B1 activity in living cells2018
- Author(s)
  Mano Hiroki、Ikushiro Shinichi、Sakaki Toshiyuki
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 183 Pages: 221-227
- DOI
  10.1016/j.jsbmb.2018.06.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04912
[Journal Article] Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor2017
- Author(s)
  H Mano M Nishikawa K Yasuda S Ikushiro N Saito D Sawada S Honzawa M Takano A Kittaka T Sakaki
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 167 Pages: 61-66
- DOI
  10.1016/j.jsbmb.2016.11.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-26460008, KAKENHI-PROJECT-15K18686, KAKENHI-PROJECT-16K14904, KAKENHI-PROJECT-17K15261
[Journal Article] 分割型ルシフェラーゼを用いたビタミンＤ受容体リガンド検出系の構築および化合物スクリーニングへの応用2017
- Author(s)
  真野寛生、生城真一、高野真史、橘高敦史、榊利之
- Journal Title
  
  ビタミン
  
  Volume: 91 Pages: 165-172
- NAID
  130006694371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292072
[Journal Article] Production of an active form of vitamin D 2 by genetically engineered CYP105A12017
- Author(s)
  K. Yasuda K, Y. Yogo , H.Sugimoto, H. Mano, T. Takita, M. Ohta, M. Kamakura, S. Ikushiro, K. Yasukawa, Y. Shiro, T. Sakaki.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 486 Pages: 336-341
- DOI
  10.1016/j.bbrc.2017.03.040
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221206, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-15K18686, KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-16K14904
[Journal Article] Synthesis of the CYP24A1 major metabolite of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D 32017
- Author(s)
  Takano M, Yasuda K, Tohyama E, Higuchi E, Sakaki T, Kittaka A
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: - Pages: 75-78
- DOI
  10.1016/j.jsbmb.2016.11.022
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18686, KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08031, KAKENHI-PROJECT-17K15261, KAKENHI-PROJECT-16H04912
[Journal Article] Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.2017
- Author(s)
  Y Hirota K Nakagawa S Mimatsu N Sawada T Sakaki N Kubodera M Kamao N Tsugawa Y Suhara T Okano
- Journal Title
  
  Biochem Biophys Res Commun,
  
  Volume: 483 Pages: 359-365
- DOI
  10.1016/j.bbrc.2016.12.139
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04912, KAKENHI-PROJECT-26460180, KAKENHI-PROJECT-16K08325, KAKENHI-PROJECT-16K18924, KAKENHI-PROJECT-17K00895
[Journal Article] 25-hydroxyvitamin D3 may function via genomic and non-genomic actions.2017
- Author(s)
  Y. Hirota Y. Suhara N. Osakabe T. Sakaki T. Okano
- Journal Title
  
  Anatomy &Physiology
  
  Volume: 7 Pages: 4-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04912
[Journal Article] Biosynthesis of Drug Glucuronide Metabolites in the Budding Yeast Saccharomyces cerevisiae.2016
- Author(s)
  S. Ikushiro, M. Nishikawa, Y. Masuyama, T. Shouji, M. Fujii, M. Hamada, N. Nakajima, M. Finel, K. Yasuda, M. Kamakura and T. Sakaki
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 13 Pages: 2274-2282
- DOI
  10.1021/acs.molpharmaceut.5b00954
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221206, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-15K21275
[Journal Article] Expression of UGT1A subfamily in rat brain.2016
- Author(s)
  Sakakibara Y, Katoh M, Imai K, Kondo Y, Asai Y, Ikushiro S, Nadai M.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 37 Pages: 314-319
- DOI
  10.1002/bdd.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292072
[Journal Article] Biological Evaluation of Double Point Modified Analogues of 1,25-dihydroxyvitamin D2 as Potential Anti-leukemic Agents2016
- Author(s)
  Aoife Corcoran, Sharmin Nadkarni, Kaori Yasuda, Toshiyuki Sakaki, Geoffrey Brown, Andrzej Kutner , Ewa Marcinkowska
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 17
- DOI
  10.3390/ijms17020091
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292062, KAKENHI-PROJECT-15K18686
[Journal Article] Synthesis, metabolism, and biological activity of 2-[3-(tetrazolyl)propyl]-1a,25-dihydroxy-19-norvitamin D32016
- Author(s)
  Masashi Takano, Kaori Yasuda, Erika Higuchi, Eri Tohyama, Akiko Takeuchi, Toshiyuki Sakaki, and Atsushi Kittaka
- Journal Title
  
  J Steroid Biochem Mol Biol.
  
  Volume: in press Pages: 40-44
- DOI
  10.1016/j.jsbmb.2015.07.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K18686, KAKENHI-PROJECT-16H04912
[Journal Article] Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1.2016
- Author(s)
  K. Hayashi, K. Yasuda, Y. Yogo, T. Takita, K. Yasukawa, M. Ohta, M. Kamakura, S. Ikushiro, T. Sakaki
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 473 Pages: 853-858
- DOI
  10.1016/j.bbrc.2016.03.139
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26114509, KAKENHI-PROJECT-25221206, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-15K18686
[Journal Article] Partial cloning of CYP2C23a genes and hepatic protein expression in eight representative avian species2015
- Author(s)
  Watanabe KP, Kawai YK, Nakayama SM, Ikenaka Y, Mizukawa H, Takaesu N, Ito M, Ikushiro SI, Sakaki T, Ishizuka M.
- Journal Title
  
  Journal of Veterinary Pharmacology and Therapeutics
  
  Volume: 38 Pages: 190-195
- DOI
  10.1111/jvp.12159
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-15K12213, KAKENHI-PROJECT-24248056, KAKENHI-PROJECT-15H02825, KAKENHI-PROJECT-26304043
[Journal Article] Synthesis and metabolic studies of 1α,2α,25-, 1α,4α,25- and 1α,4β,25-trihydroxyvitamin D32015
- Author(s)
  Masashi Takano, Daisuke Sawada, Kaori Yasuda, Miyu Nishikawa, Akiko Takeuchi, Ken-ichiro Takagi, Kyohei Horie, G. Satyanarayana Reddy, Tai C. Chen, Toshiyuki Sakaki, and Atsushi Kittaka
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume: 148 Pages: 34-37
- DOI
  10.1016/j.jsbmb.2014.09.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590021, KAKENHI-PROJECT-26460008
[Journal Article] Identification and In Silico Prediction of Metabolites of a Model2015
- Author(s)
  Shirotani N., Togawa M., Ikushiro S., Toshiyuki Sakaki,
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Pages: 6594-6601
- DOI
  10.1016/j.bmc.2015.09.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292072
[Journal Article] 代謝研究に基づくビタミンD作用メカニズムの再考2015
- Author(s)
  榊　利之
- Journal Title
  
  生化学
  
  Volume: 87 Pages: 1-7
- NAID
  40020571821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] Development of bioluminescent sensor to detect vitamin D receptor ligands in the living cells2015
- Author(s)
  Hiroki Mano, Miyu Nishikawa, Kaori Yasuda, Shinichi Ikushiro, Nozomi Saito, Masashi Takano, Atsushi Kittaka, and Toshiyuki Sakaki
- Journal Title
  
  Bioconjug Chem
  
  Volume: 26 Pages: 2038-2045
- DOI
  10.1021/acs.bioconjchem.5b00433
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-25292062, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-15K18686
[Journal Article] Synthesis and metabolic studies of 1α,2α,25-, 1α,4α,25- and 1α,4β,25-　trihydroxyvitamin D3.2015
- Author(s)
  Takano M, Sawada D, Yasuda K, Nishikawa M, Takeuchi A, Takagi KI, Horie K,Reddy　GS, Chen TC, Sakaki T, Kittaka A.
- Journal Title
  
  J Steroid Biochem Mol Biol.
  
  Volume: 148 Pages: 34-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] CYP24A1 as a Potential Target for Cancer Therapy2014
- Author(s)
  Toshiyuki Sakaki, Kaori Yasuda, Atsushi Kittaka, Keiko Yamamoto, and Tai C. Chen
- Journal Title
  
  Anti-Cancer Agents Med. Chem.
  
  Volume: 14 Pages: 97-108
- DOI
  10.2174/18715206113139990307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] CYP24A1 as a Potential Target for Cancer Therapy2014
- Author(s)
  T. Sakaki, K. Yasuda, A. Kittaka, K. Yamamoto, T.C. Chen
- Journal Title
  
  Anticancer Agents Med Chem
  
  Volume: 14 Pages: 97-108
- DOI
  10.1002/bab.1067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] メチルステロール酸化酵素SC4MOLによる2位置換基付加型ビタミンD誘導体の代謝2014
- Author(s)
  安田佳織、岩永由麻、小川和亮、生城真一、鎌倉昌樹、高野真史、齋藤　望、橘高敦史、藤島利江、太田美穂、榊　利之
- Journal Title
  
  ビタミン
  
  Volume: 88 Pages: 243-243
- Data Source
  KAKENHI-PROJECT-24590021
[Journal Article] Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D3 that resists the catalytic activity of both CYP27B1 and CYP24A12014
- Author(s)
  Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS.
- Journal Title
  
  J.Cell. Biochem.
  
  Volume: 115 Pages: 1392-1402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] 25-ヒドロキシビタミンDの生理機能2014
- Author(s)
  榊　利之
- Journal Title
  
  ビタミン
  
  Volume: 88 Pages: 158-160
- NAID
  110009807294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] Synthesis and Biological Activity of 1α,2α,25-Trihydroxyvitamin D3: Active Metabolite of 2α -(3-Hydroxypropoxy)-1a,25-dihydroxyvitamin D3 by Human CYP3A42014
- Author(s)
  M. Takano, S. Ohya, K. Yasuda, M. Nishikawa, A. Takeuchi, D. Sawada D, Saito H, Takenouchi K, Sakaki T, Kittaka A
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 62 Pages: 182-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls.2014
- Author(s)
  Inui, H., Itoh, T., Yamamoto, K., Ikushiro, S.-I., Sakaki, T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 15(8) Pages: 14044-14057
- DOI
  10.3390/ijms150814044
- NAID
  120005647292
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25550064, KAKENHI-PROJECT-26292072
[Journal Article] Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells,2014
- Author(s)
  E. Munetsuna, R. Kawanami, M. Nishikawa, S Ikeda, S. Nakabayashi, K Yasuda, M. Ohta, M. Kamakura, S. Ikushiro and T. Sakaki.
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 382 Pages: 960-970
- DOI
  10.1016/j.mce.2013.11.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380059, KAKENHI-PROJECT-25292062
[Journal Article] ヒト由来CYP2R1発現酵母を用いた25-ヒドロキシビタミンD2の生産2014
- Author(s)
  安田佳織、遠藤真理子、小又早紀、生城真一、鎌倉昌樹、太田美穂、榊利之
- Journal Title
  
  ビタミン
  
  Volume: 88 Pages: 451-457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] Synthesis and Biological Activity of 1α,2α,25-Trihydroxyvitamin D<sub>3</sub>: Active Metabolite of 2α-(3-Hydroxypropoxy)-1α,25-dihydroxyvitamin D<sub>3</sub> by Human CYP3A42014
- Author(s)
  Masashi Takano, Saori Ohya, Kaori Yasuda, Miyu Nishikawa, Akiko Takeuchi, Daisuke Sawada, Toshiyuki Sakaki, and Atsushi Kittaka
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 62 (2) Issue: 2 Pages: 182-184
- DOI
  10.1248/cpb.c13-00646
- NAID
  130003390755
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590015, KAKENHI-PROJECT-24590021, KAKENHI-PROJECT-25860011, KAKENHI-PROJECT-26460008
[Journal Article] Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver.2013
- Author(s)
  Kensuke P WATANABE, et al.
- Journal Title
  
  PLOS ONE
  
  Volume: 8(9)
- DOI
  10.1371/journal.pone.0075689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J01864, KAKENHI-PROJECT-23580179, KAKENHI-PROJECT-24248056
[Journal Article] ビタミンDとシトクロムP450の遺伝子多型2013
- Author(s)
  榊　利之、西川美宇
- Journal Title
  
  ビタミン
  
  Volume: 87 Pages: 519-524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] 1,25-(OH)2D-24-hydroxylase (CYP24A1) deficiency as a cause of nephrolithiasis2013
- Author(s)
  G. Nesterova, M. Christine, K. Yasuda, T. Sakaki, T. Vilboux, C. Ciccone, R. Horst, Y Huang, G. Golas, W. Introne, M. Huizing, D. Adams, C.F. Boerkoel, M.T.Collins, W.A. Gahl
- Journal Title
  
  Clinical Journal of the American Society of Nephrology
  
  Volume: 8 Pages: 649-657
- DOI
  10.2215/cjn.05360512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292062
[Journal Article] UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R12013
- Author(s)
  Yasuda K, et al.
- Journal Title
  
  Biochemistry and Biophysics of Research Communication
  
  Volume: 434 Pages: 311-315
- DOI
  10.1016/j.bbrc.2013.02.124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380059, KAKENHI-PROJECT-25292062
[Journal Article] Comparison of Serotonin Glucuronidation Activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: Evidence for the Preferential Expression of Ugt1a6a in the Mouse Brain2013
- Author(s)
  Uchihashi S, Nishikawa　M., Sakaki　T., and Ikushiro S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 28 Pages: 260-264
- NAID
  130004463298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R12013
- Author(s)
  Yasuda K, Endo M, Ikushiro S,Kamakura M, Ohta M, Sakaki T.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 434 Pages: 311-315
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] Human Cytochrome P450-Dependent Differential Metabolism Among Three 2α-Substituted-1α,25-dihydroxyvitamin D3 Analogs2013
- Author(s)
  Yasuda, K, Ikushiro, S, Sakaki, T
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume: 133 Pages: 84-92
- DOI
  10.1016/j.jsbmb.2012.09.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510229, KAKENHI-PROJECT-24590021
[Journal Article] Comparison of Serotonin Glucuronidation Activity of UDP- glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b : Evidence for the Preferential Expression of Ugt1a6a in the Mouse2013
- Author(s)
  Uchihashi S, Nishikawa M., Sakaki T., and Ikushiro S.
- Journal Title
  
  Brain Drug Metab Pharmacokinet
  
  Volume: 28 Pages: 260-264
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] The roles of cytochrome P450 enzymes in prostate cancer development and treatment2012
- Author(s)
  Chen TC, Sakaki T, Yamamoto K, Kittaka A
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Pages: 291-298
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] The roles of cytochrome p450 enzymes in prostate cancer development and treatment2012
- Author(s)
  Chen TC, Sakaki T, Yamamoto K, Kittaka A
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Pages: 291-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation.2012
- Author(s)
  Uchihashi S, Nishikawa　M., Sakaki　T., and Ikushiro S.
- Journal Title
  
  J.Biochem.
  
  Volume: 152 Pages: 331-340
- NAID
  10031166146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] The critical role of amino acid residue at position 117 of mouse UDP- glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation2012
- Author(s)
  Uchihashi S, Nishikawa M., Sakaki T., and Ikushiro S.
- Journal Title
  
  J.Biochem
  
  Volume: 152 Pages: 331-340
- NAID
  10031166146
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D(3) analogs.2012
- Author(s)
  Yasuda K, Ikushiro S, Kamakura M, Takano M, Saito N, Kittaka A, Chen TC, Ohta M, Sakaki T.
- Journal Title
  
  J Steroid Biochem Mol Biol
  
  Volume: 133 Pages: 84-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] Mechanism of the Anti-proliferative Action of 25-Hydroxy-19-nor-vitamin D3 in Human Prostate CellsVD_3 action2011
- Author(s)
  Munetsuna E., Kittaka A, Sakaki T.(他8名)
- Journal Title
  
  J Mol Endocrinol
  
  Volume: 47 Pages: 209-218
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D_3 with 3-hydroxypropyl group generates an analog with enhanced chemotherapeutic potency in PC-3 prostate cancer cells2011
- Author(s)
  Iglesias-Gato D, Kittaka A, Sakaki T, 他8名
- Journal Title
  
  J.Steroid.Mol.Biol.
  
  Volume: 127 Pages: 269-275
- DOI
  10.1016/j.bbadis.2010.07.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Sequential metabolism of sesamine by cytochrome P450 and UGT-glucuronosyltransferase in human liver.2011
- Author(s)
  Yasuda K, Ikushiro S, Kamakura M, Munetsuna E, Ohta M, Sakaki T.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39 Pages: 1538-1545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] Multiple isoform dependent glucuronidation of a selective c-Fos/activator protein-1 inhibitor T-5224.2011
- Author(s)
  Uchihashi, S.,Fukumoto, H., Onoda, M., Hayakawa, H., Ikushiro, S., and Sakaki, T.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39 Pages: 803-813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] Sequential metabolism of sesamine by cytochrome P450 and UGT-glucuronosyltransferase in human liver2011
- Author(s)
  Yasuda K, Ikushiro S, Kamakura M, Munetsuna E, Ohta M, Sakaki T.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39 Pages: 1538-1545
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P4502011
- Author(s)
  Sakaki T, Sugimoto H, Hayashi K, Ikushiro S, (他4名)
- Journal Title
  
  Biochem.Biophys.Acta
  
  Volume: 1814 Pages: 249-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659043
[Journal Article] Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P4502011
- Author(s)
  Sakaki T, Sugimoto H, Hayashi K, Ikushiro S(他4名)
- Journal Title
  
  Biochem. Biophys. Acta
  
  Volume: 1814 Pages: 249-256
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3`,4,4`2011
- Author(s)
  Yamazaki K, Sakaki T
- Journal Title
  
  5-pentachlorobiphenyl,Journal of Biochemistry
  
  Volume: 149 Pages: 487-494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510229
[Journal Article] Metabolism of the c-Fos/Activator Protein-1 Inhibitor T-5224 by Multiple Human UDP-Glucuronosyltransferase Isoforms2011
- Author(s)
  Uchihashi, S.,Ikushiro, S.,Sakaki, T.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39 Pages: 803-813
- DOI
  10.1124/dmd.110.037952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510229
[Journal Article] Substitution at carbon 2 of 19-nor-1a, 25-dihydroxyvitamin D_3 with 3-hydroxypropyl group generates an analog with enhanced chemotherapeutic potency in PC-3 prostate cancer cells2011
- Author(s)
  Iglesias-Gato D, Zheng S, Flanagan J. N., Jiang L, Kittaka A, Sakaki T, (他5名)
- Journal Title
  
  J. Steroid. Mol. Biol
  
  Volume: 127 Pages: 269-275
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3',4,4',5-pentachlorobiphenyl2011
- Author(s)
  Yaraazaki K, Sakaki T, 他8名
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 149 Pages: 487-494
- DOI
  10.1093/jb/mvr009
- NAID
  10030584940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510229, KAKENHI-PROJECT-23241028
[Journal Article] Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P4502011
- Author(s)
  Sakaki T, Sugimoto H, Hayashi K, Ikushiro S, 他4名
- Journal Title
  
  Biochem.Biophys.Acta
  
  Volume: 1814 Pages: 249-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Multiple isoform dependent glucuronidation of a selective c-Fos/activator protein-1 inhibitor T-52242011
- Author(s)
  Uchihashi, S.,Fukumoto, H., Onoda, M., Hayakawa, H., Ikushiro, S., and Sakaki, T.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39 Pages: 803-813
- Data Source
  KAKENHI-PROJECT-23580179
[Journal Article] CYP 105A1二重変異体を発現する放線菌を用いた活性型ビタミンD_3の生産2010
- Author(s)
  安田佳織、杉本宏、橘高敦史, 榊利之, 他6名
- Journal Title
  
  ビタミン誌
  
  Volume: 82 Pages: 649-661
- NAID
  110008607853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Studies on Synthesis and Metabolism of 14-epi-2a-(3-Hydroxy propyl)-19-norvitamin D_3 and its 2a-isomer2010
- Author(s)
  Kittaka A, Hara H, Yasuda K, Sakaki T(他6名)
- Journal Title
  
  Heterocycles
  
  Volume: 82 Pages: 649-661
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Metabolism of sesamin by cytochromes P450 in human liver microsomes2010
- Author(s)
  Yasuda K, Ikushiro S, Kamakura M, Ohta M, and Sakaki T
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 38 Pages: 2117-2123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510229
[Journal Article] Three-step hydroxylation of vitamin D_3 by a genetically engineered CYP105A12010
- Author(s)
  Hayashi K, Sugimoto H, Kittaka A, Sakaki T(他6名)
- Journal Title
  
  FEBS J
  
  Volume: 277 Pages: 3999-4009
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Studies on Synthesis and Metabolism of 14-epi-2a-(3-Hydroxypropyl) -19-norvitamin D_3 and its 2a-isomer2010
- Author(s)
  Kittaka A, Hara H, Yasuda K, Sakaki T, 他6名
- Journal Title
  
  Heterocycles
  
  Volume: 82 Pages: 649-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Metabolism of sesamin by cytochromes P450 in human liver microsomes2010
- Author(s)
  Yasuda, K., Ikushiro, S., Kamakura, M., Ohta, M., Sakaki, T.
- Journal Title
  
  Drug Metabolism and Disposition 382010
  
  Pages: 2117-2123
- Data Source
  KAKENHI-PROJECT-20580138
[Journal Article] Three-step hydroxylation of vitamin D_3 by a genetically engineered CYP 105A12010
- Author(s)
  Hayashi K, Sugimoto H, Kittaka A, Sakaki T, 他6名
- Journal Title
  
  FEBS J
  
  Volume: 277 Pages: 3999-4009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] CYP105A1二重変異体を発現する放線菌を用いた活性型ビタミンD_3の生産2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之(他6名)
- Journal Title
  
  ビタミン誌
  
  Volume: 82 Pages: 649-661
- NAID
  110008607853
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] 14-epi-MART-10 and 14-epi-MART-11 with Antiproliferative and Cell Differentiation : Synthesis and Biological Evaluations2009
- Author(s)
  Kittaka A, Hara H, Takano M, Sakaki T, 他13名
- Journal Title
  
  Anticancer Res. 29
  
  Pages: 3563-3569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 2α-Propoxy-1α, 25-dihydroxyvitamin D_3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A12009
- Author(s)
  Saito N, Suhara Y, Sakaki T, Kittaka A, 他3名
- Journal Title
  
  Bioorganic & Medicinal Chemistry 17
  
  Pages: 4296-4301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Evaluation of 19-nor-2a-(3-hydroxyl propyl)-1a, 25-dihydroxyvitamin D_3 As a Therapeutic Agent for Androgendependent Prostate Cance2009
- Author(s)
  Flanagan JN, Zheng S, Kittaka A, Sakaki T, (他10名)
- Journal Title
  
  Anticancer Res
  
  Volume: 29 Pages: 3547-3553
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Quantitative analysis of UGT1A and UGT2B expression levels in human livers2009
- Author(s)
  Izukawa, T., Nakajima, M., Fujiwara, R., Yamanaka, H., Fukami, T., Takamiya, M., Aoki, Y., Ikushiro, S., Sakaki, T., Yokoi, T.
- Journal Title
  
  Drug Metabolism and Disposition 37
  
  Pages: 1759-1768
- Data Source
  KAKENHI-PROJECT-20580138
[Journal Article] Metabolism of 1α, 25-dihydroxyvitamin D_2 by human CYP24A12009
- Author(s)
  Urushino N, Yasuda K, Ikushiro S, Kamakura M, Ohta M, Sakaki T
- Journal Title
  
  Biochem.Biophys.Res.Commun. 384
  
  Pages: 144-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Evaluation of 19-nor-2α-(3-hydroxypropyl)-1α, 25-dihydroxyvitamin D_3 As a Therapeutic Agent for Androgen-dependent Prostate Cancer2009
- Author(s)
  Flanagan JN, Zheng S, Kittaka A, Sakaki T, 他10名
- Journal Title
  
  Anticancer Res. 29
  
  Pages: 3547-3553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D_3 catabolism in macrophages2009
- Author(s)
  Matsunawa M, Amano Y, Endo K, Sakaki T, 他3名
- Journal Title
  
  Toxicological Sciences 109
  
  Pages: 50-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Metabolism of 1α, 25-dihydroxyvitamin D_2 by human CYP24A12009
- Author(s)
  Hashimoto M, Higuchi Y, Sakaki T, Dairi T., 他5名
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 19
  
  Pages: 5640-5643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] The aryl hydrocarbon receptor activator benzo[a] pyrene enhances vitamin D_3 catabolism in macrophages2009
- Author(s)
  Matsunawa M, Amano Y, Endo K, Sakaki T, (他3名)
- Journal Title
  
  Toxicological Sciences
  
  Volume: 109 Pages: 50-58
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 2a-Propoxy-1α, 25-dihydroxyvitamin D_3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A12009
- Author(s)
  Saito N, Suhara Y, Sakaki T, Kittaka A(他3名)
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 19 Pages: 5640-5643
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] 14-epi-MART-10 and 14-epi-MART-11 with Antiproliferative and Cell Differentiation2009
- Author(s)
  Kittaka A, Hara H, Takano M, Sakaki T(他13名)
- Journal Title
  
  Anticancer Res
  
  Volume: 29 Pages: 3563-3569
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D_3 catabolism in macrophages2009
- Author(s)
  Matsunawa, M., Sakaki T., Makishima M., et al
- Journal Title
  
  Toxicological Sciences (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659032
[Journal Article] Metabolism of 1E, 25-dihydroxyvitamin D_2 by human CYP24A12009
- Author(s)
  Urushino N, Yasuda K, Ikushiro S, Kamakura M, Ohta M, Sakaki T
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 384 Pages: 144-148
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Synthesis of 25-hydroxy-19-norvitamin D_3 analo2006
- Author(s)
  Arai, M.A., Tsutsumi, R., Chen, T.C., Sakaki, T., Urushino, N., 他
- Journal Title
  
  Heterocycles 66
  
  Pages: 469-479
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Synthesis of 25-hydroxy-19-norvitamin D_3 analogs and their antiproliferative activities on prostate cells2006
- Author(s)
  Arai, M.A., Tsutsumi, R., Chen, T.C., Sakaki, T., Urushino, N., Inouye, K., Kittaka, A.
- Journal Title
  
  Heterocycles 66
  
  Pages: 469-479
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Interaction between Mitochondrial CYP27B1 and Adrenodoxin : Role of Arginine 458 of Mouse CYP27B12006
- Author(s)
  Urushino, N., Yamamoto, K., Kagawa, N., Ikushiro, S., Sakaki, T.他
- Journal Title
  
  Biochemistry 45
  
  Pages: 4405-4412
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1α,25-dihydroxyvitamin D3: Implications for drug-induced osteomalacia.2006
- Author(s)
  Xu, Y., Hashizume, T., Shuhart, M., Davis, C.L., Nelson, W.L., Sakaki, T., Kalhorn, T.F., Watkins, P.B., Schuetz, E.G.
- Journal Title
  
  Mol.Pharmacol. 69
  
  Pages: 56-65
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1α,25-dihydroxyvitamin D_3 : Implications for drug-induced osteomalacia.2006
- Author(s)
  Xu, Y., Hashizume, T., Shuhart, M., Davis, C.L., Nelson, W.Sakaki, T.他
- Journal Title
  
  Molecular Pharmacology 69
  
  Pages: 56-65
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis : amino acid resides responsible for species-based difference of CYP24A1 between humans and rats.2006
- Author(s)
  Hamamoto, H., Kusudo, T., Urushino, N., Masuno, H., Sakaki, T.他
- Journal Title
  
  Molecular Pharmacology (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Interaction between Mitochondrial CYP27B1 and Adrenodoxin : Role of Arginine 458 of Mouse CYP27B1.2006
- Author(s)
  Urushino, N., Yamamoto, K., Kagawa, N., Ikushiro, S., Kamakura, M., Yamada, S., Kato, S., Inouye, K., Sakaki, T.
- Journal Title
  
  Biochemistry 45
  
  Pages: 4405-4412
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Structure-function analysis of vitamin D24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid resides responsible for species-based difference of CYP24A1 between humans and rats.2006
- Author(s)
  Hamamoto, H., Kusudo, T., Urushino, N., Masuno, H., Yamamoto, K., Yamada, S., Kamakura, M., Ohta, M., Inouye, K., Sakaki, T.
- Journal Title
  
  Mol.Pharmacol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Synthesis of 25-hydroxy-19-norvitamin D_3 analogs and their antiproliferative activities on prostate cells2006
- Author(s)
  Arai, M.A., Tsutsumi, R., Chen, T.C., Sakaki, T., Urushino, N., Inouye, K.他
- Journal Title
  
  Heterocycles 66
  
  Pages: 469-479
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1α,25-dihydroxyvitamin D_3 : Implications for drug-induced osteomalacia.2006
- Author(s)
  Xu, Y., Hashizume, T., Shuhart, M., Davis, C.L., Sakaki, T.他
- Journal Title
  
  Molecular Pharmacology 69
  
  Pages: 56-65
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Measurement and characterization of C-3 epimerization activity toward vitamin D_3.2005
- Author(s)
  Kamao, M., Hatakeyama, S., Sakaki, T., Sawada, N., Inouye, K., Kubodera, N., Reddy, S., Okano, T.
- Journal Title
  
  Arch.Biochem.Biophys. 436
  
  Pages: 196-205
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of 2α-propoxy-1α,25-dihydroxyvitamin D_3 and 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A12005
- Author(s)
  Abe, D., Sakaki, T., Kusudo, T., Kittaka, A., Saito, N., Suhara, Y., Fujishima, T., Takayama, H., Hamamoto, H., Kamakura, M., Ohta, M., Inouye, K.
- Journal Title
  
  Drug Metab.Disp. 33
  
  Pages: 778-784
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] 2α-propoxy-1α,25-dihydroxyvitamin D_3 and 2α(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D_3 by human CYP27A1 and CYP24A12005
- Author(s)
  Abe, D., Sakaki, T., Kusudo, T., Kittaka, A., Saito, N., Suhara, Y., Fujishima, T., 他
- Journal Title
  
  Drug Metabolism and Disposition 33
  
  Pages: 778-784
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Identification of the amino acid residue of CYP27B1 responsible for binding of 25hydroxyvitamin D_3 whose mutation causes vitamin D-dependent rickets type 1.2005
- Author(s)
  Yamamoto, K, Uchida, E., Urushino, N., Sakaki, T., Kagawa, N., Sawada, N 他
- Journal Title
  
  Journal of Biological Chemistry 280
  
  Pages: 30511-30516
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of 26,26,26,27,27,27-F_G-1α,23S,25-trihydroxy vitamin D_3 by human UDP-glucuronosyltransferase 1A32005
- Author(s)
  Kasai, N., Sakaki, T., Shinkyo, R., Ikushiro, S., Iyanagi, T., Ohta, M.他
- Journal Title
  
  Drug Metabolism and Disposition 33
  
  Pages: 102-107
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of vitamin D_3 by cytochromes P450.2005
- Author(s)
  Sakaki, T., Kagawa, N., Yamamoto, K., Inouye, K.
- Journal Title
  
  Frontiesr in Bioscience 10
  
  Pages: 119-134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Identification of the amino acid residue of CYP27B1 responsible for binding of 25hydroxyvitamin D_3 whose mutation causes vitamin D-dependent rickets type 1.2005
- Author(s)
  Yamamoto, K., Uchida, E., Urushino, N., Sakaki, T., Kagawa, N.Sawada, N 他
- Journal Title
  
  Journal of Biological Chemistry 280
  
  Pages: 30511-30516
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D_3 whose mutation causes vitamin D-dependent rickets type 1.2005
- Author(s)
  Yamamoto, K., Uchida, E., Urushino, N., Sakaki, T., Kagawa, N., Sawada, N., Kamakura, M., Kato, S., Inouye, K., Yamada, S.
- Journal Title
  
  J Biol.Chem. 280
  
  Pages: 30511-30516
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of 26,26,26,27,27,27-F_6- 1α, 23S, 25-trihydroxyvitamin D_3 by human UDP-glucuronosyltransferase 1A3.2005
- Author(s)
  Kasai, N., Sakaki, T., Shinkyo, R., Ikushiro, S., Iyanagi, T., Ohta, M., Inouye, K.
- Journal Title
  
  Drug Metab.Disp. 33
  
  Pages: 102-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of 26,26,26,27,27,27-F_6-1α,23S,25-trihydroxyvitamin D_3 by human UDP-glucuronosyltransferase 1A32005
- Author(s)
  Kasai, N., Sakaki, T., Shinkyo, R., Ikushiro, S., Iyanagi, T., Ohta, M.他
- Journal Title
  
  Drug Metabolism and Disposition 33
  
  Pages: 102-107
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] 2α-propoxy-1α,25-dihydroxyvitamin D_3 and 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D_3 by human CYP27A1 and CYP24A12005
- Author(s)
  Abe, D., Sakaki, T., Kusudo, T., Kittaka, A., Saito, N., Suhara, Y,.Fujishima, T., 他
- Journal Title
  
  Drug Metabolism and Disposition 33
  
  Pages: 778-784
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Homology modeling of human 25-hydroxyvitamin D_3 1α-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C5.2004
- Author(s)
  Yamamoto K., Masuno H., Sawada N., Sakaki T.他
- Journal Title
  
  Journal of Steroid Biochemistry and Molecular Biology 89-90
  
  Pages: 167-171
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] C-3 Epimerization of vitamin D_3 metabolites and further metabolism of C-3 epimers : 25-Hydroxyvitamin D_3 is metabolized to 3-epi-25-hydroxyvitamin D_3 and subsequently2004
- Author(s)
  Kamao M., Tatematsu S., Hatakeyana S., Sakaki T., Okano T.他
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 15897-15907
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES.2004
- Author(s)
  Uchida, E., Kagawa, N., Sakaki, T., Urushino, N., Sawada, N., Kamakura, M., Ohta, M., Kato, S., Inouye, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 323
  
  Pages: 505-511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Conversion of vitamin D_3 to 1α,25-dihydroxyvitamin D_3 by Streptomyces griseolus cytochrome P450SU-1 (CYP105A1)2004
- Author(s)
  Sawada, N., Sakaki.T., Yoneda, S., Kusudo, T., Shinkyo, R., Ohta, M., Inouye, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 320
  
  Pages: 156-164
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Conversion of vitamin D_3 to 1a,25-dihydroxyvitamin D_3 by Streptomyces griseolus cytochrome P450SU-1(CYP105A1)2004
- Author(s)
  Sawada N., Sakaki T., Yoneda S Kusudo T., Shinkyo R., Ohta M.他
- Journal Title
  
  Biochemical and Biophysical Research Communications 320
  
  Pages: 156-164
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of vitamin D by human microsomal CYP2R1.2004
- Author(s)
  Shinkyo R., Sakaki T., Kamakura M., Ohta M, Inouye K.
- Journal Title
  
  Biochemical and Biophysical Research Comunications 324
  
  Pages: 451-457
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Novel metabolism of 1α,25-dihydroxyvitamin D_3 with C_<24>-C_<25> bond cleavage catalyzed by human CYP24A12004
- Author(s)
  Sawada N., Kusudo T., Sakaki T., Hatakeyama S., Okano T.他
- Journal Title
  
  Biochemistry 43
  
  Pages: 4530-4537
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D_3 by CYP24A12004
- Author(s)
  Kusudo T., Sakaki T., Abe D., Fujishima T., Kittaka A., Takayama H.他
- Journal Title
  
  Biochemical and Biophysical Research Comunications 321
  
  Pages: 774-782
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of vitamin D by human microsomal CYP2R12004
- Author(s)
  Shinkyo R., Sakaki T., Kamakura M., Ohta M.Inouye K.
- Journal Title
  
  Biochemical and Biophysical Research Communications 324
  
  Pages: 451-457
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Novel metabolism of 1α,25-dihydroxyvitamin D_3 with C_<24>- C_<25> bond cleavage catalyzed by human CYP24A12004
- Author(s)
  Sawada N., Kusudo T., Sakaki T., Hatakeyama S., Okano T.他
- Journal Title
  
  Biochemistry 43
  
  Pages: 4530-4537
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D_3 by CYP24A1.2004
- Author(s)
  Kusudo, T., Sakaki, T., Abe, D., Fujishima, T., Kittaka, A., Takayama, H., Hatakeyama, S., Ohta, M., Inouye, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 321
  
  Pages: 774-782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] C-3 Epimerization of vitamin D_3 metabolites and further metabolism of C-3 epimers : 25-Hyfroxyvitamin D_3 is metabolized to 3-epi-25hydroxyvitamin D_32004
- Author(s)
  Kamao M., Tatematsu S., Hatakeyama S., Sakaki, T., Okano T.他
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 15897-15907
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Homology modeling of human 25-hydroxyvitamin D_31α-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C52004
- Author(s)
  Yamamoto K., Masuno H., Sawada N., Sakaki T.他
- Journal Title
  
  Journal of Steroid Biochemistry and Molecular Biology 89-90
  
  Pages: 167-171
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D_3 by CYP24A12004
- Author(s)
  Kusudo T., Sakaki T., Abe D., Fujishima T., Kittaka A.他
- Journal Title
  
  Biochemical and Biophysical Research Communications 321
  
  Pages: 774-782
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Conversion of vitamin D_3 to 1α,25-dihydroxyvitamin D_3 by Streptomyces griseolus cytochrome P450SU-1 (CYP105A1)2004
- Author(s)
  Sawada N., Sakaki T., Yoneda S., Kusudo T., Shinkyo R., Ohta M.他
- Journal Title
  
  Biochemical and Biophysical Research Comunications 320
  
  Pages: 156-164
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES2004
- Author(s)
  Uchida E., Kagawa N., Sakaki T., Urushino N., Sawada N.他
- Journal Title
  
  Biochemical and Biophysical Research Communications 323
  
  Pages: 505-511
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Metabolism of vitamin D by human microsomal CYP2R1.2004
- Author(s)
  Shinkyo, R., Sakaki, T., Kamakura, M., Ohta, M., Inouye, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 324
  
  Pages: 451-457
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES.2004
- Author(s)
  Uchida E., Kagawa N., Sakaki T., Urushino N., Sawada N.他
- Journal Title
  
  Biochemical and Biophysical Research Comunications 323
  
  Pages: 505-511
- Data Source
  KAKENHI-PROJECT-16580074
[Journal Article] Enzymatic properties of human CYP2W1 expressed in Escherichia coli.
- Author(s)
  Yoshioka, H., Kasai, N., Ikushiro, S., Shinkyo, R., Kamakura, M., Ohta, M., Inouye, K., Sakaki, T.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 345
  
  Pages: 169-174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580074
[Patent] 分割型ルシフェラーゼ及びそれを用いたビタミンD受容体リガンドの高感度検出法2017
- Inventor(s)
  榊　利之、真野寛生、西川美宇
- Industrial Property Rights Holder
  富山県立大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-210604
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K14904
[Patent] 変異型ビタミン受容体遺伝子を有する２型くる病モデル動物及びその製造方法2017
- Inventor(s)
  榊　利之、真野寛生、西川美宇、生城真一
- Industrial Property Rights Holder
  富山県立大学、ファンケル
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-040836
- Filing Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16H04912
[Patent] 1α,25-ジヒドロキシビタミンD2の製造方法2014
- Inventor(s)
  榊　利之、生城真一、戸田佳織
- Industrial Property Rights Holder
  榊　利之、生城真一、戸田佳織
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-193073
- Filing Date
  2014-09-22
- Data Source
  KAKENHI-PROJECT-25292062
[Patent] 出芽酵母形質転換体2013
- Inventor(s)
  生城真一、榊利之、安田佳織
- Industrial Property Rights Holder
  富山県
- Industrial Property Rights Type
  特許
- Acquisition Date
  2013-03-13
- Overseas
- Data Source
  KAKENHI-PROJECT-23580179
[Patent] 25ヒドロキシビタミンD2の製造方法2012
- Inventor(s)
  榊利之、生城真一、安田佳織
- Industrial Property Rights Holder
  富山県
- Filing Date
  2012-02-15
- Data Source
  KAKENHI-PROJECT-21380067
[Patent] 出芽酵母形質転換体2012
- Inventor(s)
  生城真一、榊利之、安田佳織
- Industrial Property Rights Holder
  富山県
- Industrial Property Rights Type
  特許
- Filing Date
  2012-07-12
- Acquisition Date
  2013-03-01
- Data Source
  KAKENHI-PROJECT-23580179
[Patent] 出芽酵母を用いたグルクロン酸抱合体の製造方法2011
- Inventor(s)
  生城真一、榊利之、安田佳織
- Industrial Property Rights Holder
  富山県
- Filing Date
  2011-02-14
- Overseas
- Data Source
  KAKENHI-PROJECT-20580138
[Patent] 出芽酵母を用いたグルクロン酸抱合体の製造方法2011
- Inventor(s)
  生城真一, 榊利之, 安田佳織
- Industrial Property Rights Holder
  富山県
- Filing Date
  2011-02-14
- Overseas
- Data Source
  KAKENHI-PROJECT-20580138
[Patent] 遺伝子改変酵母を用いた硫酸抱合体の製造方法2011
- Inventor(s)
  生城真一、榊利之
- Industrial Property Rights Holder
  富山県
- Industrial Property Number
  2011-028515
- Filing Date
  2011-02-14
- Data Source
  KAKENHI-PROJECT-20580138
[Patent] 遺伝子改変酵母を用いた硫酸抱合体の製造方法2011
- Inventor(s)
  生城真一, 榊利之
- Industrial Property Rights Holder
  富山県
- Industrial Property Number
  2011-028515
- Filing Date
  2011-02-14
- Data Source
  KAKENHI-PROJECT-20580138
[Patent] 出芽酵母を用いたグルクロン酸抱合体の製造方法2010
- Inventor(s)
  生城真一, 榊利之, 安田佳織
- Industrial Property Rights Holder
  富山県
- Industrial Property Number
  2010-040150
- Filing Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-20580138
[Patent] 出芽酵母を用いたグルクロン酸抱合体の製造方法2010
- Inventor(s)
  生城真一、榊利之、安田佳織
- Industrial Property Rights Holder
  富山県
- Industrial Property Number
  2010-040150
- Filing Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-20580138
[Patent] グルクロン酸転移酵素の製造方法2009
- Inventor(s)
  生城真一、榊利之、安田佳織
- Industrial Property Rights Holder
  富山県
- Industrial Property Number
  2009-222731
- Filing Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-20580138
[Patent] 1a, 25, 26-トリヒドロキシビタミンDの製造方法2009
- Inventor(s)
  榊利之、生城真一、安田佳織
- Industrial Property Rights Holder
  富山県
- Filing Date
  2009-06-17
- Data Source
  KAKENHI-PROJECT-21380067
[Patent] グルクロン酸転移酵素の製造方法2009
- Inventor(s)
  生城真一, 榊利之, 安田佳織
- Industrial Property Rights Holder
  富山県
- Industrial Property Number
  2009-222731
- Filing Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-20580138
[Patent] 1α, 25, 26-トリヒドロキシビタミンDの製造方法2009
- Inventor(s)
  榊利之, 生城真一, 安田佳織
- Industrial Property Rights Holder
  富山県
- Industrial Property Number
  2009-014432
- Filing Date
  2009-06-17
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 生体内におけるCYP24A1およびCYP3A依存性ビタミンD代謝解析2020
- Author(s)
  本谷小佑里・川越文裕安田佳織・上杉志成榊　利之・橘高敦史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] 2-[2-(テトラゾール-2-イル)エチル]活性型ビタミンD3の19-ノル体合成と代謝2019
- Author(s)
  安田佳織・西川美宇岡本海利・高松将士阿部圭祐・真野寛生中川公恵・津川尚子岡野登志夫・生城真一榊利之
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 生体内におけるCYP24A1およびCYP3A4依存的ビタミンD代謝解析2019
- Author(s)
  安田佳織・岡本海利西川美宇・真野寛生川越文裕・中川公恵津川尚子・岡野登志夫橘高敦史・生城真一榊利之
- Organizer
  日本ビタミン学会第71回大会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] Effects of vitamin D on development of bone osteogenesis and skeletal muscle in Cyp27b1-KO and Vdr-KO rickets rat models2019
- Author(s)
  K. Hibi M. Nishikawa S. Ikushiro T. Sakaki
- Organizer
  ICoFF2019　7th International conference on food factors
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] くる病患者由来の変異型VDR（R274L）に対して親和性の高い化合物の新規探索方法の開発2019
- Author(s)
  真野寛生・生城真一高野真史・橘高敦史榊利之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] SYNTHESIS OF 2-(2-TRIAZOLYLETHYL)-1a,25-DIHYDROXY-19-NORVITAMIN D3 AND ITS METABOLISM2019
- Author(s)
  M. Takano K. Yasuda H. Mano T. Sakaki A. Kittaka
- Organizer
  The 22nd Vitamin D workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] Comparative study of 25-hydroxyvitamin D3 treatment between Cyp27b1 knockout and Vdr (R270L) rats to evaluate clinical effects of 25(OH)D3.2019
- Author(s)
  M. Nishikawa K. Abe K. Yasuda H. Mano S. Ikushiro T. Sakaki
- Organizer
  21th International Conference on Cytochrome P450
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] Elucidation of molecular mechanism of vitamin D actions using genetically modified rats in CYP27B1 or vitamin D receptor2019
- Author(s)
  T. Sakaki
- Organizer
  ICoFF2019　7th International conference on food factors
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] VDRリガンドに応答して発光量が劇的に上昇する分割型ルシフェラーゼバイオセンサーの開発2019
- Author(s)
  真野寛生・生城真一高野真史・橘高敦史榊利之
- Organizer
  日本ビタミン学会第71回大会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] 変異型VDR導入ラットを用いた25(OH)ビタミンD3およびビタミンD誘導体の骨形成作用評価2019
- Author(s)
  西川美宇・阿部圭祐安田佳織・真野寛生高野真史・橘高敦史生城真一・榊利之
- Organizer
  日本ビタミン学会第71回大会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] Clinical importance of 25-hydroxyvitamin D3 for rickets. Comparative study of 25(OH)D3 treatment to Cyp27b1 knockout or Vdr (R270L) rats.2019
- Author(s)
  M. Nishikawa K. Abe K. Yasuda H. Mano S. Ikushiro T. Sakaki
- Organizer
  The 22nd Vitamin D workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] ELUCIDATION of 25-HYDROXYVITAMIN D3 METABOLISM USING Cyp24a1-KNOCKOUT RATS GENERATED by CRISPR/Cas9 SYSTEM2019
- Author(s)
  K. Yasuda K. Okamoto M. Nishikawa F. Kawagoe K. Nakagawa N. Tsugawa T. Okano A. Kittaka S. Ikushiro T. Sakaki
- Organizer
  The 22nd Vitamin D workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] CYP24A1代謝抵抗性をもつビタミンD3誘導体合成2019
- Author(s)
  本谷小佑里・川越文裕安田佳織・上杉志成榊　利之・橘高敦史
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] ゲノム編集法により作出したCYP27B1 遺伝子欠損および VDR 遺伝子改変ラットを用いたビタミンD作用メカニズムの解明2019
- Author(s)
  西川美宇, 安田佳織, 高松将士, 阿部圭祐, 堀部恭平, 真野寛生, 中川公恵, 津川尚子, 岡野登志夫, 生城真一, 榊利之
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP24A1遺伝子欠損ラットへの25-ヒドロキシビタミンD3代謝様式解明.2019
- Author(s)
  安田佳織,・西川美宇　岡本海利・中川公恵津川尚子・岡野登志夫,生城真一・榊利之.
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] Molecular mechanism of vitamin D action in the rats getetically deficient in CYP27B1 or vitamin D receptor2019
- Author(s)
  T. Sakaki
- Organizer
  21th International Conference on Cytochrome P450
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] 各種遺伝子改変ラットに対する25-ヒドロキシビタミンD3の投与効果および代謝解析2019
- Author(s)
  安田佳織・西川美宇真野寛生・川越文裕中川公恵・津川尚子岡野登志夫・橘高敦史生城真一・榊利之
- Organizer
  第364回脂溶性ビタミン委員会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] ビタミンD代謝酵素の構造と機能に関する研究2019
- Author(s)
  榊　利之
- Organizer
  日本ビタミン学会第71回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] Introduction of fluorine atoms on VITAMINE D3 SIDE-CHAIN AT C24 POSITION2019
- Author(s)
  F. Kawagoe S. Mototani K. Yasuda K. Nagasawa M. Uesugi T. Sakaki A. Kittaka
- Organizer
  The 22nd Vitamin D workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] 側鎖24位がジフルオロ化されたビタミンD3CD環部の合成2019
- Author(s)
  川越文裕・本谷小佑里安田佳織・上杉志成榊　利之・橘高敦史
- Organizer
  日本ビタミン学会第71回大会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] 変異型VDRを導入したくる病モデルラットにおけるVDRリガンドの骨形成作用2019
- Author(s)
  西川美宇・阿部圭祐安田佳織・真野寛生高野真史・橘高敦史生城真一・榊利之
- Organizer
  第92回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19H02889
[Presentation] ビタミンDバイオセンサーを用いたCYP27B1活性の新規評価方法2018
- Author(s)
  真野寛生、生城真一、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第70回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 変異型VDR導入くる病モデルラットにおける25-ヒドロキシビタミンD3の骨形成作用2018
- Author(s)
  阿部圭祐, 西川美宇, 安田佳織, 高松将士, 堀部恭平, 真野寛生,中川公恵, 津川尚子, 岡野登志夫, 生城真一,　榊利之
- Organizer
  日本生化学会第91回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 含フッ素ビタミンD誘導体群の合成2018
- Author(s)
  川越文裕、安田佳織、上杉志成、榊　利之、橘高敦史
- Organizer
  第44回　反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] SYNTHESIS OF 2-[2-(TETRAZOL-2-YL)ETHYL]-1a,25-DIHYDROXY-19-NORVITAMIN D3 AND ITS METABOLISM.2018
- Author(s)
  M Takano, K Yasuda, H Mano, T Sakaki, and A Kittaka
- Organizer
  21th Vitamin D Workshop
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法により作製した遺伝子改変ラットを用いたビタミンDの代謝および作用メカニズムの解明2018
- Author(s)
  榊利之
- Organizer
  第4回Neo Vitamin D Workshop学術集会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ビタミンD関連遺伝子改変ラットを用いた新規ビタミンD作用機序の解明2018
- Author(s)
  西川美宇、安田佳織、阿部圭祐 ,高松将士, 堀部恭平, 真野寛生,中川公恵, 津川尚子, 岡野登志夫, 生城真一,　榊利之
- Organizer
  日本生化学会第91回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 代謝酵素に高い抵抗性を持つビタミンD誘導体の合成研究2018
- Author(s)
  上野滉一、川越文裕、安田佳織、上杉志成、榊　利之、橘高敦史
- Organizer
  第62回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法で作製したVDR遺伝子改変ラットの表現型解析による新規ビタミンD作用メカニズムの解明2018
- Author(s)
  堀部恭平、西川美宇、安田佳織、阿部圭祐、真野寛樹、中川公恵、津川尚子、岡野登志夫、生城真一　榊利之
- Organizer
  日本ビタミン学会第70回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP24A1遺伝子欠損ラットへの25-ヒドロキシビタミンＤ3代謝様式解明2018
- Author(s)
  安田佳織・西川美宇岡本海利・高松将士阿部圭祐・真野寛生中川公恵・津川尚子岡野登志夫・生城真一榊利之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 遺伝子改変ラットを用いたビタミンDの代謝および作用メカニズムの解明2018
- Author(s)
  安田佳織、西川美宇、阿部圭祐、岡本海利、堀部恭平、真野寛生、中川公恵、津川尚子、岡野登志夫、生城真一、榊利之
- Organizer
  日本生化学会第91回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法で作製した変異型VDR導入ラットにおける25(OH)ビタミンD3およびビタミンD誘導体の活性評価2018
- Author(s)
  阿部圭祐、西川美宇、安田佳織、真野寛生、堀部恭平、橘高敦史、高野真史、中川公恵、岡野登志夫、生城真一,　榊利之
- Organizer
  日本ビタミン学会第70回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法で作出したCYP27B1遺伝子欠損およびビタミンD受容体遺伝子改変ラットを用いたビタミンD作用メカニズムの解明2018
- Author(s)
  西川美宇・安田佳織高松将士・阿部圭祐堀部恭平・岡本海利真野寛生・中川公恵津川尚子・岡野登志夫生城真一・榊利之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K14904
[Presentation] CYP24A1遺伝子欠損ラットへの25-ヒドロキシビタミンＤ3代謝様式解明2018
- Author(s)
  安田佳織・西川美宇岡本海利・高松将士阿部圭祐・真野寛生中川公恵・津川尚子岡野登志夫・生城真一榊利之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K14904
[Presentation] 23位置換基付加型25-ヒドロキシビタミンD3の代謝と生理作用2018
- Author(s)
  岡本海利、安田佳織、真野寛生、西川美宇、橘高敦史、高野真史、生城真一,　榊利之
- Organizer
  日本ビタミン学会第70回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] Generation of genetically modified rats in CYP27B1, CYP24A1 or vitamin D receptor gene by CRISPR/Cas9 system to reveal molecular mechanism of vitamin D2018
- Author(s)
  T. Sakaki
- Organizer
  14th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法で作出したCYP27B1遺伝子欠損およびビタミンD受容体遺伝子改変ラットを用いたビタミンD作用メカニズムの解明2018
- Author(s)
  西川美宇・安田佳織高松将士・阿部圭祐堀部恭平・岡本海利真野寛生・中川公恵津川尚子・岡野登志夫生城真一・榊利之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法により作製した遺伝子改変ラットを用いたビタミンD作用メカニズムの解明2018
- Author(s)
  榊利之
- Organizer
  第３５９回脂溶性ビタミン総合研究委員会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法で作製したビタミンD関連遺伝子改変ラットを用いた新規ビタミンD作用機序の解明2018
- Author(s)
  西川美宇、安田佳織、高松将士、阿部圭祐、岡本海利、堀部恭平、真野寛生、橘高敦史、高野真史、中川公恵、岡野登志夫、生城真一、榊利之
- Organizer
  日本ビタミン学会第70回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 25-ヒドロキシビタミンD3代謝物とその誘導体の合成研究2018
- Author(s)
  川越文裕、安田佳織、上杉志成、榊　利之、橘高敦史
- Organizer
  第62回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP24A1遺伝子改変ラットを用いた25-ヒドロキシビタミンD3の代謝解明2018
- Author(s)
  岡本海利、安田佳織、真野寛生、西川美宇、橘高敦史、高野真史、生城真一,　榊利之
- Organizer
  日本生化学会第91回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] アゾール基を有するビタミンＤ誘導体のCYP24A1による代謝2017
- Author(s)
  遠山枝李・安田佳織真野寛生・鎌倉昌樹生城真一・高野真史橘高敦史・太田美穂榊利之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP24A1遺伝子欠損ラットを用いた25-ヒドロキシビタミンD3代謝様式の解明2017
- Author(s)
  安田佳織・西川美宇岡本海利・高松将士阿部圭祐・真野寛生中川公恵・津川尚岡野登志夫・生城真一榊利之
- Organizer
  日本薬物動態学会　第32回年会
- Data Source
  KAKENHI-PROJECT-16K14904
[Presentation] ゲノム編集法で作成したVDR改変ラットにおける25(OH)ビタミンの作用2017
- Author(s)
  阿部圭祐・西川美宇安田佳織・真野寛生高松将士・中川公恵津川尚子・岡野登志夫生城真一・榊利之
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 高感度かつ短時間にビタミンD誘導体の親和性を評価する方法の開発2017
- Author(s)
  真野寛生・生城真一高野真史・橘高敦史榊利之
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-16K14904
[Presentation] ビタミンD誘導体AH-1のCYP24A1代謝物24位エピマーの合成2017
- Author(s)
  高野真史・安田佳織真野寛生・遠山枝李榊利之・橘高敦史
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP27B1　遺伝子欠損ラットにおける 25(OH)ビタミンD３の代謝と生理作用2017
- Author(s)
  高松将士・西川美宇安田佳織・阿部圭祐真野寛生・中川公恵津川尚子・岡野登志夫生城真一・榊利之
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP24A1遺伝子欠損ラットを用いた25-ヒドロキシビタミンD3代謝様式の解明2017
- Author(s)
  安田佳織・西川美宇岡本海利・高松将士阿部圭祐・真野寛生中川公恵・津川尚岡野登志夫・生城真一榊利之
- Organizer
  日本薬物動態学会　第32回年会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP27B1 independent 1alpha-hydroxylation of 25-hydroxyvitamin D3 in CYP27B1 deficient animals2017
- Author(s)
  M. Nishikawa K. Yasuda M. Takamatsu K. Abe K. Nakagawa N. Tsugawa T. Okano S. Ikushiro T. Sakaki
- Organizer
  20th International Conference on Cytochrome P450
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] VDR, CYP27B1, CYP24A1改変ラットにおける血中ビタミンD代謝物分析2017
- Author(s)
  安田佳織・西川美宇岡本海利・中川公恵津川尚子・岡野登志夫生城真一・榊利之
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP27B1遺伝子欠損マウスおよびラットにおける25-ヒドロキシビタミンD3投与の影響2017
- Author(s)
  安田佳織・西川美宇高松将士・阿部圭祐生城真一・中川公恵津川尚子・岡野登志夫榊利之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP24A1遺伝子欠損ラットへの25-ヒドロキシビタミンＤ3代謝様式解明2017
- Author(s)
  岡本海利・安田佳織西川美宇・高松将士阿部圭祐・真野寛生中川公恵・津川尚子岡野登志夫・生城真一榊利之
- Organizer
  分子生物学会・生化学会合同年会2018
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法で作出したCYP27B1遺伝子欠損およびビタミンD受容体遺伝子改変ラットを用いたビタミンD作用メカニズムの解明2017
- Author(s)
  西川美宇・安田佳織高松将士・阿部圭祐堀部恭平・岡本海利真野寛生・中川公恵津川尚子・岡野登志夫生城真一・　榊利之
- Organizer
  分子生物学会・生化学会合同年会2018
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] LC/MS/MSを利用した血中ビタミンＤ代謝物の一斉分析法の確立2017
- Author(s)
  安田佳織・岡本海利西川美宇・高松将士阿部圭祐・真野寛生中川公恵・津川尚子岡野登志夫・生城真一榊利之
- Organizer
  分子生物学会・生化学会合同年会2018
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] (24S)-2α-[2-(テトラゾール-2-イル)エチル]-1α,24,25-トリヒドロキシビタミンD3の合成2017
- Author(s)
  高野真史・安田佳織真野寛生・遠山枝李榊利之・橘高敦史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] LC/MS/MSを利用した血中ビタミンＤ代謝物の一斉分析法の確立2017
- Author(s)
  安田佳織・岡本海利西川美宇・高松将士阿部圭祐・真野寛生中川公恵・津川尚子岡野登志夫・生城真一榊利之
- Organizer
  分子生物学会・生化学会合同大会2017
- Data Source
  KAKENHI-PROJECT-16K14904
[Presentation] ゲノム編集法で作出したＩ型くる病モデルＣＹＰ27Ｂ1遺伝子欠損ラットへの25-ヒドロキシビタミンＤ3の投与効果2017
- Author(s)
  堀部恭平・西川美宇安田佳織・高松将士阿部圭祐・岡本海利真野寛生・中川公恵津川尚子・岡野登志夫生城真一・榊利之
- Organizer
  分子生物学会・生化学会合同大会2017
- Data Source
  KAKENHI-PROJECT-16K14904
[Presentation] Comparison of 25-hydroxyvitamin D3 metabolism between wild-type and CYP24A1-knockout rats2017
- Author(s)
  K. Yasuda M. Nishikawa K. Okamoto K. Nakagawa N. Tsugawa T. Okano S. Ikushiro T. Sakaki
- Organizer
  20th International Conference on Cytochrome P450
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] Characterization of CYP27B1 or CYP24A1 knockout rats generated by CRISPR/Cas9 system2017
- Author(s)
  T. Sakaki
- Organizer
  20th International Conference on Cytochrome P450
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] ゲノム編集法で作出したCYP27B1KOおよび変異型VDR導入ラットの比較による25D3の生理作用機序解明2017
- Author(s)
  阿部圭祐・西川美宇安田佳織・高松将士堀部恭平・岡本海利真野寛生・中川公恵津川尚子・野登志夫生城真一・榊利之
- Organizer
  分子生物学会・生化学会合同年会2018
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 2位置換基上にアゾールを有するビタミンD3誘導体の合成2017
- Author(s)
  高野真史・安田佳織真野寛生・遠山枝李榊利之・橘高敦史
- Organizer
  第3回Neo Vitamin D Workshop学術集会
- Data Source
  KAKENHI-PROJECT-16K14904
[Presentation] ゲノム編集法を用いたVDR、CYP27B1、CYP24A1遺伝子改変ラットの創製2017
- Author(s)
  西川美宇・安田佳織高松将士・阿部圭祐岡本海利・真野寛生中川公恵・津川尚子岡野登志夫・生城真一榊利之
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 抱合代謝酵素発現出芽酵母を用いたビタミンE代謝物抱合体調製技術の開発2016
- Author(s)
  高平梨可、岩本明日夏、西川美宇、安田佳織、鎌倉昌樹、榊利之、生城真一
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山市
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] 薬物代謝酵素発現酵母を用いたフラボノイド代謝物調製法2016
- Author(s)
  西川美宇、藤井美春、藤森成美、生城真一、榊利之
- Organizer
  第21回日本フードファクター学会学術集会
- Place of Presentation
  富山市
- Year and Date
  2016-11-19
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] CYP24A1はビタミンD誘導体開発における鍵酵素である2016
- Author(s)
  榊　利之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 2α-[2-(テトラゾール-2-イル)エチル]-1α,24,25-トリヒドロキシビタミンD3の合成2016
- Author(s)
  高野真史、安田佳織、遠山枝李、榊利之、橘高敦史
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 薬物代謝酵素によるセサミン代謝物の解析2016
- Author(s)
  岡本海利、安田佳織、伊藤香澄、上野千来、西川美宇、生城真一、榊利之
- Organizer
  第21回日本フードファクター学会学術集会
- Place of Presentation
  富山市
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] ゲノム編集法を用いたCYP27B1遺伝子欠損ラットの創製2016
- Author(s)
  西川美宇、安田佳織、高松将士、阿部圭祐、鎌倉昌樹、生城真一、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 2α位にアゾール基を有するビタミンＤ誘導体の代謝および骨密度上昇作用メカニズムの解明2016
- Author(s)
  遠山枝李、安田佳織、真野寛生、鎌倉昌樹、生城真一、太田美穂、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 骨粗鬆症治療薬への応用を目指したビタミンＤ誘導体の CYP24A1 による代謝2016
- Author(s)
  遠山枝李、安田佳織、真野寛生、鎌倉昌樹、生城真一、太田美穂、高野真史、橘高敦史、榊利之
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  仙台
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP27B1遺伝子欠損マウスにおける25-ヒドロキシビタミンD3の代謝解析2016
- Author(s)
  安田佳織、西川美宇、高松将士、生城真一、中川公恵、津川尚子、岡野登志夫、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 抱合酵素発現酵母株を用いたメチル化ケルセチンの代謝解析2016
- Author(s)
  生城真一、岩本明日夏、藤井美春、西川美宇、濱田昌弘、中島範行、安田佳織、榊利之
- Organizer
  第10回日本ポリフェノール学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-08-04
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] 分割型ルシフェラーゼを用いたビタミンD受容体リガンド検出バイオセンサーの応用2016
- Author(s)
  真野寛生・西川美宇安田佳織・生城真一高野真史・橘高敦史榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Invited
- Data Source
  KAKENHI-PROJECT-16K14904
[Presentation] 分割型ルシフェラーゼを用いたビタミンD受容体リガンド検出バイオセンサーの応用2016
- Author(s)
  真野寛生、西川美宇、安田佳織、生城真一、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP27B1ノックアウトマウスを用いた25-ヒドロキシビタミンDの生理作用の検討2016
- Author(s)
  西川美宇、田中一丸、生城真一、鎌倉昌樹、中川公恵、津川尚子、岡野登志夫、榊利之
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP27B1ノックアウトマウスにおける25-ヒドロキシビタミンD3の代謝解析2016
- Author(s)
  西川美宇、安田佳織、高松将士、青木健悟、生城真一、中川公恵、津川尚子、岡野登志夫、榊利之
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP27B1 遺伝子欠損マウスを用いた 25-ヒドロキシビタミン D3 の生理作用の検証2016
- Author(s)
  高松将士、西川美宇、安田佳織、阿部圭祐、中川公恵、岡野登志夫、津川尚子、生城真一、榊利之
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 薬用植物由来有効成分であるペンタガロイルグルコースのグルクロン酸抱合代謝2016
- Author(s)
  藤井美春、西川美宇、小池りりい、米澤裕子、生城真一、榊利之
- Organizer
  第21回日本フードファクター学会学術集会
- Place of Presentation
  富山市
- Year and Date
  2016-11-19
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] 骨粗鬆症あるいは癌治療薬への応用を目指したビタミンＤ誘導体の代謝様式の解明2016
- Author(s)
  遠山枝李・安田佳織真野寛生・鎌倉昌樹生城真一・太田美穂高野真史・橘高敦史榊利之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP27B1ノックアウトマウスへの25-ヒドロキシビタミンD3投与による骨形成および雌性生殖機能への影響2016
- Author(s)
  阿部圭祐・西川美宇高松将士・安田佳織生城真一・中川公恵津川尚子・岡野登志夫榊利之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] 強い骨密度上昇作用を有するビタミンD誘導体の代謝様式の解明2016
- Author(s)
  遠山枝李・安田佳織生城真一・鎌倉昌樹高野真史・橘高敦史榊利之
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] CYP27B1遺伝子欠損マウスを用いた 25-ヒドロキシビタミン D3 生理作用の検証2016
- Author(s)
  高松将士、西川美宇、安田佳織、阿部圭祐、中川公恵、岡野登志夫、津川尚子、生城真一、榊利之
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H04912
[Presentation] Whole cell-dependent production of equol metabolites using genetically engineered budding yeast.2015
- Author(s)
  Ikushiro S, Kataoka M, Nishikawa M, Yasuda M, Hamada M, Nakajima N, Murota K, Uehara M, Kamakura M, Toshiyuki S
- Organizer
  ICoFF2015
- Place of Presentation
  Souel, Korea
- Year and Date
  2015-11-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] Protein engineering of CYP105A1 to produce active forms of2015
- Author(s)
  Yuya Yogo, Kaori Yasuda, Teisuke Takita, Hiroshi Sugimoto, Yoshitsugu Shiro, Hiroki Mano, Keiko Hayashi, Masaki Kamakura, Miho Ohta, Shinichi lkushiro, Kiyoshi Yasukawa, Toshiyuki Sakaki
- Organizer
  The 19th International Conference on Cytochrome P450
- Place of Presentation
  Tokyo
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 異物代謝における種差同定を目指した異物代謝酵素発現酵母株の構築2015
- Author(s)
  生城真一、西川美宇、榊利之
- Organizer
  2015年　日本毒性学会学術年会
- Place of Presentation
  金沢、石川
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] 放線菌由来CYP105A1の三重変異体（R73A/R84A/M239X）の大腸菌での発現とビタミンD2と7-メトキシクマリンに対する酵素活性2015
- Author(s)
  余語祐哉、安田佳織、滝田禎亮、杉本宏、城宜嗣、真野寛生、林恵子、鎌倉昌樹、太田美穂、生城真一、保川清、榊利之
- Organizer
  日本農芸化学会中部・関西合同支部会
- Place of Presentation
  富山
- Year and Date
  2015-08-18
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP27B1ノックアウトマウスを用いた25-ヒドロキシビタミンD3の骨形成及び生殖機能に対する生理作用の検討2015
- Author(s)
  西川美宇、田中一丸、安田佳織、青木健悟、高松将士、生城真一、中川公恵、津川尚子、岡野登志夫、榊利之
- Organizer
  第38回日本分子生物学会、第88回日本生化学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 放線菌由来CYP105A1変異体を用いたビタミンD水酸化体および医薬品代謝物の生産2015
- Author(s)
  安田佳織、余語祐哉、滝田禎亮、保川清、杉本宏、城宜嗣、真野寛生、太田美穂、生城真一、榊利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP24A1-dependent metabolism of a vitamin D analog which has a potent ability to increase bone mineral density2015
- Author(s)
  Eri Tohyama, Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Masashi Takano, Atsushi Kittaka, Toshiyuki Sakaki
- Organizer
  “Metals in Biology” in Wako
- Place of Presentation
  Wako
- Year and Date
  2015-06-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 強い骨密度上昇作用を有するビタミンD誘導体の代謝様式の解明2015
- Author(s)
  遠山枝李、安田佳織、生城真一、鎌倉昌樹、高野真史、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 活性型ビタミンDや医薬品代謝物を生産するCYP105A1の機能解析2015
- Author(s)
  余語祐哉、安田佳織、滝田禎亮、杉本宏、城宜嗣、真野寛生、林恵子、鎌倉昌樹、太田美穂、生城真一、保川清、榊利之
- Organizer
  日本農芸化学会中部・関西合同支部会
- Place of Presentation
  富山
- Year and Date
  2015-08-18
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP105A1の立体構造に基づく機能改変と医薬品生産への応用2015
- Author(s)
  余語祐哉、安田佳織、滝田禎亮、杉本宏、城宜嗣、真野寛生、林恵子、鎌倉昌樹、太田美穂、生城真一、保川清、榊利之
- Organizer
  第38回日本分子生物学会、第88回日本生化学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP27B1ノックアウトマウスにおける25-ヒドロキシビタミンD3の代謝解析2015
- Author(s)
  安田佳織、西川美宇、田中一丸、生城真一、鎌倉昌樹、中川公恵、津川尚子、岡野登志夫、榊利之
- Organizer
  第38回日本分子生物学会、第88回日本生化学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP27B1ノックアウトマウスを用いた25-ヒドロキシビタミンD3の生理作用の検討2015
- Author(s)
  西川美宇、田中一丸、生城真一、鎌倉昌樹、中川公恵、津川尚子、岡野登志夫、榊利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] Whole cell-dependent synthesis of flavonoid metabolites using genetically engineered yeast cells2015
- Author(s)
  Nishikawa M,Ikushiro S, Fujimori N, Fujii M, Koike R, Sakaki T
- Organizer
  ICoFF2015
- Place of Presentation
  Souel, Korea
- Year and Date
  2015-11-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] 分割型ルシフェラーゼを用いたビタミンDバイオセンサーの開発2015
- Author(s)
  真野寛生,　西川美宇、安田佳織、鎌倉昌樹、生城真一,　高野真史、斉藤　望、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP24A1-dependent metabolism of a promising vitamin D analog for osteoporosis treatment2015
- Author(s)
  Eri Tohyama, Kaori Yasuda, Masaki Kamakura, Shinichi Ikushiro, Masashi Takano, Atsushi Kittaka, Toshiyuki Sakaki
- Organizer
  The 19th International Conference on Cytochrome P450
- Place of Presentation
  Tokyo
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP24A1 is a key enzyme to develop vitamin D analogs as anti-osteoporosis or anti-cancer drugs2015
- Author(s)
  Toshiyuki Sakaki, Kaori Yasuda, Shinichi Ikushiro, Keiko Yamamoto,
- Organizer
  The 19th International Conference on Cytochrome P450
- Place of Presentation
  Tokyo
- Year and Date
  2015-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP27B1ノックアウトマウスを用いた25-ヒドロキシビタミンD3の生理作用に関する研究2015
- Author(s)
  青木健悟、西川美宇、高松将士、田中一丸、安田佳織、中川公恵、津川尚子、岡野登志夫、生城真一、榊利之
- Organizer
  日本農芸化学会中部・関西合同支部会
- Place of Presentation
  富山
- Year and Date
  2015-08-18
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP27B1ノックアウトマウスを用いた 25-ヒドロキシビタミンD3の生理作用の検討2015
- Author(s)
  榊利之
- Organizer
  第一回ネオビタミンDワークショップ
- Place of Presentation
  奈良
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 哺乳動物由来異物代謝酵素発現酵母を用いたポリフェノール抱合代謝物調製2014
- Author(s)
  生城真一、榊利之
- Organizer
  第8回日本ポリフェノール学会学術年会
- Place of Presentation
  東京
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] Microbial Production of Hydroxylated Forms of Vitamin D2013
- Author(s)
  K. Yasuda, M. Endo, K. Hayashi, S. Ilkushiro, M. Kamakura, M. Ohta, T. Sakaki
- Organizer
  Enzyme Engineering XXII
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] Whole cell-dependent production of polyphenol conjugates using genetically engineered budding yeast2013
- Author(s)
  S. Ikushiro, M. Nishikawa, T. Sakaki
- Organizer
  第6回国際ポリフェノール学会
- Place of Presentation
  ブエノスアイレス
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] ヒト由来CYP2R1発現酵母におけるUV照射による25-ヒドロキシビタミンD2の生産2013
- Author(s)
  安田　佳織、遠藤　真理子、生城　真一、鎌倉　昌樹、太田美穂、榊　利之
- Organizer
  日本ビタミン学会第65回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 薬物代謝酵素発現酵母を用いたヒト医薬品代謝物調製2013
- Author(s)
  西川美宇、増山優香、安田佳織、小路征　、鎌倉昌樹、生城真一、榊利之
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] Whole cell-dependent production of polyphenol conjugates using genetically engineered budding yeast2013
- Author(s)
  S. Ikushiro, M. Nishikawa, T. Sakaki
- Organizer
  第6回国際ポリフェノール学会
- Place of Presentation
  ブエノスアイレス
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] POSSIBLE APPLICATION OF BACTERIAL AND MAMMALIAN VITAMIN D HYDROXYLASES2013
- Author(s)
  Toshiyuki Sakaki
- Organizer
  18th International Conference on Cytochrome P450
- Place of Presentation
  Seattle, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] ラットを用いたセサミンと医薬品の相互作用の解析2013
- Author(s)
  上野千来、安田佳織、西川美宇、生城真一、鎌倉昌樹、榊利之
- Organizer
  第18回日本フードファクター学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 異物代謝酵素発現酵母を用いたポリフェノール抱合代謝物の調製2013
- Author(s)
  生城真一、小路征、西川美宇、鎌倉昌樹、榊利之
- Organizer
  日本ビタミン学会第65回
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] P450発現菌体を用いたビタミンD水酸化体の生成2013
- Author(s)
  安田佳織、林恵子、生城　真一、杉本　宏、城　宜嗣、鎌倉昌樹、榊　利之
- Organizer
  2013年度　酵素・補酵素研究会
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP27B1ノックアウトマウス腎臓近位尿細管初代培養細胞における25-ヒドロキシビタミンD3の生理作用2013
- Author(s)
  田中一丸、西川　美宇、山下　成彬、宗綱　栄二、河南　理恵、生城　真一、鎌倉　昌樹、太田美穂、中川　公恵、廣田　佳久、岡野　登志夫、前田　尚之、榊　利之
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] セサミンと医薬品の相互作用2013
- Author(s)
  上野千来、安田佳織、西川美宇、生城真一、鎌倉昌樹、榊利之
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 異物抱合酵素発現酵母を用いたフラボノイド抱合体の調製2013
- Author(s)
  生城真一、長谷川嵩、黒田将司、西川美宇、鎌倉昌樹、榊利之
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] ビタミンD 1α位水酸化酵素CYP27B1遺伝子欠損マウスを用いたビタミンD作用の解析2013
- Author(s)
  (1) 西川　美宇、山下　成彬、宗綱　栄二、河南　理恵、生城　真一、鎌倉　昌樹太田　美穂、中川　公恵、廣田　佳久、岡野登志夫、前田尚之、榊　利之、
- Organizer
  日本ビタミン学会第65回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] C5-C6 Coupling of MART-10 Synthesis and Its Clinical Implication in Cancer Treatment and Prevention2013
- Author(s)
  Masashi Takano, Kun-Chun Chiang, Horng-Heng Juang, Kaori Yasuda, Toshiyuki Sakaki, Toshimasa Itoh, Keiko Yamamoto, Daisuke Sawada, John N. Flanagan, Gunnar Norstedt, Tai C. Chen, and Atsushi Kittaka
- Organizer
  第10回カルボアニオン化学国際会議（ISCC-10、同志社大学）
- Place of Presentation
  同志社大学
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 活性型ビタミンD_3誘導体の2a側鎖上の二級水酸基の効果と生物活性評価2012
- Author(s)
  高野真史、榊利之、橘高敦史(他11名)
- Organizer
  日本薬学会第132年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 1α,4,25-トリヒドロキシビタミンD_3の合成とヒト水酸化酵素による代謝に関する研究2012
- Author(s)
  澤田大介、榊利之、橘高敦史, 他5名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 1a, 4, 25-トリヒドロキシビタミンD_3の合成とヒト水酸化酵素による代謝に関する研究2012
- Author(s)
  澤田大介、榊利之、橘高敦史(他5名)
- Organizer
  日本薬学会第132年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Whole cell-dependent production of drug metabolites using genetically engineered budding2012
- Author(s)
  Shinichi Ikushiro, Miyu Nishikawa, and Toshiyuki Sakaki
- Organizer
  P450発見50周年記念シンポジウム
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 出芽酵母発現系を用いた医薬品・食品代謝物調製技術の確立2012
- Author(s)
  西川美宇、生城真一、長谷川嵩、榊利之
- Organizer
  日本ビタミン学会第64回大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 哺乳動物由来UDP-グルクロン酸転移酵素発現出芽酵母を用いた抱合体産生2012
- Author(s)
  長谷川　嵩、西川　美宇、生城　真一、榊　利之
- Organizer
  2012年度農芸化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] ヒト由来硫酸基転移酵素発現出芽酵母を用いた抱合体産生2012
- Author(s)
  生城　真一、布目　基倫、西川　美宇、榊　利之
- Organizer
  2012年度農芸化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] Construction of sequential drug metabolizing system by CYP and UGT using genetically engineered yeast.2012
- Author(s)
  Miyu Nishikawa, Yuuka Masuyama, Kaori Yasuda, Takashi Hasegawa, Masaki Kamakura, Toshiyuki Sakaki and Shinichi Ikushiro
- Organizer
  日本薬物動態学会第２７回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] Difference of substrate recognition between human CYP3A4 and CYP2C19 based on metabolite identification and in silico prediction2012
- Author(s)
  城谷直紀、榊利之、生城真一、赤松美紀
- Organizer
  第18回ヨーロッパ構造活性相関シンポジウム
- Place of Presentation
  ギリシャ、ロードス島,ロードスパレス国際コンベンションセンター.
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] 遺伝子改変出芽酵母を用いた食品成分代謝物調製技術の開発2012
- Author(s)
  生城真一、西川美宇、増山優香、鎌倉昌樹、榊利之
- Organizer
  第17回日本フードファクター学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 活性型ビタミンD_3誘導体の2α側鎖上の二級水酸基の効果と生物活性評価2012
- Author(s)
  高野真史、榊利之、橘高敦史, 他11名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 薬物代謝酵素発現酵母株を用いた医薬品代謝物調製技術の開発2012
- Author(s)
  西川　美宇、増山　優香、長谷川　嵩、鎌倉　昌樹、榊　利之、生城　真一
- Organizer
  2012年度農芸化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] ヒト前立腺細胞における25-ヒドロキシビタミンDの細胞増殖抑制作用2011
- Author(s)
  宗綱栄二、榊利之, 他4名
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒト前立腺細胞における25-ヒドロキシビタミンDの細胞増殖抑制作用2011
- Author(s)
  宗綱栄二、榊利之(他4名)
- Organizer
  第84回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] グルクロン酸抱合酵素系発現酵母を用いた抱合体合成2011
- Author(s)
  西川美宇、増山優香、長谷川嵩、鎌倉昌樹、榊利之、生城真一
- Organizer
  第84回　日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] Preparation of sulfates using genetically engineered budding yeast2011
- Author(s)
  Shinichi Ikushiro, Miyu Nishikawa, Motomichi Nunome, Yuuka Masuyama, Masaki Kamakura, and Toshiyuki Sakaki
- Organizer
  JSSX2011（日本薬物動態学会）
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] hCYP24A1代謝抵抗性活性型ビタミンD_3誘導体の合成とATRA耐性APL細胞への活性評価2011
- Author(s)
  高野真史, 榊利之, 橘高敦史, 他11名
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ビタミンDによる細胞増殖抑制の作用機構2011
- Author(s)
  宗綱栄二、榊利之, 他4名
- Organizer
  日本ビタミン学会第63回大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Production of Glucurono- or Sulfo-conjugated Metabolites Using Genetically Engineered Yeast Expressing CYP with UGT or SULT2011
- Author(s)
  Toshiyuki Sakaki, Yuuka Masuyama, Motomichi Nunome, Yumi Takano, Kaori Yasuda, Masaki Kamakura, and Shinichi Ikushiro
- Organizer
  17thInternational Conference on Cytochrome P450(招待講演)
- Place of Presentation
  Manchester, UK
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] Whole cell-dependent production of acyl glucuronide using genetically engineered budding yeast2011
- Author(s)
  Miyu Nishikawa, Yuuka Masuyama, Takashi Hasegawa,Masaki Kamakura, Toshiyuki Sakaki, and Shinichi Ikushiro
- Organizer
  JSSX2011（日本薬物動態学会）
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] Whole cell-dependent production of dietary conjugated metabolites using genetically engineered budding yeast2011
- Author(s)
  Shinichi Ikushiro, Miyu Nishikawa, Yuuka Masuyama, Masaki Kamakura, and Toshiyuki Sakaki
- Organizer
  ICoFF2011（第5回食品因子国際会議）
- Place of Presentation
  台北、台湾
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 活性型ビタミンD_3誘導体エルデカルシトール(ED-71)の代謝に関わる酵素の同定2011
- Author(s)
  榊利之
- Organizer
  第332回脂溶性ビタミン委員会
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Whole cell-dependent production of dietary conjugated metabolites using genetically engineered budding yeast ICoFF20112011
- Author(s)
  Shinichi Ikushiro, Miyu Nishikawa, Yuuka Masuyama, Masaki Kamakura, and Toshiyuki Sakaki
- Organizer
  第5回食品因子国際会議
- Place of Presentation
  台北
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 2α位に置換基を有するビタミンD誘導体のヒト体内における代謝予測2011
- Author(s)
  安田佳織、橘高敦史、榊利之, 他8名
- Organizer
  日本ビタミン学会第63回大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒトCYP3A4およびCYP2C19のTebufenozide代謝における立体選択性の差異2011
- Author(s)
  城谷直紀、榊利之、生城真一、赤松美紀
- Organizer
  日本農薬学会第36回大会
- Place of Presentation
  日本農薬学会第36回大会
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] ラットおよびヒトCYPlAlによるポリ塩化ビフェニルの代謝と3次元構造の比較2011
- Author(s)
  薮未来、榊利之, 他9名
- Organizer
  第20回環境化学討論会
- Place of Presentation
  熊本、熊本県立大学
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] 出芽酵母発現系を用いた硫酸抱合体調製技術の開発2011
- Author(s)
  生城真一、西川美宇、布目基倫、増山優香、鎌倉昌樹、榊利之
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 出芽酵母発現系を用いた硫酸抱合体調製技術の開発2011
- Author(s)
  生城真一、西川美宇、布目基倫、増山優香、鎌倉昌樹、榊利之
- Organizer
  第84回　日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23580179
[Presentation] 2α位に置換基を有するビタミンD誘導体のヒト体内における代謝予測2011
- Author(s)
  安田佳織、生城真一、鎌倉昌樹、高野真史、齋藤望、橘高敦史、太田美穂、榊利之
- Organizer
  日本ビタミン学会第63回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒトCYP3A4およびCYP2C19のTebufenozide代謝における立体選択性の差異2011
- Author(s)
  城谷直紀、榊利之、生城真一、赤松美紀, 他4名
- Organizer
  日本農薬学会第36回大会
- Place of Presentation
  東京、玉川大学
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] ビタミンDによる細胞増殖抑制の作用機構2011
- Author(s)
  宗綱栄二、河南理恵、太田美穂、安田佳織、生城真一、榊利之
- Organizer
  日本ビタミン学会第63回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] セサミンおよびエピセサミンのヒト体内における代謝予測2011
- Author(s)
  安田佳織、生城真一、榊利之, 他5名
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都、国立京都国際会館
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] ラットおよびヒトCYP1A1によるポリ塩化ビフェニルの代謝と3次元構造の比較2011
- Author(s)
  薮未来、榊利之
- Organizer
  第20回環境化学討論会
- Place of Presentation
  熊本,熊本県立大学
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] セサミンおよびエピセサミンのヒト体内における代謝予測2011
- Author(s)
  安田佳織、生城真一、榊利之
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都,国立京都国際会館
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] hCYP24A1代謝抵抗性活性型ビタミンD_3誘導体の合成とATRA耐性APL細胞への活性評価2011
- Author(s)
  高野真史, 榊利之, 橘高敦史(他11名)
- Organizer
  日本薬学会第131年会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 変異VDR(Arg274Leu)に対するセコステロイドリガンドの設計と合成2010
- Author(s)
  本澤忍、高橋尚志, 橘高敦史, 榊利之, 他14名
- Organizer
  第329回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒト前立腺細胞における25-hydroxy-19-nor vitamin D_3の作用機構2010
- Author(s)
  宗綱栄二, 橘高敦史, 榊利之, (他7名)
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22659043
[Presentation] CYP105A1二重変異体によるビタミンD_3の代謝とその反応機構2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之(他5名)
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒト前立腺細胞における25-hydroxy-19-nor vitamin D_3の作用機構2010
- Author(s)
  宗綱栄二, 橘高敦史, 榊利之(他7名)
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒト代謝酵素CYP3A4とCYP2C19の基質認識機構における差異-Tebufenozideを例として-2010
- Author(s)
  城谷直紀、榊利之、生城真一、赤松美紀, 他7名
- Organizer
  日本農薬学会第35回大会
- Place of Presentation
  札幌、北海道大学
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] 代謝物同定およびin silico予測を用いたCYP3A4とCYP2C19における基質認識機構の差異2010
- Author(s)
  城谷直紀、榊利之、生城真一、赤松美紀
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島,徳島大学
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] ラットおよびヒトCYP1A1による3,3',4,4'-テトラクロロビフェニルの代謝能の比較2010
- Author(s)
  薮未来、榊利之
- Organizer
  日本分子生物学会・日本生化学会合同会議
- Place of Presentation
  兵庫,神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] Synthesis of a series of vitamin D analogs as ligands for human vitamin D receptor : super agonists, antagonists, and studies on metabolism2010
- Author(s)
  Atsushi Kittaka, Daisuke Sawada, Toshiyuki Sakaki, 他11名
- Organizer
  環太平洋国際化学会議
- Place of Presentation
  ハワイ
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 25-ヒドロキシビタミンD_3による細胞増殖抑制の作用メカニズム2010
- Author(s)
  榊利之
- Organizer
  第328回脂溶性ビタミン総合研究委員会
- Place of Presentation
  神戸
- Year and Date
  2010-07-12
- Data Source
  KAKENHI-PROJECT-22659043
[Presentation] 代謝物同定およびin silico予測を用いたCYP3A4とCYP2C19における基質認識機構の差異2010
- Author(s)
  城谷直紀、榊利之、生城真一、赤松美紀, 他4名
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島、徳島大学
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] 改変型シトクロムP450を発現する放線菌を用いた活性型ビタミンDの生産2010
- Author(s)
  榊利之
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] レチノイン酸耐性ヒト前骨髄球性白血病細胞の分化誘導におけるCYP24A1抵抗性新規ビタミンD誘導体の有用性2010
- Author(s)
  松本直樹、榊利之、橘高敦史(他3名)
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 25-ヒドロキシビタミンD_3による細胞増殖抑制の作用メカニズム2010
- Author(s)
  榊利之
- Organizer
  第328回脂溶性ビタミン総合研究委員会
- Year and Date
  2010-07-12
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ビタミンDによる細胞増殖抑制の作用機構2010
- Author(s)
  宗綱栄二、生城真一、榊利之(他6名)
- Organizer
  日本ビタミン学会第62回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] CYP105A1二重変異体によるビタミンD_3の代謝とその反応機構2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之, 他5名
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ビタミンD誘導体の軟骨細胞分化に対する作用～CYP27B1 knockoutマウスを用いた解析2010
- Author(s)
  中川公恵, 礒元啓吾, 木村州作, 榊利之, 岡野登志夫, (他2名)
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-22659043
[Presentation] ヒト代謝酵素CYP3A4とCYP2C19の基質認識機構における差異-Tebufenozideを例として2010
- Author(s)
  城谷直紀、榊利之、生城真一、赤松美紀
- Organizer
  日本農薬学会第35回大会
- Place of Presentation
  札幌,北海道大学
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] 変異VDR(Arg274Leu)に対するセコステロイドリガンドの設計と合成2010
- Author(s)
  本澤忍、高橋尚志, 橘高敦史、榊利之(他14名)
- Organizer
  第329回脂溶性ビタミン総合研究委員会
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ビタミンDによる細胞増殖抑制の作用機構2010
- Author(s)
  宗綱栄二、生城真一、榊利之, 他6名
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Difference of substrate recognition between human CYP3A4 and CYP2C19 based onmetabolite identification and in silico prediction2010
- Author(s)
  城谷直紀、榊利之、生城真一、赤松美紀, 他4名
- Organizer
  第18回ヨーロッパ構造活性相関シンポジウム
- Place of Presentation
  ギリシャ、ロードス島ロードスパレス国際コンベンションセンター
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] レチノイン酸耐性ヒト前骨髄球性白血病細胞の分化誘導におけるCYP24A1抵抗性新規ビタミンD誘導体の有用性2010
- Author(s)
  松本直樹、榊利之、橘高敦史, 他3名
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Production of Glucuronides Using Genetically Engineered Yeast Expressing CYP and UC2010
- Author(s)
  榊利之, 他
- Organizer
  10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
- Place of Presentation
  Woodhole, USA
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-20580138
[Presentation] Synthesis of a series of vitamin D an alogs as ligands for human vitamin D receptor : super agonists, antagonists, and studies on metabolism2010
- Author(s)
  Atsushi Kittaka, Daisuke Sawada, Toshiyuki Sakaki(他11名)
- Organizer
  環太平洋国際化学会議
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ビタミンDによる細胞増殖抑制の作用機構2010
- Author(s)
  宗綱栄二, 生城真一, 榊利之, (他6名)
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-22659043
[Presentation] ラットおよびヒトCYP1A1による3,3',4,4'-テトラクロロビフェニルの代謝能の比較2010
- Author(s)
  薮未来、榊利之, 他7名
- Organizer
  BMB2010(日本分子生物学会・日本生化学会合同会議)
- Place of Presentation
  神戸、ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22510229
[Presentation] CYP105A1二重変異体発現放線菌によるビタミンD_3の代謝2010
- Author(s)
  安田佳織, 杉本宏, 橘高敦史, 榊利之, 他5名
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] PPROTE-N ENGINEERING OF VITAMIN D HYDROXYLASES2010
- Author(s)
  Toshiyuki Sakaki
- Organizer
  The 5^<th> International Conference GPBNM2010
- Place of Presentation
  St.Petersburg (Russia)
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒト前立腺細胞における25-hydroxy-19-nor vitamin D_3の作用機構2010
- Author(s)
  宗綱栄二, 橘高敦史, 榊利之, 他7名
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] PPROTEIN ENGINEE RING OF VITAMIN D HYDROXYLASES2010
- Author(s)
  Toshiyuki Sakaki
- Organizer
  The 5^<th> International Conference GPBNM2010
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 活性型ビタミンD_3誘導体における核内受容体 Water Channel の維持と生物活性2009
- Author(s)
  高野真史, 澤田大介, 林恵子, 生城真一, 榊利之, 角田真二, 高木健一郎, 堀江恭平, 上村みどり, 竹之内一弥, 杉浦隆之, 野尻久雄, 橘高敦司
- Organizer
  日本ビタミン学会第61回大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] 活性型ビタミンD_3誘導体における核内受容体Water Channelの維持と生物活性2009
- Author(s)
  高野真史, 澤田大介, 林恵子, 生城真一, 榊利之, 橘高敦司(他7名)
- Organizer
  日本ビタミン学会第61回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Mechanism of inhibition of cell proliferation by vitamin D32009
- Author(s)
  Sakaki T
- Organizer
  第2回博多シンポジウム
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒト前立腺由来細胞における25-hydroxyvitaminD3の代謝と細胞増殖抑制作用2009
- Author(s)
  宗綱栄二, 池田進ノ介, 河南理恵, 中林佐知栄, 太田美穂・鎌倉昌樹, 生城真一, 榊利之
- Organizer
  第82回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ビタミンDを代謝するシトクロムP450の構造と機能および医療への応用2009
- Author(s)
  榊利之
- Organizer
  第82回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Construction of a highlyactive vitamin D hydroxylase based on crystal structure of CYP105A1 and its application to production of 1α, 25-dihydroxyvitamin D_32009
- Author(s)
  榊利之
- Organizer
  第16回シトクロムP450国際会議
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Mechanism of inhibition of cell proliferation by vitamin D32009
- Author(s)
  榊利之
- Organizer
  第2回博多シンポジウム「内外環境と生物応答」
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] CYP105A1二重変異体を発現する放線菌を用いた活性型ビタミンD_3の生産2009
- Author(s)
  林恵子, 安田佳織, 生城真一, 鎌倉昌樹, 城宜嗣, 太田美穂, 榊利之
- Organizer
  日本ビタミン学会第61回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヒトおよびラット由来CYP24A1による1α, 25-ジヒドロキシビタミンD_2の代謝2009
- Author(s)
  漆野奈穂子, 安田佳織, 生城真一, 鎌倉昌樹, 太田美穂, 榊利之
- Organizer
  日本ビタミン学会第61回大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Construction of a highlyactive vitamin D hydroxylase based on crystal structure of CYP105A1 and its application to production of 1α, 25-dihydroxyvitamin D_32009
- Author(s)
  Sakaki T
- Organizer
  第16回シトクロムP450国際会議
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] SYNTHESIS, METABOLISM, AND BIOLOGICAL ACTIVITY OF 2-[3-(TETRAZOLYL)PROPYL]- 1α,25-DIHYDROXY-19-NORVITAMIN D3
- Author(s)
  M. Takano, E. Higuchi, K. Yasuda, E. Tohyama, A. Takeuchi, T. Sakaki, and A. Kittaka
- Organizer
  18th Vitamin D Workshop
- Place of Presentation
  デルフト市、オランダ
- Year and Date
  2015-04-21 – 2015-04-24
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] ヒト由来メチルステロール酸化酵素SC4MOLによるビタミンD誘導体の代謝
- Author(s)
  安田佳織、岩永　由麻、小川　和亮、高野真史、橘高敦史、太田美穂、鎌倉　昌樹、生城　真一、榊　利之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 強い骨密度上昇作用を有するビタミンD誘導体の代謝様式の解明
- Author(s)
  遠山枝李、安田佳織、生城真一、鎌倉昌樹、高野真史、橘高敦史、榊　利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05 – 2015-06-06
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] ヒト血中濃度レベルのケルセチンおよびケルセチン抱合体の抗炎症作用
- Author(s)
  黒川健治、額恵理香、大西康太、生城真一、榊利之、紀再思、坪井洋、寺尾純二、河合慶親
- Organizer
  第19回日本フードファクター学会
- Place of Presentation
  鹿児島
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] 異物代謝酵素発現酵母を用いたエクオール抱合代謝解析
- Author(s)
  生城真一、片岡真衣、西川美宇、安田佳織、室田佳恵子、上原万里子、鎌倉昌樹、榊利之
- Organizer
  日本ビタミン学会第66回大会
- Place of Presentation
  姫路
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] 分割型ルシフェラーゼを用いたビタミンDバイオセンサーの開発
- Author(s)
  真野寛生、西川美宇、安田佳織、鎌倉昌樹、生城真一、　高野真史、斉藤　望、橘高敦史、榊利之
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05 – 2015-06-06
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1α,2α,25-, 1α,4α,25- AND 1α,4β,25-TRIHYDROXYVITAMIN D3 WITH METABOLIC STUDIES
- Author(s)
  M. Takano, D. Sawada, K. Yasuda, M. Nishikawa, A. Takeuchi, K. Takagi, K. Horie, G.S. Reddy, T.C. Chen, T. Sakaki, and A. Kittaka
- Organizer
  17th Vitamin D Workshop
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-06-17 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] メチルステロール酸化酵素SC4MOLによる2位置換基付加型ビタミンD誘導体の代謝
- Author(s)
  安田佳織、岩永由麻、小川和亮、生城真一、鎌倉昌樹、高野真史、齋藤　望、橘高敦史、藤島利江、太田美穂、榊　利之
- Organizer
  日本ビタミン学会第66回大会
- Place of Presentation
  姫路商工会議所
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] CYP27B1ノックアウトマウス腎臓近位尿細管初代培養細胞における25-ヒドロキシビタミンD3の生理作用
- Author(s)
  田中一丸、西川　美宇、真野　寛生、山下　成彬、宗綱　栄二、河南　理恵、生城　真一、鎌倉　昌樹、太田美穂、中川　公恵、廣田　佳久、岡野　登志夫、前田　尚之、榊　利之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 25-ヒドロキシビタミンDの生理機能
- Author(s)
  西川　美宇、泉　憲人、生城　真一、鎌倉　昌樹、太田　美穂、榊　利之
- Organizer
  日本ビタミン学会
- Place of Presentation
  姫路
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP105A1変異体発現Rhodococcus属放線菌を用いたビタミンD水酸化体の生産
- Author(s)
  余語祐哉、安田佳織、林恵子、杉本宏、滝田禎亮、保川清、安武義晃、田村具博、太田美穂、鎌倉昌樹、生城真一、榊利之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] Microbial production of hydroxylated metabolites of vitamin D
- Author(s)
  Kaori Yasuda, Yuya Yogo, Keiko Hayashi, Mariko Endo, Masaki Kamakura, Miho Ohta, Yoshiaki Yasutake, Tomohiro Tamura, Shinichi Ikushiro and Toshiyuki Sakaki
- Organizer
  12th International Symposium on cytochrome P450 Biodiversity and Biotechnology
- Place of Presentation
  京都
- Year and Date
  2014-09-24 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 2α-(3-ヒドロキシプロピル)活性型ビタミンD3（MART-10）の合成と制がん活性
- Author(s)
  高野真史，Kun-Chun Chiang，安田佳織，榊利之，Tai C. Chen，橘高敦史
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] Protein engineering of actinomycete CYP105A1
- Author(s)
  Teisuke Takita, Kaori Yasuda, Yuya Yogo, Hiroshi Sugimoto, Yoshitsugu Shiro Keiko Hayashi, Hiroki Mano, Masaki Kamakura, Miho Ohta, Shinichi Ilkushiro, Kiyoshi Yasukawa, Toshiyuki Sakaki
- Organizer
  12th International Symposium on cytochrome P450 Biodiversity and Biotechnology
- Place of Presentation
  京都
- Year and Date
  2014-09-24 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 強い骨密度上昇作用を有するビタミンD誘導体の代謝様式の解明
- Author(s)
  遠山枝李、安田佳織、鎌倉　昌樹、生城　真一、高野真史、橘高敦史、榊　利之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] CYP105A1三重変異体発現Rhodococcus属放線菌を用いたビタミンD水酸化体の生産
- Author(s)
  余語祐哉、安田佳織、真野寛生、林恵子、杉本宏、滝田禎亮、保川清、安武義晃、田村具博、太田美穂、鎌倉昌樹、生城真一、榊利之
- Organizer
  農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 2位にテトラゾリルプロピル基を有する19-ノル活性型ビタミンD3の合成と代謝
- Author(s)
  樋口恵理香，安田佳織，高野真史，榊　利之，橘高敦史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] MART-10 Has Enhanced Chemotherapeutic Potency- in vitro and in vivo Pre-clinical Studies
- Author(s)
  K.C. Chiang, A. Kittaka, J.N. Flanagan, T. Sakaki, G. Norstedt and T.C. Chen
- Organizer
  5th International Symposium Vitamin D and Analogs in Cancer Prevention and Therapy
- Place of Presentation
  Krefeld, Germany
- Year and Date
  2014-05-02 – 2014-05-03
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] 異物代謝酵素発現酵母を用いたエクオール抱合代謝物の調製
- Author(s)
  生城真一、片岡真衣、西川美宇、安田佳織、室田佳恵子、上原万里子、鎌倉昌樹、榊利之
- Organizer
  第19回日本フードファクター学会
- Place of Presentation
  鹿児島
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-26292072
[Presentation] 2α位にトリアゾリルプロピル基を有する19-ノル型ビタミンD3の合成と生物活性評価
- Author(s)
  高野真史，樋口恵理香，安田佳織，榊　利之，橘高敦史
- Organizer
  日本ビタミン学会第67回大会
- Place of Presentation
  奈良
- Year and Date
  2015-06-05 – 2015-06-06
- Data Source
  KAKENHI-PROJECT-24590021
[Presentation] メチルステロール酸化酵素SC4MOLによる2位置換基付加型ビタミンD誘導体の代謝
- Author(s)
  安田佳織、岩永　由麻、小川　和亮、生城　真一、鎌倉　昌樹、高野真史、齋藤　望、橘高敦史、藤島利江、太田美穂、榊　利之
- Organizer
  日本ビタミン学会
- Place of Presentation
  姫路
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] ヒト由来メチルステロール酸化酵素SC4MOLの機能解析
- Author(s)
  小川　和亮、安田佳織、岩永　由麻、太田美穂、鎌倉　昌樹、生城　真一、榊　利之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25292062
[Presentation] 出芽酵母発現系を用いたカニクイザル由来UDP-グルクロン酸転移酵素の機能解析
- Author(s)
  高平梨可、宇野泰広、池中良徳、石塚真由美、西川美宇、榊利之、生城真一
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26292072

1. IKUSHIRO Shinichi (50244679)

# of Collaborated Projects: 9 results

# of Collaborated Products: 185 results
2. KITTAKA Atsushi (00214833)

# of Collaborated Projects: 5 results

# of Collaborated Products: 94 results
3. INOUYE Kuniyo (10223249)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TAKITA Teisuke (70263126)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. YASUDA KAORI (70707231)

# of Collaborated Projects: 3 results

# of Collaborated Products: 41 results
6. NISHIKAWA MIYU (90749805)

# of Collaborated Projects: 3 results

# of Collaborated Products: 53 results
7. 中川公恵 (90309435)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
8. SUGIMOTO Hiroshi (90344043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. AKAMATSU Miki (70183134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
10. TAKANO Masashi (50386611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
11. SAWADA Daisuke (00338691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. SUGIYAMA Toru (40242036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KANO KENJI (10152828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. YASUTAKE YOSHIAKI (20415756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. TAMURA TOMOHIRO (30357488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. SAITO Izumu (70158913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KATO Shigeaki (60204468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OKANO Toshio (20131542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
19. 太田美穂 (90132935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 川尻要 (50142112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 室田佳恵子 (40294681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. 岡田只士 (30623855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MANO HIROKI

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
24. IKENAKA Yoshinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. INUI Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 戸田佳織

# of Collaborated Projects: 0 results

# of Collaborated Products: 35 results
27. 石塚真由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 水川葉月

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 中山翔太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 上杉志成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 鎌倉昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
32. 津川尚子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 須原義智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 廣田佳久

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

SAKAKI Toshiyuki 榊 利之

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ビタミンDの消化管炎症に対する関りと新規炎症性腸疾患治療戦略Ongoing

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Elucidation of vitamin D actions using genetically modified rats and application of vitamin D analogs to medical drugsPrincipal InvestigatorOngoing

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Construction of evaluation system for vitamin D analogs using genetically modified rats with genome editingPrincipal Investigator

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Development of highly sensitive detection system for active form of vitamin DPrincipal Investigator

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Advanced use of vitamin D hydroxylasesPrincipal Investigator

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25-ヒドロキシビタミンD3のホルモン作用の解析Principal Investigator

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Protein Engineering of vitamin D hydroxylases and design of their inhibitors based on their tertiary structurePrincipal Investigator

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Ahレセプターの生理的意義と内在性リガンドの生成機構Principal Investigator

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Construction of evaluation system for vitamin D analogsPrincipal Investigator

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SAKAKI Toshiyuki 榊利之

[Book] ビタミンDと疾患　(ビタミンDの代謝：ｐｐ60-68）2014