Kawagoe Fumihiro 川越文裕

… Alternative Names

KAWAGOE FUMIHIRO 川越文裕

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Researcher Number	00756520
Other IDs
Affiliation (Current)	2026: 東京理科大学, 理学部第二部化学科, 助教
Affiliation (based on the past Project Information) *help	2026: 東京理科大学, 理学部第二部化学科, 助教 2024: 東京理科大学, 理学部第二部化学科, 助教 2022 – 2023: 帝京大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Basic Section 33020:Synthetic organic chemistry-related Except Principal Investigator Basic Section 38050:Food sciences-related
Keywords	Principal Investigator 医薬品 / 合成 / ライブラリー / IL19 / 乾癬 / ビタミンD / SREBP / CYP24A1 / ビタミンD受容体 / 創薬 … More / フッ素 / フッ素化ビタミンD / VDR / 生物活性 / 側鎖 / 構造活性相関 / フッ素化 / ビタミンD誘導体 … More Except Principal Investigator ビタミンD欠乏 / ビタミンD誘導体 / 炎症性腸疾患 / ビタミンD Less

ビタミンDの新活性：非ホルモン様作用の探索と創薬研究Principal Investigator
- Principal Investigator
  
  川越文裕
- Project Period (FY)
  2026 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Tokyo University of Science
ビタミンDによる抗炎症機構の解明および炎症性腸疾患との関連
- Principal Investigator
  
  岡田只士
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Okayama Gakuin University
Development of an efficient synthesis method for fluorinated vitamin D3, library construction, and biological activityPrincipal Investigator
- Principal Investigator
  
  KAWAGOE FUMIHIRO
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 33020:Synthetic organic chemistry-related
- Research Institution
  Tokyo University of Science
  Teikyo University

All 2025 2024 2023 2022

All Journal Article Presentation Patent

[Journal Article] An Improved and Scalable Synthesis of the Potent SREBP Inhibitor KK-052 via [3+2] Cycloaddition2024
- Author(s)
  Kittaka Atsushi、Kawagoe Fumihiro、Mototani Sayuri、Takemoto Yasushi、Uesugi Motonari
- Journal Title
  
  Synthesis
  
  Volume: 56 Issue: 09 Pages: 1460-1464
- DOI
  10.1055/a-2236-0413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05354, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-22K14688
[Journal Article] Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D3: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life2023
- Author(s)
 Kawagoe Fumihiro、Mototani Sayuri、Yasuda Kaori、Mano Hiroki、Takeuchi Akiko、Saitoh Hiroshi、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 71 Issue: 9 Pages: 717-723
- DOI
 10.1248/cpb.c23-00395
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2023-09-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-23K23530
[Journal Article] Synthesis of (22R)-, (22S)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D3 and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism2023
- Author(s)
 Kawagoe Fumihiro、Mototani Sayuri、Yasuda Kaori、Takeuchi Akiko、Mano Hiroki、Kakuda Shinji、Saitoh Hiroshi、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
 
 The Journal of Organic Chemistry
 
 Volume: 88 Issue: 17 Pages: 12394-12408
- DOI
 10.1021/acs.joc.3c01134
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-23K23530
[Journal Article] Structure?activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-0522023
- Author(s)
  Kawagoe Fumihiro、Mototani Sayuri、Mendoza Aileen、Takemoto Yasushi、Uesugi Motonari、Kittaka Atsushi
- Journal Title
  
  RSC Medicinal Chemistry
  
  Volume: 14 Issue: 10 Pages: 2030-2034
- DOI
  10.1039/d3md00352c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-22K05354, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556
[Journal Article] Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination2023
- Author(s)
  Kawagoe Fumihiro、Mototani Sayuri、Kittaka Atsushi
- Journal Title
  
  Biomolecules
  
  Volume: 14 Issue: 1 Pages: 37-37
- DOI
  10.3390/biom14010037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-22K14688
[Journal Article] 23,25-Dihydroxyvitamin D3 is liberated as a major vitamin D3 metabolite in human urine after treatment with β-glucuronidase: Quantitative comparison with 24,25-dihydroxyvitamin D3 by LC/MS/MS2022
- Author(s)
  Takada Kazunari、Hagiwara Yukino、Togashi Moeka、Kittaka Atsushi、Kawagoe Fumihiro、Uesugi Motonari、Nishimoto-Kusunose Shoichi、Higashi Tatsuya
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 223 Pages: 106133-106133
- DOI
  10.1016/j.jsbmb.2022.106133
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K23530, KAKENHI-PROJECT-22H00350
[Journal Article] The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities2022
- Author(s)
  Mototani Sayuri、Kawagoe Fumihiro、Yasuda Kaori、Mano Hiroki、Sakaki Toshiyuki、Kittaka Atsushi
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 16 Pages: 5352-5352
- DOI
  10.3390/molecules27165352
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-23K23530
[Patent] 特願2024
- Inventor(s)
  谷津智史,宮田佳樹,橘髙敦史,川越文裕,本谷小佑里,赤木祐介
- Industrial Property Rights Holder
  谷津智史,宮田佳樹,橘髙敦史,川越文裕,本谷小佑里,赤木祐介
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-22K14688
[Patent] 脂質生合成を選択的に阻害するビタミンD誘導体2023
- Inventor(s)
  上杉志成　竹本靖　長澤和夫　橘髙敦史　川越文裕など
- Industrial Property Rights Holder
  上杉志成　竹本靖　長澤和夫　橘髙敦史　川越文裕など
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-517858
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K14688
[Patent] 特開2023
- Inventor(s)
  橘高敦史　川越文裕
- Industrial Property Rights Holder
  橘高敦史　川越文裕
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-22K14688
[Patent] ＣＤ環側鎖置換ビタミンＤ誘導体含有ＩＬ－１９分泌抑制剤2023
- Inventor(s)
  川越文裕 , 橘髙敦史
- Industrial Property Rights Holder
  川越文裕 , 橘髙敦史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-068498
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K14688
[Patent] ＣＤ環側鎖置換ビタミンＤ誘導体含有ＩＬ－１９分泌抑制剤2023
- Inventor(s)
  橘髙敦史　川越文裕
- Industrial Property Rights Holder
  橘髙敦史　川越文裕
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-068498
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K14688
[Patent] 脂質生合成を選択的に阻害するビタミンD誘導体2023
- Inventor(s)
  上杉志成、竹本靖、長澤和夫, 橘高敦史 , 川越文裕,など
- Industrial Property Rights Holder
  上杉志成、竹本靖、長澤和夫, 橘高敦史 , 川越文裕,など
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-517858
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 長さの異なる側鎖にジフルオロ部位が導入された25-ヒドロキシビタミンD3誘導体の合成2025
- Author(s)
  川越　文裕、田淵　紘矢、本谷　小佑里、安田　佳織、谷津　智史、藤島　利江、宮田　佳樹、木村　力、榊　利之、橘高　敦史
- Organizer
  日本薬学会第146回年会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] ヒトケラチノサイトからのIL-19分泌を抑制する側鎖フッ素化19-ノル型ビタミンD3誘導体ライブラリー構築と生物活性評価2025
- Author(s)
  本谷小佑里、川越文裕、真野寛生、安田佳織、藤島利江、榊利之、橘高敦史
- Organizer
  日本薬学会第146回年会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] ビタミンD受容体変異に起因するⅡ型くる病に対する新規リガンドの探索と応用2025
- Author(s)
  岡本侑樹、真野寛生、川越文裕、高野真史、木瀬智子、藪花奈、村田崇真、西川美宇、生城真一、橘高敦史、榊利之、安田佳織
- Organizer
  日本薬学会第146回年会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 変異型ビタミンD受容体に高い親和性を有する新規誘導体の探索2024
- Author(s)
  岡本侑樹, 真野寛生, 川越文裕, 高野真史, 西川美宇, 生城真一, 橘高敦史, 榊利之, 安田佳織
- Organizer
  日本ビタミン学会７６回大会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 極微量で作用選択的なビタミンD誘導体の開発研究2024
- Author(s)
  橘高敦史、川越文裕、本谷小佑里、谷津智史、宮田佳樹、藤島利江、安田佳織、榊利之
- Organizer
  MARC×湘南アイパーク第2回シーズ発表会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 未定2024
- Author(s)
  川越文裕
- Organizer
  第十三回フッ素若手の会
- Invited
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 側鎖にフッ素を導入した19-ノル型ビタミンD 3 誘導体ライブラリー構築と生物活性評価2024
- Author(s)
  本谷小佑里、川越文裕、安田佳織、藤島利江、榊利之、橘高敦史
- Organizer
  第４１回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] フッ素化ビタミンDの可能性2024
- Author(s)
  川越文裕
- Organizer
  第１３回フッ素化学若手の会
- Invited
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 眼科疾患を標的としたビタミンD誘導体の開発2024
- Author(s)
  谷津智史、川越文裕、本谷小佑里、橘高敦史、宮田佳樹
- Organizer
  MARC×湘南アイパーク第2回シーズ発表会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 側鎖フッ素化ビタミンD3誘導体ライブラリー構築と生物活性評価2024
- Author(s)
  本谷小佑里、川越文裕、安田佳織、藤島利江、榊　利之、橘高敦史
- Organizer
  第68回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 22位フッ素化ビタミンD3の合成と基本的生物活性2024
- Author(s)
  川越文裕、本谷小佑里、安田佳織、竹内明子、真野寛生、齋藤　博、藤島利江、榊　利之、橘高敦史
- Organizer
  第381回脂溶性ビタミン総合研究委員会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 22位がフッ素化された25-ヒドロキシビタミンD3誘導体の合成2023
- Author(s)
  川越文裕本谷小佑里安田佳織榊利之橘高敦史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] Comprehensive synthesis of side-chain fluorinated vitamin D3 derivatives and their stability to hCYP24A1-dependent catabolism2023
- Author(s)
  川越文裕
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] Synthesis of 22,22-difluoro-25-hydroxyvitamin D3 and effects of side chain fluorination on vitamin D receptor binding affinity and CYP24A1-dependent metabolism2023
- Author(s)
  川越文裕
- Organizer
  AMEX2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] (22R)-および(22S)-フルオロ-25- ヒドロキシビタミンD3の立体選択的合成2022
- Author(s)
  川越文裕、本谷小佑里、安田佳織、榊　利之、橘高敦史
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 24位がヒドロキシ化された23,23- ジフルオロビタミンD3誘導体の合成2022
- Author(s)
  川越文裕本谷小佑里安田佳織榊利之橘高敦史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] Comprehensive synthesis of side-chain fluorinated vitamin D3 analogues： Construction of chemical library and exploration of drug candidates2022
- Author(s)
  川越文裕、本谷小佑里、安田佳織、榊　利之、橘高敦史
- Organizer
  Asia Pacific Society for Materials Research 2022 Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] ビタミンD3側鎖22位への立体選択的フッ素導入法開発2022
- Author(s)
  川越文裕、本谷小佑里、安田佳織、榊　利之、橘高敦史
- Organizer
  日本ビタミン学会第74回大会
- Data Source
  KAKENHI-PROJECT-22K14688
[Presentation] 22位フッ素化ビタミンD3誘導体の立体選択的合成2022
- Author(s)
  川越文裕、本谷小佑里、安田佳織、榊　利之、橘高敦史
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K14688

1. 岡田只士 (30623855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 安田佳織 (70707231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KITTAKA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 竹本靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawagoe Fumihiro 川越 文裕

KAWAGOE FUMIHIRO 川越 文裕

Research Projects

Research Products

Co-Researchers

ビタミンDの新活性：非ホルモン様作用の探索と創薬研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ビタミンDによる抗炎症機構の解明および炎症性腸疾患との関連

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an efficient synthesis method for fluorinated vitamin D3, library construction, and biological activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] An Improved and Scalable Synthesis of the Potent SREBP Inhibitor KK-052 via [3+2] Cycloaddition2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D<sub>3</sub>: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Synthesis of (22<i>R</i>)-, (22<i>S</i>)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D<sub>3</sub> and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure?activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-0522023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 23,25-Dihydroxyvitamin D3 is liberated as a major vitamin D3 metabolite in human urine after treatment with β-glucuronidase: Quantitative comparison with 24,25-dihydroxyvitamin D3 by LC/MS/MS2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities2022

Author(s)

Journal Title

DOI

Data Source

[Patent] 特願2024

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 脂質生合成を選択的に阻害するビタミンD誘導体2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 特開2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Kawagoe Fumihiro 川越文裕

KAWAGOE FUMIHIRO 川越文裕

[Presentation] 22位がフッ素化された25-ヒドロキシビタミンD3誘導体の合成2023