SUGIMOTO Toshitsugu 杉本利嗣

Researcher Number	00226458
Affiliation (based on the past Project Information) *help	2018: 島根大学, 学術研究院医学・看護学系, 教授 2010 – 2017: 島根大学, 医学部, 教授 2004 – 2007: Shimane University, Faculty of Medicine, 医学部, 教授 2001 – 2004: Kobe University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 2000: 神戸大学, 医学部, 助教授 … More 1995 – 1998: 神戸大学, 医学部, 助手 1992 – 1993: 神戸大学, 医学部, 助手 1990: Kobe University School of Medicine, Research Associate, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Endocrinology / Endocrinology / General internal medicine(including psychosomatic medicine) / General internal medicine (including Psychosomatic medicine) Except Principal Investigator 内分泌・代謝学 / Endocrinology / General internal medicine (including Psychosomatic medicine) / Kidney internal medicine / Endocrinology
Keywords	Principal Investigator 副甲状腺ホルモン / 骨芽細胞 / 骨形成 / Parathyroid hormone / Bone formation / Wnt / Osteoblast / アポトーシス / TGFβ / 骨吸収 … More / 骨リモデリング / カルシウム感知受容体 / Smad3 / 骨形成因子 / Smad / グルココルチコイド / スタチン / ビスフォスフォネート / IGF-I / Insulin-like growth factor-binding protein-5 / Estrogen / エストロゲン / Bone resorption / Differentiation / Bone morphogenetic protein / Bone remodeling / 破骨細胞 / 分化 / 骨代謝 / ストロンチウム / βカテニン / 筋芽細胞 / 骨粗鬆症 / 筋代謝 / 内分泌学 / FAM5C / 椎体骨折 / スクレロスチン / オステオカルシン / 筋肉 / グルコース / サルコペニア / 筋骨連関 / オステオグリシン / AGEs / Smart / strontium / Stalin / Bisohosohonate / Lunt / smad / Calcium-sencing receptor / Statin / Bisphosphonate / smad-3 / ビスホスホネート / smad3 / Insulin-like growth factor I / Apoptosis / Smad-3 / Hyperparathyroidism / Polymorphism / Vitamin D receptor / Proliferation / Bone / Parathyroid / Calcium-sensing receptor / 続発性副甲状腺機能亢進症 / 原発性副甲状腺機能亢進症 / 家族性低カルシウム尿性高カルシウム血症 / 副甲状腺機能亢進症 / 遺伝子多型 / ビタミンD受容体 / 増殖 / 骨 / 副甲状腺 / Postmenopausal osteoporosis / cAMP-dependent protein kinase / Insulin-like growth factor-l / cAMP依存性プロテインキナーゼ / インスリン様成長因子結合タンパク / 閉経後骨粗鬆症 / CAMP依存性プロテインキナーゼ / インスリン様成長因子結合蛋白 / インスリン様成長因子 / Proteoglycan / Osteoclast / プロテオグリカン / Cacitonin / Insulin-like growth factor-1 / Calcium / Monocyte / 化学走化性 / カルチトニン / インスリン様成長因子1 / カルシウム / 単球 / 骨リモデリンク / 骨折 / GIP / GLP-1 / DPP-4 / インクレチン / MAPキナーゼ / 終末糖化産物 / 小胞体ストレス / Tmem119 / 老年医学 … More Except Principal Investigator 副甲状腺ホルモン / 骨芽細胞 / Parathyroid Hormone(PTH) / JunD / Smad / Menin / TGF-beta / C-Kinase / Osteoblasts / Kidney / OK Cells / UMR-106 Cells / Degradation / Proteolytic Enzyme / Cーキナーゼ / カテプシン / VMRー106細胞 / キモトクプシン様酵素 / アルカリフオスファタ-ゼ / サイクリツクAMP / OK細胞 / 副甲状腺ホルモン断片 / 2.8 / ROS17 / N末端 / C末端 / 水解酵素 / 情報伝達機搆 / アルカリフォスファタ-ゼ / キモトリプシン / UMR106細胞 / アメリカふくろねずみ腎細胞(OK細胞) / 副甲状腺ホルモン(PTH) / ホルモン分解(Degradation) / parathyroid hormone / glucocorticoid / bone formation / osteoblast / アポトーシス / Smad3 / TGFβ / 分化 / 糖質コルチコイド / 骨形成 / 島根県 / 日本 / osteoporosis / 脂質異常症 / LDLコレステロール / 脂質 / 骨粗鬆症 / 血管内皮細胞 / 血管石灰化 / 血管平滑筋細胞 / 終末糖化産物 / 尿毒素 / オステオカルチン / アルカリファスターゼ / 石灰化 / カルシウム感知受容体 Less

Regulation of muscle metabolism by bonePrincipal Investigator
- Principal Investigator
  
  Sugimoto Toshitsugu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Shimane University
The regulation of bone metabolism by digestive tract: A study on the mechanism of incretin-induced bone formationPrincipal Investigator
- Principal Investigator
  
  Sugimoto Toshitsugu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Shimane University
Examination of relationships between serum levels of LDL cholesterol and bone metabolism-related indices as well as bone fracture
- Principal Investigator
  
  YAMAUCHI Mika
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Shimane University
Elucidation of bone formation signal aimed at the development of medical treatment of osteoporosis induced by deterioration of bone formationPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Toshitsugu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Shimane University
To clarify the mechanism of chronic kidney disease progression by uremic toxins and its application for the treatment
- Principal Investigator
  
  YANO Shozo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Shimane University
Research for the elucidation of bone formation signals applied to the development of bone-forming agentsPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Toshitsugu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Shimane University
Research for the mechanisms of anabokic action of bone-forming agents on bone for the development of treatment of osteoporosisPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Toshitsugu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Shimane University
Research of the signals of osteoblast differentiation and mineralization including menin and Smad
- Principal Investigator
  
  KAJI Hirohi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University
Research for the mechanisms of anabolic action of parathyroid hormone(PTH) on bone and interaction between PTH and estrogen in osteoblastsPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Toshitsugu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University
骨代謝・骨粗鬆症治療における骨芽細胞カルシウム感知受容体とその作動薬の役割の解明
- Principal Investigator
  
  YAMAGUCHI Toru
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University
Research for the role of calcium-sensing receptor in parathyroid gland and bonePrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Toshitsugu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University
Research for the mechanisms of anabolic action of parathyroid hormone (PTH) and interaction between PTH and estrogenPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Toshitsugu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
Research for role of bone morphogenetic protein in the differentiation and activation of osteoclast and osteoblastPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Toshitsugu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
Reseach for cell-cell communication in bone remodeling and differentiation of osteoblast and osteoclastPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Toshitsugu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
Enzymic Degradation of Parathyroid Hormone and Its Control
- Principal Investigator
  
  FUJITA Takuo
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University

[Book] ファーマナビゲーター　SERM編2013
- Author(s)
  山内美香、杉本利嗣
- Total Pages
  355
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23590882
[Book] 先制医療日本の未来を拓く医療：治療医学から先制医療へ骨粗鬆症2012
- Author(s)
  杉本　利嗣
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-22590656
[Book] 先制医療日本の未来を拓く医療:治療医学から先制医療へ:骨粗鬆症2012
- Author(s)
  杉本利嗣
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-22590656
[Book] 副甲状腺腫瘍の疫学2011
- Author(s)
  矢野彰三, 杉本利嗣
- Total Pages
  731
- Publisher
  日本臨床29(3):407-410,2011
- Data Source
  KAKENHI-PROJECT-20590974
[Book] 骨粗鬆症の予防と治療ガイドライン 2011年版2011
- Author(s)
  山内美香, 杉本利嗣
- Total Pages
  167
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-23590882
[Book] 骨粗鬆症の予防と治療ガイドライン2011年版2011
- Author(s)
  山内美香、杉本利嗣
- Total Pages
  167
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-23590882
[Book] 副甲状腺腫瘍の疫学.日本臨床69増刊号22011
- Author(s)
  矢野彰三, 杉本利嗣
- Data Source
  KAKENHI-PROJECT-20590974
[Book] 糖尿病と骨病変.CKD-MBDハンドブック(編著:深川雅史)2009
- Author(s)
  矢野彰三, 杉本利嗣
- Publisher
  日本メディカルセンター東京
- Data Source
  KAKENHI-PROJECT-20590974
[Book] 内科学原発性、二次性副甲状腺機能圧迫症2007
- Author(s)
  杉本利嗣
- Total Pages
  2008
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-18591025
[Book] 内科学、原発性、二次性副甲状腺機能大迫症2007
- Author(s)
  杉本利嗣
- Total Pages
  2008
- Publisher
  朝倉書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Book] ホルモンの事典副甲状腺ホルモン2004
- Author(s)
  杉本利嗣
- Total Pages
  700
- Publisher
  朝倉書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Journal Article] Association of Osteoglycin and FAM5C with Bone Turnover Markers, Bone Mineral Density, and Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes Mellitus2017
- Author(s)
  Tanaka KI, Kanazawa I, Kaji H, Sugimoto T
- Journal Title
  
  Bone
  
  Volume: 95 Pages: 5-10
- DOI
  10.1016/j.bone.2016.11.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09240
[Journal Article] Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus2016
- Author(s)
  Sayuri Tanaka, Ippei Kanazawa, Masakazu Notsu, Toshitsugu Sugimoto
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 未定
- NAID
  120006334822
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460899
[Journal Article] Serum dipeptidyl peptidase-4 is associated with multiple vertebral fractures in type 2 diabetes mellitus2016
- Author(s)
  Masakazu Notsu, Ippei Kanazawa, Sayuri Tanaka, Toshitsugu Sugimoto
- Journal Title
  
  Clinical Endocrinology
  
  Volume: 84 Issue: 3 Pages: 332-337
- DOI
  10.1111/cen.12971
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460899
[Journal Article] 2型糖尿病男性において血中DPP-4濃度高値は多発椎体骨折の危険因子である2015
- Author(s)
  野津雅和、金沢一平、田中小百合、杉本利嗣
- Journal Title
  
  Osteoporosis Japan
  
  Volume: 23 Pages: 46-50
- NAID
  120006870500
- Open Access
- Data Source
  KAKENHI-PROJECT-25460899
[Journal Article] Increased low-density lipoprotein cholesterol level is associated with non-vertebral fractures in postmenopausal women2014
- Author(s)
  Mika Yamauchi, Toru Yamaguch, Kiyoko Nawata, Ken-ichiro Tanaka, Shin Takaoka, Toshitsugu Sugimoto
- Journal Title
  
  Endocrine
  
  Volume: in press Issue: 1 Pages: 279-286
- DOI
  10.1007/s12020-014-0292-0
- NAID
  120005982748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590882
[Journal Article] Increased low-density lipoprotein cholesterol level is associated with non-vertebral fractures in postmenopausal women2014
- Author(s)
  Mika Yamauchi, Toru Yamaguchi, Kiyoko Nawata, Ken-ichiro Tanaka, Shin Takaoka, Toshitsugu Sugimoto
- Journal Title
  
  Endocrine
  
  Volume: (Epub ahead of print)
- NAID
  120005982748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590882
[Journal Article] Association of n-3 polyunsaturated fatty acid intake with bone mineral density in postmenopausal women2013
- Author(s)
  Nawata K, Yamauchi M, Takaoka S, Yamaguchi T, Sugimoto T
- Journal Title
  
  Calcif Tissue Int
  
  Volume: 93巻 Pages: 147-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590882
[Journal Article] Fracture risk is increased by the complication of hypertension and treatment with calcium channel blockers in postmenopausal women with type 2 diabetes2013
- Author(s)
  Takaoka S, Yamaguchi T, Tanaka K, Morita M, Yamamoto M, Yamauchi M, Yano S, Sugimoto T
- Journal Title
  
  J Bone Miner Metab
  
  Volume: 31巻 Pages: 102-107
- NAID
  10031168843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590882
[Journal Article] Association of n-3 polyunsaturated fatty acid intake with bone mineral density in postmenopausal women.2013
- Author(s)
  Nawata K, Yamauchi M, Takaoka S, Yamaguchi T, Sugimoto T.
- Journal Title
  
  Calcif Tissue Int
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590882
[Journal Article] 生活習慣病が骨へ与える影響2013
- Author(s)
  山内美香、杉本利嗣
- Journal Title
  
  実験治療
  
  Volume: 709巻 Pages: 3-8
- Data Source
  KAKENHI-PROJECT-23590882
[Journal Article] . Fracture risk is increased by the complication of hypertension and treatment with calcium channel blockers in postmenopausal women with type 2 diabetes2013
- Author(s)
  Takaoka S, Yamaguchi T, Tanaka K, Morita M, Yamamoto M, Yamauchi M, Yano S, Sugimoto T
- Journal Title
  
  J Bone Miner Metab
  
  Volume: 31 Issue: 1 Pages: 102-107
- DOI
  10.1007/s00774-012-0389-6
- NAID
  10031168843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590882, KAKENHI-PROJECT-25460900
[Journal Article] Vertebral fracture risk after once-weekly teriparatide injection-follow-up study of teriparatide once-weekly efficacy research (TOWER) trial2013
- Author(s)
  Sugimoto T, Shiraki M, Nakano T, Kishimoto H, Ito M, Fukunaga M, Hagino H, Sone T, Kuroda T, Nakamura T
- Journal Title
  
  Curr Med Res Opin
  
  Volume: 29 Pages: 195-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] FAM5C is a soluble osteoblast differentiation factor linking muscle to bone2012
- Author(s)
  Tanaka K, Matsumoto E, Higashimaki Y, Sugimoto T, Seino S, Kaji H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 418 Pages: 134-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] Role of osteoglycin in the linkage between muscle and bone2012
- Author(s)
  Tanaka K, Matsumoto E, Higashimaki Y, Katagiri T, Sugimoto T, Seino S, Kaji H
- Journal Title
  
  J Biol Chem
  
  Volume: 287(15) Pages: 11616-11628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] Smad7 inhibits differentiation and mineralization of mouse osteoblastic cells2012
- Author(s)
  Yano M, Inoue Y, Tobimatsu T, Hendy GN, Canaff L, Sugimoto T, Seino S, Kaji H
- Journal Title
  
  Endocr J
  
  Volume: 59(8) Pages: 653-662
- NAID
  10031064548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] 閉経後女性における高LDL血症の骨脆弱性に及ぼす影響2012
- Author(s)
  山内美香、山口徹、名和田清子、高岡伸、杉本利嗣
- Journal Title
  
  Osteoporosis Japan
  
  Volume: 20巻 Pages: 257-260
- Data Source
  KAKENHI-PROJECT-23590882
[Journal Article] Decreased PTH levels accompanied by low bone formation is associated with vertebral fractures in postmenopausal women with type 2 diabetes2012
- Author(s)
  Yamamoto M, Yamaguchi T, Nawata K, Yamauchi M, Sugimoto T
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 97 Pages: 1277-1284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] Decreased PTH levels accompanied by low bone formation is associated with vertebral fractures in postmenopausal women with type 2 diabetes2012
- Author(s)
  Yamamoto M, Yamaguchi T, Nawata K, Yamauchi M, Sugimoto T
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 97巻 Pages: 1277-1284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590882
[Journal Article] Randomized teriparatide [human parathyroid hormone(PTH)1-34]once-weekly efficacy research (TOWER)trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk2012
- Author(s)
  Nakamura T, Sugimoto T, Nakano T, Kishimoto H, Ito M, Fukunaga H, Hagino H, SoneT, Yoshikawa H, Nishizawa Y, Fujita T, Shiraki M
- Journal Title
  
  J Clin Endicrinol Metab
  
  Volume: 97(9) Pages: 3097-3106
- NAID
  120006985510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells2012
- Author(s)
  Tanaka K, Inoue Y, Hendy GN, Canaff L, Katagiri T, Kitazawa R, Komori T, Sugimoto T, Seino S, Kaji H
- Journal Title
  
  Bone
  
  Volume: 51 Pages: 158-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] Effects of a single injection of teriparatide on bone turnover barkers in postmenopausal women2012
- Author(s)
  Shiraki M, Sugimoto T, Nakamura T
- Journal Title
  
  Osteoporos Int
  
  Volume: 24 Pages: 219-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] Phenylacetic acid stimulates reactive oxygen species generation and tumor necrosis factor-a secretion in vascular ndothelial cells.2011
- Author(s)
  Morita M, Yano S, Yamaguchi T, Yamauchi M, Sugimoto T
- Journal Title
  
  Ther Apheresis Dial. 15(2)
  
  Pages: 147-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients with type 2 diabetes ellitus.2011
- Author(s)
  Kanazawa I, Yano S, Notsu Y, Yamaguchi T, Nabika T, Sugimoto T
- Journal Title
  
  Clin Endocrinol (Oxf). 74(4)
  
  Pages: 467-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Kaji H Novel parathyroid hormone-responsive smad3-related factor, Tmem119,promotes osteoblast differentiation2011
- Author(s)
  Hisa I, Inoue Y, Hendy GN, Canafi L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S
- Journal Title
  
  J Biol Chem
  
  Volume: 286(11) Pages: 9787-9796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization.2010
- Author(s)
  Takaoka S, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T
- Journal Title
  
  Horm Metab Res
  
  Volume: 42 Pages: 627-631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] Relationships between dimethylarginine and the presence of vertebral fractures in type 2 diabetes mellitus.2010
- Author(s)
  Kanazawa I, Yano S, Yamaguchi T, Notsu Y, Nabika T, Sugimoto T
- Journal Title
  
  Clin Endocrinol (Oxf). 73(4)
  
  Pages: 463-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Fasudil hydrochrolide induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression2010
- Author(s)
  Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T
- Journal Title
  
  Endocr J
  
  Volume: 57(5) Pages: 415-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590656
[Journal Article] 続発性骨粗鬆症における骨折リスク2010
- Author(s)
  矢野彰三, 杉本利嗣
- Journal Title
  
  CLINICAL CALCIUM Vol.19(9)
  
  Pages: 771-776
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Calcium-corrected Intact PTH : A Clinically Useful Parameter for Quantifying Parathyroid Function in Patients Undergoing Hemodialysis.2010
- Author(s)
  Yano S, Brown EM, Takase H, Wada A, Suzuki K, Kobayashi A, Sugimoto T
- Journal Title
  
  Nephron Clin Pract. 115
  
  Pages: 51-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Bone metabolism after cinacalcet administration in patients with secondary hyperparathyroidism.2010
- Author(s)
  Yano S, Suzuki K, Sumi M, Tokumoto A, Shigeno K, Himeno Y, Sugimoto T
- Journal Title
  
  J Bone Miner Metab. 28
  
  Pages: 49-54
- NAID
  10027206582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] 私の処方維持血液透析中の二次性副甲状腺機能亢進症に対する内科的治療2009
- Author(s)
  矢野彰三, 杉本利嗣
- Journal Title
  
  Modern Physician 29(4)
  
  Pages: 534-535
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Parathyroid Hormone Upregulates BMP-2 mRNA Expression Through Mevalonate Kinase and Rho Kinase Inhibition in Osteoblastic MC3T3-E1 Cells.2009
- Author(s)
  Takase H, Yano S, Yamaguchi T, Kanazawa I, Hayashi K, Yamamoto M, Yamauchi M, Sugimoto T
- Journal Title
  
  Horm Metab Res. 41
  
  Pages: 861-865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus.2009
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T
- Journal Title
  
  J Clin Endocrinol Metab 94
  
  Pages: 45-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] 生体におけるリンの分布と生理的意義:存在様式,分布,生理機能2009
- Author(s)
  矢野彰三, 杉本利嗣
- Journal Title
  
  CLINICAL CALCIUM Vol.19(6)
  
  Pages: 771-776
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fracturesin type 2 diabetes mellitus.2009
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T
- Journal Title
  
  Eur J Endocrinol 160
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Serum DHEA-S level is associated with the presence of atherosc lerosis in postmenopausal women with type 2 diabetes mellitus.2008
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T
- Journal Title
  
  Endocr J 55
  
  Pages: 667-675
- NAID
  10022609033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men.2008
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T
- Journal Title
  
  Calcif Tissue Int 83
  
  Pages: 324-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression2008
- Author(s)
  Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T
- Journal Title
  
  Biochem Biophys Res Commun 375
  
  Pages: 414-419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590974
[Journal Article] The combination of high glucose and advanced glycation end-products (AGEs) unhibit the mineralization of osteoblastic MC3T3-E1 cells through glucose-induced increase in the receptor for AGEs2007
- Author(s)
  Ogawa, N., Yamaguchi, N., Yano, S., Yamauchi, M., Yamamoto, M., Sugimoto, T
- Journal Title
  
  Horm Metab Res 39
  
  Pages: 871-875
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Journal Article] Smad3 differently affects osteoblast differentiation in amanner dependent upon its differentiation stage2006
- Author(s)
  Kaji, H., Naito, J., Sowa, H., Sugimoto, T., Chihara, K
- Journal Title
  
  Horm Metab Res
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Journal Article] Parathyroid hormone increases b-catenin levels through smad3 in mouse osteoblastic cells in osteoblasts2006
- Author(s)
  Tobimatsu, T., Kaji, H., Sowa, H., Naito, J., Hendy, GN.,Sugimoto, T.,Chihara, K
- Journal Title
  
  Endocrinology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Journal Article] Statins modulate the levels of osteoprotegerin/receptor activator of NfkB ligand mRNA in mouse bone cell cultures.2005
- Author(s)
  Kaji H, Kanatani M, Sugimoto T, Chihara K.
- Journal Title
  
  Horm Metab Res 37-10
  
  Pages: 589-592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Journal Article] Low-dose parathyroid hormone and estrogen reverse alkaline phosphatase activity suppressed by dexamethasone in mouse osteoblastic cells.2005
- Author(s)
  Iu MF, Kaji H, Sowa H, Sugimoto T, Chihara K.
- Journal Title
  
  J Bone Miner Metab 23-6
  
  Pages: 450-455
- NAID
  10017133652
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Journal Article] Involvement of calcium-sensing receptor (CaR) in osteoblastic differentiation of mouse MC3T3-E1 cells.2005
- Author(s)
  Yamauchi M, Yamaguchi T, Kaji H, Sugimoto T, Chihara K.
- Journal Title
  
  Am J Physiol Endocrinol Metab 88
  
  Pages: 608-616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Journal Article] Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD.2005
- Author(s)
  Naito J, Kaji H, Sowa H, Hendy GN, Canaff L, Sugimoto T, Chihara K.
- Journal Title
  
  J Biol Chem 280-6
  
  Pages: 4785-4791
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Journal Article] The threshold of bone mineral density for vertebral fractures in patients with primary hyperparathyroidism.2005
- Author(s)
  Kaji H, Yamauchi M, Chihara K, Sugimoto T.
- Journal Title
  
  Eur J Endocrinol 153-3
  
  Pages: 373-378
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Journal Article] Dexamethasone suppresses Smad3 pathway in mouse osteoblastic cells.2005
- Author(s)
  Iu MF, Kaji H, Sowa H, Naito J, Sugimoto T, Chihara K.
- Journal Title
  
  J Endocrinol 185
  
  Pages: 131-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Journal Article] Menin is required for BMP-2- and TGFβ-regulated osteoblastic differentiation through interaction with smads and Runx2.2004
- Author(s)
  Sowa H, Kaji H, Canaff L, Hendy GN, Komori T, Miyazono K, Sugimoto T, Chihara K.
- Journal Title
  
  Biol Chem 279-39
  
  Pages: 40267-40275
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Journal Article] Parathyroid hormone increases β-catenin levels through smad3 in mouse osteoblastic cells.
- Author(s)
  Tobimatsu T, Kaji H, Sowa H, Naito J, Hendy GN, Sugimoto T, Chihara K.
- Journal Title
  
  Endocrinology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590906
[Presentation] Insulin-like growth factor-Iは終末糖化産物AGEsによるアポトーシス促進、筋芽細胞分化抑制を改善する2019
- Author(s)
  足立奈緒子、金沢一平、田中賢一郎、竹野歩、野津雅和、田中小百合、杉本利嗣
- Organizer
  第62回日本糖尿病学会年次集会
- Data Source
  KAKENHI-PROJECT-16K09240
[Presentation] Insulin-like growth factor-I protects against the detrimental effects of advanced glycation end products and high glucose in myoblastic C2C12 cells2019
- Author(s)
  Ippei Kanazawa, Naoko Adachi, Ken-ichiro Tanaka, Ayumu Takeno, Masakazu Notsu, Sayuri Tanaka, Toshitsugu Sugimoto
- Organizer
  American Diabetes Association 79th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09240
[Presentation] 血中DPP-4濃度高値は多発椎体骨折リスクと関連する2015
- Author(s)
  野津雅和、金沢一平、田中小百合、杉本利嗣
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市海峡メッセ下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460899
[Presentation] 2型糖尿病における血清DPP-4濃度とCT診断による内臓脂肪型肥満との関連性の検討2015
- Author(s)
  田中小百合、金沢一平、野津雅和、杉本利嗣
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市海峡メッセ下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460899
[Presentation] Visceral fat obesity and metabolic syndrome increase serum DPP-4 levels in type 2 diabetes mellitus2015
- Author(s)
  Sayuri Tanaka, Ippei Kanazawa, Masakazu Notsu, Toshitsugu Sugimoto
- Organizer
  51th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Sweden, Stockholm
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460899
[Presentation] Increased low-density lipoprotein cholesterol level is associated with non-vertebral fractures in postmenopausal women2014
- Author(s)
  Yamauchi M、Yamaguchi T、Nawata K、Takaoka S、Sugimoto T
- Organizer
  World Congress on Osteoporosis - International Osteoporosis Foundation - The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis
- Place of Presentation
  Seville
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] Increased low-density lipoprotein cholesterol level is associated with non-vertebral fractures in postmenopausal women2014
- Author(s)
  Mika Yamauchi, Toru Yamaguch, Kiyoko Nawata, Ken-ichiro Tanaka, Shin Takaoka, Toshitsugu Sugimoto
- Organizer
  World Congress on Osteoporosis - International Osteoporosis Foundation - The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis.
- Place of Presentation
  Seville
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] 高LDLコレステロール血症の非椎体骨脆弱性に及ぼす影響閉経後女性における検討2012
- Author(s)
  山内美香、山口徹、名和田清子、高岡伸、杉本利嗣
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] Functional hypoparathyroidism is a risk factor for bone fragility of postmenopausal women with vitamin D insufficiency2012
- Author(s)
  Yamauchi M、Nawata K、Kaji H、Takaoka S、Yamaguchi T、Sugimoto T
- Organizer
  15th International and 14th European Congress of Endocrinology
- Place of Presentation
  Florence
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] 閉経後女性における運動機能検査と既存椎体骨折の関連についての検討2012
- Author(s)
  名和田清子、山内美香、田中賢一郎、高岡伸、杉本利嗣
- Organizer
  第14回日本骨粗鬆症学会学術集会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] 骨・カルシウム代謝異常とPTH2012
- Author(s)
  杉本　利嗣
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Invited
- Data Source
  KAKENHI-PROJECT-22590656
[Presentation] 高LDLコレステロール血症の非椎体骨脆弱性に及ぼす影響　閉経後女性における検討2012
- Author(s)
  山内美香, 山口徹, 名和田清子, 高岡伸, 杉本利嗣
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] 閉経後女性における運動機能検査と既存椎体骨折の関連についての検討2012
- Author(s)
  名和田清子, 山内美香, 田中賢一郎, 高岡伸, 杉本利嗣
- Organizer
  第14回日本骨粗鬆症学会学術集会
- Place of Presentation
  朱鷺メッセ（新潟市）
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] 骨粗鬆症治療の進歩2012
- Author(s)
  杉本利嗣
- Organizer
  第109回日本内科学会総会・講演会
- Place of Presentation
  京都・みやこメッセ
- Year and Date
  2012-04-13
- Data Source
  KAKENHI-PROJECT-22590656
[Presentation] 骨・カルシウム代謝異常とPTH2012
- Author(s)
  杉本利嗣
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋・名古屋国際会議場
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-22590656
[Presentation] Relationship between motor function tests and existing vertebral fractures in postmenopausal women2012
- Author(s)
  Nawata K, Yamauchi M, Tanaka K, Takaoka S, Sugimoto T
- Organizer
  International Osteoporosis Foundation Regionals - 3rd Asia-Pacific Osteoporosis Meeting
- Place of Presentation
  Kuala Lumpur
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] Relationship between motor function tests and existing vertebral fractures in postmenopausal women2012
- Author(s)
  Kiyoko Nawata, Mika Yamauchi, Ken Tanaka, Shin Takaoka, Toshitsugu Sugimoto
- Organizer
  International Osteoporosis Foundation Regionals - 3rd Asia-Pacific Osteoporosis Meeting
- Place of Presentation
  Kuala Lumpur, Malaysia
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] Functional hypoparathyroidism is a risk factor for bone fragility of postmenopausal women with vitamin D insufficiency2012
- Author(s)
  Yamauchi M, Nawata K, Kaji H, Takaoka S, Yamaguchi T, Sugimoto T.
- Organizer
  15th International and 14th European Congress of Endocrinology
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] 骨粗鬆症新規治療薬:テリパラチド2012
- Author(s)
  杉本利嗣
- Organizer
  第30回日本骨代謝学会
- Place of Presentation
  東京・京王プラザホテル
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-22590656
[Presentation] 新規骨粗鬆症治療薬:PTH2011
- Author(s)
  杉本利嗣
- Organizer
  第29回日本骨代謝学会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-22590656
[Presentation] 閉経後女性における高LDL血症の骨脆弱性に及ぼす影響2011
- Author(s)
  山内美香, 山口徹, 名和田清子, 高岡伸, 杉本利嗣
- Organizer
  第１３回日本骨粗鬆症学会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] 新規骨粗鬆症治療薬 PTH2011
- Author(s)
  杉本利嗣
- Organizer
  第29回日本骨代謝学会学術集
- Place of Presentation
  大阪・大阪国際会議場
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-22590656
[Presentation] 閉経後女性における高LDL血症の骨脆弱性に及ぼす影響2011
- Author(s)
  山内美香,山口徹,名和田清子,高岡伸,杉本利嗣
- Organizer
  第13回日本骨粗鬆症学会
- Place of Presentation
  神戸
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-23590882
[Presentation] Weight gain is associated with a decrease in eGFR in middle-aged dwelling people.2010
- Author(s)
  Yano S, Nabika T, Sugimoto T
- Organizer
  14^<th> International Congress of Endocrinology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] Assessment of bone tissue composition in patients undergoing dialysis therapy using Raman spectrometry.2010
- Author(s)
  Yano S, Iwasaki Y, Tokumoto A, Yamato H, Yamaguchi T, Sugimoto T
- Organizer
  The 32^<th> American Society for Bone and Mineral Research
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] 透析女性に対するラロキシフェンの効果～3年間の縦断検討～2010
- Author(s)
  矢野彰三, 角昌晃, 名和田清子, 景山明美, 姫野安敏, 杉本利嗣
- Organizer
  第55回日本透析医学会学術集会・総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] 骨形成促進剤としてのPTHの臨床応用への展開2010
- Author(s)
  杉本利嗣
- Organizer
  日本骨代謝学会
- Place of Presentation
  東京
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-22590656
[Presentation] 骨形成促進剤としてのPTHの臨床応用への展開2010
- Author(s)
  杉本利嗣
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  東京・京王プラザホテル
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-22590656
[Presentation] Weight gain is associated with a decrease in eGFR in middle-aged Japanese ; a 5-year follow-up study.2010
- Author(s)
  Yano S, Nabika T, Sugimoto T
- Organizer
  14^<th> International Society of Nephrology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] 副甲状腺ホルモンは骨芽細胞においてメバロン酸-Rhoキナーゼ経路を介してBMP-2mRNA発現を亢進する2009
- Author(s)
  矢野彰三, 山口徹, 高瀬裕史, 金沢一平, 林公美, 山内美香, 山本昌弘, 杉本利嗣
- Organizer
  第27回日本骨代謝学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] 一般住民における腎機能低下に対する肥満の関与2009
- Author(s)
  矢野彰三, 並河徹, 杉本利嗣
- Organizer
  第52回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] シナカルセトの血清Ca低下作用:骨吸収・骨形成のアンカップリングの関与2009
- Author(s)
  矢野彰三, 鈴木恵子, 角昌晃, 滋野和志, 姫野安敏, 徳本明秀, 公受伸之, 杉本利嗣
- Organizer
  第54回日本透析医学会学術集会・総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] Parathyroid Hormone Upregulates BMP-2 mRNA Expression Through Mevalonate Kinase and Rho Kinase Inhibition in Osteoblastic MC3T3-E1 Cells.2009
- Author(s)
  Takase H, Yano S, Yamaguchi T, Kanazawa I, Hayashi K, Yamamoto M, Yamauchi M, Sugimoto T
- Organizer
  The 31^<th> American Society for Bone and Mineral Research
- Place of Presentation
  Denvar, USA
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] Acute change in serum ionized calcium directly affects bone formation independent of PTH action during hemodialysis.2008
- Author(s)
  Yano S, Yamaguchi T, Suzuki K, Sumi M, Himeno Y, Sugimoto T
- Organizer
  The 30^<th> American Society for Bone and Mineral Research
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] 透析患者における副甲状腺機能定量化の試み2008
- Author(s)
  高瀬裕史, 矢野彰三, 鈴木恵子, 山口徹, 杉本利嗣
- Organizer
  第53回日本透析医学会学術集会・総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] 尿毒症物質フェニル酢酸は腎不全による低回転骨の原因物質である2008
- Author(s)
  矢野彰三, 山口徹, 金沢一平, 小川典子, 林公美, 山内美香, 杉本利嗣
- Organizer
  第51回日本腎臓学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] 透析患者における副甲状腺機能定量化の試み:島根県の現状2008
- Author(s)
  高瀬裕史, 矢野彰三, 鈴木恵子, 山口徹, 杉本利嗣
- Organizer
  第53回日本透析医学会学術集会・総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590974
[Presentation] Glucocorticoid suppresses the differentiation of osteoblasts by enhancing the expression of BMP antagonists, follistatin and danm and pretreatment with alendronate and PTH abolish this process2007
- Author(s)
  Hayashi, K., Yamaguchi, T., Yano, S., Yamauchi, M., Yamamoito, M., The, Sugimoto, T
- Organizer
  The American Society for Bone Mineral Research
- Place of Presentation
  Hawaii USA
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Presentation] AMP kinase activator (AICAR) and Rho-kinasse inhibitor (hydroxyfasudil) induce the differentiation and mineralization of osteoblastic MC3T3-E1 cells via inhibiting the mavalonate pathway and enhancing BMP-2 expression2007
- Author(s)
  Kanazawa, I., Yamaguchi, T., Yano, S., yamauchi, M., Yamamoto, M., Sugimoto, T
- Organizer
  The American Society for Bone Mineral Research
- Place of Presentation
  Hawaii USA
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Presentation] Adiponectin stimulates the proliferation, differentiation and mineralization of osteoblastic MC3T3-E1 cells via the adiponectin receptor typel and AMMP signaling pathway2006
- Author(s)
  Kanazawa, I., Yamaguchi, T., Yano, S., Yamauchi, M., Yamamoto, M., Sugimoto, T
- Organizer
  3rd International Osteoporosis Foundation Asia-Pacific Regional Conference onn Osteoporosis & 16th Annual Meeting of the Australian and New Zealand Bone and Mineral Society
- Place of Presentation
  Port Douglas, Australia
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Presentation] 骨形成促迫剤の臨床応用への展開2006
- Author(s)
  杉本利嗣
- Organizer
  日本骨形態計測学会
- Place of Presentation
  新潟
- Year and Date
  2006-07-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Presentation] Role of TGF-b-independent smad3 action in FTH-induced Wnt-b-catenin signaling in osteoblastic cells2006
- Author(s)
  Kaji, H., Tobimatsu, T., Inoue, Y., Sowa, H., Naito, J., Canaff, L., Hendy, GN., Sugimoto, T., Chihgara, K
- Organizer
  The American Society for Bone Mineral Research
- Place of Presentation
  Phyradelphia USA
- Year and Date
  2006-09-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591025
[Presentation] 2型糖尿病男性において血中DPP-4濃度高値は多発椎体骨折の危険因子である
- Author(s)
  野津雅和、金沢一平、田中小百合、杉本利嗣
- Organizer
  第16回日本骨粗鬆症学会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2014-10-23 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-25460899

1. CHIHARA Kazuo (00107955)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. YAMAUCHI Mika (40379681)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
3. YAMAGUCHI Toru (00239899)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. YANO Shozo (80403450)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
5. KANAZAWA Ippei (50452553)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. KAJI Hirohi (90346255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUJITA Takuo (30009964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. BABA Hisamitsu (70189728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUKASE Masaski (80116243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 今井康雄 (70160033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 筒泉正春 (40188595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉本祥生 (50030862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SUGIMOTO Toshitsugu 杉本 利嗣

Research Projects

Research Products

Co-Researchers

Regulation of muscle metabolism by bonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulation of bone metabolism by digestive tract: A study on the mechanism of incretin-induced bone formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Examination of relationships between serum levels of LDL cholesterol and bone metabolism-related indices as well as bone fracture

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of bone formation signal aimed at the development of medical treatment of osteoporosis induced by deterioration of bone formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

To clarify the mechanism of chronic kidney disease progression by uremic toxins and its application for the treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for the elucidation of bone formation signals applied to the development of bone-forming agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for the mechanisms of anabokic action of bone-forming agents on bone for the development of treatment of osteoporosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of the signals of osteoblast differentiation and mineralization including menin and Smad

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for the mechanisms of anabolic action of parathyroid hormone(PTH) on bone and interaction between PTH and estrogen in osteoblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨代謝・骨粗鬆症治療における骨芽細胞カルシウム感知受容体とその作動薬の役割の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for the role of calcium-sensing receptor in parathyroid gland and bonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for the mechanisms of anabolic action of parathyroid hormone (PTH) and interaction between PTH and estrogenPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for role of bone morphogenetic protein in the differentiation and activation of osteoclast and osteoblastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

SUGIMOTO Toshitsugu 杉本利嗣

[Book] ファーマナビゲーター　SERM編2013

[Book] 先制医療日本の未来を拓く医療：治療医学から先制医療へ骨粗鬆症2012

[Book] 先制医療日本の未来を拓く医療:治療医学から先制医療へ:骨粗鬆症2012

[Book] 内科学原発性、二次性副甲状腺機能圧迫症2007

[Book] ホルモンの事典副甲状腺ホルモン2004