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MAEZAKI Naoyoshi  前崎 直容

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前崎 直容  マエザキ ナオヨシ

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Researcher Number 00229296
Other IDs
Affiliation (Current) 2025: 大阪大谷大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2009 – 2011: Otani Womens University, 薬学部, 教授
2006 – 2007: 大阪大谷大学, 薬学部, 教授
2001 – 2005: 大阪大学, 薬学研究科, 助教授
2004: 大阪大学, 薬学研究所, 助教授
1999: Graduate School of Pharmaceutical Sciences, Osaka University Associate Professor, 薬学研究科, 助教授
1998: 大阪大学, 薬学研究科, 助手
1993 – 1996: 大阪大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Chemical pharmacy / Chemical pharmacy / Science and Engineering / Drug development chemistry / 医薬分子機能学
Except Principal Investigator
Chemical pharmacy / 医薬分子機能学 / Bioorganic chemistry / Chemical pharmacy
Keywords
Principal Investigator
不斉非対称化 / 不斉合成 / 有機化学 / キラルスルホキシド / 不斉開裂反応 / Annonaceous Acetogenin / 抗腫瘍活性天然物 / バンレイシ科植物 / 系統的合成 / 立体分岐型合成法 … More / 反復合成法 / 不斉アルキニル化 / 抗腫瘍性天然物 / アノナセオウスアセトゲニン / 生理活性 / 癌 / アセタール / プロキラルジオール / organic chemistry / biological activity / cancer / Anonaceae plant / systematic synthesis / stereodivergent synthesis / reiterative process / asymmetric alkynylation / antitumor natural product / asymmetric synthesis / Annonaceous Plant / Systematic Synthesis / Stereodivergent Synthesis / Reiterative Synthesis / Asymmetric Alkynylation / Antitumor Natural Product / Asymmetric Synthesis / [2,3]-Wittig転位反応 / [2, 3]-Wittig転位反応 / リグナン / 抗酸化剤 / プロテインキナーゼ阻害作用 / clavilactone D / NBD-solamin / アセトゲニン / COMPARE分析 / ヒトがん細胞パネル / longimicin D / murisolin / アロサミゾリン / 擬似糖 / ポリオール / シクリトール / アロザミゾリン / クエルシトール / C2対称ビススルホキシド / 不斉合成素子 / malyngolide / 抗菌物質 / ジヒドロピラン / ビシクロアセタール / 求核的不斉開裂反応 / C2対称ケトン / β脱離反応 / 1,3ーメンジオール / 1,2ーメンジオール / beta-脱離反応 / メソジオール / sigma-対称ジオール … More
Except Principal Investigator
ケチルラジカル / ヨウ化サマリウム / histrionicotoxin / perhydrohistrionicotoxin / ビニルスルホキシド / パラジウム触媒 / π-Allyl Palladium / Amino Allenes / Diethylzinc / Palladium Catalyst / Sulfinyl Anion / Ketyl Radical / Spirocyclization / Samarium Iodide / アレン / HMPA / SmI2 / π-アリルパラジウム錯体 / アミノアレン / ジエチル亜鉛 / スルフィニルアニオン / スピロ閉環反応 / ipso-Substitution reaction / Radical reaction / Ketyl radical / Samarium iodide / Benzyl cation / Arene chromium complex / Synthesis / Macrocarpal / 炭素炭素形成反応 / 脱メチル化 / 立体化学制御 / ペンジルカチオン / アレンクロミウム錯体 / マクロカルパアール / 置換基効果 / メトキシ基 / 炭素炭素結合形成反応 / キレーション制御 / イプソ置換反応 / ラジカル反応 / ベンジルカチオン / 6置換アレンクロム錯体 / 合成 / マクロカルパール / intramolecular allylation / neurotransmission inhibitor / asymmetric synthesis / vinylic sulfoxide / Pummerer-type reaction / (+)-malyngolide / カルボニル-エン反応 / perhydrohistroinicotoxin / 分子内アリル化反応 / 神経伝達阻害作用 / 不斉合成 / 付加型Pummerer反応 / スルフェン酸亜鉛 / タンデム反応 / シクロプロパン / パラジウムカルベン Less
  • Research Projects

    (14 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (7 People)
  •  Development of antioxidant with lignan skeletonPrincipal Investigator

    • Principal Investigator
      MAEZAKI Naoyoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka Ohtani University
  •  HIF-1α阻害剤マナサンチンBのバイオプローブ化Principal Investigator

    • Principal Investigator
      田中 徹明, 前崎 直容
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Osaka University
      Osaka Ohtani University
  •  Synthetic Study of HIF-1α Inhibitor, Manassantin BPrincipal Investigator

    • Principal Investigator
      MAEZAKI Naoyoshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Otani Womens University
  •  抗腫瘍活性天然物の合成と分子生物学研究用ツールの開発Principal Investigator

    • Principal Investigator
      前崎 直容
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Osaka University
  •  Development of Systematic Synthesis of Antitumor Annonaceous Acetogenins and Evaluation of Biological ActivityPrincipal Investigator

    • Principal Investigator
      MAEZAKI Naoyoshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University
  •  パラジウム触媒を用いた新規反応活性種の創出と合成反応への利用

    • Principal Investigator
      TANAKA Tatsuaki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University
  •  Development of Efficient Synthetic Method of Antitamor Annonaceous Acetogenins and Investigation of Highly Potent DerivativesPrincipal Investigator

    • Principal Investigator
      MAEZAKI Naoyoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University
  •  Synthesis of Biologically Active Compounds Using Potential Utility of Transition Metals

    • Principal Investigator
      TANAKA Tetsuaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University
  •  不斉非対称化による生理活性疑似糖の不斉合成研究Principal Investigator

    • Principal Investigator
      前崎 直容
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Osaka University
  •  Synthetic Studies toward Surveying Biologically Active Compounds from Solubility

    • Principal Investigator
      TANAKA Tetsuaki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Osaka University
  •  硫黄を不斉源とするAnchor型オキソニウム中間体の不斉伝搬作用Principal Investigator

    • Principal Investigator
      前崎 直容
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University
  •  C2対称ケトンを用いる不斉非対称化法の開発Principal Investigator

    • Principal Investigator
      前崎 直容
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University
  •  Study for Asymmetric Syntheses of Alkaloids with Nurotransmission Inhibitory Effects

    • Principal Investigator
      IWATA Chuzo
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Osaka University
  •  メソ及びプロキラルジオールの不斉認識試薬の開発研究Principal Investigator

    • Principal Investigator
      前崎 直容
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University

All 2012 2011 2010 2009 2007 2006 2005 2004

All Journal Article Presentation

  • [Journal Article] Bis(oxazoline)-ligand-mediated asymmetric[2, 3]-Wittig rearrangement of benzyl ethers : Reaction mechanism based on the hydrogen/deuterium exchange effect2012

    • Author(s)
      M. Kitamura, Y. Hirokawa, Y. Yoshioka, and N. Maezaki
    • Journal Title

      Tetrahedron

      Volume: 68(22) Issue: 22 Pages: 4280-4285

    • DOI

      10.1016/j.tet.2012.03.059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Journal Article] Total Synthesis of(+)-Eupomatilone 2 via Asymmetric[2, 3]-Wittig Rearrangement of Highly Oxygenated Biphenylmethyl Ethers2011

    • Author(s)
      Y. Hirokawa, M. Kitamura, C. Kato, Y. Kurata, and N. Maezaki
    • Journal Title

      Tetrahedron Lett

      Volume: 52(5) Issue: 5 Pages: 581-583

    • DOI

      10.1016/j.tetlet.2010.11.126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Journal Article] Asymmetric [2, 3]-Wittig Rearrangement of Oxygenated Allyl Benzyl Ethers in the Presence of a Chiral di-tBu-bis(oxazoline) Ligand : A Novel Synthetic Approach to THF Lignans2009

    • Author(s)
      M. Kitamura, Y. Hirokawa, and N. Maezaki
    • Journal Title

      Chem. Eur. J

      Volume: 15(38) Issue: 38 Pages: 9911-9917

    • DOI

      10.1002/chem.200901212

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Journal Article] A Stereocontrolled Construction of rel -(7S, 8S, 7'R, 8'S)-7,7'-Epoxylignan Skeleton2007

    • Author(s)
      Naoyoshi Maezaki, Tetsuaki Tanaka, et al.
    • Journal Title

      Heterocycles 71

      Pages: 2669-2680

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18032048
  • [Journal Article] Synthesis of Fluorescent Solamin for Visualization of Cell Distribution2007

    • Author(s)
      Naoyoshi Maezaki, Naoto Kojima, Tetsuaki Tanaka, et al.
    • Journal Title

      Heterocycles 73

      Pages: 159-164

    • NAID

      40015763783

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18032048
  • [Journal Article] Systematic Synthesis of Diastereomeric THE Ring Cores and Total Synthesis of Anti-Tumor Annonaceous Acetogenins2006

    • Author(s)
      MAEZAKI, Naoyoshi
    • Journal Title

      Synlett -・7

      Pages: 993-1003

    • Data Source
      KAKENHI-PROJECT-18590097
  • [Journal Article] First Total Synthesis of Longimicin D2006

    • Author(s)
      Hiroaki Tominaga, Naoyshi Maezaki et al.
    • Journal Title

      Eur. J. Org. Chem 6号

      Pages: 1422-1429

    • Data Source
      KAKENHI-PROJECT-18032048
  • [Journal Article] Systematic Syhthesis of Diastereomeric THF-ring Cores and Total Synthesis of Antitumor Annoriaceous Acetogenins2006

    • Author(s)
      Naoyoshi Maezaki
    • Journal Title

      Synlett (in press)

    • Data Source
      KAKENHI-PROJECT-17035052
  • [Journal Article] Stereodivergent Synthesis of 1,4-Bifunctional Compounds by Regio- and Diastereoselective Pd-Catalyzed Allylic Substitution Reaction2006

    • Author(s)
      MAEZAKI, Naoyoshi
    • Journal Title

      Tetrahedron 62・44

      Pages: 10361-10378

    • Data Source
      KAKENHI-PROJECT-18590097
  • [Journal Article] Systematic Synthesis of Diastereomeric THF-ring Cores and Total Synthesis of Antitumor Annonaceous Acetogenins2006

    • Author(s)
      Naoyoshi Maezaki
    • Journal Title

      Synlett (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590006
  • [Journal Article] Systematic Synthesis of Diastereomeric THE-ring Cores and Total Synthesis of Antitumor Annonaceous Acetogenins2006

    • Author(s)
      Naoyoshi Maezaki et al.
    • Journal Title

      Synlett 7号

      Pages: 993-1003

    • Data Source
      KAKENHI-PROJECT-18032048
  • [Journal Article] Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity2005

    • Author(s)
      Naoyoshi Maezaki
    • Journal Title

      Chemistry-A European Journal 11・21

      Pages: 6237-6245

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590006
  • [Journal Article] Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity2005

    • Author(s)
      Naoyoshi Maezaki
    • Journal Title

      Chemistry-A European Journal 11・21

      Pages: 6237-6245

    • Data Source
      KAKENHI-PROJECT-17035052
  • [Journal Article] Asymmetric Intramolecular Michael Addition of α-Sulfinyl Vinylic Carbanion to Enoate2004

    • Author(s)
      Naoyoshi Maezaki
    • Journal Title

      The Journal of Organic Chemistry 69・19

      Pages: 6335-6340

    • Data Source
      KAKENHI-PROJECT-15659003
  • [Journal Article] First Total Synthesis of Murisolin2004

    • Author(s)
      Naoyoshi Maezaki
    • Journal Title

      Chemical Communications 4

      Pages: 406-407

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590006
  • [Journal Article] Geometrically Selective Synthesis of Sulfur-containing Heterocycles Intramolecular Pd-Catalyzed Sulfinylzincation2004

    • Author(s)
      Naoyoshi Maezaki
    • Journal Title

      Heterocycles 62・1

      Pages: 263-277

    • NAID

      80016336230

    • Data Source
      KAKENHI-PROJECT-15659003
  • [Journal Article] First total synthesis of murisolin2004

    • Author(s)
      Naoyoshi Maezaki
    • Journal Title

      Chemical Communications -・4

      Pages: 406-407

    • Data Source
      KAKENHI-PROJECT-16590006
  • [Presentation] 不斉[2, 3]-Wittig転位反応を鍵反応としたeupomatilone類の不斉合成研究2012

    • Author(s)
      水林誠, 北村麻理愛, 広川美視, 加藤千晴, 倉田祐希, 前崎直容
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] A Synthesis of Eupomatilones Using Enantioselective [2, 3]-Wittig Rearrangement2011

    • Author(s)
      M. Kitamura, Y. Hirokawa, C. Kato, Y. Kurata, M. Mizubayashi, and N. Maezaki
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium Frontier of Medicinal Science
    • Place of Presentation
      東京
    • Year and Date
      2011-11-30
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] Eupomatilone類縁体の合成研究2011

    • Author(s)
      北村麻理愛, 広川美視, 前崎直容
    • Organizer
      第41回複素環化学討論会
    • Place of Presentation
      熊本
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] 光学活性ビスオキサゾリン配位子を用いたベンジルエーテル類の不斉[2, 3]-Wittig転位反応の反応機構の考察2011

    • Author(s)
      北村麻理愛, 吉岡勇輝, 広川美視, 前崎直容
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2011-11-08
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] 2, 5-ジアリールTHFリグナンの各種立体異性体の合成研究2011

    • Author(s)
      守行美穂, 北村麻理愛, 広川美視, 前崎直容
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] Eupomatilone 2及びその類縁体の不斉合成2011

    • Author(s)
      加藤千晴, 倉田祐希, 広川美視, 北村麻理愛, 前崎直容
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] Eupomatilone 2の合成2010

    • Author(s)
      前崎直容, 加藤千晴, 倉田祐樹, 北村麻理愛, 広川美視
    • Organizer
      第40回複素環化学討論会
    • Place of Presentation
      仙台
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] 不斉[2, 3]-Wittig転位反応を鍵反応としたTHF-リグナン類の合成法の研究2010

    • Author(s)
      広川美視, 北村麻理愛, 前崎直容
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] 不斉[2,3]-Wittig転位反応を鍵反応としたTHF-リグナン類の合成法の研究2010

    • Author(s)
      広川美視, 北村麻理愛, 前崎直容
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      桃太郎アリーナ(岡山)
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] Eupomatilone 2の合成2010

    • Author(s)
      前崎直容
    • Organizer
      第40回複素環化学討論会
    • Place of Presentation
      仙台市民会館(仙台)
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] Eupomatilone 2の不斉合成研究2010

    • Author(s)
      北村麻理愛, 加藤千晴, 倉田祐樹, 広川美視, 前崎直容
    • Organizer
      第60回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-30
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] ベンジルエーテル類の不斉[2,3]-Wittig転位反応-反応機構の考察-2009

    • Author(s)
      前崎直容, 北村麻理愛, 広川美視
    • Organizer
      第22回複素環化学討論会
    • Place of Presentation
      さわやかちば県民プラザ(千葉)
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] 不斉[2,3]-Wittig転位反応を鍵反応としたリグナン類の系統的合成研究2009

    • Author(s)
      北村麻理愛, 広川美視, 前崎直容
    • Organizer
      第59回日本薬学会近畿支部大会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] 不斉[2, 3]-Wittig転位反応を鍵反応としたリグナン類の系統的合成研究2009

    • Author(s)
      北村麻理愛, 広川美視, 前崎直容
    • Organizer
      第59回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] Application Of Enantioselective [2, 3]-Wittig Rearrangement To Construction Of Lignan Skeleton2009

    • Author(s)
      北村麻理愛, 広川美視, 前崎直容
    • Organizer
      第22回国際複素環化学会議
    • Place of Presentation
      セント・ジョーンズ,カナダ
    • Year and Date
      2009-08-05
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] ベンジルエーテル類の不斉[2, 3]-Wittig転位反応-反応機構の考察-2009

    • Author(s)
      前崎直容, 北村麻理愛, 広川美視
    • Organizer
      第39回複素環化学討論会
    • Place of Presentation
      千葉
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-21590032
  • [Presentation] rel-(7S, 8S, 7'R, 8'S)-7,7'-エポキシリグナン骨格の立体選採的構築法の開発2007

    • Author(s)
      北村麻理愛, 前崎直容, 田中徹明, et al.
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野
    • Year and Date
      2007-10-18
    • Data Source
      KAKENHI-PROJECT-18032048
  • [Presentation] SYNTHESIS OF FLUORESCENT SOLAMIN FOR VISUALIZATION OF CELL DISTRIBUTION2007

    • Author(s)
      Naoyoshi Maezaki, Naoto Kojima, Tetsuaki Tanaka, et al.
    • Organizer
      21st International Congress for Heterocyclic Chemistry
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2007-07-16
    • Data Source
      KAKENHI-PROJECT-18032048
  • 1.  TANAKA Tatsuaki (40116059)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 4 results
  • 2.  OHNO Hiroaki (30322192)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  HIROKAWA Yoshimi (40454582)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 4.  KITAMURA Maria (00434811)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 5.  IWATA Chuzo (60028842)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  好光 健彦 (30301576)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  小島 直人 (90420413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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