MAEZAKI Naoyoshi 前崎直容

Researcher Number	00229296
Other IDs
Affiliation (Current)	2022: 大阪大谷大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2009 – 2011: Otani Womens University, 薬学部, 教授 2006 – 2007: 大阪大谷大学, 薬学部, 教授 2001 – 2005: 大阪大学, 薬学研究科, 助教授 2004: 大阪大学, 薬学研究所, 助教授 1999: Graduate School of Pharmaceutical Sciences, Osaka University Associate Professor, 薬学研究科, 助教授 1998: 大阪大学, 薬学研究科, 助手 1993 – 1996: 大阪大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy / Science and Engineering / Chemical pharmacy / 医薬分子機能学 / Drug development chemistry Except Principal Investigator Chemical pharmacy / Bioorganic chemistry / 医薬分子機能学 / Chemical pharmacy
Keywords	Principal Investigator 不斉非対称化 / 不斉開裂反応 / キラルスルホキシド / 有機化学 / 不斉合成 / プロキラルジオール / アセタール / 癌 / 生理活性 / アノナセオウスアセトゲニン … More / 抗腫瘍性天然物 / 不斉アルキニル化 / 反復合成法 / 立体分岐型合成法 / 系統的合成 / バンレイシ科植物 / 抗腫瘍活性天然物 / Annonaceous Acetogenin / sigma-対称ジオール / メソジオール / beta-脱離反応 / 1,2ーメンジオール / 1,3ーメンジオール / β脱離反応 / C2対称ケトン / 求核的不斉開裂反応 / ビシクロアセタール / ジヒドロピラン / 抗菌物質 / malyngolide / 不斉合成素子 / C2対称ビススルホキシド / クエルシトール / アロザミゾリン / シクリトール / ポリオール / 擬似糖 / アロサミゾリン / murisolin / longimicin D / ヒトがん細胞パネル / COMPARE分析 / アセトゲニン / NBD-solamin / clavilactone D / プロテインキナーゼ阻害作用 / 抗酸化剤 / リグナン / [2, 3]-Wittig転位反応 / [2,3]-Wittig転位反応 / Asymmetric Synthesis / Antitumor Natural Product / Asymmetric Alkynylation / Reiterative Synthesis / Stereodivergent Synthesis / Systematic Synthesis / Annonaceous Plant / asymmetric synthesis / antitumor natural product / asymmetric alkynylation / reiterative process / stereodivergent synthesis / systematic synthesis / Anonaceae plant / cancer / biological activity / organic chemistry … More Except Principal Investigator パラジウム触媒 / ビニルスルホキシド / perhydrohistrionicotoxin / histrionicotoxin / ヨウ化サマリウム / ケチルラジカル / パラジウムカルベン / シクロプロパン / タンデム反応 / スルフェン酸亜鉛 / 付加型Pummerer反応 / 不斉合成 / 神経伝達阻害作用 / 分子内アリル化反応 / perhydrohistroinicotoxin / カルボニル-エン反応 / (+)-malyngolide / Pummerer-type reaction / vinylic sulfoxide / asymmetric synthesis / neurotransmission inhibitor / intramolecular allylation / マクロカルパール / 合成 / 6置換アレンクロム錯体 / ベンジルカチオン / ラジカル反応 / イプソ置換反応 / キレーション制御 / 炭素炭素結合形成反応 / メトキシ基 / 置換基効果 / マクロカルパアール / アレンクロミウム錯体 / ペンジルカチオン / 立体化学制御 / 脱メチル化 / 炭素炭素形成反応 / Macrocarpal / Synthesis / Arene chromium complex / Benzyl cation / Samarium iodide / Ketyl radical / Radical reaction / ipso-Substitution reaction / スピロ閉環反応 / スルフィニルアニオン / ジエチル亜鉛 / アミノアレン / π-アリルパラジウム錯体 / SmI2 / HMPA / アレン / Samarium Iodide / Spirocyclization / Ketyl Radical / Sulfinyl Anion / Palladium Catalyst / Diethylzinc / Amino Allenes / π-Allyl Palladium Less

Development of antioxidant with lignan skeletonPrincipal Investigator
- Principal Investigator
  
  MAEZAKI Naoyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka Ohtani University
HIF-1α阻害剤マナサンチンBのバイオプローブ化Principal Investigator
- Principal Investigator
  
  田中徹明, 前崎直容
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Osaka University
  Osaka Ohtani University
Synthetic Study of HIF-1α Inhibitor, Manassantin BPrincipal Investigator
- Principal Investigator
  
  MAEZAKI Naoyoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Otani Womens University
抗腫瘍活性天然物の合成と分子生物学研究用ツールの開発Principal Investigator
- Principal Investigator
  
  前崎直容
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Osaka University
Development of Systematic Synthesis of Antitumor Annonaceous Acetogenins and Evaluation of Biological ActivityPrincipal Investigator
- Principal Investigator
  
  MAEZAKI Naoyoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
パラジウム触媒を用いた新規反応活性種の創出と合成反応への利用
- Principal Investigator
  
  TANAKA Tatsuaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
Development of Efficient Synthetic Method of Antitamor Annonaceous Acetogenins and Investigation of Highly Potent DerivativesPrincipal Investigator
- Principal Investigator
  
  MAEZAKI Naoyoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
Synthesis of Biologically Active Compounds Using Potential Utility of Transition Metals
- Principal Investigator
  
  TANAKA Tetsuaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
不斉非対称化による生理活性疑似糖の不斉合成研究Principal Investigator
- Principal Investigator
  
  前崎直容
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
Synthetic Studies toward Surveying Biologically Active Compounds from Solubility
- Principal Investigator
  
  TANAKA Tetsuaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
硫黄を不斉源とするAnchor型オキソニウム中間体の不斉伝搬作用Principal Investigator
- Principal Investigator
  
  前崎直容
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
C2対称ケトンを用いる不斉非対称化法の開発Principal Investigator
- Principal Investigator
  
  前崎直容
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
Study for Asymmetric Syntheses of Alkaloids with Nurotransmission Inhibitory Effects
- Principal Investigator
  
  IWATA Chuzo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Osaka University
メソ及びプロキラルジオールの不斉認識試薬の開発研究Principal Investigator
- Principal Investigator
  
  前崎直容
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University

All 2012 2011 2010 2009 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Bis(oxazoline)-ligand-mediated asymmetric[2, 3]-Wittig rearrangement of benzyl ethers : Reaction mechanism based on the hydrogen/deuterium exchange effect2012
- Author(s)
  M. Kitamura, Y. Hirokawa, Y. Yoshioka, and N. Maezaki
- Journal Title
  
  Tetrahedron
  
  Volume: 68(22) Pages: 4280-4285
- DOI
  10.1016/j.tet.2012.03.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590032
[Journal Article] Total Synthesis of(+)-Eupomatilone 2 via Asymmetric[2, 3]-Wittig Rearrangement of Highly Oxygenated Biphenylmethyl Ethers2011
- Author(s)
  Y. Hirokawa, M. Kitamura, C. Kato, Y. Kurata, and N. Maezaki
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 52(5) Pages: 581-583
- DOI
  10.1016/j.tetlet.2010.11.126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590032
[Journal Article] Asymmetric [2, 3]-Wittig Rearrangement of Oxygenated Allyl Benzyl Ethers in the Presence of a Chiral di-tBu-bis(oxazoline) Ligand : A Novel Synthetic Approach to THF Lignans2009
- Author(s)
  M. Kitamura, Y. Hirokawa, and N. Maezaki
- Journal Title
  
  Chem. Eur. J
  
  Volume: 15(38) Pages: 9911-9917
- DOI
  10.1002/chem.200901212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590032
[Journal Article] A Stereocontrolled Construction of rel -(7S, 8S, 7'R, 8'S)-7,7'-Epoxylignan Skeleton2007
- Author(s)
  Naoyoshi Maezaki, Tetsuaki Tanaka, et al.
- Journal Title
  
  Heterocycles 71
  
  Pages: 2669-2680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032048
[Journal Article] Synthesis of Fluorescent Solamin for Visualization of Cell Distribution2007
- Author(s)
  Naoyoshi Maezaki, Naoto Kojima, Tetsuaki Tanaka, et al.
- Journal Title
  
  Heterocycles 73
  
  Pages: 159-164
- NAID
  40015763783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032048
[Journal Article] Systematic Synthesis of Diastereomeric THE Ring Cores and Total Synthesis of Anti-Tumor Annonaceous Acetogenins2006
- Author(s)
  MAEZAKI, Naoyoshi
- Journal Title
  
  Synlett -・7
  
  Pages: 993-1003
- Data Source
  KAKENHI-PROJECT-18590097
[Journal Article] First Total Synthesis of Longimicin D2006
- Author(s)
  Hiroaki Tominaga, Naoyshi Maezaki et al.
- Journal Title
  
  Eur. J. Org. Chem 6号
  
  Pages: 1422-1429
- Data Source
  KAKENHI-PROJECT-18032048
[Journal Article] Systematic Syhthesis of Diastereomeric THF-ring Cores and Total Synthesis of Antitumor Annoriaceous Acetogenins2006
- Author(s)
  Naoyoshi Maezaki
- Journal Title
  
  Synlett (in press)
- Data Source
  KAKENHI-PROJECT-17035052
[Journal Article] Stereodivergent Synthesis of 1,4-Bifunctional Compounds by Regio- and Diastereoselective Pd-Catalyzed Allylic Substitution Reaction2006
- Author(s)
  MAEZAKI, Naoyoshi
- Journal Title
  
  Tetrahedron 62・44
  
  Pages: 10361-10378
- Data Source
  KAKENHI-PROJECT-18590097
[Journal Article] Systematic Synthesis of Diastereomeric THF-ring Cores and Total Synthesis of Antitumor Annonaceous Acetogenins2006
- Author(s)
  Naoyoshi Maezaki
- Journal Title
  
  Synlett (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590006
[Journal Article] Systematic Synthesis of Diastereomeric THE-ring Cores and Total Synthesis of Antitumor Annonaceous Acetogenins2006
- Author(s)
  Naoyoshi Maezaki et al.
- Journal Title
  
  Synlett 7号
  
  Pages: 993-1003
- Data Source
  KAKENHI-PROJECT-18032048
[Journal Article] Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity2005
- Author(s)
  Naoyoshi Maezaki
- Journal Title
  
  Chemistry-A European Journal 11・21
  
  Pages: 6237-6245
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590006
[Journal Article] Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity2005
- Author(s)
  Naoyoshi Maezaki
- Journal Title
  
  Chemistry-A European Journal 11・21
  
  Pages: 6237-6245
- Data Source
  KAKENHI-PROJECT-17035052
[Journal Article] Asymmetric Intramolecular Michael Addition of α-Sulfinyl Vinylic Carbanion to Enoate2004
- Author(s)
  Naoyoshi Maezaki
- Journal Title
  
  The Journal of Organic Chemistry 69・19
  
  Pages: 6335-6340
- Data Source
  KAKENHI-PROJECT-15659003
[Journal Article] First Total Synthesis of Murisolin2004
- Author(s)
  Naoyoshi Maezaki
- Journal Title
  
  Chemical Communications 4
  
  Pages: 406-407
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590006
[Journal Article] Geometrically Selective Synthesis of Sulfur-containing Heterocycles Intramolecular Pd-Catalyzed Sulfinylzincation2004
- Author(s)
  Naoyoshi Maezaki
- Journal Title
  
  Heterocycles 62・1
  
  Pages: 263-277
- NAID
  80016336230
- Data Source
  KAKENHI-PROJECT-15659003
[Journal Article] First total synthesis of murisolin2004
- Author(s)
  Naoyoshi Maezaki
- Journal Title
  
  Chemical Communications -・4
  
  Pages: 406-407
- Data Source
  KAKENHI-PROJECT-16590006
[Presentation] 不斉[2, 3]-Wittig転位反応を鍵反応としたeupomatilone類の不斉合成研究2012
- Author(s)
  水林誠, 北村麻理愛, 広川美視, 加藤千晴, 倉田祐希, 前崎直容
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] A Synthesis of Eupomatilones Using Enantioselective [2, 3]-Wittig Rearrangement2011
- Author(s)
  M. Kitamura, Y. Hirokawa, C. Kato, Y. Kurata, M. Mizubayashi, and N. Maezaki
- Organizer
  8th AFMC International Medicinal Chemistry Symposium Frontier of Medicinal Science
- Place of Presentation
  東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] Eupomatilone類縁体の合成研究2011
- Author(s)
  北村麻理愛, 広川美視, 前崎直容
- Organizer
  第41回複素環化学討論会
- Place of Presentation
  熊本
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] 光学活性ビスオキサゾリン配位子を用いたベンジルエーテル類の不斉[2, 3]-Wittig転位反応の反応機構の考察2011
- Author(s)
  北村麻理愛, 吉岡勇輝, 広川美視, 前崎直容
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] 2, 5-ジアリールTHFリグナンの各種立体異性体の合成研究2011
- Author(s)
  守行美穂, 北村麻理愛, 広川美視, 前崎直容
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] Eupomatilone 2及びその類縁体の不斉合成2011
- Author(s)
  加藤千晴, 倉田祐希, 広川美視, 北村麻理愛, 前崎直容
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] Eupomatilone 2の合成2010
- Author(s)
  前崎直容, 加藤千晴, 倉田祐樹, 北村麻理愛, 広川美視
- Organizer
  第40回複素環化学討論会
- Place of Presentation
  仙台
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] 不斉[2, 3]-Wittig転位反応を鍵反応としたTHF-リグナン類の合成法の研究2010
- Author(s)
  広川美視, 北村麻理愛, 前崎直容
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] 不斉[2,3]-Wittig転位反応を鍵反応としたTHF-リグナン類の合成法の研究2010
- Author(s)
  広川美視, 北村麻理愛, 前崎直容
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ(岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] Eupomatilone 2の合成2010
- Author(s)
  前崎直容
- Organizer
  第40回複素環化学討論会
- Place of Presentation
  仙台市民会館(仙台)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] Eupomatilone 2の不斉合成研究2010
- Author(s)
  北村麻理愛, 加藤千晴, 倉田祐樹, 広川美視, 前崎直容
- Organizer
  第60回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] ベンジルエーテル類の不斉[2,3]-Wittig転位反応-反応機構の考察-2009
- Author(s)
  前崎直容, 北村麻理愛, 広川美視
- Organizer
  第22回複素環化学討論会
- Place of Presentation
  さわやかちば県民プラザ(千葉)
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] 不斉[2,3]-Wittig転位反応を鍵反応としたリグナン類の系統的合成研究2009
- Author(s)
  北村麻理愛, 広川美視, 前崎直容
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  近畿大学(大阪)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] 不斉[2, 3]-Wittig転位反応を鍵反応としたリグナン類の系統的合成研究2009
- Author(s)
  北村麻理愛, 広川美視, 前崎直容
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] Application Of Enantioselective [2, 3]-Wittig Rearrangement To Construction Of Lignan Skeleton2009
- Author(s)
  北村麻理愛, 広川美視, 前崎直容
- Organizer
  第22回国際複素環化学会議
- Place of Presentation
  セント・ジョーンズ,カナダ
- Year and Date
  2009-08-05
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] ベンジルエーテル類の不斉[2, 3]-Wittig転位反応-反応機構の考察-2009
- Author(s)
  前崎直容, 北村麻理愛, 広川美視
- Organizer
  第39回複素環化学討論会
- Place of Presentation
  千葉
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590032
[Presentation] rel-(7S, 8S, 7'R, 8'S)-7,7'-エポキシリグナン骨格の立体選採的構築法の開発2007
- Author(s)
  北村麻理愛, 前崎直容, 田中徹明, et al.
- Organizer
  第37回複素環化学討論会
- Place of Presentation
  長野
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-18032048
[Presentation] SYNTHESIS OF FLUORESCENT SOLAMIN FOR VISUALIZATION OF CELL DISTRIBUTION2007
- Author(s)
  Naoyoshi Maezaki, Naoto Kojima, Tetsuaki Tanaka, et al.
- Organizer
  21st International Congress for Heterocyclic Chemistry
- Place of Presentation
  Sydney, Australia
- Year and Date
  2007-07-16
- Data Source
  KAKENHI-PROJECT-18032048

1. TANAKA Tatsuaki (40116059)

# of Collaborated Projects: 9 results

# of Collaborated Products: 4 results
2. OHNO Hiroaki (30322192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HIROKAWA Yoshimi (40454582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. KITAMURA Maria (00434811)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. IWATA Chuzo (60028842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 好光健彦 (30301576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小島直人 (90420413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

MAEZAKI Naoyoshi 前崎 直容

Research Projects

Research Products

Co-Researchers

Development of antioxidant with lignan skeletonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HIF-1α阻害剤マナサンチンBのバイオプローブ化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic Study of HIF-1α Inhibitor, Manassantin BPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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抗腫瘍活性天然物の合成と分子生物学研究用ツールの開発Principal Investigator

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Development of Systematic Synthesis of Antitumor Annonaceous Acetogenins and Evaluation of Biological ActivityPrincipal Investigator

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パラジウム触媒を用いた新規反応活性種の創出と合成反応への利用

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Development of Efficient Synthetic Method of Antitamor Annonaceous Acetogenins and Investigation of Highly Potent DerivativesPrincipal Investigator

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Synthesis of Biologically Active Compounds Using Potential Utility of Transition Metals

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不斉非対称化による生理活性疑似糖の不斉合成研究Principal Investigator

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Synthetic Studies toward Surveying Biologically Active Compounds from Solubility

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硫黄を不斉源とするAnchor型オキソニウム中間体の不斉伝搬作用Principal Investigator

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C2対称ケトンを用いる不斉非対称化法の開発Principal Investigator

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Study for Asymmetric Syntheses of Alkaloids with Nurotransmission Inhibitory Effects

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MAEZAKI Naoyoshi 前崎直容